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Artificial Intelligence Liability: Implications And Best Practices For Legal Professionals And Ai Developers, Alyssa Heinze Apr 2026

Artificial Intelligence Liability: Implications And Best Practices For Legal Professionals And Ai Developers, Alyssa Heinze

Undergraduate Student Symposium

The rapid integration of artificial intelligence into the legal profession has transformed legal research, drafting, and decision-making, while simultaneously introducing novel ethical, regulatory, and liability risks. As attorneys increasingly rely on generative AI systems, concerns surrounding hallucinations, bias, confidentiality breaches, and deceptive outputs have exposed both legal professionals and AI developers to heightened scrutiny. This presentation examines the current and emerging landscape of artificial intelligence liability in the United States, with particular attention to the absence of a comprehensive federal regulatory framework and the constitutional controversy surrounding Executive Order 14179 and its preemption of state AI legislation. By analyzing federal …

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Addressing Co-Occurring Mental Illness In Adults With Autism Spectrum Disorder, Ella Riddle Apr 2026

Addressing Co-Occurring Mental Illness In Adults With Autism Spectrum Disorder, Ella Riddle

Undergraduate Student Symposium

Co-occurring mental health conditions are highly prevalent among adults with autism spectrum disorder (ASD) and represent a significant area of concern in adult mental health care. A 2014 study published in the Journal of Autism and Developmental Disorders reports that between 73%-81% of adults with ASD meet the criteria for at least one co-occurring mental illness (Buck et al., 2014). The national average of adults living with mental illness, as determined in 2022, is 23.1% (National Institute of Health, 2022). As these statistics illustrate, adults with ASD experience high rates of co-occurring mental illness, yet these conditions are often treated …

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Marine Mammal Bone As Recorder Of Trace Element Dynamics During The Past 5500 Years In The North Pacific Ocean, Aidan Pflieger Apr 2026

Marine Mammal Bone As Recorder Of Trace Element Dynamics During The Past 5500 Years In The North Pacific Ocean, Aidan Pflieger

Undergraduate Student Symposium

The North Pacific Ocean has been geologically dynamic and biologically diverse since the Last Glacial Maximum (20,000 ybp). Natural fluctuations in island arc volcanism and climate likely influence the input of essential and nonessential trace elements to the Aleutian Island Archipelago, even to present day. Accumulation of these elements in the region's marine food webs provides a measure of natural fluctuations in the environment. Ninety-eight samples of tephra-preserved marine mammal bone (primarily pinnipeds) sourced from temporally identified archeological Aleut midden sites on Unalaska Island (5500-200 ypb), were analyzed for 20 trace elements using inductively coupled plasma mass spectrometry (ICP-MS). Concentrations …

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The Impact Of Mouthwashes On Oral Microbiome Communities In University Students, Jinil Milind Shah, Simar Mathoun, Richa Rajesh, Hyungkyu Kim, Varsha Adabala, Chelsea Borja, Rhianna Jacob, Trisha Jois, Jordan Monteiro, Noura Naami Apr 2026

The Impact Of Mouthwashes On Oral Microbiome Communities In University Students, Jinil Milind Shah, Simar Mathoun, Richa Rajesh, Hyungkyu Kim, Varsha Adabala, Chelsea Borja, Rhianna Jacob, Trisha Jois, Jordan Monteiro, Noura Naami

Undergraduate Student Symposium

The oral cavity hosts a complex microbial ecosystem, which can be altered due to physical or chemical exposures, such as dental mouthwashes. This study examined the short-term impact of two commonly used Listerine mouthwashes, alcohol-containing and alcohol-free, compared to water (as control) on the oral microbiome and salivary pH in a college student population. Oral swab samples were collected after the oral rinse and salivary pH measurements were obtained to assess immediate biochemical changes. Microbial DNA was extracted and the V4 region of the 16S rRNA gene was amplified using PCR. Sequencing was performed on an Illumina MiSeq platform, producing …

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Identifying Biomarkers Indicative Of Active And Passive Exposure To Electronic Cigarette Aerosols, Armaan Makwana, Om Patel, Suhani Makwana, Chelsea Nguyen Apr 2026

