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Articles 721 - 750 of 6144
Full-Text Articles in Entire DC Network
Submarine Groundwater Discharge As A Major Nutrient Source In River-Fed Vs. Tidally Dominated Estuaries, Stephanie J. Wilson, Joseph J. Tamborski, Bongkeun Song, Peter Bernhardt, Margaret R. Mulholland
Submarine Groundwater Discharge As A Major Nutrient Source In River-Fed Vs. Tidally Dominated Estuaries, Stephanie J. Wilson, Joseph J. Tamborski, Bongkeun Song, Peter Bernhardt, Margaret R. Mulholland
OES Faculty Publications
The tidal tributaries of the lower Chesapeake Bay experience seasonally recurring harmful algal blooms and the significance of submarine groundwater discharge (SGD) as a nutrient vector is largely unknown. Here, we determined seasonal SGD nutrient loads in two tributaries with contrasting hydrodynamic conditions, river-fed (York River) vs. tidally dominated (Lafayette River). Radon surveys were performed in each river to quantify SGD at the embayment-scale during spring and fall 2021. Total SGD was determined from a ²²²Rn mass balance and Monte Carlo simulations. Submarine groundwater discharge rates differed by a factor of two during spring (Lafayette = 11 ± 17 cm …
Parametric Study Of The Effect Of Increased Magnetic Field Exposure On Microalgae Chlorella Vulgaris Growth And Bioactive Compound Production, Sharanabasaweshwara Asundi, Sanurag Rout, Simone Stephen, Sanghamitra Khandual, Sandipan Dutta, Sandeep Kumar
Parametric Study Of The Effect Of Increased Magnetic Field Exposure On Microalgae Chlorella Vulgaris Growth And Bioactive Compound Production, Sharanabasaweshwara Asundi, Sanurag Rout, Simone Stephen, Sanghamitra Khandual, Sandipan Dutta, Sandeep Kumar
Mechanical & Aerospace Engineering Faculty Publications
This parametric study aimed to analyze the effects of increased magnetic field exposure (MFE) on the growth and production of the bioactive compounds of Chlorella (C.) vulgaris. With the intent of studying the effect of an increased MFE, the magnetic field typically experienced by life on Earth was amplified by an order of magnitude. In the increased-MFE environment, six treatments of C. vulgaris with two repetitions for each treatment were exposed to a magnetic field of 5 Gauss (500 µT) about each axis, which was generated in a state-of-the-art Helmholtz cage. The treatments and the control were characterized by the …
Kinodynamic Motion Planning For A System With Squid Dynamics, Logan E. Beaver, Cong Wei, Wei-Kuo Yen
Kinodynamic Motion Planning For A System With Squid Dynamics, Logan E. Beaver, Cong Wei, Wei-Kuo Yen
Mechanical & Aerospace Engineering Faculty Publications
This paper introduces a path planning algorithm for a system with squid dynamics in a cluttered environment. We capture the complex interactions of fin, arms, and body patterning by analyzing experimental data collected from observing squid motion. We extract nine motion primitives to build the control sequence for a time-optimal trajectory. This task is formulated as a mixed-integer program, and we generate the minimum-time trajectory using a sample-based approach. Numerical simulations illustrate the efficacy of this strategy and motivate ongoing and future efforts to exploration of squid motion features, improvement of the modeling, and experimental demonstrations of the motion planning …
Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper
Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper
Chemistry & Biochemistry Faculty Publications
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent quantitative analysis of small molecules. While evaporatively prepared samples yield significant SERS enhancement resulting in lower detection limits, the distribution of these enhancements along the SERS surface is inherently stochastic. Acquiring spatially resolved SERS spectra of these dried surfaces, we have shown that this enhancement is governed by a power law as a function of analyte concentration. Consequently, by definition, …
