Digital Commons Network^™

Direct Phenotypic Screening In Mice: Identification Of Individual, Novel Antinociceptive Compounds From A Library Of 734 821 Pyrrolidine Bis-Piperazines, Richard A. Houghten, Michelle L. Ganno, Jay P. Mclaughlin, Colette T. Dooley, Shainnel O. Eans Torrey Pines Institute For Molecular Studies, Radleigh Santos, Travis Lavoi, Adel Nefzi, Greg Welmaker, Marc A. Giulianotti, Lawrence Toll

Mathematics Faculty Articles

The hypothesis in the current study is that the simultaneous direct in vivo testing of thousands to millions of systematically arranged mixture-based libraries will facilitate the identification of enhanced individual compounds. Individual compounds identified from such libraries may have increased specificity and decreased side effects early in the discovery phase. Testing began by screening ten diverse scaffolds as single mixtures (ranging from 17 340 to 4 879 681 compounds) for analgesia directly in the mouse tail withdrawal model. The “all X” mixture representing the library TPI-1954 was found to produce significant antinociception and lacked respiratory depression and hyperlocomotor effects using …

A Comparison Of Infaunal Community Structure Between Pre- And Post Construction Sampling Of Artificial Fdot Rock- Pile Reefs In Broward County, Florida, Joan Lorraine Guerra

HCNSO Student Theses and Dissertations

Artificial reefs (ARs) are generally created with the intention of increasing local fish populations, biodiversity and corresponding habitat productivity, most often in support of commercial and recreational uses (e.g., diving and fishing). Numerous studies have investigated the communities that develop on artificial reefs. By contrast, far less research has focused on the surrounding infaunal communities, which represent critical trophic resources for many species that populate both natural and artificial reefs, and which may be affected both by AR deployment and the organisms that subsequently recruit to them. This study compared infaunal organism abundances at four sites between the inner and …

Feeding Ecology Of The Invasive Lionfish (Pterois Spp.) And Comparison With Two Native Species: Schoolmaster Lutjanus Apodus (Walbaum, 1792) And Graysby Cephalopholis Cruentata (Lacepède, 1802), Jesse J. Secord

HCNSO Student Theses and Dissertations

Predator satiation and prey-size preference were determined for locally caught lionfish, schoolmaster, and graysby, all co-occurring predatory fishes in the Florida coral reef ecosystem. Individuals were evaluated by exposing them to wild-caught killifish over a gradient of four size classes (20 mm to 60 mm, in 10 mm increments). Preference trials extended over a 2 hr time period and were filmed to determine the order in which each prey item was consumed. Satiation was evaluated by exposing the predators to an equal number of excess prey items for 24 hrs and evaluating consumed prey weight. Lionfish and schoolmaster showed a …

The Effects Of Petroleum Pollutants On Sea Urchins Reproduction And Development, Kellie C. Pelikan

HCNSO Student Theses and Dissertations

Disturbances, such as mass pollution events, threaten the health of vulnerable ecosystems. Recent media attention has focused on the devastating mass oil spills, but daily petroleum input from recreational and commercial ship bilge release has been overlooked. The focus of this study was the effect of petroleum products found in bilge water on fertilization success and larval viability of two sea urchin species, Lytechinus variegatus and Eucidaris tribuloides. Unlike other pollutant studies that have focused on sperm characteristics and concentrations, I chose to examine how egg integrity was compromised by petroleum products. Scanning electron microscopy revealed eggs were degraded when …

Holding Death At Bay Vs. Prolonging Life: Indexing Fatalism And Optimism In The Ideology Of Health, Genetics, And Family History In The U. S. And South Korean Media, Soo Jung Hong, Susan Strauss

The Qualitative Report

Media discourse creates and shapes views of personhood, of possibilities, of wellness, and at the same time, these views and beliefs, in their turn, shape media discourse. Broadcasts of health-related edutainment programs and advertisements are rich sources for the discovery of stances concerning health and illness. We examine media discourse in the United States and South Korea, and uncover consistent indexical patterns pointing to overall ideologies of fatalism in the U.S. and optimism in South Korea. Specifically, from an indexicality-based perspective, we identify the patterned ways in which the ideologies of fatalism and optimism are indexed with regard to agency …

