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Articles 2401 - 2430 of 18457
Full-Text Articles in Entire DC Network
An Examination Of The Current Knowledge Of Contaminants In Mangroves: Hawaii And Globally, Geoffrey Szafranski
An Examination Of The Current Knowledge Of Contaminants In Mangroves: Hawaii And Globally, Geoffrey Szafranski
Environmental Science and Management Professional Master's Project Reports
The geographic range of mangrove forests is shifting quickly as they expand poleward in response to climate change while simultaneously being removed from their native extent to clear space for anthropogenic land-uses. Mangrove forests are also known to be sinks for anthropogenic contamination. Yet contamination research is under-researched in mangrove ecosystems, specifically the environmental fate, effect on biodiversity, and risk to human populations from contamination in the context of these changing conditions requires further research. The goal of this thesis is to address this data gap through analysis of contamination in the literature and through an investigational survey of mangrove …
Exploring The Lexical Profile Of Advanced L2 Writers: Longitudinal Data From The Russian Overseas Flagship Program, William J. Comer
Exploring The Lexical Profile Of Advanced L2 Writers: Longitudinal Data From The Russian Overseas Flagship Program, William J. Comer
World Languages and Literatures Faculty Publications and Presentations
This study explores the lexical profile of essays written by 48 advanced learners of second language (L2) Russian who participated in the Russian Overseas Flagship, an intensive year-long study abroad program, designed to help students reach Interagency Language Roundtable (ILR) Level 3 proficiency in all skills. Using the lexical frequency profile (LFP) and P–Lex as measures of vocabulary sophistication, the study found that over the 9 months of the program, students significantly increased their usage of words from the lowest frequency bands. This adds to the findings of Hacking and Tschirner (2017) that knowledge of lexical items at the 3,000–5,000 …
Racial, Ethnic, And Socioeconomic Disparities In Trajectories Of Morbidity Accumulation Among Older Americans, Annamarie S. O'Neill, Jason T. Newsom, Miriam R. Elman, Em F. Trubits, Multiple Additional Authors
Racial, Ethnic, And Socioeconomic Disparities In Trajectories Of Morbidity Accumulation Among Older Americans, Annamarie S. O'Neill, Jason T. Newsom, Miriam R. Elman, Em F. Trubits, Multiple Additional Authors
Psychology Faculty Publications and Presentations
Introduction
Multimorbidity, the presence of multiple chronic health conditions, generally starts in middle and older age but there is considerable heterogeneity in the trajectory of morbidity accumulation. This study aimed to clarify the number of distinct trajectories and the potential associations between race/ethnicity and socioeconomic status and these trajectories.
Methods
Data from 13,699 respondents (age ≥51) in the Health and Retirement Study between 1998 and 2016 were analyzed with growth mixture models. Nine prevalent self-reported morbidities (arthritis, cancer, cognitive impairment, depressive symptoms, diabetes, heart disease, hypertension, lung disease, stroke) were summed for the morbidity count.
Results
Three trajectories of morbidity …
The Satisfaction Clause In Publishing Agreements: A Case Study Of Its Purpose, Controversy, And Future, Maliea Ruby
The Satisfaction Clause In Publishing Agreements: A Case Study Of Its Purpose, Controversy, And Future, Maliea Ruby
Book Publishing Final Research Papers
This research paper examines the satisfaction clause included in publishing contracts, the reason for controversy surrounding it, and what the future may look like for it. This is accomplished by looking at the history of the clause, how it functions in publishing contracts, and three major court cases centered around it. The satisfaction clause allows a client seeking a job done to determine whether the work is satisfactory to them. Much of the time these contracts are written to favor the client, part of the reason for its controversial status. In the context of publishing, the satisfaction clause is important …
Trends In Young Adult Literature: A Quantitative Approach To Characterizing The New York Times Young Adult Bestsellers Of 2020, 2021, And 2022, Anna Wehmeier Giol
Trends In Young Adult Literature: A Quantitative Approach To Characterizing The New York Times Young Adult Bestsellers Of 2020, 2021, And 2022, Anna Wehmeier Giol
Book Publishing Final Research Papers
