Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Marquette University

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 31 - 58 of 58

Full-Text Articles in Entire DC Network

All Sites But Skin Cancer Incidences Analyzed Worldwide By Sex, Age, And Skin Type Over Time (1955-2007), Advancing Age, And Uvb Dose Reveals Important Carcinogenic Drivers, Dianne E. Godar, Rossen Gurov, Stephen Merrill Jan 2017

All Sites But Skin Cancer Incidences Analyzed Worldwide By Sex, Age, And Skin Type Over Time (1955-2007), Advancing Age, And Uvb Dose Reveals Important Carcinogenic Drivers, Dianne E. Godar, Rossen Gurov, Stephen Merrill

Mathematics, Statistics and Computer Science Faculty Research and Publications

Because we observed increasing incidences over time, advancing age, higher estrogen levels, decreasing UVB (290-315 nm) doses, or lower vitamin D3, and Human Papillomavirus hiding in immune-privileged sites of hair follicles play roles in melanoma, we wondered if the majority of cancers might have similar carcinogenic drivers. To investigate this possibility, we performed worldwide analysis of all sites but skin cancer over time (1955-2007), advancing age, and UVB doses for males and females with all skin types and ages (0-85+) and in five age groups using IARC data. To investigate Human Papillomavirus’s role, we analyzed the incidences of …

Go to article

Optimization Of The Bowtie Gap Geometry For A Maximum Electric Field Enhancement, Tsenguun Byambadorj Oct 2016

Optimization Of The Bowtie Gap Geometry For A Maximum Electric Field Enhancement, Tsenguun Byambadorj

Master's Theses (2009 -)

Optimization of the geometry of a metallic bowtie gap at radio frequency is presented in this thesis. Since the design and fabrication of a plasmonic device (nanogap) at nanoscale is challenging, the results of this study can be used to estimate the best design parameters for nanogap structure. The geometry of the bowtie gap including gap size, tip width, metal thickness, and tip angle are investigated at macroscale to find the maximum electric field enhancement across the gap. This thesis focuses on the simulation portion of a work that consists of experimental and simulation platforms. The simulation platform is created …

Go to article

Another Generalized Transmuted Family Of Distributions: Properties And Applications, Faton Merovci, Morad Alizadeh, Gholamhossein Hamedani Sep 2016

Another Generalized Transmuted Family Of Distributions: Properties And Applications, Faton Merovci, Morad Alizadeh, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

We introduce and study general mathematical properties of a new generator of continuous distributions with two extra parameters called the Another generalized transmuted family of distributions. We present some special models. We investigate the asymptotes and shapes. The new density function can be expressed as a linear combination of exponentiated densities based on the same baseline distribution. We obtain explicit expressions for the ordinary and incomplete moments and generating functions, Bonferroni and Lorenz curves, asymptotic distribution of the extreme values, Shannon and Renyi entropies and order statistics, which hold for any baseline model, certain characterisations are presented. Further, we …

Go to article

Gene Set Enrichment And Projection: A Computational Tool For Knowledge Discovery In Transcriptomes, Karl Douglas Stamm Jul 2016

Gene Set Enrichment And Projection: A Computational Tool For Knowledge Discovery In Transcriptomes, Karl Douglas Stamm

Dissertations (1934 -)

Explaining the mechanism behind a genetic disease involves two phases, collecting and analyzing data associated to the disease, then interpreting those data in the context of biological systems. The objective of this dissertation was to develop a method of integrating complementary datasets surrounding any single biological process, with the goal of presenting the response to a signal in terms of a set of downstream biological effects. This dissertation specifically tests the hypothesis that computational projection methods overlaid with domain expertise can direct research towards relevant systems-level signals underlying complex genetic disease. To this end, I developed a software algorithm named …

Go to article

Photochemical Electrocyclic Ring Closure And Elimination Reactions Of N-(Oxothioxanthenyl)Naphthothiophene Carboxamides, Himali Devika Jayasekara Apr 2016

Photochemical Electrocyclic Ring Closure And Elimination Reactions Of N-(Oxothioxanthenyl)Naphthothiophene Carboxamides, Himali Devika Jayasekara

