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Reduced Set-Shifting Processing Speed In Male Rats Following Low Dose (10 Cgy) Proton Exposure, Hui Ho Vanessa Chang, Gyutae Kim, Kyu-Sung Kim, Richard A. Britten Jan 2025

Reduced Set-Shifting Processing Speed In Male Rats Following Low Dose (10 Cgy) Proton Exposure, Hui Ho Vanessa Chang, Gyutae Kim, Kyu-Sung Kim, Richard A. Britten

Center for Integrative Neuroscience and Inflammatory Diseases (CINID) Faculty Publications

Space radiation (SR) exposure poses significant biomedical risks, including effects on the central nervous system (CNS). These risks are particularly relevant to cognitive function during long-duration space missions. One critical cognitive skill is decision-making, which requires attentional set-shifting (ATSET)—the ability to quickly assess problems, evaluate options, and select the best actions. Previous studies have shown that exposure to However, the impact of low LET (< 1 keV/μm) protons, which significantly contribute to the total radiation flux astronauts encounter within spacecraft, on ATSET performance is unknown. To address this gap, we evaluated the effects of cranial irradiation with 10 cGy of 100 MeV/n protons (LET = 0.732 keV/μm) on ATSET performance in male Sprague-Dawley rats. We also investigated whether concurrent exposure to variable gravity (hypergravity step-up, step down, purported to have the same effect as exposure to microgravity (another major spaceflight stressor) exacerbated SR-induced cognitive deficits. Our findings indicate that proton exposure alone significantly impaired ATSET performance, as evidenced by decreased processing speed while performing compound discrimination reversal and extra-dimensional shifting. Notably, no additive or synergistic effects were observed when hypergravity was combined with proton exposure. The impact that low-dose proton exposure has on CNS functionality, particularly in reducing processing speed during complex tasks, warrant further investigation. If similar cognitive deficits were to occur in astronauts exposed to galactic cosmic rays, mission success and safety could be significantly compromised.


Neuroinflammatory Signaling And Immune Cell Infiltration Differ In Brains Of Rats Exposed To Space Radiation And Social Isolation, Austin M. Adkins, Zachary N. M. Luyo, Alea F. Boden, Riley S. Heerbrandt, Richard A. Britten, Laurie L. Wellman, Larry D. Sanford Jan 2025

Neuroinflammatory Signaling And Immune Cell Infiltration Differ In Brains Of Rats Exposed To Space Radiation And Social Isolation, Austin M. Adkins, Zachary N. M. Luyo, Alea F. Boden, Riley S. Heerbrandt, Richard A. Britten, Laurie L. Wellman, Larry D. Sanford

Center for Integrative Neuroscience and Inflammatory Diseases (CINID) Faculty Publications

Astronauts on the proposed Mars missions will be exposed to extended periods of social isolation (SI) and space radiation (SR). SI and SR-induced immune dysregulation can result in persistent neuroinflammation and neuronal damage which could negatively impact an astronaut’s health and ability to maintain adequate levels of performance. The synergistic effects of combined SI and SR on immune system functionality and the brain remain unknown. Determining how single and combined inflight stressors modulate the immune system is crucial for fully understanding pathways impacting astronaut health and performance. We used ground-based analogs of SI and SR in rodent models to investigate …


Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar Jan 2025

Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

This study investigated a green chelation strategy for deashing algal biomass using nitrilotriacetic acid (NTA) and deionized water (DI) to enhance its suitability for biofuel and bioproduct applications. Solid-state algal turf scrubber (SS ATS), green algal turf scrubber (ATS), and Scenedesmus were analyzed, with Scenedesmus selected for detailed evaluation due to its high ash removal efficiency. The objective was to optimize a purification process that minimizes ash and heavy metal content while preserving biochemical integrity. Algal biomass underwent sequential washing with DI, NTA, and NTA+DI under varying temperatures (90-130 °C). Analytical techniques including Fourier Transform Infrared (FTIR) spectroscopy, Inductively Coupled …


Social Susceptibility-Driven Longitudinal Tornado Reconnaissance Methodology: 2021 Midwest Quad-State Tornado Outbreak, John W. Van De Lindt, Wanting "Lisa" Wang, Blythe Johnston, P. Shane Crawford, Guirong Yan, Thang Dao, Trung Do, Katie Skakel, Mojtaba Harati, Tu Nguyen, Robinson Umeike, Silvana Croope Jan 2025

