Digital Commons Network^™

Red Dog Loess, A Last Glacial Dust Deposit, White River Badlands, S.D., Lakshmi Srikari Ravulaparthi, Ian Chang, Haley Perkins, John Nichols, Curtis Frye

Undergraduate Student Symposium

Understanding the detrimental effects of prehistoric climate change is essential to understanding our potential for future global climate disasters. During the Last Glacial Period (LGP) beginning around 70 thousand years ago, as Earth’s temperature dropped, the midcontinent grew increasingly dry, resulting in the ecological collapse of the Great Plains grassland ecosystems. Due to the breakdown of the grasslands, wind eroded the Great Plains, depositing vast amounts of windblown dust (loess). These loess deposits form valuable midcontinental agricultural deposits in Nebraska and Iowa. This study aims to identify the origin of the loess found on mesas in the White River Badlands …

Reducing Inoculum Effect By Modulating Growth Productivity Through The Superpathway Of Purine, Pyrimidine And Histidine Synthesis In Escherichia Coli, Melissa Marzouk, Daniella Hernandez, Allison J. Lopatkin Ph.D.

Undergraduate Student Symposium

It is estimated that by 2050, 10 million people will die annually due to infections caused by antibiotic resistant bacteria. An understanding of the mechanisms that bacteria use to resist antibiotics is essential for extending the usefulness of our existing antibiotics. One mechanism that bacteria use to resist antibiotics is the inoculum effect (IE). During IE, high-density bacterial populations require higher concentrations of antibiotics to be killed compared to low-density bacterial populations. Recently, it has been discovered that growth productivity, defined as the relationship between ATP and growth rate, can explain IE for multiple antibiotics. If growth productivity is sufficiently …

Regulatory Roles For Stress Responsive Transposable Elements In Rice, Jenna Handal, Michael Egozi, Andy Pereira Ph.D.

Undergraduate Student Symposium

Transposable elements, or mobile DNA sequences, are known for their structural and functional roles in the rice genome. As sources of genetic variation and drivers of evolution, transposable elements have been extensively studied for their regulation of gene expression and alteration of phenotypic traits. In addition, transposable elements are shown to be activated in response to various biotic and abiotic stresses. As the global temperature rises, heat stress threatens crop production worldwide. Research has shown that heat stress hinders optimal rice growth, development, and yield. Concern for food security amidst a growing population calls for development of novel methods to …

Research In Anatomy And Physiology During Covid-19: Global Lessons Learnt And Future Recommendations, Jeet Patel, Harsh Chheda

Undergraduate Student Symposium

The persistent Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused significant disruptions of research studies within the fields of Anatomy and Physiology. As the pandemic resulted in many governmental and institutional restrictions, it became increasingly challenging to pursue research in general. Disciplines like Anatomy and Physiology that require kinesthetic/tactile application of concepts or testing hypotheses through hands-on active engagement were either halted or slowed down, as the new social guidelines and risks to certain groups of people hindered up-to-date researchdata collection. This called for the design and adoption of innovative scientific and technological research tools and protocols. An effort to help …

Sargassum Accumulation At Von D. Mizell-Eula Johnson State Park, Giavanna Iglio, Jarod Johnson, Kayla Jones, Kaleb Myers, Juliana Ottens-Rivera, Aidan Pflieger, Manuel Ploner, Kevin Rafferty, Maura Wondra

Undergraduate Student Symposium

Sargassum is a typically floating phaeophyte (brown alga) with important ecosystem functions. It is a producer, generating biomass via photosynthesis, and providing habitat for small epipelagic organisms in the open ocean. In August 2022, large amounts of Sargassum were seen on the beach at the northern end of Von D. Mizell-Eula Johnson State Park (VDMEJSP), Dania Beach, Florida, up to 152cm thick. This disturbs the intertidal environment, which is typically composed of carbonate sands, and smothers infauna. Furthermore, this creates ephemeral habitats for species not typically associated here. The extent of Sargassum deposits was measured from 7 September through 25 …

