Digital Commons Network^™

Statistical Methods For Meta-Analysis In Large-Scale Genomic Experiments, Wimarsha Thathsarani Jayanetti

Mathematics & Statistics Theses & Dissertations

Recent developments in high throughput genomic assays have opened up the possibility of testing hundreds and thousands of genes simultaneously. With the availability of vast amounts of public databases, researchers tend to combine genomic analysis results from multiple studies in the form of a meta-analysis. Meta-analysis methods can be broadly classified into two main categories. The first approach is to combine the statistical significance (pvalues) of the genes from each individual study, and the second approach is to combine the statistical estimates (effect sizes) from the individual studies. In this dissertation, we will discuss how adherence to the standard null …

Assembly Of Ceramic Particles In Aqueous Suspensions Induced By High-Frequency Ac Electric Field, James E. John Iv

Mechanical & Aerospace Engineering Theses & Dissertations

Ceramic materials processed using colloidal methods have been the focus of a great deal of research aimed at tailoring the final structure and microstructure of the finished ceramic sample. To this end, various external field effects have been investigated to modify the suspension microstructure without manipulating the ceramic particles directly. In a previous work in the field of ice templating it has been shown that AC electric fields are able to produce microstructural changes in ice templated ceramics that have significantly improved the final mechanical properties. However, the mechanisms for this process are still not well understood in ceramics.

To …

Numerical Simulation Of Electroosmotic Flow Of Viscoelastic Fluid In Microchannel, Jianyu Ji

Mechanical & Aerospace Engineering Theses & Dissertations

Electroosmotic flow (EOF) has been widely used in various biochemical microfluidic applications, many of which often involve the use of viscoelastic non-Newtonian fluids. Due to the existence of the elastic effect, the viscoelastic EOF develops into chaotic flow under extremely low Reynolds numbers, which is known as elastic turbulence. The mechanism of elastic turbulence in electroosmotic flow remains unclear. Numerical simulation plays an important role in understanding the mechanisms of elastic turbulence. This dissertation is aimed to study the EOF of viscoelastic fluids in constriction microchannels under various direct current (DC) and alternating current (AC) electric fields. First, the EOF …

Atlantic Surfclam (Spisula Solidissima) Population Demographics And Distribution Along The Middle Atlantic Bight, Mauricio González Díaz

OES Theses and Dissertations

The Atlantic surfclam (Spisula solidissima) is a long-lived benthic biomass dominant organism that occurs on the Middle Atlantic Bight (MAB) continental shelf between 10 m and 50 m. Trends in Atlantic surfclam population specific growth and mortality rates were analyzed using four decades of age and length observations obtained from NOAA stock surveys from the 1980s to 2010s in six regions distributed along the MAB. Atlantic surfclam specific growth rates and asymptotic lengths were estimated from the age and length observations using the von Bertalanffy growth model. The analysis showed that the Atlantic surfclam median asymptotic length in …

Kinetic Simulations Of Active Nematic Polymers In Channel Flow, Lacey Savoie Schenk

Mathematics & Statistics Theses & Dissertations

Suspensions of active nematic liquid crystalline polymers exhibit complex phenomena such as spontaneous flows, pattern formations, and defects. They have many applications in industry, commercial settings, and our daily lives. We employ the Kinetic Model for our research, an extensive model that couples the Smoluchowski Equation and the incompressible Navier-Stokes Equations to solve for the active nanorod number density function–a function dependent on the polymer’s physical orientation and space at a given time. Using this function, we can derive the polymer’s polarity and nematic orientations as well as other rheological properties. In this research, we conduct numerical simulations of active, …

Instructional Systems Design And The Diffusion And Adoption Of Technology: (Volume 1), Miguel Ramlatchan (Author & Editor), Mark Parsons (Author), Meghan Soldani (Author), Josie Joswick Mendoza (Author), Maria Satre (Author), Brittany Spitz (Author), Jasmine Bundy (Author), Amanda Kline (Author)

Distance Learning Faculty & Staff Books

Instructional designers, instructional systems designers, and other educational technologists are, by their nature, innovators. These professionals apply and extend the applied science of learning, systems, communication, and instructional design theory to help students learn. Technology in some capacity is used to make the connections between subject matter experts, teachers, instructors, and their learners. It is common for instructional designers to seek new tools, techniques, and innovations for the improvement of learning, access, quality, and student satisfaction. However, the adoption and diffusion of new educational technology and innovation is a complex process that depends on many variables. Understanding these processes and …

Modification Of The Tumor Microenvironment Enhances Anti-Pd-1 Immunotherapy In Metastatic Melanoma, Guilan Shi, Megan Scott, Cathryn G. Mangiamele, Richard Heller