Social Susceptibility-Driven Longitudinal Tornado Reconnaissance Methodology: 2021 Midwest Quad-State Tornado Outbreak, John W. Van De Lindt, Wanting "Lisa" Wang, Blythe Johnston, P. Shane Crawford, Guirong Yan, Thang Dao, Trung Do, Katie Skakel, Mojtaba Harati, Tu Nguyen, Robinson Umeike, Silvana Croope

Civil & Environmental Engineering Faculty Publications

With the impact of climate change, the intensity and frequency of tornado events have been increasing. Enhancing tornado reconnaissance methods can comprehensively capture building damage and recovery data following tornado events and outbreaks, thereby strengthening community resilience against the threat of future tornado events. Advancements in tornado data reconnaissance research have embraced remote sensing techniques to assess building damage after tornado events, supplanting traditional reconnaissance methods relying on handheld cameras with GIS mapping. Community resilience research offers a groundbreaking perspective, stressing the importance of assessing buildings throughout their recovery cycle-from damage and functionality to recovery-and considering their socioeconomic stability in …


Flexible Hybrid Self-Powered Piezo-Triboelectric Nanogenerator Based On Bto-Pvdf/Pdms Nanocomposites For Human Machine Interaction, Wentao Dong, Mengyun Li, Chang Chen, Kun Xie, Jinhua Hong, Lin Yang Jan 2025

Flexible Hybrid Self-Powered Piezo-Triboelectric Nanogenerator Based On Bto-Pvdf/Pdms Nanocomposites For Human Machine Interaction, Wentao Dong, Mengyun Li, Chang Chen, Kun Xie, Jinhua Hong, Lin Yang

Civil & Environmental Engineering Faculty Publications

As flexible and wearable electronics play more and more important role in smart watches, smart glass and virtual reality, and the power supply to the wearable electronics have been revealed more attentions for long-term usage and continuous healthy monitoring. To overcome the challenge, flexible self-powered BTO-PVDF/PDMS piezoelectric-triboelectric electric hybrid generators (BPP-HNG) are developed to human gesture monitoring and human machine interaction (HMI) application without external power supply. BPP-HNG based on BTO-PVDF and PDMS films are prepared by sol-gel and spin-coating method. When the BTO content is 20 wt.%, BPP-HNG exhibits better electrical performance with an output voltage of 20.51 V. …


Biochar For Soil Amendment: Applications, Benefits, And Environmental Impacts, Ujjwal Pokharel, Gururaj Neelgund, Ram L. Ray, Venkatesh Balan, Sandeep Kumar Jan 2025

Biochar For Soil Amendment: Applications, Benefits, And Environmental Impacts, Ujjwal Pokharel, Gururaj Neelgund, Ram L. Ray, Venkatesh Balan, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

The excessive use of chemical fertilizers results in environmental issues, including loss of soil fertility, eutrophication, increased soil acidity, alterations in soil characteristics, and disrupted plant–microbe symbiosis. Here, we synthesize recent studies available from up to 2025, focusing on engineered biochar and its application in addressing issues of soil nutrient imbalance, soil pollution from inorganic and organic pollutants, soil acidification, salinity, and greenhouse gas emissions from fields. Application of engineered biochar enhanced the removal of Cr (VI), Cd²+, Ni²+, Zn²+, Hg²+, and Eu³+ by 85%, 73%, 57.2%, 12.7%, 99.3%, and 99.2%, …


Tidal Flooding Contributes To Eutrophication: Constraining Nonpoint Source Inputs To An Urban Estuary Using A Data Driven Statistical Model, Alfonso Macías-Tapia, Margaret R. Mulholland, Corday R. Selden, Sophie Clayton, Peter W. Bernhardt, Thomas R. Allen Jan 2025

Tidal Flooding Contributes To Eutrophication: Constraining Nonpoint Source Inputs To An Urban Estuary Using A Data Driven Statistical Model, Alfonso Macías-Tapia, Margaret R. Mulholland, Corday R. Selden, Sophie Clayton, Peter W. Bernhardt, Thomas R. Allen

OES Faculty Publications

In coastal urban areas, tidal flooding brings water carrying nutrients and particles back from land to estuarine and coastal waters. A statistical model to predict nutrient loads during tidal flooding events can help estimate nutrient loading from previous and future flooding events and adapt nutrient reduction strategies. We measured concentrations of dissolved inorganic nitrogen and phosphorus in floodwater at seven sentinel sites during 15 tidal flooding events from January 2019 to September 2020. The study area was the Lafayette River watershed in Norfolk, VA, USA, which is prone to tidal flooding and is predicted to experience more frequent and intense …


