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Articles 631 - 660 of 29124
Full-Text Articles in Entire DC Network
A System Of Systems (Sos) Meta-Architecture Approach To Design Digital Platform-Based Domestic Worker Distribution System, Prithbey Raj Dey, Cihan H. Dagli, David Lee Enke
A System Of Systems (Sos) Meta-Architecture Approach To Design Digital Platform-Based Domestic Worker Distribution System, Prithbey Raj Dey, Cihan H. Dagli, David Lee Enke
Engineering Management and Systems Engineering Faculty Research & Creative Works
In this research, a System of Systems (SoS) meta-architecture is conceptualized to design a digital platform-based system framework for the distribution of domestic workers to boost the crowd-sourced economy. While an Object Process Methodology (OPM) is used to articulate the relationships between the objects and functions, a Design Structure Matrix (DSM) has been applied to address the interactions between individual components to categorize them into subsystems to create the SoS architecture. This SoS architecture incorporates several Key Performance Attributes (KPAs) and Key Performance Parameters (KPPs) to systematically evaluate the meta-architectures. The Analytical Hierarchical Process (AHP), Pugh’s Evaluation Matrix, and Technique …
Blockchain-Based Ai-Assisted Cyber-Physical Systems For Robust And Reliable Machining Processes, Prithbey Raj Dey, David Lee Enke
Blockchain-Based Ai-Assisted Cyber-Physical Systems For Robust And Reliable Machining Processes, Prithbey Raj Dey, David Lee Enke
Engineering Management and Systems Engineering Faculty Research & Creative Works
This study demonstrates the prospects of Blockchain-based Cyber-Physical Systems (CPS) to establish a scalable framework for designing a secured, automated, and traceable modeling in machining processes. Machining operations like turning, being inherently complex, rely on different types of explanatory parameters such as feed rate, depth of cut, cutting speed, tools, and environmental factors. All of these variables significantly influence key response variables like surface quality, tool wear, cutting forces, and energy consumption. The proposed Blockchain-based framework, designed using the Object-Process Methodology (OPM) systems modeling language, enables the reliable exchange of comparative data streams within a unified data analytics platform. By …
Linear Mixed Model For The Surface Roughness Prediction In Hard Turning Operation, Prithbey Raj Dey, David Lee Enke
Linear Mixed Model For The Surface Roughness Prediction In Hard Turning Operation, Prithbey Raj Dey, David Lee Enke
Engineering Management and Systems Engineering Faculty Research & Creative Works
Surface machining using hard turning is an intricate operation due to the influence of multiple machining parameters, their non-linear interactions, and the inherent variability introduced by different experimental trials. This study proposes a Linear Mixed Model (LMM) for predicting surface roughness, effectively addressing the challenges in traditional linear models, posed by the influencing factors, non-linearity, and interactions. The LMM incorporates variability from both fixed effects, such as cutting parameters (feed rate, depth of cut, and cutting speed), and random effects arising from tool wear across experimental runs. As a result, it provides a more comprehensive understanding of how these factors …
The Prospect Of Geospatial Analysis In The Prediction Of Surface Quality In Machining, Prithbey Raj Dey, David Lee Enke
The Prospect Of Geospatial Analysis In The Prediction Of Surface Quality In Machining, Prithbey Raj Dey, David Lee Enke
Engineering Management and Systems Engineering Faculty Research & Creative Works
