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Regional Pain Is Associated With Functional Performance In People With Parkinson's Disease, Ryan P. Duncan, Monica R. Hendricksen, Luke Ekdahl, Kevin Smaller, Benjamin Friedman, Miriam R. Rafferty Jan 2026

Regional Pain Is Associated With Functional Performance In People With Parkinson's Disease, Ryan P. Duncan, Monica R. Hendricksen, Luke Ekdahl, Kevin Smaller, Benjamin Friedman, Miriam R. Rafferty

Department of Medicine Faculty Publications

Background and Purpose:

Little is known about how pain influences physical function in people with mild Parkinson disease (PwPD). The purpose of this study was to investigate the association between physical function and pain presence, location, and intensity in PwPD who were evaluated in an early physical therapy program.

Methods:

Retrospective cross-sectional analysis of electronic medical records from patients with PD evaluated at a single center (2016-2023). Pain presence, location, and intensity (0-10 scale) were recorded at the initial physical therapy evaluation. Functional outcomes included 5-time sit-to-stand, 10-meter walk test, 6-minute walk test, timed up and go, mini-BESTest, and Functional …


Microplastics, Nanoplastics, And Obesity: Current Evidence And Biological Mechanisms, Maram Albandak, Sanam Rabeeah, Ahmad Mahdi Zahidi, David A. Johnson Jan 2026

Microplastics, Nanoplastics, And Obesity: Current Evidence And Biological Mechanisms, Maram Albandak, Sanam Rabeeah, Ahmad Mahdi Zahidi, David A. Johnson

Department of Medicine Faculty Publications

Obesity is a rapidly growing global health concern. The pathogenesis is complex and cannot be fully explained by lifestyle factors alone. The increasing attention towards this concern has finally been directed towards environmental contributors which may influence metabolic regulation. Microplastics and nano-plastics (MNPs) are ubiquitous environmental pollutants that have recently been detected in food, drinking water, air, and human biological samples, raising concerns about their potential role in metabolic disorders, including obesity. Chronic exposure to MNPs may interfere with metabolic homeostasis through multiple biological pathways. Emerging evidence, including both experimental and animal studies, reports alterations in lipid metabolism, body weight, …


Paneugenesis: A Regenerative Systems Hypothesis For Advancing Health Promotion, Craig M. Becker, Leslie Hoglund, Beth Chaney, Joseph G. L. Lee, Michael Stellefson, Alex Davis Jan 2026

Paneugenesis: A Regenerative Systems Hypothesis For Advancing Health Promotion, Craig M. Becker, Leslie Hoglund, Beth Chaney, Joseph G. L. Lee, Michael Stellefson, Alex Davis

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Despite major advances in health promotion science, dominant approaches remain largely prevention-and risk-reduction-oriented. The prevailing orientation creates a substantial opportunity to advance generative, system-design strategies that intentionally produce well-being rather than merely prevent disease. This article proposes paneugenesis as a regenerative systems framework and a testable theoretical model for the intentional creation of net-positive outcomes, thereby extending health promotion beyond its traditional pathogenic emphasis. Paneugenesis integrates systems science, salutogenesis, behavioral science, complexity theory, and quality management principles into a unified four-function process: operationalizing idealized outcomes, identifying key precursors, optimizing processes, and continually plotting progress through feedback mechanisms. The central hypothesis …


Dynamic Modeling Of The Earth's Trapped Proton Environment, Xiaojing Xu, Steve R. Blattnig, Francis F. Badavi, Martha S. Clowdsley, Edward J. Semones Jan 2026

Dynamic Modeling Of The Earth's Trapped Proton Environment, Xiaojing Xu, Steve R. Blattnig, Francis F. Badavi, Martha S. Clowdsley, Edward J. Semones

Physics Faculty Publications

Context: Reliable prediction of space radiation exposure is critical for safeguarding spacecraft systems and ensuring astronaut health during missions. Accurate radiation risk assessment for space mission requires advanced models of the Earth’s trapped proton environment. These models must reflect temporal variations driven by geomagnetic field evolution and solar cycle modulation. Existing static models, such as AP8 and IRENE-AP9, are not designed to fully capture these evolving conditions. Aims: This paper presents a dynamic modeling method for the prediction of trapped proton fluxes, which incorporate time-dependent variations due to geomagnetic field evolution and solar cycle fluctuations. Methods: The …


