Digital Commons Network^™

Fem Media Matters: An Inqueery Into Campus Sexual Assault, Andrew Kennedy Garber

Graduate Program in International Studies Theses & Dissertations

Queer victimization as a topic is often marginalized within research due to hegemonic ideologies within society. When it comes to campus sexual assault research and resources, the focus is primarily on female victimization constructed within a heteronormative framework. Little research and theorization has been done on male victimization or the specificities of LGBTQ victimization of campus sexual assault. The problem this research has identified is that the female-victim-male-perpetrator metanarrative of campus sexual assault portrayed through media exemplifies the heterosexist culture at various levels of analysis within the United States. Further, it has led to an invisibility of LGBT and male …

Differential Gene Expression In Response To Hypoxia And Acidosis In Chest Wall Deformities And Chondrosarcoma, Jamie L. Durbin

Biological Sciences Theses & Dissertations

The importance of understanding how costal cartilage chondrocytes respond to stimuli such as oxidative stress and low pH has been largely overlooked in studies involving tissue culturing due to major differences between oxygen and pH levels during incubation and the natural environment of hyaline cartilage. Hyaline cartilage is avascular and naturally hypoxic which subsequently leads to increased glycolytic metabolism and ultimately causes a decrease in extracellular pH. To examine how healthy costal cartilage responds to these extreme growth conditions, we examined responses in three hyaline cartilage diseases. Our ability to identify the disease mechanisms responsible for pectus excavatum, pectus carinatum, …

Program: Graduate Research Achievement Day 2018, Graduate School, Old Dominion University

Graduate Research Achievement Day 2017-2018: Programs

Full program for 2018 Graduate Research Achievement Day.

F. Ludwig Diehn Chorale Premieres: A Day In The Life Of A Fifth Grader By Richard Moriority, Old Dominion University F. Ludwig Diehn Chorale, Nancy K. Klein (Director), Richard Moriarty (Composer), Elizabeth Hankin (Lyrics), Bobbie Kesler-Corleto, Emily Hines

Ensemble Performances

No abstract provided.

Graduate News, Graduate School, Old Dominion University

Graduate News

March 2018 issue of Graduate News from the ODU Graduate School.

Gas Plasma Pre-Treatment Increases Antibiotic Sensitivity And Persister Eradication In Methicillin-Resistant Staphylococcus Aureus, Li Guo, Ruobing Xu, Yiming Zhao, Dingxin Liu, Zhijie Liu, Xiaohua Wang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of serious nosocomial infections, and recurrent MRSA infections primarily result from the survival of persister cells after antibiotic treatment. Gas plasma, a novel source of ROS (reactive oxygen species) and RNS (reactive nitrogen species) generation, not only inactivates pathogenic microbes but also restore the sensitivity of MRSA to antibiotics. This study further found that sublethal treatment of MRSA with both plasma and plasma-activated saline increased the antibiotic sensitivity and promoted the eradication of persister cells by tetracycline, gentamycin, clindamycin, chloramphenicol, ciprofloxacin, rifampicin, and vancomycin. The short-lived ROS and RNS generated by plasma …

Carbon Budget Of Tidal Wetlands, Estuaries, And Shelf Waters Of Eastern North America, R. G. Najjar, M. Herrmann, R. Alexander, D. J. Burdige, D. Butman, W.-J. Cai, E. A. Canuel, R. F. Chen, M. A. M. Friedrichs, M. R. Mulholland

OES Faculty Publications

Carbon cycling in the coastal zone affects global carbon budgets and is critical for understanding the urgent issues of hypoxia, acidification, and tidal wetland loss. However, there are no regional carbon budgets spanning the three main ecosystems in coastal waters: tidal wetlands, estuaries, and shelf waters. Here we construct such a budget for eastern North America using historical data, empirical models, remote sensing algorithms, and process‐based models. Considering the net fluxes of total carbon at the domain boundaries, 59 ± 12% (± 2 standard errors) of the carbon entering is from rivers and 41 ± 12% is from the atmosphere, …

Comparison Of A Simplified Cupric Oxide Oxidation Hplc Method With The Traditional Gc-Ms Method For Characterization Of Lignin Phenolics In Environmental Samples (Vol 13, Pg 1, 2015), Luni Sun, Robert G. M. Spencer, Peter J. Hernes, Rachael Y. Dyda, Kenneth Mopper

Chemistry & Biochemistry Faculty Publications

In our article entitled “Comparison of a simplified cupric oxide oxidation HPLC method with the traditional GC-MS method for characterization of lignin phenolics in environmental samples” (Limnol. Oceanogr.: Methods 13, 2015, 1–52), doi: 10.1002/lom3.10001, we would like to correct the errors in Fig. 2 and Table 2 as mentioned below. The label to Fig. 2(a) needs to be transposed as indicated in the corrected Fig. 2 image below.