This research underscores the prospect of geospatial analysis in machining operations to enhance precise prediction and robustness, offering a comprehensive framework of spatial modeling for advanced manufacturing processes. Geospatial analysis not only provides accurate predictions but also estimates the uncertainty associated with these predictions, offering valuable insights for process optimization. The surface quality in the machining processes is expressed by the estimation of the average surface roughness. While machining parameters are extensively analyzed for their influence on surface quality, the roughness profile parameters are inadequately explored. This work integrates these underexplored parameters into geospatial predictive models and evaluates their impact …
A Selective Discontinuous Galerkin Implicit Particle-In-Cell Method For Plasma Simulation With Improved Interpolation, Siyu Wu, Yang Li, Hongtao Liu, Xiaoming He, Yong Cao
A Selective Discontinuous Galerkin Implicit Particle-In-Cell Method For Plasma Simulation With Improved Interpolation, Siyu Wu, Yang Li, Hongtao Liu, Xiaoming He, Yong Cao
Mathematics and Statistics Faculty Research & Creative Works
This article dynamically incorporates multiple ideas into the existing direct implicit particle-in-cell (DIPIC) method for plasma simulation, in order to dramatically improve the DIPIC method for its local mesh refinement needs based on Cartesian meshes as well as its interpolation needs based on the locally refined meshes. One key tool is to utilize the selective discontinuous Galerkin method, which is based on the interior penalty discontinuous Galerkin formulation and the regular local finite element basis functions, as the electric field solver in the DIPIC simulation. This hybrid type finite element method combines the advantages of both continuous and discontinuous finite …
The Nitrogen-Vacancy-Nitrogen Color Center: A Ubiquitous Visible And Near-Infrared-Ii Quantum Emitter In Nitrogen-Doped Diamond, Brett C. Johnson, Mitchell O. De Vries, Alexander J. Healey, Marco Capelli, Anjay Manian, Giannis Thalassinos, Amanda N. Abraham, Harini Hapuarachchi, Tingpeng Luo, Vadym N. Mochalin, Jan Jeske, Jared H. Cole, Salvy Russo
The Nitrogen-Vacancy-Nitrogen Color Center: A Ubiquitous Visible And Near-Infrared-Ii Quantum Emitter In Nitrogen-Doped Diamond, Brett C. Johnson, Mitchell O. De Vries, Alexander J. Healey, Marco Capelli, Anjay Manian, Giannis Thalassinos, Amanda N. Abraham, Harini Hapuarachchi, Tingpeng Luo, Vadym N. Mochalin, Jan Jeske, Jared H. Cole, Salvy Russo
Chemistry Faculty Research & Creative Works
Photoluminescent defects in diamond, such as the nitrogen-vacancy (NV) color center, are at the forefront of emerging optical quantum technologies. Most emit in the visible and near-infrared spectral region below 1000 nm (NIR-I), limiting their applications in photonics, fiber communications, and biology. Here, we show that the nitrogen-vacancy-nitrogen (N2V) center, which emits in the visible and near-infrared-II (NIR-II, 1000-1700 nm), is ubiquitous in as-synthesized and processed nitrogen-doped diamond, ranging from bulk samples to nanoparticles. We demonstrate that N2V is also present in commercially available state-of-the-art NV diamond sensing chips made via chemical vapor deposition (CVD). In high-pressure high-temperature (HPHT) diamonds, …
Reliability Of Cazro3 And Mgo Capacitors At High Temperatures, Alan Devoe, Hung Trinh, Fatih Dogan
Reliability Of Cazro3 And Mgo Capacitors At High Temperatures, Alan Devoe, Hung Trinh, Fatih Dogan
Materials Science and Engineering Faculty Research & Creative Works
Calcium zirconate and magnesium oxide have both been found to have useful dielectric properties at high temperatures. Multilayer ceramic capacitors (MLCCs) were made with these dielectrics and platinum electrodes. The relationship between the lifespan (mean-time to failure) and applied voltage was determined using Weibull statistics. CaZrO3 capacitors were tested between 550◦C and600◦C while MgO capacitors were tested between 600◦C and 650◦C. The temperature coefficient Ea and the voltage coefficient n of the Prokopowicz Vaskas equation were determined under various test conditions. Activation energiesforcalciumzirconateandmagnesiumoxidewere3.25eVand3.48eV, respectively. Resistance degradation of CaZrO3 and MgO capacitors, tested at 600◦Cand250V, were compared.