Dissertations (1934 -)

Photochemical cleavage reactions have found a widespread used in biological applications that require the photorelease of biologically active molecules such as proteins, peptides, neurotransmitters, and nucleotide phosphates. This research focuses on the design of photoremovable protecting groups which can be utilized to release these biomolecules by photolysis. These biomolecules are attached to the photoremovable protecting group at the sites of functional groups that are present within these substrates. Such functional groups are carboxylates, phosphates, thiolates, or phenolates, which upon exposure to light, are released as anions of varying basicities. The photochemical reaction involved is an electrocyclic ring closure between aromatic …

Go to article

Impact Of Sleep And Circadian Disruption On Energy Balance And Diabetes: A Summary Of Workshop Discussions, Deanna M. Arble, Joseph Bass, Cecilia Diniz Behn, Matthew P. Butler, Etienne Challet, Charles Czeisler, Christopher M. Depner, Joel Elmquist, Paul Franken, Michael A. Grandner, Erin C. Hanlon, Alex C. Keene, Michael J. Joyner, Ilia Karatsoreos, Philip A. Kern, Samuel Klein, Christopher J. Morris, Allan I. Pack, Satchidananda Panda, Louis J. Ptacek, Naresh M. Punjabi, Paolo Sessone-Corsi, Frank A. Scheer, Richa Saxena, Elizabeth R. Seaquest, Matthew S. Thimgan, Eve Van Cauter, Kenneth P. Wright Dec 2015

Impact Of Sleep And Circadian Disruption On Energy Balance And Diabetes: A Summary Of Workshop Discussions, Deanna M. Arble, Joseph Bass, Cecilia Diniz Behn, Matthew P. Butler, Etienne Challet, Charles Czeisler, Christopher M. Depner, Joel Elmquist, Paul Franken, Michael A. Grandner, Erin C. Hanlon, Alex C. Keene, Michael J. Joyner, Ilia Karatsoreos, Philip A. Kern, Samuel Klein, Christopher J. Morris, Allan I. Pack, Satchidananda Panda, Louis J. Ptacek, Naresh M. Punjabi, Paolo Sessone-Corsi, Frank A. Scheer, Richa Saxena, Elizabeth R. Seaquest, Matthew S. Thimgan, Eve Van Cauter, Kenneth P. Wright

Biological Sciences Faculty Research and Publications

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact …

Go to article

Acetyl Coa Carboxylase Inactivation And Meiotic Maturation In Mouse Oocytes, Deepa S. Valsangkar, Stephen M. Downs Sep 2015

Acetyl Coa Carboxylase Inactivation And Meiotic Maturation In Mouse Oocytes, Deepa S. Valsangkar, Stephen M. Downs

Biological Sciences Faculty Research and Publications

In mouse oocytes, meiotic induction by pharmacological activation of PRKA (adenosine monophosphate-activated protein kinase; formerly known as AMPK) or by hormones depends on stimulation of fatty acid oxidation (FAO). PRKA stimulates FAO by phosphorylating and inactivating acetyl CoA carboxylase (ACAC; formerly ACC), leading to decreased malonyl CoA levels and augmenting fatty-acid transport into mitochondria. We investigated a role for ACAC inactivation in meiotic resumption by testing the effect of two ACAC inhibitors, CP-640186 and Soraphen A, on mouse oocytes maintained in meiotic arrest in vitro. These inhibitors significantly stimulated the resumption of meiosis in arrested cumulus cell-enclosed oocytes, denuded oocytes, …

Go to article

The Transmuted Exponentiated Generalized-G Family Of Distributions, Haitham M. Yousof, Ahmed Z. Afify, Morad Alizadeh, Nadeem Shafique Butt, Gholamhossein Hamedani Jan 2015

The Transmuted Exponentiated Generalized-G Family Of Distributions, Haitham M. Yousof, Ahmed Z. Afify, Morad Alizadeh, Nadeem Shafique Butt, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

We introduce a new class of continuous distributions called the transmuted exponentiated generalized-G family which extends the exponentiated generalized-G class introduced by Cordeiro et al. (2013). We provide some special models for the new family. Some of its mathematical properties including explicit expressions for the ordinary and incomplete moments, generating function, Rényi and Shannon entropies, order statistics and probability weighted moments are derived. The estimation of the model parameters is performed by maximum likelihood. The flexibility of the proposed family is illustrated by means of an applications to real dataset.

