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Gfsa Encodes A Novel Galactofuranosyltransferase Involved In Biosynthesis Of Galactofuranose Antigen Of O-Glycan In Aspergillus Nidulans And Aspergillus Fumigatus, Yuji Komachi, Shintaro Hatakeyama, Haruka Motomatsu, Taiki Futagami, Karina Kizjakina, Pablo Sobrado, Keisuke Ekino, Kaoru Takegawa, Masatoshi Goto, Yoshiyuki Nomura, Takuji Oka Dec 2013

Gfsa Encodes A Novel Galactofuranosyltransferase Involved In Biosynthesis Of Galactofuranose Antigen Of O-Glycan In Aspergillus Nidulans And Aspergillus Fumigatus, Yuji Komachi, Shintaro Hatakeyama, Haruka Motomatsu, Taiki Futagami, Karina Kizjakina, Pablo Sobrado, Keisuke Ekino, Kaoru Takegawa, Masatoshi Goto, Yoshiyuki Nomura, Takuji Oka

Chemistry Faculty Research & Creative Works

Summary: The cells wall of filamentous fungi in the genus Aspergillus has galactofuranose (Galf)-containing polysaccharides and glycoconjugates, including O-glycans, N-glycans, fungal-type galactomannan and glycosylinositolphosphoceramide, which are important for cell wall integrity. Here, we attempted to identify galactofuranosyltransferases that couple Galf monomers onto other wall components in Aspergillus nidulans. Using reverse-genetic and biochemical approaches, we identified that the AN8677 gene encoded a galactofuranosyltransferase, which we called GfsA, involved in Galf antigen biosynthesis. Disruption of gfsA reduced binding of β-Galf-specific antibody EB-A2 to O-glycosylated WscA protein and galactomannoproteins. The results of an in-vitroGalf antigen synthase assay revealed that GfsA has β1,5- or …


Smart Rocks And Wireless Communication System For Real-Time Monitoring And Mitigation Of Bridge Scour -- A Proof-Of-Concept Study, Genda Chen, David Pommerenke, Y. Rosa Zheng, Andriy V. Radchenko, Yan Tang, Brandon P. Schafer, Ying Huang, Z. L. Yang Dec 2013

Smart Rocks And Wireless Communication System For Real-Time Monitoring And Mitigation Of Bridge Scour -- A Proof-Of-Concept Study, Genda Chen, David Pommerenke, Y. Rosa Zheng, Andriy V. Radchenko, Yan Tang, Brandon P. Schafer, Ying Huang, Z. L. Yang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This study aims to integrate commercial measurement and communication components into a scour monitoring system with magnets or electronics embedded in smart rocks, and evaluate and improve its performance in laboratory and field conditions for the movement of smart rocks. Properly-designed smart rocks were found to be automatically rolled into the very bottom of a scour hole and can give critical information about the maximum scour depth and effectiveness of rip-rap mitigation strategies. Four types of smart rock technologies were investigated in this proof-of-concept phase of study, including passive with embedded magnets, active with magneto-inductive communication, active with controllable magnet …


Efficient Privacy-Preserving Range Queries Over Encrypted Data In Cloud Computing, Bharath K. Samanthula, Wei Jiang Dec 2013

Efficient Privacy-Preserving Range Queries Over Encrypted Data In Cloud Computing, Bharath K. Samanthula, Wei Jiang

Computer Science Faculty Research & Creative Works

With the growing popularity of data and service outsourcing, where the data resides on remote servers in encrypted form, there remain open questions about what kind of query operations can be performed on the encrypted data. In this paper, we focus on one such important query operation, namely range query. One of the basic security primitives that can be used to evaluate range queries is secure comparison of encrypted integers. However, the existing secure comparison protocols strongly rely on the encrypted bit-wise representations rather than on pure encrypted integers. Therefore, in this paper, we first propose an efficient method for …


Differences In Internet Usage Patterns With Stress And Anxiety Among College Students, Levi Malott, Sai Preethi Vishwanathan, Sriram Chellappan Dec 2013

Differences In Internet Usage Patterns With Stress And Anxiety Among College Students, Levi Malott, Sai Preethi Vishwanathan, Sriram Chellappan