Semantic Priming Across Many Languages, Ramsha Ahmed, Aishwarya Muppoor, Michelle Gruboy, Ishani Patel, Riya Patel, Sneh Patel

Undergraduate Student Symposium

The Psychological Science Accelerator (PSA) is a globally distributed network of labs that conducts studies with the goals of inclusion and transparency. Crowdsourcing data worldwide enables research to be generalized through diverse participants with unique language backgrounds providing worldwide multilingual data. The PSA makes opportunities available for researchers to network and replicate studies. We have been collecting data on a study organized by the PSA. In addition to data collection, we helped to verify translations of the consent form and protocol information from English to different languages. The study examines semantic priming, which occurs when a semantically related prime (e.g. …

Sleep Health Matters For All: Wellness Intervention For The Pediatric Down Syndrome Population, Mahima Dave

Undergraduate Student Symposium

Down syndrome (DS) is the most prevalent chromosomal disorder in which an extra copy of chromosome-21 disrupts the development of intellectual abilities. Unique physical manifestations places children with DS at high risk for obstructive sleep apnea (OSA) in which repeated blockages of the upper airway cause difficulty breathing during sleep. 80% of children with DS are afflicted with OSA, and this increases incidences of nocturnal sudden cardiac arrest by 2.57-fold compared to the general population. Manifestations of OSA, such as cognitive impairment and cardiovascular disease, are common in the DS population. However, this often obscures the diagnosis. During May 2021, …

S-Prg Eluate Downregulates Osteoclastogenesis: S-Prg's Possible Indication For Subgingival Caries, Janaki Chandra

Undergraduate Student Symposium

Surface pre-reacted glass-ionomer (S-PRG) is a new bioactive filler that has been used for the restoration of tooth decay. S-PRG’s unique property to release six types of bioactive ions, including fluoride (F−), prevents the adhesion of dental plaque to tooth surface while suppressing tooth demineralization. Although S-PRG may be potentially used for subgingival caries restoration, the possible effect of S-PRG on the pathogenically promoted bone absorption in periodontitis remains unclear. The aim of this study is to investigate the possible inhibitory effect of S-PRG eluate on osteoclasto-genesis (OC-genesis) in vitro. S-PRG elute at the sublethal concentrations, which were formerly …

Synthesis Of Metal Binding Polymers Via Raft Polymerization Of Activated Ester Monomers And Post-Polymerization Functionalization, Francisco Castro Wetzstein, Meha Pandya

Undergraduate Student Symposium

Poly pentafluorophenyl acrylate (PPFPA) is an activated ester polymer used for the binding and removal of toxic metals out of solution through filtration. PPFPA was synthesized via reversible additionfragmentation chain transfer (RAFT) polymerization using pentafluorophenyl acrylate (PFPA) as the monomer to create linear and hyperbranched polymers. RAFT polymerization allows control over molecular weight and the molecular architecture of PPFPA. H-NMR and F-NMR spectroscopy was utilized to assess monomer purity, polymer conversion, and confirm the structure of the final polymer. The purpose of this study is to synthesize PPFPA, a chelating polymer, as well as to functionalize said polymer with different …

Synthesis Of Polymer-Drug Conjugates For Controlled Transdermal Drug Delivery, Ashley Guillen-Tapia, Esha Sultana

Undergraduate Student Symposium

Polymer drug conjugates represent a novel approach for drug delivery belonging to polymer therapeutics. These nano-drug delivery systems consist of biocompatible monomers covalently linked to drug molecules. One of the most recently developed methods of drug delivery is transdermal drug delivery systems (TDDS). A non-invasive alternative to needle injections, TDDS offers many advantages as it exhibits high drug loading and controlled drug release. While transdermal drug delivery systems based on polymeric micelles have been previously studied, there is limited knowledge of how polymer block length and micelle size affect the drug loading and drug release profile. This project aims to …

