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Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou Jan 2006

Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou

Faculty Publications, Biological Sciences

The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation of farnesylated prelamin A leads to these accelerated aging phenotypes is not understood. Here we present evidence that in HGPS and RD fibroblasts, DNA damage checkpoints are persistently activated because of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their …

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Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol Jan 2006

Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol

Faculty Publications, Biological Sciences

Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility …

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Monopsonistic Wage Discrimination And Employment Effect Under Conditions Of Constant Labor Supply Elasticity, Yeung-Nan Shieh Jan 2006

Monopsonistic Wage Discrimination And Employment Effect Under Conditions Of Constant Labor Supply Elasticity, Yeung-Nan Shieh

Faculty Publications

No abstract provided.

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Hydrodynamic Description Of The Adiabatic Piston, Alejandro Garcia, M. M. Mansour Jan 2006

Hydrodynamic Description Of The Adiabatic Piston, Alejandro Garcia, M. M. Mansour

Faculty Publications

A closed macroscopic equation for the motion of the two-dimensional adiabatic piston is derived from standard hydrodynamics. It predicts a damped oscillatory motion of the piston towards a final rest position, which depends on the initial state. In the limit of large piston mass, the solution of this equation is in quantitative agreement with the results obtained from both hard disk molecular dynamics and hydrodynamics. The explicit forms of the basic characteristics of the piston’s dynamics, such as the period of oscillations and the relaxation time, are derived. The limitations of the theory’s validity, in terms of the main system …

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Loss Aware Rate Allocations In H.263 Coded Video Transmissions, Xiao Su, Benjamin Wah Dec 2005

Loss Aware Rate Allocations In H.263 Coded Video Transmissions, Xiao Su, Benjamin Wah

Faculty Publications

For packet video, information loss and bandwidth limitation are two factors that affect video playback quality. Traditional rate allocation approaches have focused on optimizing video quality under bandwidth constraint alone. However, in the best-effort Internet, packets carrying video data are susceptible to losses, which need to be reconstructed at the receiver side. In this paper, we propose loss aware rate allocations in both group-of-block (GOB) level and macroblock level, given that certain packets are lost during transmissions and reconstructed using simple interpolation methods at the receiver side. Experimental results show that our proposed algorithms can produce videos of higher quality …

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Polylogic Minds: Interview With Dr. Soteria (Roula) Svorou, Niko Shido Dec 2005

Polylogic Minds: Interview With Dr. Soteria (Roula) Svorou, Niko Shido

SWITCH

This interview with linguist Dr. Roula Svorou explores how language connects with fields like cognitive science, technology, philosophy, and digital media to help us understand how humans think and perceive the world. She explains how studying language reveals why computers struggle to truly “understand” and how digital media art could become an important tool for visualizing complex linguistic ideas.

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Information Outlook, November 2005, Special Libraries Association Nov 2005

Information Outlook, November 2005, Special Libraries Association

Information Outlook, 2005

Volume 9, Issue 11

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Spartan Daily, October 3, 2005, San Jose State University, School Of Journalism And Mass Communications Oct 2005

Spartan Daily, October 3, 2005, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 125, Issue 21

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Information As A Value Concept, Thomas Weissinger Oct 2005

Information As A Value Concept, Thomas Weissinger

Library Philosophy and Practice (e-journal)

Philosophically, materialists and idealists understand the world differently. In materialist theory information directly represents the natural world, whereas idealism understands it to be the very structure of thought. Some of the problems arising between information theory and the actual practice of librarianship are due to mixing concepts from incompatible theories. The concept of information favored by materialist theories is not interchangeable with the concepts preferred by idealists and critical theorists. Materialism overemphasizes the empirical features of information, while giving short shrift to the possibility that information can be both factual and evaluative. Consequently, this leads to theories of information which …

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Prediction Of Sediment-Bound Nutrient Delivery From Semi-Arid California Watersheds, Emmanuel Gabet, Noah Fierer, Oliver Chadwick Oct 2005

Prediction Of Sediment-Bound Nutrient Delivery From Semi-Arid California Watersheds, Emmanuel Gabet, Noah Fierer, Oliver Chadwick

Faculty Publications

Soil carbon (C), nitrogen (N), and phosphorus (P) are lost from hillslopes in particulate forms through soil erosion. The fate of the eroded C (e.g., sequestration or oxidation) may affect the global C budget, and delivery of N and P to waterbodies can lead to eutrophication. Whereas the magnitude of particulate nutrient losses may be similar to or greater than dissolved losses, it is rarely estimated. We couple a sediment delivery model with measurements of C, N, and P in soil to account explicitly for hillslope sediment transport processes that yield sediment-bound nutrients to fluvial networks. The model is applied …

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Ontologies In Web Personalization, Magdalini Eirinaki, Michalis Vazirgiannis Oct 2005

Ontologies In Web Personalization, Magdalini Eirinaki, Michalis Vazirgiannis

Faculty Publications

No abstract provided.