Effect Of Coarse Aggregate On The Stability And Mechanical Performance Of Ultra-High Performance Concrete (Uhpc), Rui Zhong, Mingyan Pan, Hongyu Wu, Zhao Cheng, Jianzhong Liu, Jingquan Wang, Yiming Yao, Hongyan Ma
Effect Of Coarse Aggregate On The Stability And Mechanical Performance Of Ultra-High Performance Concrete (Uhpc), Rui Zhong, Mingyan Pan, Hongyu Wu, Zhao Cheng, Jianzhong Liu, Jingquan Wang, Yiming Yao, Hongyan Ma
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
The effect of coarse aggregate (CA) on the stability and mechanical performance of ultra-high-performance concrete (UHPC) was investigated. To assess UHPC stability, a unique approach was developed that utilizes specially fabricated large specimens with a depth of 400 mm. It overcomes the drawback of limited CA migration distance using small specimens, which may not replicate conditions relevant to structural applications. The spatial distributions of various constituents along the vertical casting direction were quantified through image processing technology. Results showed an approximately 12 % reduction in CA content in the top layer, while the bottom layer exhibited 12 % more CA …
Predicting Battery Levels Of Sensor Nodes Using Reinforcement Learning In Harsh Underground Mining Environments, Manish Anand Yadav, Mohamed Elmahallawy, Sanjay Madria, Samuel Frimpong
Predicting Battery Levels Of Sensor Nodes Using Reinforcement Learning In Harsh Underground Mining Environments, Manish Anand Yadav, Mohamed Elmahallawy, Sanjay Madria, Samuel Frimpong
Computer Science Faculty Research & Creative Works
Underground mining is a hazardous environment, with frequent accidents leading to significant loss of life each year. To enhance safety, sensor nodes monitor key environmental factors such as temperature, toxic gases, and miners' locations, as well as transmit critical messages. Miners interact with these sensors, which track their movements, enabling their location to be determined even without GPS signals. Therefore, predicting the battery life of these sensors is essential for: (i) rerouting miners during emergencies, (ii) ensuring timely maintenance, and most importantly (iii) identifying sensors that need energy harvesting to maintain vital communication within the mine. In this work, we …
Beyond Boundaries: A Comprehensive Survey Of Transferable Attacks On Ai Systems, Guangjing Wang, Ce Zhou, Yuanda Wang, Bocheng Chen, Hanqing Guo, Qiben Yan
Beyond Boundaries: A Comprehensive Survey Of Transferable Attacks On Ai Systems, Guangjing Wang, Ce Zhou, Yuanda Wang, Bocheng Chen, Hanqing Guo, Qiben Yan
Computer Science Faculty Research & Creative Works
As Artificial Intelligence (AI) systems increasingly underpin critical applications, from autonomous vehicles to biometric authentication, their vulnerability to transferable attacks presents a growing concern. These attacks, designed to generalize across instances, domains, models, tasks, modalities, or even hardware platforms, pose severe risks to security, privacy, and system integrity. This survey delivers the first comprehensive review of transferable attacks across seven major categories, including evasion, backdoor, data poisoning, model stealing, model inversion, membership inference, and side-channel attacks. We introduce a unified six-dimensional taxonomy: cross-instance, cross-domain, cross-modality, cross-model, cross-task, and cross-hardware, which systematically captures the diverse transfer pathways of adversarial strategies. Through …
Extended Tev Halos May Commonly Exist Around Middle-Aged Pulsars, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, C. De León, D. Depaoli, P. Desiati, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, S. Kaufmann, D. Kieda, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martines-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, L. Nellen, M. U. Nisa, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, J. Serna-Franco, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Tores-Escobedo, R. Turner, F. Urena-Mena, E. Varela, L. Villasenor, Xiaojie Wang, E. Wilcox, H. Wu, H. Zhou
