Digital Commons Network^™

A Method For Developing In-Silico Protein Homologs, Susan Mcclatchy

Theses

Computational methods for identifying and screening the most promising drug receptor candidates in the human genome are of great interest to drug discovery researchers. Successful methods will accurately identify and narrow the field of potential drug receptor candidates. This study details one such method.

The method described here begins with the assumption that novel drug receptors have high sequence similarity to established drug receptors. The similarity search program FASTA3 aligns translated sequences of the human genome to known drug receptor sequences and ranks these alignments by measuring their statistical significance. Query results returned by FASTA3 are assembled into "in-silico proteins" …

Functional Annotation And Dendrogram Representation Of Gene Expression Clustering Results, Antoneta Petkova Vladimirova

Theses

The advances in genomic sciences have created vast amounts of gene expression data. To make sense of the expression information, various techniques have been applied. Clustering is among the unsupervised methods used to group the results according to gene expression level. Dendrogram visualization allows graphical representation of the clustering. The aim of this thesis is to enhance these techniques by adding another layer of functionality, namely, annotating the dendrogram with gene functional information. Presented is an application which visualizes yeast clustering results as a dendrogram along with color-coded gene keyword annotations. Gene keyword information was extracted from a major biological …

Liquid-Liquid Mixing In Stirred Tanks With Varying Liquid Depths, Sunil Mehta

Theses

Considerable attention has been devoted in the past to the determination of the minimum agitation speed, N_cd, required for the complete dispersion of two immiscible liquids in mechanically stirred tanks. When this situation is achieved the dispersed phase is no longer present as a distinct layer, such as a light oil phase above an aqueous solution, but becomes completely dispersed, in the form of droplets, throughout the continuous phase. The achievement of the dispersed state is of significant importance in many industrial operations. Nevertheless, the effect on N_cd of a number of operating variables remains poorly understood. …

Integrating Tolerances In G And M Codes Using Neural Networks, Vijay Kumar Sundareshan

Theses

Continuous integrated solutions from CAD down to the preparation of NC programs were developed in the recent years. However, if tolerances should be considered, the interaction of human experts is still necessary. A way to fill this gap in the production process is shown in this thesis. The study builds a relationship between the given design tolerances and including these tolerances in machining by generating respective G and M codes. The study focuses on physical phenomena and their inter-relationship while manufacturing. For example how the speed of machining, torque, power, depth of cut, etc. influences machining under specified tolerances. Artificial …

Njit 2003 Baseball Media Guide, New Jersey Institute Of Technology Athletic Department

Baseball

No abstract provided.

Interaction Of Disparity And Accommodative Vergence, Michele Liu Kung

Theses

To fixate on a target that moves from far to near, changes in blur and disparity activate accommodation and disparity vergence. The goal of this study was to experimentally obtain eye movement data from four subjects, and analyze this data using through a new signal processing algorithm known as independent component analysis (ICA). Preliminary data suggest that three underlying neural subcomponents are present where the two components of disparity vergence initiate the movement and the accommodative portion is activated to facilitate the steady state portion of the response.

ICA was used as a blind source separation technique to analyze experimental …

Njit Highlanders Men's Basketball 2002-03 Media Guide, New Jersey Institute Of Technology Athletic Department

Basketball - Men's

No abstract provided.

Njit Highlanders Women's Basketball 2002-03 Media Guide, New Jersey Institute Of Technology Athletic Department

Basketball - Women's

No abstract provided.

Njit Highlanders Men's Soccer 2002 Media Guide, New Jersey Institute Of Technology Athletic Department

Soccer - Men's

No abstract provided.

Adaptive Ds-Cdma Multiuser Detection For Time Variant Frequency Selective Rayleigh Fading Channel, Xin Tang

Dissertations

The current digital wireless mobile system such as IS-95, which is based on direct sequence Code Division Multiple Access (DS-CDMA) technology, will not be able to meet the growing demands for multimedia service due to low information exchanging rate. Its capacity is also limited by multiple accessed interference (MAI) signals.