Bioelectrics Publications

Resistance to checkpoint-blockade treatments is a challenge in the clinic. Both primary and acquired resistance have become major obstacles, greatly limiting the long-lasting effects and wide application of blockade therapy. Many patients with metastatic melanoma eventually require further therapy. The absence of T-cell infiltration to the tumor site is a well-accepted contributor limiting immune checkpoint inhibitor efficacy. In this study, we combined intratumoral injection of plasmid IL-12 with electrotransfer and anti-PD-1 in metastatic B16F10 melanoma tumor model to increase tumor-infiltrating lymphocytes and improve therapeutic efficacy. We showed that effective anti-tumor responses required a subset of tumor-infiltrating CD8⁺ and CD4 …

Illuminator, Volume 5, Issue 3, Batten College Of Engineering And Technology, Old Dominion University

College of Engineering & Technology Newsletter

October 2022 issue of Illuminator, a monthly publication of ODU's Batten College of Engineering and Technology.

Chapter 12: Perception In Instructional Message Design, Shuree Altantsetseg

Instructional Message Design, Volume 2

This chapter aims to discuss perception from various academic disciplines and its relations and effects on information processing in instructional message design. Improved awareness of this concept assists instructional designers in conveying their message effectively and improves effective instruction in immersive learning environments. In this chapter, Gestalt, neurological, ecological, and computational perspectives and processes on perception are first discussed and followed by applications in instructional message design and instructional design.

Chapter 07. Message Design For Healthcare Simulation, Maria Satre

Instructional Message Design, Volume 2

Simulation is a teaching method that motivates and engages learners (Ifenthaler et al. 2020; Martin & Betrus, 2019), can provide better student performance outcomes compared to traditional classroom education (Chernikova et al. 2020; D’Angleo et al., 2014; Di Natale et al., 2020; Gralnick & Levy, 2011; Pellas et al., 2019), and can even replace some real-world learning experiences (Alexander et al., 2015). Instructional designers who develop healthcare simulations should use relevant learning theory and instructional message design to ensure that the simulation is learner-centered and based in evidence-based practice to maximize the potential for the learning experience.

Wetlands In Our Backyard: A Review Of Wetland Types In Virginia State Parks, Kirsten Bauer, Benjamin K. Campbell

Virginia Journal of Science

Wetlands constitute a significant component of Virginia’s natural resources and heritage. Though historically they have been discounted—and often denigrated—the exceptional value of wetlands is currently growing in recognition and appreciation. In addition to the value provided by extracted resources and ecological regulation, wetlands also offer people the opportunity to enrich themselves through cultural, educational, and recreational pursuits. The state parks of Virginia provide access to a variety of ecosystems, including a wide array of wetland types. In this review, we document the diversity of wetlands in Virginia State Parks through a typology that groups wetland systems into the three principal …

Taiwan And The Pacific Islands: Exploring The Green/Blue Possibilities, Fabrizio Bozzato

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

[First paragraph] The Pacific Island nations face unique developmental challenges and vulnerability issues that, in some cases, threaten their very existence. The Islands’ political and civil society leaders have recently embraced a vision of inclusive and sustainable development for remodeling their countries’ ‘brown economies’ into people-centered green/blue economies fostering poverty eradication. However, moving to a new socio-economic paradigm is a goal that the Pacific Island countries cannot achieve alone. They need reliable partners with green-tech capability and innovative aid policies. Taiwan is potentially the ideal partner for building a new framework for Pacific islanders and enabling them to reach for …

Vagabond: The Trans-Species Ecologies Of Plant/Human Encounters, Hubert Alain

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

[First paragraph] The opening scene of the acclaimed documentary King Corn (2007) shows Ian Cheney and Curtis Ellis, main protagonists, learning that corn constitutes one of the main carbon molecules of their hair. Segue to introduce the crop’s omnipresence in North American processed foods, principally used as sweetener, starch and animal feeds, the almost banal scientific fact presented in this scene is mesmerizing, providing a somewhat embodied support to the popular environmentalist saying “you are what you eat,” or to Donna Haraway’s poetic understanding of bodies and species as “full of their own others, full of messmates, of companions” (Haraway …

Language And Power In Social Movements: Hearing All The Voices In Food System Advocacy Narratives, Dianna Winslow