Understanding how a book becomes a bestseller is one of the biggest mysteries in the publishing industry. This research paper focuses on YA bestsellers and uses a quantitative methodology to try to solve the mystery. Its main objectives are to (1) review the current trends in YA literature and (2) find patterns and similarities in the text of YA bestsellers. By building a dataset and analyzing the 175 books featured in the “Young Adult Hardcover” bestseller list of the New York Times for 2020, 2021, and 2022, the study shows that YA bestsellers share characteristics and patterns, such as the …
Inference And Reconstruction Of The Heimdallarchaeial Ancestry Of Eukaryotes, Laura Eme, Daniel Tamarit, Eva F. Caceres, Courtney W. Stairs, Valerie De Anda, Max E. Schön, Kiley W. Seitz, Nina Dombrowski, Anna-Louise Reysenbach, Multiple Additional Authors
Inference And Reconstruction Of The Heimdallarchaeial Ancestry Of Eukaryotes, Laura Eme, Daniel Tamarit, Eva F. Caceres, Courtney W. Stairs, Valerie De Anda, Max E. Schön, Kiley W. Seitz, Nina Dombrowski, Anna-Louise Reysenbach, Multiple Additional Authors
Biology Faculty Publications and Presentations
In the ongoing debates about eukaryogenesis—the series of evolutionary events leading to the emergence of the eukaryotic cell from prokaryotic ancestors— members of the Asgard archaea play a key part as the closest archaeal relatives of eukaryotes1. However, the nature and phylogenetic identity of the last common ancestor of Asgard archaea and eukaryotes remain unresolved2–4. Here we analyse distinct phylogenetic marker datasets of an expanded genomic sampling of Asgard archaea and evaluate competing evolutionary scenarios using state-of-the-art phylogenomic approaches. We find that eukaryotes are placed, with high confidence, as a well-nested clade within Asgard archaea and as a sister lineage …
Telemedicine Among Adults Living In America During The Covid-19 Pandemic, Man Hung, Monica Ocampo, Benjamin Raymond, Amir Mohajeri, Martin S. Lipsky
Telemedicine Among Adults Living In America During The Covid-19 Pandemic, Man Hung, Monica Ocampo, Benjamin Raymond, Amir Mohajeri, Martin S. Lipsky
Institute on Aging Publications
Background and Objectives Telemedicine can expand healthcare access to populations, but relying on technology risks a digital divide. Therefore, it is important to understand who utilizes telemedicine. This study explores telemedicine usage across socio-demographic groups in the United States during COVID-19. Methods Data came from the Household Pulse Survey (HPS) between 14 April 2021, to 11 April 2022. HPS is a rapid online response survey that assesses household experiences during COVID-19. We calculated descriptive statistics and used cross-correlation to test each pair of the time series curves. Results High school graduates used the least telemedicine (20.58%), while those with some …
Evolution Of Eddy Viscosity In The Wake Of A Wind Turbine, Luis Martínez-Tossas, Juliaan Bossuyt, Nicholas Hamilton, Raul Bayoan Cal
Evolution Of Eddy Viscosity In The Wake Of A Wind Turbine, Luis Martínez-Tossas, Juliaan Bossuyt, Nicholas Hamilton, Raul Bayoan Cal
Mechanical and Materials Engineering Faculty Publications and Presentations
The eddy viscosity hypothesis is a popular method in wind turbine wake modeling for estimating turbulent Reynolds stresses. We document the downstream evolution of eddy viscosity in the wake of a wind turbine from experimental and large-eddy-simulation data.Wake eddy viscosity is isolated from its surroundings by subtracting the inflow profile, and the driving forces are identified in each wake region. Eddy viscosity varies in response to changes in turbine geometry and nacelle misalignment with larger turbines generating stronger velocity gradients and shear stresses. We propose a model for eddy viscosity based on a Rayleigh distribution. Model parameters are obtained from …
Relationship Between Chinese Herbal Medicine Use And Risk Of Sjögren’S Syndrome In Patients With Rheumatoid Arthritis: A Retrospective, Population-Based, Nested Case-Control Study, Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Relationship Between Chinese Herbal Medicine Use And Risk Of Sjögren’S Syndrome In Patients With Rheumatoid Arthritis: A Retrospective, Population-Based, Nested Case-Control Study, Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Counselor Education Faculty Publications and Presentations
Background and Objectives: Sjögren’s Syndrome (SS) is a common extra-articular feature among subjects with rheumatoid arthritis (RA). While Chinese herbal medicine (CHM) has been used to treat symptoms of RA for many years, few studies have examined its efficacy in guarding against the SS onset. This study aimed to compare risk of SS for RA patients with and without use of CHM. Materials and Methods: Data obtained for this nested case-control study were retrieved from Taiwanese nationwide insurance database from 2000–2013. Cases with SS claims were defined and matched to two randomly selected controls without SS from the recruited RA …
