Digital Commons Network^™

Tumor-Specific Surface Marker–Independent Targeting Of Tumors Through Nanotechnology And Bioorthogonal Glycochemistry, Hyesun Hyun, Bo Sun, Mostafa Yazdimamaghani, Albert Wielgus, Yue Wang, Stephanie Ann Montgomery, Tian Zhang, Jianjun Cheng, Jonathan S. Serody, Andrew Z. Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Biological targeting is crucial for effective cancer treatment with reduced toxicity but is limited by the availability of tumor surface markers. To overcome this, we developed a nanoparticle-based (NP-based), tumor-specific surface marker–independent (TRACER) targeting approach. Utilizing the unique biodistribution properties of NPs, we encapsulated Ac4ManNAz (Maz) to selectively label tumors with azide-reactive groups. Surprisingly, while NP-delivered Maz was cleared by the liver, it did not label macrophages, potentially reducing off-target effects. To exploit this tumor-specific labeling, we functionalized anti–4-1BB Abs with dibenzo cyclooctyne to target azide-labeled tumor cells and activate the immune response. In syngeneic B16F10 melanoma and orthotopic 4T1 …

Picosecond Laser Ranging At 1.5 Μm Using Dispersive Interferometry, Behzad Boroomandisorkhabi, Xiangrui Su, Mina Esmaeelpour

Electrical and Computer Engineering Faculty Research & Creative Works

Precise displacement measurement is essential for engineering, industrial, and scientific purposes. Ultrafast laser techniques are preferred for real-time applications due to their single-shot measurement capability and high resolution. To create a high-performance and cost-effective system with less complexity, capable of achieving real-time measurement with high micrometer spatial resolution, we have used a picosecond pulsed laser at the telecommunication wavelength of 1.5 μm in combination with dispersive interferometry. The instantaneous frequency measurement took place using the time-stretch technique incorporating dispersion compensating fiber induced chirp. Results using a 7-picosecond laser at 1.5 μm with a 10 MHz repetition rate are presented. Frequency …

Unraveling The Causal Influences Of Drought And Crop Production On Groundwater Levels Across The Contiguous United States, Nitin K. Singh, Sheila M. Saia, Ruchi Bhattacharya, Hoori Ajami, David M. Borrok

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Groundwater depletion in agricultural-dominated regions is attributed to climate and irrigation withdrawals that support crop production. However, despite decades of effort, knowledge gaps remain in understanding the relative influence of drought and crop production on groundwater levels at the continental scale. Here, utilizing empirical observations, we simultaneously track how long-term trajectories of groundwater levels, crop production of seven crops, and drought have evolved over time, and then integrate these observations with a causality-based attribution framework to unravel the relative impact of drought and crop production on groundwater levels across the contiguous United States (CONUS). We find a dominant pattern of …

Comprehensive Global Data Set Of Uniformly Processed Shear-Wave Splitting Measurements, Jonathan Wolf, Thorsten W. Becker, Edward Garnero, Kelly H. Liu, John D. West

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Seismic anisotropy can inform us about convective flow in the mantle. Shear waves traveling through azimuthally anisotropic regions split into fast and slow pulses, and measuring the resulting shear-wave splitting provides some of the most direct insights into Earth's interior dynamics. Shear-wave splitting is a constraint for path-averaged azimuthal anisotropy and is often studied regionally. Global compilations of these measurements also exist. Such compilations include measurements obtained using different data processing methodologies (e.g., filtering), which do not necessarily yield identical results, and reproducing a number of studies can be challenging given that not all provide the required information, for example, …

A Pure Rotational Spectroscopic Study Of Two Nearly-Equivalent Structures Of Hexafluoroacetone Imine, (Cf3)C=Nh, Daniel A. Obenchain, Beppo Hartwig, Daniel J. Frohman, Garry S. Grubbs, B. E. Long, Wallace C. Pringle, Stewart E. Novick, S. A. Cooke

Chemistry Faculty Research & Creative Works

Rotational spectra for hexafluoroacetone imine, the singly substituted 13C isotopologues, and the 15N isotopologue, have been recorded using both cavity and chirped pulse Fourier transform microwave spectrometers. The spectra observed present as being doubled with separations between each pair of transitions being on the order of a few tens of kilohertz which is consistent with a large amplitude motion producing two torsional substates. The observed splitting is most likely due to the combined motions of the CF₃ groups, for which the calculated barrier is small. However, no transitions between states could be observed and, similarly, no Coriolis coupling parameters …