Density Estimation Of Spatio-Temporal Point Patterns Using Moran’S Statistics, Jennifer L. Lorio, Norou Diawara, Lance A. Waller

Mathematics & Statistics Faculty Publications

Moran’s Index is a statistic that measures spatial autocorrelation, quantifying the degree of dispersion (or spread) of objects in space. When investigating data in an area, a single Moran statistic may not give a sufficient summary of the autocorrelation spread. However, by partitioning the area and taking the Moran statistic of each subarea, we discover patterns of the local neighbors not otherwise apparent. In this paper, we consider the model of the spread of an infectious disease, incorporate time factor, and simulate a multilevel Poisson process where the dependence among the levels is captured by the rate of increase of …

Hampton Roads Residents’ Preferences For Dune And Beach Management, Seth Parker, Donta Council, Makayla Brown

School of Public Service Faculty Publications

The management of dunes and beaches in Hampton Roads is critical to the region’s tourism industry and to provide protection from storms and flooding. During the summer of 2017, we surveyed over 675 residents of Hampton Roads to gauge their preferences for the management of dunes and beaches. An overwhelming majority felt that all taxpayers should have a say in maintenance practices along with government regulations to assist with the protection of beaches and dunes. Residents leaned towards localized input from citizens as preferred methods of management and understood the importance their tax dollars play in funding those methods. While …

Digging Out The Devils: Molecular Examination Of Amoeba-Like Cells From Cranial Tissue Of The Endangered Rio Grande Silvery Minnow, Brandon Hamel

Undergraduate Research Symposium

The Rio Grande Silvery Minnow (Hybognathus amarus) is a critically endangered species native to the southwestern United States. Since the 1990s its population has declined dramatically due to extensive human alteration of the Rio Grande for agriculture and civil development. This has resulted in habitat degradation and impedance to proper migration, resulting in the minnow now occupying only 5% of its historical range. An active restocking and recovery program is underway through the US Fish and Wildlife Service involving breeding programs at three New Mexico sites. In the summer of 2012, aquaculture specimens began exhibiting an unusual spinning …

Inactivation Of Myeloma Cancer Cells By Helium And Argon Plasma Jets: The Effect Comparison And The Key Reactive Species, Zeyu Chen, Qingjie Cui, Chen Chen, Dehui Xu, Dingxin Liu, H. L. Chen, Michael G. Kong

Bioelectrics Publications

In plasma cancer therapy, the inactivation of cancer cells under plasma treatment is closely related to the reactive oxygen and nitrogen species (RONS) induced by plasmas. Quantitative study on the plasma-induced RONS that related to cancer cells apoptosis is critical for advancing the research of plasma cancer therapy. In this paper, the effects of several reactive species on the inactivation of LP-1 myeloma cancer cells are comparatively studied with variable working gas composition, surrounding gas composition, and discharge power. The results show that helium plasma jet has a higher cell inactivation efficiency than argon plasma jet under the same discharge …

New Approaches To Model Simulated Spatio-Temporal Moran's Index, Nhan Bu, Jennifer Lorio, Norou Diawara, Kumar Das, Lance Waller

Mathematics & Statistics Faculty Publications

The Moran's index is a statistic that measures spatial autocorrelation; it quantifies the degree of dispersion (or clustering) of objects in space. However, when investigating data over a general area, a single global Moran statistic may not give a sufficient summary of the spread, behavior, features or latent surfaces shared by neighboring areas; rather, by partitioning the area and taking the Moran statistic of each divided subareas, we can discover patterns of the local neighbors not otherwise apparent. In this paper, we present a simulation experiment where the local Moran values are computed and a time variable is added to …

Use Of An Optical Scanning Device To Monitor The Progress Of Noninvasive Treatments For Chest Wall Deformity: A Pilot Study, Robert E. Kelly Jr., Robert J. Obermeyer, Ann Kuhn, Frazier W. Frantz, Mohammad F. Obeid, Nahom Kidane, Frederic D. Mckenzie