Comparison Of General Population Vs. U.S. Military Veterans Eating Disorder Prevalence, Micah Callahan
Comparison Of General Population Vs. U.S. Military Veterans Eating Disorder Prevalence, Micah Callahan
University Honors Theses
Eating disorders disrupt the psychological wellbeing, work ability and daily functioning of many individuals. There is currently no data to compare the prevalence of eating disorders in the general public compared to the military population. The hypothesis was that the military population would be significantly higher in prevalence compared to the general population within the general eating disorder, subcategories of eating disorders and between sex. To analyze the data collected from two studies, sixteen two-proportion Z tests were conducted to determine if the proportions of DSM-V eating disorders differed within and between sex for total incidence and sub-category incidence for …
The People’S Social Epi Project: Pdx With Ryan Petteway, Ryan J. Petteway
The People’S Social Epi Project: Pdx With Ryan Petteway, Ryan J. Petteway
PDXPLORES Podcast
In this episode of PDXPLORES, Ryan J. Petteway, Associate Professor at the Oregon Health & Science University-Portland State University School of Public Health, discusses the research behind The People's Social Epi Project: PDX. Providing a counternarrative to the settler-colonial and racial capitalist practices of traditional epidemiological research on health inequities, Petteway's PSEP: PDX initiative is a portfolio of three projects centering around youth-led participatory research, music, and poetry. PSEP: PDX seeks to "center the margins'' to advance health and epistemic justice.
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Design And Analysis Of High Performance Magnetic Gears For Magnetomechanical Thrusters, Ho Yin Wong
Design And Analysis Of High Performance Magnetic Gears For Magnetomechanical Thrusters, Ho Yin Wong
Dissertations and Theses
This dissertation is devoted to investigating the performance potential of coaxial radial flux modulating magnetic gears for use in propulsive thruster applications. The research has focused on studying magnetic gear designs suitable for use in electric aircraft drivetrains and electric boat thrusters. Consequent pole, flux concentration and Halbach rotor magnetic gear typologies have been analyzed and compared with respect to their torque density performance for the first time. It is shown that the Halbach rotor magnetic gear holds the greatest potential with respect to achieving volumetric and mass torque densities parity with an equivalent mechanical gear.
A high volumetric torque …
Toward Efficient Rendering: A Neural Network Approach, Qiqi Hou
Toward Efficient Rendering: A Neural Network Approach, Qiqi Hou
Dissertations and Theses
Physically-based image synthesis has attracted considerable attention due to its wide applications in visual effects, video games, design visualization, and simulation. However, obtaining visually satisfactory renderings with ray tracing algorithms often requires casting a large number of rays and thus takes a vast amount of computation. The extensive computational and memory requirements of ray tracing methods pose a challenge, especially when running these rendering algorithms on resource-constrained platforms, and impede their applications that require high resolutions and refresh rates. This thesis presents three methods to address the challenge of efficient rendering.
First, we present a hybrid rendering method to speed …
Reporting Rape: Stigmatizing Reactions To Survivors Who Seek Accountability, Tessa L. Dover, Alyssa Marie Glace Maryn
Reporting Rape: Stigmatizing Reactions To Survivors Who Seek Accountability, Tessa L. Dover, Alyssa Marie Glace Maryn
Psychology Faculty Publications and Presentations
Rape survivors face stigma when disclosing their experiences. We hypothesized that a rape survivor who formally reports their rape would experience more stigma than one who does not, and that this effect will be stronger when the perceiver is a man or low in support for sexual consent. Across two studies using self-report, observational, and psychophysiological measures, we found that a reporting survivor was seen more negatively than an identical survivor who did not report their rape. Men and those low in support for sexual consent also responded more negatively to the survivor. Implications of these findings are discussed.