Reflections On Linear B, (Part 11): Linear B Sign 55 And The Ancient Egyptian Wish For An Eternity Of Life Or Rule, Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

Linear B sign 55 (pronounced /nu/) is evidently of unknown origin, and the present article suggests a possible solution. As with several other Linear B signs I have treated, the solution is sought in Egyptian hieroglyphs, only this time two hieroglyphs are required for the solution (one for the shape, one for the pronunciation).

The shape of the Linear B sign is explainable as a simplified and somewhat altered form of a similarly shaped Egyptian hieroglyph which was pronounced /ḥeḥ/ and meant ‘a great but indefinite number;’ then by extension: ‘eternity’ and from there to Ḥeḥ, a god symbolizing eternity. …

Fact-Based Counter Narrative Generation To Combat Hate Speech, Brian Wilk, Homaira Huda Shomee, Suman Kalyan Maity, Sourav Medya

Computer Science Faculty Research & Creative Works

Online hatred has become an increasingly pervasive issue, affecting individuals and communities across various digital platforms. To combat hate speech in such platforms, counter narratives (CNs) are regarded as an effective method. In recent years, there has been growing interest in using generative AI tools to construct CNs. However, most of the generative models produce generic responses to hate speech and can hallucinate, reducing their effectiveness. To address the above limitations, we propose a counter narrative generation method that enhances CNs by providing non-aggressive, fact-based narratives with relevant background knowledge from two distinct sources, including a web search module. Furthermore, …

Stability, Binding, And Charge Localization In Amorphous Tin Monoxide: A-Sno And A-Sn-Ta-O With Variable Composition, Julia E. Medvedeva, Joshua Santy, Mathew Pollard

Physics Faculty Research & Creative Works

The structural, electronic, and optical properties of amorphous SnO and Sn-Ta-O (with Sn:Ta ratios 5:1, 3:2, and 1:2) are investigated as a function of density and metal composition using ab initio molecular dynamics simulations and hybrid functional calculations. The short- and medium-range structures of amorphous oxides are thoroughly studied by calculating the effective coordination numbers, effective distances, distortion, and their time variances for metal-oxygen (M-O), O-M, M-M shells, the M-O-M and O-M-O angle distribution, as well as the volume, shape, and distribution of structural voids. Disorder is found to suppress both Sn-O and Sn-Sn coordination but not the O-Sn coordination. …

Polymetal Phosphate Cement From Tin Fuming Furnace Slag: Hydration Mechanism, Mechanical Performance, And Environmental Safety, Peiwen Lv, Xintao Zhou, Zhongqiu Luo, Cuirong Yan, Xiunan Cai, Ting Huang, Pingyan Wang, Hongyan Ma

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Phosphate cement materials are ideal binders for the rapid repairment of civil engineering and solidification/stabilization of hazardous solid wastes due to their fast setting, high early strength and strong adhesion. However, the use of pure metal oxides as the raw base materials and their deactive pretreatment result in the high cost and energy consumption, limiting its broad applications. In this study, an eco-friendly polymetal phosphate cement (PMPC) was developed using tin fuming furnace slag (TFFS) as the primary base material. The hydration behavior, microstructure, mechanical properties, and environmental safety of PMPC were comprehensively evaluated. The results showed that the hydration …

2025 Scholarly Productivity Report, Missouri University Of Science And Technology

Civil, Architectural and Environmental Engineering Scholarly Productivity Reports

No abstract provided.

