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Rapid Evaluation And Optimization Of Carbon Dioxide-Enhanced Oil Recovery Using Reduced-Physics Proxy Models, Watheq J. Al-Mudhafar, Dandina N. Rao, Sanjay Srinivasan, Hung Vo Thanh, Erfan M. Al Lawe Oct 2022

Rapid Evaluation And Optimization Of Carbon Dioxide-Enhanced Oil Recovery Using Reduced-Physics Proxy Models, Watheq J. Al-Mudhafar, Dandina N. Rao, Sanjay Srinivasan, Hung Vo Thanh, Erfan M. Al Lawe

Faculty Publications

The carbon dioxide (CO2) injection in oil reservoirs is a promising enhanced oil recovery method to reduce carbon emissions into the atmosphere. The CO2 injection simulation and optimization require a large computation time, especially in real large-scale oil reservoirs. This paper integrates experimental design and machine learning to construct a reduced-physics surrogate model alternative to the complex reservoir simulator. This surrogate model was used to evaluate and optimize the CO2-assisted gravity drainage (CO2-GAGD) process, applied to a clastic reservoir in the Rumaila oil field. In the GAGD process optimization, five operational decision parameters controlling the production and injection activities were …

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Permeable Curbs For Storm Water Pollution, Aldo Hernandez, Drew Johnson, Marcio Giacomoni Oct 2022

Permeable Curbs For Storm Water Pollution, Aldo Hernandez, Drew Johnson, Marcio Giacomoni

Publications

One of the problems that increased urbanization poses is storm water pollution. Several control measures exist that are used to treat and reduce pollution in our waterways, one of those being permeable concretes; but these have not been widely adopted. The goal of this project was to develop a permeable curb apparatus that could be used in retrofitting conventional streets. The permeable curb is comprised of a permeable concrete mix with a perforated pipe running through its center, this allows for water to filter through the porous concrete and continue downstream through the perforated pipe which would eventually lead to …

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Measuring The Effect Of Bipartisan Support For Foreign Policy Initiatives In The Senate On U.S. Policy Success, Emily Fitkin Oct 2022

Measuring The Effect Of Bipartisan Support For Foreign Policy Initiatives In The Senate On U.S. Policy Success, Emily Fitkin

Honors Capstones

No abstract provided.

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Signatures Of Multiband Effects In High-Harmonic Generation In Monolayer Mos2, Lun Yue, Richard Hollinger, Can B. Uzundal, Bailey Nebgen, Ziyang Gan, Emad Najafidehaghani, Antony George, Christian Spielmann, Daniil Kartashov, Andrey Turchanin, Diana Y. Qiu, Mette B. Gaarde, Michael Zuerch Sep 2022

Signatures Of Multiband Effects In High-Harmonic Generation In Monolayer Mos2, Lun Yue, Richard Hollinger, Can B. Uzundal, Bailey Nebgen, Ziyang Gan, Emad Najafidehaghani, Antony George, Christian Spielmann, Daniil Kartashov, Andrey Turchanin, Diana Y. Qiu, Mette B. Gaarde, Michael Zuerch

Faculty Publications

High-harmonic generation (HHG) in solids has been touted as a way to probe ultrafast dynamics and crystal symmetries in condensed matter systems. Here, we investigate the polarization properties of high-order harmonics generated in monolayer MoS2, as a function of crystal orientation relative to the mid-infrared laser field polarization. At several different laser wavelengths we experimentally observe a prominent angular shift of the parallel-polarized odd harmonics for energies above approximately 3.5 eV, and our calculations indicate that this shift originates in subtle differences in the recombination dipole strengths involving multiple conduction bands. This observation is material specific and is in addition …

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Quantization Of The Boolean Poisson Central Limit Theorem And A Generalized Boolean Bernoulli Sequence, Yungang Lu Sep 2022

Quantization Of The Boolean Poisson Central Limit Theorem And A Generalized Boolean Bernoulli Sequence, Yungang Lu

Journal of Stochastic Analysis

No abstract provided.

