Digital Commons Network^™

Positive Solutions For Nonlinear Fractional Differential Equations With A Disturbance Parameter On An Infinite Interval, Zhaocai Hao, Lu Song, Martin Bohner, Qianqian Gu, Panzhen Liu

Mathematics and Statistics Faculty Research & Creative Works

This paper studies a class of integral boundary value problems of fractional differential equations with a disturbance parameter on an infinite interval. By applying the upper-lower solution method and fixed point index theory, the influence of the disturbance parameter on the existence of positive solutions is rigorously analyzed. We have obtained that the boundaryvalue problem admits at least twopositive solutions, one positivesolution or no solution. An example is provided to validate the results. The results of this study provide a significant complement and refinement to some existing findings.

Magnetic Field Tuned Magnetic Order And Metamagnetic Criticality In Nonstoichiometric Ceaubi2, Halyna Hodovanets, Hyunsoo Kim, Tristin Metz, Yasuyuki Nakajima, Christopher J. Eckberg, Kefeng Wang, Jie Yong, Shanta R. Saha, David Graf, Nicholas P. Butch, Thomas Vojta, Johnpierre Paglione

Physics Faculty Research & Creative Works

We present a detailed study of magnetization, resistivity, heat capacity, and x-ray and neutron powder diffraction measurements performed on single crystals of nonstoichiometric CeAuBi₂, Au deficiency 18%, a strongly correlated antiferromagnet with Néel temperature T_N = 13.2 K. Field-dependent magnetization measurements reveal a large magnetic anisotropy at low temperatures with an easy axis along the crystallographic c axis, in which direction a spin-flop transition exhibits strong features in magnetization, specific heat, and resistivity at H_c = 75 kOe. The constructed temperature-field phase diagram connects this transition to the suppression of magnetic order, which evolves from a …

A Photosynthetic–Respiratory Electron Transport Chain Chimera Based On Photosystem I And Cytochrome C Oxidase On Graphene Oxide, Xiaoping Zhu, Matthew J. Kummer, Carolyn E. Lubner, Vasily Kurashov, William Carr, John H. Golbeck, Robert A. Niederman, Lev G. Mourokh, Shelley D. Minteer, Paul G. Falkowski, Michele Vittadello

Chemistry Faculty Research & Creative Works

Te self-assembly of enzyme proteins on 2D nanomaterials has enabled the construction and functional control of viable biochemical pathways. However, enzymatic cascades, which combine essential components of the photosynthetic and respiratory electron transport chains in tandem, have thus-far remained elusive. Herein, we have investigated a galvanic biohybrid nano system coupling photosystem I and cytochrome c oxidase on the surface of graphene oxide nanosheets in colloidal suspension. Te oriented immobilization of the enzymes was facilitated by Ni-coordination sites tethered to the carbon basal plane, with negligible parasitic O2 consumption. Transient absorption and electrochemical measurements provided evidence of electron transfer between donors …

Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability …

Rheological Modification Of Alkali-Activated Slag Mortar: Roles Of Sodium Gluconate Retarder And Dispersants, Tae Yong Shin, Seongho Han, Ryong You, Yubin Jun, Jae Hong Kim

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Alkali-activated materials have emerged as promising low-carbon alternatives to ordinary Portland cement-based binders; however, their practical application is strictly limited by rapid setting and poor workability. To address these challenges, this study proposes an evaluation methodology combining setting time measurement, cloud point tests for chemical stability, and wide-range rheological analysis. While conventional superplasticizers like polycarboxylate ether (PCE) proved unstable in high-alkaline environments, cloud point tests revealed that polynaphthalene sulfonate (PNS) and butyl acrylate (BA) exhibited superior chemical stability. Notably, BA was identified as a novel and effective dispersant in 3.5 M KOH-activated systems, reducing yield stress of fresh mortar by …