Compositionally Complex Diborides: Competing Solubility During Sintering And Properties, Laura Silvestroni, Carlo Baldisserri, Jacopo Matteo Tabaglio, Nicola Gilli, Jeremy Watts, Steven M.I. Smith, Gregory E. Hilmas, William G. Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

An ultra-high temperature ceramic based on ZrB2, TiB2, and SiC was hot pressed to full density at 1850 °C. Addition of 5 vol% of different metal-compounds, in the form of HfC, VC, NbC or CrB2, increased the densification temperature to 1910 °C. The resulting compositionally complex ceramics had homogeneous microstructures with boride grains exhibiting core-shell features. The shell was a solid solution containing variable amounts of the three metals. Notably, TiB2 remained as a discrete phase in the reference material and in the presence of the V- and Cr- based additions, whilst it dissolved into the main ZrB2-based grains for …

Modular Molecular Design Of Polymerized Pro-Estrogen Materials Enables Controlled Astrocyte Response, Devan L. Puhl, Alexis Ziemba, Samuel A.T. Ellman, Alex Hsu, Jayant Saksena, Penelope Phillips Falcone, Bailey Balouch, Deniz Rende, Tanner Fink, R. Helen Zha, Ryan J. Gilbert, Edmund F. Palermo

Chemical and Biochemical Engineering Faculty Research & Creative Works

The hormone 17β-estradiol (estrogen or "E2") has demonstrated robust neuroprotective properties in countering oxidative stress-induced neurotoxicity, as well as strong neurotrophic properties to promote axonal growth, following injury to the central nervous system (CNS). However, oral or injected E2 is a suboptimal drug, as systemic administration fails to achieve a therapeutic dose at the injury site, in addition to being contraindicated in most male patients. Polymerized pro-drug biomaterials can mitigate these issues by locally releasing small quantities of drug over vastly extended timescales. We sought to study the effect of the biomaterial properties of poly(pro-E2) on astrocyte-surface interactions because astrocytes …

Ute Mri For Assessing Demyelination In An Mtbi Mouse Model: An Open-Field Low-Intensity Blast Study, Yajun Ma, Qingbo Tang, Xin Cheng, Jiyo S. Athertya, David Coughlin, Eric Y. Chang, Catherine E. Johnson, Jiankun Cui, Zezong Gu, Jiang Du

Mining Engineering Faculty Research & Creative Works

Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to assess demyelination in mice with mTBI induced by open-field low-intensity blast (LIB) using a novel three-dimensional short repetition time adiabatic inversion recovery UTE (3D STAIR-UTE) magnetic resonance imaging (MRI) sequence. Thirty male C57BL/6 mice, with 15 experiencing mTBI and 15 serving as sham controls, were included in this study. Behavioral tests were performed starting at 5 days post-injury to assess motor activity and anxiety-like responses followed by STAIR-UTE …

Numerical Simulation Of Heat Transfer In Self-Propagating High-Temperature Synthesis (Shs)-Based Calcination Of Limestone, Sayee Srikarah Volaity, Shubham Agrawal, Srinivas Kilambi, Patrick Phelan, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Calcination of limestone, a high temperature (∼900 °C) process that emits 44 % of the mass of limestone as CO₂, is a critical process in the production of many industrially important materials. To soften the CO₂-related impacts of traditional calcination, and to enable ultrafast synthesis of lime, a novel approach based on self-propagating high-temperature synthesis (SHS) has been put forward. SHS uses exothermic heat released by the combustion of fuel intermixed with the reactants to advance the reaction, and hence requires the provision of lower external temperatures. This study introduces a microstructure-guided modeling approach to understand …

Ultrahigh Electric Charge Density Harvested From Pre-Compressed Ferroelectric Ceramics, Sergey I. Shkuratov, Jason Baird, Alexander S. Shkuratov, Christopher S. Lynch

Mining Engineering Faculty Research & Creative Works

Ferroelectric elements of high-power electrical generators, utilizing the ability of ferroelectric materials to produce electric charge under mechanical stress, are subjected to either high-pressure shock or moderate-pressure impact loading. The results are reported herein on experimental investigations of a different mode for the generation of a high electric charge density, one that utilizes pre-compressed ferroelectric ceramics. Hard PZT 52/48 (Navy Type I/PZT-4) ferroelectric ceramic specimens were subjected to static uniaxial compressive stress parallel to polarization. At the moment of operation, the output terminals of the specimens were connected to an external circuit, and the applied stress was quickly removed, resulting …

Systematic Characterization Of The Homogeneous And Heterogeneous Hydrogen Halide Dimers, Yuan Xue, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