Go to article

Photochemical Elimination Reactions That Proceed Via Triplet Excited State Electrocyclic Ring Closures, Himali Devika Jayasekara Apr 2014

Photochemical Elimination Reactions That Proceed Via Triplet Excited State Electrocyclic Ring Closures, Himali Devika Jayasekara

Master's Theses (2009 -)

Cage compounds have become an important tool for the study of biological processes. The research focuses on new cage compounds that can unmask functional groups present in biologically important molecules such as proteins, peptides, and oligonucleosides. The project focuses on certain functional groups that are often difficult to release photochemically. These are the thiolate groups present in cysteine residues of proteins and peptides. Thiolate groups are fairly basic leaving groups, unlike the more labile groups such as the carboxylates that are present in proteins and peptides, or the phosphate groups present in nucleosides. The research takes advantage of the ability …

Go to article

The Log-Beta Generalized Half-Normal Regression Model, Rodrigo R. Pescim, Edwin M. M. Ortega, Gauss M. Cordeiro, Clarice G. B. Demtrio, Gholamhossein Hamedani Dec 2013

The Log-Beta Generalized Half-Normal Regression Model, Rodrigo R. Pescim, Edwin M. M. Ortega, Gauss M. Cordeiro, Clarice G. B. Demtrio, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

We introduce a log-linear regression model based on the beta generalized half-normal distribution (Pescim et al., 2010). We formulate and develop a log-linear model using a new distribution so-called the log-beta generalized half normal distribution. We derive expansions for the cumulative distribution and density functions which do not depend on complicated functions. We obtain formal expressions for the moments and moment generating function. We characterize the proposed distribution using a simple relationship between two truncated moments. An advantage of the new distribution is that it includes as special sub-models classical distributions reported in the lifetime literature. We also show that …

Go to article

Genomic Analysis Of Stress Response Against Arsenic In Caenorhabditis Elegans, Surasri N. Sahu, Jada Lewis, Isha Patel, Serdar Bozdag, Jeong H. Lee, Robert Sprando, Hediye Nese Cinar Jul 2013

Genomic Analysis Of Stress Response Against Arsenic In Caenorhabditis Elegans, Surasri N. Sahu, Jada Lewis, Isha Patel, Serdar Bozdag, Jeong H. Lee, Robert Sprando, Hediye Nese Cinar

Mathematics, Statistics and Computer Science Faculty Research and Publications

Arsenic, a known human carcinogen, is widely distributed around the world and found in particularly high concentrations in certain regions including Southwestern US, Eastern Europe, India, China, Taiwan and Mexico. Chronic arsenic poisoning affects millions of people worldwide and is associated with increased risk of many diseases including arthrosclerosis, diabetes and cancer. In this study, we explored genome level global responses to high and low levels of arsenic exposure in Caenorhabditis elegans using Affymetrix expression microarrays. This experimental design allows us to do microarray analysis of dose-response relationships of global gene expression patterns. High dose (0.03%) exposure caused stronger global …

Go to article

Neural Correlates Of The Extreme Male Brain Theory In Adolescents With And Without Autism Spectrum Disorders, Audrey Meyer Carson Jul 2013

Neural Correlates Of The Extreme Male Brain Theory In Adolescents With And Without Autism Spectrum Disorders, Audrey Meyer Carson

Dissertations (1934 -)

The Extreme Male Brain (EMB) theory (Baron-Cohen, 2003) is a behavioral theory of autism spectrum disorders (ASD), suggesting that the triad of behavioral impairments in ASD can be conceptualized psychologically as impairment in empathizing, coupled with a superior capacity for systemizing. Despite studies of the behavioral manifestations of this theory, it lacks neurological findings, specifically evidence of less coordinated activity between the left and right hemisphere in ASD (i.e. more lateralized activity). This study attempted to investigate neural correlates of the EMB theory utilizing EEG coherence, an index of neural connectivity, to determine if a more lateralized profile exists in …