Sandy Subterranean Estuaries Minimize Groundwater Nitrogen Pollution Impacts On Coastal Waters, Xiaogang Chen, Isaac R. Santos, Jinzhou Du, Bochao Xu, Joseph J. Tamborski, Ding He, Neven Cukrov, Christian J. Sanders, Jianan Liu, Peiyuan Zhu, Yan Zhang, Ling Li Jan 2025

Sandy Subterranean Estuaries Minimize Groundwater Nitrogen Pollution Impacts On Coastal Waters, Xiaogang Chen, Isaac R. Santos, Jinzhou Du, Bochao Xu, Joseph J. Tamborski, Ding He, Neven Cukrov, Christian J. Sanders, Jianan Liu, Peiyuan Zhu, Yan Zhang, Ling Li

OES Faculty Publications

Widespread anthropogenic activities pollute groundwater that eventually seeps out to the coastal ocean. Here, we resolve nutrient transformations and fluxes in 11 sandy subterranean estuaries (STEs) with contrasting nutrient sources and development trajectories. Coastal groundwater nitrogen pollution stems from sewage discharge and land use change. Anthropogenically derived groundwater nutrient fluxes with high N/P ratios (∼170) accounted for 22%–61% of riverine inputs into China's coastal waters, providing an additional source of nutrients that can fuel coastal eutrophication and algal blooms. Sandy STEs remarkably attenuated ∼84% of nitrogen pollution, minimizing the impact of submarine groundwater discharge (SGD) on coastal water quality. Hence, …


Seasonality Of Submarine Groundwater Discharge Pathways In A Coastal Lagoon Revealed By Radium Isotopes: The Importance Of Porewater Exchange In Summer, Júlia Rodriguez-Puig, Valentí Rodellas, Marc Diego-Feliu, Andres Alcolea, Joaquín Jiménez-Martínez, Irene Alorda-Montiel, Aaron Alorda-Kleinglass, Francisco Pereira, Marisol Manzano, Javier Gilabert, Jordi Garcia-Orellana Jan 2025

Seasonality Of Submarine Groundwater Discharge Pathways In A Coastal Lagoon Revealed By Radium Isotopes: The Importance Of Porewater Exchange In Summer, Júlia Rodriguez-Puig, Valentí Rodellas, Marc Diego-Feliu, Andres Alcolea, Joaquín Jiménez-Martínez, Irene Alorda-Montiel, Aaron Alorda-Kleinglass, Francisco Pereira, Marisol Manzano, Javier Gilabert, Jordi Garcia-Orellana

OES Faculty Publications

Chemical fluxes supplied by Submarine Groundwater Discharge (SGD) can be relevant for coastal ecosystems, particularly lagoonal environments. An appropriate understanding of SGD requires constraining the magnitude and composition of its different pathways. However, the evaluation of SGD pathways is often limited to independent estimations, lacking a comprehensive understanding of the groundwater processes at play. In this study, we combined a Ra mass balance and hydrogeological modeling to simultaneously estimate different SGD pathways flowing into a coastal lagoon. We assessed water fluxes derived from fresh SGD, long-scale recirculation of seawater, and porewater exchange (PEX) into Mar Menor, a highly anthropized coastal …


Ensemble Machine Learning Approaches For Bathymetry Estimation In Multi-Spectral Images, Kazi A. Islam, Omar Abdul-Hassan, Hongfang Zhang, Victoria Hill, Blake Schaeffer, Richard Zimmerman, Jiang Li Jan 2025

Ensemble Machine Learning Approaches For Bathymetry Estimation In Multi-Spectral Images, Kazi A. Islam, Omar Abdul-Hassan, Hongfang Zhang, Victoria Hill, Blake Schaeffer, Richard Zimmerman, Jiang Li

OES Faculty Publications

Traditional bathymetry measures require a large number of human hours, and many bathymetry records are obsolete or missing. Automated measures of bathymetry would reduce costs and increase accessibility for research and applications. In this paper, we optimized a recent machine learning model, named CatBoostOpt, to estimate bathymetry based on high-resolution WorldView-2 (WV-2) multi-spectral optical satellite images. CatBoostOpt was demonstrated across the Florida Big Bend coastline, where the model learned correlations between in situ sound Navigation and Ranging (Sonar) bathymetry measurements and the corresponding multi-spectral reflectance values in WV-2 images to map bathymetry. We evaluated three different feature transformations as inputs …


Optimizing An Image Analysis Protocol For Ocean Particles In Focused Shadowgraph Imaging Systems, Huanqing Huang, Alexander B. Bochdansky Jan 2025