Computational Modeling & Simulation Engineering Faculty Publications

Background: The nonsurgical treatment of chest wall deformity by a vacuum bell or external brace is gradual, with correction taking place over months. Monitoring the progress of nonsurgical treatment of chest wall deformity has relied on the ancient methods of measuring the depth of the excavatum and the protrusion of the carinatum. Patients, who are often adolescent, may become discouraged and abandon treatment. Methods: Optical scanning was utilized before and after the intervention to assess the effectiveness of treatment. The device measured the change in chest shape at each visit. In this pilot study, patients were included if they were …

Gender Disparities In The Association Between Socio-Demographics And Non-Communicable Disease Risk Factors Among Adults With Disabilities In Shanghai, China, Youran Zhang, Gang Chen, Qi Zhang, Jun Lu, Huijiong Yu

Community & Environmental Health Faculty Publications

BACKGROUND. Non-communicable disease (NCD) risk factors can co-exist with disability and cause a greater burden on the health status of adults with disabilities. A lack of egalitarian social policies in China may result in gender disparities in the NCD risk factors of adults with disabilities. However, little is known about the gender disparities in the association between socio-demographics and NCD risk factors among adults with disabilities in China; consequently, we examined this association among adults with disabilities in Shanghai, China.

METHODS. We used the health examination data of 44,896 adults with disabilities in Shanghai in 2014. Descriptive analyses and …

Advances In Processing, Mining, And Learning Complex Data: From Foundations To Real-World Applications, Jia Wu, Shirui Pan, Chuan Zhou, Gang Li, Wu He, Chengqi Zhang

Information Technology & Decision Sciences Faculty Publications

Processing, mining, and learning complex data refer to an advanced study area of data mining and knowledge discovery concerning the development and analysis of approaches for discovering patterns and learning models from data with a complex structure (e.g., multirelational data, XML data, text data, image data, time series, sequences, graphs, streaming data, and trees) [1–5]. These kinds of data are commonly encountered in many social, economic, scientific, and engineering applications. Complex data pose new challenges for current research in data mining and knowledge discovery as they require new methods for processing, mining, and learning them. Traditional …

A Proposed Taxonomy For The Systems Statistical Engineering Body Of Knowledge, Teddy Steven Cotter

Engineering Management & Systems Engineering Faculty Publications

In the ASEM-IAC 2012, Cotter (2012) identified the gaps in knowledge that statistical engineering needs to address, explored additional gaps in knowledge not addressed in the prior works, and set forth a working definition of and body of knowledge for statistical engineering. In the ASEM-IAC 2015, Cotter (2015) proposed a systemic causal Bayesian hierarchical model that addressed the knowledge gap needed to integrate deterministic mathematical engineering causal models within a stochastic framework. Missing, however, is the framework for specifying the hierarchical qualitative systems structures necessary and sufficient for specifying systemic causal Bayesian hierarchical models. In the ASEM-IAC 2016, Cotter (2016) …

Pathology-Informed Approach In Vulnerability Assessment Methods, Polinpapilinho F. Katina, Adrian V. Gheorghe, Charles B. Keating

Engineering Management & Systems Engineering Faculty Publications

A system pathology is a circumstance, condition, or pattern that acts to limit system performance, or lessen system viability, such that the likelihood of a system achieving performance expectation is reduced. The idea of pathology has been described in multiple fields, including computer science, organizational studies, policy analysis, system-of-systems engineering, and systems engineering. However, there is scarcity of literature describing relationship between system pathology and vulnerability assessment. The aim of this study lies at the intersection of system pathology and vulnerability assessment in engineered systems. First, authors provide the state of the art review of literature on system pathology. Second, …

A Method For Identification, Representation, And Assessment Of Complex System Pathologies In Acquisition Programs, Charles B. Keating, Polinpapilinho F. Katina, Keith F. Joiner, Joseph M. Bradley, Raed M. Jaradat

Engineering Management & Systems Engineering Faculty Publications

Acquisition programs continue to struggle with increasing complexity. High degrees of emergence, interconnectedness, and uncertainty are the norm rather than exception. The purpose of this research is to explore extension of ongoing research in complex system pathologies for acquisition programs. Significant advances have been made in development of deeper understanding of the nature of pathologies (deviations from healthy system function) and their implications for performance of complex systems. Complex system pathologies represent violations of underlying system principles. These violations negatively affect system governance functions (control, oversight, accountability) resulting in degradation of system performance. Greater understanding of complex system pathologies offers …

