Digital Commons Network^™

Metanalysis Of Genome Editing Using Crispr/Cas9 Technology Towards Hiv-1 Treatment, Nitya Alaparthy

Undergraduate Student Symposium

Genome editing, also called gene editing is a new branch of research that aims to explore means to modify genes of living organisms. Genome editing appears to have a promising future for researchers as it will further help to understand the gene function and develop ways to treat genetic or acquired diseases. Moreover, gene editing such as CRISPR/Cas9 technology can aid in manipulating the genome sequence, thereby, advancing treatments that will improve patients’ life span and quality of life. CRISPR/Cas9 technology supports three main mechanisms for genome editing, including plasmids-based methods, the direct intracellular distribution of the Cas9 mRNA, and …

Understanding The Origin Of Mutations Using Ab Initio Molecular Dynamics, Supratik Pasupuleti, Anthony Bianco

Undergraduate Student Symposium

Proton transfer within DNA base pairs is a possible origin for mutations which can ultimately lead to cancer. To better understand this potential source of mutations we have modeled this process using Ab Initio molecular dynamics simulations of model systems for DNA base pairs in water. These simulations have provided insight into how often and when proton transfer occurs in these systems while also highlighting the relationship between the likelihood of a proton transfer event and the way the water molecules are coordinated around the model system for DNA. This in turn has allowed for a greater understanding of potential …

Who Stressed The Dogs Out: A Case For Studying Mitochondrial Dna As A Novel Biomarker For Stress In Canines, Aidan Kunju, Ariana Ali, Ritika Kothur, Olivia Singleton

Undergraduate Student Symposium

Canines transiting through animal shelters experience extreme stress that is subsequently ameliorated by adoption into loving (human) homes. These transitions provide exceptional opportunities to study links between social stress and physiological processes, and to develop biomarkers for stress and social bonding with applications in both animal welfare and human health. Here, we propose a novel approach to the study of shelter-related stress in dogs, and of stress reversals following adoption. Specifically, we will quantify mtDNA dynamics in buccal swabs sampled during shelter intakes of canines at the Broward County animal shelter, as well as samples collected after these animals’ adoptions …

A Preliminary Survey Of Dog-In-Prison Programs Across The Us, Isabella Defilippis, Janan Abushaban, Mariya Baig, Ariel Cherry, Naziha Mustafa, Trini Somasundaram, Ashesh Soni

Undergraduate Student Symposium

The molecular effects of canine-human bonding have not been well-studied, but both species are deeply driven to seek out prosocial interactions. We therefore expect to see quantitative changes in both physiological biomarkers (e.g. cell-level phenotypes linked to psychiatric disease) and animal behavior on both sides of the ancient (>15,000 year old) symbiosis between dogs and humans when dogs and people form interspecies dyads. A compelling context for studying this involves "dog-in-prison" programs, in which incarcerated humans help to train canines for future lives as companionship or service animals. Notably, both the incarcerated humans and orphaned/stray dogs within such programs …

Comparative Study Of Homocoupling Reactions To Create 2,2'-Bipyridine Adducts, Ethan Depry, Hoa Le

Undergraduate Student Symposium

The project focuses on investigating the synthesis of 2,2’-bipyridine adducts for potential use as ligands in novel organometallic ruthenium complexes. The bipyridine building blocks, based on their excellent bidentate ligands with complexing abilities, will be incorporated into ruthenium complexes in a collaborative project, increasing the photosensitivity of these complexes, and opening the doors for many applications, ranging from synthetic photovoltaics to anti-cancer activity.

The aim of this study was to optimize the preparation of the 2,2’-bipyridine adducts. Prior studies conducted in our lab have compared several homo and cross coupling reactions. It was determined that homocoupling offers a more efficient …

Effect Of β-Lactamase Expression And Varying Metabolism On The Inoculum Effect, Kielan Singh, Vijay Patel

Undergraduate Student Symposium

Infections with antibiotic resistant bacteria pose a substantial challenge to the field of medicine. Accordingly, it is of the utmost importance that we understand the mechanisms by which bacteria resist antibiotics towards the development of novel drugs and treatment paradigms. One mechanism by which a population of bacteria can resist an antibiotic is the inoculum effect (IE). During IE, the initial density of the population determines the efficacy of the antibiotic; highly dense populations of bacteria require more antibiotics to kill the population as compared to less dense populations. One mechanism that has been proposed to explain IE is the …