This work focuses on the development of adaptive algorithms for multiuser detection (MUD) and interference suppression for wideband direct sequence code division multiple access (DS-CDMA) systems over time-variant frequency selective fading channels. In addition, channel acquisition and delay estimation techniques are developed to combat the uncertainty introduced by the wireless …

Em-Based Iterative Channel Estimation And Sequence Detection For Space-Time Coded Modulation, Zbigniew Baranski

Dissertations

Reliable detection of signals transmitted over a wireless communication channel requires knowledge of the channel estimate. In this work, the application of expectationmaximization (EM) algorithm to estimation of unknown channel and detection of space-time coded modulation (STCM) signals is investigated. An STCM communication system is presented which includes symbol interleaving at the transmitter and iterative EM-based soft-output decoding at the receiver. The channel and signal model are introduced with a quasi-static and time-varying Rayleigh fading channels considered to evaluate the performance of the communication system. Performance of the system employing Kalman filter with per-survivor processing to do the channel estimation …

Resonances Of Periodic Metal-Dielectric Structures At The Infrared Wavelength Region, Oren Sternberg

Dissertations

Metal meshes have been used as reflectors in radar receivers for wavelength much longer than the periodic constant of the conducting wires and as optical reflectors in a FabryPerot in the far infrared. Cross shaped metal meshes can be used as band pass filters but the design theory and near field properties have not been known.

Transmittance of thin, single-layer and multiplayer metal meshes has been investigated using Micro-Strips, yielding numerical solutions of Maxwell's equations. The near field effect was studied for two alignment configurations of cross shaped metal meshes, both free standing and with dielectrics, and transmission line theory …

Thermal Treatment Of Organic Contaminated Solids And Waste : Experiment, Model And Mass Balance, Hsien-Tsung Chern

Dissertations

A number of processes can be used to remediate contaminated soils. The thermal technologies for remediation of contaminated soils are summarized in this study. Each of these treatment process along with their system components are identified and described. Waste applicability is included for each treatment technology. A detailed list of feasible treatment processes is presented with descriptions of site demonstration results to aid ill selection of a given process. Technology status is summarized to provide current information on the processes.

Energy components are discussed for cost requirement and safety considerations in thermal treatment applications. It is determined that the heat …

A Microfabricated Microconcentrator For Sensors And Chromatography, Minhee Kim

Dissertations

The detection and quantitative measurement of trace components is a challenging task. The key component in such an instrument is the concentration step where the analytes are accumulated before the analysis. In this research, simple and inexpensive processes for the microfabrication of microconcentrator that can be used with sensors and as an injector in GC were developed. Analytes are selectively concentrated in the microconcentrator. Rapid electrical heating of the microconcentrator releases the adsorbed species as a 66 concentration pulse", which serves as an injection for the detection system. The relatively small size of the microconcentrator allows it to be heated …

Development Of Membrane Extraction Techniques For Water Quality Analysis, Dawen Kou

Dissertations

This research involved the development of membrane-based analytical techniques as applied to various aspects of water quality analysis. Gas injection membrane extraction was developed for fast on-line analysis of volatile organic compounds in water. Gas injection of aqueous samples increased the speed of membrane extraction. The aqueous boundary layer effects encountered during water elution was reduced. Axial mixing of the sample with a gaseous eluent was minimal, and this eliminated the tailing in the permeation profiles. The overall effect was significantly faster penneation. The overall diffusion coefficient during gas injection was found to be seven times the value during aqueous …

Catalytic Reduction Of Nitric Oxide By Solid Carbonaceous Material Under Lean Condition, Shan Xiao

Dissertations

The reactions of O₂, NO_x and soot from Diesel exhaust over Cu containing catalysts can significantly reduce soot and NO_x emissions while producing N₂ and CO₂. The author has evaluated the performance of Cu ion exchanged ZSM-5 and Cu adsorbed on Granulated Activated Carbon (Cu-GAC) using GAC as a surrogate for soot in a packed bed reactor. CO, formed primarily by the oxidation of GAC with O₂, appears to be a stable intermediate in the reduction of NO. With experimental parameters chosen to simulate Diesel exhaust conditions, Cu-GAC is much more …