Computer Science Faculty Research & Creative Works

Stress and Anxiety negatively affect mental health and can lead a number of debilitating impacts to overall health and wellbeing. In the recent past, adolescents are becoming increasingly afflicted with Stress and Anxiety. In this paper, we report our findings on a six-week study of 70 students at a college campus on associations between Stress and Anxiety with respect to Internet usage of students. Using Cisco NetFlow records, on-campus Internet usage of students was collected continuously and unobtrusively in a privacy-preserving manner. Using the Depression Anxiety and Stress Scale (DASS), students were separated based on normal scores and high scores …


Chc-Tscm: A Trustworthy Service Composition Method Based On An Improved Chc Genetic Algorithm, Cao Buqing, Liu Jianxun, Xiaoqing Frank Liu, Li Bing, Zhou Dong Dec 2013

Chc-Tscm: A Trustworthy Service Composition Method Based On An Improved Chc Genetic Algorithm, Cao Buqing, Liu Jianxun, Xiaoqing Frank Liu, Li Bing, Zhou Dong

Computer Science Faculty Research & Creative Works

Trustworthy service composition is an extremely important task when service composition becomes infeasible or even fails in an environment which is open, autonomic, uncertain and deceptive. This paper presents a trustworthy service composition method based on an improved Cross generation elitist selection, Heterogeneous recombination, Cataclysmic mutation (CHC) Trustworthy Service Composition Method (CHC-TSCM) genetic algorithm. CHC-TSCM firstly obtains the total trust degree of the individual service using a trust degree measurement and evaluation model proposed in previous research. Trust combination and computation then are performed according to the structural relation of the composite service. Finally, the optimal trustworthy service composition is …


Liquid Phase Stability Under An Extreme Temperature Gradient, Zhi Liang, Kiran Sasikumar, Pawel Keblinski Nov 2013

Liquid Phase Stability Under An Extreme Temperature Gradient, Zhi Liang, Kiran Sasikumar, Pawel Keblinski

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Using Nonequilibrium Molecular Dynamics Simulations, We Subject Bulk Liquid to a Very High-Temperature Gradient and Observe a Stable Liquid Phase with a Local Temperature Well above the Boiling Point. Also, under This High-Temperature Gradient, the Vapor Phase Exhibits Condensation into a Liquid at a Temperature Higher Than the Saturation Temperature, Indicating that the Observed Liquid Stability is Not Caused by Nucleation Barrier Kinetics. We Show that, Assuming Local Thermal Equilibrium, the Phase Change Can Be Understood from the Thermodynamic Analysis. the Observed Elevation of the Boiling Point is Associated with the Interplay between the "Bulk" Driving Force for the Phase …


Collaborative Competitive Intelligence: A Knowledge Base System Approach, Yu Liang Chi, Tsang Yao Chen Nov 2013

Collaborative Competitive Intelligence: A Knowledge Base System Approach, Yu Liang Chi, Tsang Yao Chen

Business and Information Technology Faculty Research & Creative Works

This study develops a collaborative decision support system to enhance the enterprise competitive intelligence (CI) decision process. A CI knowledge model is constructed by identifying concepts of and relations among instance types, decision models, rules of thumb, and weighting of organization functions. The system consists of: 1) a Domain Ontology of concepts and instances to express the knowledge categorization structure; 2) a Task Ontology to express an objective-oriented knowledge framework to express the combination of questions; and 3) Semantic Rules to develop the logical steps for problem solving. The case experiment results of high Decision Correctness Rate and Departmental Weighting …


Rethinking Library Instruction: Using Learning Outcome Based Design To Teach Online Search Strategies, Meagan Lacy, Hsin-Liang Chen Nov 2013

Rethinking Library Instruction: Using Learning Outcome Based Design To Teach Online Search Strategies, Meagan Lacy, Hsin-Liang Chen

University Libraries Faculty Research & Creative Works

Given the growing pressure on academic institutions and, by extension, academic libraries to establish student learning outcomes and demonstrate their impact on student learning, researchers at Indiana University – Purdue University Indianapolis (IUPUI) explored how outcome-based instructional design can be used to 1) collect student data, 2) assess student learning, and 3) improve instruction. Two surveys were distributed to 59 undergraduate students who were enrolled in an introductory composition course at IUPUI. Because previous studies (e.g. Ford, Miller and Moss 2005) have linked human individual differences with web search strategy, the first survey collected information about the students’ demographic features. …


The Missouri Miner, November 21, 2013 Nov 2013

The Missouri Miner, November 21, 2013

The Missouri Miner Newspaper

No abstract provided.