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Hd-Tdcs Of Primary And Higher-Order Motor Cortex Affects Action Word Processing, Karim Johari, Nicholas Riccardi, Svetlana Malyutina, Mirage Modi, Rutvik H. Desai Sep 2022

Hd-Tdcs Of Primary And Higher-Order Motor Cortex Affects Action Word Processing, Karim Johari, Nicholas Riccardi, Svetlana Malyutina, Mirage Modi, Rutvik H. Desai

Faculty Publications

The contribution of action-perception systems of the brain to lexical semantics remains controversial. Here, we used high-definition transcranial direct current stimulation (HD-tDCS) in healthy adults to examine the role of primary (left hand motor area; HMA) and higher-order (left anterior inferior parietal lobe; aIPL) action areas in action-related word processing (action verbs and manipulable nouns) compared to non-action-related control words (non-action verbs and non-manipulable nouns). We investigated stimulation-related effects at three levels of semantic processing: subliminal, implicit, and explicit. Broadly, we found that stimulation of HMA and aIPL resulted in relative facilitation of action-related language processing compared to non-action. HMA …

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The Impact Of Social Support Sources On Lgbtq Adolescents, Kaitlyn C. Mccauley Sep 2022

The Impact Of Social Support Sources On Lgbtq Adolescents, Kaitlyn C. Mccauley

LSU Master's Theses

Research demonstrates that adolescents social support plays an important role in protecting against adverse events (e.g., Brewin & MacCarthy, 1989; Muzik et al., 2017). LGBQ adolescents have been shown to experience greater adverse experiences such a daily microaggressions and higher rates of both childhood adversity (Baams, 2018) and peer victimization (Kosciw et al., 2014). Increased stressors often lead to poorer outcomes in this population. Social support research for adolescents has shown that different sources of social support have shown to buffer these reported issues (e.g., greater parent and peer support buffers suicidal ideation, Fredrick et al., 2018). Studies with LGBQ …

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A Numerical Reassessment Of The Gulf Of Mexico Carbon System In Connection With The Mississippi River And Global Ocean, Le Zhang, Z. George Xue Sep 2022

A Numerical Reassessment Of The Gulf Of Mexico Carbon System In Connection With The Mississippi River And Global Ocean, Le Zhang, Z. George Xue

Faculty Publications

Coupled physical-biogeochemical models can fill the spatial and temporal gap in ocean carbon observations. Challenges of applying a coupled physical-biogeochemical model in the regional ocean include the reasonable prescription of carbon model boundary conditions, lack of in situ observations, and the oversimplification of certain biogeochemical processes. In this study, we applied a coupled physical-biogeochemical model (Regional Ocean Modelling System, ROMS) to the Gulf of Mexico (GoM) and achieved an unprecedented 20-year high-resolution (5 km, 1/22°) hindcast covering the period of 2000 to 2019. The biogeochemical model incorporated the dynamics of dissolved organic carbon (DOC) pools and the formation and dissolution …

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Responses Of Phytoplankton Communities Driven By Differences Of Source Water Intrusions In The El Niño And La Niña Events In The Taiwan Strait During The Early Spring, Yanping Zhong, Edward A. Laws, Jiafu Zhuang, Jingxiao Wang, Peixuan Wang, Caiyun Zhang, Xin Liu, Bangqin Huang Sep 2022

Responses Of Phytoplankton Communities Driven By Differences Of Source Water Intrusions In The El Niño And La Niña Events In The Taiwan Strait During The Early Spring, Yanping Zhong, Edward A. Laws, Jiafu Zhuang, Jingxiao Wang, Peixuan Wang, Caiyun Zhang, Xin Liu, Bangqin Huang

Faculty Publications

The El Niño Southern Oscillation (ENSO) is one of the most important drivers of interannual variations of marine ecosystems, especially monsoonal ecosystems. The channel effect in a strait amplifies the impact of monsoons and may be an ideal area to study ecosystem responses to ENSO events. Previous studies have shown that physical processes in the Taiwan Strait (TWS) vary during the different ENSO phases, but the biological responses are still unclear. In this study, we found clear differences in the physical, chemical, and biological characteristics of the TWS between different ENSO phases based on data from satellites and field cruises …

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A First-Passage Problem For Exponential Integrated Diffusion Processes, Mario Lefebvre Sep 2022

A First-Passage Problem For Exponential Integrated Diffusion Processes, Mario Lefebvre

Journal of Stochastic Analysis

No abstract provided.