Exploration Of Potential Broad-Spectrum Antiviral Targets In The Enterovirus Replication Element: Identification Of Six Distinct 5' Cloverleaves, Morgan G. Daniels, Meagan E. Werner, Rockwell T. Li, Steven M. Pascal
Exploration Of Potential Broad-Spectrum Antiviral Targets In The Enterovirus Replication Element: Identification Of Six Distinct 5' Cloverleaves, Morgan G. Daniels, Meagan E. Werner, Rockwell T. Li, Steven M. Pascal
Chemistry & Biochemistry Faculty Publications
Enterovirus genomic replication initiates at a predicted RNA cloverleaf (5′CL) at the 5′ end of the RNA genome. The 5′CL contains one stem (SA) and three stem-loops (SLB, SLC, SLD). Here, we present an analysis of 5′CL conservation and divergence for 209 human health-related serotypes from the enterovirus genus, including enterovirus and rhinovirus species. Phylogenetic analysis indicates six distinct 5′CL serotypes that only partially correlate with the species definition. Additional findings include that 5′CL sequence conservation is higher between the EV species than between the RV species, the 5′CL of EVA and EVB are nearly identical, and RVC has the …
Reiq-Mediated Alarmone Signalling Regulates Growth, Stress-Induced Biofilm Formation And Spore Accumulation In Clostridioides Difficile, Areej Malik, Adenrele Oludiran, Asia Poudel, Orlando Berumen Alvarez, Charles Woodward, Erin B. Purcell
Reiq-Mediated Alarmone Signalling Regulates Growth, Stress-Induced Biofilm Formation And Spore Accumulation In Clostridioides Difficile, Areej Malik, Adenrele Oludiran, Asia Poudel, Orlando Berumen Alvarez, Charles Woodward, Erin B. Purcell
Chemistry & Biochemistry Faculty Publications
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, highly recurrent C. difficile infections. The role of the SR in other processes and the effectors by which it regulates C. difficile physiology are unknown. C. difficile RelQ is a clostridial alarmone synthetase. Deletion of relQ dysregulates C. difficile growth in unstressed conditions, affects susceptibility to antibiotic and oxidative stressors and drastically reduces biofilm formation. While wild-type C. difficile displays increased biofilm …
Multiple Variables Influence The Finely Calibrated Antioxidant Defenses Of Clostridioides Difficile, Erin B. Purcell
Multiple Variables Influence The Finely Calibrated Antioxidant Defenses Of Clostridioides Difficile, Erin B. Purcell
Chemistry & Biochemistry Faculty Publications
The obligate anaerobe Clostridioides difficile encodes multiple reductases to detoxify molecular oxygen and reactive oxygen species. Caulat and colleagues have characterized the activity and regulation of four such reductases (L. C. Caulat, A. Lotoux, M. C. Martins, N. Kint, et al., mBio 15:e01591-24, 2024, https://doi.org/10.1128/mbio.01591-24). Each proved critical for clostridial survival in a different range of oxygen concentrations; together, they ameliorate a broad range of oxidative stress levels. Moreover, two previously uncharacterized regulators were found to control reductase gene expression in response to oxidative stress. The genetic repressor Rex and the reductase FdpF are both sensitive to the NAP …
Antenatal Depression And Its Associated Factors: Findings From Kuwait Birth Cohort Study, Reem Al-Sabah, Abdullah Al-Taiar, Ali H. Ziyab, Saeed Akhtar, Majeda S. Hammoud
Antenatal Depression And Its Associated Factors: Findings From Kuwait Birth Cohort Study, Reem Al-Sabah, Abdullah Al-Taiar, Ali H. Ziyab, Saeed Akhtar, Majeda S. Hammoud
Community & Environmental Health Faculty Publications
Background: Pregnant and postpartum women are at high risk of depression due to hormonal and biological changes. Antenatal depression is understudied compared to postpartum depression and its predictors remain highly controversial.
Aim: To estimate the prevalence of depressive symptoms during pregnancy and investigate factors associated with this condition including vitamin D, folate and Vitamin B12 among participants in the Kuwait Birth Study.