The Abundance Of Streptococcus Mutans Within The Oral Cavity Of University Students And Implications For Disease Etiology, Esha Manku

Undergraduate Student Symposium

Microorganisms within the human oral cavity are part of a healthy ecosystem but can also contribute to disease states by increasing the severity of dental caries, the incidence of gingivitis, and the onset of periodontitis. In particular, patients with poor oral health exhibit a significant increase the pathogenic microbe Streptococcus mutans. However, research shows that S. mutans abundance may be related to a SNP within the human genome (an A/G substitution at rs7294985 in the microsomal glutathione-Stransferase 1 (MGST1) gene). Here we address the role of S. mutans abundance and SNP genotype ratios within a healthy student population (n …

The Effect Of Anti-Angiogenic Agents Jfd And F16 On The Cell Cycle Arrest And Apoptosis Mechanisms In U87 And T98 Glioblastoma Cells, Sri Vaishnavi Konagalla, Ritu Upadhyay

Undergraduate Student Symposium

Glioblastoma multiforme (GBM) is an aggressive type of cancer that can occur in the brain or spinal cord, with a 5-year survival rate of only 5%. Two novel anti-angiogenic agents, JFD and F16, have been developed and seem to be favorable for treating GBM. They work by inhibiting tumor angiogenesis, which is the formation of new blood vessels that plays a pivotal role in tumor growth. JFD is a small molecule that was developed for blocking vascular endothelial growth factor receptor (VEGFR). F16 is the second small molecule that can cross the blood brain barrier and block angiogenesis in tumors …

The Effect Of Sexual Behavior, Gender Identity, And Sexual Orientation On Mental Health Among Adolescents: A Scoping Review, Anthony Arango

Undergraduate Student Symposium

Recent CDC data from 2021 indicates an excess of one-third of high school students are struggling with poor mental health, which is a major public health concern. There is a growing body of literature about the relationship between sexual orientation and gender identity on mental health among adolescents, highlighting the need for further research on the intersection between mental health and sexuality in this vulnerable population. The objective of this scoping review is to provide a comprehensive understanding of existing literature on the relationship between sexual behaviors, gender identity, and sexual orientation on mental health among adolescents. A scoping review …

The Effects Of Forced Exercise On Traumatic Brain Injury, Courtney Mai, Drew Smith, Juanita Castillo, Karla Munoz

Undergraduate Student Symposium

Traumatic brain injury (TBI) is a worldwide public health problem that can alter daily function and quality of life. TBIs affects approximately 1.5 million people in the United States annually and 300,000 of these TBIs are sports-related. Sports-related TBIs are generally known as concussions and have garnered attention due to the neurobehavioral outcomes that could arise from athletic training or exercise. This study aims to examine how forced exercise can affect TBI. This study was conducted by inducing stress via forced exercise and mild TBIs. Behavioral tests included elevated zero maze, novel object recognition, open field, and sucrose preference. Currently, …

The Role Of Inflammatory Cytokines In Alzheimer's Disease, Moha Jayram

Undergraduate Student Symposium

Alzheimer’s disease (AD), the most frequent cause of dementia and disability in the elderly, results in non-reversible neurodegenerative alterations of the brain such as synaptic and neuronal loss, extracellular amyloid deposits, and intra-cellular deposition of degenerate filaments. It has been hypothesized that inflammatory cytokines have been linked to Alzheimer disease (AD) neurodegeneration and disease progression. To test this hypothesis a systematic review and data meta-analysis was conducted from thirty prevalent studies. Identified representative studies from various counties were found using national studies using the search query Alzheimer’s Disease:Inflammation:Cytokines:Dementia:Progression. All of the studies included data from the elderly adult population with …

Tree Canopy Biodiversity In An Urban Forestry Setting On Nova Southeastern University's Main Campus, Corinne Renshaw, Mackenzie Soligon, Guenevere Coury, James Puentes