K-Long Facility At Jlab, Moskov Amaryan Jan 2026

K-Long Facility At Jlab, Moskov Amaryan

Physics Faculty Publications

In this talk I present the outline of K-long Facility (KLF) at JLab [1]. It was approved by PAC48 in 2020 to run for 200 days of beamtime, equally divided between liquid hydrogen and deuterium targets, to measure dozens of hyperon states predicted by CQM and LQCD but not yet established. This facility also will allow to measure Kπ scattering in different channels to observe the so-called ᴷ scalar meson and measure its width and position with unprecedented accuracy. Finally, it will be shown that exotic baryons can be measured at this facility in formation reactions with a two-body final …


Exploring Causes Of Beam Loss At Cebaf, C. Matthews, J. Benesch, R. M. Bodenstein, B. Freeman, D. Moser, D. Turner, K. Price, J. Samari, B. Terzić Jan 2026

Exploring Causes Of Beam Loss At Cebaf, C. Matthews, J. Benesch, R. M. Bodenstein, B. Freeman, D. Moser, D. Turner, K. Price, J. Samari, B. Terzić

Physics Faculty Publications

At Jefferson Lab, the Continuous Electron Beam Accelerator (CEBAF) features a unique design with two linear accelerators and two arc sections allowing for multiple turns of the electron beam, as well as four experimental end stations. This topology leads to increased beam losses, especially in the spreader and recombiner regions connecting the arcs to the LINACs and in the extraction regions connecting the experimental end stations to the accelerator. These losses result in equipment activation and operational interruptions. Recent upgrades to the facility’s diagnostic systems, including the addition of xenon ion chambers, have provided higher-resolution data regarding these loss events. …


Gaze Transition Entropy And Automation Trust In Multitasking Workspace, Yusuke Yamani, Austin Jackson, Tetsuya Sato, Feyishola Ashimi, Michael S. Politowicz, Eric T. Chancey, Makoto Itoh Jan 2026

Gaze Transition Entropy And Automation Trust In Multitasking Workspace, Yusuke Yamani, Austin Jackson, Tetsuya Sato, Feyishola Ashimi, Michael S. Politowicz, Eric T. Chancey, Makoto Itoh

Psychology Faculty Publications

Safe flight operation requires visual scanning across multiple displays in a cockpit, which collectively represent the state of the aircraft and supporting automation. Trust is a crucial factor that drives human-automation interaction, and recent work has suggested a relationship between an operator's visual attention and automation trust. One index that captures predictability of eye movements between different areas of interest is gaze transition entropy. The current work reanalyzed data from Sato et al., which examined eye movement patterns and trust in automation associated with the system monitoring task of the Multi-Attribute Task Battery. Results showed credible positive correlations between the …


Formulation Development Of Topical Inserts Containing Doxycycline And Doxycycline Combined With Tenofovir Alafenamide And Elvitegravir For The Prevention Of Sexually Transmitted Infections, Vivek Agrahari, M. Melissa Peet, Jasmin Monpara, Rijo John, Sriramakamal Jonnalagadda, Pardeep K. Gupta, Meredith R. Clark, Gustavo F. Doncel Jan 2026

Formulation Development Of Topical Inserts Containing Doxycycline And Doxycycline Combined With Tenofovir Alafenamide And Elvitegravir For The Prevention Of Sexually Transmitted Infections, Vivek Agrahari, M. Melissa Peet, Jasmin Monpara, Rijo John, Sriramakamal Jonnalagadda, Pardeep K. Gupta, Meredith R. Clark, Gustavo F. Doncel

