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Periodic Spatial Disturbances Alter The Expression Of Quorum Sensing Virulence Factors In Pseudomonas Aeruginosa, Laura García-Diéguez

All HCAS Student Capstones, Theses, and Dissertations

Pseudomonas aeruginosa is an opportunistic pathogen associated with severe acute and chronic illnesses. Current antibiotic-based approaches fail to effectively treat P. aeruginosa infections due to the effectiveness and robustness of the quorum sensing signaling system (QS). Pathogenic bacteria, such as P. aeruginosa, employ this population density-dependent communication mechanism to confer antimicrobial resistance, propagate infection, and coordinate the expression of virulence factors, through the production and detection of autoinducing signaling molecules (AI). As such, there is a growing interest in developing novel non-antibiotic-based techniques to attenuate the pathogenicity of P. aeruginosa by disrupting the functionality of its QS system. Previous …

A Novel Tcr Clustering Method For Sars-Cov-2 Epitopes, Naziba A. Nuha

Mathematics Colloquium Series

T-cell epitopes are peptides generated from antigens that are presented by MHC class I and class II molecules to T-cells. These epitopes are usually identified by T-cell receptors (TCRs) of CD4 T-cells which then causes transformation of CD4 T-cells to helper or regulatory T cells. Recently, there has been growing interest in the role of T cells and their involvement in various ailments including SARS-COV-2, cancer, autoimmune diseases and other infectious diseases. However, the mechanism of TCR epitope recognition by Tcell receptors (TCRs) of CD4 T-cells at a repertoire level is still not fully understood. In this project, we reviewed …

A Weighted Probability Measure For Objects In Euclidean Space, Alessandro Xello

Mathematics Colloquium Series

Since we were little kids, we developed our own sense dimension as a measure of some kind of extent. Whether it be length, width, or height, we intuitively understand how these features fit in the three-dimensional world we live in, and how to measure it. Nevertheless, mathematicians have found themselves dealing with objects, like fractals, and spaces, like R4 , that challenge our intuitive and self-developed definition of measure, to the point that it is not sufficient anymore. Lebesgue measure and Harsdorf measure for example are ways of assigning a measure to objects that belong to n-dimensional Euclidean spaces, in …

Baseline Health And Nutritional Parameters Of Wild Sand Tigers Carcharias Taurus Sampled In Delaware Bay, Lisa A. Hoopes, Tonya M. Clauss, Bradley M. Wetherbee, Dewayne A. Fox

Marine & Environmental Sciences Faculty Articles

Species-specific hematological reference values are essential for diagnosis and treatment of disease and maintaining overall health of animals. This information is lacking for many species of elasmobranchs maintained in zoos and aquaria, thus reducing the effectiveness of care for these animals. Descriptive statistics and reference intervals were calculated for hematocrit and complete blood cell counts, biochemistry and protein electrophoresis parameters, trace minerals, vitamins, heavy metals, reproductive hormones, and fatty acids in the blood of 153 wild Sand Tigers Carcharias taurus of both sexes and a range of sizes caught in Delaware Bay (Delaware, USA). Mean hematocrit, total white blood cell …

A Computational Analysis Of Structural Analogs Of Colchicineas Potential Microtubule Polymerization Inhibitors, Isadora Rocha De Abreu, Allison Barkdull

Undergraduate Student Symposium

Microtubules are structures important for cell survival and cell function. They are responsible for the formation of the cytoskeleton and mitotic spindles, they aid in cell movement, intracellular transport, amongst other functions. Microtubules are composed of the tubulin protein made of alpha-beta dimer proteins. During polymerization tubulin proteins experience phases of dynamic instability, characterized by microtubule growth and shrinkage at varying rates. Microtubule growth can be inhibited by compounds such as colchicine, a known microtubule destabilizing agent, that binds to tubulin inhibiting microtubule polymerization. Colchicine has limited clinical use due to its toxicity and low solubility. In this study we …

A Mathematical And Ergonomic Analysis Of Fundamental Laparoscopic Surgery Tools And Techniques, Joshua Bennett, Anneleissa Lugay, Daniel Celestino, Paula Veras

Undergraduate Student Symposium

Laparoscopic surgery is a means to perform procedures in a minimally invasive manner. For surgeons, this requires further training due to increased complexity and fatigue. The goal of these experiments was to study the ergonomics of laparoscopic tools and the physical and cognitive requirements of the Fundamentals of Laparoscopic Surgery (FLS) tasks.