Methods: Data collection occurred as part of the Kuwait Birth Cohort Study in which pregnant women were recruited in the second and third trimester during antenatal care visits. Data on antenatal depression were collected using the Edinburgh …
Electrophysiological And Clinical Fundamentals Of Qtc Prolongation Induced By Antipsychotic Medications, Zaid Naseer, Minaal Khan, Najeeb Manalai, Allison Foroobar, Patricia Harrison, Charles Scercy, Beth Yanoff, Partam Manalai
Electrophysiological And Clinical Fundamentals Of Qtc Prolongation Induced By Antipsychotic Medications, Zaid Naseer, Minaal Khan, Najeeb Manalai, Allison Foroobar, Patricia Harrison, Charles Scercy, Beth Yanoff, Partam Manalai
Department Surgery Faculty Publications
Patients with psychiatric disorders undergoing antipsychotic treatment are at an elevated risk for adverse cardiovascular events, including arrhythmias and sudden cardiac death. While the precise mechanisms linking cardiovascular diseases and psychiatric conditions remain unclear, QTc prolongation is suspected to be a contributing factor. The human ether-à-go-go-related gene (hERG, or KCNH2), which affects potassium channels, is implicated in the cardiotoxicity of various medications, including antipsychotics. This gene plays a critical role in determining whether a drug will be approved for market use. This paper elucidates the electrophysiological basis of QTc prolongation and reviews the evidence concerning which antipsychotics may exacerbate QTc …
Dynamics Of Cell Membrane Lesions And Adaptive Conductance Under The Electrical Stress, Mantas Silkunas, Olga N. Pakhomova, Giedre Silkuniene, Andrei G. Pakhomov
Dynamics Of Cell Membrane Lesions And Adaptive Conductance Under The Electrical Stress, Mantas Silkunas, Olga N. Pakhomova, Giedre Silkuniene, Andrei G. Pakhomov
Bioelectrics Publications
Exceeding physiological limits of the cell membrane potential compromises structural integrity, enabling the passage of normally impermeant solutes and disrupting cell function. Electropermeabilization has been studied extensively at the cellular scale, but not at the individual membrane lesion level. We employed fast total internal reflection fluorescence (TIRF) imaging of Ca(2+) entry transients to discern individual lesions in a hyperpolarized cell membrane and characterize their focality, thresholds, electrical conductance, and the lifecycle. A diffuse and momentary membrane permeabilization without a distinct pore formation was observed already at a -100 mV threshold. Polarizing down to -200 mV created focal pores with a …
Associations Between Urine Specific Gravity And Race/Ethnicity At The Population Level: Implications For Hydration Status Categorization, Ian P. Winter, Brain K. Ferguson, Patrick B. Wilson
Associations Between Urine Specific Gravity And Race/Ethnicity At The Population Level: Implications For Hydration Status Categorization, Ian P. Winter, Brain K. Ferguson, Patrick B. Wilson
Exercise Science Faculty Publications
Objective
We aimed to evaluate how urine specific gravity (USG) and rates of supposed hypohydration vary by race/ethnicity, and to examine how adjustment for several important factors impacts estimated USG.
Methods
Using the National Health and Nutrition Examination Survey, this cross‐sectional study evaluated a total of 4195 (2098 female, 2097 male) Americans and categorized them as supposedly hypohydrated (USG≥1.020) or not using spot urine samples. USG and prevalence of supposed hypohydration were compared across racial/ethnic groups, separately by gender. The analyses considered the impact of urine creatinine, body composition, age, dietary nutrients, and physical activity.