Identifying Biomarkers Indicative Of Active And Passive Exposure To Electronic Cigarette Aerosols, Armaan Makwana, Om Patel, Suhani Makwana, Chelsea Nguyen

Undergraduate Student Symposium

Electronic cigarettes (e-cigarettes) have grown in popularity as they are portrayed as a healthier alternative to conventional cigarettes. However, recent studies have identified the presence of toxic chemicals in e-cigarettes liquids and their aerosols. While active users of e-cigarettes (AE) are directly exposed to these chemicals, little is known about the extent of exposure in non-users who are passively exposed (PE) to e-cigarette aerosols. In this study, we analyzed saliva samples from active users and non-users who are either passively exposed (those who live or work with an active user) or not exposed to e-cigarette aerosols to determine whether their …

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Exploring The Presence Of Persistent Organic Pollutants (Pops) In The Muscle Tissue Of Various Alaskan Salmon Species, Sara Simonetti, Victoria Angelini, Vanessa Miro Apr 2026

Exploring The Presence Of Persistent Organic Pollutants (Pops) In The Muscle Tissue Of Various Alaskan Salmon Species, Sara Simonetti, Victoria Angelini, Vanessa Miro

Undergraduate Student Symposium

Alaska supplies 60% of the fish consumed in the United States; therefore, determining the presence of persistent organic pollutants (POPs) in fish sourced from that area is critical. POPs are chemical compounds that are classified as one of 209 congeners of either polychlorinated biphenyls (PCBs) or polybrominated diphenyl ethers (PBDEs). They resist degradation and contribute to a range of harmful effects to both humans and wildlife, such as cancers and birth defects. Their introduction into the environment stemmed from their industrial and agricultural usage. However, despite being banned by the Stockholm Convention in 2004, they continue to be present in …

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Assessing Sediment Composition, Organic Matter, Metal Contamination, And Ecological Risks In Port Everglades, Florida, Elisa Prodhomme, Gabrielle Spankus Apr 2026

Assessing Sediment Composition, Organic Matter, Metal Contamination, And Ecological Risks In Port Everglades, Florida, Elisa Prodhomme, Gabrielle Spankus

Undergraduate Student Symposium

Port sediments often accumulate heavy metals and organic pollutants from anthropogenic inputs. The planned expansion of Port Everglades (Fort Lauderdale, Florida, USA) raises concern that dredging may remobilize contaminated sediments, potentially affecting nearby benthic habitats, including coral reefs. To assess sediment quality, eighteen cores were collected from five port sites and one control site, along with additional surface sediments. Cores were sectioned at 10 cm intervals and analyzed for 14 metals (ICP-MS), percent organic matter, and grain size. Geo-accumulation index results indicated moderate to strong contamination by As and Mo, while ecological risk assessments suggested moderate to high overall metal …

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Comparative Profiling Of Persistent Organic Pollutants In Alaskan Pink Salmon Roe And Muscle Tissue (Oncorhynchus Gorbuscha), Aleena Thomas, Megan Bailey, Luisa Torres Apr 2026

Comparative Profiling Of Persistent Organic Pollutants In Alaskan Pink Salmon Roe And Muscle Tissue (Oncorhynchus Gorbuscha), Aleena Thomas, Megan Bailey, Luisa Torres

Undergraduate Student Symposium

Persistent organic pollutants (POPs) are toxins that bioaccumulate through food chains--especially in marine ecosystems. They are primarily classified as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), each with 209 congeners associated with adverse human health outcomes such as cancer. Despite bans placed during the 2004 Stockholm Convention on Persistent Organic Pollutants, POP concentrations have remained consistent. Alaskan pink salmon (Oncorhynchus gorbuscha) are integral to Southeast Alaskan River ecosystems as a major food source for humans and animals. Detecting POPs in roe provides evidence of maternal offloading, indicating that these pollutants persist across life stages and generations. Salmon …

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Modeling The Disruption Of Binding Of Three Ige Antibodies With Six Mutated Interaction Sites On The Arah2 Allergen, Amaan Khan, Hansi Parmar, Jyothi Vivekananda Apr 2026

Modeling The Disruption Of Binding Of Three Ige Antibodies With Six Mutated Interaction Sites On The Arah2 Allergen, Amaan Khan, Hansi Parmar, Jyothi Vivekananda