Optimizing An Image Analysis Protocol For Ocean Particles In Focused Shadowgraph Imaging Systems, Huanqing Huang, Alexander B. Bochdansky

OES Faculty Publications

A variety of imaging systems are in use in oceanographic surveys, and the opto-mechanical configurations have become highly sophisticated. However, much less consideration has been given to the accurate reconstruction of imaging data. To improve reconstruction of particles captured by Focused Shadowgraph Imaging (FoSI)—a system that excels at visualizing low-optical-density objects, we developed a novel object detection algorithm to process images with a resolution of ~ 12 μm per pixel. Suggested improvements to conventional edge-detection methods are relatively simple and time-efficient, and more accurately render the sizes and shapes of small particles ranging from 24 to 500 μm. In addition, …


Dynamics Of Water Mass Exchange Across The Central Ross Sea Slope, Yuanjie Chen, Zhaoru Zhang, Pasquale Castagno, Xianxian Han, Michael S. Dinniman, Zhiqiang Liu, Chuning Wang Jan 2025

Dynamics Of Water Mass Exchange Across The Central Ross Sea Slope, Yuanjie Chen, Zhaoru Zhang, Pasquale Castagno, Xianxian Han, Michael S. Dinniman, Zhiqiang Liu, Chuning Wang

OES Faculty Publications

The central Ross Sea slope (CRSS) is a critical region for water mass exchange, significantly influencing the physical and biological processes of the Ross Sea shelf and the global overturning circulation. This study utilizes a high-resolution ocean-ice shelf-sea ice coupled model to investigate the mechanisms driving this exchange, involving the onshore transport of circumpolar deep water (CDW) and the offshore transport of dense shelf water (DSW). Combining numerical simulations and mooring observations, this work reveals high-frequency oscillations with a periodicity of ∼32 hr in CDW transport induced by Topographic Rossby Waves and DSW transport induced by cyclonic eddies. These findings …


A Century Of Sediment Metal Contamination Of Mar Menor, Europe's Largest Saltwater Lagoon, Irene Alorda-Montiel, Valentí Rodellas, Ariane Arias-Ortiz, Albert Palanques, Andrea G. Bravo, Júlia Rodriguez-Puig, Aaron Alorda-Kleinglass, Carlos Green-Ruiz, Marc Diego-Feliu, Pere Masqué, Javier Gilabert, Jordi Garcia-Orellana Jan 2025

A Century Of Sediment Metal Contamination Of Mar Menor, Europe's Largest Saltwater Lagoon, Irene Alorda-Montiel, Valentí Rodellas, Ariane Arias-Ortiz, Albert Palanques, Andrea G. Bravo, Júlia Rodriguez-Puig, Aaron Alorda-Kleinglass, Carlos Green-Ruiz, Marc Diego-Feliu, Pere Masqué, Javier Gilabert, Jordi Garcia-Orellana

OES Faculty Publications

Coastal enclosed ecosystems, such as lagoons, are vulnerable to anthropogenic impacts because they favor the accumulation of contaminants from the surrounding watersheds, particularly in their sediments. Europe's largest saltwater lagoon, the Mar Menor (SE, Iberian Peninsula), is a highly impacted ecosystem and the first in the continent to be granted personhood rights. Based on a high-resolution spatial and temporal dataset, we present the historical reconstruction of metal contamination in this ecosystem during the last century. Our results highlight that sediment metal contamination has been mainly driven by the development of the mining industry in the nearby Sierra Minera de Cartagena-La …


Successful Eastern Oyster (Crassostrea Virginica) Recruitment On Intertidal Artificial Substrates In Virginia, Usa, Rochelle D. Seitz, Kathleen E. Knick, Emily Suchonic, Amanda Pysher Jan 2025

Successful Eastern Oyster (Crassostrea Virginica) Recruitment On Intertidal Artificial Substrates In Virginia, Usa, Rochelle D. Seitz, Kathleen E. Knick, Emily Suchonic, Amanda Pysher

OES Faculty Publications

Declines of eastern oyster (Crassostrea virginica) populations and scarcity of natural oyster shell necessitate quantifying the effectiveness of artificial oyster reef substrates over varying environmental conditions. Oyster castles are often used in intertidal areas with moderate wave energy; however, new concrete, natural-looking substrates, GROW Reef Tiles, are now available. Eastern oyster recruitment and size on oyster castles (OC) and GROW Reef Tiles (GT), with 27% higher surface area on OC, were assessed three times over 25 months in locations with varying salinity. Four sites in the Chesapeake Bay region were examined: Cherrystone Inlet, Mockhorn Bay, Elizabeth River, and …