Results
Differences in supposed hypohydration …
Factors Affecting Electrocoagulation Process For Different Water Types: A Review, Shahad Fadhil Abed Al-Rubaye, Naseer A. Alhaboubi, Aiman H. Al-Allaq
Factors Affecting Electrocoagulation Process For Different Water Types: A Review, Shahad Fadhil Abed Al-Rubaye, Naseer A. Alhaboubi, Aiman H. Al-Allaq
Mechanical & Aerospace Engineering Faculty Publications
Raw water must meet specific physical, chemical, and biological requirements to be suitable for drinking. There are various techniques available for treating wastewater, and aside from conventional methods that involve chemicals, electrocoagulation is an efficient and advanced approach. Electrocoagulation has proven effective in treating many pollutants, including bacteria, viruses, iron, fluoride, sulfate, boron, hardness, and turbidity. Total suspended solids, organic and inorganic materials, chemical oxygen demand COD, biochemical oxygen demand BOD, and color. It finds extensive application in treating different types of water and wastewater due to its exceptional ability to remove diverse contaminants. Recently, electrocoagulation has garnered significant attention …
Integrative Machine Learning Approaches For Enhanced Classification Of Genomic Sequences: A Next-Generation Sequencing Perspective, Sujatha Alla, Nagesh Bheesetty, Sai Gireesh Komaragiri, Prasanthi Chidipudi, Joshit Mohanty, Sathish Kumar Chintala, Jubin Thomas, Jayapal Vummadi, Hemanth Volikatla, Navin Kamuni
Integrative Machine Learning Approaches For Enhanced Classification Of Genomic Sequences: A Next-Generation Sequencing Perspective, Sujatha Alla, Nagesh Bheesetty, Sai Gireesh Komaragiri, Prasanthi Chidipudi, Joshit Mohanty, Sathish Kumar Chintala, Jubin Thomas, Jayapal Vummadi, Hemanth Volikatla, Navin Kamuni
Engineering Management & Systems Engineering Faculty Publications
The advent of Next-Generation Sequencing (NGS) techniques has revolutionized genomic research by enabling the rapid sequencing of DNA and RNA. This data can be used for various applications, including genome sequencing, transcriptome profiling, metagenomics, and epigenetics studies. For this study, DNA classifier dataset was extracted from UCI repository of machine learning databases. This vast amount of genomic data necessitates the development of sophisticated machine learning (ML) models for effective classification and analysis. This study presents a comprehensive comparison of various ML models, including Support Vector Machines (SVM), Random Forests (RF), and Neural Networks (NNs), approaches, in classifying genomic data. We …
Ethically Informed Design, Brett Cook-Snell
Ethically Informed Design, Brett Cook-Snell
Educational Leadership & Workforce Development Faculty Publications
This design case presents my experiences, successes, and challenges, in the design and delivery of a six-week special topics course on culturally inclusive instructional design. The course was delivered synchronously with a diverse group of 15 individuals enrolled in the instructional design and technology degree program. The focus of the course was uncovering implicit and explicit biases in design practices. Topics addressed included the systemic isms of society, such as racism, ableism, genderism, and many more. Relevant to this special issue, ethical design practices are viewed in the light of the Association for Educational Communications and Technology (AECT) standards and …
Multifaceted Challenges And Opportunities: Concurrent Mixed Methods Research To Investigate Chinese Exchange Students' Experiences In The Us Transnational Online Learning Ecology, Xinyue Ren, Yi Zhou
Multifaceted Challenges And Opportunities: Concurrent Mixed Methods Research To Investigate Chinese Exchange Students' Experiences In The Us Transnational Online Learning Ecology, Xinyue Ren, Yi Zhou
STEMPS Faculty Publications
Transnational online education has become an emerging trend in promoting academic collaboration and exchange in higher education during and after the pandemic. Guided by the learning ecology framework, we conducted concurrent mixed methods research by distributing an online survey to Chinese students (N=51) to collect quantitative and qualitative data. This helped us deeply understand their experiences and perceptions of a cross-cultural online learning environment in the United States. We applied multiple regression and thematic analysis to analyze the data. The merging of both types of data analysis indicated the confirmation of the importance of discipline-based English learning environments, the transformation …
