Digital Commons Network^™

Synthesis And Characterization Of Glyconanomaterials, And Their Applications In Studying Carbohydrate-Lectin Interactions, Xin Wang

Dissertations and Theses

This dissertation focuses on the synthesis and characterization of glyconanomaterials, as well as their applications in studying carbohydrate-protein interactions. A new and versatile method for coupling underivatized carbohydrates to nanomaterials including gold and silica nanoparticles was developed via the photochemically induced coupling reaction of perfluorophenylazide (PFPA). A wide range of carbohydrates including mono-, oligo- and poly-saccharides were conjugated to the nanoparticles with high yields and efficiency. New analytical methods were developed to determine the binding affinities of glyconanoparticles (GNPs) with lectins; these include fluorescence-based competition assay, dynamic light scattering (DLS) and isothermal titration calorimetry (ITC). Results showed that the multivalent …

"Outing" Queer Issues In Teacher Preparation Programs: How Pre-Service Teachers Experience Sexual And Gender Diversity In Their Field Placements, Olivia Jo Murray

Dissertations and Theses

Currently in the United States there are more than 4 million lesbian, gay, bisexual, and transgender (LGBT) students in K-12 public schools (Bochenek, Brown, & Human Rights Watch, 2001). Despite the prevalence of LGBT youth and the diversification of family populations, teacher preparation programs rarely acknowledge "queer" aspects of multiculturalism (Letts, 2002). As a result, a majority of K-12 educators enter the field of teaching unwilling and/or unprepared to engage with queer issues as they relate to students and families, curriculum, and instruction. The culture of silence around homosexuality can put queer youth at risk and deter school stakeholders from …

Tropical Salvage: From Recession To Expansion, Scott Marshall, Lisa Peifer, Erin Ferrigno

Business Faculty Publications and Presentations

Tim O’Brien, founder of Tropical Salvage, was preparing for another warehouse clearance sale of his unique, handcrafted hardwood furniture. It had been an enormously challenging year and it was important to reduce inventory before the next container arrived from Indonesia. The market for fine furniture had begun to decline steadily in early 2008 following the stock market crash of the prior September. The company survived a difficult period, but not without suffering a decline in sales. O’Brien had spent ten years building a sustainable business model based on environmental stewardship, worker empowerment and unique, high quality product. As the economy …

Burgerville: Sustainability And Sourcing In A Qsr Supply Chain, Darrell Brown, Phil Berko, Patrick Dedrick, Brie Hilliard, Joshua Pfleeger

Business Faculty Publications and Presentations

Jack Graves is considering buying chicken. More precisely, Jack is considering where to buy chicken. He needs to make a recommendation to the purchasing team soon, and the decision is complicated. Jack is a long-time employee of the Burgerville restaurant chain, a quick-serve restaurant chain in the Northwest USA. Burgerville prides itself in being true to its long-held values while maintaining profitability and growth. Graves’ primary job at Burgerville is to assure that the company’s values are embedded in all its actions, including its relationships to its supply chain. His current concern is the dilemma of which values to promote. …

Quantitative Carré Differential Interference Contrast Microscopy To Assess Phase And Amplitude, Donald D. Duncan, David G. Fischer, Amanda Dayton, Scott A. Prahl

Electrical and Computer Engineering Faculty Publications and Presentations

We present a method of using an unmodified differential interference contrast microscope to acquire quantitative information on scatter and absorption of thin tissue samples. A simple calibration process is discussed that uses a standard optical wedge. Subsequently, we present a phase-stepping procedure for acquiring phase gradient information exclusive of absorption effects. The procedure results in two-dimensional maps of the local angular (polar and azimuthal) ray deviation. We demonstrate the calibration process, discuss details of the phase-stepping algorithm, and present representative results for a porcine skin sample.