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Applications Of A Patient-Specific Whole-Body Ct-Mesh Hybrid Computational Phantom In Second Cancer Risk Prediction, Erika Kollitz, Moritz Roew, Haegin Han, Marco Pinto, Florian Kamp, Chan Hyeong Kim, Marco Schwarz, Claus Belka, Wayne Newhauser, Katia Parodi, George Dedes Sep 2022

Applications Of A Patient-Specific Whole-Body Ct-Mesh Hybrid Computational Phantom In Second Cancer Risk Prediction, Erika Kollitz, Moritz Roew, Haegin Han, Marco Pinto, Florian Kamp, Chan Hyeong Kim, Marco Schwarz, Claus Belka, Wayne Newhauser, Katia Parodi, George Dedes

Faculty Publications

Objective. CT-mesh hybrid phantoms (or ‘hybrid(s)’) made from integrated patient CT data and mesh-type reference computational phantoms (MRCPs) can be beneficial for patient-specific whole-body dose evaluation, but this benefit has yet to be evaluated for second cancer risk prediction. The purpose of this study is to compare the hybrid’s ability to predict risk throughout the body with a patient-scaled MRCP against ground truth whole-body CTs (WBCTs). Approach. Head and neck active scanning proton treatment plans were created for and simulated on seven hybrids and the corresponding scaled MRCPs and WBCTs. Equivalent dose throughout the body was calculated and input into …

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Editorial: Quantum Light For Imaging, Sensing And Spectroscopy, Roberto De J. León-Montiel, Mario A. Quiroz-Juárez, Omar S. Magaña-Loaiza, Juan P. Torres Sep 2022

Editorial: Quantum Light For Imaging, Sensing And Spectroscopy, Roberto De J. León-Montiel, Mario A. Quiroz-Juárez, Omar S. Magaña-Loaiza, Juan P. Torres

Faculty Publications

No abstract provided.

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Unsupervised Summarization Of Privacy Concerns In Mobile Application Reviews, Fahimeh Ebrahimi, Anas Mahmoud Sep 2022

Unsupervised Summarization Of Privacy Concerns In Mobile Application Reviews, Fahimeh Ebrahimi, Anas Mahmoud

Faculty Publications

The proliferation of mobile applications (app) over the past decade has imposed unprecedented challenges on end-users privacy. Apps constantly demand access to sensitive user information in exchange for more personalized services. These - mostly unjustifiable - data collection tactics have raised major privacy concerns among mobile app users. Such concerns are commonly expressed in mobile app reviews, however, they are typically overshadowed by more generic categories of user feedback, such as app reliability and usability. This makes extracting user privacy concerns manually, or even using automated tools, a challenging and time-consuming task. To address these challenges, in this paper, we …

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Degumming Of Hemp Fibers Using Combined Microwave Energy And Deep Eutectic Solvent Treatment, Bulbul Ahmed, Qinglin Wu, Hai Lin, Jaegyoung Gwon, Ioan Negulescu, Bruce Cameron Sep 2022

Degumming Of Hemp Fibers Using Combined Microwave Energy And Deep Eutectic Solvent Treatment, Bulbul Ahmed, Qinglin Wu, Hai Lin, Jaegyoung Gwon, Ioan Negulescu, Bruce Cameron