Unveiling Hidden Mercury And Methylmercury Sources: The Role Of Submarine Groundwater Discharge In Coastal Lagoons, Céline Lavergne, Júlia Rodriguez-Puig, Clara Ruiz-González, Maria Montero-Curiel, Gemma Casas, Daniel Romano-Gude, Irene Alorda-Montiel, Júlia Dordal-Soriano, Aaron Alorda-Kleinglass, Marc Diego-Feliu, Javier Gilabert, Alex Campillo-De La Maza, Cristina Romera-Castillo, Natalia Torres-Rodriguez, Lars-Eric Heimbürger-Boavida, Jordi Garcia-Orellana, Valenti Rodellas, Andrea G. Bravo Jan 2025

Unveiling Hidden Mercury And Methylmercury Sources: The Role Of Submarine Groundwater Discharge In Coastal Lagoons, Céline Lavergne, Júlia Rodriguez-Puig, Clara Ruiz-González, Maria Montero-Curiel, Gemma Casas, Daniel Romano-Gude, Irene Alorda-Montiel, Júlia Dordal-Soriano, Aaron Alorda-Kleinglass, Marc Diego-Feliu, Javier Gilabert, Alex Campillo-De La Maza, Cristina Romera-Castillo, Natalia Torres-Rodriguez, Lars-Eric Heimbürger-Boavida, Jordi Garcia-Orellana, Valenti Rodellas, Andrea G. Bravo

OES Faculty Publications

Mercury loads from Submarine Groundwater Discharge (SGD) may represent an overlooked source of methylmercury (MeHg) to the ocean, affecting human and ecosystem health. The SGD process involves the flow of fresh, saline, or mixed groundwater from coastal aquifers into the oceans classified in different components. Existing studies rarely report the fluxes supplied by the different SGD components; therefore, the relevance of SGD as a source of mercury remains unclear. We aimed to quantify SGD-driven mercury/methylmercury fluxes to the coast, focusing on the largest coastal lagoon in the western Mediterranean. We measured total dissolved mercury and MeHg in surficial and porewaters …


3d Bioprinting Technology Innovation In Female Reproductive System, Siyao Chen, Tongxin Wang, Jiaqi Chen, Mingxing Sui, Luyao Wang, Xueyu Zhao, Jianqiao Sun, Yingli Lu Jan 2025

3d Bioprinting Technology Innovation In Female Reproductive System, Siyao Chen, Tongxin Wang, Jiaqi Chen, Mingxing Sui, Luyao Wang, Xueyu Zhao, Jianqiao Sun, Yingli Lu

Department of Obstetrics & Gynecology Faculty Publications

Several diseases affect the female reproductive system, and both disease factors and treatments impact its integrity and function. Consequently, understanding the mechanisms of disease occurrence and exploring treatment methods are key research focuses in obstetrics and gynecology. However, constructing accurate disease models requires a microenvironment closely resembling the human body, and current animal models and 2D in vitro cell models fall short in this regard. Thus, innovative in vitro female reproductive system models are urgently needed. Additionally, female reproductive system diseases often cause tissue loss, yet effective tissue repair and regeneration have long been a bottleneck in the medical field. …


A Rare Complication Of Dilation And Evacuation: Unrecognized Extrauterine Retained Products Of Conception, Aviana Terschueren, Lauren Siewertsz Van Reesema, Joseph Hudgens Jan 2025

A Rare Complication Of Dilation And Evacuation: Unrecognized Extrauterine Retained Products Of Conception, Aviana Terschueren, Lauren Siewertsz Van Reesema, Joseph Hudgens

Department of Obstetrics & Gynecology Faculty Publications

Introduction: Surgical abortions, including dilation and evacuation, are among the safest gynecological procedures, with complication rates ranging from 0.5–4.0%. Uterine perforation, though rare (0.2–0.8%), can result in serious sequela, including translocation of retained products of conception into the abdominal cavity. We present a rare case of abdominal retained products of conception following a second-trimester dilation and evacuation.

Case Report: A 29-year-old G3P1112 underwent an elective surgical abortion at 17 weeks’ gestation, complicated by hemorrhage necessitating transfer to an outside hospital. She was treated with uterotonics and a blood transfusion and was discharged after a 6-day hospitalization. Initial transvaginal ultrasound showed …


Preliminary Validity Of A Daily Functional Status Pain Assessment Tool, Wally R. Smith, Rehan Qayyum, Alexandra Ulbing, Margaret S. Guy, Daniel M. Sop, Yue May Zhang Jan 2025

Preliminary Validity Of A Daily Functional Status Pain Assessment Tool, Wally R. Smith, Rehan Qayyum, Alexandra Ulbing, Margaret S. Guy, Daniel M. Sop, Yue May Zhang

Department of Medicine Faculty Publications

Objectives: Readiness for discharge for a sickle cell disease vaso-occlusive crisis is dictated by factors far beyond pain control, including physical function/activity. We therefore designed and tested a functional status-based pain assessment questionnaire in SCD patients hospitalized with vaso-occlusive crises.

