Digital Commons Network^™

Inferring Gene Regulatory Networks From A Population Of Yeast Segregants, Chen Chen, Dabao Zhang, Tony R. Hazbun, Min Zhang

Purdue University Libraries Open Access Publishing Fund

Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by consistent selection of regulatory effects at the second stage. Using this approach, we identified subnetworks that were enriched in gene ontology categories, revealing directional regulatory mechanisms controlling …

No Bones About It: How Digital Fabrication Changes Student Perceptions Of Their Role In The Classroom, Alexandria K. Hansen, Jasmine K. Mcbeath, Danielle B. Harlow

Journal of Pre-College Engineering Education Research (J-PEER)

This study used cultural historical activity theory to make meaning of a digital fabrication project situated in the complexity of a classroom. Using an ethnographic perspective, we observed 14 students (aged 13–14) in a middle school’s creative design and engineering class inspired by the Maker Movement. Working with the classroom teacher, a professional stuntman tasked students with fabricating a prosthetic bone for use as a movie prop using their understanding of science, technology, engineering, and mathematics. Teacher interviews and student focus groups revealed differences in perceptions between their science class and engineering class. Additionally, affordances and constraints of the 3D …

Disciplinary Learning From An Authentic Engineering Context, Catherine Langman, Judith Zawojewski, Patricia Mcnicholas, Ali Cinar, Eric Brey, Mustafa Bilgic, Hamidreza Mehdizadeh

Journal of Pre-College Engineering Education Research (J-PEER)

This small-scale design study describes disciplinary learning in mathematical modeling and science from an authentic engineeringthemed module. Current research in tissue engineering served as source material for the module, including science content for readings and a mathematical modeling activity in which students work in small teams to design a model in response to a problem from a client. The design of the module was guided by well-established principles of model-eliciting activities (a special class of problem-solving activities deeply studied in mathematics education) and recently published implementation design principles, which emphasize the portability of model-eliciting activities to many classroom settings.

Two …

Amino Alkynylisoquinoline And Alkynylnaphthyridine Compounds Potently Inhibit Acute Myeloid Leukemia Proliferation In Mice, N Naganna, Clement Opuku-Temeng, Eun Yong Choi, Elizabeth Larocque, Elizabeth T. Chang, Brandon A. Carter-Cooper, Modi Wang, Sandra E. Torregrossa-Allen, Bennett D. Elzey, Rena G. Lapidus, Herman Sintim

Department of Chemistry Faculty Publications

B

ackground: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate drops to b10%. About 30% of AML patients harbor an activating mutation in the tyrosine kinase domain (TKD) of Fms-Like Tyrosine kinase 3 (FLT3) or a FLT3 internal tandem duplication (FLT3-ITD). In- hibitors of FLT3, such as Rydapt that was recently approved by the FDA, have shown good initial response but pa- tients often relapse due to secondary mutations in the …

Examining Science Learning And Attitude By At-Risk Students After They Used A Multimedia-Enriched Problem-Based Learning Environment, Min Liu, Sa Liu, Zilong Pan, Wenting Zou, Chenglu Li

Interdisciplinary Journal of Problem-Based Learning

Most of the previous problem-based learning (PBL) studies have been conducted with gifted or regular education students and have shown successes. However, little research on PBL exists for disadvantaged middle school students, especially students who are considered to be at risk of failing academically. In this study, we examined the use of a multimedia-enriched PBL science environment by at-risk middle school students. The results, using a mixed-methods design, showed that these students significantly improved their science knowledge and attitude toward science after they engaged in PBL learning. While there were no differences in the scores between the genders, the gain …

Creative Integration And Pragmatist Optimism: Dispositions For “The Task Before Us”, Barbara S. Stengel

Education and Culture

How can and will educators in any setting work with young people of all ages to enable them to develop the ability to interrogate—without denigrating—the claims of candidates, the newsmaking of media, the needs of their neighbors, and the fears of their family members? The answer I offer and defend here involves two dispositions—creative integration and pragmatist optimism—that I view as critical to the pursuit of vibrant and viable political democracy. These dispositions are, I argue, necessary to and evidence of the very possibility of a polity worthy of the "democratic" label.