Webinar: Planning And Development In Gateway Communities, Post Covid, Philip Stoker
Webinar: Planning And Development In Gateway Communities, Post Covid, Philip Stoker
TREC Webinar Series
Gateway communities are the small towns outside of national parks, forests, scenic rivers, and ski resorts. This presentation will highlight the housing, transportation, and development challenges that these communities faced in the aftermath of the COVID 19 pandemic. Our study captured the perspectives of over 200 communities using a questionnaire and case study approach. We present these results and highlight the innovative strategies that these communities are using to address their housing and transportation challenges.
Kurdish Filmmaking In Turkey: History And Narratives, Omar Sadik
Kurdish Filmmaking In Turkey: History And Narratives, Omar Sadik
Dissertations and Theses
This research investigates the history and politics of cultural production by examining Kurdish filmmaking in Turkey. Sadik provide an analysis of contemporary films and filmmakers to explore how Kurdish cinema in Turkey is situated in broader, global political-economic structures. By examining this important case through the lens of history and memory, Sadik clarify how production and aesthetics in Kurdish cinema point to important systemic processes. Sadik uses three main research strategies in this study: a historical survey of Kurds in Turkey, an analysis of ten semi-structured interviews with contemporary Kurdish directors and an analysis of films directed by Kurdish filmmakers …
Plantation Pasts, Plantation Futures: Resisting Zombie Water Infrastructures In Maui, Hawai'i, Kelly Kay, Chris Knudson, Alida Cantor
Plantation Pasts, Plantation Futures: Resisting Zombie Water Infrastructures In Maui, Hawai'i, Kelly Kay, Chris Knudson, Alida Cantor
Geography Faculty Publications and Presentations
Sugar plantations have fundamentally shaped water use in Maui, Hawai’i for over 100 years, with tremendous resulting impacts on ecosystems and Native Hawaiian communities. In this paper, we build on literature on the plantationocene and the political lives of infrastructure to examine plantation irrigation infrastructure. We center Maui’s vast water conveyance ditch system as a means of understanding how infrastructure continues plantation logics into the present, considering both the physical ditches themselves as well as the laws and politics which support continued water extraction. We also consider infrastructural futures, highlighting ongoing efforts of communities seeking water justice via infrastructural control.
Uncertainty Quantification And Fragility Development Of Deteriorating Rc Bridge Piers, Ayush Bhandari
Uncertainty Quantification And Fragility Development Of Deteriorating Rc Bridge Piers, Ayush Bhandari
Dissertations and Theses
Corrosion can reduce structural capacity and increase the risk of bridge damage/failure under extreme events. The impact of corrosion on seismic fragility of bridges has been well studied. However, the methodology used in most existing studies requires detailed information on the structural design and condition of a bridge, which is a major hindrance in conducting seismic risk assessment for a large population of bridges. Furthermore, existing studies do not adequately address the time-dependency of uncertainties associated with fragility curve development. This study presents a methodology to generate time-dependent seismic fragility curves for deteriorating highway bridges based only on the limited …
Tools For Quantifying Bacterial Motility Using Digital Holographic Microscopy As Applied To Studying The Simulated Microgravity Environment, Jacqueline Marie Acres
Tools For Quantifying Bacterial Motility Using Digital Holographic Microscopy As Applied To Studying The Simulated Microgravity Environment, Jacqueline Marie Acres
Dissertations and Theses
Digital holographic microcopy (DHM) is a label-free technique that has gained attention in recent years as a tool for volumetric imaging. One application of DHM is for the study of microbial motility with the advantage being that organisms may freely move within their environment. Images created from DHM are in the form of holograms. Holograms are time recordings showing XY information with the Z information contained within. Z information can be retrieved from the holograms directly through a variety of numerical techniques or through reconstruction. Datasets generated from DHM are large and processing remains a challenging task. Here, we show …
An Exploration Of The Relationship Between Disability Status Disclosure, Accommodation Use, And Student Success: Curricular And Co-Curricular Implications, Kaela Marie Parks
An Exploration Of The Relationship Between Disability Status Disclosure, Accommodation Use, And Student Success: Curricular And Co-Curricular Implications, Kaela Marie Parks