Hardness Of (Hf,Ti,W,Zr)B2/(Hf,Ti,W,Zr)C-Based Ceramics With Varying Wb Content, Suzana Filipović, William G. Fahrenholtz, Gregory E. Hilmas, Nina Obradović, Stefano Curtarolo

Materials Science and Engineering Faculty Research & Creative Works

Compositionally complex (Hf,Ti,Zr,W)B₂/(Hf,Ti,Zr,W)C-based ceramics were produced with different boride and carbide phase contents by varying the C/B₄C molar ratio used in boro/carbothermal reduction. A monoboride phase based on WB was detected in all compositions. As the C/B₄C ratio was varied, the WB content decreased from 23.7 vol% for a C/B₄C ratio of 6.0–15.3 vol% for a C/B₄C ratio of 10.3. Further increases in the C/B₄C ratio increased the WB content. The monoboride phase contained mainly W and Ti in a solid solution with the nominal composition of (W …

Long-Range Fit: A Software Package For The Representation And Study Of Long-Range Molecular Interactions, Adrian L. Batista-Planas, Ernesto Quintas-Sánchez, Richard Dawes

Chemistry Faculty Research & Creative Works

Describing intermolecular forces is fundamental to modeling and predicting the behavior of molecular systems. In particular, long-range molecular interactions with electrostatic, induction, and dispersion as the main components play a critical role, especially for low-temperature and low-density regimes. Long-range interactions are often described through perturbation theory, representing the electronic charge distribution via a multipolar series of the moments and polarizability tensors corresponding to each molecule. However, while the theory is well established, obtaining the resulting analytical expressions (and their practical implementation) constitutes a highly complex and system-dependent task. To address this challenge, we developed long-range-fit (LRF), an interactive and user-friendly …

Cationic Poly(Glucosamine)-Based Polymers Bind To Glycans With Varying Affinity Facilitating Transport Across The Glycocalyx Of Endothelial Cells, Claire Bridges, Lu Fu, Dan Wang, James D. Sterling, Susanna Liang, Shenda M. Baker, Jonathan Yeow, Megan S. Lord

Business and Information Technology Faculty Research & Creative Works

Natural polysaccharides, such as chitosan, offer promising avenues for drug delivery due to their cytocompatibility and ability to interact with cell surfaces. However, the endothelial glycocalyx, a glycan-rich extracellular matrix, presents a barrier that must be navigated for effective intracellular delivery. This study investigates how cationic poly(glucosamine)-based polymers, functionalized with guanidinium or ammonium groups, interact with key glycocalyx components including hyaluronan (HA) and heparan sulfate (HS). We demonstrate that these cationic polymers form tunable biomolecular condensates with glycans, with stronger binding observed for sulfated glycans, HS and heparin, than unsulfated HA. Derivatized chitosan polymers with varied cationic side chains exhibit …

Early Detection Of Infectious Diseases: A Review Of Recent Advances In Pathogen Identification, Molecular Tools, And Metabolomics-Driven Biomarker Discovery, Patrica Ivy Agorsor, Michael O. Eze

Chemistry Faculty Research & Creative Works

The recent COVID-19 pandemic has heightened public interest in noninvasive methods for early diagnosis of infectious diseases. In addition, various government agencies have implemented "infectious disease preparedness" to mitigate future outbreaks. This review highlights conventional and advanced methods for infectious disease diagnosis with an emphasis on emerging mass spectrometry methods. Conventional methods for pathogen identification, such as culture-based techniques and molecular methods, have limitations with respect to sensitivity, specificity, and turnaround time. Recent advances in high-resolution mass spectrometry have revolutionized the field of infectious disease biomarker discovery. These techniques enable the comprehensive profiling of metabolites in various biological samples, identification …

Probing Proximal Intramolecular Hydrogen Bonding Interactions On A Norbornane Scaffold, Carly A. Rock, Dakota B. Green, Martin J. Flores, Jeremy M. Carr, Thufail M. Ismail, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