CONRAD Publications

Despite advances in oral and injectable HIV prevention options and oral prophylaxis for sexually transmitted infections (STIs) of bacterial origin, there remains a critical need for effective on-demand topical (vaginal and rectal) products for pre- and post-exposure prophylaxis (PrEP and PEP). To fill this gap, we have developed single and first-in-kind multi-active topical inserts for bacterial STIs and HIV/STIs prevention. We have formulated two different inserts, one containing doxycycline (DOX) at 10, 50, and 100 mg doses for bacterial STI prevention, and a multipurpose prevention product (TED insert) that combines DOX (10 mg) with the antiretrovirals tenofovir alafenamide (TAF; 20 …


Drafting Policy To Address Academic Integrity: The Other Ai In Education, Elizabeth Burns Jan 2026

Drafting Policy To Address Academic Integrity: The Other Ai In Education, Elizabeth Burns

STEMPS Faculty Publications

The article focuses on the role of school librarians in drafting policies to address academic integrity amid the increasing use of artificial intelligence (AI) in K-12 education. It defines AI, including generative AI (GenAI), and discusses both the challenges and opportunities AI presents for teaching and learning, emphasizing the need for clear guidelines on ethical use. The article outlines three common AI policy models—permissive, hybrid, and restrictive—and stresses the importance of collaboration between librarians and teachers to establish consistent expectations, promote critical thinking, and ensure proper attribution of AI-generated content. School librarians are positioned as key facilitators in guiding students …


Large Language Model-Assisted Research Question Development In Public Health: A Case Study In The Special Supplemental Nutrition Program For Women, Infants, And Children (Wic), Qi Zhang, Bidusha Neupane, Priyanka Patel, Futun N. Alkhalifah, Yi He, Leslie Hodges Jan 2026

Large Language Model-Assisted Research Question Development In Public Health: A Case Study In The Special Supplemental Nutrition Program For Women, Infants, And Children (Wic), Qi Zhang, Bidusha Neupane, Priyanka Patel, Futun N. Alkhalifah, Yi He, Leslie Hodges

Health Behavior, Policy & Management Faculty Publications

Objective:

To assess the feasibility of using large language models (LLMs) to develop research questions about changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) food packages.

Design:

We conducted a controlled experiment using ChatGPT-4 and its plugin, MixerBox Scholarly, to generate research questions based on a section of the USDA summary of the final public comments on the WIC revision. Five questions weekly for three weeks were generated using LLMs under two conditions: fed with or without relevant literature. The experiment generated 90 questions, which were evaluated using the FINER criteria (Feasibility, Innovation, Novelty, Ethics, …


A Critical Perspective On The Society Of Environmental Toxicology And Chemistry's Adherence To Founding Principles— Opportunities For The Future, Barnett A. Rattner, Annegaaike Leopold, Carys L. Mitchelmore, Glenn W. Suter, Mark S. Johnson, Adriana C. Bejarano, Lawrence A. Kapustka, Niranjana Krishnan, Derek C. G. Muir, Beatrice O. Opeolu, Martha Georgina Orozco-Medina, April Reed, Bruce W. Vigon, Adam R. Wronski Jan 2026

A Critical Perspective On The Society Of Environmental Toxicology And Chemistry's Adherence To Founding Principles— Opportunities For The Future, Barnett A. Rattner, Annegaaike Leopold, Carys L. Mitchelmore, Glenn W. Suter, Mark S. Johnson, Adriana C. Bejarano, Lawrence A. Kapustka, Niranjana Krishnan, Derek C. G. Muir, Beatrice O. Opeolu, Martha Georgina Orozco-Medina, April Reed, Bruce W. Vigon, Adam R. Wronski

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

The Society of Environmental Toxicology and Chemistry (SETAC) is a global organization whose mission is the advancement of environmental science and management through collaboration, leadership, communication and education. On SETAC's 45th anniversary, the following question was raised: Are the 1979 founding principles of SETAC, multidisciplinary approaches to solving environmental problems, multisector engagement and scientific objectivity, still useful, adequate and effective in fulfilling its mission? In a special session held at the 45th Annual Meeting in Fort Worth, Texas, United States, a critical evaluation of the founding principles was initiated by reviewing SETAC's history and ongoing activities, and recommendations were made …