Applying A Socio-Ecological Framework To Thematic Analysis Using A Statewide Assessment Of Disproportionate Minority Contact In The United States, Dawn X. Henderson, Tiffany Baffour

The Qualitative Report

Disproportionate minority contact (DMC) in the United States represents a critical social challenge to promoting the ideals and values of social justice. The ecological nature of DMC, a phenomenon emerging from the intersection of micro- and macro-level factors, necessitates the application of systems theories in understanding the issue and designing solutions to address it. This article illustrates the application of socio-ecological systems theory in thematic analysis, drawing associations across multiple systems between contributing factors to DMC in the juvenile justice system in North Carolina, USA. Analysis examined data from 6 focus groups comprised of 55 statewide stakeholders involved in the …

Habitat Utilization And Vertical Distribution Of The Great Barracuda Sphyraena Barracuda (Edwards 1771) In The Western North Atlantic Using Electronic Archival Tags, Noah R. Hansen, David W. Kerstetter

Marine & Environmental Sciences Faculty Articles

The Great Barracuda Sphyraena barracuda is a large predatory teleost commonly seen in the tropics of the Western North Atlantic. Using pop-up satellite archival tags (PSATs), two large Great Barracuda (101 and 104 cm FL) were tagged off South Florida for a 15-day deployment period. Great Barracuda 88094 traveled 471 km minimum straight-line distance (MSLD) over the deployment duration, while Great Barracuda 88095 traveled 1231 km MSLD. Great barracuda 88094 achieved a maximum depth of 145.2 m, while 88095 to a maximum depth of 186.9 m, although such movements were for short time durations. The data obtained indicate significant differences …

The Current Volume 26 : Issue 14, Nova Southeastern University

Student Newspapers

No abstract provided.

Humeral Retrotorsion In Developing Children And Its Relationship To Throwing Sports, Elliot M. Greenberg

Department of Physical Therapy Student Theses, Dissertations and Capstones

Background: Baseball players exhibit a more posteriorly oriented humeral head or humeral retrotorsion (HRT) in the dominant arm, likely representing an adaptive response to the stress of throwing. This adaptation is thought to occur while skeletally immature, however there is limited research detailing how throwing while young influences the development HRT. In addition, it is currently unclear how this changing osseous orientation influences shoulder motion within young athletes. Purpose: To determine the influence of throwing and age on the development of asymmetry in HRT and shoulder range of motion (ROM); and analyze the relationship between HRT and ROM. Study Design: …

Assessing Orthodontic-Bracket Impacts On Lip Profile At Bonding And Debonding Stages, Martin Trockel

Student Theses, Dissertations and Capstones

Introduction: One factor that contributes greatly to the lower face appearance and orthodontists have the ability to affect is lip profile. Clinical assessment of the lip profile is an important element in the decision of orthodontic treatment planning and in the evaluation of treatment progress and outcome. Three known factors influence the lip profile; the lip thickness, the underlying bone, and the tooth position. The positions and inclinations of the anterior teeth can affect the lip position, but it is unclear whether orthodontic brackets bonded to the labial surface of anterior teeth move the lip position and thereafter change the …

Evaluation Of Frictional Forces Between Brackets Of Different Types At Various Angulations And An Arch Wire: With And Without Pulsating Vibration, Benjamin M. Christman

Student Theses, Dissertations and Capstones

Objective: The objective of this study was to determine the effect of pulsating vibration on the sliding resistance between orthodontic brackets and stainless steel wires. Brackets were placed at two different angulations (0° and 5°) to simulate leveling of a tipped tooth during tooth movement. Pulsating vibration was delivered via the AcceleDent device.