A systematic computational study was conducted on 12 unique 2,6-disubstituted norbornane derivatives to assess the ability of various acceptor groups (A = F, Cl, Br, OH, OCH3, SH, SCH3, NHCH3, N(CH3)2, PH2, PHCH3, and P(CH3)2) to engage in intramolecular hydrogen bonding with a proximal OH donor. 32 unique minima have been characterized with M06-2X and df-MP2 geometry optimizations as well as PNO-LCCSD(T)-F12 single point energy computations. Conformations with the OH donor oriented toward the acceptor to form an OH···A contact (+HB) consistently had lower electronic energies (by approximately 2 to 8 kcal mol^–1) than their counterparts with the …

Use Of Gamma-Ray Spectroscopy In Thickness Gauging Of A Complex-Shaped Lead Shield, Joseph T. Graham, Brian Durtschi, Ashish Avachat, Seth Kilby

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

Methods for measuring the thickness of lead shielding based on ⁶⁰Co gamma-ray spectroscopy are presented. In applications where a shield's thickness is multiple mean free paths and the shield has a complex shape (i.e. cannot be approximated as a simple solid such as a slab, sphere, semi-infinite medium, etc.), the necessary buildup factors are not available. Thus, determination of shield thickness by means of the Beer–Lambert law requires separating the counts from uncollided photons from the scattered photon contribution. It is demonstrated how the 1332 keV gamma ray of ⁶⁰Co can be used to precisely quantify lead thicknesses …

Positive Solutions Of Semipositone Singular Three-Points Boundary Value Problems For Nonlinear Fractional Differential Equations, Xueyan Zhang, Zhaocai Hao, Martin Bohner

Mathematics and Statistics Faculty Research & Creative Works

This study introduces the existence of one positive solution for a specific category of semipositive singular three-point boundary value problems associated with Caputo fractional differential equations. The proof relies on the application of the Guo–Krasnosel'skii fixed point theorem. In the end, we provide an illustrative example.

How To Measure, Analyze, And Interpret Age-Related Changes In Caenorhabditis Elegans: Lessons For Mechanistic And Evolutionary Theories Of Aging, Zuzana Kocsisova, Brian M. Egan, Andrea Scharf, Xavier Anderson, Franziska Pohl, Aaron Anderson, Kerry Kornfeld

Biological Sciences Faculty Research & Creative Works

Aging is characterized by progressive degenerative changes in tissue organization and function, some of which increase the probability of mortality. Major goals of aging research are to elucidate the series of events that cause degenerative changes, and to identify environmental, pharmacological, and genetic factors that influence these changes; this information might lead to new strategies to extend health span and lifespan. Mechanistic studies of aging depend on accurate and precise descriptions of age-related changes, since these descriptions define the aging phenotype. Here, we review studies that describe age-related changes in C. elegans, including measurements of integrated functions such as behavior …

A Note On Sufficient Dimension Folding For Regression Mean Function With Categorical Predictors, Bilin Zeng, Akim Adekpedjou, Xuerong Meggie Wen

Mathematics and Statistics Faculty Research & Creative Works

Multi-dimensional arrays are referred to as tensors. Tensor-valued predictors are commonly encountered in modern biomedical applications, such as electroencephalogram (EEG), magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion-weighted MRI, and longitudinal health data. In survival analysis, it is both important and challenging to integrate clinically relevant information, such as gender, age, and disease state along with medical imaging tensor data or longitudinal health data to predict disease outcomes. Most existing higher-order sufficient dimension reduction regressions for matrix- or array-valued data focus solely on tensor data, often neglecting established clinical covariates that are readily available and known to have predictive value. …

Exploring Public Opinions On Mining Governance And Preferences For Interventions To Enhance Battery Mineral Access, Mahelet G. Fikru, Sreeja Koppera, Nhien Nguyen