The Crucial Role Of Machine Learning Models In Predicting Current Childhood Asthma: Model Comparison, Calibration, And Shap-Based Interpretation, Aditya Chakraborty, A. K.M. Raquibul Bashar Jan 2026

The Crucial Role Of Machine Learning Models In Predicting Current Childhood Asthma: Model Comparison, Calibration, And Shap-Based Interpretation, Aditya Chakraborty, A. K.M. Raquibul Bashar

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: Asthma is one of the most prominent chronic diseases in children and one of the most challenging ailments to diagnose in infants and preschoolers in the United States. Predictive models can be instrumental in improving early diagnosis, personalized treatment strategies, and disease progression. By utilizing nationalized data, this study focuses on building and comparing high-performing analytical predictive models based on the relevant risk factors and identifying the most influential predictors.

Methods: We analyzed cross-sectional BRFSS Asthma Call-Back Survey data (2011-2020; N = 9,813) and randomly split participants into training and testing sets. An XGBoost model (hyperparameters tuned via grid …


Adaptive Multi-Grade Deep Learning For Highly Oscillatory Fredholm Integral Equations Of The Second Kind, Jie Jiang, Yuesheng Xu Jan 2026

Adaptive Multi-Grade Deep Learning For Highly Oscillatory Fredholm Integral Equations Of The Second Kind, Jie Jiang, Yuesheng Xu

Mathematics & Statistics Faculty Publications

This paper studies the use of Multi-Grade Deep Learning (MGDL) for solving highly oscillatory Fredholm integral equations of the second kind. We provide rigorous error analyses of continuous and discrete MGDL models, showing that the discrete model retains the convergence and stability of its continuous counterpart under sufficiently small quadrature error. We identify the DNN training error as the primary source of approximation error, motivating a novel adaptive MGDL algorithm that selects the network grade based on training performance. Numerical experiments with highly oscillatory (including wavenumber 500) and singular solutions confirm the accuracy, effectiveness and robustness of the proposed approach.


Changepoint Analyses Confirms Global Tropical Cyclone Frequency Decline, Michael Wehner, Thomas Fisher, Norou Diawara, Robert Lund Jan 2026

Changepoint Analyses Confirms Global Tropical Cyclone Frequency Decline, Michael Wehner, Thomas Fisher, Norou Diawara, Robert Lund

Mathematics & Statistics Faculty Publications

Changes in tropical cyclone frequencies as the climate warms is a topic of significant current debate [1, 2]. There is no accepted theory of how tropical cyclogenesis might respond to a warmer ocean-atmosphere system as multiple controlling factors exist [3–7]. Anthropogenic warming of surface ocean temperatures due to increased greenhouse gas concentrations [8] increases the potential for tropical cyclogenesis [9–11]; however, realized cyclogenesis also requires an initial local disturbance [12–16] to develop. Most multi-decadal tropical cyclone permitting climate models (i.e. resolutions of 15-50km) exhibit frequency decreases in warmer climates, despite the increase in tropical cyclogenesis potential [17–25]. In this paper, …


From Screens To Stress: Public Health Implications Of Cancer Worry In A Digitally Connected World, Shreya Mathur, Ethan Burns, Michael Pokojovy, Tzu-Liang Bill Tseng, Sunil Mathur Jan 2026

From Screens To Stress: Public Health Implications Of Cancer Worry In A Digitally Connected World, Shreya Mathur, Ethan Burns, Michael Pokojovy, Tzu-Liang Bill Tseng, Sunil Mathur

Mathematics & Statistics Faculty Publications

Aims:

This study examines how digital information environments, genetic testing experiences, health behaviors, and psychological distress influence cancer-related worry among adults in the United States. It further considers the public health implications of elevated or reduced cancer worry for prevention and risk communication.

Methods:

Data were drawn from a nationally representative survey of 6,252 U.S. adults. Measures included reliance on social media for health decision-making, smoking status, history of genetic testing, and psychological distress. Multivariable analyses assessed associations between these factors and levels of cancer worry.