A Learning-Centered Paradigm For Engineering Graphics And Design: Engineering Technology Students' Skill Gains And Capstone Preparation, Rustin Webster

School of Engineering Technology Faculty Publications

This descriptive non-experimental follow-on study investigates the extent to which a learning-centered paradigm in an engineering graphics and design course prepared undergraduate engineering technology (ET) students for senior capstone and how the course impacted vital professional and technical skills. A small 2016 case study (n = 10) showed that the course, which was approximately 5% passive and 95% active learning produced positive skill gains for ET students (Webster 2017). However, this follow-on study was needed largely from the inability of the 2016 case study to 1) identify and/or confirm data trends and 2) fully gauge the students’ preparation for senior …

Probability Of Detection Study For Visual Inspection Of Steel Bridges: Volume 2—Full Project Report, Leslie E. Campbell, Luke R. Snyder, Julie M. Whitehead, Robert J. Connor, Jason B. Lloyd

JTRP Technical Reports

An inspector’s ability to correctly identify surface and internal defects in steel bridge components is critical to protecting public safety. Ensuring that inspectors are properly trained and adequately equipped to detect these defects in locations that are difficult to access and/or in unfavorable environmental conditions must be a high priority. While the Federal Highway Administration and individual state departments of transportation have guidelines for inspector qualifications, trainings, and certifications, there is very little emphasis placed on evaluating or “testing: a given inspector’s capability to characterize defects in the field. As a result, there is also very little, if any, data …

Pavement Acceptance Testing: Risk-Controlled Sampling Strategy, Jiannan Cai, Qingyi Gao, Hyonho Chun, Hubo Cai

JTRP Technical Reports

Acceptance testing is a critical aspect of the quality control and quality assurance (QC/QA) program to ensure the reliable long-term performance of pavement. A typical acceptance testing specification includes acceptable quality characteristics (AQCs), testing methods, number of samples, sample locations, and acceptance criteria. In the current practice, Indiana Department of Transportation (INDOT) accepts pavement by sampling and testing materials with a pre-determined, very low frequency at random locations, leading to a significant problem: testing results are not truly “representative” of the project because sampling is neither based on a statistical foundation, nor on the reliability concept.

This study developed a …

Life-Cycle Cost Analysis For Short- And Medium-Span Bridges, Stefan L. Leiva Maldonado, Mark D. Bowman

JTRP Technical Reports

Life-cycle cost analysis (LCCA) has been defined as a method to assess the total cost of a project. It is a simple tool to use when a single project has different alternatives that fulfill the original requirements. Different alternatives could differ in initial investment, operational and maintenance costs among other long term costs. The cost involved in building a bridge depends upon many different factors. However, long-term cost need to be considered to estimate the overall cost of the project and determine its LCC. Without watchful consideration of the long-term costs and full life-cycle costing, current investment decisions that look …

Network-Level Scheduling Of Road Projects During The Construction Season Considering Network Connectivity, Wubeshet Woldemariam, Augustine Agyemang, Mohammad Miralinaghi, Dulcy M. Abraham, Kumares Sinha

JTRP Technical Reports

INDOT implements several hundred highway projects annually. One of the unintended (and adverse) consequences of road work is the establishment of work zones or full or partial closure of certain road links and the subsequent impairment of network connectivity during the construction season. The temporary reduction in network connectivity can lead to reduced mobility and decreased accessibility to businesses. The user costs incurred during highway construction can be significant, particularly where the affected links have very high traffic volumes or offer few opportunities to detour. Delay also inflicts costs on the non-traveling public, such as when it is necessary to …

Inertial Impedance Of Coalescence During Collision Of Liquid Drops, Krishnaraj Sambath, Vishrut Garg, Sumeet S. Thete, Hariprasad J. Subramani, Osman A. Basaran

School of Chemical Engineering Faculty Publications

The fluid dynamics of the collision and coalescence of liquid drops has intrigued scientists and engineers for more than a century owing to its ubiquitousness in nature, e.g. raindrop coalescence, and industrial applications, e.g. breaking of emulsions in the oil and gas industry. The complexity of the underlying dynamics, which includes occurrence of hydrodynamic singularities, has required study of the problem at different scales – macroscopic, mesoscopic and molecular – using stochastic and deterministic methods. In this work, a multi-scale, deterministic method is adopted to simulate the approach, collision, and eventual coalescence of two drops where the drops as well …

Limitations Of Zt As A Figure Of Merit For Nanostructured Thermoelectric Materials, Xufeng Wang, Mark Lundstrom

Department of Electrical and Computer Engineering Faculty Publications

Thermoelectric properties of nanocomposites are numerically studied as a function of average grain size or nanoparticle density by simulating the measurements as they would be done experimentally. In accordance with previous theoretical and experimental results, we find that the Seebeck coefficient, power factor and figure of merit, zT, can be increased by nanostructuring when energy barriers exist around the grain boundaries or embedded nanoparticles. When we simulate the performance of a thermoelectric cooler with the same material, however, we find that the maximum temperature difference is much less than expected from the given zT. This occurs because the …