Undergraduate Student Symposium

Peanut allergy is a life-threatening food allergy that affects millions of children and adults across the world. This issue presents serious public health concerns and heavy interest from the scientific community to find viable treatments that minimize immunological side effects. To better understand and explain the peanut allergy response, the literature was examined, and a 3D model was printed based on two protein database files. Arachis hypogaea 2 (Arah2) is the dominant peanut allergen protein. When Arah2 binds IgE antibodies, a strong allergic response is triggered. This reaction makes treating allergy patients with Oral Immunotherapy (OIT) difficult due to adverse …

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Endoparasites In Magnificent Frigatebirds (Fregata Magnificens Rothschildi) From Southeast Florida, Usa, Isabelle Petty, Alexia Hilber Apr 2026

Endoparasites In Magnificent Frigatebirds (Fregata Magnificens Rothschildi) From Southeast Florida, Usa, Isabelle Petty, Alexia Hilber

Undergraduate Student Symposium

The Magnificent Frigatebird (Fregata magnificens) is a pelagic seabird widely distributed across tropical and subtropical regions. Due to its wide-ranging foraging behavior and fish-based diet, these birds are susceptible to parasitic infections. However, little is known about the species' endoparasite communities. Despite its ecological importance, research on this species remained limited, particularly regarding the diversity and distribution of endoparasites. This study aims to investigate the endoparasite community in these birds. Specimens were collected from multiple rehabilitation centers from southeast Florida. A total of six individuals were examined (MAFR 2000, 3105, 3106, 3107, 3108, and 3109) for parasite presence …

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Disrupting Stat3 Signaling In Glioblastoma Stem Cells Using Nitro-Modified Curcumin Analogs, Sneha Subhash, Swara Chindhade, Maria Moreno Hollweg, Kyuree Chang Apr 2026

Disrupting Stat3 Signaling In Glioblastoma Stem Cells Using Nitro-Modified Curcumin Analogs, Sneha Subhash, Swara Chindhade, Maria Moreno Hollweg, Kyuree Chang

Undergraduate Student Symposium

Signal Transducer and Activator of Transcription 3 (STAT3) is frequently overactivated in cancers, including glioblastoma (GBM), where its dysregulation is associated with aggressive disease and poor patient survival. STAT3 supports tumor progression by promoting proliferation, resistance to apoptosis, maintenance of cancer stem cells, and immune suppression. Although numerous STAT3 inhibitors are under preclinical and clinical evaluation, none have yet achieved FDA approval. GBM remains a highly lethal brain cancer with limited therapeutic options, underscoring the need for new targeted treatments. Nitro-containing compounds, known for their strong electron-withdrawing characteristics, are emerging as potential anticancer agents. A library of 41 nitro-containing chalcones …

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Ticked Off: A Systematic Review Of Alpha-Gal Syndrome Mechanisms Apr 2026

Ticked Off: A Systematic Review Of Alpha-Gal Syndrome Mechanisms

Undergraduate Student Symposium

Alpha-gal syndrome is characterized by an IgE-mediated immune response against galactose-α-1,3-galactose. In the United States, the principal vector is the Lone Star tick, whose range has expanded nationwide. 110,000 cases have been reported since 2010, with the CDC estimating 450,000 as many cases go unrecognized. Vomiting, difficulty breathing, and hypotension can occur immediately or hours after exposure. Ongoing exposure to alpha galactose with AGS increases mast cell inflammatory response, raising coronary artery disease risk. Perioperative ingredients like gelatin, monoclonal antibodies, and stearic acid have triggered anaphylactic shock in AGS patients. These complications hinder diagnosis. The inclusion criteria required original research …

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Snapping Shrimp Acoustic Activity As An Indicator Of Ecosystem Health Across Mangrove, Seagrass, And Coral Reef Habitats In The Florida Keys, Catherine Salazar, Alexander Wheeler Apr 2026

Snapping Shrimp Acoustic Activity As An Indicator Of Ecosystem Health Across Mangrove, Seagrass, And Coral Reef Habitats In The Florida Keys, Catherine Salazar, Alexander Wheeler