Results/Findings:

Reliance on social media for health decisions was associated with greater cancer worry, …


A Composite Narxnn Approach To Photovoltaic Power Forecasting With Integrated Weather Inputs And Uncertainty Quantification, Denisse Urenda Castañeda, Sharmin Abdullah, Jackson Morgan, Honglun Xu, Michael Pokojovy, Tzu-Liang Tseng Jan 2026

A Composite Narxnn Approach To Photovoltaic Power Forecasting With Integrated Weather Inputs And Uncertainty Quantification, Denisse Urenda Castañeda, Sharmin Abdullah, Jackson Morgan, Honglun Xu, Michael Pokojovy, Tzu-Liang Tseng

Mathematics & Statistics Faculty Publications

Solar photovoltaics (PV) are a major source of sustainable energy. Yet, their power output is highly sensitive to environmental variability, particularly solar irradiance, cloud cover, wind, and temperature. Accurate forecasting of PV power is essential for efficient grid integration and energy planning, especially in applications requiring reliable longer-term forecasting rather than one-step-ahead predictions. This study presents a PV power forecasting approach using Nonlinear Autoregressive models with Exogenous Inputs (NARX), integrating large-scale numerical weather historical data as exogenous variables. Although NARX models effectively capture temporal dependencies, they can become overly dependent on historical power values, reducing responsiveness to real-time weather changes. …


Board Attributes, Firm Performance, And The Moderating Role Of National Culture: A Meta-Analysis, Matthew Farrell, Chris H. Willis, Nathapon Siangchokyoo, Ryan L. Klinger, Jamil Kreugel, Hami Usta, Timiry R. Tian, Ying Thaviphoke, Samuel Wilson Jan 2026

Board Attributes, Firm Performance, And The Moderating Role Of National Culture: A Meta-Analysis, Matthew Farrell, Chris H. Willis, Nathapon Siangchokyoo, Ryan L. Klinger, Jamil Kreugel, Hami Usta, Timiry R. Tian, Ying Thaviphoke, Samuel Wilson

Management Faculty Publications

Research Question/Issue

The impact of board structures on firm performance remains a contentious governance topic with competing theoretical paradigms and inconclusive empirical support. Scholars propose that national culture could reconcile contradictory evidence; yet, argumentation is fragmented and direct tests are rare. We meta‐analyzed 513 samples across 54 countries to examine relationships between board structures (i.e., board size, board independence, and CEO duality) and firm performance. We model national culture, using Hofstede's six cultural dimensions, as moderators to test whether these relationships align with agency or stewardship theory across different cultural settings.

Research findings/insights

Findings indicate a substantial moderating role of …


The Emerging Social Media Water Cooler? Motivations For Reddit Use In A Niche League, Jan Boehmer, Brendan O'Hallarn Jan 2026

The Emerging Social Media Water Cooler? Motivations For Reddit Use In A Niche League, Jan Boehmer, Brendan O'Hallarn

Communication & Theatre Arts Faculty Publications

Social media play a key role in sport marketing—with athletes, teams, and leagues directly engaging with their audiences. While Facebook, Instagram, and Twitter have received much attention in the sport marketing and communication literature, research on Reddit is scant. This is particularly noteworthy, as the platform is growing rapidly and promises utility for users with nonmainstream interests to find and engage with each other. This study employs a uses and gratifications approach to investigate how prevalent Reddit use is among fans of the United Football League (UFL), what motivates users to engage with the platform, and whether Reddit use leads …


Adaptive Boundary-Aware Fact-Checker Placement For Misinformation Suppression In Social Networks, Mostafa Taghizade Firouzjaee, Ghazal Naderi, Ross Gore, Neda Moghim Jan 2026

Adaptive Boundary-Aware Fact-Checker Placement For Misinformation Suppression In Social Networks, Mostafa Taghizade Firouzjaee, Ghazal Naderi, Ross Gore, Neda Moghim

School of Cybersecurity Faculty Publications

The spread of fake news on online social networks is driven by imitation-based user behavior and network topology, often leading to persistent misinformation clusters and echo chambers. In this study, we develop a spatial evolutionary game-theoretic framework in which agents update their latent opinions through payoff-biased imitation, while external fact-checkers act as non-imitative intervention nodes. Building on this formulation, we propose an adaptive, boundary-aware intervention mechanism that dynamically regulates both the density and spatial allocation of fact-checkers according to real-time system conditions. Competing information clusters are identified through local neighborhood composition, enabling boundary nodes, i.e., interfaces between fake-news and non-fake-news …