Ice Formation Modes During Flow Freezing In A Small Cylindrical Channel, A. Jain, A. Miglani, Y Huang, J. A. Weibel, S V. Garimella

CTRC Research Publications

Freezing of water flowing through a small channel can be used as a nonintrusive flow control mechanism for microfluidic devices. However, such ice valves have longer response times compared to conventional microvalves. To control and reduce the response time, it is crucial to understand the factors that affect the flow freezing process inside the channel. This study investigates freezing in pressure-driven water flow through a glass channel of 500 lm inner diameter using measurements of external channel wall temperature and flow rate synchronized with high-speed visualization. The effect of flow rate on the freezing process is investigated in terms of …

Recognizing Engineering Students’ Funds Of Knowledge: Creating And Validating Survey Measures, Dina Verdín, Jessica M. Smith, Juan Lucena

School of Engineering Education Graduate Student Series

This research base paper examines students who are the first in their families to attend college. Our research seeks to understand the role students’ funds of knowledge makes in first-generation college students’ undergraduate experience. Funds of knowledge are the set of formal/informal knowledge and skills that students learn through family, friends, and communities outside of academic institutions. This paper reports funds of knowledge themes relevant to first-generation college students in engineering and the process of gathering validity evidence to support the funds of knowledge themes.

Using ethnographic and interview data, six themes emerged: connecting experiences, community networks, tinkering knowledge, perspective …

The Value Of Standards For Teaching, Research, And Facilities Use At Princeton And Purdue, Anya C. Bartelmann, Margaret Phillips

Libraries Faculty and Staff Scholarship and Research

This PowerPoint presentation was delivered as part of the 2019 ASME Library Advisory Board Annual Meeting.

Humanities And Social Sciences Dissertation Bibliographies And Collections: The View From A Stem University, Trevor Burrows, Robert S. Freeman, Erla Heyns, Jean-Pierre V. M. Herubel

Libraries Faculty and Staff Scholarship and Research

This study utilized dissertation bibliographies produced at Purdue University in West Lafayette, Indiana, a STEM-oriented university, to ascertain how well Purdue’s Humanities, Social Science, and Education (HSSE) Library supports doctoral research. To examine a critical mass of data, the authors gathered all the bibliographies of dissertations written in 11 disciplines within the College of Liberal Arts in 2011 and 2015. Data for each citation included year of publication, language, format type, and local availability in print or digitally. Revealing disciplinary trends in using sources, this study provided critical information for reconceptualizing the HSSE Library’s orientation to learning and research and …

Bibliometrics For Collection Development? A Study Of The Publishing Habits Of Math Faculty At Three Research Institutions, Nastasha E. Johnson

Libraries Faculty and Staff Presentations

No abstract provided.

Board 51: An Initial Step Towards Measuring First-Generation College Students’ Personal Agency: A Scale Validation, Dina Verdín, Allison Godwin

School of Engineering Education Graduate Student Series

This research paper describes the development of a scale to measure how first-generation college students use engineering as a tool for making a difference in their community and world or personal agency. Personal agency is a capability that every individual holds; it is described by Bandura as an individual’s beliefs about their capabilities to exercise control over events that affect their lives through purposeful and reflective actions. Agentic actions allow students to explore, maneuver and impact their environment for the achievement of a goal or set of goals. This study identifies how cognitive processes of forethought, intention, reactivity, and reflection …

Eager: Broadening Participation Of First-Generation College Student, Jessica M. Smith, Dina Verdín, Juan C. Lucena

School of Engineering Education Graduate Student Series

No abstract provided.

What Spaces Do We Dream Of And What Do They Do With Them? 5 Years Of User Experience In The New Uclouvain Library And Learning Center Of Sciences And Technologies., Frédéric Brodkom

Proceedings of the IATUL Conferences

No abstract provided.

Internet Of Things In Smart Agriculture: Enabling Technologies, Abdul Salam, Syed Shah

Computer Information Technology Faculty Publications

In this paper, an IoT technology research and innovation roadmap for the field of precision agriculture (PA) is presented. Many recent practical trends and the challenges have been highlighted. Some important objectives for integrated technology research and education in precision agriculture are described. Effective IoT based communications and sensing approaches to mitigate challenges in the area of precision agriculture are presented.