Surface electromyography (sEMG) was used to measure muscle fatigue on the left and right trapezius and electroencephalogram (EEG) was used to record brain waves of the participants. The percent maximum voluntary contraction (%MVC) concept was used to measure fatigue levels. Mean power spectral density was used to categorize …

A Novel Tcr Clustering Method For Sars-Cov-2 Epitopes, Naziba Akther Nuha

Undergraduate Student Symposium

T-cell epitopes are peptides generated from antigens that are presented by MHC class I and class II molecules to T-cells. These epitopes are usually identified by T-cell receptors (TCRs) of CD4 T-cells which then causes transformation of CD4 T-cells to helper or regulatory T cells. In this project, we look at the different TCR sequences of the same length that are activated by two different epitopes for the SARS-COV-2. Building on previous work using Principal component analysis to analyze twenty different physiochemical properties of amino acids, we convert the amino acids in the TCR sequences to numerical strings. We then …

An Episodic Study Of Hospital Charges For Hospital Admissions And Readmissions In 2017 In The United States For Degenerative Nerve Systems Disorders (Drg = 056), Esha Sultana

Undergraduate Student Symposium

Understanding hospital charges upon admission as well as readmissions is critical for value-based care. The extant literature focuses on patient-specific, disease-specific, and hospital-specific factors to explain the variance in hospital charges across the United States. Studies have mainly examined hospital charges upon admissions but there has been lack of empirical research on examining hospital charges upon readmissions. This has resulted in ambiguity in understanding the primary determinants of hospital charges upon readmissions. To address this gap, the federal agency AHRQ developed the HCUP hospital readmissions database that produces nationally representative information about hospital readmissions. This study utilizes the AHRQ 2017 …

Analysis Of Errors In Ecgs Data Captured By Patients Using At-Home Device Compared To Qualified Healthcare Professionals, Colin Pulickathadam

Undergraduate Student Symposium

Cardiovascular Diseases (CVDs) are a leading cause of death worldwide, accounting for 17.3 million deaths per year. General at-home care has been proven to improve patient outcomes and decrease hospitalization rates. The purpose of this presentation is to present preliminary results from a research study comparing the electrocardiograms (ECG) readability from patients and their caregivers, who conducted at-home ECGs in the experimental group, versus data on ECG readability from patients living in assisted living, nursing home facilities, and routine office visits, where a qualified healthcare professional takes the ECG readings as the control group. This research study will also evaluate …

Benefits Of Stem Mentorship: Introducing Microbiology Research To High School Students, Tassnime Sebaei, Katrina Maktaz, Varsha Chigurupati

Undergraduate Student Symposium

Bacteria Unearthed is an NSU initiative to bring together high school and college students to participate in Tiny Earth: an international consortia of researchers searching for novel microorganisms and antibiotics to combat antibiotic drug resistance. Our group developed a STEM mentor program as a catalyst for students to significantly increase academic performance. The program allows high schoolers to become part of the global research community. These high school students enrolled in their microbiology classes are supported by undergraduate students who have experience working with Tiny Earth. Through this experiential learning, it is expected that there will be improvements in …

Bilinguals Demonstrate Stronger Inhibitory Response Bias In Tasks Of Executive Function, Samruddhi Ayachit, Erika Cabrera Ranaldi

Undergraduate Student Symposium

From switching from one task to another or quickly memorizing a number to call, people use executive function daily. Executive function is thought to be controlled by frontal lobe inhibitory processes. Reportedly, people who speak more than one language also use the same frontal lobe processes to switch between languages. It is therefore believed that these inhibitory processes are more prominent in bilinguals because of the experience of controlling multiple languages. To test this theory, bilinguals and monolinguals were compared on executive function tasks. Participants were matched on demographic variables and fluid intelligence. To examine inhibition, participants were tested with …

Bioremediation Of Algae-Based Water Treatment: Analysis Of Algae Adsorption Of Heavy Metals Based On Ion Size And Covalent Indices, Samir Sakaria, Rebecca Mathew, Amelia Figueroa