Methods: Sickle cell disease patients on a preselected nursing unit rated 10 draft Functional status-Based Pain Assessment items of activities of daily living on a 5 point Likert scale (0-5) from “very easy” to “very difficult” daily on each day of their admission until discharge, at approximately the same time. Concurrently, they reported Numeric Rating Scale (0-10) pain intensity. …


Balancing Regeneration And Resistance: Targeting Dclk1 To Mitigate Gastrointestinal Radiation Injury And Oncogenesis, Landon L. Moore, Jerry Jaboin, Milton L. Brown, Courtney W. Houchen Jan 2025

Balancing Regeneration And Resistance: Targeting Dclk1 To Mitigate Gastrointestinal Radiation Injury And Oncogenesis, Landon L. Moore, Jerry Jaboin, Milton L. Brown, Courtney W. Houchen

Department of Medicine Faculty Publications

Ionizing radiation (IR) poses a dual challenge in medicine; while essential for cancer therapy, it inflicts collateral damage to normal tissues, particularly the gastrointestinal (GI) tract. High-dose IR triggers acute radiation syndrome (ARS), characterized by crypt stem cell depletion, mucosal barrier disruption, inflammation, and potential progression to fibrosis and secondary malignancy. Emerging evidence identifies the epithelial kinase doublecortin-like kinase 1 (DCLK1)—highly expressed in GI tuft cells and cancer stem-like cells—as a master regulator of post-IR responses. DCLK1 integrates DNA repair (via p53/ATM), and survival signaling (via NF-κB, TGF-β, and MAPK) to promote epithelial regeneration, yet these same mechanisms contribute to …


The Reliability Gap: How Traditional Search Engines Outperform Artificial Intelligence (Ai) Chatbots In Rosacea Public Health Information Quality, Houston C. Nelson, Morgan T. Beauchamp, April A. Pace Jan 2025

The Reliability Gap: How Traditional Search Engines Outperform Artificial Intelligence (Ai) Chatbots In Rosacea Public Health Information Quality, Houston C. Nelson, Morgan T. Beauchamp, April A. Pace

Department of Medicine Faculty Publications

Background: The internet has become a primary source of health information for the public, with important implications for patient decision-making and public health outcomes. However, the quality and readability of this content vary widely. With the rise of generative artificial intelligence (AI) tools such as ChatGPT and Gemini, new challenges and opportunities have emerged in how patients access and interpret medical information.

Objective: To evaluate and compare the quality, credibility, and readability of consumer health information provided by traditional search engines (Google, Bing) and generative AI platforms (ChatGPT, Gemini) using three validated instruments: DISCERN, JAMA Benchmark Criteria, and Flesch-Kincaid Readability …


Consumption Of The Food Groups With The Revised Benefits In The New Wic Food Package: A Scoping Review, Qi Zhang, Priyanka T. Patel, Bidusha Neupane, Caitlin M. Lowery, Futun Alkhalifah, Faezeh Mahdavi, Esther May Sarino Jan 2025

Consumption Of The Food Groups With The Revised Benefits In The New Wic Food Package: A Scoping Review, Qi Zhang, Priyanka T. Patel, Bidusha Neupane, Caitlin M. Lowery, Futun Alkhalifah, Faezeh Mahdavi, Esther May Sarino

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: On 18 April 2024, the United States Department of Agriculture (USDA) published the first food package changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in over a decade, which reduced some food benefits (juice, milk, canned fish, and infant fruits and vegetables) and offered substitutes (cash-value vouchers (CVVs) or cash-value benefits (CVBs) to redeem for fruits and vegetables, cheese, soymilk, or other dairy products). Methods: To assess the impact of the changes on the consumption and redemption of these food groups, a systematic search was conducted, identifying 23 peer-reviewed publications between 2010 and 2024. …


Pediatric Cancer Incidence, Temporal Trends, And Mortality In The United States By Health Disparities Indicators, Seer (1973-2014), Prachi P. Chavan, Laurens Holmes Jr. Jan 2025

Pediatric Cancer Incidence, Temporal Trends, And Mortality In The United States By Health Disparities Indicators, Seer (1973-2014), Prachi P. Chavan, Laurens Holmes Jr.