Economics Faculty Research & Creative Works

Based on an online survey of 1200 individuals, we examine support for new mining projects in the United States, opinions on mining governance, and preferences for various strategies to access battery minerals. We find support for domestic mining more so at the national (54 % support) than local level (32 % support), with a strong emphasis on environmental protection and multi-level governance. Respondents generally support government intervention to secure access to battery minerals, with over half agreeing with subsidizing electric vehicle (EV) producers and consumers to prioritize the use of domestic minerals in EV batteries. However, there is measurable opposition …

Advances And Challenges In Nano-Modified Cementitious Composites: Mechanisms, Dispersion Strategies, And Impact On Mechanical Properties, Fatemeh Mohammadi Ghahsareh, Pengwei Guo, Nusrath Jaha, Yi Bao, Kamal H. Khayat, Weina Meng

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Nanomaterials are increasingly utilized to enhance the mechanical properties, durability, and functionality of concrete materials but face challenges such as agglomeration and uneven dispersion in cementitious systems, which can offset the intended improvements. This paper reviews the advances and challenges associated with nano-modified cementitious composites, elucidating fundamental mechanisms and highlighting strategies for overcoming the challenges through experimental and computing techniques. The reviewed contents include (1) the classification of nanomaterials commonly used in cementitious systems and the mechanisms through which they enhance the mechanical properties of cementitious composites; (2) challenges of nanomaterials such as agglomeration in water, re-agglomeration in cementitious systems, …

Hold Paramount The Health, Safety, And Welfare Of The Public And The Planet, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.

Tip Penetration Test For Rapid In-Line Assessment Of Static Yield Stress During 3d Concrete Printing Process, Ali Fasihi, Nicolas A. Libre

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The static yield stress of printable cementitious materials is a critical parameter governing the shape stability and buildability of 3D printed concrete structures. Among various testing techniques, the penetration test has emerged as a promising method for in-situ measurement of static yield stress during printing process. However, the applicability of the penetration test for in-line monitoring of static yield stress remains limited due to the necessity for substantial material thickness. To address this challenge, this study proposes a novel tip penetration test, which enables static yield stress determination without the requirement for full cone submergence, thereby facilitating assessment of thin …

Rheological And Micro Properties Of High-Viscosity Binder-Incorporated Polyphosphoric Acid And Rock Asphalt, Feng Ma, Xinye Jiang, Zhen Fu, Chongxin Zhu, Jenny Liu, Ke Shi, Yalu Wen, Yao Zhang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

To enhance the performance of high-viscosity modified asphalt (HVMA), polyphosphoric acid (PPA) and North American rock asphalt (NA-RA) were incorporated into styrene-butadiene-styrene (SBS)/crumb rubber (CR) composite modified asphalt, resulting in two distinct types of HVMA. The two HVMA types were evaluated at various dosages using a dynamic shear rheometer (DSR), bending beam rheometer (BBR), fluorescence microscope (FM), and Fourier infrared spectroscopy (FT-IR) tests. These tests provided both macroscopic and microscopic insights into their properties. The findings indicated that both PPA and NA-RA modify the asphalt's internal structure, enhancing its temperature resistance. PPA primarily improved high-Temperature performance, while NA-RA enhanced low-Temperature …

A Rapid Field Moisture Measurement Unit For Compaction Acceptance Of Unbound Materials, Chuanjun Liu, Xiong Zhang, Jenny Liu

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The moisture content (MC) was a critical parameter that needed to be monitored in geomaterial compaction. Nuclear density gauges (NDGs) had been the practice in MC and density measurement for decades but had become less desirable due to cost, regulatory, and safety concerns. Meanwhile, lightweight deflectometers (LWDs), proposed as an alternative to NDGs, did not have a function of MC measurement. This study aimed to identify a rapid field moisture analyzer to work with LWDs for evaluating the compaction acceptance of unbound materials in situ. The study started with evaluating the effectiveness and practicability of two existing moisture analyzers recommended …

Reflections On Linear B (Part 14) – Sign 76 (With Two Parallel Wavy Lines Pronounced /Ra/); Possible Derivation From The River Traveled Nightly By The Sun God Ra., Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

This article suggests that the two parallel wavy lines in Linear B sign 76 depict the river traveled nightly by the Egyptian sun god Ra. Also:

1. The Egyptian influence was likely exerted already on the Linear A and Cretan hieroglyphic antecedents of Linear B sign 76.

