Digital Commons Network^™

Il-34 Exacerbates Pathogenic Features Of Alzheimer's Disease And Calvaria Osteolysis In Triple Transgenic (3x-Tg) Female Mice., Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A. Kacena, Alexandru Movila

HPD Articles

Hallmark features of Alzheimer's disease (AD) include elevated accumulation of aggregated Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation. Emerging evidence indicated that interleukin-34 (IL-34) contributes to AD and inflammatory osteolysis via the colony-stimulating factor-1 receptor (CSF-1r). In addition, CSF-1r is also activated by macrophage colony-stimulating factor-1 (M-CSF). While the role of M-CSF in bone physiology and pathology is well addressed, it remains controversial whether IL-34-mediated signaling promotes osteolysis, neurodegeneration, and neuroinflammation in relation to AD. In this study, we injected 3x-Tg mice with mouse recombinant IL-34 protein over the calvaria bone every other day for 42 days. Then, …

Race Differences In Pain And Pain-Related Risk Factors Among Former Professional American-Style Football Players., Robert R. Edwards, Can Ozan Tan, Inana Dairi, Alicia J. Whittington, Julius Dewayne Thomas, Claudia M. Campbell, Edgar Ross, Herman A. Taylor, Marc Weisskopf, Aaron L. Baggish, Ross Zafonte, Rachel Grashow

Faculty Articles

The burden of pain is unequal across demographic groups, with broad and persisting race differences in pain-related outcomes in the United States. Members of racial and ethnic minorities frequently report more pervasive and severe pain compared with those in the majority, with at least some disparity attributable to differences in socioeconomic status. Whether race disparities in pain-related health outcomes exist among former professional football players is unknown. We examined the association of race with pain outcomes among 3995 former professional American-style football players who self-identified as either Black or White. Black players reported more intense pain and higher levels of …

Nsu Kpcom Link - Fall 2023 - Volume 2.3, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Sharksrx Newsletter Fall 2023, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Introduction For Tqr Special Issue: “International Scholarship For Qualitative Theory, Methods, And Analysis”, Elizabeth M. Pope, António Pedro Costa

The Qualitative Report

The field of qualitative research is robust and nuanced. While there are foundational standards to which all researchers hold, many intricacies regarding theory, methods, and analysis are influenced by differing training and expectations. These latter components are themselves often influenced by the norms of culture and geographic location. Researchers can learn much from international inquiry. In this introduction to the special issue of The Qualitative Report, “International Scholarship for Qualitative Theory, Methods, and Analysis,” we briefly consider the benefits and challenges that come from international scholarship. We then introduce the articles in the issue and their connection with the …

Editorial: Are Mitochondrial Therapeutics The Next Disruptor In Molecular Healthcare?, Benedict Albensi

HPD Articles

No abstract provided.

Opioid Impacts On Cardiovascular Health, Erjola Toska, Harvey N. Mayrovitz

HPD Articles

The prevalence of opioid use in the current opioid epidemic era has led to a public health emergency due to the ties to mortality and morbidity. Studies have investigated opioids’ impacts on different aspects of cardiovascular health, although there seems to be a lack of a current concise review. Therefore, the aim of this literature review is to provide a summary of the most recent studies from the past decade that postulate a connection between opioids and their impact on cardiovascular health while highlighting conflicting areas among published research. For this literature review, three databases, PubMed (NLM), EMBASE, and Web …

Long-Term Evaluation Of Clinical Success And Safety Of Omadacycline In Nontuberculous Mycobacteria Infections: A Retrospective, Multicenter Cohort Of Real-World Health Outcomes., Amer El Ghali, Taylor Morrisette, Sara Alosaimy, Kristen Lucas, Maria G Tupayachi-Ortiz, Raaga Vemula, Carly Wadle, Julie V Philley, Carlos Mejia-Chew, Yasir Hamad, Ryan W Stevens, John D Zeuli, Andrew J Webb, Christina T Fiske, Anahit Simonyan, Christo L Cimino, Mehriban Mammadova, Virginia E Umana, Rodrigo Hasbun, Saira Butt, Kyle C Molina, Michael Thomas, Emily A Kaip, Jeannette Bouchard, Tristan W Gore, Catessa Howard, M Gabriela Cabanilla, Dana J Holger, Jeremy J Frens, Melissa Barger, Aaron Ong, Keira A Cohen, Michael J Rybak