Undergraduate Student Symposium

A previous published study completed at Nova Southeastern University determined that Neochloris alveolaris and Neochloris minuta algal strains which were grown in nitrogen-rich (+N) and nitrogen-depleted (-N) environments biosorbed Pb²⁺, Cd²⁺, Zn²⁺, Cu²⁺, and Ni²⁺ at varying concentrations. These algae biosorbed each metal differently based on their biomass composition (carbohydrates, fats, and lipids) and the type of hard or soft metal acids available, according to the Pearson theory of Hard Soft Acid Base (HSAB) definition. Given these promising findings, this study aimed to further analyze and determine the effect of hard …

Can Statins Mitigate Adverse Effects Of Hormone Replacement Therapy In Women?, Adhm Farid

Undergraduate Student Symposium

Heart disease is the leading cause of death for women in the United States. One possible overlooked risk factor for heart disease in women is hormone replacement therapy(HRT). HRT is most often used to treat certain kinds of breast cancer that depend on sex hormones to grow or to supplement estrogen to women over 60 or who have had a hysterectomy. HRT has been found to increase levels of C-reactive protein(CRP), which is the bio-inflammatory marker that best predicts cardiovascular risk. Statin therapy has been found to decrease levels of C-reactive protein. Currently, CRP is not taken into consideration when …

Caribbean Reef-Building Coral-Symbiodiniaceae Network: Identifying Symbioses Critical For System Stability In A Changing Climate, Mackenzie Magyar, Brady Estrada, Timothy Swain Ph.D.

Undergraduate Student Symposium

Coral reef bleaching events across the globe are increasing following intensifying marine heatwaves and higher ocean temperatures. The frequency and intensity of bleaching events are expected to rise over the next 100 years. An increase in coral mortality has been observed in the Caribbean between 1970-2012. Our objective is to produce a network of all Caribbean hermatypic coral-Symbiodiniaceae associations and analyze it in the context of increased temperatures and coral bleaching events. The available scientific literature was explored and inspected to evaluate whether these papers included relevant data for building the network, including the coral host, host depth, sample location, …

Deficits In Gait Biomechanics In Runners On A University Team: Implications For Preventative Sport Healthcare, W. Zachary Dean

Undergraduate Student Symposium

Sport healthcare providers in team-based settings conduct functional testing to identify injury risk. Results are used in team-based injury prevention programs. This process is different than care for a patient once they become injured. Gait analyses are a functional test for runners. Therefore, we aimed to describe the bilateral running biomechanics in a university cross country team with emphasis on variables linked to running-related injury (RRI). Twenty-seven male (n=10) and female (n=17) distance runners (age, 18-23yrs; height, 1.82±0.57m; mass, 58.4±6.8 kg) from a single university team participated in this descriptive study. Gait was assessed during a treadmill run at a …

Determinants Of Hospital Charges For Hospital Admissions And Readmissions In 2017 In The United States For Bronchitis And Asthma With Complications And Comorbidities (Drg = 202), Japjot Singh

Undergraduate Student Symposium

Understanding hospital charges in the U.S. healthcare system is vital for value-based care, recovery, and socio-economic wellbeing of the public. Hospital charges vary across hospitals regionally as well as nationally. As per the clinical history of hospital in-patient care, there are several determinants of hospital charges that are specific to the patient, disease, hospital, or the chargemaster. Empirical research on hospital in-patient care has bolstered the extant knowledge on the factors that determine the healthcare cost and utilization, but research is limited on how hospital readmissions impact hospital charges. The Agency for Healthcare Research and Quality (AHRQ) has developed a …

Effect Of Gamma Irradiation On Vitamin D Stability In Salmon, Varun Natarajan

Undergraduate Student Symposium

Salmon and other finfish are one of the major dietary sources of vitamin D. However, the presence of pathogenic bacteria, such as vibrio sp and listeria sp, can lead to foodborne illnesses. In 2015, 18% of foodborne illnesses were attributed to finfish. Gamma irradiation can serve as an effective tool to minimize bioburden and thereby decrease the risk of foodborne illnesses. While gamma irradiation has been used on other types of food, including chicken and crustaceans, its effects on fresh finfish has not been studied. This project examines the effect of low dose gamma irradiation on the stability of vitamin …

Effect Of Periodontitis On Inducing Late Onset Alzheimer's Disease (Load) Pathology In Mice, Neha Gupta, Courtney Mai, Miguel Cuello