Extended Tev Halos May Commonly Exist Around Middle-Aged Pulsars, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, C. De León, D. Depaoli, P. Desiati, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, S. Kaufmann, D. Kieda, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martines-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, L. Nellen, M. U. Nisa, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, J. Serna-Franco, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Tores-Escobedo, R. Turner, F. Urena-Mena, E. Varela, L. Villasenor, Xiaojie Wang, E. Wilcox, H. Wu, H. Zhou
Physics Faculty Research & Creative Works
Extended gamma-ray emission around isolated pulsars at TeV energies, also known as TeV halos, have been found around a handful of middle-aged pulsars. The halos are significantly more extended than their pulsar wind nebulae but much smaller than the particle diffusion length in the interstellar medium. The origin of TeV halos is unknown. Interpretations invoke either local effects related to the environment of a pulsar or generic particle transport behaviors. The latter scenario predicts that TeV halos would be a universal phenomenon for all pulsars. We searched for extended gamma-ray emission around 36 isolated middle-aged pulsars identified by radio and …
Re-Analysis Of The Anthropogenic Effect Of The Covid-19 Global Lockdown On Night-Time Lunar Surface Temperatures, W. Schonberg, S. Haque
Re-Analysis Of The Anthropogenic Effect Of The Covid-19 Global Lockdown On Night-Time Lunar Surface Temperatures, W. Schonberg, S. Haque
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
A study by Durga Prasad and Ambily observed an anomalous decrease in the lunar surface temperatures during the period April–May 2020, which they then attributed to the anthropogenic effects of the COVID-19 global lockdown effect. We have re-examined their data and while the anomalous decrease in the lunar surface temperature during April–May 2020 appears in our analysis as well, so does another significant dip in early 2018. Furthermore, the decline to the minimum observed during April–May 2020 is seen to begin in 2019, that is, quite some time before the COVID-19 event that led to the global lockdown and the …
Performance Evaluation Of Highly Modified Asphalt-Based Binders In High Friction Surface Treatment: Comparative Study With Epoxy-Based System, Alireza Roshan, Magdy Abdelrahman, Mohyeldin Ragab
Performance Evaluation Of Highly Modified Asphalt-Based Binders In High Friction Surface Treatment: Comparative Study With Epoxy-Based System, Alireza Roshan, Magdy Abdelrahman, Mohyeldin Ragab
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
High Friction Surface Treatments (HFSTs) are frequently used to increase skid resistance and reduce collisions, particularly in crash-prone zones, including horizontal curves and intersections. Epoxy-based binders traditionally have been the sole option for HFSTs, but their drawbacks, such as high costs and compatibility challenges, have led to the search for substitute binders, including asphalt-based options. This study investigates the comparative performance of highly modified asphalt-based binders, including polymer-modified, mastic, and highly modified emulsions, in HFST applications using two aggregate types, Calcined Bauxite (CB) and Rhyolite with different gradations, with an emphasis on their frictional properties, durability, and resistance to polishing. …
Cooperative And Bifunctional Ga-Ca-Cr2o3@Cao Structured Monoliths As Versatile Platform For Reactive Capture Of Co2 And Its Subsequent Conversion To Ethylene, Khaled Baamran, Ali A. Rownaghi
Cooperative And Bifunctional Ga-Ca-Cr2o3@Cao Structured Monoliths As Versatile Platform For Reactive Capture Of Co2 And Its Subsequent Conversion To Ethylene, Khaled Baamran, Ali A. Rownaghi
Chemical and Biochemical Engineering Faculty Research & Creative Works
Cooperative and bifunctional materials (BFMs) that integrate adsorbents and catalysts offer a promising strategy for the reactive capture of CO2 to produce valuable fuels and chemicals. In this study, we developed structured BFMs via 3D printing that combine CaO as an adsorbent with Ga–Ca–Cr2O3 metal oxides as the catalyst for the reactive capture of CO2 and its subsequent conversion to C2H4 via the oxidative dehydrogenation of C2H6 (CO2-ODHE). Three different Ga–Ca compositions were used to modify the catalyst surface characteristics and enhance C2H4 selectivity. …