Undergraduate Student Symposium

Mangroves, coral reefs, and seagrass provide refugia, nursery areas, and feeding grounds for many marine species. These ecosystems have faced declines in habitat complexity through natural and anthropogenic causes. Passive acoustic monitoring (PAM) is used to track changes in habitat characteristics through the monitoring of acoustic species, like snapping shrimp. Snapping shrimp are among the most active species inhabiting shallow subtropical marine environments, and their abundance, often tracked through their acoustic activity, are strong indicators of a healthy ecosystem. This study compares the acoustic activity of snapping shrimp across mangrove, seagrass, and coral reef habitats in Key Largo, Florida, as …

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Sold For Parts: Moral Connections Between Paid Surrogacy And Paid Organ Donation, Alessandra Coke Apr 2026

Sold For Parts: Moral Connections Between Paid Surrogacy And Paid Organ Donation, Alessandra Coke

Undergraduate Student Symposium

Throughout this presentation, I make ethical arguments about paid surrogacy, based on established arguments regarding paid living organ donation possible due to similarities between the procedures. I establish the differences between conceptualizations of surrogacy: unpaid/altruistic and paid/compensated, and clarify what is meant by paid surrogacy. The primary similarity between paid living organ donation and paid surrogacy is that both practices are a 'voluntary' violation of bodily integrity for financial benefit. I argue that both practices due to financial incentives cannot truly be seen as voluntary. I argue that the reasons that are used to understand paid living organ donation as …

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Advances In Aortic Valve Replacement For The Recovery Of Elderly Patients In Southern Florida, Khushi Faldu Apr 2026

Advances In Aortic Valve Replacement For The Recovery Of Elderly Patients In Southern Florida, Khushi Faldu

Undergraduate Student Symposium

Aortic stenosis, a narrowing of the aortic valve, is a significant health burden in aging populations, as in Broward County, Florida, where the elderly demographic is rapidly expanding. The classical approach to valve replacement is performed via Surgical Aortic Valve Replacement (SAVR). Recently, Transcatheter Aortic Valve Replacement (TAVR), a minimally invasive alternative, has emerged as a life-changing option for patients with a high surgical risk. Using inductive methods, this study compiled and analyzed data from existing research records and publications comparing endothelial recovery following TAVR and SAVR. We aim to design a teaching case study to highlight how procedural choice …

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When Peers Matter: Peer Communication And The Association Between Parental Dependence And Superiority Cognitions, Preya Pandya, Bala Sivani Paddala, Anisha Nandra Apr 2026

When Peers Matter: Peer Communication And The Association Between Parental Dependence And Superiority Cognitions, Preya Pandya, Bala Sivani Paddala, Anisha Nandra

Undergraduate Student Symposium

Although parent-child relationships have been widely studied during childhood and adolescence, less attention has been given to how these relationships continue to influence adjustment during emerging adulthood. This developmental period is marked by instability and exploration, as young adults begin transitioning into adult roles such as higher education, employment, and long-term relationships. Research suggests that parenting continues to matter during this time, with successful separation-individuation representing a normative developmental task. Excessive parental dependence, however, may be associated with maladjustment. At the same time, peers play an increasingly important role in emerging adulthood, and positive peer relationships are often linked to …

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Reengineering Bone Health: Preventing Steroid-Induced Osteoporosis Without Jaw Damage, John Voudouris Apr 2026

Reengineering Bone Health: Preventing Steroid-Induced Osteoporosis Without Jaw Damage, John Voudouris

Undergraduate Student Symposium

Glucocorticoid ("steroid") drugs are essential for treating autoimmune diseases, but long-term use often weakens bones, leading to a condition called glucocorticoid-induced osteoporosis (GIO). In the United States, steroids such as prednisone and dexamethasone are prescribed to over 10 million patients annually, and roughly 30% of long-term users develop GIO, contributing $20-30 billion in annual health-care costs. To this end, bisphosphonates are commonly used to treat GIO by preventing bone-loss; however, they can also cause a serious adverse effect called medication-related osteonecrosis of the jaw (MRONJ). Thus, safer jaw-protective treatments are urgently needed. In this study, we tested a different strategy …