Knowledge Discovery And Modeling In Genomic Databases, Michael M. Yin

Dissertations

This dissertation research is targeted toward developing effective and accurate methods for identifying gene structures in the genomes of high eukaryotes, such as vertebrate organisms. Several effective hidden Markov models (HMMs) are developed to represent the consensus and degeneracy features of the functional sites including protein-translation start sites, mRNA splicing junction donor and acceptor sites in vertebrate genes. The HMM system based on the developed models is fully trained using an expectation maximization (EM) algorithm and the system performance is evaluated using a 10-way cross-validation method. Experimental results show that the proposed HMM system achieves high sensitivity and specificity in …

Formation & Characterization Of P/N Shallow Junctions In Sub-Micron Mosfets, Samrat G. Chawda

Theses

The formation of shallow junctions in the source and drain regions is a major challenge to the continued success of scaling of complementary metal oxide semiconductors (CMOS) circuits. The formation of these device structures requires low-energy ion implantation and rapid thermal annealing (RTA). One of the processes which has been shown to be advantageous is spike annealing, with fast ramping and short dwell time at maximum temperature. This work is a study of the effects of implant energy, implant dose and annealing cycles on the reverse-bias leakage current in the diode junction. The reversebias leakage is the study of junction …

On Chip Implement Of Deadlock Avoidance In Wormhole Networks, Kiran K. Gururaj

Theses

This thesis gives a detailed description of the Application Specific Integrated Circuit (ASIC) design to avoid deadlocks in Wormhole Networks. Deadlock avoidance is the most critical issue while considering wormhole networks and should be avoided by any routing protocol and algorithm. A novel architecture for the Turn Prohibition Based Routing (TPBR) protocol has been proved to be efficient and was developed as a part of this work. This architecture for implementing the algorithm is divided into three parts. The first part determines the order of selccuon of the nodes, in the network to run the algorithm. The second part deals …

Quantitative Assessment Of Reflex Blood Pressure Regulation Using A Dynamic Model Of The Cardiovascular System, Tanha Patel

Theses

A quantitative understanding of the changes in coronary, pulmonary and systemic hemodynamic variables and their effects on the regulation mechanism is important to the better postoperative management of patients with impaired cardiac function. The arterial baroreflex plays a key role in blood pressure homeostasis, and its impairment may result in exaggerated blood pressure fluctuations and an increased risk of cardiovascular morbid events.

The objective of this work was to construct a mathematical model of the cardiovascular system, which will allow us to simulate the effects of the baroreceptor reflex regulation on sudden changes in blood pressure, caused by sudden changes …

An Algorithm For Estimating The Quality Of Microarrays, Ajeet S. Sodhi

Theses

Microarray technology is currently one of the most valuable gene expression tools in molecular biology allowing the experimenter to simultaneously quantify the expression of thousands of genes. It is also one of the most difficult tools to use accurately as each microarray produces a large amount of information that needs to be inspected and normalized before analysis. As the size of a microarray or number of replicates increase, the use of manual inspection becomes impractical. The aim of this thesis is to introduce an algorithm that evaluates each feature of a microarray from the scanned data file. A quality score …

Intramural, Collaborative Learning Systems, Robert S. Friedman

Theses

This thesis focuses on three related concepts: problem-based collaborative learning; the use of multimedia tools in learning systems; and participatory design as a software engineering methodology to create multimedia tools to be used in learning systems. A literature review of the three areas is followed by an overview of the pedagogical, technological, and business trends that affect the direction of innovation in education, including problem-based learning. A discussion of a software engineering project to develop a multimedia application that enhances the learning of geography skills and puts the programming, interface design and multimedia systems capabilities of college students into action …

Protection And Restoration Algorithms For Wdm Optical Networks, Pitipatana Sakarindr

Theses

Currently, Wavelength Division Multiplexing (WDM) optical networks play a major role in supporting the outbreak in demand for high bandwidth networks driven by the Internet. It can be a catastrophe to millions of users if a single optical fiber is somehow cut off from the network, and there is no protection in the design of the logical topology for a restorative mechanism. Many protection and restoration algorithms are needed to prevent, reroute, and/or reconfigure the network from damages in such a situation. In the past few years, many works dealing with these issues have been reported. Those algorithms can be …

Probability Of A Hazardous Material Truck Accident In New Jersey, Mahesh Damodaran