Unraveling The Causal Influences Of Drought And Crop Production On Groundwater Levels Across The Contiguous United States, Nitin K. Singh, Sheila M. Saia, Ruchi Bhattacharya, Hoori Ajami, David M. Borrok
Unraveling The Causal Influences Of Drought And Crop Production On Groundwater Levels Across The Contiguous United States, Nitin K. Singh, Sheila M. Saia, Ruchi Bhattacharya, Hoori Ajami, David M. Borrok
Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works
Groundwater depletion in agricultural-dominated regions is attributed to climate and irrigation withdrawals that support crop production. However, despite decades of effort, knowledge gaps remain in understanding the relative influence of drought and crop production on groundwater levels at the continental scale. Here, utilizing empirical observations, we simultaneously track how long-term trajectories of groundwater levels, crop production of seven crops, and drought have evolved over time, and then integrate these observations with a causality-based attribution framework to unravel the relative impact of drought and crop production on groundwater levels across the contiguous United States (CONUS). We find a dominant pattern of …
Comprehensive Global Data Set Of Uniformly Processed Shear-Wave Splitting Measurements, Jonathan Wolf, Thorsten W. Becker, Edward Garnero, Kelly H. Liu, John D. West
Comprehensive Global Data Set Of Uniformly Processed Shear-Wave Splitting Measurements, Jonathan Wolf, Thorsten W. Becker, Edward Garnero, Kelly H. Liu, John D. West
Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works
Seismic anisotropy can inform us about convective flow in the mantle. Shear waves traveling through azimuthally anisotropic regions split into fast and slow pulses, and measuring the resulting shear-wave splitting provides some of the most direct insights into Earth's interior dynamics. Shear-wave splitting is a constraint for path-averaged azimuthal anisotropy and is often studied regionally. Global compilations of these measurements also exist. Such compilations include measurements obtained using different data processing methodologies (e.g., filtering), which do not necessarily yield identical results, and reproducing a number of studies can be challenging given that not all provide the required information, for example, …
Experimental Study Of Process Parameter Effects On Internal Defects In Titanium Coaxial Wire-Based Laser Metal Deposition, Remy Mathenia, Braden Mclain, Todd Sparks, Frank Liou
Experimental Study Of Process Parameter Effects On Internal Defects In Titanium Coaxial Wire-Based Laser Metal Deposition, Remy Mathenia, Braden Mclain, Todd Sparks, Frank Liou
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Wire-based laser metal deposition is an additive manufacturing process that can be used in the efficient manufacturing of complex structures. This paper utilizes a three-beam coaxial laser wire system to explore the effect of process parameters on the resultant deposition density. The reduction in or elimination of defects is important to the mechanical properties of the additively manufactured material and the widespread adoption of additive manufacturing processes. In this work, two-bead-wide walls were deposited under varying experimental conditions, including the traverse feed rate and workpiece illumination proportion. A method for calculating the bead pitch and layer height increment based on …
Effects Of Processing And Microstructure On The Oxidation Of Zrb2-Sic In Co2, Marharyta Lakusta, Jeremy L. Watts, William G. Fahrenholtz, David W. Lipke
Effects Of Processing And Microstructure On The Oxidation Of Zrb2-Sic In Co2, Marharyta Lakusta, Jeremy L. Watts, William G. Fahrenholtz, David W. Lipke
Materials Science and Engineering Faculty Research & Creative Works
Oxidation kinetics and oxide scale microstructures were compared for ZrB2-30 vol% SiC composites fabricated by hot press sintering of powders and by pressure less sintering of additively manufactured billets. Oxidation in CO2 was conducted at temperatures up to 1400 °C with durations up to 900 h. All specimens exhibited parabolic oxidation kinetics. Materials with similar composition but different processing histories exhibited differences in oxidation behavior that become evident at extended durations (200–900 h) and higher temperatures (1200–1400 °C). Oxidation rates generally increased with grain size, e.g., at 1000 °C for 200 h, oxide scale thickness increased from 36 to …