Background: Friction is defined as a force that retards or resists the relative motion of two objects in contact, and its direction is tangential to the common boundary of the two surfaces in contact. This has been of interest to the orthodontist since the mid-20th century. Since …

Effects Of Sodium Hypochlorite On Enamel Composition, Sonni Pellillo

Student Theses, Dissertations and Capstones

The purpose of this study was to evaluate the effects of sodium hypochlorite on the organic and inorganic composition of enamel. Background: With the advent of enamel bonding for orthodontic appliances in the late 1970s, it has been shown that traditional phosphoric acid etching affects the inorganic portion of the enamel.1, 2 In an attempt to enhance the acid etching pattern and, furthermore, the bond strength, additional pretreatment techniques that target the organic components of the enamel biofilm have been proposed. One such method is the non-invasive enamel pretreatment with 5.25% sodium hypochlorite (NaOCl) prior to phosphoric acid etching.3, 4 …

Starting Where You Are: How Race Can Constrain Researchers Within The Research Setting, Kamesha Spates, Wangari Gichiru

The Qualitative Report

What challenges can race and gender present for researchers of color? As Black women, we draw on personal reflections to look back at our graduate training and its influence on how we conducted ourselves in the field as graduate students and now as researchers in the academy. We particularly consider how mainstream pedagogical approaches to teaching qualitative methods might work to marginalize researchers of color throughout the qualitative research process. We lay out these complexities, not necessarily to offer solutions but rather to allow others in similar situations to think about their own journey as we collectively move qualitative research …

Hardships Of Scarcity: Microsociology On Poor People’S Survival Strategies In Everyday Life, Antonio Rosales

The Qualitative Report

Basic human rights are not met in many parts of the world. Hunger, ill-health, and poor education are often part of the lives of the poor. The purpose of this study is to understand poor people's sources of strength, social relations, sources of income, and perspectives as strategies to cope with poverty in everyday life. Data gathering was done through field observations and semi-structured interviews with poor and non-poor people in the Philippine town, Hagonoy. All data was codified according to recurrent and salient issues and analyzed using chiefly symbolic interactionism as the theoretical framework. The results of this study …

Importance Of The Student Therapist/Athlete Relationship And Goal-Setting In Injury Rehabilitation, Colin Deal, Chris A. Shields

The Qualitative Report

Previous research has highlighted the importance of relationships (e.g., athletic therapist/client) and psychological skill use to manage negative emotions (e.g., frustration, anger) in order to obtain optimal adherence and injury rehabilitation outcomes. However, the relationship between student athletic therapists and varsity athletes has not been examined. Thus, the objective was to examine the relationship between student therapists and varsity athletes and psychological skill use in injury rehabilitation in relation to adherence. Two senior student therapists and three varsity athletes who had completed injury rehabilitation were recruited to participate in semi-structured interviews. Transcripts were analysed using thematic analysis. Both groups of …

Engaging Young Fathers In Research Through Photo-Interviewing, Nicolette Sopcak, Maria Mayan, Berna J. Skrypnek

The Qualitative Report

Although conducting interviews is the most popular research strategy in qualitative research, we question whether it is the best strategy to use with young fathers and other populations who may be less willing to share personal experiences and thoughts with an unknown researcher. The reluctance of young fathers to engage in research leads to the omission of important perspectives and inadvertently results in young fathers' being understudied and unwittingly excluded from support programming and services. In this paper, we describe our experiences of using two different research strategies with young fathers: conventional in-depth interviews (i.e., interviews that rely on words …

Investigating The Role Of The Host Multidrug Resistance Associated Protein Transporter Family In Burkholderia Cepacia Complex Pathogenicity Using A Caenorhabditis Elegans Infection Model, Pietro Tedesco, Marco Visone, Ermenegilda Parrilli, Maria Luisa Tutino, Elena Perrin, Isabel Maida, Renato Fani, Francesco Ballestriero, Radleigh Santos, Clemencia Pinilla, Elia Di Schiavi, George Tegos, Donatella De Pascale