Technology And Discrimination, D. E. Wittkower

Philosophy Faculty Publications

This chapter develops a full theory of discriminatory technologies grounded in Heideggerian, Latourian, and Ihdean theoretical structures and demonstrates its applicability to a wide and widening range of forms of normativity, exclusion, and discrimination, taking place across intersections of race, ethnicity, gender, sexual orientation, trans/cisgender identity, disability, and religious identity. Technologies, technical systems, and artifacts considered are wide-ranging, and include algorithms, adhesive bandages, human resource management policies, calendars, VR systems, carpentry, strollers, photographic film formulation and printing, video game character classes, and stairs.

Asymmetric Patterns Of Small Molecule Transport After Nanosecond And Microsecond Electropermeabilization, Esin B. Sözer, C. Florencia Pocetti, P. Thomas Vernier

Bioelectrics Publications

Imaging of fluorescent small molecule transport into electropermeabilized cells reveals polarized patterns of entry, which must reflect in some way the mechanisms of the migration of these molecules across the compromised membrane barrier. In some reports, transport occurs primarily across the areas of the membrane nearest the positive electrode (anode), but in others cathode-facing entry dominates. Here we compare YO-PRO-1, propidium, and calcein uptake into U-937 cells after nanosecond (6 ns) and microsecond (220 µs) electric pulse exposures. Each of the three dyes exhibits a different pattern. Calcein shows no preference for anode- or cathode-facing entry that is detectable with …

Today's Environmental Issues: Democrats And Republicans, Rob Tench

Libraries Faculty & Staff Publications

Walker (political science, Elmhurst Coll.) and several contributors provide an accurate, even-handed overview of Democratic and Republican parties’ policy positions on the most important environmental issues and challenges facing the United States.

Association Between Physical Activity And Self-Rated Health Among Pediatric Patients With Type 1 Diabetes Mellitus Who Lack Diabetes Care, Hyun Jin Kwon, Hyok Ju Maeng, Justin A. Haegele, Young Ah Lee, Yeon Soo Kim

Human Movement Studies & Special Education Faculty Publications

Background: Even though a number of studies have verified the positive effect of physical activity (PA) on self-related health (SRH) no previous research has examined this association among pediatric patients with Type 1 diabetes mellitus (T1DM).

Objective: The purpose of this study was to investigate the association between regular physical activity (PA) and self-rated health (SRH) in pediatric patients with Type 1 diabetes mellitus (T1DM) who lacked diabetes care.

Methods: We conducted a retrospective study among pediatric patients with T1DM who lacked diabetes care and were enrolled in a diabetes education program between January 2011 to January 2015 at the …

Improving Public Health Readiness For Sea Level Rise: A New Initiative In Coastal Virginia, Steven M. Becker

Community & Environmental Health Faculty Publications

Sea level has been rising around the world, and in recent decades, the rate has been accelerating. Because rising seas have the potential to directly or indirectly affect the health of vast numbers of coastal communities and inhabitants, public health agencies and professionals—in conjunction with other fields—have a pivotal role to play in helping to protect populations, reduce and prevent health impacts, and foster resilience. This article discusses a novel effort that has been undertaken in Coastal Virginia to help prepare the next generation of public health professionals to grapple with sea level rise issues. The effort grew out of …

Wild-Type P53 Enhances Endothelial Barrier Function By Mediating Rac1 Signalling And Rhoa Inhibition, Nektarios Barabutis, Christiana Dimitropoulou, Betsy Gregory, John D. Catravas

Bioelectrics Publications

Inflammation is the major cause of endothelial barrier hyper-permeability, associated with acute lung injury and acute respiratory distress syndrome. This study reports that p53 "orchestrates" the defence of vascular endothelium against LPS, by mediating the opposing actions of Rac1 and RhoA in pulmonary tissues. Human lung microvascular endothelial cells treated with HSP90 inhibitors activated both Rac1- and P21-activated kinase, which is an essential element of vascular barrier function. 17AAG increased the phosphorylation of both LIMK and cofilin, in contrast to LPS which counteracted those effects. Mouse lung microvascular endothelial cells exposed to LPS exhibited decreased expression of phospho-cofilin. 17AAG treatment …

Alteration Of Metabolite Profiling By Cold Atmospheric Plasma Treatment In Human Myeloma Cells, Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen, Michael G. Kong

Bioelectrics Publications

BACKGROUND: Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheric plasma is a rapidly developed technology in recent years, which has been widely applied in biomedicine. Although plasma could efficiently inactivate various tumor cells, the effects of plasma on tumor cell metabolism have not been studied yet.