Toward Secure And Practical Machine Learning-Based Access Control: A Framework With Real-World Constraints And Adversarial Analysis, Olusesi Balogun, Mohammad Ghasemigol, Zhipeng Cai, Daniel Takabi Jan 2026

Toward Secure And Practical Machine Learning-Based Access Control: A Framework With Real-World Constraints And Adversarial Analysis, Olusesi Balogun, Mohammad Ghasemigol, Zhipeng Cai, Daniel Takabi

School of Cybersecurity Faculty Publications

Attribute-Based Access Control (ABAC) frameworks coordinate access requests based on subject, object, and environment attributes, as well as policy rules, and are widely used in corporate security systems. Recently, machine learning has been applied to ABAC to address policy-generation imbalances, misassigned privileges, and attribute leakages. However, existing MLBAC techniques do not consider the structural constraints and attribute interdependencies present in traditional ABAC systems. Moreover, these frameworks have not been extensively evaluated under black-box attack scenarios. To address these gaps, we propose extensions to MLBAC that integrate structural constraints, attribute dynamism, and attribute weighting into the MLBAC objective function. Additionally, we …


Cybersecurity Center For Offshore Wind Energy (Final Project Round), Sachin Shetty Jan 2026

Cybersecurity Center For Offshore Wind Energy (Final Project Round), Sachin Shetty

Center for Secure and Intelligent Critical Systems (CSICS) Publications

This project establishes a Cybersecurity Center for Offshore Wind Energy with the objective of designing and operating a cyber-physical testbed for wind energy farms (WEFs) that enables comprehensive cybersecurity research. The testbed incorporates a Supervisory Control and Data Acquisition (SCADA) system connected to turbine models via industrial-grade programmable logic controllers (PLCs) and remote terminal units (RTUs). It supports side-channel data acquisition, implementation and analysis of various cyberattack scenarios, and development of attack detection, mitigation, and best-practice guidance tailored to wind energy systems. During the project, the team expanded the number and fidelity of mathematical turbine models (MTMs), integrated these models …


Multisystem Predictors Of Dynamic Gait Stability Across Fall Risk In Older Adults, Ashwini Kulkarni, Neda Moghim, Ross Gore, Soumya Banerjee, Christopher K. Rhea, Brittany Samulski Jan 2026

Multisystem Predictors Of Dynamic Gait Stability Across Fall Risk In Older Adults, Ashwini Kulkarni, Neda Moghim, Ross Gore, Soumya Banerjee, Christopher K. Rhea, Brittany Samulski

Rehabilitation Sciences Faculty Publications

Gait stability arises from interactions between physiological, cognitive, and psychological systems, yet these domains are often assessed in isolation. This study examined multisystem predictors of anteroposterior margin of stability during walking (MoSAP) in community-dwelling older adults. Of 340 participants, 143 were retained after data quality screening (105 females; age: 70.8 ± 7.8 years). Participants completed the Physiological Profile Assessment (PPA), cognitive testing using Montreal Cognitive Assessment (MoCA), fear-of-falling evaluations using Modified Falls Efficacy Scale (MFES) and a biomechanical gait assessment during preferred and fast speeds. Participants were stratified into four PPA-based fall-risk groups: low, mild, moderate, and high risk. MoSAP …


The Fox Versus The Hedgehog: Firm Survival During Unprecedented Crises, Sheng Fang, Shaomin Li, Liu Wang Jan 2026

The Fox Versus The Hedgehog: Firm Survival During Unprecedented Crises, Sheng Fang, Shaomin Li, Liu Wang

Management Faculty Publications

This paper examines how sales channel diversification influences firm resilience during the COVID crisis. Drawing on a series of logit regressions analyzing 11,662 firms across 31 developing countries, we find that firms embodying an open mind-set and a diverse array of sales channels, akin to foxes, are more likely to survive, as compared to their hedgehog counterparts, which focus on one particular task. Our mediation analysis suggests that this is mainly due to their faster growth in sales and exports. Moreover, we find that the impact of fox-like traits on firm survival is moderated by female leadership and corporate innovation.