Undergraduate Student Symposium

Alzheimer’s disease is the most common form of dementia; affecting approximately 50 million people worldwide. Recent evidence indicates poor dental hygiene may accelerate Alzheimer’s degeneration. Experimenters used a mouse model of periodontitis induced by P. gingivalis and investigated the implications of poor dental health on Alzheimer’s Disease and neuroinflammation, as well as memory skills, in relation to aging, gender, and condition. All the mice in the model were the same age, and a total of 8 mice with Alzheimer’s Disease and 8 mice who had Alzheimer’s Disease with inflammation with an equivalent number of males and females were utilized. Experimenters …

Effects Of Water Hyacinth Management On Fish Populations, Sara Schutt, Mary Hill, Melanie Vasquez

Undergraduate Student Symposium

Invasive water hyacinth (Eichhornia crassipes) creates significant economic and ecological problems in Florida. Removal of this invader cost an estimated $4.19 million in the 2020 fiscal year. Water hyacinth has also been shown to alter water quality and chemistry and reduce fish populations. Current management strategies involve manual removal and the application of herbicide. New methods, including biological control, are being investigated to improve the efficiency of current management methods. Questions about the effects of these novel management strategies have emerged, including the response of fish populations to the new treatments. To answer these questions, we set up …

Emotional Resilience Of The Covid-19 Pandemic On A College Campus, Jenna Binaco

Undergraduate Student Symposium

The perceptions of people during the Covid-19 pandemic cannot always be true. This is due to a life of uncertainty and for many people, fear. Since the pandemic has been around for about two years, this is an excellent opportunity to see how this pandemic has impacted people’s mental health. A way that this information can be recorded is with The Emotional Resilience scale of the Covid-19 Pandemic on a College Campus. Emotional resilience was measured in 1704 American university students, staff, and faculty in October to November 2021 of the Covid-19 pandemic. This was a transitional period for people …

Examining The Impact Of Mind Wandering On Task Performance: Does Task Difficulty Matter?, Kortne Bajor, Jozef Cruz, Amulya Chowd Koritala, Gargee Pandya

Undergraduate Student Symposium

Mind wandering is a phenomenon in which an individual’s thoughts drift from the current task to a task unrelated thought (TUT). It is known to be affected by various factors such as state of mind, neuroticism, and boredom which may differ for each individual. Task difficulty appears to impact mind wandering rates, such that mind wandering increases on tasks with lower difficulty (Seli et al., 2018). However, prior work has not examined how emotionally valenced mind wandering impact task performance at different levels of task difficulty. Mind wandering typically predicts poorer ongoing task performance (McVay & Kane, 2010) and negatively …

Exploring The Prevalence Of Carpal Tunnel Syndrome (Cts) Symptoms In College Students, Kyrah Maduro

Undergraduate Student Symposium

Carpal tunnel syndrome (CTS) causes functional impairments and is prevalent in occupations involving repetitive hand movements. Given the extensive use of electronic devices for coursework, college students may be at risk for CTS. The purpose of this study was twofold: to examine the symptomology of CTS in college students, and to determine treatment strategies used by occupational therapists (OT) who treat college students with CTS. We developed and administered a 17-question College Student CTS Experiences Survey for students. Participants were recruited via flyers posted on a university campus. Inclusion criteria for responding included being a college student experiencing pain, tingling, …

Firearm-Related Injuries Rates From 2014 To 2017 Among Floridian Children, Joel Marlapudi

Undergraduate Student Symposium

Purpose: To assess the prevalence of firearm-related injuries among pediatric patients in Florida by age, race, and ethnicity.

Method: The dataset from the Florida’s Agency for Health Care Administration from 2014-2017 was utilized for this analysis as well as the Florida Community Health Assessment and Resource Tool Set. The study included ambulatory ED-visits of Floridian patients (aged ≤ 19 years) who had firearm-related Principal Diagnosis coded using the International Classification of Diseases. Patients who reported race as White or Black and Ethnicity as Hispanic or non-Hispanics were included. Patients’ county was categorized into 11 regions defined by Florida Local Health …

Gadra's Allegory, Bianca Vucetich

Undergraduate Student Symposium

“Gadra’s Allegory” is a silent (with no dialogue, but music is utilized) short film that follows a modern day ‘prisoner’ who exemplifies how their society is chained to the screens that surrounds them. The film shows their journey from a repetitive, thoughtless, and disillusioned way of life, to a majestic awakening to the nature of reality. This film is based on and inspired by Plato’s “Allegory of the Cave,”; though the main character of the film is based off the chained prisoner of the allegory, this alternate version shows another path to their own enlightenment and expresses their own internal …