Effect Of Fly Ash Replacement Level On The Shear Strength Of High-Volume Fly Ash Concrete Beams, Mahdi Arezoumandi, Jeffery S. Volz Nov 2013

Effect Of Fly Ash Replacement Level On The Shear Strength Of High-Volume Fly Ash Concrete Beams, Mahdi Arezoumandi, Jeffery S. Volz

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The production of Portland cement - the key ingredient in concrete - generates a significant amount of carbon dioxide. However, due to its incredible versatility, availability, and relatively low cost, concrete is the most consumed manmade material on the planet. One method of reducing concrete's contribution to greenhouse gas emissions is the use of fly ash to replace a significant amount of the cement. An experimental investigation was conducted to study the shear strength of full-scale beams constructed with high-volume fly ash concrete (HVFAC) - concrete with at least 50% of the cement replaced with fly ash - and conventional …


Faculty Senate Minutes November 14, 2013, Missouri University Of Science And Technology Faculty Senate Nov 2013

Faculty Senate Minutes November 14, 2013, Missouri University Of Science And Technology Faculty Senate

Minutes & Agendas

No abstract provided.


The Missouri Miner, November 14, 2013 Nov 2013

The Missouri Miner, November 14, 2013

The Missouri Miner Newspaper

No abstract provided.


N-Body:Many-Body Qm:Qm Vibrational Frequencies: Application To Small Hydrogen-Bonded Clusters, J. Coleman Howard, Gregory S. Tschumper Nov 2013

N-Body:Many-Body Qm:Qm Vibrational Frequencies: Application To Small Hydrogen-Bonded Clusters, J. Coleman Howard, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

We present an efficient method for reproducing CCSD(T) (i.e., the coupled-cluster method with single, double and perturbative connected triple excitations) optimized geometries and harmonic vibrational frequencies for molecular clusters with the N-body:Many-body QM:QM technique. In this work, all 1-body through N-body interactions are obtained from CCSD(T) computations, and the higher-order interactions are captured at the MP2 level. The linear expressions from the many-body expansion facilitate a straightforward evaluation of geometrical derivative properties (e.g., gradients and Hessians). For (H2O)n clusters (n = 3-7), optimized structures obtained with the 2-body:Many-body CCSD(T):MP2 method are virtually identical to CCSD(T) optimized geometries. …


Examination Of Tyrosine/Adenine Stacking Interactions In Protein Complexes, Kari L. Copeland, Samuel J. Pellock, James R. Cox, Mauricio L. Cafiero, Gregory S. Tschumper Nov 2013

Examination Of Tyrosine/Adenine Stacking Interactions In Protein Complexes, Kari L. Copeland, Samuel J. Pellock, James R. Cox, Mauricio L. Cafiero, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

The π-stacking interactions between tyrosine amino acid side chains and adenine-bearing ligands are examined. Crystalline protein structures from the protein data bank (PDB) exhibiting face-to-face tyrosine/adenine arrangements were used to construct 20 unique 4-methylphenol/N9-methyladenine (p-cresol/9MeA) model systems. Full geometry optimization of the 20 crystal structures with the M06-2X density functional theory method identified 11 unique low-energy conformations. CCSD(T) complete basis set (CBS) limit interaction energies were estimated for all of the structures to determine the magnitude of the interaction between the two ring systems. CCSD(T) computations with double-ζ basis sets (e.g., 6-31G*(0.25) and aug-cc-pVDZ) indicate that the MP2 method overbinds …