Undergraduate Student Symposium

Urban forests are important for the mitigation of flooding and dissipation of heat-island effects, resulting in the offset of energy costs for urban areas. An analysis of tree canopy biodiversity at Nova Southeastern University’s (NSU’s) main campus was done to create a baseline of tree biodiversity and study how landscape management can become more sustainable. In 2022, 10 of the 36 zones, from a 2017 hurricane damage assessment map of NSU, were surveyed. In 2023, an additional 10 zones were surveyed, totaling 1,458 trees. The precise location of each tree was plotted on TreePlotter and the diversity data was analyzed …

Understanding The Link Between Parity And Dementia, Chana Vogel, Aditi Gorthy, Isabelly Dos Santos

Undergraduate Student Symposium

Dementias, including Alzheimer’s and vascular dementia, are devastating diseases and as the aging population increases, their incidence does as well. Given the striking sex/gender difference in the prevalence of dementia, it is urgently important to understand the unique social and biological factors that predispose females. There is growing concern over potential impacts of ovarian hormones (e.g., oral contraceptive use and hormone replacement therapy during/after menopause), but reproductive experience is wildly understudied as a risk factor for dementia. Dementia is characterized by cognitive difficulties likely caused by impaired hippocampal plasticity and function. Intriguingly, postpartum females typically experience reduced hippocampal plasticity, volume, …

Usahay, Samantha Carl Selorio

Undergraduate Student Symposium

“Usahay” is a documentary short film about the relationship between a grandma with Alzheimer’s and her granddaughter. It explores the bond between the two and the difficulties they face due to the progressive disease. The Filipino word usahay means sometimes and it is reflective of the day-to-day of caregiving: Sometimes things are good, sometimes things are bad. Sometimes she remembers and sometimes she does not. It is in such moments they learn to make the most of what they have. The documentary is directed by Samantha Carl Selorio.

Using X-Ray Crystallography To Inform Small Molecule Drug Design, Ilana Kolomiyets, Shreya Surti

Undergraduate Student Symposium

This project involves organic synthesis, X-ray crystallography, and the design of small molecule drugs. The ultimate goal of this project is to better understand the forces that affect the conformation of small molecules in order to develop more effective cancer therapeutics. The key molecule in this project is in reminiscent of an indole-2-carboxamide, and past research has shown that these molecules have antitumor and apoptotic effects against a variety of cancer cells. The crystals of this molecule were orthorhombic in P2₁2₁2₁ with unit cell dimensions a = 14.0111(1), b = 17.7521(1), c = 45.0224(3) and …

When Having More Can Be Risky: Women's Resources Predict Experience As A Victim, Kortne Bajor, Tamara Bogdanova, Ariana Gonzalez, Nissipriya Pilli

Undergraduate Student Symposium

People accumulate different kinds of resources that they use to solve problems, including the problems of finding, attracting, and retaining a mate. Mate retention behaviors include all behaviors that function to maintain a long-term partner’s investment in the current relationship. Some of these behaviors are benefit-provisioning and function by enticing a person’s continued investment in the relationship by offering gifts, compliments, or other positive inducements. Previous research has demonstrated a relationship between men’s resource accumulation and men’s use of cost-inflicting versus benefitprovisioning mate retention behaviors. The objective of the current study is to further investigate the relationship between resources and …

X-Ray Crystallography Of Self-Assembling Materials, Shreya P. Surti, Ilana Kolomiyets, Zachary C. Pizzo

Undergraduate Student Symposium

This research represents an interdisciplinary collaboration between NSU and KAIST, a leading research university in South Korea, and involves organic synthesis, X-ray crystallography, and materials selfassembly. This research informs the design of a new generation of self-assembling materials with improved physical properties for biomedical and technological applications.