Great Plains Midcontinental Loess Deposits Following Prehistoric Megadroughts And Climate-Change Related Ecosystem Collapse In The Badlands, Melanie Vasquez, Drew Tozer, Catherine Acosta

Undergraduate Student Symposium

Understanding effects of prehistoric extreme climate events on the environment is necessary to help predict effects of modern global climate change. Research shows prehistoric megadroughts caused the collapse of North American grassland ecosystems, allowing wind to erode soils and fined-grained sediment. Timing, severity, and regional extent of these megadroughts remain controversial, but research indicates at least three megadrought periods on the North American midcontinent over the last 20,000 years. Evidence for prehistoric megadroughts is preserved in dune fields and loess deposits throughout the North American Great Plains, including our field area in the Badlands of South Dakota. Loess, composed of …

Ha Ha Ha... Good One!... Not You Hmongs. Laughter, White Privilege, And "Othering" In Medical Cultures, Sarah Soliman

Undergraduate Student Symposium

The response to alternative medical approaches of underprivileged and underrepresented groups detailed by Anne Fadiman differ from the hegemonic alternative approaches exemplified by Norman Cousins. In The Spirit Catches You and You Fall Down, Fadiman describes the inadequate efforts made by healthcare professionals to communicate with the Lee family who did not understand English and had significantly different medicinal practices from Western biomedical practices. Rather than being met with respect and attentiveness, these medical professionals viewed this family as “difficult” and “stupid.” In comparison to the various mistreated groups of minorities, the Hmong are a minority within the minority …

Human Mtdna Copy Number Quantification, Leonardo Lacayo, Luzcarime Saco-Vertiz

Undergraduate Student Symposium

Our social worlds and physical health are profoundly intertwined, but we have limited tools for studying these important connections. Within the recent psychiatric literature, changes in mitochondrial DNA copy number (mtDNAcn) have been linked to a variety of socially influenced mental illnesses such as major depression. In principle, this biomarker may therefore also be responsive to more subtle changes in our social environments, including life events that attenuate stress.

This poster outlines plans for a novel molecular study of how interspecies social bonding impacts human cells. Specifically, we propose to use quantitative PCR to measure the abundances of (single copy) …

I Can Hear You, I Just Can't Remember You: Deconstructing The Sensory And Cognitive Components Of Hearing Loss, Pranay Narang, Hana Amireh

Undergraduate Student Symposium

Hearing loss is commonly thought of as solely a sensory, not cognitive, problem. According to the effortfulness effect, however, those with presbycusis are burdened with an increased attentional cost for auditory processing, taxing the central executive such that working memory is impaired. The excess strain placed on the central executive to decode sensory noise ultimately impairs one’s capacity to attend to and consolidate memories, compromising retention. We hypothesize that the presence of white noise during encoding will mimic the effect of hearing loss sustained in older adults and will impair the retrieval of auditory information in those with normal hearing. …

Implications Of Covid-19 For Education And Research In Healthcare And Stem: Analysis Of Global Case Studies, Yumna Indorewala

Undergraduate Student Symposium

The novel coronavirus, SARS-CoV-2 has posed a major threat to global education and research in STEM and healthcare. Social distancing guidelines were initially recommended to refrain from face-to-face operations for preventing the transmission of the virus. As schools and higher academic institutions implemented multifarious methods to effectively transition to remote/online or hybrid educational formats, the Coronavirus Infectious Disease 2019 (COVID-19) pandemic introduced further hurdles and necessitated designing, adopting, as well as evaluating the efficacy of new instructional approaches, especially for disciplines that require active, experiential learning such as healthcare and STEM. These effects are accentuated in less developed/developing nations or …

Inter-Limb Kinetic Asymmetries Differ Between Concentric And Eccentric Phases Of The Vertical Jump, Vanessa Alexandre

Undergraduate Student Symposium

Inter-limb asymmetries during the vertical jump (VJ) have been used to identify injury risk and performance deficits with >10% being a threshold. Force, or kinetic asymmetries have typically been studied for the concentric (propulsive) phase of the VJ while eccentric (loading) phase analyses are limited. The purpose of this study was to determine if there were differences in inter-limb asymmetry (%) in impulse (force * time) and peak force between VJ eccentric and concentric phases. Results may inform coaches and sport healthcare providers. Participants were 60 highly skilled males (age, 22.7±1.1yrs.; height, 186.4±6.8cm; mass, 103±21.2kg) undergoing training for the National …