Urban Nature Indexes Tool Offers Comprehensive And Flexible Approach To Monitoring Urban Ecological Performance, Jennifer Rae Pierce, Laura Costadone, Lelani Mannetti, Joeri Morpurgo, Charlyn Elaine Green, Michael D. Halder, Pablo Arturo Lopez Guijosa, Abner L. Bogan, Russell Galt, Jonathan Hughes
Urban Nature Indexes Tool Offers Comprehensive And Flexible Approach To Monitoring Urban Ecological Performance, Jennifer Rae Pierce, Laura Costadone, Lelani Mannetti, Joeri Morpurgo, Charlyn Elaine Green, Michael D. Halder, Pablo Arturo Lopez Guijosa, Abner L. Bogan, Russell Galt, Jonathan Hughes
ODU Articles
We present the Urban Nature Indexes (UNI), a comprehensive tool that measures urban ecological performance under one standard framework linked to global commitments. The UNI was developed by interdisciplinary experts and evaluated by practitioners from diverse cities to capture each city’s ecological footprint from local to global scale. The UNI comprises six themes (consumption drivers, human pressures, habitat status, species status, nature’s contributions to people, and governance responses) that encompass measurable impacts on climate change, biodiversity loss, ecosystem services, pollution, consumption, water management, and equity within one comprehensive system. Cities then adapt the UNI to their context and capacity by …
Western Boundary Current-Subtropical Continental Shelf Interactions, William B. Savidge, Dana K. Savidge, Frederico Brandini, Adam T. Greer, Eileen E. Hofmann, Moninya Roughan, Iison De Silvera, Iain M. Suthers
Western Boundary Current-Subtropical Continental Shelf Interactions, William B. Savidge, Dana K. Savidge, Frederico Brandini, Adam T. Greer, Eileen E. Hofmann, Moninya Roughan, Iison De Silvera, Iain M. Suthers
CCPO Publications
Western boundary currents (WBCs) adjacent to subtropical continental shelves (STCSs; between ~25° and 35° latitude; Figure 1) transport heat, nutrients, and biota poleward along the western margins of major ocean basins, interacting with the continental margins and influencing their physics and biology. Eddies and meanders along the shelf edge upwell deep, nutrient-laden water that can be advected onto the adjacent shelves with a corresponding export of particle-rich shelf water (e.g., Lee et al., 1991; Kimura et al., 1997; Campos et al., 2000; Roughan and Middleton, 2002, 2004; Lutjeharms, 2006; Savidge and Savidge, 2014). Despite their similarities, the various STCS regions …
Building A Coordinated Framework For Research And Monitoring In Large-Scale International Marine Protected Areas: The Ross Sea Region As A Model System, Cassandra Brooks, Sharon Stammerjohn, Grant Ballard, Alice K. Duvivier, Eileen Hofmann, Michelle Larue, Cara Nissen, Alexander J. Orona, B. Jack Pan, Annie E. Schmidt, Nathan Walker, George M. Watters, John Weller
Building A Coordinated Framework For Research And Monitoring In Large-Scale International Marine Protected Areas: The Ross Sea Region As A Model System, Cassandra Brooks, Sharon Stammerjohn, Grant Ballard, Alice K. Duvivier, Eileen Hofmann, Michelle Larue, Cara Nissen, Alexander J. Orona, B. Jack Pan, Annie E. Schmidt, Nathan Walker, George M. Watters, John Weller
CCPO Publications
To fulfill their conservation potential and provide safeguards for biodiversity, marine protected areas (MPAs) need coordinated research and monitoring for informed management through effective evaluation of ecosystem dynamics. However, coordination is challenging, often due to knowledge gaps caused by inadequate access to data and resources, compounded by insufficient communication between scientists and managers. We propose to use the world's largest MPA in the Ross Sea, Antarctica as a model system to create a comprehensive framework for an interdisciplinary network supporting research and monitoring that could be implemented in other remote large-scale international MPAs. Our proposed framework has three key components: …
Pices At 32: An External Review, Eileen E. Hofmann, David Checkley, Fangli Qiao, Jörn Schmidt, Sinjae Yoo
Pices At 32: An External Review, Eileen E. Hofmann, David Checkley, Fangli Qiao, Jörn Schmidt, Sinjae Yoo
CCPO Publications
[Introduction] The North Pacific Marine Science Organization (Pacific ICES, PICES) has been an effective voice and proponent for North Pacific marine science for more than 30 years. During this time, PICES has provided a safe and active venue for the open exchange of science, developed an international science network that includes participants from academic and government institutions, and non- and inter-governmental organizations, and has taken on leadership roles in studying North Pacific ecosystems.