Mathematics Faculty Articles

This study investigated the relationship between host efflux system of the non-vertebrate nematode Caenorhabditis elegans and Burkholderia cepacia complex (Bcc) strain virulence. This is the first comprehensive effort to profile host-transporters within the context of Bcc infection. With this aim, two different toxicity tests were performed: a slow killing assay that monitors mortality of the host by intestinal colonization and a fast killing assay that assesses production of toxins. A Virulence Ranking scheme was defined, that expressed the toxicity of the Bcc panel members, based on the percentage of surviving worms. According to this ranking the 18 Bcc strains were …

A Comparison Of Macroinfaunal Community Structure Between Artificial Concrete Boulder Reefs And Adjacent Natural Reefs In Broward County, Florida, Amber C. Metallo

HCNSO Student Theses and Dissertations

Relatively little is known about either the biological (i.e., predation) or physical (i.e., current, sedimentation) effects that artificial reefs may have on surrounding benthic infaunal communities. Following deployment of artificial reefs (concrete boulders) between the first and second reefs off Fort Lauderdale, Florida, on 30 October 2009, sediment cores were taken at 4 distances along three replicate 10-m transects on 13 and 26 September 2013, and 24 and 25 May 2014 at each of four artificial reef sites and four of their adjacent natural reef sites using SCUBA. Infauna (>0.5mm) were extracted from the sediment and identified to the …

The Current Volume 26 : Issue 13, Nova Southeastern University

Student Newspapers

No abstract provided.

Cut From The Same Cloth: The Us Textile And Apparel Industry And Post-Disaster Designs For Haiti, Ransford Edwards Jr.

Humanities and Politics Faculty Articles

In the aftermath of the 2010 Haitian earthquake, various neoliberal strategies have been advanced to help in short-term disaster mitigation and reconstruction, as well as more long-term improvements in the country’s overall economic integration and growth. One such strategy has been focused on revitalizing the country’s apparel assembly industries through an aggressive expansion of export processing zones (EPZs). The disaster, it appears, represented an important opportunity to improve economic conditions by reorganizing the country’s role in the global apparel commodity chain. However, this reorganization conflicts with the preferences of US textile and apparel producers who have used trade preference programs …

Video: May It Please The Court: Techniques For Persuasive Witness Testimony, Mark Dobson, Jayme Cassidy, Maxine Streeter

NSU Law Seminar Series

Success at trial depends on preparation and practice. Knowing the law and the facts of the case is important. Knowing how to present persuasive witness testimony at trial and how to speak to the Court and jury in an ethical and professional manner is even more important. Learn techniques to prepare witnesses and yourself for successful handling of direct, cross-exam, and objections to achieve your goals at trial. Our panel will direct an interactive role-play session.

Species Specific Microcalcification In Reef Building Caribbean Corals In Ocean Acidification Conditions, Ashley M. Dungan

HCNSO Student Theses and Dissertations

Coral reefs are one of the most economically important ecosystems on the planet. Despite their great contribution to the world economy, anthropogenic influence via carbon dioxide emissions is leading to unprecedented changes with concerns about subsequent negative impacts on reefs. Surface ocean pH has dropped 0.1 units in the past century; in spite of this rapid shift in oceanic chemistry, it is unclear if individual species or life stages of Caribbean stony corals will be more sensitive to ocean acidification (OA). Examined is the relationship between CO₂-induced seawater acidification, net calcification, photosynthesis, and respiration in three model Caribbean …

Intrinsic Challenges In Ancient Microbiome Reconstruction Using 16s Rrna Gene Amplification, Kirsten Ziesemer, Allison Mann, Krithivasan Sankaranarayanan, Hannes Schroeder, Andrew T. Ozga, Bernd W. Brandt, Egija Zaura, Andrea Waters-Rist, Menno Hoogland, Domingo C. Salazar-Garcia, Mark Aldenderfer, Camilla Speller, Jessica Hendy, Darlene A. Weston, Sandy J. Macdonald, Gavin H. Thomas, Matthew J. Collins, Cecil M. Lewis Jr., Corinne Hofman, Christina Warinner