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

[From first paragraph] Everyone must eat. It is this immediate and personal connection to food which drives public and scholarly interest in the complex narratives emerging in what is becoming known as the “food movement”—activism on a global scale that is challenging how the industrialized production, distribution and consumption of food is affecting environmental conditions, food sovereignty and security, human health and wellness, and cultural identities. As the number of food advocacy groups promoting different, yet overlapping, public concerns continues to increase, so does the flow of language used by these groups to shape collective identities and political stances, which …

Is Trash Hybrid?, Todd Levasseur

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

[From first paragraph] The scholarship focusing on globalization over the last thirty years has achieved impressive gains in nuance and understanding. Some of the more prominent approaches to study globalization that have developed in this period include network, feminist, gender, economic, political, media, religious, diaspora, and migratory lenses. All of these lenses are adroitly utilized by scholars to help us better understand globalization and their use helps to shape the field of global studies. This article argues that environmental humanities scholars must build upon insights from these disciplines, while bringing scholarly tools from the environmental sciences into their research projects, …

A “Kind Of Impiety”: Deforestation, Sustainability, And Self In The Works Of Samuel Richardson And Yuan Mei, Samara Cahill

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

[From first paragraph] In line with scholarship by Timothy Clark, Erin Drew and John Sitter, David Fairer, and Tom Keymer, I argue that it is a distortion of eighteenth-century literature to identify the Romantic period as the origin of modern ecological consciousness. Indeed, according to Drew and Sitter, the dismissive characterization of the eighteenth century in current ecocritical scholarship is “puzzling” because much of the literature of that period “not only deals with the natural world but does so in ways arguably more ecocentric and less egocentric in orientation than much Romantic writing” (227).

State Of The University Address, 2022, Brian O. Hemphill Ph.D

State of the University Addresses

Old Dominion University President Brian O. Hemphill's first State of the University Address presented September 2, 2022 at Chartway Arena.

Monarch Science Observer, Volume 15, College Of Sciences, Old Dominion University

College of Sciences Newsletter

Fall 2022, issue of Monarch Science Observer, ODU Colleges of Sciences Newsletter.

Undergraduate Engineering And Education Students Reflect On Their Interdisciplinary Teamwork Experiences Following Transition To Virtual Instruction Caused By Covid-19, Kristie S. Gutierrez, Jennifer J. Kidd, Min Jung Lee, Pilar Pazos, Krishnanand Kaipa, Stacie I. Ringleb, Orlando Ayala

Teaching & Learning Faculty Publications

This study explores undergraduate engineering and education students’ perspectives on their interdisciplinary teams throughout the rapid transition to online learning and instruction from a face-to-face to a virtual format. In this qualitative study, students’ reflections and focus groups from three interdisciplinary collaborations were analyzed using the lens of Social Cognitive Theory. COVID-19 created a dramatic change in the environment such that the most immediate and direct impact on students’ experiences was on the environmental aspects of Bandura’s triadic reciprocal determinism model, which then triggered behavioral and personal responses to adapt to the new environment. Subsequent evidence of reciprocal effects between …

2022 Undergraduate Research Symposium: Full Program, Honors College, Old Dominion University

Undergraduate Research Symposium

No abstract provided.

Perspectives On Living Shorelines: Marine Contractors And Agents In Southeast Virginia, Michelle Covi, Juita-Elena (Wie) Yusuf

Presentations, Lectures, Posters, Reports

No abstract provided.

Mental Health Counselors’ Perceptions Of Professional Identity As Correctional Counselors In An Integrated Behavioral Health Care Setting, Jeanel L. Franklin

Counseling & Human Services Theses & Dissertations

This study explores the professional identity of clinical mental health counselors employed as correctional counselors in an integrated behavioral health (IBH) setting. Previous research has documented the attitudes, perceptions, and experiences of mental health counselors working in IBH as well as their experiences engaging in interprofessional collaboration. However, researchers have yet to explore how clinical mental health counselors in correctional settings perceive their professional identity and what aspects of their professional roles impact their identity development. This study utilized an interpretive phenomenological approach (IPA) to describe, understand, and interpret the meaning of four correctional counselors’ perceptions of their professional identities …

A Comparison Of Sorority Women And Non-Sorority Women’S Alcohol Use: Perception, Rate Of Use, And Consequences, Betsy Zimmerman

Counseling & Human Services Theses & Dissertations

While alcohol use and Greek Life on college campuses have often become synonymous, little is known about the rate of use or the consequences of use for sorority women specifically. Gender has been identified as a risk factor relating to substance use on college campuses; however, there is a gap in the literature concerning compounding factors that influence substance abuse, such as membership in a Greek-lettered organization. With approximately 300,000 college women involved in Greek-lettered organizations annually (NPC, 2019), little is known about the impact of alcohol use for sorority women on college adjustment. An exploration of the perception of …