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Analyzing The Variation In Microplastic Intake Of Waterhyacinth And Pennywort In Lake Okeechobee, Aashvi Gowrisankar Apr 2026

Analyzing The Variation In Microplastic Intake Of Waterhyacinth And Pennywort In Lake Okeechobee, Aashvi Gowrisankar

Undergraduate Student Symposium

The Florida Everglades ecosystem faces many threats, including municipal pollution and agricultural runoff. This study compares the microplastic intake of two types of floating vegetation in Lake Okeechobee. Water hyacinth (Pontederia crassipes) has a greater root mass and surface area than its native equivalent pennywort (Hydrocotyle umbellate). We hypothesize that water hyacinth would have greater microplastic intake due to its increased capillary action. Our project was conducted using three guiding questions: which plant type had the greatest microplastic intake, did accumulation vary with location, and did concentration vary among roots, stems, and leaves in each plant …

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From Prediction To Prevention: How The Va Uses Analytics To Reduce Chronic Disease And Mental Health Risk, Leelakrishna Angadala Apr 2026

From Prediction To Prevention: How The Va Uses Analytics To Reduce Chronic Disease And Mental Health Risk, Leelakrishna Angadala

Undergraduate Student Symposium

Predictive analytics has become an essential component of preventive care strategies within the Veterans Health Administration (VHA), which serves a medically and psychosocially complex population at elevated risk for chronic disease and mental health conditions. This research examines how the VHA has leveraged predictive analytics to improve early identification, prevention, and targeted intervention for chronic illnesses and mental health disorders. Specifically, it explores established initiatives such as the Care Assessment Needs (CAN) score for identifying veterans at high risk of hospitalization or mortality, the Reach Out, Stay Strong, Essentials for Veterans (REACH VET) program for suicide risk prediction and prevention, …

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The Role Of Hip Internal Rotation And Ground Reaction Forces On Lower Back Pain In Amateur Golfers, Katrina Arndt Apr 2026

The Role Of Hip Internal Rotation And Ground Reaction Forces On Lower Back Pain In Amateur Golfers, Katrina Arndt

Undergraduate Student Symposium

Lower back pain (LBP) is the most common musculoskeletal injury amongst golfers; the high velocity and repetitive motion of the golf swing on the lumbar spine leads to substantial compressive and torsional forces, making LBP primarily and overuse injury. An additional risk factor for LBP is limited lead hip internal rotation (LHIR), which forces the lumbar spine to compensate through excessive rotation. The golf swing also relies heavily on the efficient transfer of energy generated from the ground through the lower body, a process quantified by ground reaction forces (GRFs). While existing research has separately examined LBP and GRFs, there …

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Functional Annotation Of Gordonia Phage Minor Tail Proteins Using Alphafold And Structural Homology Searches, Harani Athwale, Mitchell Thenor Apr 2026

Functional Annotation Of Gordonia Phage Minor Tail Proteins Using Alphafold And Structural Homology Searches, Harani Athwale, Mitchell Thenor

Undergraduate Student Symposium

Bacteriophages are viruses that infect bacteria. The basic phage structure consists of a DNA or RNA genome encased in a capsid protein shell. Some may also have a tail, important for attachment and genome delivery into the bacterial host. Recently, the structure of mycobacteriophage Bxb1 was characterized and determined to have 10 minor tail proteins, each assigned a unique function. The genomes of Gordonia rubripertincta phages Fribs8, Genamy16, Alyssamiracle, and NovaSharks were annotated, depicting several minor tai proteins. However, the specific functions were not determined. Therefore, the goal of this research was to assign a specific function to the minor …

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Reproductive Experience Mitigates Cognitive Aging In A Mouse Model Of Alzheimer's Disease, Esperanza Barrios, Chana Vogel, Tej Chaudhari, Anna Roy, Shruthi Senthil, Greeshma Thomas Apr 2026

Reproductive Experience Mitigates Cognitive Aging In A Mouse Model Of Alzheimer's Disease, Esperanza Barrios, Chana Vogel, Tej Chaudhari, Anna Roy, Shruthi Senthil, Greeshma Thomas