Biology Faculty Articles

To date, characterization of ancient oral (dental calculus) and gut (coprolite) microbiota has been primarily accomplished through a metataxonomic approach involving targeted amplification of one or more variable regions in the 16S rRNA gene. Specifically, the V3 region (E. coli341–534) of this gene has been suggested as an excellent candidate for ancient DNA amplification and microbial community reconstruction. However, in practice this metataxonomic approach often produces highly skewed taxonomic frequency data. In this study, we use non-targeted (shotgun metagenomics) sequencing methods to better understand skewed microbial profiles observed in four ancient dental calculus specimens previously analyzed by amplicon …

The Genome Russia Project: Closing The Largest Remaining Omission On The World Genome Map, T. K. Oleksyk, Vladimir Brukhin, Stephen J. O'Brien

Biology Faculty Articles

We are witnessing the great era of genome exploration of the world, as genetic variation in people is being detailed across multiple varied world populations in an effort unprecedented since the first human genome sequence appeared in 2001. However, these efforts have yet to produce a comprehensive mapping of humankind, because important regions of modern human civilization remain unexplored. The Genome Russia Project promises to fill one of the largest gaps, the expansive regions across the Russian Federation, informing not just medical genomics of the territories, but also the migration settlements of historic and pre-historic Eurasian peoples.

Bacterial Community Dynamics In Marine Sponge Cinachyrella Kuekenthali Under Irradiance And Antibiotics, Nidhi Vijayan

HCNSO Student Theses and Dissertations

The Marine sponge Cinachyrella sp used in this study are commonly found in offshore South Florida and Caribbean waters and appeared to be resilient in closed system aquaculture. Marine sponges host diverse bacterial symbionts that are distinct compared to bacteria found in ambient seawater, however the roles of a large fraction of the bacterial community in marine sponges are unknown. Comparison of symbiotic to aposymbiotic (bacteria-free) sponges could provide information about interactions (metabolic and physiologic) between the bacteria and sponge. In this study, a single Cinachyrella kuekenthali individual was subsectioned into explants (N=240) in order to provide identical bacterial communities …

The Current Volume 26 : Issue 12, Nova Southeastern University

Student Newspapers

No abstract provided.

Color Of Porcelain Veneer After Final Cementation In Comparison To Try-In Paste And Permanent Cement: An In Vitro Study, Abdulelah Aldahlawi

Student Theses, Dissertations and Capstones

Objectives: To evaluate and compare the color of porcelain veneers with try-in paste in relation to porcelain veneers with permanent cement. Also, to evaluate and compare combinations of three different shades and thicknesses of porcelain veneers and three cement shades before and after final cementation. Additionally, to evaluate and compare the color of porcelain veneers with cured permanent cement before and after aging. Background: Porcelain veneers and ceramic restorations have become one of the most popular approaches in the anterior area due to their natural appearance and esthetics. However, more conservative approaches have led to thinner restorations with increased translucency. …

Sampling In Qualitative Research: Insights From An Overview Of The Methods Literature, Stephen J. Gentles, Cathy Charles, Jenny Ploeg, K. Ann Mckibbon

The Qualitative Report

The methods literature regarding sampling in qualitative research is characterized by important inconsistencies and ambiguities, which can be problematic for students and researchers seeking a clear and coherent understanding. In this article we present insights about sampling in qualitative research derived from a systematic methods overview we conducted of the literature from three research traditions: grounded theory, phenomenology, and case study. We identified and selected influential methods literature from each tradition using a purposeful and transparent procedure, abstracted textual data using structured abstraction forms, and used a multistep approach for deriving conclusions from the data. We organize the findings from …

The Current Volume 26 : Issue 11, Nova Southeastern University

Student Newspapers

No abstract provided.

Fall 2015 - Hips Newsletter, Department Of History And Political Science

Department of History and Political Science Newsletter

No abstract provided.