HPD Articles

Infections due to nontuberculous mycobacteria (NTM) continue to increase in prevalence, leading to problematic clinical outcomes. Omadacycline (OMC) is an aminomethylcycline antibiotic with FDA orphan drug and fast-track designations for pulmonary NTM infections, including Mycobacteroides abscessus (MAB). This multicenter retrospective study across 16 U.S. medical institutions from January 2020 to March 2023 examined the long-term clinical success, safety, and tolerability of OMC for NTM infections. The cohort included patients aged ≥18 yr, who were clinically evaluable, and` had been treated with OMC for ≥3 mo without a previous diagnosis of cystic fibrosis. The primary outcome was 3 mo clinical success, …

An Immunohistochemical Anomaly: A Case Report And Systematic Review Of Myofibroblastoma Of The Breast, Mohamad Kaki, Sarah Klein, Chinar Singh, Breanne Kothe, Jose Martin

HPD Articles

Myofibroblastoma (MFB) is a rare but benign mesenchymal tumor most commonly appearing within breast tissue. Most cases of MFB occur in postmenopausal women and are treated by surgical excision. The diagnosis of MFB is made through immunohistochemical (IHC) analysis, with the most common biomarkers being CD34+, desmin+, smooth muscle actin+, and vimentin+. In this article, we describe a case of an MFB in a premenopausal female with variance from classic IHC findings. We also performed a systemic review of the MFB of the breast. The systemic review compiles the most common IHC findings of MFB, patient demographics, treatment methods, lesion …

Anchoring On Hyperglycemia And Sepsis In The Presence Of An Unforeseen Thyroid Storm, Andrew M. Joseph, Monica Karas, Victor H. Camba, Brian M. Martin, John Preece

HPD Articles

Thyroid storm (TS) is a relatively rare but life-threatening complication of an overactive thyroid that can manifest in a myriad of ways due to its multisystem involvement. Due to its relatively high mortality rate, it is essential that TS is recognized and treated promptly. TS can occur due to trauma, drugs, and sepsis. Identifying TS as a diagnosis is challenging to pinpoint due to its similar presentation to more common pathologies like sepsis and diabetic ketoacidosis (DKA). Here, we present a case of a 31-year-old African-American woman with type 2 diabetes mellitus following sepsis secondary to Escherichia coli pyelonephritis and …

Impacts Of Skin Color And Hypoxemia On Noninvasive Assessment Of Peripheral Blood Oxygen Saturation: A Scoping Review, Kawaiola C. Aoki, Maya Barrant, Mam Jarra Gai, Marina M. Handal, Vivian Xu, Harvey N. Mayrovitz

HPD Articles

Standard pulse oximeters estimate arterial blood saturation (SaO2 ) non-invasively by emitting and detecting light of a specific wavelength through a cutaneous vascular bed, such as a digit or the ear lobe. The quantity measured at these peripheral sites is designated as oxygen saturation (SpO2 ). Most reliable pulse oximeters are calibrated from measurements of healthy volunteers using some form of oxygen desaturation method. As the degree of inducible hypoxemia is limited, the calibration below achievable desaturation levels is usually extrapolated, leading to potential measurement error at low SaO2 values, especially in highly pigmented skin. Such skin color-related errors (SCRE) …

Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber

HPD Articles

OBJECTIVES: The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient-reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant-retained/supported dental prostheses were addressed.

MATERIALS AND METHODS: Three systematic reviews formed the basis for discussion. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary of the 7th ITI Consensus Conference, taking …

Weight Loss And Competition Weight Comparing Male And Female Mixed Martial Artists Competing In The Ultimate Fighting Championship’S (Ufc) Flyweight Division, Corey Peacock, Justin Braun, Gabriel J. Sanders, Anthony A. Ricci, Charles Stull, Duncan French, Cassandra Evans, Jose Antonio

HPD Articles

Background: Although there is much literature demonstrating weight changes in professional mixed martial arts (MMA) athletes, there is minimal data comparing male and female MMA athletes. Therefore, the purpose of the current study was to compare weight changes between professional male and female MMA athletes leading up to competition. Methods: One hundred and three professional flyweight MMA athletes competing for the Ultimate Fighting Championship (UFC) were used for the study. Weight was obtained at multiple time points leading up to the competition. Two-way ANOVAs and post hoc t-tests were used, and significance was set at p ≤ 0.05. Results: ANOVA …

Understanding Expatriates' Cultural Adjustment And Performance In International Assignments, Iskra Reic