Dissertations and Theses
Colleges and universities rely on the individualized accommodation process to ensure access for students with disabilities, however, there is ample evidence that educational inequity is pervasive. This study used a critical and comparative quantitative methodology (n=6,500) to investigate data from a large urban community college, analyzing the relationship between final grades and accommodation eligibility and use across academic disciplines and curricular modalities (in-person vs. on-line) to identify implications for the academic success of students with disabilities. Results indicate disability inequity varies across racial identity groups and racial inequity persists across disability status groups. Results also indicate that accommodation may be …
Family–Teacher Relationships And Child Engagement In Early Care And Education, Hillary Lewis, Shannon T. Lipscomb, Bridget E. Hatfield, Roberta B. Weber, Beth L. Green, Lindsey B. Patterson
Family–Teacher Relationships And Child Engagement In Early Care And Education, Hillary Lewis, Shannon T. Lipscomb, Bridget E. Hatfield, Roberta B. Weber, Beth L. Green, Lindsey B. Patterson
Center for Improvement of Child and Family Services Publications
Young children’s positive interactions with teachers and peers in early care and education (ECE) settings support the development of their social and academic skills. Identifying malleable factors that contribute to children’s positive engagement in these interactions is important in supporting early development. The current study examines one potential malleable factor that could be bolstered through supports for families and teachers alike: family–teacher relationships. We investigate associations between three specific domains of family–teacher relationships and children’s engagement in ECE, so that findings are specific and relevant to intervention. We examine data from Oregon’s Quality Rating Improvement System Validation Study; a diverse …
Faculty Senate Monthly Packet March 2023, Portland State University Faculty Senate
Faculty Senate Monthly Packet March 2023, Portland State University Faculty Senate
Faculty Senate Monthly Packets
The March 6, 2023 Monthly packet includes the March agenda and appendices and the Faculty Senate minutes and attachments from the meeting held February 6, 2023.
The Power Of Algorithms And Big Data: A Marketing Perspective On Consumer Manipulation In Business, Jordan C'Rene Reuille-Dupont
The Power Of Algorithms And Big Data: A Marketing Perspective On Consumer Manipulation In Business, Jordan C'Rene Reuille-Dupont
University Honors Theses
In marketing, predictive analytics molds big data into tools that can create demographics, target pleasurable neuromodulator chemicals like dopamine, and influence individual and societal behavior patterns. Professionals and scholars alike can use machine-based computation to transform big data into usable knowledge that accurately represents and tracks human behavior. In the past couple of decades this has led to the acceleration of the attention economy and has fueled the age of information. It has pushed countries to not only enforce new laws and regulations, but also race to secure control over data science technologies. The research for this thesis will ultimately …
Patients' Willingness To Accept Social Needs Navigation After In-Person Versus Remote Screening, Anna Louise Steeves-Reece, Melinda Marie Davis, Jean Hiebert Larson, Zoe Major-Mcdowall, Anne Elizabeth King, Christina Nicolaidis, Bruce Goldberg, Dawn Michele Richardson, Stephan Lindner
Patients' Willingness To Accept Social Needs Navigation After In-Person Versus Remote Screening, Anna Louise Steeves-Reece, Melinda Marie Davis, Jean Hiebert Larson, Zoe Major-Mcdowall, Anne Elizabeth King, Christina Nicolaidis, Bruce Goldberg, Dawn Michele Richardson, Stephan Lindner
OHSU-PSU School of Public Health Faculty Publications and Presentations
Social needs screening and referral interventions are increasingly common in health care settings. Although remote screening offers a potentially more practical alternative to traditional in-person screening, there is concern that screening patients remotely could adversely affect patient engagement, including interest in accepting social needs navigation.
Examining Mesopredator Detections In The Portland Metropolitan Area, Hunter Storm
Examining Mesopredator Detections In The Portland Metropolitan Area, Hunter Storm
University Honors Theses
Mesopredators--medium-sized predators such as coyote (Canis latrans), common raccoon (Procyon lotor), and Virginia opossum (Didelphis virginiana)--are well established in cities and live closely with humans. However, we still know relatively little about these animals' habitat selection and behavior as they navigate urban space.