This study systematically characterizes the four homogeneous and six heterogeneous hydrogen-bonded dimers formed by hydrogen halide pairs (HX/HY where X, Y = F, Cl, Br, and I). The notation HX⋯HY indicates the direction of the hydrogen bond from the HY donor to the HX acceptor. All stationary points reported for these ten dimer systems are fully optimized utilizing the MP2 and CCSD(T) ab initio methods in conjunction with quadruple-ζ correlation-consistent basis sets augmented with diffuse functions, and their nature is verified by harmonic vibrational frequency computations. The electronic dissociation energies (De) for all ten global minima are evaluated near the …

Detection Of Co2 Locally Generated By Formate Dehydrogenase Using Carbonate Ion-Selective Micropipette Electrodes, Seol Baek, Salvador Gutierrez-Portocarrero, Rokas Gerulskis, Shelley D. Minteer, Sean R. German, Henry S. White

Chemistry Faculty Research & Creative Works

Many technologies involve immobilizing catalysts such as enzymes on surfaces, and the catalytic activities or functional efficiencies of these surface-bound catalysts can vary depending on orientations, localized binding sites, active sites, and intrinsic molecular nature. Accurate and rapid quantification of reaction products from surface-immobilized catalysts is crucial for understanding the selectivity, mechanisms, and reaction dynamics of catalytic systems and for revealing heterogeneous catalytic activities and reaction sites for applications such as biosensors and energy conversion/generation systems. Here, we demonstrate the feasibility of localized enzymatic activity measurements using microscale carbon dioxide (CO₂)-sensitive ion-selective electrode (ISE) pipettes (0.5-2.5 μm tip …

Fabrication Of Ultra High-Temperature Compact Heat Exchanger By Extrusion-Based Ceramic Additive Manufacturing, Abid Hasan Rafi, David W. Lipke, Jeremy Lee Watts, Greg Hilmas, Ming-Chuan Leu

Miners Solving for Tomorrow Research Conference

No abstract provided.

Effects Of The Sintering Process On Additively Manufactured Copper Projectiles, Avery Lyons, William Petzoldt, Phillip R. Mulligan

Miners Solving for Tomorrow Research Conference

No abstract provided.

Cascaded Hydropower Plant Optimization Using A Bi-Level Mixed Integer Model, Ahmad Heidari, Rui Bo

Miners Solving for Tomorrow Research Conference

No abstract provided.

Multidisciplinary Design Optimization Of A Notional Cubesat Mission, Collin Gentry

Miners Solving for Tomorrow Research Conference

No abstract provided.

Transition Metal Nanocomposites: Nonenzymatic Biosensor For Neurochemical Detection, Amitav Sen, Ace Cannon, Manashi Nath

Miners Solving for Tomorrow Research Conference

No abstract provided.

Robust Multifidelity Operator Learning For Partial Differential Equations, Jacob Hauck, Yanzhi Zhang

Miners Solving for Tomorrow Research Conference

No abstract provided.

Development Of Intelligent Robot Assistance In Mining (Iram), Khosro Ghorbani Zadeh, Yun Seong Song

Miners Solving for Tomorrow Research Conference

No abstract provided.

Additive Manufacturing Of Thermoplastic Composites, Matik Heskin, K. Chandrashekhara, Richard Billo, Ming-Chuan Leu, Thomas P. Schuman

Miners Solving for Tomorrow Research Conference

No abstract provided.

Neural Network-Based Renewal Reward Theory (Rrt) For Optimal Maintenance Scheduling, Samiksha Aryal, Abhijit Gosavi, Susan L. Murray

Miners Solving for Tomorrow Research Conference

No abstract provided.

Physical Characterization Of Copper Anode Slimes, Carter Glynn, Michael S. Moats

Miners Solving for Tomorrow Research Conference

No abstract provided.

Extreme Fast Charging Algorithm For Lithium-Ion Batteries With Precision Lithium Plating Regulation For Degradation Reduction, Kiernan O'Boyle, Yaqi Zhu, Jonghyun Park

Miners Solving for Tomorrow Research Conference

No abstract provided.

Sustainable Solutions To Eutrophication: The Role Of Glass Fertilizers, Lucas Greiner, Charmayne Lonergan

Miners Solving for Tomorrow Research Conference

No abstract provided.

Electrospun Rgo-Pan Filters For High-Performance Removal Of Respirable Silica And Coal Dust, Mahsa Moradi, Ashish Kakoria, Guang Xu

Miners Solving for Tomorrow Research Conference

No abstract provided.