Escherichia Coli Fpg Glycosylase Is Nonrendundant And Required For The Rapid Global Repair Of Oxidized Purine And Pyrimidine Damage In Vivo, Brandy J. Schalow, Charmain T. Courcelle, Justin Courcelle

Biology Faculty Publications and Presentations

Endonuclease (Endo) III and formamidopyrimidine-N-glycosylase (Fpg) are two of the predominant DNA glycosylases in Escherichia coli that remove oxidative base damage. In cell extracts and purified form, Endo III is generally more active toward oxidized pyrimidines, while Fpg is more active towards oxidized purines. However, the substrate specificities of these enzymes partially overlap in vitro. Less is known about the relative contribution of these enzymes in restoring the genomic template following oxidative damage. In this study, we examined how efficiently Endo III and Fpg repair their oxidative substrates in vivo following treatment with hydrogen peroxide. We found …

Collaboration Strategies In Non-Traditional Cbpr Partnerships: Lessons From An Academic-Community Partnership With Autistic Self-Advocates, Christina Nicolaidis, Dora Raymaker, Katherine Mcdonald, Sebastian Dern, Elesia Ashkenazy, Cody Boisclair, Scott Robertson, Amelia E.V. Baggs

School of Social Work Faculty Publications and Presentations

Background: Most community-based participatory research (CBPR) projects involve local communities defined by race, ethnicity, geography, or occupation. Autistic self-advocates, a geographically dispersed community defined by disability, experience issues in research similar to those expressed by more traditional minorities.

Objectives: We sought to build an academic-community partnership that uses CBPR to improve the lives of people on the autistic spectrum.

Methods: The Academic Autistic Spectrum Partnership in Research and Education (AASPIRE) includes representatives from academic, self-advocate, family, and professional communities. We are currently conducting several studies about the health care experiences and well-being of autistic adults.

Lessons Learned: We have learned …

The Influence Of Military Culture And Veteran Worldviews On Mental Health Treatment: Practice Implications For Combat Veteran Help-Seeking And Wellness, Eugenia Weiss, Jose E. Coll

School of Social Work Faculty Publications and Presentations

The influence of military cultural values consisting of unit cohesion (or the subordination of individual needs over the needs of the collective)the devotion to duty and to the mission,stoicism (emotional restraint)and the importance of adhering to the chain of command become guiding belief systems for military personnel.In fact,military culture has been recognized as a distinct sub-culture of American civilian society.

Genome-Wide Detection Of Novel Regulatory Rnas In E. Coli, Rahul Raghavan, Eduardo Groisman, Howard Ochman

Biology Faculty Publications and Presentations

The intergenic regions in bacterial genomes can contain regulatory leader sequences and small RNAs (sRNAs), which both serve to modulate gene expression. Computational analyses have predicted the presence of hundreds of these noncoding regulatory RNAs in Escherichia coli; however, only about 80 have been experimentally validated. By applying a deep-sequencing approach, we detected and quantified the vast majority of the previously validated regulatory elements and identified 10 new sRNAs and nine new regulatory leader sequences in the intergenic regions of E. coli. Half of the newly discovered sRNAs displayed enhanced stability in the presence of the RNA-binding protein …

Strategies For Labeling Proteins With Paracest Agents, Olga Vasalatiy, Piyu Zhao, Mark Woods, Andrei Marconescu, Aminta Castillo-Muzquiz, Philip Thorpe, Garry Kiefer, A. Dean Sherry

Chemistry Faculty Publications and Presentations

Reactive surface lysine groups on the chimeric monoclonal antibody (3G4) and on human serum albumin (HSA) were labeled with two different PARACEST chelates. Between 7.4 – 10.1 chelates were added per 3G4 molecule and between 5.6 – 5.9 chelates per molecule of HSA, depending upon which conjugation chemistry was used. The immunoreactivity of 3G4 as measured by ELISA assays was highly dependent upon the number of attached chelates: 88% immunoreactivity with 7.4 chelates per antibody versus only 17% immunoreactivity with 10.1 chelates per antibody. Upon conjugation to 3G4, the bound water lifetime of Eu-1 increased only marginally, up from …

Imaging The Extracellular Ph Of Tumors By Mri After Injection Of A Single Cocktail Of T1 And T2 Contrast Agents, Gary V. Martinez, Xiaomeng Zhang, María L. García-Martín, David L. Morse, Mark Woods, A. Dean Sherry, Robert J. Gillies