Intermediate Stage Densification Kinetics Of High-Entropy Ceramics During Spark Plasma Sintering, Steven M. Smith, William G. Fahrenholtz, Greg E. Hilmas, Stefano Curtarolo
Intermediate Stage Densification Kinetics Of High-Entropy Ceramics During Spark Plasma Sintering, Steven M. Smith, William G. Fahrenholtz, Greg E. Hilmas, Stefano Curtarolo
Materials Science and Engineering Faculty Research & Creative Works
The intermediate stage densification kinetics of (Hf, Nb, Ta, Ti, Zr) B2 and (Hf, Nb, Ta, Ti, Zr) C were studied using a Coble creep rate model. (Hf, Nb, Ta, Ti, Zr) B2 was synthesized by boro/carbothermal reduction and (Hf, Nb, Ta, Ti, Zr) C was synthesized by carbothermal reduction. Both ceramics were densified by spark plasma sintering at 1700–1850°C. The activation energies for densification were 575 ± 53 kJ/mol for the high-entropy boride and 646 ± 4 kJ/mol for the high-entropy carbide. The densification mechanisms were grain boundary diffusion for the high-entropy boride and lattice diffusion for the high-entropy …
Interfacial Defect Properties Of High-Entropy Carbides: Stacking Faults, Shockley Partial Dislocations, And A New Evans-Polanyi-Semenov Relation, Samuel E. Daigle, Stefano Curtarolo, William G. Fahrenholtz, Jon Paul Maria, Douglas E. Wolfe, Eva Zurek, Donald W. Brenner
Interfacial Defect Properties Of High-Entropy Carbides: Stacking Faults, Shockley Partial Dislocations, And A New Evans-Polanyi-Semenov Relation, Samuel E. Daigle, Stefano Curtarolo, William G. Fahrenholtz, Jon Paul Maria, Douglas E. Wolfe, Eva Zurek, Donald W. Brenner
Materials Science and Engineering Faculty Research & Creative Works
Using first principles calculations, {111} intrinsic stacking fault (ISF) energies in groups IVB, VB, and VIB high-entropy transition metal carbides (HETMCs) are shown to be predictable from an optimized rule of mixtures based on the atomic arrangement near the stacking fault. A composition-independent linear relationship is demonstrated between the ISF energies and the unstable stacking fault (USF) energies along the (112¯){111} γsurface slip path. This relationship represents a new application of the Evans-Polanyi-Semenov principle by treating the ISF and USF energies as analogous to the heat of reaction and transition state barrier in chemical reactions. Further, a full defect energy …
Tumor-Specific Surface Marker–Independent Targeting Of Tumors Through Nanotechnology And Bioorthogonal Glycochemistry, Hyesun Hyun, Bo Sun, Mostafa Yazdimamaghani, Albert Wielgus, Yue Wang, Stephanie Ann Montgomery, Tian Zhang, Jianjun Cheng, Jonathan S. Serody, Andrew Z. Wang
Tumor-Specific Surface Marker–Independent Targeting Of Tumors Through Nanotechnology And Bioorthogonal Glycochemistry, Hyesun Hyun, Bo Sun, Mostafa Yazdimamaghani, Albert Wielgus, Yue Wang, Stephanie Ann Montgomery, Tian Zhang, Jianjun Cheng, Jonathan S. Serody, Andrew Z. Wang
Chemical and Biochemical Engineering Faculty Research & Creative Works
Biological targeting is crucial for effective cancer treatment with reduced toxicity but is limited by the availability of tumor surface markers. To overcome this, we developed a nanoparticle-based (NP-based), tumor-specific surface marker–independent (TRACER) targeting approach. Utilizing the unique biodistribution properties of NPs, we encapsulated Ac4ManNAz (Maz) to selectively label tumors with azide-reactive groups. Surprisingly, while NP-delivered Maz was cleared by the liver, it did not label macrophages, potentially reducing off-target effects. To exploit this tumor-specific labeling, we functionalized anti–4-1BB Abs with dibenzo cyclooctyne to target azide-labeled tumor cells and activate the immune response. In syngeneic B16F10 melanoma and orthotopic 4T1 …
May 2025 Cafe Newsletter, Center For Advancing Faculty Excellence
May 2025 Cafe Newsletter, Center For Advancing Faculty Excellence
CAFE Faculty Newsletters
No abstract provided.