Radiation Induced Skin Fibrosis (Risf): Opportunity For Angiotensin Ii-Dependent Intervention, Patricia F. Boothe, Vidya P. Kumar, Yali Kong, Kan Wang, Howard Levinson, David Mu, Milton L. Brown
Radiation Induced Skin Fibrosis (Risf): Opportunity For Angiotensin Ii-Dependent Intervention, Patricia F. Boothe, Vidya P. Kumar, Yali Kong, Kan Wang, Howard Levinson, David Mu, Milton L. Brown
Department of Biomedical and Translational Sciences Faculty Publications
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a complex condition that poses substantial physical and psychological challenges. Notably, about 50% of patients undergoing radiation therapy may achieve long-term remission, resulting in a significant number of survivors managing the aftereffects of their treatment. This article delves into the intricate relationship between RISF, reactive oxygen species (ROS), and angiotensin II (Ang II) signaling. It proposes the underlying mechanisms and examines potential treatments for mitigating skin fibrosis. …
Gene Expression Of Tight Junctions In Foreskin Is Not Affected By Hiv Pre-Exposure Prophylaxis, Emily L. Webb, Stefan Petkov, Heejin Yun, Laura Else, Limakatso Lebina, Jennifer Serwanga, Azure-Dee A.P. Pillay, Thabiso B. Seiphetlo, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch, Daniel Opoka, Andrew S. Ssemata, Pontiano Kaleebu, Saye Khoo, Neil Martinson, Julie Fox, Clive M. Gray, Carolina Herrera, Francesca Chiodi
Gene Expression Of Tight Junctions In Foreskin Is Not Affected By Hiv Pre-Exposure Prophylaxis, Emily L. Webb, Stefan Petkov, Heejin Yun, Laura Else, Limakatso Lebina, Jennifer Serwanga, Azure-Dee A.P. Pillay, Thabiso B. Seiphetlo, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch, Daniel Opoka, Andrew S. Ssemata, Pontiano Kaleebu, Saye Khoo, Neil Martinson, Julie Fox, Clive M. Gray, Carolina Herrera, Francesca Chiodi
Department of Obstetrics & Gynecology Faculty Publications
Introduction: Tight junctions (TJs) serve as permeability filters between the internal and external cellular environment. A large number of proteins have been identified to be localized at the TJs. Due to limitations in tissue collection, TJs in the male genital tract have been understudied.
Methods: We analysed the transcriptomics of 132 TJ genes in foreskin tissue of men requesting voluntary medical male circumcision (VMMC) and enrolled in the Combined HIV Adolescent Prevention Study (CHAPS) trial conducted in South Africa and Uganda (NCT03986970). The trial evaluated the dose requirements for event-driven HIV pre-exposure prophylaxis (PrEP) with emtricitabine-tenofovir (FTC-TDF) or emtricitabine-tenofovir alafenamide …
Advancing Environmental Engineering: The Role Of Artificial Intelligence In Sustainable Solutions - A Short Review, Amirreza Talaie, Hesam Kamyab, Ashkan Razmfarsa
Advancing Environmental Engineering: The Role Of Artificial Intelligence In Sustainable Solutions - A Short Review, Amirreza Talaie, Hesam Kamyab, Ashkan Razmfarsa
Management Faculty Publications
Artificial intelligence (AI) has emerged as a transformative force in environmental engineering, offering innovative solutions to complex environmental challenges. From air pollution monitoring and water resource management to waste management, climate change mitigation, and ecological preservation, AI is revolutionizing the way we address environmental issues. Machine learning, neural networks, and other AI technologies are enabling more accurate predictions, optimizing resource use, and improving conservation efforts. However, despite its many advantages, AI also faces challenges such as data availability, energy consumption, ethical concerns, and the need for transparency. This review explores the diverse applications of AI in environmental engineering, highlighting the …
Predicting Radiation-Induced Immune Suppression In Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy, Jonathan Colen, Cam Nguyen, Seth W. Liyanage, Eric Aliotta, Joe Chen, Clayton Alonso, Kara Romano, Sean Peach, Timothy Showalter, Paul Read, James Larner, Krishni Wijesooriya
Predicting Radiation-Induced Immune Suppression In Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy, Jonathan Colen, Cam Nguyen, Seth W. Liyanage, Eric Aliotta, Joe Chen, Clayton Alonso, Kara Romano, Sean Peach, Timothy Showalter, Paul Read, James Larner, Krishni Wijesooriya
Data Science Faculty Publications
BACKGROUND: Stereotactic body radiation therapy (SBRT) is known to modulate the immune system and contribute to the generation of anti-tumor T cells and stimulate T cell infiltration into tumors. Radiation-induced immune suppression (RIIS) is a side effect of radiation therapy that can decrease immunological function by killing naive T cells as well as SBRT-induced newly created effector T cells, suppressing the immune response to tumors and increasing susceptibility to infections.