Theses

Accident prediction modeling is a powerful tool for determining the frequency of accidents under certain circumstances. Nationwide, direct damages from highway hazardous material spills for the year 2000 were tallied at over $31billion. This thesis determines the probability of an accident involving hazardous materials on the roads of New Jersey. The methodology is based on a British predictive equation used by their Highways Agency to determine the probability of a hazardous spill over a section of a roadway. The parameters used by the British's Highways Agency, which is obtained from their accident data, were modified to reflect conditions that best …

Statistical Image Analysis Of Spotted Arrays, Filippo Posta

Theses

There is a lot of systematic and specific variability in microarray experiments, this variability affects measured gene expression levels, leading to unreliable gene profiling or an heavy load of extra experiment to statistically confirm the data observed in one experiment.

The aim of this work is to systematically analyze, using statistics, the image derived from a cDNA microarray experiment to have a better understanding of this variability and thus a better confidence over the data obtained from an experiment.

Using technologies available at the Center for Applied Genomics, Newark, New Jersey. Selected images derived from different type of microarray experiments …

Masseter Muscle Activity Resulting From Stimulation Of Hypothalamic Behavioral Sites : Wavelet Analysis, Anne Marie Petrock

Theses

Patterns of electromyographic (EMG) activity can give an insight into muscle activity associated with a given behavioral state. The masseter muscle is positioned closely to the temporomandibular joint and controls the position and movement of the jaw. The hypothalamus is the region of the brain associated with emotional behavior. In an effort to further understand the muscle activity underlying emotional display, the hypothalamus in two cats was stimulated to evoke a stereotyped emotional response, known as the "rage response." Unsheathing of the claws, retraction of the ears, significant pupillary dilation and vocalization (hissing) characterize this behavior. EMG data obtained at …

Crystallographic Structure And Mechanical Properties Of Tantalum Coatings On Steel Deposited By Dc Magnetron Sputtering, Charanjeet Singh Paur

Theses

Tantalum metal exhibits excellent erosion and corrosion resistance property. Hence, tantalum coatings are investigated for protection of steel surface exposed to mechanical stresses, high temperature, and corrosive environment. Such conditions exist inside large army gun barrels. The goal of this work was to contribute to the development of technology for tantalum coating of steel, which would replace the presently used electrochemical chromium deposition. A DC magnetron sputtering process was used to deposit tantalum coatings on steel substrates. In sputtering, tantalum is deposited in two phases: ductile, body-centered cubic (bcc) phase (a-phase) and a metastable, brittle tetragonal ß-phase. Only a-phase of …

Formation And Characterization Of N/P Shallow Junctions In Sub-Micron Mosfets, Sridhar Madishetty

Theses

Semiconductors are the burgeoning industries in today's information age. Silicon based microelectronic devices are shrinking day-by-day in accord with the scaling dimensions reported by the International Technology Roadmap for Semiconductors (ITRS). There have been many semiconductor models and simulation programs constantly keeping pace with the continuously evolving scaling dimensions, process technology, performance and cost. Electrical characterization plays a vital role in determining the electrical properties of materials and device structures. Silicon based Metal Oxide Semiconductor Field Effect Transistor (MOSFET) forms the basis of Complimentary Metal Oxide Semiconductor (CMOS) circuits. Today's aggressive scaling approaches in silicon Integrated Circuit (IC) technology require …

Njit Highlanders Women's Volleyball 2002 Media Guide, New Jersey Institute Of Technology Athletic Department

Volleyball - Women's

No abstract provided.

Bi-Axially Loaded Slender Reinforced Concrete Columns Subjected To Sustained Loads, Song Gu

Dissertations

A generalized analytical approach is presented in this research to predict the behavior both of slender and short reinforced concrete columns under sustained biaxial eccentric load.

The present analysis proposes equations established at a cross section of a reinforced concrete column by combining force equilibrium, constitutive law, and compatibility conditions. The strain and curvature of each section and the deflection of the column can then be obtained and resolved.

The established creep computation models, recommended separately by American Concrete Institute (ACI) 209R-92 and the Comite' Euro-International du Be'ton (CEB)-FIP 1990 Model Code have been used to calculate creep and shrinkage …