2. Variants of Linear B sign 76 contain a horizontal line across the two wavy vertical lines. The present article suggests the horizontal line might indicate one of the river’s twelve gates that Ra had to navigate through in his nightly journey.

3. But the single line for that one gate was likely …

Leveraging Molecular Mechanisms Of Desorption To Enhance Pfas Bioavailability In Contaminated Soils, Husam Kafeenah, Margaret D. Taiwo, Patrica Ivy Agorsor, Michael O. Eze

Chemistry Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFAS) are known for their strong binding properties to soil matrices owing to their amphiphilic properties. While most studies focus on the search for novel PFAS bio degraders, our knowledge of sustainable biomolecules that could drive PFAS desorption and make them more bioavailable is limited. This study investigated the effectiveness of rhamnolipids and organic acids in desorbing PFAS compounds from contaminated soil. Rhamnolipids (25 mg/L) significantly enhanced the release of PFAS compounds from soil, achieving up to 90 % desorption. Acetic acid provided 60–90 % desorption efficiency for most of the PFAS studied, except for PFDA …

Influence Of Wicking Geotextile Installation On Moisture Migration In Silt Under Rainfall Infiltration, Yipeng Guo, Dahao Zou, Min Hu, Xiong Zhang, Fang Xu, Yongjie Zhang, Jiejing Chen

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Silt is widely used in subgrade construction in the middle and lower reaches of the Yellow River in China due to limited availability of high-quality fill. However, its high moisture sensitivity and low strength often lead to pumping, settlement, and deformation. This study investigates the hydraulic performance of a wicking geotextile in silt under simulated rainfall infiltration using one-dimensional soil column experiments. Three installation configurations were evaluated: (i) a control sample (CS) without geotextile, (ii) an embedded sample (ES) with the geotextile fully installed as a capillary barrier, and (iii) a surface-exposed sample (SES) with the geotextile extended to the …

Generative Artificial Intelligence In Aircraft Design Optimization, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Aircraft design optimization is essential for improving aircraft performance (such as reduced fuel consumption and lowered noise), which leads to more efficient, sustainable, and affordable aircraft. Conventional aircraft design adopts physics-based simulation models, but iteratively evaluating simulation models is computationally intensive, or even practically impossible. Meanwhile, artificial intelligence (AI) emerges as a revolutionary game changer in the modern engineering industry, including aircraft design optimization. Generative AI (genAI), one of the groundbreaking AI methods, has been advancing aircraft design optimization from various aspects, including intelligent parameterization, predictive modeling, training facilitation, and constraints handling. However, there is a lack of a review …

Hybrid Sensing For Near-Earth Space Domain Awareness: Leveraging Space-Based Assets For Augmenting Optical Ground Observations, Smriti Nandan Paul, Hang Woon Lee

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Because of recent advancements in space technologies, easier and more economical access to space, and an increase in commercial interests, the near-Earth space environment has witnessed an exploding number of objects being put into orbit. In particular, the low Earth orbit (LEO) region is at an increased risk of orbital collisions from large satellite constellation projects. Thus, monitoring LEO objects for space domain awareness and space traffic management has become increasingly imperative. In this paper, we use the concept of limited-CDF (cumulative distribution function) surface and mutual information for designing sensor tasking algorithms focusing on regular observation of known catalog …

Modeling And Characterizing The Electron Backscatter In A Cylindrical Anode-Based Distributed X-Ray Source, Jordan Fox, Seth Kilby, Hyoung Koo Lee, Ayodeji Alajo, Ashish Avachat

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

Upcoming advancements in computed tomography architectures warrants the investigation of new X-ray source designs and the impacts that electron backscatter can have on these designs. One such design being investigated is a distributed, cylindrical anode-based X-ray source. For such a distributed X-ray source, we developed a modeling pipeline for simulating electron optics and transport to characterize the quality of the primary X-ray beam and the electron backscatter behavior. We report our results on the energy distributions of the bremsstrahlung spectra; electron backscatter ratio; and spatial, temporal, and energy distributions of backscattered electrons that return to the anode.