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The Igipi Ontological Framework: Integrating Gene Interactions With Protein Interactions, Bill Andreopoulos, Aijun An, Xiangji Huang Oct 2005

The Igipi Ontological Framework: Integrating Gene Interactions With Protein Interactions, Bill Andreopoulos, Aijun An, Xiangji Huang

Faculty Publications, Computer Science

No abstract provided.

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Information Outlook, October 2005, Special Libraries Association Oct 2005

Information Outlook, October 2005, Special Libraries Association

Information Outlook, 2005

Volume 9, Issue 10

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Phases Found At Grain Boundary Of Yba2cu3o7-D 50 Nm Films On Srtio3 By Enhanced Anomalous Scattering At O:K, Cu:L2,3 And Ba:M4,5 Edges, Juana Acrivos Sep 2005

Phases Found At Grain Boundary Of Yba2cu3o7-D 50 Nm Films On Srtio3 By Enhanced Anomalous Scattering At O:K, Cu:L2,3 And Ba:M4,5 Edges, Juana Acrivos

Faculty Publications, Chemistry

A new phase is detected within 100micrometers of 24 DEG ab grain boundary (GB) in YBa2Cu3O7-d 50 nm films on SrTiO3 by enhanced (001) anomalous scattering. Site identification and temperature dependence is interpreted using crystallographic weights to distinguish enhanced scattering from total electron yield and fluorescence spectra. The c-axis, c0 indicates that only ortho-I phase is present far from GB, both ortho-I and II phases are present near GB. The phase c0 is constant versus temperature across the transition to superconductivity.

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Enhanced Anomalous Scattering By Superconducting Nanofilms Vs T At O:K, Cu:L2,3 , Ba:M4,5 Edges, Juana Acrivos Sep 2005

Enhanced Anomalous Scattering By Superconducting Nanofilms Vs T At O:K, Cu:L2,3 , Ba:M4,5 Edges, Juana Acrivos

Faculty Publications, Chemistry

Enhanced (001) anomalous scattering by YBa2Cu3O7-δ 50 nm films on SrTiO3 substrates with and without a grain boundary versus temperature is interpreted using crystallographic weights to distinguish it from total electron yield and fluorescence spectra. The power of diffraction enhancement is to ascertain the film oxygen composition from the changes in the c-axis, c0 as the film surface is scanned across the grain boundary, and to determine that c0 is constantversus temperature across the superconducting phase transition.

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A New Pathway For Communicating The 11-Year Solar Cycle Signal To The Qbo, Eugene C. Cordero, Terrence R. Nathan Sep 2005

A New Pathway For Communicating The 11-Year Solar Cycle Signal To The Qbo, Eugene C. Cordero, Terrence R. Nathan

Faculty Publications, Meteorology and Climate Science

[1] The response of the equatorial quasi-biennial oscillation (QBO) to zonal-mean ozone perturbations consistent with the 11-year solar cycle is examined using a 2 1/2 dimensional model of the tropical stratosphere. Unique to this model are wave-ozone feedbacks, which provide a new, nonlinear pathway for communicating solar variability effects to the QBO. Model simulations show that for zonal-mean ozone perturbations representative of solar maximum (minimum), the diabatic heating due to the wave-ozone feedbacks is primarily responsible for driving a slightly stronger (weaker) QBO circulation and producing a slightly shorter (longer) QBO period. These results, which are explained via an analytical …

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Spartan Daily, August 30, 2005, San Jose State University, School Of Journalism And Mass Communications Aug 2005

Spartan Daily, August 30, 2005, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 125, Issue 3

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Optimizing Transmission Time Of Scalable Coded Images In Peer-To-Peer Networks, Xiao Su, Rod Fatoohi, Tao Wang Aug 2005

Optimizing Transmission Time Of Scalable Coded Images In Peer-To-Peer Networks, Xiao Su, Rod Fatoohi, Tao Wang

Faculty Publications

In this paper, we study how to optimize image transmission time in peer-to-peer networks by considering the property of bitstreams generated by image coding algorithms. Images can be either scalable coded or nonscalable coded. Since transmission of nonscalable coded images is well understood, we focus on the transmission of scalable coded images in this paper.Because scalable coding embeds lower bit-rate bitstreams into higher bit-rate bitstreams, there exists a many-to-one relationship between supplying and requesting peers. When a requesting peer asks for an image coded in a particular bit rate, multiple peers with the same image but coded in different bit …

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Investigation Of The Anisotropy Of Dissipation Processes In Single Crystal Of Yba2cu3o7-D System, J Chigvinadze, A. Lashvili, Juana Acrivos, T. Machaidze, T. Wolf Aug 2005

Investigation Of The Anisotropy Of Dissipation Processes In Single Crystal Of Yba2cu3o7-D System, J Chigvinadze, A. Lashvili, Juana Acrivos, T. Machaidze, T. Wolf

Faculty Publications, Chemistry

By means of contactless mechanical method of the measurement of energy losses in superconductors, the anisotropy of dissipation processes has been studied in single crystal high-temperature layered superconductors of Yba2Cu3O7-d system, being in mixed state. The observed anisotropy of energy losses indicates the possibility of the existence of the symmetry of order parameter of dx2-y2 type in these single crystals.