Chemistry Faculty Publications and Presentations

The extracellular pH (pH(e) ) of solid tumors is acidic, and there is evidence that an acidic pH(e) is related to invasiveness. Herein, we describe an MRI single-infusion method to measure pH(e) in gliomas using a cocktail of contrast agents (CAs). The cocktail contained gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (GdDOTA-4AmP) and dysprosium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetrakis(methylenephosphonic acid) (DyDOTP), whose effects on relaxation are sensitive and insensitive to pH, respectively. The Gd-CA dominated the spin-lattice relaxivity ΔR(1) , whereas the Dy-CA dominated the spin-spin relaxivity ΔR(2)*. The ΔR(2)* effects were used to determine the pixel-wise concentration of [Dy] which, in turn, was used to calculate a value for [Gd] …

Complexity Through Recombination: From Chemistry To Biology, Niles Lehman, Carolina Diaz Arenas, Wesley A. White, Francis J. Schmidt

Chemistry Faculty Publications and Presentations

Recombination is a common event in nature, with examples in physics, chemistry, and biology. This process is characterized by the spontaneous reorganization of structural units to form new entities. Upon reorganization, the complexity of the overall system can change. In particular the components of the system can now experience a new response to externally applied selection criteria, such that the evolutionary trajectory of the system is altered. In this work we explore the link between chemical and biological forms of recombination. We estimate how the net system complexity changes, through analysis of RNA-RNA recombination and by mathematical modeling. Our results …

Interview With Brendan Phillips, Sisters Of The Road, 2010 (Audio), Brendan Phillips

All Sustainability History Project Oral Histories

Interview of Brendan Phillips by Brandon Green in Portland, Oregon on December 8th, 2010.

The interview index is available for download.

Interview With Dan Mcfarling, Aorta, 2010 (Audio), Dan Mcfarling

All Sustainability History Project Oral Histories

Interview of Dan McFarling by Andrew Scanlan at Union Station, Portland, Oregon on December 1st, 2010.

The interview index is available for download.

Faculty Senate Monthly Packet December 2010, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The December 2010 Monthly packet includes the December agenda and appendices and the Faculty Senate minutes and attachments from the meeting held November 2010

Interview With Michael O'Brien, Osd, 2010 (Audio), Michael O'Brien

All Sustainability History Project Oral Histories

Interview of Michael O'Brien by Ian Caputo in North Portland, Oregon on November 22nd, 2010.

The interview index is available for download.

Interview With Brighton West, Friends Of Trees, 2010 (Audio), Brighton West

All Sustainability History Project Oral Histories

Interview of Brighton West by Brigitta Bazso at Portland State University on November 18th, 2010.

The interview index is available for download.

Interview With Renee Loveland, Gerding Edlen, 2010 (Audio), Renee Loveland

All Sustainability History Project Oral Histories

Interview of Renee Loveland by Jena Orr at Gerding Edlen, Portland, Oregon on November 17th, 2010.

The interview index is available for download.

A Look Into The Future Of Wireless Mobile Communication Technologies, Jisun Kim, Tugrul Unsal Daim, Timothy R. Anderson

Engineering and Technology Management Faculty Publications and Presentations

The number of wireless mobile communication service subscribers has reached 4.6 billion worldwide in 2009, and mobile revenues are expected to be over $1 trillion around 2012 according to the International Telecommunication Union (ITU) (ITU, 2010). A significant number of studies have been done to forecast the growing market and evaluate the new generation technology, the Beyond 3 Generation (B3G). However, there is no study forecasting when any of these new technologies will be commercialized. This paper presents a technical framework for forecasting the commercialization timeline of B3G technologies and provides insight on technology trajectories from 1G to 4G. The …

X, Emily Ford

Library Faculty and Staff Publications and Presentations

The author focuses on the issue of undisclosed publications, by which she means works published under pseudonyms or anonymously. The author comments on the proliferation of anonymity in the era of the Internet, saying that technology allows people to be not accountable for their actions and to break social contracts in the scholarly world. The author uses the example of the library field and discusses peer review and professional discourse.