Go to article

Expulsion Of Leaving Groups From Zwitterionic Intermediates Generated Via Photochemical Electrocyclic Ring Closure Reactions And An Investigation On Tpe Oligomers, Tasnuva Shahrin Apr 2013

Expulsion Of Leaving Groups From Zwitterionic Intermediates Generated Via Photochemical Electrocyclic Ring Closure Reactions And An Investigation On Tpe Oligomers, Tasnuva Shahrin

Dissertations (1934 -)

Photochemical cleavage reactions have been found widespread use in biological applications that require intracellular photochemical release of biologically active substrates such as peptides, proteins, neurotransmitters, or nucleotide phosphates. The research is to devise photoremovable protecting groups (cage compounds) that can be used to deprotect those biological substrates by irradiation. A number of photocleavage reactions have been developed in recent years which release chlorides, hydroxides, carboxylates, thiolates, and phenolates leaving groups for use in such applications. Nevertheless, photochemical elimination reactions that expel such leaving group anions remain quite uncommon. The cleavage of cage compounds via photolysis requires heterolysis of a bond …

Go to article

Identification Of A Histidine Metal Ligand In The Arge-Encoded N-Acetyl-L-Ornithine Deacetylase From Escherichia Coli, Wade C. Mcgregor, Danuta Gillner, Sabina I. Swierczek, Dali Liu, Richard C. Holz Jan 2013

Identification Of A Histidine Metal Ligand In The Arge-Encoded N-Acetyl-L-Ornithine Deacetylase From Escherichia Coli, Wade C. Mcgregor, Danuta Gillner, Sabina I. Swierczek, Dali Liu, Richard C. Holz

Chemistry Faculty Research and Publications

The H355A, H355K, H80A, and H80K mutant enzymes of the argE-encoded N-acetyl-L-ornithine deacetylase (ArgE) from Escherichia coli were prepared, however, only the H355A enzyme was found to be soluble. Kinetic analysis of the Co(II)-loaded H355A exhibited activity levels that were 380-fold less than Co(II)-loaded WT ArgE. Electronic absorption spectra of Co(II)-loaded H355A-ArgE indicate that the bound Co(II) ion resides in a distorted, five-coordinate environment and Isothermal Titration Calorimetry (ITC) data for Zn(II) binding to the H355A enzyme provided a dissociation constant (Kd) of 39 μM. A three-dimensional homology model of ArgE was generated using the …

Go to article

Photochemical Eilmination Reactions Via Zwitterionic Intermediates Generated By Electrocyclic Ring Closures, Majher Ibna Mannan Sarker Oct 2012

Photochemical Eilmination Reactions Via Zwitterionic Intermediates Generated By Electrocyclic Ring Closures, Majher Ibna Mannan Sarker

Dissertations (1934 -)

The research focuses on the design of photoremovable protecting groups that can be used to deprotect biological substrates of an organic compound by photolysis. The deprotection of the protecting group via photolysis requires heterolysis of a bond to the substrate. Heterolysis of a C-O or C-S σ-bonds in a zwitterionic intermediate is proposed. The photochemical electrocyclic reactions studied involve acrylanilides, benzothiophene carboxanilides, and N-(9-oxothioxanthenyl) benzothiophene carboxamides. α,β-Unsaturated anilides bearing leaving groups at the allylic position of the α-methylacrylamide group undergo photochemical electrocyclic ring closure with release of leaving group which could occur directly from a photochemically produced zwitterionic intermediate or …

Go to article

Methylene Blue Modulates Huntingtin Aggregation Intermediates And Is Protective In Huntington's Disease Models, Emily M. Sontag, Gregor P. Lotz, Namita Agrawal, Andrew Tran, Rebecca Aron, Guocheng Yang, Mihaela Necula, Alice Lau, Steven Finkbeiner, Charles G. Glabe, J. Lawrence Marsh, Paul J. Muchowski, Leslie M. Thompson Aug 2012