In collaboration with the nationwide Urban Wildlife Information Network (UWIN), we established 27 monitoring sites spanning 50 km of the Portland metropolitan area. Using motion-triggered camera traps active during spring 2022 we collected presence and absence data for three non-domestic mesopredator species: coyote, raccoon, and opossum. Using 40 landscape and sociodemographic …
Navigating The Transition: Strategies For Supporting The Success Of At-Risk Youth From Middle School To High School And Beyond, Jessica L. Hlavinka
Navigating The Transition: Strategies For Supporting The Success Of At-Risk Youth From Middle School To High School And Beyond, Jessica L. Hlavinka
University Honors Theses
It has been demonstrated that small class sizes are beneficial for at-risk students transferring to high school. With fewer students, teachers are better able to give personalized attention and assistance, which can encourage students' engagement and motivation to study. Small class numbers can also foster a feeling of community and belonging, which is essential for at-risk students who may feel alienated at school. Also shown to be successful in assisting at-risk adolescents with the transition to high school are mentoring programs. High school students can get assistance and support from mentors as they negotiate the obstacles of the academic environment. …
The Grass Is Always Greener: Analyzing Crime Concentration And Specialization In Urban Greenspace Environs, Cheyenne Pamela Hodgen, Kathryn Wuschke
The Grass Is Always Greener: Analyzing Crime Concentration And Specialization In Urban Greenspace Environs, Cheyenne Pamela Hodgen, Kathryn Wuschke
Criminology and Criminal Justice Faculty Publications and Presentations
Greenspaces play an important role in the urban landscape, with prior research suggesting that they are associated with numerous health and social benefits for residents. Despite this, research conflicts regarding the relationship between greenspaces and crime, with some studies finding these locations to be criminogenic and others finding them to be protective against local crime. This study examines this relationship in Portland, Oregon, considering different greenspace types as well as different crime types. Further, this study presents a novel methodological adaption to measure crime concentration and specialization around discrete location types by integrating a street network buffer into the standard …
Rural Gentrification And The Spillover Effect: Integrated Transportation, Housing, And Land Use Challenges And Strategies In Gateway Communities, Danya Rumore, Philip Stoker
Rural Gentrification And The Spillover Effect: Integrated Transportation, Housing, And Land Use Challenges And Strategies In Gateway Communities, Danya Rumore, Philip Stoker
TREC Final Reports
Small towns and cities near national parks, public lands, and other natural amenities throughout the West are experiencing rapid growth and increased visitation. These “gateway communities” comprise a significant portion of the rural West, constituting about 31% of all communities and more than 60% of those under 25,000 people. Our prior NITC-funded research shows that growth and increased tourism create a range of “big city challenges” for gateway communities, particularly a significant increase in housing prices, which pushes the local workforce to outlying areas and other rural communities. As a result, despite being small towns, many developed gateway communities have …
Microbial Motility At The Bottom Of North America: Digital Holographic Microscopy And Genomic Motility Signatures In Badwater Spring, Death Valley National Park, Carl Snyder, Jakob P. Centlvre, Shrikant Bhute, Jay Nadeau, Multiple Additional Authors
Microbial Motility At The Bottom Of North America: Digital Holographic Microscopy And Genomic Motility Signatures In Badwater Spring, Death Valley National Park, Carl Snyder, Jakob P. Centlvre, Shrikant Bhute, Jay Nadeau, Multiple Additional Authors
Physics Faculty Publications and Presentations
Motility is widely distributed across the tree of life and can be recognized by microscopy regardless of phylogenetic affiliation, biochemical composition, or mechanism. Microscopy has thus been proposed as a potential tool for detection of biosignatures for extraterrestrial life; however, traditional light microscopy is poorly suited for this purpose, as it requires sample preparation, involves fragile moving parts, and has a limited volume of view. In this study, we deployed a field-portable digital holographic microscope (DHM) to explore microbial motility in Badwater Spring, a saline spring in Death Valley National Park, and complemented DHM imaging with 16S rRNA gene amplicon …
Purinergic Receptors In Lung Disease, Emily Mize
Purinergic Receptors In Lung Disease, Emily Mize
University Honors Theses
Purinergic receptors regulate a wide range of physiological processes including neurotransmission, inflammation, and pulmonary function. This review examines the role of purinergic receptor subtypes in the lung with a focus on their relevance to disease and potential as therapeutic targets in future drug development.