Relating Ph And Ion Release From Ga2o3-Na 2o-Cao-Zno-Sio2 Bioactive Glasses, T. J. Keenan, A. W. Wren, A. Coughlan, Mark R. Towler, M. M. Hall Nov 2013

Relating Ph And Ion Release From Ga2o3-Na 2o-Cao-Zno-Sio2 Bioactive Glasses, T. J. Keenan, A. W. Wren, A. Coughlan, Mark R. Towler, M. M. Hall

Chemical and Biochemical Engineering Faculty Research & Creative Works

Three glasses were designed for this study, including one Ga-free glass (Control), and two Ga-containing glasses (TGa-1, TGa-2). In the Ga-containing glasses, Ga2O3 is included at the expense of ZnO. This study focuses on the relation between pH and ion concentration present in solution in which these bioactive glasses have been submerged for periods of 1, 7, and 14 days. © 2013 IEEE.


An Investigation Into The Structure And Properties Of Cao-Zno-Sio 2-Tio2-Na2o Bioactive Glass/Hydroxyapatite Composite, Chokchai Yatongchai, Mark R. Towler, Anthony W. Wren Nov 2013

An Investigation Into The Structure And Properties Of Cao-Zno-Sio 2-Tio2-Na2o Bioactive Glass/Hydroxyapatite Composite, Chokchai Yatongchai, Mark R. Towler, Anthony W. Wren

Chemical and Biochemical Engineering Faculty Research & Creative Works

Effect of the addition of CaO-ZnO-SiO2-TiO2-Na2O glass as a reinforcing phase on properties of hydroxyapatite/glass composites was investigated. The addition of the glass caused the decomposition of HA phase to tricalcium phosphate, inhibiting densification in the HA/glass composites. However, depending on the glass concentration, some of the glass can act as a sintering aid enhancing the densification in the composites. © 2013 IEEE.


Role Of Ser-257 In The Sliding Mechanism Of Nadp(H) In The Reaction Catalyzed By The Aspergillus Fumigatus Flavin-Dependent Ornithine N ⁵-Monooxygenase Sida, Carolyn Shirey, Somayesadat Badieyan, Pablo Sobrado Nov 2013

Role Of Ser-257 In The Sliding Mechanism Of Nadp(H) In The Reaction Catalyzed By The Aspergillus Fumigatus Flavin-Dependent Ornithine N ⁵-Monooxygenase Sida, Carolyn Shirey, Somayesadat Badieyan, Pablo Sobrado

Chemistry Faculty Research & Creative Works

SidA (siderophore A) is a flavin-dependent N-hydroxylating monooxygenase that is essential for virulence in Aspergillus fumigatus. SidA catalyzes the NADPH- and oxygen-dependent formation of N5-hydroxyornithine. In this reaction, NADPH reduces the flavin, and the resulting NADP+ is the last product to be released. The presence of NADP+ is essential for activity, as it is required for stabilization of the C4a-hydroperoxyflavin, which is the hydroxylating species. As part of our efforts to determine the molecular details of the role of NADP(H) in catalysis, we targeted Ser-257 for site-directed mutagenesis and performed extensive characterization of the S257A enzyme. Using a combination of …


Biocompatibility Of Cao-Na2o-Sio2/Tio2 Glass Ceramic Scaffolds For Orthopaedic Applications, A. W. Wren, A. Coughlan, K. E. Smale, S. T. Misture, B. P. Mahon, O. M. Clarkin, Mark R. Towler Nov 2013

Biocompatibility Of Cao-Na2o-Sio2/Tio2 Glass Ceramic Scaffolds For Orthopaedic Applications, A. W. Wren, A. Coughlan, K. E. Smale, S. T. Misture, B. P. Mahon, O. M. Clarkin, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

This work aims to determine the effect of substituting TiO2 for SiO2 in a 0.62SiO2-Na2O-0.24CaO based glass-ceramic scaffold. High temperature X-ray Diffraction (HT-XRD) was used to determine the sintering temperature (700oC). Both optical microscopy and x-ray micotomography was used to determine the average pore size (540-680ìm) of each scaffold. Cytocompatibility of each scaffold was conducted using murine mesenchymal stem cells. © 2013 IEEE.