Methylene Blue Modulates Huntingtin Aggregation Intermediates And Is Protective In Huntington's Disease Models, Emily M. Sontag, Gregor P. Lotz, Namita Agrawal, Andrew Tran, Rebecca Aron, Guocheng Yang, Mihaela Necula, Alice Lau, Steven Finkbeiner, Charles G. Glabe, J. Lawrence Marsh, Paul J. Muchowski, Leslie M. Thompson

Biological Sciences Faculty Research and Publications

Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-modifying treatments available. The disease is caused by expansion of a CAG trinucleotide repeat and manifests with progressive motor abnormalities, psychiatric symptoms, and cognitive decline. Expression of an expanded polyglutamine repeat within the Huntingtin (Htt) protein impacts numerous cellular processes, including protein folding and clearance. A hallmark of the disease is the progressive formation of inclusions that represent the culmination of a complex aggregation process. Methylene blue (MB), has been shown to modulate aggregation of amyloidogenic disease proteins. We investigated whether MB could impact mutant Htt-mediated aggregation and neurotoxicity. MB …

Go to article

Biomechanics, Brooke A. Slavens, Gerald F. Harris Feb 2012

Biomechanics, Brooke A. Slavens, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Biomechanics is a vast discipline within the field of Biomedical Engineering. It explores the underlying mechanics of how biological and physiological systems move. It encompasses important clinical applications to address questions related to medicine using engineering mechanics principles. Biomechanics includes interdisciplinary concepts from engineers, physicians, therapists, biologists, physicists, and mathematicians. Through their collaborative efforts, biomechanics research is ever changing and expanding, explaining new mechanisms and principles for dynamic human systems. Biomechanics is used to describe how the human body moves, walks, and breathes, in addition to how it responds to injury and rehabilitation. Advanced biomechanical modeling methods, such as inverse …

Go to article

The Utility Of Transient Sensitivity For Wildlife Management And Conservation: Bison As A Case Study, Michael Buhnerkempe, Nathanial Burch, Sarah J. Hamilton, Kerry M. Byrne, Eddie Childers, Kirstin A. Holfelder, Lindsay Mcmanus, Matthew I. Pyne, Greg Schroeder, Paul F. Doherty Jun 2011

The Utility Of Transient Sensitivity For Wildlife Management And Conservation: Bison As A Case Study, Michael Buhnerkempe, Nathanial Burch, Sarah J. Hamilton, Kerry M. Byrne, Eddie Childers, Kirstin A. Holfelder, Lindsay Mcmanus, Matthew I. Pyne, Greg Schroeder, Paul F. Doherty

Mathematics, Statistics and Computer Science Faculty Research and Publications

Developing effective management strategies is essential to conservation biology. Population models and sensitivity analyses on model parameters have provided a means to quantitatively compare different management strategies, allowing managers to objectively assess the resulting impacts. Inference from traditional sensitivity analyses (i.e., eigenvalue sensitivity methods) is only valid for a population at its stable age distribution, while more recent methods have relaxed this assumption and instead focused on transient population dynamics. However, very few case studies, especially in long-lived vertebrates where transient dynamics are potentially most relevant, have applied these transient sensitivity methods and compared them to eigenvalue sensitivity methods. We …

Go to article

Review Of Explanation And Teleology In Aristotle's Science Of Nature By Mariska Leunissen, Owen Goldin Jan 2011

Review Of Explanation And Teleology In Aristotle's Science Of Nature By Mariska Leunissen, Owen Goldin

Philosophy Faculty Research and Publications

No abstract provided.