Full Core Fuel Burnup Assessment Of The Itu Triga Mark Ii Research Reactor Using Gamma Spectroscopy, Z. Boduroglu, A. Kaya, O. Erbay, I. A. Reyhancan, M. S. Kiziltas, T. Akyurek

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

This study investigates the burnup distribution of fuel elements in the ITU TRIGA Mark II research reactor core through gamma spectroscopy using¹³⁷Cs as a burnup indicator. Non-Destructive Assay (NDA) techniques were employed to analyze fuel depletion, utilizing a specialized fuel investigation system installed above the reactor pool. The results indicate that the highest burnup values, exceeding 5 %, were concentrated in the inner core rings (B and C) due to intense neutron flux exposure, while the outer rings (D, E, F) exhibited lower burnup levels. To address this asymmetric distribution, a proposed fuel reshuffling strategy was analyzed, aiming …

Nondestructive Burnup Evaluation And Gamma Spectroscopy Analysis Of Spent Fuel Elements In The Itu Triga Mark Ii Research Reactor, A. Kaya, O. Erbay, Z. Boduroglu, I. A. Reyhancan, M. S. Kiziltas, T. Akyurek

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

This study presents a comprehensive burnup analysis of all fuel elements in the ITU TRIGA Mark II research reactor core using non-destructive assay (NDA) techniques based on gamma spectroscopy. Two distinct fuel inspection systems were employed to measure the gamma activity, with¹³⁷Cs used as the primary burnup indicator due to its strong correlation with fuel depletion. The results show a clear burnup pattern, with higher values in the inner core rings that gradually decreases toward the outer rings. This asymmetric burnup distribution underscores the need for reactor core reconfiguration, for which an optimized layout is proposed. Additionally, gamma …

Integrated Computational And Experimental Investigation Of Groups V And Vi Metals In (M,Hf,Ti,Zr)B2-(M,Hf,Ti,Zr)C Ceramics, Ana C. Feltrin, Simon Divilov, Gregory E. Hilmas, Stefano Curtarolo, William G. Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

Dual-phase compositionally complex ultra-high temperature ceramics were formulated by incorporating different Groups V and VI metals such as V, Nb, Ta, Cr, Mo, or W into a base composition containing the Group IV elements, Hf, Ti, and Zr. Metal distribution was predicted using first-principles-based thermodynamics simulations and compared with experimental results. Moreover, phase stability, microstructure, and mechanical properties were evaluated for all of the ceramics. Compositions containing Cr, V, Nb, or Ta formed dual-phase ceramics containing only one boride and one carbide phase, while compositions containing Mo or W developed an additional third phase. The experimental metal distribution trends generally …

Co-Calcination Of Limestone And Clay Enhances The Performance Of Limestone Calcined Clay Cement (Lc3), Oluwadamilare Charles Adesina, Sahil Surehali, Avinaya Tripathi, Kayla Lauren Lee, Bryan K. Aylas-Paredes, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Limestone-calcined clay cements (LC³) reduce the environmental impact of cement production and accelerate the industry transition toward carbon neutrality. While conventional LC³ with 50% clinker replacement (LC³-50) demonstrate long-term performance comparable to ordinary Portland cement (OPC) in concrete, early-age performance is generally compromised. This study explores for the first time, joint thermal treatment—that is, co-calcination—of limestone (LS) and bulk kaolinitic clay in mass ratios of 1:1 to 1:4 under a calcination regime specifically designed to ensure activation of the clay mineral. The co-calcination converts a small fraction of LS to metastable CaO, thus providing an …