Picosecond Laser Ranging At 1.5 Μm Using Dispersive Interferometry, Behzad Boroomandisorkhabi, Xiangrui Su, Mina Esmaeelpour
Picosecond Laser Ranging At 1.5 Μm Using Dispersive Interferometry, Behzad Boroomandisorkhabi, Xiangrui Su, Mina Esmaeelpour
Electrical and Computer Engineering Faculty Research & Creative Works
Precise displacement measurement is essential for engineering, industrial, and scientific purposes. Ultrafast laser techniques are preferred for real-time applications due to their single-shot measurement capability and high resolution. To create a high-performance and cost-effective system with less complexity, capable of achieving real-time measurement with high micrometer spatial resolution, we have used a picosecond pulsed laser at the telecommunication wavelength of 1.5 μm in combination with dispersive interferometry. The instantaneous frequency measurement took place using the time-stretch technique incorporating dispersion compensating fiber induced chirp. Results using a 7-picosecond laser at 1.5 μm with a 10 MHz repetition rate are presented. Frequency …
Fact-Based Counter Narrative Generation To Combat Hate Speech, Brian Wilk, Homaira Huda Shomee, Suman Kalyan Maity, Sourav Medya
Fact-Based Counter Narrative Generation To Combat Hate Speech, Brian Wilk, Homaira Huda Shomee, Suman Kalyan Maity, Sourav Medya
Computer Science Faculty Research & Creative Works
Online hatred has become an increasingly pervasive issue, affecting individuals and communities across various digital platforms. To combat hate speech in such platforms, counter narratives (CNs) are regarded as an effective method. In recent years, there has been growing interest in using generative AI tools to construct CNs. However, most of the generative models produce generic responses to hate speech and can hallucinate, reducing their effectiveness. To address the above limitations, we propose a counter narrative generation method that enhances CNs by providing non-aggressive, fact-based narratives with relevant background knowledge from two distinct sources, including a web search module. Furthermore, …
Polymetal Phosphate Cement From Tin Fuming Furnace Slag: Hydration Mechanism, Mechanical Performance, And Environmental Safety, Peiwen Lv, Xintao Zhou, Zhongqiu Luo, Cuirong Yan, Xiunan Cai, Ting Huang, Pingyan Wang, Hongyan Ma
Polymetal Phosphate Cement From Tin Fuming Furnace Slag: Hydration Mechanism, Mechanical Performance, And Environmental Safety, Peiwen Lv, Xintao Zhou, Zhongqiu Luo, Cuirong Yan, Xiunan Cai, Ting Huang, Pingyan Wang, Hongyan Ma
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Phosphate cement materials are ideal binders for the rapid repairment of civil engineering and solidification/stabilization of hazardous solid wastes due to their fast setting, high early strength and strong adhesion. However, the use of pure metal oxides as the raw base materials and their deactive pretreatment result in the high cost and energy consumption, limiting its broad applications. In this study, an eco-friendly polymetal phosphate cement (PMPC) was developed using tin fuming furnace slag (TFFS) as the primary base material. The hydration behavior, microstructure, mechanical properties, and environmental safety of PMPC were comprehensively evaluated. The results showed that the hydration …
2025 Scholarly Productivity Report, Missouri University Of Science And Technology
2025 Scholarly Productivity Report, Missouri University Of Science And Technology
Civil, Architectural and Environmental Engineering Scholarly Productivity Reports
No abstract provided.