The Qualitative Report

The aim of this research is to explore the experience of expatriates about cultural differences between home and host countries through a narrative inquiry. There is not enough information in the literature about expatriates’ experiences and how they see the role of cultural differences, cultural distance and cultural competences in adapting to international assignments. Therefore, main research question was how expatriates working in a large multinational pharmaceutical company perceive the role of cultural differences and cultural competencies in their adjustment and performance. A total of 12 expatriates from different home countries on assignment in different host countries participated in the …

Social Determinants Of Health Impacting Access To Renal Dialysis For Racial/Ethnic Minorities, Joseph L. Mercen, Kiely Curran, Markeeta T. Belmar, Jaron Sanchez, Ibrahim Hasan, Sahib Kalra, Parth M. Raina, Sahil Patel, Dania Arrechavaleta, Vincent Lee, Paula Anderson

HPD Articles

Although widespread, the burden of disease presented by chronic kidney disease (CKD) is not equally distributed among all demographics. Examining the social determinants of health (SDOH) that relate to barriers to renal dialysis care in CKD can help to prevent future disparities. There has not been a study addressing the social factors that create barriers to care for ethnic minority patients with CKD. The aim of this scoping review is to address the SDOH that affects access to renal dialysis for ethnic minority patients in the United States. This study was based on the protocol published by the Joanna Briggs …

Atherosclerosis Preventive Effects Of Marrubiin Against (Tnf-Α)-Induced Oxidative Stress And Apoptosis, Ailar Nakhlband, Alireza Garjani, Nazli Saeedi, Yadollah Omidi, Samad Ghaffari, Jaleh Barar, Morteza Eskandani

HPD Articles

Introduction: Atherosclerosis is a complicated cascade of inflammatory processes, oxidative stress, and apoptosis, making it the most prevalent cardiovascular disease. The onset and progression of cardiovascular diseases are greatly influenced by oxidative stress. Targeting oxidative stress is an effective strategy for treating such diseases. Marrubiin is a bioactive furan labdane diterpenoid acts as a strong antioxidant to protect against oxidative damage. This study aimed to investigate the protective effects of marrubiin against oxidative stress and apoptosis in a cellular model of the vascular system. Methods: Human umbilical vein endothelial cells were treated with varying concentration of marrubiin and its IC50 …

Flexibility & Iteration: Exploring The Potential Of Large Language Models In Developing And Refining Interview Protocols, Jessica L. Parker, Veronica M. Richard, Kimberly Becker

The Qualitative Report

This article investigates the potential of Large Language Model (LLM) tools like ChatGPT in aiding researchers in the development and refinement of interview protocols. We found that ChatGPT could generate appropriate interview questions, craft key questions, provide feedback on protocols, and simulate interviews, indicating its potential to reduce time and effort, particularly when human resources are limited. This article builds upon previous authors’ insights and suggestions regarding developing and refining interview protocols to maximize the chances of achieving research aims, especially for novice researchers. Additionally, the researchers highlight the flexibility of these tools in adapting to different research contexts and …

Facilitating Communities Of Practice: A Case Study, Jukka Ojasalo, Marius Wait, Ronan Maclaverty

The Qualitative Report

Communities of practice (CoP) have become a popular source of knowledge-sharing and learning in organizations. However, several problems occur in managing them and more knowledge about this area is needed. This article addresses this knowledge gap and aims to understand and describe how to facilitate communities of practice in a large corporation. The research draws on a qualitative case study based on interviews with people involved in CoPs in a large multinational technology company and the analysis followed the method introduced by Gioia et al. (2013). The findings relate to participants' conceptions of the nature of CoPs, how CoPs align …

Effect Of Action Observation Therapy On Pain, Kinesiophobia, Function, And Quality Of Life In Adhesive Capsulitis Patients, Prachita Walankar, Dhruvi Shah

Internet Journal of Allied Health Sciences and Practice

Background: Adhesive capsulitis is a common musculoskeletal health problem. Cortical changes along with maladaptive pain behavior has been reported in literature. There is a need to implement biopsychosocial rehabilitation approaches to achieve successful outcomes. Hence, this study aims to evaluate the effect of action observation therapy (AOT) on pain, kinesiophobia, function and quality of life in adhesive capsulitis patients. Methods: This single-center, prospective study was conducted in a group of 30 persons diagnosed with adhesive capsulitis patients (19 males, 11 females). Patients were randomly assigned into two groups. Patients in one group were given AOT along with conventional exercises, while …