Chromnet: A Multi-Task Learning Framework For Cross-Cell Type Prediction Of 3d Chromatin Interactions Using Epigenetic Signals, Bin Wang, Shaokai Wang, Liqing Ding, Hongdong Li, Yaohang Li, Jianxin Wang Jan 2026

Chromnet: A Multi-Task Learning Framework For Cross-Cell Type Prediction Of 3d Chromatin Interactions Using Epigenetic Signals, Bin Wang, Shaokai Wang, Liqing Ding, Hongdong Li, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

The 3D organization of chromatin plays a fundamental role in gene regulation, cellular function, and disease mechanisms. However, current experimental techniques, such as Hi-C, remain costly and labor-intensive, limiting their application in large-scale and disease-related studies. To address this challenge, ChromNet is presented, a multi-task learning framework that integrates epigenetic signals across diverse cell types to enable high-precision prediction of chromatin architecture. By incorporating noise perturbation and auxiliary classification tasks, ChromNet improves the identification of topologically associating domains (TADs) and cell-type-specific chromatin structures, demonstrating superior generalization performance. Notably, ChromNet accurately predicts chromatin interactions in acute myeloid leukemia (AML) samples by …


A Comprehensive Overview Of Neurophysiological Correlates Of Cognitive Impairment In Amyotrophic Lateral Sclerosis, Seyyed Bahram Borgheai, Brie E. Achorn, Alyssa H. Zisk, Sarah M. Hosni, Karl E. G. Richter, Frank S. Menniti, Yalda Shahriari Jan 2026

A Comprehensive Overview Of Neurophysiological Correlates Of Cognitive Impairment In Amyotrophic Lateral Sclerosis, Seyyed Bahram Borgheai, Brie E. Achorn, Alyssa H. Zisk, Sarah M. Hosni, Karl E. G. Richter, Frank S. Menniti, Yalda Shahriari

Computer Science Faculty Publications

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the gradual loss of motor control, typically resulting in paralysis and death within 3 to 5 years of diagnosis. ALS shares neuropathological and genetic associations with fronto-temporal dementia (FTD), a neurodegenerative condition primarily impacting cognitive functions. These two conditions are increasingly viewed as manifestations of a single molecular disease process that affects distinct brain systems, impacting motor neuronal pathways in ALS and fronto-cortical functions in FTD. However, this simple dichotomy belies the complexity of these conditions. In particular, patients with primary motor ALS can also experience significant cognitive …


Cognitive Prosthetic: An Ai-Enabled Multimodal System For Episodic Recall In Knowledge Work, Lawrence Obiuwevwi, Krzystof J. Rechowicz, Vikas Ashok, Sachin Shetty, Sampath Jayarathna Jan 2026

Cognitive Prosthetic: An Ai-Enabled Multimodal System For Episodic Recall In Knowledge Work, Lawrence Obiuwevwi, Krzystof J. Rechowicz, Vikas Ashok, Sachin Shetty, Sampath Jayarathna

Computer Science Faculty Publications

Modern knowledge workplaces increasingly strain human episodic memory as individuals navigate fragmented attention, overlapping meetings, and multimodal information streams. Existing workplace tools provide partial support through note-taking or analytics but rarely integrate cognitive, physiological, and attentional context into retrievable memory representations. This paper presents the Cognitive Prosthetic Multimodal System (CPMS)—an AI-enabled proof-of-concept designed to support episodic recall in knowledge work through structured episodic capture and natural language retrieval. CPMS synchronizes speech transcripts, physiological signals, and gaze behavior into temporally aligned, JSON-based episodic records processed locally for privacy. Beyond data logging, the system includes a web-based retrieval interface that allows users …


Quantum Machine Learning Models: Principles, Frameworks, And Computational Challenges, K. A. Jayabalaji, S. Venkata Anand, Dineshkumar Rajendran, Prasanta Chatterjee Biswas, Sardor Omonov, Rubaid Ashfaq Jan 2026