Gallium Containing Glass Polyalkenoate Bone Cements: Ion Release And E. Coli Inhibition, L. Placek, A. W. Wren, A. Coughlan, Mark R. Towler Nov 2013

Gallium Containing Glass Polyalkenoate Bone Cements: Ion Release And E. Coli Inhibition, L. Placek, A. W. Wren, A. Coughlan, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

The Glass Polyalkenoate Cement (GPC) series (LCon., LGa-1 and LGa-2) containing gallium (Ga) and a 50 wt% addition of E11 polyacrylic acid (PAA), previously developed, was evaluated for ion release, specifically Si, Ca, Zn and Ga, and E. coli inhibition. The maximum inhibition was observed in the t = 0 samples and was 0.35 mm for LCon. and 0.65 mm for LGa-1 and LGa-2. © 2013 IEEE.


The Missouri Miner, November 7, 2013 Nov 2013

The Missouri Miner, November 7, 2013

The Missouri Miner Newspaper

No abstract provided.


2013 Scholarly Productivity Report, Missouri University Of Science And Technology Nov 2013

2013 Scholarly Productivity Report, Missouri University Of Science And Technology

Civil, Architectural and Environmental Engineering Scholarly Productivity Reports

No abstract provided.


Extreme Learning Machines, Erik Cambria, Guang Bin Huang, Liyanaarachchi Lekamalage Chamara Kasun, Hongming Zhou, Chi Man Vong, Jiarun Lin, Jianping Yin, Zhiping Cai, Qiang Liu, Kuan Li, Victor C.M. Leung, Liang Feng, Yew Soon Ong, Meng Hiot Lim, Anton Akusok, Amaury Lendasse, Francesco Corona Nov 2013

Extreme Learning Machines, Erik Cambria, Guang Bin Huang, Liyanaarachchi Lekamalage Chamara Kasun, Hongming Zhou, Chi Man Vong, Jiarun Lin, Jianping Yin, Zhiping Cai, Qiang Liu, Kuan Li, Victor C.M. Leung, Liang Feng, Yew Soon Ong, Meng Hiot Lim, Anton Akusok, Amaury Lendasse, Francesco Corona

Engineering Management and Systems Engineering Faculty Research & Creative Works

No abstract provided.


Directed Search For Continuous Gravitational Waves From The Galactic Center, J. Aasi, Marco Cavaglia, For Full List Of Authors, See Publisher's Website. Nov 2013

Directed Search For Continuous Gravitational Waves From The Galactic Center, J. Aasi, Marco Cavaglia, For Full List Of Authors, See Publisher's Website.

Physics Faculty Research & Creative Works

We present the results of a directed search for continuous gravitational waves from unknown, isolated neutron stars in the Galactic center region, performed on two years of data from LIGO's fifth science run from two LIGO detectors. The search uses a semicoherent approach, analyzing coherently 630 segments, each spanning 11.5 hours, and then incoherently combining the results of the single segments. It covers gravitational wave frequencies in a range from 78 to 496 Hz and a frequency-dependent range of first-order spindown values down to -7.86 x 10-8 Hz/s at the highest frequency. No gravitational waves were detected. The 90% …


Plasmonic Scaling Of Superconducting Metamaterials, Cihan Kurter, John A. Abrahams, Gennady Shvets, Steven Mark Anlage Nov 2013

Plasmonic Scaling Of Superconducting Metamaterials, Cihan Kurter, John A. Abrahams, Gennady Shvets, Steven Mark Anlage

Physics Faculty Research & Creative Works

Superconducting metamaterials are utilized to study the approach to the plasmonic limit simply by tuning temperature to modify the superfluid density, and thus the superfluid plasma frequency. We examine the persistence of artificial magnetism in a metamaterial made with superconductors in the plasmonic limit, and compare to the electromagnetic behavior of normal metals as a function of frequency as the plasma frequency is approached from below. Spiral-shaped Nb thin film meta-atoms of scaled dimensions are employed to explore the plasmonic behavior in these superconducting metamaterials, and the scaling condition allows extraction of the temperature dependent superfluid density, which is found …