Compositionally Complex Diborides: Competing Solubility During Sintering And Properties, Laura Silvestroni, Carlo Baldisserri, Jacopo Matteo Tabaglio, Nicola Gilli, Jeremy Watts, Steven M.I. Smith, Gregory E. Hilmas, William G. Fahrenholtz
Compositionally Complex Diborides: Competing Solubility During Sintering And Properties, Laura Silvestroni, Carlo Baldisserri, Jacopo Matteo Tabaglio, Nicola Gilli, Jeremy Watts, Steven M.I. Smith, Gregory E. Hilmas, William G. Fahrenholtz
Materials Science and Engineering Faculty Research & Creative Works
An ultra-high temperature ceramic based on ZrB2, TiB2, and SiC was hot pressed to full density at 1850 °C. Addition of 5 vol% of different metal-compounds, in the form of HfC, VC, NbC or CrB2, increased the densification temperature to 1910 °C. The resulting compositionally complex ceramics had homogeneous microstructures with boride grains exhibiting core-shell features. The shell was a solid solution containing variable amounts of the three metals. Notably, TiB2 remained as a discrete phase in the reference material and in the presence of the V- and Cr- based additions, whilst it dissolved into the main ZrB2-based grains for …
Ute Mri For Assessing Demyelination In An Mtbi Mouse Model: An Open-Field Low-Intensity Blast Study, Yajun Ma, Qingbo Tang, Xin Cheng, Jiyo S. Athertya, David Coughlin, Eric Y. Chang, Catherine E. Johnson, Jiankun Cui, Zezong Gu, Jiang Du
Ute Mri For Assessing Demyelination In An Mtbi Mouse Model: An Open-Field Low-Intensity Blast Study, Yajun Ma, Qingbo Tang, Xin Cheng, Jiyo S. Athertya, David Coughlin, Eric Y. Chang, Catherine E. Johnson, Jiankun Cui, Zezong Gu, Jiang Du
Mining Engineering Faculty Research & Creative Works
Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to assess demyelination in mice with mTBI induced by open-field low-intensity blast (LIB) using a novel three-dimensional short repetition time adiabatic inversion recovery UTE (3D STAIR-UTE) magnetic resonance imaging (MRI) sequence. Thirty male C57BL/6 mice, with 15 experiencing mTBI and 15 serving as sham controls, were included in this study. Behavioral tests were performed starting at 5 days post-injury to assess motor activity and anxiety-like responses followed by STAIR-UTE …
Numerical Simulation Of Heat Transfer In Self-Propagating High-Temperature Synthesis (Shs)-Based Calcination Of Limestone, Sayee Srikarah Volaity, Shubham Agrawal, Srinivas Kilambi, Patrick Phelan, Aditya Kumar, Narayanan Neithalath
Numerical Simulation Of Heat Transfer In Self-Propagating High-Temperature Synthesis (Shs)-Based Calcination Of Limestone, Sayee Srikarah Volaity, Shubham Agrawal, Srinivas Kilambi, Patrick Phelan, Aditya Kumar, Narayanan Neithalath
Materials Science and Engineering Faculty Research & Creative Works
Calcination of limestone, a high temperature (∼900 °C) process that emits 44 % of the mass of limestone as CO2, is a critical process in the production of many industrially important materials. To soften the CO2-related impacts of traditional calcination, and to enable ultrafast synthesis of lime, a novel approach based on self-propagating high-temperature synthesis (SHS) has been put forward. SHS uses exothermic heat released by the combustion of fuel intermixed with the reactants to advance the reaction, and hence requires the provision of lower external temperatures. This study introduces a microstructure-guided modeling approach to understand …
Modular Molecular Design Of Polymerized Pro-Estrogen Materials Enables Controlled Astrocyte Response, Devan L. Puhl, Alexis Ziemba, Samuel A.T. Ellman, Alex Hsu, Jayant Saksena, Penelope Phillips Falcone, Bailey Balouch, Deniz Rende, Tanner Fink, R. Helen Zha, Ryan J. Gilbert, Edmund F. Palermo
Modular Molecular Design Of Polymerized Pro-Estrogen Materials Enables Controlled Astrocyte Response, Devan L. Puhl, Alexis Ziemba, Samuel A.T. Ellman, Alex Hsu, Jayant Saksena, Penelope Phillips Falcone, Bailey Balouch, Deniz Rende, Tanner Fink, R. Helen Zha, Ryan J. Gilbert, Edmund F. Palermo
Chemical and Biochemical Engineering Faculty Research & Creative Works
The hormone 17β-estradiol (estrogen or "E2") has demonstrated robust neuroprotective properties in countering oxidative stress-induced neurotoxicity, as well as strong neurotrophic properties to promote axonal growth, following injury to the central nervous system (CNS). However, oral or injected E2 is a suboptimal drug, as systemic administration fails to achieve a therapeutic dose at the injury site, in addition to being contraindicated in most male patients. Polymerized pro-drug biomaterials can mitigate these issues by locally releasing small quantities of drug over vastly extended timescales. We sought to study the effect of the biomaterial properties of poly(pro-E2) on astrocyte-surface interactions because astrocytes …