Go to article

Genome 10k: A Proposal To Obtain Whole-Genome Sequence For 10 000 Vertebrate Species, Tony Gamble, Genome 10k Community Of Scientists Nov 2009

Genome 10k: A Proposal To Obtain Whole-Genome Sequence For 10 000 Vertebrate Species, Tony Gamble, Genome 10k Community Of Scientists

Biological Sciences Faculty Research and Publications

The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and DNA specimens for 10 000 vertebrate species specifically designated for whole-genome sequencing in the very near future. For this purpose, we, the Genome 10K Community of Scientists (G10KCOS), will assemble and allocate a biospecimen collection of some 16 203 representative vertebrate species spanning …

Go to article

Predicting Liana Crown Location From Stem Diameter In Three Panamanian Lowland Forests, Brian P. Kurzel, Stefan A. Schnitzer, Walter P. Carson Mar 2006

Predicting Liana Crown Location From Stem Diameter In Three Panamanian Lowland Forests, Brian P. Kurzel, Stefan A. Schnitzer, Walter P. Carson

Biological Sciences Faculty Research and Publications

In three forests that differed in annual rainfall and seasonality, the probability of a liana with a stem ≥2.0 cm stem diameter reaching the canopy was >50 percent. Lianas reached the canopy at significantly smaller size‐classes (1.5 cm) in the wet aseasonal forest, suggesting that this estimate changes with forest type. Nevertheless, as a general rule, we suggest that 2.0 cm is the minium stem diameter to examine the abundance and diversity of canopy lianas or canopy competition between lianas and trees.

Go to article

The Yeast Rrna Biosynthesis Factor Ebp2p Is Also Required For Efficient Nuclear Division, Costin N. Ionescu, Sofia Origanti, Michael A. Mcalear Oct 2004

The Yeast Rrna Biosynthesis Factor Ebp2p Is Also Required For Efficient Nuclear Division, Costin N. Ionescu, Sofia Origanti, Michael A. Mcalear

Biological Sciences Faculty Research and Publications

Molecular genetic analysis of the yeast Ebp2 protein has revealed that it is an essential, nucleolar protein that functions in the rRNA biosynthesis pathway. Temperature-sensitive ebp2-1 mutants are defective in the processing of the 27 SA precursor rRNA, and the point substitutions that disrupt this activity cluster towards the central, more highly conserved region of the Ebp2 protein. We report here that other ebp2 mutants exhibit deficiencies associated with defects in chromosome segregation. Yeast cells bearing a 50 amino acid C-terminal truncation allele (ebp2ΔC50) display a slow-growth phenotype and exhibit an increased percentage of cells with …

Go to article

The Relationship Between The Fibrinogen D Domain Self-Association/Cross-Linking Site (Gammaxl) And The Fibrinogen Dusart Abnormality (Aalpha R554c-Albumin): Clues To Thrombophilia In The "Dusart Syndrome", Michael W. Mosesson, Kevin R. Siebenlist, James F. Hainfeld, J. S. Wall, C. Soria, J. P. Caen May 1996

The Relationship Between The Fibrinogen D Domain Self-Association/Cross-Linking Site (Gammaxl) And The Fibrinogen Dusart Abnormality (Aalpha R554c-Albumin): Clues To Thrombophilia In The "Dusart Syndrome", Michael W. Mosesson, Kevin R. Siebenlist, James F. Hainfeld, J. S. Wall, C. Soria, J. P. Caen

Biomedical Sciences Faculty Research and Publications

Cross-linking of fibrinogen at its COOH-terminal gamma chain cross-linking site occurs in the presence of factor XIIIa due to self-association at a constitutive D domain site ("gammaXL"). We investigated the contribution of COOH-terminal regions of fibrinogen Aalpha chains to the gammaXL site by comparing the gamma chain cross-linking rate of intact fibrinogen (fraction I-2) with that of plasma fraction I-9, plasmic fraction I-9D, and plasmic fragment D1, which lack COOH-terminal Aalpha chain regions comprising approximately 100, approximately 390, and 413 residues, respectively. The cross-linking rates were I-2 > I-9 > 1-9D = D1, and indicated that the terminal 100 or more Aalpha …

Go to article

Evidence For A Second Type Of Fibril Branch Point In Fibrin Polymer Networks, The Trimolecular Junction, Michael W. Mosesson, James P. Diorio, Kevin R. Siebenlist, Joseph S. Wall, James F. Hainfeld Sep 1993

Evidence For A Second Type Of Fibril Branch Point In Fibrin Polymer Networks, The Trimolecular Junction, Michael W. Mosesson, James P. Diorio, Kevin R. Siebenlist, Joseph S. Wall, James F. Hainfeld