A Novel 3d+Mea Approach To Authentic Engineering Education For Teacher Professional Development: Design Principles And Outcomes, Melissa Dyehouse, Adam L. Santone, Zahid Kisa, Ronald L. Carr, Rabieh Razzouk

Journal of Pre-College Engineering Education Research (J-PEER)

This paper describes the design principles and implementation of a novel approach for a K–12 teacher professional development (PD) program. The approach integrates training focused on development of model eliciting activities (MEAs) within authentic engineering design tasks, collaborative 3D model design and fabrication, and inspirational site visits with access to active engineers to enhance understanding of current issues faced by NASA aerospace researchers. Throughout the training, participants collaborated with program staff including engineering, 3D graphics, education, and MEA specialists to develop research-related MEAs with accompanying 3Dprinted manipulatives. The purpose of this article is to provide a framework for engineering education …

Assessing Mechanistic Reasoning: Supporting Systems Tracing, Paul J. Weinberg

Journal of Pre-College Engineering Education Research (J-PEER)

Reasoning about mechanism is central to disciplined inquiry in science and engineering and should thus be one of the foundations of a science, technology, engineering, and mathematics education. In addition, mechanistic reasoning is one of the core competencies listed in the Next Generation Science Standards (NGSS) Engineering Concepts and Practices (NGSS Lead States, 2013). Mechanistic explanations focus on the processes that underlie cause–effect relationships and consider how the activities of system components affect one another.

While some assessment work has been accomplished in engineering education, to date mechanistic reasoning is an area where limited assessment development has been accomplished for …

Selecting And Implementing Leading Edge Technology Services: Library As Partner In The Innovation Ecosystem, Patrick Tod Colegrove

Proceedings of the IATUL Conferences

The practice of libraries – and with it, librarianship – continues to evolve. New technology and services are fundamental to library support of innovation and creativity; deciding which technologies and/or services to implement can be less clear. The overlap of design thinking with best practices of emerging technology and libraries offers a practical approach: real-world examples of success and failure reveal the outlines of an emerging framework for improved selection and implementation of leading-edge technology in the library environment. Novel services and technologies offered by a library that is part makerspace, part accelerator, and full partner in the innovation ecosystem …

Quadcopters Or Linguistic Corpora – Establishing Rdm Services For Small-Scale Data Producers At Big Universities, Göran Hamrin, Viola Voß

Proceedings of the IATUL Conferences

During the IATUL Conference 2017, the authors had many productive exchanges about similari-ties and differences in Swedish and German higher-education libraries. Since research data management (RDM) is an emerging topic on both sides of the Baltic Sea, we find it valuable to compare strategies, services, and workflows to learn from each other’s practices. Aim: In this talk, we aim to compare the practices and needs of small-scale data producers in engineering and the humanities. In particular, we try to answer the following research questions: What kind of data do the small-scale data producers produce? What do these producers need in …

Supporting Research In A Digital World – Positioning The Library On Campus, Ewald Brahms

Proceedings of the IATUL Conferences

The digital world offers new opportunities for university libraries to support research and to position itself on campus. However, open access, open science, and further aspects of ‘openness’ necessitate strategic changes in order to ensure high-quality library services tailored to the customers’ needs. Establishing new partnerships, and developing shared initiatives on as well as off campus enable the library to manage new projects, improve its existing services, and also offer new services. Building on a convincing record of past performances Hildesheim University Library is able to undertake new tasks, and thus to position itself on campus as an innovative and …

Using Virtual Reality To Create Real World Collaborations, Richard Smith, Oliver Bridle

Proceedings of the IATUL Conferences

The Radcliffe Science Library (RSL) is Oxford University’s principle science library and it provides easy access to digital tools to enhance teaching, learning and research. Previous projects have developed lending programmes for e-readers and iPads and introduced a popular 3D printing service. The library’s interest in adapting to disruptive technology and providing innovative tools to support academic projects and exploration of new technologies led us in 2017 to initiate a Virtual Reality (VR) lending programme. University members can now borrow VR Headsets, 360⁰ degree cameras and supplementary equipment free of charge from the RSL. In this paper we describe how …

The Nature Of Teaching: Connecting K-5 Teachers And Students With Nature, Rebecca Busse

Engagement & Service-Learning Summit

No abstract provided.

Hands Of The Future, Inc.: Connecting Youth With Nature, Amee Waltman, Rebecca Busse

Engagement & Service-Learning Summit

No abstract provided.