Design, Synthesis And Characterization Of Triazole Based Glycoconjugates And 4,6-Acetal Protected D-Glucosamine Derivatives As Low Molecular Weight Gelators, Pooja Sharma

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are small molecules that can form gels in either organic solvents or water in their pure form or as mixtures. LMWGs self-assemble through noncovalent interactions such as hydrogen bonding, halogen bonding, van der Waals interactions and hydrophobic forces in solvents. They have shown great potential in biomedical industry, catalysis and environmental remediation to name a few. Moreover, the formation of metallogels can be used for detection of various ions as well as catalysis, which adds a new dimension to their applications. Among many classes of LMWGs based on the type of functional groups used, carbohydrate …

Examining The Culturally Responsive Teaching Self-Efficacy Of Teacher Candidates In Urban Immersive Residency Programs, Latanya M. Sutphin

Teaching & Learning Theses & Dissertations

Urban immersive residency programs have emerged from partnerships between K-12 schools and universities offering teacher candidates a year-long field experience alongside coursework aligned with the framework and practices in the schools (Zeichner & Bier, 2015). The goals of these programs include teacher candidates applying what they learn during preparation into practice and getting good student outcomes, while building their confidence in teaching diverse students. This study used situated learning theory (Lave & Wenger, 1991) to position urban immersive residency programs as a community of practice where teacher candidate’s self-efficacy and understanding of culturally responsive teaching overlap. A mixed methods design …

Clostridioides Difficile Biofilm And Spore Production In Response To Antibiotics And Immune Stress, Adenrele M. Oludiran

Chemistry & Biochemistry Theses & Dissertations

The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. C. difficile, an anaerobic spore-forming Gram-positive pathogenic bacterium, is a major cause of hospital-acquired infections. C. difficile persists in the environment and spreads the infection to new hosts in the form of dormant spores and can persist within hosts as surface-attached biofilms. These studies investigate bacterial vegetative cell survival, biofilm formation, and sporulation in response to stress. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating …

Applied Deep Learning: Case Studies In Computer Vision And Natural Language Processing, Md Reshad Ul Hoque

Electrical & Computer Engineering Theses & Dissertations

Deep learning has proved to be successful for many computer vision and natural language processing applications. In this dissertation, three studies have been conducted to show the efficacy of deep learning models for computer vision and natural language processing. In the first study, an efficient deep learning model was proposed for seagrass scar detection in multispectral images which produced robust, accurate scars mappings. In the second study, an arithmetic deep learning model was developed to fuse multi-spectral images collected at different times with different resolutions to generate high-resolution images for downstream tasks including change detection, object detection, and land cover …

Nestedness And Modularity Of Avian Metacommunities Across Gradients Of Chesapeake Bay Island Characteristics, Grant Walter Bowers

Biological Sciences Theses & Dissertations

Islands are not only great models for understanding the ways in which communities are linked by the dispersal of their members to form metacommunities, but are of particular interest to conservationists. One important aspect of metacommunity structure is the degree of nestedness—whether or not less speciose communities are perfect subsets of more speciose communities. Another important metric of metacommunity structure is modularity—the degree to which communities belong to modules composed of other communities that share the same species but have little species overlap with communities from different modules. Environmental gradients have received insufficient attention as predictors of metacommunity nestedness and …

Accommodations, Inclusion, And Communication With Students With Disabilities In The Music Classroom, Cora M. Wilson

Music Theses & Dissertations

The purpose of this study was to learn how music educators create inclusivity in their classroom and how to better do that without potentially alienating the students with disabilities. For this study, inclusivity is defined as providing an equal opportunity for participation and education in the classroom. It is also to bring more awareness to disabilities and how they can and should be managed in the classroom. The goal for this study is to aid in informing educators on how to enable students with disabilities to be included without feeling alienated or having undue attention drawn to them.

As the …

Emotion Detection Using An Ensemble Model Trained With Physiological Signals And Inferred Arousal-Valence States, Matthew Nathanael Gray

Electrical & Computer Engineering Theses & Dissertations

Affective computing is an exciting and transformative field that is gaining in popularity among psychologists, statisticians, and computer scientists. The ability of a machine to infer human emotion and mood, i.e. affective states, has the potential to greatly improve human-machine interaction in our increasingly digital world. In this work, an ensemble model methodology for detecting human emotions across multiple subjects is outlined. The Continuously Annotated Signals of Emotion (CASE) dataset, which is a dataset of physiological signals labeled with discrete emotions from video stimuli as well as subject-reported continuous emotions, arousal and valence, from the circumplex model, is used for …