The Cyclin E Regulator Cullin 3 Prevents Mouse Hepatic Progenitor Cells From Becoming Tumor-Initiating Cells, Uta Kossatz, Kai Breuhahn, Benita Wolf, Matthias Hardtke-Wolenski, Ludwig Wilkens, Doris Steinemann, Stephan Singer, Felicitas Brass, Stefan Kubicka, Brigitte Schlegelberger, Peter Schirmacher, Michael P. Manns, Jeffrey D. Singer, Nisar P. Malek

Biology Faculty Publications and Presentations

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells. Upon induction of differentiation, Cul3-deficient progenitor cells underwent substantial DNA damage in vivo and in vitro, thereby triggering the activation of a cellular senescence response that selectively blocked the expansion of the differentiated offspring. Positive selection of undifferentiated progenitor cells required the expression of …

A City Club Report On Ballot Measure 26-108, City Club Of Portland (Portland, Or.)

City Club of Portland

No abstract provided.

Accurate Description Of The Optical Response Of A Multilayered Spherical System In The Long Wavelength Approximation, H. Y. Chung, G. Y. Guo, Hai-Pang Chiang, D. P. Tsai, P.T. Leung

Physics Faculty Publications and Presentations

The optical response of a multilayered spherical system of unlimited number of layers (a “matryoshka”) in the long wavelength limit can be accounted for from the knowledge of the static multipole polarizability of the system to first-order accuracy. However, for systems of ultrasmall dimensions or systems with sizes not-too-small compared to the wavelength, this ordinary quasistatic long wavelength approximation (LWA) becomes inaccurate. Here we introduce two significant modifications of the LWA for such a nanomatryoshka in each of the two limits: the nonlocal optical response for ultrasmall systems (<10 >nm), and the “finite-wavelength corrections” for systems ∼100 nm. This is …

How A Systems Engineer Starts..., Herman Migliore

Systems Science Friday Noon Seminar Series

Dr. Migliore will review systems engineering as a process for developing products, processes, and services and suggest views that encourage systems thinking. As an example, he will focus on the beginning of the development process, the fuzzy front end, and discuss a method, ConOps, for getting started using examples from PSU's masters program.

Legends At Work, Post-Katrina, Kate Parker

Harlot: A Revealing Look at the Arts of Persuasion

Sometimes what's lurking in the depths is scarier than an albino alligator. Supporting agency: The Surviving Katrina and Rita in Houston Project

Early Psychosis Intervention And Its Implications For Mental Health Counselors, Advocates And Supervisors: Lessons And Outcomes From The East Program, Ryan P. Melton

Regional Research Institute for Human Services

This presentation focuses on early psychosis intervention, identification, prevention, and intervention.

Teaching Matters: Developing As A Teacher/Librarian [Column]: Rules Of Engagement: Best Practices For Connecting With Students, Janelle M. Zauha

Communications in Information Literacy

This column focuses on the conceptual and practical aspects of teaching information literacy. Column co-editor Patrick Ragains and I write about trends and issues that have come to our attention, but we also solicit contributions to this space. Readers with ideas for Teaching Matters may contact Patrick Ragains at [email protected], or the editors of Communications in Information Literacy at [email protected].

Faculty Senate Monthly Packet October 2010, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The October 2010 Monthly packet includes the October agenda and appendices and the Faculty Senate minutes and attachments from the meeting held June 2010

Who's In Charge Here? Authority, Authoritativeness, And The Undergraduate Researcher, Marybeth Meszaros

Communications in Information Literacy

No abstract provided.

Unlearn What You Have Learned: Digital Disorganization And Information Literacy Instruction, Maryann Hight

Communications in Information Literacy

Traditional organizational schemes utilized for class design and for the organization of research materials means little to students comfortable with the disorganized internet environment. This article examines how constructivist principles and the disorganization of the internet was utilized to design a unique online information literacy course.