Faculty Publications

Hemp bast fibers were degummed using combined microwave energy (MWE) and deep eutectic solvent (DES) to generate pure hemp cellulose fibers for potential textile applications. The properties of the degummed fibers were investigated and compared with those of the alkali-treated fibers using several analytical techniques. Results revealed that hemp fiber surface underwent dramatic structural disruption during the pretreatment, due to the removal of “gummy” compounds (i.e., pectin, oil, wax, etc.), lignin, and amorphous cellulose. The treated fibers had much enhanced thermal stability due to the removal of the gummy materials. The reduced enthalpy (171.34 J/g) of MWE-DES treated fibers at …

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Pest Population Dynamics Are Related To A Continental Overwintering Gradient, Douglas Lawton, Anders S. Huseth, George G. Kennedy, Amy C. Morey, William D. Hutchison, Dominic D. Reisig, Seth J. Dorman, De Shae Dillard, Robert C. Venette, Russell L. Groves, John J. Adamczyk, Izailda Barbosa Dos Santos, Tracey Baute, Sebe Brown, Eric Burkness, Ashley Dean, Galen P. Dively, Hélène B. Doughty, Shelby J. Fleischer, Jessica Green, Jeremy K. Greene, Krista Hamilton, Erin Hodgson, Thomas Hunt, David Kerns, Billy Rogers Leonard, Sean Malone, Fred Musser, David Owens, John C. Palumbo, Silvana Paula-Moraes, Julie A. Peterson, Ricardo Ramirez Sep 2022

Pest Population Dynamics Are Related To A Continental Overwintering Gradient, Douglas Lawton, Anders S. Huseth, George G. Kennedy, Amy C. Morey, William D. Hutchison, Dominic D. Reisig, Seth J. Dorman, De Shae Dillard, Robert C. Venette, Russell L. Groves, John J. Adamczyk, Izailda Barbosa Dos Santos, Tracey Baute, Sebe Brown, Eric Burkness, Ashley Dean, Galen P. Dively, Hélène B. Doughty, Shelby J. Fleischer, Jessica Green, Jeremy K. Greene, Krista Hamilton, Erin Hodgson, Thomas Hunt, David Kerns, Billy Rogers Leonard, Sean Malone, Fred Musser, David Owens, John C. Palumbo, Silvana Paula-Moraes, Julie A. Peterson, Ricardo Ramirez

Faculty Publications

Overwintering success is an important determinant of arthropod populations that must be considered as climate change continues to influence the spatiotemporal population dynamics of agricultural pests. Using a long-term monitoring database and biologically relevant overwintering zones, we modeled the annual and seasonal population dynamics of a common pest, Helicoverpa zea (Boddie), based on three overwintering suitability zones throughout North America using four decades of soil temperatures: the southern range (able to persist through winter), transitional zone (uncertain overwintering survivorship), and northern limits (unable to survive winter). Our model indicates H. zea population dynamics are hierarchically structured with continental-level effects that …

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The Matricellular Protein Sparc Induces Inflammatory Interferon-Response In Macrophages During Aging, Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit Sep 2022

The Matricellular Protein Sparc Induces Inflammatory Interferon-Response In Macrophages During Aging, Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit

Clinical Research Faculty Publications

The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein acidic and rich in cysteine (SPARC), was inhibited by 2 years of 14% sustained CR in humans and elevated by obesity. SPARC converted anti-inflammatory macrophages into a pro-inflammatory phenotype with induction of interferon-stimulated gene (ISG) expression via the transcription factors IRF3/7. Mechanistically, SPARC-induced ISGs were dependent on toll-like receptor-4 (TLR4)-mediated TBK1, IRF3, IFN-β, and STAT1 signaling without engaging the Myd88 pathway. Metabolically, SPARC dampened mitochondrial respiration, and inhibition of glycolysis abrogated ISG induction by SPARC …

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A Comparison Of Intertidal Metazoan Biodiversity Among Different Salinity Zones Of Louisiana Coastal Marshes, Claudia Husseneder, Patrick Rayle, Benjamin G. Aker, W. Kelley Thomas, Lane D. Foil Sep 2022