Endoparasite Community Of Common Wood-Warblers (Family Parulidae) In Southeast Florida, Skylar Olsen

Undergraduate Student Symposium

Wood-warblers are small insectivorous passerine birds in the family Parulidae. They are among the first migratory birds in North America to begin their southward migration during the early autumn months and southeast Florida serves as a wintering ground. Although wood-warblers are common and widespread, knowledge of their endoparasite community composition is severely underrepresented in current literature. Carcasses were opportunistically collected from wildlife rescue centers in southeast Florida. The digestive tract of 90 birds representing 5 common wood-warbler species were examined for endoparasites: Common Yellowthroats (Geothlypis trichas), Ovenbirds (Seiurus aurocapilla), Black-and--White Warblers (Mniotilta varia), Palm Warblers (Setophaga palmarum), and American Redstarts …

Heavy Metal Contaminants In The Sciaenids From Lake Sabine, Katerina Sawickij

Undergraduate Student Symposium

Lake Sabine is a shallow, estuarine lake situated on the border between Texas and Louisiana with outflow to the Gulf of Mexico. The Louisiana side is a protected natural area while the Texas side is susceptible to pollution from several commercial industries as well as maintenance dredging. This study determined the concentrations of metal(loids) within commercially and economically important fish tissues and compared them intra- and inter-specifically using known diets and a range of sizes. Specimens were collected from Lake Sabine from April through October 2018 from four sciaenid fishes: Atlantic Croaker Micropogonias undulatus, Red Drum Sciaenops ocellatus, …

How Non-Profit Organizations Can Create A Hybrid Social Media Strategy Using Paid And Organic Posts, Samantha Carl Selorio

Undergraduate Student Symposium

The emergence of social media has changed the methods and approaches for communication between health agencies and their community. As such, non-profit organizations must learn to use social media to better promote their mission. Organizations can engage and capture the attention of their online target audience via paid posts. Broward Regional Health Planning Council (BRHPC), a non-profit organization, provides an analysis of how integrating social media tools has increased its social media presence. BRHPC already had an online presence on the social media sites Facebook, Twitter, Instagram, and LinkedIn. To increase the number of people in BRHPC’s intended audience who …

Induction Of Necroptosis In Mcf-7 Breast Cancer Cells Through Caspase-Independent Mechanisms Following Saha Treatment, Grace Waldron

Undergraduate Student Symposium

Currently, many anti-cancer drugs are known to induce programmed cell death (apoptosis) through activation of intrinsic or extrinsic pathways. However, many types of cancer cells have acquired resistance to apoptosis-mediated cell death. Therefore, simultaneous induction of other forms of cell death in addition to apoptosis of cancer cells is becoming an attractive strategy. For this purpose, we initially explored the role of XIAP in caspase-dependent and caspase-independent mechanisms of cell death. Our western blot data revealed that RIPK3 and MLKL levels were significantly elevated in MCF-7 cells following SAHA treatment. During induction of SAHA-induced cell death, the XIAP levels were …

The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig

Undergraduate Student Symposium

Treatment for osteoarthritis (OA) is primarily aimed at symptom management and is generally limited with emphasis placed on therapy and drugs such as NSAIDs, opioids, and acetaminophen. However, these drugs pose health risks for long-term use including contraindications, gastrointestinal, and cardiovascular issues. Thus, this systematic review of literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, on reducing the progression of OA when utilized on both a short-term and long-term basis. After evaluating the content of several scholarly journals, it was found that turmeric and ginger can aid in symptom management of OA and promote …

Global Education In Stem And Healthcare: Implications Of Covid-19, Jessica Hallet, Santanu De

Biology Faculty Articles

The Coronavirus Infectious Disease 2019 (COVID-19) was declared a pandemic in March of 2020. Since then, most schools, colleges, and universities across the globe stopped delivering classes face-to-face and transitioned into virtual modalities of instruction. This reformation of academics has had an impact on every field of study, especially those students in the areas of Science, Technology, Engineering, and Mathematics (STEM), and in the realm of healthcare education. Ranging from middle/high school to undergraduate and graduate programs, STEM degrees require intensive curricula integrating extensive lectures on theoretical topics and laboratory exercises to apply those concepts in a practical setting. Likewise, …