Through analysis of the software packages CRYSTALS and Mercury, the structure of the molecule was found. The X-ray crystal’s parameters were found to be triclinic in P1 with a = 8.7008(5), b = 11.5507(7), c = 12.8580(8), a = 69.8418(18), b = 80.9295(18), g = 88.4199(18) and a unit cell volume of 1197.41(7) …

How The Molecular Vibrations Of Water May Prevent Skin Cancer, Colette Costello, Angelina Georg, Jarlynn Ramirez, Jenna Handal, Ramson Munoz Morales

Undergraduate Student Symposium

Studies have shown that when DNA absorbs ultraviolet light it can become structurally damaged leading to a mutation and possibly skin cancer. However, exposing skin to sunlight rarely leads to a mutation. This indicates that after the ultraviolet light is absorbed by the DNA the energy from the light can either cause a structural change to the DNA (a mutation) or be dissipated in a way that does not damage the DNA. Absorption of ultraviolet light causes molecular vibrations in DNA and these vibrations are what likely leads to structural changes in the DNA. One way the structural changes could …

The Effect On Porphyrin Basicity Of Fluorine Substituted Meso Phenyl Porphyrins, Harsh Chheda, Rushi Patel, Amanda Leon, Andersen Cheong

Undergraduate Student Symposium

The protonation of meso-Tetra(2,6-difluoromethylphenyl) porphyrin (2,6-DF), meso-(3,5- difluoromethylphenyl) porphyrin (3,5-DF), and meso-Tetra(2,3,5,6-tetrafluorophenyl) porphyrin (TF) will be studied through UV vis spectroscopy. Protonation is achieved by titration of each porphyrin in toluene with trifluoroacetic acid (TFA). The depiction of a wavelength shift from the free base Soret to the protonated Soret will indicate the formation of a dication. The data from the UV spectra will be used to calculate the pKa values associated with each porphyrin. Based on the results, the average pKa for 2,6-DF upon protonation was 1.67, the average pKa for 3,5-DF was 1.75, and the average pKa for …

Effects Of Sports Outcomes On Student-Athletes' Stress Biomarkers And Scholastic Performance, Juhi Dalal, Daniela Garcia Arregui, Sara Ali, Yebin Chung, Iftikharun Nissa, Shalet James, Amber Gulau

Undergraduate Student Symposium

The winner effect occurs when the probability of continuing to win increases after winning one game; it has also been shown to involve changes in the hormones and behaviors of winners and losers. Our poster outlines a new research program that we predict will test how winner effects influence stress and academic performance in student-athletes. We present lab validation of qPCR assays of a stressassociated biomarker (mitochondrial DNA copy number; mtDNA-CN), alongside a qualitative survey we developed to give athletes before and after each game. We predict that mtDNA-CN will covary with the recent game outcome(s), and that wins will …

Associations Between Religion, Perceived Family Openness To Mental Health, And Mental Health Help-Seeking Among South Asians, Zahra Aziz, Shannon Parma, Samhita Doranala, Ariana Ali

Undergraduate Student Symposium

Comfortability in discussing mental health within families is a key determinant of help-seeking behaviors. This comfortability can be attributed to or dissociated from mental health stigma stemming from deep-rooted cultural and religious barriers. Research suggests that youth of South Asian descent, in particular, have one of the lowest rates of utilization of mental health resources. This study aims to investigate the relationship between both religious affiliation and family openness to conversations about mental health and help-seeking knowledge, attitudes, skills, and behavior among South Asians.

A cross-sectional study was conducted as part of a mental health literacy pilot project at a …

Geographically Based Risk Evaluation Of Disease States And Sleep Disorders Impacting Readiness Across Active-Duty Army Installations From Military Medical Databases In Fiscal Year 2021, Nandan Shastry

Undergraduate Student Symposium

The impact of sleep disorders and disease states on active-duty soldiers’ readiness is a clinically relevant and significant topic. This is due to the high comorbidity of sleep disorders and a wide variety of other condition, ranging from substance abuse to obesity. Patient data collected from military health databases can be used to establish possible relationships. The current study performed a risk assessment of sleep disorders, obesity, tobacco use, and general substance abuse based on geographical distribution of active-duty Army installations through a comprehensive analysis of the Office of the Army Surgeon General Health of the Force (HoF) report, specifically …