A Comparison Of Intertidal Metazoan Biodiversity Among Different Salinity Zones Of Louisiana Coastal Marshes, Claudia Husseneder, Patrick Rayle, Benjamin G. Aker, W. Kelley Thomas, Lane D. Foil

Faculty Publications

Tidal marshes are among the most valuable, productive, and vulnerable ecosystems with high biodiversity. Louisiana’s saltmarshes are endangered by natural and man-made stressors, including oil pollution, saltwater intrusion, and land loss due to sea level rise and erosion. Freshwater diversions have been planned to restore sediment input from the Mississippi River to rebuild marsh habitats in South Louisiana. These proposed diversions will undoubtedly change salinity levels, which is a major controlling factor in the distribution of marsh organisms, including those in soil; however, detailed pre-event inventories are lacking. This study describes the diversity of metazoan meiofauna (organisms between 45 and …

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Discovery And Validation Of Grain Shape Loci In U.S. Rice Germplasm Through Haplotype Characterization, Brijesh Angira, Tommaso Cerioli, Adam N. Famoso Sep 2022

Discovery And Validation Of Grain Shape Loci In U.S. Rice Germplasm Through Haplotype Characterization, Brijesh Angira, Tommaso Cerioli, Adam N. Famoso

Faculty Publications

Rice grain shape is a major determinant of rice market value and the end-use. We mapped quantitative trait loci (QTL) for grain shape traits in a bi-parental recombinant inbred line population (Trenasse/Jupiter) and discovered two major grain length QTLs—qGL3.1 and qGL7.1. Previously, a major grain shape gene GS3 was reported in the qGL3.1 region and grain length gene GL7 was reported to be encompassing qGL7.1 locus. The re-sequencing SNP data on the International Rice Research Institute (IRRI) 3K Rice Genome Project (RGP) panel were obtained from the IRRI SNP-Seek database for both genes and haplotype diversity was characterized for each …

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Resonant Plasmonic–Biomolecular Chiral Interactions In The Far-Ultraviolet: Enantiomeric Discrimination Of Sub-10 Nm Amino Acid Films, Tiago Ramos Leite, Lin Zschiedrich, Orhan Kizilkaya, Kevin M. Mcpeak Sep 2022

Resonant Plasmonic–Biomolecular Chiral Interactions In The Far-Ultraviolet: Enantiomeric Discrimination Of Sub-10 Nm Amino Acid Films, Tiago Ramos Leite, Lin Zschiedrich, Orhan Kizilkaya, Kevin M. Mcpeak

Faculty Publications

Resonant plasmonic–molecular chiral interactions are a promising route to enhanced biosensing. However, biomolecular optical activity primarily exists in the far-ultraviolet regime, posing significant challenges for spectral overlap with current nano-optical platforms. We demonstrate experimentally and computationally the enhanced chiral sensing of a resonant plasmonic–biomolecular system operating in the far-UV. We develop a full-wave model of biomolecular films on Al gammadion arrays using experimentally derived chirality parameters. Our calculations show that detectable enhancements in the chiroptical signals from small amounts of biomolecules are possible only when tight spectral overlap exists between the plasmonic and biomolecular chiral responses. We support this conclusion …

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Stereoisomers Of An Aryl Pyrazole Glucocorticoid Receptor Agonist Scaffold Elicit Differing Anti-Inflammatory Responses, Ashley M. Lato, Susan J. Burke, Maggie P. Ducote, Brandon J. Kennedy, J. Jason Collier, Shawn R. Campagna Sep 2022

Stereoisomers Of An Aryl Pyrazole Glucocorticoid Receptor Agonist Scaffold Elicit Differing Anti-Inflammatory Responses, Ashley M. Lato, Susan J. Burke, Maggie P. Ducote, Brandon J. Kennedy, J. Jason Collier, Shawn R. Campagna