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: Pediatric cancer incidence has been increasing in the United States, despite improvement in pediatric cancer survival. This steady increase in incidence trends is not completely understood but maybe associated with social and environmental factors. In this study we aimed to assess the cumulative incidence, temporal trends, and mortality rates in pediatric cancer. Additionally, we examined sub-group variability in both incidence and mortality rates. Methods: Data from Surveillance, Epidemiology, and End Results (SEER) −18 from 1973–2014 were used for the purpose of analysis in this study. Age-adjusted incidence rates were used to assess temporal trends in cancer among children aged < 1–19 years. Univariable and multivariable binomial regression models were used to examine the association between race and cancer mortality while adjusting for potential confounders. Results: There were 92,594 cancer diagnoses during this period. White children comprised 74,758, (80.7%), black children 10,030, (10.8%), and other races 6648, (7.2%). Overall the age-adjusted cumulative incidence was slightly higher among white children (16.4%) than black children (12.4%) and other (13.0%). Children aged 15–19 years and those in metropolitan regions were more likely to be diagnosed with pediatric cancer. Relative to females, males were 16% more likely to die from the disease [adjusted Risk Ratio (aRR): 1.16, 95% Confidence Interval (CI): 1.09–1.22]. Additionally, compared to white children, black children had higher mortality rates [(aRR): 1.37, 99% CI: 1.23–1.52]. Conclusions: There is an increasing trend in pediatric cancer incidence; while white children have the highest incidence, black children and males indicated a survival disadvantage, indicative of racial and sex variability in overall pediatric cancer in the United States.


State Preparation Of Lattice Field Theories Using Quantum Optimal Control, Jack Y. Araz, Siddhanth Bhowmick, Matt Grau, Thomas J. Mcentire, Felix Ringer Jan 2025

State Preparation Of Lattice Field Theories Using Quantum Optimal Control, Jack Y. Araz, Siddhanth Bhowmick, Matt Grau, Thomas J. Mcentire, Felix Ringer

Physics Faculty Publications

We explore the application of quantum optimal control (QOC) techniques to state preparation of lattice field theories on quantum computers. As a first example, we focus on the Schwinger model, quantum electrodynamics in 1 + 1 dimensions. We demonstrate that QOC can significantly speed up the ground state preparation compared to gate-based methods, even for models with long-range interactions. Using classical simulations, we explore the dependence on the interqubit coupling strength and the device connectivity, and we study the optimization in the presence of noise. While our simulations indicate potential speedups, the results strongly depend on the device specifications. In …


Eic 197 Mhz Crab Cavity Hom Damping And Tolerence Analysis, Z. Li, B. Xiao, S. U. De Silva, Q. Wu, J. R. Delayen, R. Rimmer Jan 2025

Eic 197 Mhz Crab Cavity Hom Damping And Tolerence Analysis, Z. Li, B. Xiao, S. U. De Silva, Q. Wu, J. R. Delayen, R. Rimmer

Physics Faculty Publications

Crab cavities, operating at 197 MHz and 394 MHz respectively, will be used to compensate the loss of luminosity due to a 25 mrad crossing angle at the interaction point in the Electron Ion Collider (EIC). Both cavities are of the RF Dipole (RFD) type. To meet the stringent impedance requirements for beam stability and quality, the cavity design must incorporate strong Higher Order Mode (HOM) damping. A special type of HOM coupler has been developed (for both horizontal and vertical HOMs), which consisting of a waveguide stub that couples to the cavity and a waveguide-to-coaxial transition that extracts the …


Psychosocial Determinants Of Public Transportation Use Among Brazilian And American Users: An Integrated Modeling Approach, Ingrid Luiza Neto, Hartmut Günther, Bryan E. Porter, Taciano L. Milfont, Pastor Willy Gonzales Taco, Caroline Cardoso Machado Jan 2025

Psychosocial Determinants Of Public Transportation Use Among Brazilian And American Users: An Integrated Modeling Approach, Ingrid Luiza Neto, Hartmut Günther, Bryan E. Porter, Taciano L. Milfont, Pastor Willy Gonzales Taco, Caroline Cardoso Machado

Psychology Faculty Publications

Overreliance on cars can promote individual, environmental, economic and social problems, requiring the development of measures to reduce car use and encourage the use of more sustainable transport options. Contributing to this call, here we report a cross-cultural study conducted in Brazil (n = 312) and the United States (n = 518) investigating the applicability of the model of Bamberg and Möser in predicting the use of public transport. Results indicated the model is equivalent across samples, regarding both the measures and the relations between the variables of the model. Intention strongly predicted self-reported public transport behaviour, explaining 70% of …