A Scoping Review Of The Role Of Per- And Polyfluoroalkyl Substances (Pfas) In Pediatric Populations, Sheril Mathew

Undergraduate Student Symposium

Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that can have a profound and negative impact on children's growth and development, leading to a higher risk of endocrine-related diseases and disorders. PFAs can be absorbed through ingestion, inhalation, or skin contact and accumulate in the body due to resistance to degradation. Furthermore, children have been found to absorb 50% more of these chemicals compared to adults, as reported by the Centers for Disease Control and Prevention (CDC). According to the National Health and Nutrition Examination Survey (NHANES) data, widespread exposure to PFAS has been documented in the US population. …

An Applied Ergonomic Analysis And Comparison Of Laparoscopic Surgical Tool Handles, Sebasthian Del-Valle, Komi Touglo-Midodji, Emmanuel Espindola, Mackensey Mcclendon

Undergraduate Student Symposium

Laparoscopic surgery is a minimally invasive surgical procedure in which surgeons operate with a camera to view the operating area and instruments inserted through minor incisions. This surgery has many benefits, including faster patient recovery, but it can also be physically demanding for surgeons. Significant muscle fatigue and cognitive effort have been observed in surgeons as they engage in prolonged use of these instruments. The handles of these instruments are not ergonomic. The purpose behind this research project is to design and test an alternative to the standard laparoscopic instrument handles. Applying human factors and ergonomics principles, we sought to …

Does Exercise Reduce Mind Wandering: The Role Of Mood And Exercise Frequency, Divya Mittal, Mahati Dharanikota, Carlos Riveria-Vasquez

Undergraduate Student Symposium

Chronic exercise provides various physical health benefits (Penedo & Dahn, 2005) but also results in a variety of benefits to cognitive functioning including improving working memory (Padilla, Perez, & Andres, 2014) and attention (de Sousa et al., 2019). Exercise also releases various endorphin hormones that contribute to increased positive mood (Rokade, 2011). However, less is known about how chronic exercise influences frequency of mind wandering. Mind wandering, defined as experiencing an off-task thought, has been linked to mood such that negative mood predicts higher rates of mind wandering (Smallwood & O’Connor, 2011). The current study examined the relationship between exercise …

Effect Of Methylphenidate On Alzheimer's And Dementia, Smrithi Mukund, Priyanka Prasanna, Aishwarya Muppoor, Maheen Khan

Undergraduate Student Symposium

Alzheimer's disease (AD), the most common form of dementia, is a neurogenerative disorder that causes impairments in cognitive abilities, behavior, and personality. AD is distinguished by extracellular plaques containing beta-amyloid proteins and intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. Current FDA-approved drugs for AD have questionable efficacy and carry potential risks. Methylphenidate (Ritalin), a stimulant drug currently used to treat ADHD and narcolepsy, has been used off-label to treat AD patients, primarily for relieving the symptom of apathy. While our literature review suggests that relatively short-term (< 6 weeks) use in patients with AD and related diseases is safe and effective in clinical trials, little is known about the longer-term effects of the drug in this population. More work is needed, as there is also a paucity of animal research investigating chronic effects of methylphenidate in rodent models of AD and related disorders. Findings from animal studies in wild-type rodents on chronic use of methylphenidate, as well as cell culture studies, have reported adverse effects of methylphenidate, including increases in neuroinflammation and oxidative stress, neurodegeneration, vascular impairments (e.g. blood brain barrier dysfunction), and altered cognitive-behavioral performance. While the clinical significance of methylphenidate treatment in AD patients may be unclear, studies over longer periods of time including testing on animal models will help us understand how methylphenidate treatment can affect our brain activity in the long term and how it can be administered more safely and effectively.