Quantum Machine Learning Models: Principles, Frameworks, And Computational Challenges, K. A. Jayabalaji, S. Venkata Anand, Dineshkumar Rajendran, Prasanta Chatterjee Biswas, Sardor Omonov, Rubaid Ashfaq

Computer Science Faculty Publications

Quantum machine learning (QML) has become an optimistic avenue of harnessing quantum computation in data-driven modeling, especially of issues with high dimensionality and complicated correlations. Current methods are generally based on fixed or over-parameterized quantum circuits, and hence restricted to scalability as well as unproductive optimization in real-world hardware. This chapter introduces a hybrid quantum-classical learning system that is adaptive and provides principled quantum data encoding, architecture-conscious variational circuit design and resource-optimal optimization. The technique is based on the concepts of quantum architecture search and subspace-preserving transformations to trade expressiveness with trainability, and discretize the quantum model into a classical …


Examining Inclusive Computing Education For Blind Students In India, Akshay Kolgar Nayak, Yash Prakash, Md Javedul Ferdous, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok Jan 2026

Examining Inclusive Computing Education For Blind Students In India, Akshay Kolgar Nayak, Yash Prakash, Md Javedul Ferdous, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok

Computer Science Faculty Publications

The growing demand for computer professionals, driven by the expanding Information Technology industry, has led to numerous inclusive computing education efforts. These efforts have even included blind or visually-impaired (BVI) students, who are being increasingly encouraged to pursue education and a career in computing, despite the visually-oriented nature of the discipline. Extant literature has predominantly focused on identifying and addressing the accessibility barriers faced by BVI students to promote more inclusive learning environments. While few studies have also investigated the accessibility of computing education from the perspectives of BVI learners and instructors, these have been primarily situated in the Global …


The Privacy Paradox Of Llms: User Perceptions And The Reality Of Pii Leakage, Shuai Cheng, Haitao Xu, Shu Meng, Shuai Hao, Chuan Yue, Zhao Li Jan 2026

The Privacy Paradox Of Llms: User Perceptions And The Reality Of Pii Leakage, Shuai Cheng, Haitao Xu, Shu Meng, Shuai Hao, Chuan Yue, Zhao Li

Computer Science Faculty Publications

Large language models (LLMs) are increasingly deployed, yet they introduce significant privacy risks by disclosing personally identifiable information (PII) during interactions. Although prior work has demonstrated the feasibility of extracting PII from LLMs, no comprehensive study has evaluated the actual extent of PII leakage across mainstream LLMs or investigated user perceptions, literacy, and behavioral responses to these risks. To address these gaps, we conduct a large-scale evaluation of PII leakage in popular LLMs, demonstrating that attackers can extract email addresses and phone numbers with high success rates. Through a mixed-methods study involving 20 interviews and 204 survey participants, we identify …


An Explainable Transformer Framework For Sentiment Analysis In Aviation Workforce Data, Sovon Chakraborty, Protiva Das, Fahmid Al Farid, Fuyad Hasan Bhoyan, Farig Yousuf Sadeque, Jia Uddin, Hezerul Abdul Karim Jan 2026

An Explainable Transformer Framework For Sentiment Analysis In Aviation Workforce Data, Sovon Chakraborty, Protiva Das, Fahmid Al Farid, Fuyad Hasan Bhoyan, Farig Yousuf Sadeque, Jia Uddin, Hezerul Abdul Karim

Computer Science Faculty Publications

Aviation is one of the predominant sectors that contribute significantly to the global economy. With the advent of technology, this industry is witnessing a paradigm shift towards data-driven approaches. The morale of the airline employees is barely noticed, which causes fatigue and depression. Furthermore, these mental health issues can be active reasons for destructive accidents. In this research, the authors are focused on collecting insightful information on aviation employees from Glassdoor.com. Moreover, the authors focus on analyzing the sentiments of the employees of renowned aviation companies. Primarily, the authors scraped necessary data from Glassdoor.com and created a dataset named JetJobJoy …