Undergraduate Student Symposium

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that lacks effective treatment. Despite women having approximately twice the risk for developing AD, few studies have investigated sex-specific factors contributing to disease vulnerability. Among women, motherhood appears to be protective, although results are mixed, and this relationship could be explained by a third variable (e.g., genes) influencing both disease risk and fertility or fecundity. During an experiment directly tested the effects of motherhood by manipulating access to male breeders and examining neurodegeneration and cognitive aging in control (B6129) and transgenic mice used to model AD (3xTg-AD mice), we also compared reproductive …

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Modeling The Extracellular Matrix-Like Retinal Protein Pikachurin And Its Binding To Α-Dystroglycan And Gpcr (Gpr179), Mohit Belur, Khushi Raval, Riya Chelagiri, Rani Mehta Apr 2026

Modeling The Extracellular Matrix-Like Retinal Protein Pikachurin And Its Binding To Α-Dystroglycan And Gpcr (Gpr179), Mohit Belur, Khushi Raval, Riya Chelagiri, Rani Mehta

Undergraduate Student Symposium

Pikachurin is an extracellular matrix scaffold protein that links photoreceptor and ON-bipolar cell synapses by bridging the presynaptic dystroglycan complex and the postsynaptic receptor GPR179, ensuring precise synaptic alignment required for vision. Although its role in dystroglycanopathy associated visual phenotypes is well recognized, there is no published structural model showing how pikachurin engages α-dystroglycan or how this may influence GPCR linked synaptic signaling. This study computationally modeled full length Pikachurin using the complete nucleic acid sequence and available Protein Data Bank structures, integrating Jmol, AlphaFold, and literature-based analysis to predict domain organization, Ca2+-binding motifs, and glycan interaction sites …

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Effects Of Invasive Water Hyacinth On Boldness And Habitat Preference In Mosquitofish, Nicolas Borca, Chancellor Rockwell Marks Apr 2026

Effects Of Invasive Water Hyacinth On Boldness And Habitat Preference In Mosquitofish, Nicolas Borca, Chancellor Rockwell Marks

Undergraduate Student Symposium

Eastern mosquitofish (Gambusia holbrooki) are small freshwater fish that play an important role in aquatic food webs. Their behavior, especially boldness and risk-taking, can change depending on the type of habitat they occupy. In this study, we investigated how mosquitofish respond behaviorally to the presence of the floating invasive plant water hyacinth by comparing their boldness, preference for cover, and predation rates between water hyacinth and its native competitor, pennywort. Fish boldness was measured using a two-factor latency experiment. Fish were collected from freshwater locations in South Florida that either had the invasive plant or were free of …

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Porites Coral Colony Recovery At Caño Island , Sophia Bost Apr 2026

Porites Coral Colony Recovery At Caño Island , Sophia Bost

Undergraduate Student Symposium

Coral reefs are essential marine ecosystems and Porites lobata is an important Eastern Pacific reef-building coral that plays a major role in reef structure and ecosystem stability. This project documents Porites lobata responses to impacts associated witl1 the 2023-24 El NiÑo-Southern Oscillation, comparing coral tissue condition from 2024 and 2025. Overlapping digital images (~500 each year) utilizing two GoPro Hero 11 cameras were obtained from one, large (~13 m2) Porites lobata colony at Caño Island, Costa Rica. The program Agisoft Metashape was used to generate a 3D photogrammetry model constructed from these digital images. Living, bleached and dead …

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Analysis Of Accuracy In Ecgs Data Captured By Patients Using At-Home Ai-Assisted Device Compared To Qualified Clinician Recordings, Snehana Chinnola, Colin Pulickathadam Apr 2026

Analysis Of Accuracy In Ecgs Data Captured By Patients Using At-Home Ai-Assisted Device Compared To Qualified Clinician Recordings, Snehana Chinnola, Colin Pulickathadam

Undergraduate Student Symposium

Cardiovascular Diseases (CVDs) are a leading cause of death worldwide, accounting for 17.3 million deaths per year. Recent advancements in artificial intelligence (AI) introduce promising opportunities in the field of cardiology to support healthcare services outside traditional clinical settings. At-home care generally promotes patient independence and improved health outcomes, while staying cost-effective due to decreased hospital visits. This study will analyze deidentified patient pilot data to assess the feasibility and performance of AI-assisted at-home electrocardiogram (ECG) monitoring compared with standard clinician-obtained ECGs during routine clinical visits, focusing on signal quality and accuracy. Additionally, the data consistency will be examined to …