Division of Basic Science Faculty Publications

Glucocorticoids (GCs) are heavily prescribed to control inflammation in various human diseases; however, side effects associated with GCs are well documented and lead to serious metabolic and immunological complications with long-term use. The paradigm for GC function includes two well described modes of activity: dimer formation of the glucocorticoid receptor (GR) promotes transactivation, while monomeric interaction with co-regulators promotes transrepression. Previously, a set of aryl pyrazole-derived glucocorticoid receptor agonists (APGRAs) with potency rivaling current commercially available glucocorticoids were described. In this study, a further series of existing and novel stereopure APGRAs were thoroughly examined for biological activity and evaluated for …

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Effects Of Sensory Cues On Product Acceptability And Consumer Perceptions, Emotions, And Behavior, Cristhiam Gurdian Curran Sep 2022

Effects Of Sensory Cues On Product Acceptability And Consumer Perceptions, Emotions, And Behavior, Cristhiam Gurdian Curran

LSU Doctoral Dissertations

Visual and cognitive cues can affect overall liking (OL) and consumer perceptions, emotions, and behavior. The first study explored the effect of product color difference on the liking, perception, and purchase intent (PI) of cheese-flavored-tortilla chips (CFTC) formulations (A and B) on serving plates (plastic, foam, and paper). Color differences between formulations influenced crunchiness and saltiness liking and perception, which together with overall flavor liking and formulation, mainly determined CFTC OL. Although having similar fracturability (N) and sodium content, formulation A had higher crunchiness and saltiness likings. PI was influenced by crunchiness, saltiness, and OF liking with 37, 49, and …

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Impact Of Extreme Heatwaves On Population Exposure In China Due To Additional Warming, Leibin Wang, Robert V. Rohli, Qigen Lin, Shaofei Jin, Xiaodong Yan Sep 2022

Impact Of Extreme Heatwaves On Population Exposure In China Due To Additional Warming, Leibin Wang, Robert V. Rohli, Qigen Lin, Shaofei Jin, Xiaodong Yan

Faculty Publications

Extreme heatwaves are among the most important climate-related disasters affecting public health. Assessing heatwave-related population exposures under different warming scenarios is critical for climate change adaptation. Here, the Coupled Model Intercomparison Project phase 6 (CMIP6) multi-model ensemble output results are applied over several warming periods in the Intergovernmental Panel on Climate Change AR6 report, to estimate China’s future heatwave population exposure under 1.5 °C and 2.0 °C warming scenarios. Our results show a significant increase in projected future annual heatwave days (HD) under both scenarios. With an additional temperature increase of 0.5 °C to 2.0 °C of warming, by mid-century …

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Advances In Research And Applications Of Co2-Based Demand-Controlled Ventilation In Commercial Buildings: A Critical Review Of Control Strategies And Performance Evaluation, Xing Lu, Zhihong Pang, Yangyang Fu, Zheng O'Neill Sep 2022

Advances In Research And Applications Of Co2-Based Demand-Controlled Ventilation In Commercial Buildings: A Critical Review Of Control Strategies And Performance Evaluation, Xing Lu, Zhihong Pang, Yangyang Fu, Zheng O'Neill

Faculty Publications

The carbon dioxide (CO2)-based demand-controlled ventilation (DCV) has attracted prompt attention from the Heating, Ventilation, and Air-Conditioning (HVAC) industry since its very first invention. Thereafter it has gone through several revolutions due to the rapid advancement in control and sensing technologies. Although a great variety of CO2-based DCV control strategies have been developed in the last two decades, there lacks a holistic literature review that systematically analyzes and summarizes advances and applications of CO2-based DCV in commercial buildings. This paper examines the recent advances in the CO2-based DCV in commercial buildings and focuses on discussing the control-related issues in the …

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The Double-Edged Sword Of Safety Training For Safety Behavior: The Critical Role Of Psychological Factors During Covid-19, Xin Ning, Jiwen Huang, Chunlin Wu, Tong Liu, Chao Wang Sep 2022