PURPOSE: RIIS varies substantially among patients and it is currently unclear what drives this variability. Models that can accurately predict RIIS in near real time based on treatment plan characteristics …
Season Influences Interspecific Responses Of Canopy-Forming Kelps To Future Warming And Acidification At High Latitude, Lauren E. Bell, Lily Westphal, Evan O' Brien, Jason A. Toy, Haleigh Damron, Kristy J. Kroeker
Season Influences Interspecific Responses Of Canopy-Forming Kelps To Future Warming And Acidification At High Latitude, Lauren E. Bell, Lily Westphal, Evan O' Brien, Jason A. Toy, Haleigh Damron, Kristy J. Kroeker
Biological Sciences Faculty Publications
Variability in primary producers' responses to environmental change may buffer higher trophic levels against shifts in basal resource composition. Then again, in instances where there is a lack of functional redundancy because consumers rely on a few species to meet their energetic requirements at specific times of the year, altered community production dynamics may significantly impact food web resilience. In high-latitude kelp forests, a complementary annual phenology of seaweed production supports coastal marine consumers' metabolic needs across large seasonal variations in their environment. Yet, marine consumers in these systems may face significant metabolic stress under the pronounced low pH conditions …
Targeting Ocean Conservation Outcomes Through Threat Reduction, Joseph A. Turner, Malcolm Starkey, Nicholas K. Dulvy, Frank Hawkins, Louise Mair, Adeline Serckx, Thomas Brooks, Beth Polidoro, Stuart H. M. Butchart, Kent Carpenter, Minna Epps, Rima W. Jabado, Nicholas B. W. Macfarlane, Leon Bennun
Targeting Ocean Conservation Outcomes Through Threat Reduction, Joseph A. Turner, Malcolm Starkey, Nicholas K. Dulvy, Frank Hawkins, Louise Mair, Adeline Serckx, Thomas Brooks, Beth Polidoro, Stuart H. M. Butchart, Kent Carpenter, Minna Epps, Rima W. Jabado, Nicholas B. W. Macfarlane, Leon Bennun
Biological Sciences Faculty Publications
Nations have committed to reductions in the global rate of species extinctions through the Sustainable Development Goals 14 and 15, for ocean and terrestrial species, respectively. Biodiversity loss is worsening despite rapid growth in the number and extent of protected areas, both at sea and on land. Resolving this requires targeting the locations and actions that will deliver positive conservation outcomes for biodiversity. The Species Threat Abatement and Restoration (STAR) metric, developed by a consortium of experts, quantifies the contributions that abating threats and restoring habitats in specific places offer towards reducing extinction risk based on the IUCN Red List …
A Taxonomic Revision Of The Genus Hydnora (Hydnoraceae), Sebastian A. Hatt, Chris J. Thorogood, J. F. Bolin, Lytton J. Musselman, Duncan D. Cameron, Olwen M. Grace
A Taxonomic Revision Of The Genus Hydnora (Hydnoraceae), Sebastian A. Hatt, Chris J. Thorogood, J. F. Bolin, Lytton J. Musselman, Duncan D. Cameron, Olwen M. Grace
Biological Sciences Faculty Publications
A systematic monograph is presented for Hydnora (Hydnoraceae), a poorly known genus of holoparasitic plants distributed across Africa, Madagascar and southern Arabia. Species of Hydnora are characterised by their underground habit, unusual fleshy flowers and complete absence of leaves or photosynthetic tissue. This is the first detailed monograph of the genus Hydnora since 1935 and is informed by a comprehensive survey of herbarium specimens and literature. Detailed descriptions, full synonymy, distribution maps and discussion concerning confusable taxa are provided for each species, along with notes on ethnobotany, ecology and conservation. We place particular emphasis on the taxonomic value of osmophore …
When And Where Can Coastal Wetland Restoration Increase Carbon Sequestration As A Natural Climate Solution, Scott F. Jones, Ariane Arias-Ortiz, Dennis Baldocchi, Meagan Eagle, Daniel A. Friess, Catrina Gore, Greg Noe, Stefanie Nolte, Patty Oikawa, Adina Paytan, Jacqueline L. Raw, Brian J. Roberts, Kerrylee Rogers, Charles Schutte, Camille L. Stagg, Karen M. Thorne, Eric J. Ward, Lisamarie Windham-Myers, Erik S. Yando