Student Perceptions Of Reading Preparation And Textbook Use In Professional Allied Health Programs, Laura Stimler, Camille Skubik-Peplaski, Melba G. Custer, Shirley P. O'Brien

Internet Journal of Allied Health Sciences and Practice

Purpose: In professional allied health education, textbooks are central to developing course content, student learning and certification exams, but little is known about the graduate student’s perspective. This study was intended to describe current trends in graduate students’ point of view, habits and opinions related to buying and using textbooks and other resources in allied health education. Methods: This was a multi-site collaborative research project. An electronic survey was developed to gather data on student habits and perspectives regarding textbook preferences including digital texts, academic reading, exam preparation, and obtaining course materials. The survey was distributed across four academic institutions. …

Intraprofessional Education In Allied Health And Nursing Curricula, Kayla Galvan, Dianna Lunsford

Internet Journal of Allied Health Sciences and Practice

Abstract

Purpose: Throughout all healthcare systems, healthcare workers collaborate interprofessionally and intraprofessionally. Studies show that successful teamwork within a healthcare team leads to an increase in patient satisfaction and outcomes. The purpose of this scoping review is to explore and examine the literature on allied health and nursing intraprofessional education and determine best approaches for educators to successfully implement intraprofessional education in allied health and nursing curriculums. Method: A literature search was conducted between July 7, 2022 through July 9, 2022. The Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews (PRISMA- ScR) was used for this …

Preparing Students For The National Physical Therapist Examination (Npte): One Program’S Experience With Using The Practice Exam And Assessment Tool (Peat) As A Graduation Requirement, Sandra Campbell, Kripa Dholakia, Lynne Sturgill, Robert Wellmon

Internet Journal of Allied Health Sciences and Practice

Purpose. Factors related to National Physical Therapist Examination (NPTE) performance have been widely reported in the literature, yet no strong predictors emerge offering faculty guidance on how to determine student readiness for the NPTE .The Practice Exam and Assessment Tool (PEAT) as a graduation requirement may give insight into readiness for the NPTE. Widener University transitioned from a faculty generated comprehensive examination (FGCE) to the PEAT using Lewin’s Planned Change Model. The purposes of this study were to (1) describe one program’s transition away from a FGCE to the PEAT, (2) present findings of a data driven process to assess …

The Use Of Dynamic 3d Printed Cervical Spine Models In A Musculoskeletal Physical Therapy Course, Cassandra I. Ciorciari, Dallas A. Rynda, Christina L. Fojas

Internet Journal of Allied Health Sciences and Practice

Purpose: While mass-produced anatomical models are commercially available, many models are inflexible and static, and may not meet the needs of health professions students. Advances in three-dimensional (3D) printing have demonstrated tremendous potential for enhancing student learning. This study uses 3D printed cervical spine models to explore whether use of dynamic, flexible models improve student learning in a cohort of physical therapy students. Methods: 3D printed models of the cervical spine and occiput were printed using a fused deposition modeling 3D printer and polylactic acid filament, and augmented with hook and loop fasteners, foam sheets, and cords to simulate structures …

The Impact Of Experiential Learning In A Pro Bono Ot Clinic On Clinical Reasoning Development, Julie Sandvig, Debra Hanson, Paula Kitzenberg

Internet Journal of Allied Health Sciences and Practice

Abstract

Fieldwork educators have expressed concerns about the readiness of occupational therapy students for clinical reasoning in the practice setting. Experiential learning involving face-to-face personal interactions with clients facilitates the application of theoretical knowledge, and the development of professional skills, competence, and self-confidence. Having the opportunity for extensive hands-on time working with clients, such as is offered in a pro bono clinic structure, may positively impact student clinical reasoning development of occupational therapy students.