The Double-Edged Sword Of Safety Training For Safety Behavior: The Critical Role Of Psychological Factors During Covid-19, Xin Ning, Jiwen Huang, Chunlin Wu, Tong Liu, Chao Wang

Faculty Publications

Safety training (ST) is the primary means of avoiding unsafe behaviors, but it has not achieved the expected impact on improving workplace safety because of the high psychological stress it brings to workers. The coronavirus disease 2019 (COVID-19) further threatens workers’ psychological conditions, thereby diminishing the effectiveness of ST. However, the existing literature has mainly laid emphasis on the bright side of ST and neglected examining its impact on safety behavior (SB) from detrimental psychological factors. Drawing from the conservation of resources theory, a novel two-staged model was established to understand how these psychological factors mediate and moderate the association …

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Endothelin-1 As A Novel Target For The Prevention Of Metabolic Dysfunction With Intermittent Hypoxia In Male Participants, Jacqueline K. Limberg, Sarah E. Baker, Humphrey G. Petersen-Jones, Winston Guo, An Huang, Michael D. Jensen, Prachi Singh Sep 2022

Endothelin-1 As A Novel Target For The Prevention Of Metabolic Dysfunction With Intermittent Hypoxia In Male Participants, Jacqueline K. Limberg, Sarah E. Baker, Humphrey G. Petersen-Jones, Winston Guo, An Huang, Michael D. Jensen, Prachi Singh

Clinical Research Faculty Publications

We examined the effect of intermittent hypoxia (IH, a hallmark feature of sleep apnea) on adipose tissue lipolysis and the role of endothelin-1 (ET-1) in this response. We hypothesized that IH can increase ET-1 secretion and plasma free fatty acid (FFA) concentrations. We further hypothesized that inhibition of ET-1 receptor activation with bosentan could prevent any IH-mediated increase in FFA. To test this hypothesis, 16 healthy male participants (32 ± 5 yr, 26 ± 2 kg/m2) were exposed to 30 min of IH in the absence (control) and presence of bosentan (62.5 mg oral twice daily for 3 days prior). …

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Comparative Efficacy Of A Fungal Entomopathogen With A Broad Host Range Against Two Human-Associated Pests, Aaron R. Ashbrook, Aram Mikaelyan, Coby Schal Sep 2022

Comparative Efficacy Of A Fungal Entomopathogen With A Broad Host Range Against Two Human-Associated Pests, Aaron R. Ashbrook, Aram Mikaelyan, Coby Schal

Faculty Publications

The ability of a fungal entomopathogen to infect an insect depends on a variety of factors, including strain, host, and environmental conditions. Similarly, an insect’s ability to prevent fungal infection is dependent on its biology, environment, and evolutionary history. Synanthropic pests have adapted to thrive in the indoor environment, yet they arose from divergent evolutionary lineages and occupy different feeding guilds. The hematophagous bed bug (Cimex lectularius) and omnivorous German cockroach (Blattella germanica) are highly successful indoors, but have evolved different physiological and behavioral adaptations to cope with the human-built environment, some of which also reduce the efficacy of fungal …

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Sci: A Bayesian Adaptive Phase I/Ii Dose-Finding Design Accounting For Semi-Competing Risks Outcomes For Immunotherapy Trials, Yifei Zhang, Beibei Guo, Sha Cao, Chi Zhang, Yong Zang Sep 2022

Sci: A Bayesian Adaptive Phase I/Ii Dose-Finding Design Accounting For Semi-Competing Risks Outcomes For Immunotherapy Trials, Yifei Zhang, Beibei Guo, Sha Cao, Chi Zhang, Yong Zang

Faculty Publications

An immunotherapy trial often uses the phase I/II design to identify the optimal biological dose, which monitors the efficacy and toxicity outcomes simultaneously in a single trial. The progression-free survival rate is often used as the efficacy outcome in phase I/II immunotherapy trials. As a result, patients developing disease progression in phase I/II immunotherapy trials are generally seriously ill and are often treated off the trial for ethical consideration. Consequently, the happening of disease progression will terminate the toxicity event but not vice versa, so the issue of the semi-competing risks arises. Moreover, this issue can become more intractable with …