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A Model Search Engine Based On Cluster Analysis Of User Search Terms, Elaine Maytag Nowick, Kent M. Eskridge, Daryl A. Travnicek, Xingchun Chen, Jun Li Jul 2005

A Model Search Engine Based On Cluster Analysis Of User Search Terms, Elaine Maytag Nowick, Kent M. Eskridge, Daryl A. Travnicek, Xingchun Chen, Jun Li

Library Philosophy and Practice (e-journal)

No abstract provided.

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Dimensional Advances For Information Architecture, Joanne Twining Jul 2005

Dimensional Advances For Information Architecture, Joanne Twining

Library Philosophy and Practice (e-journal)

No abstract provided.

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Geo-Referenced Digital Libraries: Experienced Problems Of Purpose And Infrastructure, Ying Liu Jul 2005

Geo-Referenced Digital Libraries: Experienced Problems Of Purpose And Infrastructure, Ying Liu

Library Philosophy and Practice (e-journal)

No abstract provided.

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Mankind's Memory Managers: A New Paradigm Of Library Science, Primoz Bizjak Jul 2005

Mankind's Memory Managers: A New Paradigm Of Library Science, Primoz Bizjak

Library Philosophy and Practice (e-journal)

No abstract provided.

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Hierarchical Gaps And Subject Authority Control Processing : An Assessment, Daniel Canncasciato, Mary Wise Jul 2005

Hierarchical Gaps And Subject Authority Control Processing : An Assessment, Daniel Canncasciato, Mary Wise

Library Philosophy and Practice (e-journal)

No abstract provided.

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Social Aspects Of Information, Felix T. Chu Jul 2005

Social Aspects Of Information, Felix T. Chu

Library Philosophy and Practice (e-journal)

No abstract provided.

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From The Physical Reality To The Virtual Reality In The Library Environment, Markos Dendrinos Jul 2005

From The Physical Reality To The Virtual Reality In The Library Environment, Markos Dendrinos

Library Philosophy and Practice (e-journal)

No abstract provided.

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Librarianship And The Philosophy Of Information, Ken R. Herold Jul 2005

Librarianship And The Philosophy Of Information, Ken R. Herold

Library Philosophy and Practice (e-journal)

No abstract provided.

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Environmental Impact: A Preliminary Citation Analysis Of Local Faculty In A New Academic Program In Environmental And Human Health Applied To Collection Development In An Academic Library, Bill Johnson Jul 2005

Environmental Impact: A Preliminary Citation Analysis Of Local Faculty In A New Academic Program In Environmental And Human Health Applied To Collection Development In An Academic Library, Bill Johnson

Library Philosophy and Practice (e-journal)

No abstract provided.

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A Shift In Teaching Methodology: From Instructor Led To Student Driven Multimedia Instruction, Patricia Backer Jun 2005

A Shift In Teaching Methodology: From Instructor Led To Student Driven Multimedia Instruction, Patricia Backer

Faculty Publications

Multimedia can be a powerful tool in exploring the nature of the world around us, including its technological systems. This paper describes the design, development, and evaluation of self- paced multimedia and web-based modules that are used in an advanced General Education (GE) course in the College of Engineering at San José State University. The design and development cycle of these modules began in 1994 and spanned nine years. The General Education course, Technology and Civilization (TECH 198), is designed to introduce students to the realm of history and usage of technology in society and to increase their awareness of …

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Microgravity Studies Of Aggregation In Particulate Clouds, Todd B. Sauke, J. R. Marshall, J. N. Cuzzi Jun 2005

Microgravity Studies Of Aggregation In Particulate Clouds, Todd B. Sauke, J. R. Marshall, J. N. Cuzzi

Faculty Publications

Aggregation in clouds of submillimeter quartz and volcanic ash particles was studied in microgravity. Particle clouds generated by pulses of air immediately formed electrostatic filamentary aggregates upon cessation of air turbulence. Manual agitation of experiment chambers produced cm-size loose grain clusters which voraciously scavenged free-floating material in their vicinity. A dipole model accounts for these observations. Experimental results have ramifications for the behavior of natural cloud systems and primary accretion of solids in the early solar nebula.

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