METHODS: In this study, we investigated the metabolite profiling of He plasma treatment on myeloma tumor cells by gas-chromatography time-of-flight (GC-TOF) mass-spectrometry. Meanwhile, by bioinformatic analysis such as GO and …

Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma And Induces Innate And Adaptive Memory Immune Mechanisms That Prevent Recurrence, Brittany P. Lassiter, Siqi Guo, Stephen J. Beebe

Bioelectrics Publications

Nano-pulse stimulation (NPS), previously called nsPEFs, induced a vaccine-like effect after ablation of orthotopic N1-S1 hepatocellular carcinoma (HCC), protecting rats from subsequent challenges with N1-S1 cells. To determine immunity, immune cell phenotypes were analyzed in naïve, treated and protected rats. NPS provides a positive, post-ablation immuno-therapeutic outcome by alleviating immunosuppressive T regulatory cells (Treg) in the tumor microenvironment (TME), allowing dendritic cell influx and inducing dynamic changes in natural killer cells (NKs), NKT-cells and T-lymphocytes in blood, spleen and liver. NPS induced specific increases in NKs and NKT-cells expressing CD8 and activation receptors CD314-NKG2D and CD161 (NK1.1) in the TME …

Cell Fragmentation And Permeabilization By A 1 Ns Pulse Driven Triple-Point Electrode, Enbo Yang, Joy Li, Michael Cho, Shu Xiao

Bioelectrics Publications

Ultrashort electric pulses (ns-ps) are useful in gaining understanding as to how pulsed electric fields act upon biological cells, but the electric field intensity to induce biological responses is typically higher than longer pulses and therefore a high voltage ultrashort pulse generator is required. To deliver 1 ns pulses with sufficient electric field but at a relatively low voltage, we used a glass-encapsulated tungsten wire triple-point electrode (TPE) at the interface among glass, tungsten wire, and water when it is immersed in water. A high electric field (2MV/cm) can be created when pulses are applied. However, such a high electric …

Tumor Cell Death After Electrotransfer Of Plasmid Dna Is Associated With Cytosolic Dna Sensor Upregulation, Katarina Znidar, Masa Bosnjak, Nina Semenova, Olga N. Pakhomova, Loree Heller, Maja Cemazar

Bioelectrics Publications

Cytosolic DNA sensors are a subgroup of pattern recognition receptors (PRRs) and are activated by the abnormal presence of the DNA in the cytosol. Their activation leads to the upregulation of pro-inflammatory cytokines and chemokines and can also induce cell death. The presence of cytosolic DNA sensors and inflammatory cytokines in TS/A murine mammary adenocarcinoma and WEHI 164 fibrosarcoma cells was demonstrated using real time reverse transcription polymerase chain reaction (RT-PCR), western blotting and enzyme-linked immunosorbent assay (ELISA). After electrotransfer of plasmid DNA (pDNA) using two pulse protocols, the upregulation of DNA-depended activator of interferon regulatory factor or Z-DNA binding …

Cold Atmospheric Plasma As A Potential Tool For Multiple Myeloma Treatment, Dehui Xu, Yujing Xu, Qingjie Cui, Dingxin Liu, Zhijie Liu, Xiaohua Wang, Yanjie Yang, Niaojuan Feng, Rong Liang, Hailan Chen, Kai Ye, Michael G. Kong

Bioelectrics Publications

Multiple myeloma (MM) is a fatal and incurable hematological malignancy thus new therapy need to be developed. Cold atmospheric plasma, a new technology that could generate various active species, could efficiently induce various tumor cells apoptosis. More details about the interaction of plasma and tumor cells need to be addressed before the application of gas plasma in clinical cancer treatment. In this study, we demonstrate that He+O₂ plasma could efficiently induce myeloma cell apoptosis through the activation of CD95 and downstream caspase cascades. Extracellular and intracellular reactive oxygen species (ROS) accumulation is essential for CD95-mediated cell apoptosis in response …