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Xct (Slc7a11) Regulationl Lessons From Cancer Research, Sravika Chirla, Rahul Pandit Apr 2026

Xct (Slc7a11) Regulationl Lessons From Cancer Research, Sravika Chirla, Rahul Pandit

Undergraduate Student Symposium

xCT is an amino acid antiporter that imports cystine in exchange for glutamate with a 1:1 ration in a concentration-dependent manner. Once inside the cell, cystine is quickly reduced to cysteine, the rate-limiting substrate for the main cellular antioxidant, glutathione. The function of xCT has been highlighted by the discovery of a new type of cell death, known as ferroptosis. Ferroptosis is a distinctive form of programmed cell death triggered by lipid peroxidation and the accumulation of reactive oxygen species, leading to cell damage and death. Numerous classes of cancers have shown overexpression of xCT, which correlates with worse outcomes …

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Distinct And Cooperative Effects Of Epigenetic Inhibitors On Cell Viability And Cell Cycle Regulation In Neuroblastoma Cells, Tamanna Dipen Shah, Anushka Ayanampudi, Shyam Jaganathan Apr 2026

Distinct And Cooperative Effects Of Epigenetic Inhibitors On Cell Viability And Cell Cycle Regulation In Neuroblastoma Cells, Tamanna Dipen Shah, Anushka Ayanampudi, Shyam Jaganathan

Undergraduate Student Symposium

Epigenetic dysregulation plays a central role in uncontrolled cell proliferation and therapeutic resistance in cancer. Consequently, targeting epigenetic regulators with small-molecule inhibitors has emerged as a promising strategy to disrupt cell cycle progression and induce tumor cell death. In this study, we evaluated the cytotoxic and molecular effects of two epigenetic-targeting agents, CM-272 and JNJ-64619178, administered as individual, simultaneous, and sequential treatments in neuroblastoma cell models. Cell viability was assessed using XTT assays, and changes in cell cycle regulatory proteins were analyze by Western blotting. Our results demonstrate that simultaneous combination treatment produced the greatest reduction in cell viability compared …

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Using X-Ray Crystallography To Inform Foldamer Drug Design, Isabella Garcia Apr 2026

Using X-Ray Crystallography To Inform Foldamer Drug Design, Isabella Garcia

Undergraduate Student Symposium

Foldamers are synthetic peptide oligomers that fold into well-defined three-dimensional structures, such as alpha-helices and beta-sheets. The goal of this project is to discover the solid-state confirmation of beta-amino acid foldamers that have potential as therapeutic molecules. This research represents an interdisciplinary collaboration between KAIST, a research university in South Korea, and NSU. We solved the single-crystal X-ray structures of two foldamers and then visualized their secondary structures and intermolecular contacts using Mercury. The first foldamer crystallized in the space group P21212 and demonstrated a continuous alpha-helical secondary structure, with the residue side chains evenly distributed …

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Temperature-Driven Changes In Lysis Kinetics Of Bacteriophages Infecting Gordonia Rubripertincta, Bianca Gonzalez, Jyothi Vivekananda Apr 2026

Temperature-Driven Changes In Lysis Kinetics Of Bacteriophages Infecting Gordonia Rubripertincta, Bianca Gonzalez, Jyothi Vivekananda

Undergraduate Student Symposium

Antibiotic resistance represents a significant global health crisis creating a necessity for alternative treatments to combat drug-resistant pathogens. One alternative treatment is bacteriophages, such as those targeting Gordonia rubripertincta, a gram-positive, aerobic actinomycete bacterium which has shown intrinsic resistance to some antibiotics. Furthermore, G. rubripertincta can cause endocarditis and CNS infections in immunocompromised individuals. Phages that successfully target G. rubripertincta (Alyssamiracle, Fribs8, Genamy16, and NovaSharks) have been discovered by NSU students. The phages work in a lytic manner, bursting the bacteria and releasing its viral progeny. The goal of this research was to evaluate the lysis kinetics of these …

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