Developing A Sexual Health Consent Strategy For Refugees: A Qualitative Approach, Amita Tuteja, Elisha Riggs, Lena Sanci, Lester Mascarenhas, Anna Power, Di Vanvliet, Katrina Sangster, Kimberley Mcguinness, Meredith Temple-Smith

The Qualitative Report

We report the development of a strategy for obtaining a truly voluntary and informed consent for sexual and reproductive health (SRH) research with Burma-born refugees settled in Australia. Using a qualitative descriptive research design, we interviewed 29 providers of refugee services (PRS) including health care professionals (doctors, nurses, midwives), bilingual supporting staff (interpreters, social workers, settlement workers, community liaison officers) and administrative staff (practice managers, reception staff) who provide primary care services to refugees. Interviews were audio recorded, transcribed, and subjected to thematic analysis. Four themes emerged: (a) unique values of Burma-born people, (b) unfamiliarity with Western concepts of research, …

Repertorio Estético-Afectivo De Hombres Anti-Patriarcales: La Construcción De Otras Masculinidades, Jorge A. Jimenez Rodas, Juan C. Arboleda-Ariza, Milton D. Morales Herrera

The Qualitative Report

Los estudios de género en hombres y masculinidades retoman las bases de la crítica feminista para analizar los procesos y subjetividades masculinas. Este proceso ha estado acompañado de la creación cada vez más visible de colectivos de hombres que se oponen a los marcos hegemónicos de la masculinidad y promueven, por medio de un activismo político, versiones alternativas de entender lo masculino. En este trabajo nos preguntamos por el discurso que utilizan estos hombres y las consecuencias de este. Para esto analizamos el discurso de doce hombres latinoamericanos que participan en estos grupos e identificamos a partir de la variabilidad …

Attitudes And Usage Of Face Masks During The Covid-19 Pandemic Among Occupational Therapy Professionals In Texas, Stephen A. Cage, Diane P. Brown, Brandon J. Warner, Diana M. Gallegos, Heidi M. Cage

Internet Journal of Allied Health Sciences and Practice

Purpose: Following the widespread transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple business and schools drastically reduced face-to-face services. Additionally, many state and local governments enacted face mask mandates and other legislations aimed at decreasing the spread of the virus. Current research is being conducted to evaluate the epidemiology, recognition, treatment, and prevention of coronavirus disease 2019 (COVID-19), the disease associated with SARS-CoV-2. At the time of this study, there is no published research on the attitudes and usage of face masks or face coverings among certified occupational therapy professionals during the COVID-19 Pandemic. The purpose of this …

Phage Hunters: The Discovery Of Two Novel Bacteriophages That Infect Gordonia Rubripertincta, Sarah Ballarin, Neel Balusa, Melissa Bell, Samia Caballero, Joshua Chan, Maria Farez, Ashley J. Guillen-Tapia, Nashrah Pierre-Louis, Victoria Polishuk, Bhavya Soni, Julie Torruellas Garcia, Katie E. Crump

Sea-Phages

Antibiotic resistance is a global healthcare concern because it poses a threat to effectively treating bacterial infections and the need for alternative therapeutics are urgently required. Phage therapy, which uses viruses to treat bacterial infections, is a promising alternative to conventional antibiotics. Phages have also been widely used in the food industry to prevent microbial growth on certain foods and are currently being explored as a method for bioremediation of oil spills and wastewater treatment. Although phages are ubiquitous in nature, many have yet to be discovered. Through the SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) program …

Covid-19, Workplace Mental Health, And The Ada "Regarded As" Prong: A Hypothetical Case Study, Matthew Saleh, Jacquelyn Thomas, Susanne Bruyere, Hannah Potter, Sarah Jane Smith

Nova Law Review

No abstract provided.

On Florida Law, Language, And Alcohol Use Disorder, Stacey A. Tovino

Nova Law Review

No abstract provided.

Nova Law Review Full Issue Volume 46, Issue 3

Nova Law Review

No abstract provided.