When And Where Can Coastal Wetland Restoration Increase Carbon Sequestration As A Natural Climate Solution, Scott F. Jones, Ariane Arias-Ortiz, Dennis Baldocchi, Meagan Eagle, Daniel A. Friess, Catrina Gore, Greg Noe, Stefanie Nolte, Patty Oikawa, Adina Paytan, Jacqueline L. Raw, Brian J. Roberts, Kerrylee Rogers, Charles Schutte, Camille L. Stagg, Karen M. Thorne, Eric J. Ward, Lisamarie Windham-Myers, Erik S. Yando
Biological Sciences Faculty Publications
Coastal wetlands are hotspots of carbon sequestration, and their conservation and restoration can help to mitigate climate change. However, there remains uncertainty on when and where coastal wetland restoration can most effectively act as natural climate solutions (NCS). Here, we synthesize current understanding to illustrate the requirements for coastal wetland restoration to benefit climate, and discuss potential paths forward that address key uncertainties impeding implementation. To be effective as NCS, coastal wetland restoration projects will accrue climate cooling benefits that would not occur without management action (additionality), will be implementable (feasibility) and will persist over management-relevant timeframes (permanence). Several issues …
Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth
Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth
Biological Sciences Faculty Publications
Globally, climate change is causing shifts in precipitation patterns. Shifting precipitation patterns can be a stressor for many species. One species that is experiencing such stress is Helenium amarum Raf (H. Rock). H. amarum, thrives in dry upland pastures and low-lying grassy and sandy habitat in the mid-Atlantic (USA), where it persists despite storm-driven standing water. Helenium amarum is a species that is toxic to livestock and has been found outside its native range. Temperature and light impacts on germination are already known, but the role of water availability and potential ameliorating effects of mycorrhizae during water stress have …
Abalones At Risk: A Global Red List Assessment Of Haliotis In A Changing Climate, Howard Peters, Gina M. Ralph, Laura Rogers-Bennett
Abalones At Risk: A Global Red List Assessment Of Haliotis In A Changing Climate, Howard Peters, Gina M. Ralph, Laura Rogers-Bennett
Biological Sciences Faculty Publications
There is increasing awareness that marine invertebrates such as abalones are at risk from the combined stressors of fishing and climate change. Abalones are an important marine fishery resource and of cultural importance to Indigenous and non-Indigenous people. A highly priced marine delicacy, they are inherently vulnerable: individuals are slow-growing and long-lived and successful reproduction requires dense assemblages. However, their global conservation status is poorly understood. Using IUCN Red List methodology, we assessed the extinction risk to all 54 species of abalone (genus Haliotis). Of the 21 fished commercially for human consumption either now and/or in the past, 15 …
Enhancing Rural Science Education Through School District-University Partnership, Venicia A. Ferrell, Alexis S. Tharpe
Enhancing Rural Science Education Through School District-University Partnership, Venicia A. Ferrell, Alexis S. Tharpe
Center for Educational Partnerships Publications
This instrumental case study describes the steps taken to establish and implement a university–school partnership to improve rural science teachers’ content knowledge and teaching practices and students’ achievement in elementary science and high school biology courses. Our research questions explored the impact of professional development and place-based learning on student outcomes, with the study’s methodology involving needs assessments, teacher training, and continuous support through modeling and coaching. The findings include gains in achievement and substantial gains in science education. The findings have implications for the design, implementation, and evaluation of university–school partnerships designed to build teachers’ capacity to deliver high-quality …