Social Group Detection Based Routing In Delay Tolerant Networks, Roy Cabaniss, Srinivasa S. Vulli, Sanjay Madria Nov 2013

Social Group Detection Based Routing In Delay Tolerant Networks, Roy Cabaniss, Srinivasa S. Vulli, Sanjay Madria

Computer Science Faculty Research & Creative Works

When implementing Mobile Ad Hoc Networks, a key characteristic of the network is the mobility pattern of the nodes. Based on the application, nodes can follow semi-predictable patterns, such as the routes followed by Vehicular Ad Hoc Networks, or the more strict schedules followed by aerial reconnaissance. Optimal routing schemes tend to take advantage of information regarding these patterns. In social environments, such as wildlife tracking or sending messages between humans, the devices and/or users will follow regular contact habits, tending to encounter social groups in which they participate. By identifying these groups, the patterns are used to optimize routing …


Postcyclic Behavior Of Low-Plasticity Silt With Limited Excess Pore Pressures, Shuying Wang, Ronaldo Luna, Junsheng Yang Nov 2013

Postcyclic Behavior Of Low-Plasticity Silt With Limited Excess Pore Pressures, Shuying Wang, Ronaldo Luna, Junsheng Yang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This paper investigates the post cyclic behavior of low-plasticity silt with excess pore pressure ratio (Ru) less than 1. The testing specimens were prepared from Mississippi River Valley (MRV) silt. Full and no reconsolidation were allowed after specimens were subjected to various excess pore pressure ratios due to cyclic loading in a cyclic triaxial cell, and then monotonic shear tests were conducted. The effect of the Ru on shear strength and stiffness at small and large deformation was investigated. It was found that a Ru greater than 0.70 is a prerequisite of large increase in volumetric strain and undrained shear …


Substrate-Dependent Dynamics Of Udp-Galactopyranose Mutase: Implications For Drug Design, Leonardo Boechi, Cesar Augusto F. De Oliveira, Isabel Da Fonseca, Karina Kizjakina, Pablo Sobrado, John J. Tanner, J. Andrew Mccammon Nov 2013

Substrate-Dependent Dynamics Of Udp-Galactopyranose Mutase: Implications For Drug Design, Leonardo Boechi, Cesar Augusto F. De Oliveira, Isabel Da Fonseca, Karina Kizjakina, Pablo Sobrado, John J. Tanner, J. Andrew Mccammon

Chemistry Faculty Research & Creative Works

Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease that represents one of the major health challenges of the Latin American countries. Successful efforts were made during the last few decades to control the transmission of this disease, but there is still no treatment for the 10 million adults in the chronic phase of the disease. In T. cruzi, as well as in other pathogens, the flavoenzyme UDP-galactopyranose mutase (UGM) catalyzes the conversion of UDP-galactopyranose to UDP-galactofuranose, a precursor of the cell surface b-galactofuranose that is involved in the virulence of the pathogen. The fact that …


A Coaxial Cable Fabry-Perot Interferometer For Sensing Applications, Jie Huang, Tao Wang, Lei Hua, Jun Fan, Hai Xiao, Ming Luo Nov 2013

A Coaxial Cable Fabry-Perot Interferometer For Sensing Applications, Jie Huang, Tao Wang, Lei Hua, Jun Fan, Hai Xiao, Ming Luo

Electrical and Computer Engineering Faculty Research & Creative Works

This paper reports a novel coaxial cable Fabry-Perot interferometer for sensing applications. The sensor is fabricated by drilling two holes half-way into a coaxial cable. The device physics was described. The temperature and strain responses of the sensor were tested. The measurement error was calculated and analyzed.


Mathematical Engineering And Control With Applications, Mamdouh M. El Kady, Martin Bohner, J. Liang, Mouffak Benchohra Oct 2013

Mathematical Engineering And Control With Applications, Mamdouh M. El Kady, Martin Bohner, J. Liang, Mouffak Benchohra

Mathematics and Statistics Faculty Research & Creative Works

No abstract provided.


The Missouri Miner, October 31, 2013 Oct 2013

The Missouri Miner, October 31, 2013

The Missouri Miner Newspaper

No abstract provided.