A Bridge Too Low, John Adam Jan 2025

A Bridge Too Low, John Adam

Mathematics & Statistics Faculty Publications

The article "A bridge too low" in the Physics Teacher journal discusses a low bridge near the River Greta in Keswick, England, with an arch shaped like a semiellipse. It presents questions about the maximum height a person of a certain height can walk under the bridge without hitting their head, the cross-sectional area of the arch, its eccentricity, and perimeter. The article also mentions the approximation by Indian mathematician Srinivasa Ramanujan for the perimeter of an ellipse and invites readers to find the answers online.


The Motives For Mergers And Acquisitions And Their Implications For Research And Practice, Kris Irwin, Craig Armstrong, Paul Drnevich, Mario Schijven Jan 2025

The Motives For Mergers And Acquisitions And Their Implications For Research And Practice, Kris Irwin, Craig Armstrong, Paul Drnevich, Mario Schijven

Management Faculty Publications

Mergers and Acquisitions (M&A) have long intrigued scholars given their size, complexity, and frequent failure. Despite an extensive body of research on M&A, a key limitation in M&A research is the lack of focus on the motives underpinning acquisitions, which may explain frequent mixed and inconclusive results. Much of the existing literature struggles to fully capture the complex and multifaceted nature of these motives, limiting the ability to draw consistent conclusions. In this paper, we review academic and practical perspectives on M&A motives, highlighting both discrepancies and methodological challenges. Our key contributions include a comparison of theoretical and practical insights, …


Individual Entrepreneurial Orientation: Scale Development And Validation, Daniel R. Clark, Jeffrey G. Covin, Robert J. Pidduck Jan 2025

Individual Entrepreneurial Orientation: Scale Development And Validation, Daniel R. Clark, Jeffrey G. Covin, Robert J. Pidduck

Management Faculty Publications

Recent research introduced and laid the foundation for a new individual-level entrepreneurial orientation conceptualization (Ind.EO) within the entrepreneurial orientation family of constructs. Building directly from this work, this article theoretically defines a measurement model for the construct and develops and validates a scale. We define and measure disposition-based behavior constructs for autonomy, competitiveness, innovativeness, proactiveness, and risk-taking, thus providing psychometrically validated tools that support research in the burgeoning Ind.EO domain. Scale items are generated deductively from our definitions, and then tested through four data collections with academics, the lay population, entrepreneurs, and business managers. Strong validation data across these multiple …


Problem-Centered Post-Secondary Computer Science Education: A Study Of The Private Artificial Intelligence Curriculum, Golnoush Haddadian, Prajwal Panzade, Daniel Takabi, Min Kyu Kim Jan 2025

Problem-Centered Post-Secondary Computer Science Education: A Study Of The Private Artificial Intelligence Curriculum, Golnoush Haddadian, Prajwal Panzade, Daniel Takabi, Min Kyu Kim

School of Cybersecurity Faculty Publications

In response to the demand for Artificial Intelligence (AI) experts, this study introduced a curriculum development initiative. The aim was to design and implement a Private AI curriculum to understand the computer science (CS) students’ evaluations of the curricular activities and their levels of interest and motivation. Twenty-five students, a mix of undergraduates and graduates, were recruited and a scaled-down version of the curriculum was implemented. A parallel mixed-methods approach was employed. The results reinforced the significance of problem-centered curricula in CS context. Students rated the curricular activities highly and demonstrated strong motivation; however, graduates expressed more favorable view of …


Privacy-Preserved And Incentivized Knowledge Sharing For Reinforced-Learning Based Iot Platform Security, Weichao Wang, Md Morshed Alam, Yu Wang Jan 2025

Privacy-Preserved And Incentivized Knowledge Sharing For Reinforced-Learning Based Iot Platform Security, Weichao Wang, Md Morshed Alam, Yu Wang

School of Cybersecurity Faculty Publications

With the fast development and deep penetration of IoT devices and smart environments, using localized machine learning models to detect malicious activities has also been developed and deployed. However, these isolated learning models and results cannot be effectively federated together because of privacy concerns and lack of incentivization. This paper proposed several mechanisms to solve the problem. A verification method was designed for phased learning results to protect user privacy and prevent individual parties from manipulating the verification selection. The paper also presented an incentive method based on delay of distribution of the latest federated learning results. Extensive simulations were …