Biomedical Sciences Faculty Research and Publications

Fibrin molecules polymerize to double-stranded fibrils by intermolecular end-to-middle domain pairing of complementary polymerization sites, accompanied by fibril branching to form a clot network. Mass/length measurements on scanning transmission electron microscopic images of fibrils comprising branch points showed two types of junctions. Tetramolecular junctions occur when two fibrils converge, creating a third branch with twice the mass/length of its constituents. Newly recognized trimolecular junctions have three fibril branches of equal mass/length, and occur when an extraneous fibrin molecule initiates branching in a propagating fibril by bridging across two unpaired complementary polymerization sites. When trimolecular junctions predominate, clots exhibit nearly perfect …

Go to article

Effect Of Hindlimb Unweighting On Tissue Blood Flow In The Rat, Kerry S. Mcdonald, M. D. Delp, Robert H. Fitts Jun 1992

Effect Of Hindlimb Unweighting On Tissue Blood Flow In The Rat, Kerry S. Mcdonald, M. D. Delp, Robert H. Fitts

Biological Sciences Faculty Research and Publications

The purpose of this study was to characterize the distribution of blood flow in the rat during hindlimb unweighting (HU) and post-HU standing and exercise and examine whether the previously reported (Witzmann et al., J. Appl. Physiol. 54: 1242–1248, 1983) elevation in anaerobic metabolism observed with contractile activity in the atrophied soleus muscle was caused by a reduced hindlimb blood flow. After either 15 days of HU or cage control, blood flow was measured with radioactive microspheres during unweighting, normal standing, and running on a treadmill (15 m/min). In another group of control and experimental animals, blood flow was measured …

Go to article

The Effects Of X-Rays And Beta Rays (Tritium) On The Growth Of Rickettsia Mooseri And Rickettsia Akari In Embryonate Eggs, Donald Greiff, E. L. Powers, Walter E. Kisieleski, Henry Pinkerton Jun 1960

The Effects Of X-Rays And Beta Rays (Tritium) On The Growth Of Rickettsia Mooseri And Rickettsia Akari In Embryonate Eggs, Donald Greiff, E. L. Powers, Walter E. Kisieleski, Henry Pinkerton

Biomedical Sciences Faculty Research and Publications

The growth of Rickettsia mooseri was accelerated and quantitatively increased in embryonate eggs containing tritium oxide at levels of 180, 90, and 45 mc./egg during the growth period. The eggs of a group containing 22.5 mc./egg showed only a slight increase in the rate of growth of organisms; the infections in the eggs of a group given 11.2 mc./egg did not differ significantly from those of the control group. On the other hand, growth of R. akari was inhibited in embryonate eggs containing tritium oxide at levels of 180, 90, and 45 mc./egg, and partially inhibited in groups containing 22.5 …

Go to article

The Content Of The High School Biology Course, Paul A. Geenen Apr 1933

The Content Of The High School Biology Course, Paul A. Geenen

Bachelors’ Theses

Ignorance is bliss. Perhaps it is ignorance which prompts youth to attempt problems which the united efforts of experts and specialists have failed to conquer completely. However, there must be one "first attempt"; perhaps the first futile trials will eventually lead to something really worthwhile. This thesis is an attempt to help solve an almost insoluble problem: "What should be included in the high school biology course to give the best results." The work is based very largely on the results of those who have wrestled with the problem and emerged with new ideas; it is an effort to present …

Go to article

The Human Soul Is Simple, Spiritual, Immortal, Robert S. Mccarthy May 1922

The Human Soul Is Simple, Spiritual, Immortal, Robert S. Mccarthy

Bachelors’ Theses

Much of our thinking today is regulated by propaganda. Propaganda is not confined to patriotic bureaus of any one nation, or to the espionage department of the army and navy of any one government; neither is propaganda limited to national affairs, nor to the field of politics. Propaganda of a certain type has found its way even into the sacred sanctum of philosophy. Think of how many philosophical theories we have today, which in final analysis are intended to serve the purpose of a well-directed campaign of proselytising "right thinking". Theories arising from predjudiced minds are spread broadcast, whose mission …

Go to article

First Prev