Using Theraputic Jurisprudence To Improve Nursing Home Regulation During Future Pandemics, Kathy L. Cerminara, Alina M. Perez, Alexandra Kirby

Nova Law Review

No abstract provided.

Sodium-Glucose Transport Protein 2 (Sglt2) Inhibitors, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar

HPD Articles

No abstract provided.

Summer - Fall 2022, Nova Southeastern University

KPCOM SGA Rounds

No abstract provided.

Tsunami: Recommitting To Adress Aapi Mental Health In A Post-Covid Era, Oliver J. Kim

Nova Law Review

No abstract provided.

Impacts Of Covid-19 On Global Healthcare Management And Research, Stephanie Autore, Santanu De

Biology Faculty Articles

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic has affected most nations at all levels of functioning, individual to governmental. Therefore, it is imperative to evaluate the effects the virus has had on one of the most important socioeconomic global sectors, healthcare. This literature review explores key, recent research and management strategies that have been undertaken in healthcare systems around the world in order to make meaningful attempts at identifying the etiology, diagnosis, and treatment of the disease, and combating the spread of this deadly virus. Healthcare facilities have implemented a variety of changes, all geared towards reducing non-emergency patient visits …

Recognizing And Addressing Conflict That Emerges From Sociotechnical Change In Higher Education, Kathleen Ann Watkins-Richardson

Department of Conflict Resolution Studies Theses and Dissertations

Today’s unprecedented technology growth impacts at many levels—from individuals to groups to society. This study aims to characterize how exponential digital technology growth and organizational change is explained and experienced in a university setting deploying new instructional technologies—and how or where conflict emerges. Organizational conflict is a phenomenon that takes many forms and may not be fully recognized. This dissertation highlights theories of technology invention and disruption, the dynamics of sociotechnical change (defined as the interdependencies between people, technology, and the environment) and response in organizations, complex adaptive systems, and practice theory of change. It considers current technological forces at …

Nsu College Of Psychology Graduate Student Catalog 2022–2023, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Psychiatric And Neuropsychological Sequelae Of Herpes Simplex Encephalitis, Carla F. Cabrera, Charles J. Golden

Archives of Assessment Psychology

Herpes simplex encephalitis (HSE) is caused by the herpes simplex virus (HSV), often from the Type 1 (HSV-1) viral infection. This neurotropic double-stranded DNA virus impairs the integrity and permeability of the blood-brain barrier, allowing the virus to enter the brain. In several studies, HSV-1 impacts the temporal lobe, frontal lobe, and limbic system, leading to brain damage. While significant progress has occurred in understanding this infection, clinicians should be vigilant for acute and chronic complications associated with HSE, such as autoimmune encephalitis, differential diagnoses, and psychological disorders. A growing body of literature focuses on the evidence of an association …

Teaching And Assessing College Stem Courses Online During Covid-19: Evidence-Based Strategies And Recommendations, Santanu De, Georgina Arguello

FDLA Journal

Since the devastating COVID-19 pandemic, most schools, colleges, and universities worldwide underwent a paradigm shift by transitioning to digital teaching and learning modalities. This phenomenon was essential to mitigate the contagion; however, the academic institutions needed to quickly come up with ways to ensure that the quality and rigor of education were maintained, especially the active and experiential learning required by undergraduate and graduate courses in science, technology, engineering, and mathematics (STEM). This paper highlights key approaches reported or proposed to effectively conduct college-level, in-person STEM courses online owing to the pandemic. These would range from synchronous versus asynchronous pedagogies …

Challenges Among Children During Three Phases Of Covid-19 In Pakistan, Sana Rehman

The Qualitative Report

Children are not indifferent to mental health issues in response to COVID-19 and experienced surge of challenges. Therefore, in the current study children of 8 to 16 years were recruited to investigate the challenges and its impact on children mental health during all three phases of COVID-19. The Colaizzi’s phenomenological method for qualitative analysis was used to investigate the student’s response. The reactions of students were summarized into three themes and sixteen sub-themes considering all three phases of COVID-19. The three major themes are religious concerns, mental health issues, and academic concerns. The findings have been discussed in terms of …

Exploring The Effectiveness Of Robotic Exoskeletons In The Acute Care Phase Of Acquired Brain Injury Rehabilitation, Renee E. Brooks

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.