Purpose: The purpose of this study was to explore the impact of participation in a student-run occupational therapy pro bono clinic on student perceptions of clinical …

The Effectiveness Of Serotonin And Tricyclic Antidepressants In Tinnitus Management: A Rapid Review, Dr. Emilie Vos, Dr. Nannette Nicholson, Melinda Johnson, Dr. Karah Gottschalk

Internet Journal of Allied Health Sciences and Practice

Background: Tinnitus can be defined as a health condition characterized by the perception of sound, either in the head and/or ears, in the absence of any external acoustic stimulus. Perception is often quantified by self-report, or the use of patient reported outcome measures (PROMs). The purpose of this rapid review was to evaluate the level and quality of evidence regarding the use of serotonin and norepinephrine reuptake inhibitors (SNRI), selective serotonin reuptake inhibitors (SSRI), and tricyclic antidepressants as measured by tinnitus patient-reported outcome measures (PROMs) and/or Visual Analog Scales (VAS). Methods: The Cochrane Rapid Review guidelines were followed. The PICO …

Effect Of Posterior Leaf Spring And Carbon Composite Ankle Foot Orthosis On Gait And Functional Mobility Of Stroke Survivors With Hemiplegia: A Randomized Clinical Trial, Zidikheri B. Msechu, Ahmad Zaheer Qureshi, Tim Drew

Internet Journal of Allied Health Sciences and Practice

Purpose: The study was carried out as a randomized clinical trial to assess the effect of posterior leaf spring ankle foot orthosis (PLS-AFO) and carbon composite ankle foot orthosis (C-AFO) on functional mobility, walking speed and satisfaction among stroke survivors with hemiplegia. Methods: Twenty-seven ambulatory stroke survivors with hemiplegia who had completed a rehabilitation program and were already using an ankle foot orthosis (AFO) were included in the study. Subjects were randomly assigned either PLS-AFO or C-AFO and assessment was done with and without their AFOs. Functional mobility, walking speed, and satisfaction were assessed using the Timed Up and …

Allied Health Professions In Research: The Forgotten Workforce, Sarah Baker, Lisa Ballantine

Internet Journal of Allied Health Sciences and Practice

Purpose: To understand the experience, involvement, and perceived importance of research among allied health professions and identify how robust research culture might be established in secondary care. Method: Analyses were carried out on quantitative and qualitative data using an online questionnaire disseminated to allied health professionals working in a national health service trust in the north of England. Logistic regression was used to ascertain whether Agenda for Change banding and profession significantly influenced research qualifications, experience, and interest. Qualitative data was analysed within a theoretical framework that focused on, career development, job satisfaction and clinical practice. Results: Educational attainment, research …

Occurrence Of Temporomandibular Disorder In Subjects With Low Back Pain And Spinal Postural Deformities: An Observational Study, Vijay Kage, Aarti Welling, Richa Desai

Internet Journal of Allied Health Sciences and Practice

Purpose: Back pain and temporomandibular disorder (TMD) are two predominant illnesses that affect the human motor system. Literature has stated significant associations between chronic low back pain (CLBP) and TMD. Global postural deviations cause body adaptation and realignment, which may interfere with the function of TMJ. However, the possibility of TMD in subjects with CLBP associated with spinal postural deformities has yet to be completely explored. Method: This was an observational study carried out among 65 people having CLBP with co-presence of any spinal deformities. Forward head posture (FHP) was assessed using the On-Protractor application and thoracic kyphosis and lumbar …

Gross Motor Assessment Tools For Children 0-12 Years Of Age Using Telehealth: A Scoping Review, Claire M. Grant, Anne Jones, Michael Crowe, Helen Land

Internet Journal of Allied Health Sciences and Practice

Objective: The objective of this review was to understand the scope of evidence relating to the use of telehealth for gross motor assessment tools in children 0-12 years of age.

Background: Telehealth has been widely used by physiotherapists since the start of the Covid-19 pandemic, however little is known about the validity and reliability of using gross motor assessment tools via telehealth. Gross motor assessment tools are used by physiotherapists to understand motor function, support diagnoses of motor disorders, plan and evaluate interventions. Qualitative research identifies a lack of confidence by physiotherapists in undertaking physical assessment via telehealth.

Method: A …

Influence Of Apathy And Grit On Exercise Adherence For Persons With Parkinson’S Disease: A Cohort Study, Erica J. Kiernan, Evan M. Pucillo, Christopher M. Wiedman

Internet Journal of Allied Health Sciences and Practice

Purpose: Parkinson’s disease (PD) is the second most common neurodegenerative disease in the United States. A preponderance of evidence supports exercise and physical activity as an effective intervention to slow the progression of motor symptoms in persons with PD. However, less study has been given to the influence of non-motor symptoms of PD, such as apathy and grit, on adherence to therapeutic exercise programs. The primary aim of this study was to characterize levels of apathy and grit in individuals with PD and explore any relationship to adherence in a community exercise program. Due to the importance of caregiver interaction, …