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Redox-Engineering Enhances Maize Thermotolerance And Grain Yield In The Field, Stuart A. Sprague, Tej Man Tamang, Trevor Steiner, Qingyu Wu, Ying Hu, Tayebeh Kakeshpour, Jungeun Park, Jian Yang, Zhao Peng, Blake Bergkamp, Impa Somayanda, Morgan Peterson, Ely Oliveira Garcia, Yangfan Hao, Paul St. Amand, Guihua Bai, Paul A. Nakata, Ivo Rieu, David P. Jackson, Ninghui Cheng, Barbara Valent, Kendal D. Hirschi, Sv Krishna Jagadish, Sanzhen Liu, Frank F. White, Sunghun Park Sep 2022

Redox-Engineering Enhances Maize Thermotolerance And Grain Yield In The Field, Stuart A. Sprague, Tej Man Tamang, Trevor Steiner, Qingyu Wu, Ying Hu, Tayebeh Kakeshpour, Jungeun Park, Jian Yang, Zhao Peng, Blake Bergkamp, Impa Somayanda, Morgan Peterson, Ely Oliveira Garcia, Yangfan Hao, Paul St. Amand, Guihua Bai, Paul A. Nakata, Ivo Rieu, David P. Jackson, Ninghui Cheng, Barbara Valent, Kendal D. Hirschi, Sv Krishna Jagadish, Sanzhen Liu, Frank F. White, Sunghun Park

Faculty Publications

Increasing populations and temperatures are expected to escalate food demands beyond production capacities, and the development of maize lines with better performance under heat stress is desirable. Here, we report that constitutive ectopic expression of a heterologous glutaredoxin S17 from Arabidopsis thaliana (AtGRXS17) can provide thermotolerance in maize through enhanced chaperone activity and modulation of heat stress-associated gene expression. The thermotolerant maize lines had increased protection against protein damage and yielded a sixfold increase in grain production in comparison to the non-transgenic counterparts under heat stress field conditions. The maize lines also displayed thermotolerance in the reproductive stages, resulting in …

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Effect Of Two Strains Of Beauveria Bassiana On The Fecundity Of Nezara Viridula L. (Heteroptera: Pentatomidae), Maribel Portilla, Gadi V.P. Reddy, Moukaram Tertuliano Sep 2022

Effect Of Two Strains Of Beauveria Bassiana On The Fecundity Of Nezara Viridula L. (Heteroptera: Pentatomidae), Maribel Portilla, Gadi V.P. Reddy, Moukaram Tertuliano

Faculty Publications

The southern green stink bug (SGSB) Nezara viridula (L.) (Heteroptera: Pentatomidae), has become a significant pest of soybean and cotton in southern Central America and in the lower mid-southern U.S. A laboratory colony of SGSB was used to evaluate the effect of two isolates of Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitaceae) including the commercial strain GHA and the Mississippi Delta native NI8 strain on the fecundity of this pest. Water control, Tween-80, and four concentrations of each strain (n × 104, 105, 106, and 107) were evaluated. Both native and commercial isolates with the highest concentrations were susceptible to the …

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Susceptibility Of Different Life Stages Of Kudzu Bug Megacopta Cribraria (F.) (Hemiptera: Plataspidae) To Two Different Native Strains Of Beauveria Bassiana, James Paul Glover, Maribel Portilla, Katherine Parys, Clint Allen, Justin George, Gadi V.P. Reddy Sep 2022

Susceptibility Of Different Life Stages Of Kudzu Bug Megacopta Cribraria (F.) (Hemiptera: Plataspidae) To Two Different Native Strains Of Beauveria Bassiana, James Paul Glover, Maribel Portilla, Katherine Parys, Clint Allen, Justin George, Gadi V.P. Reddy

Faculty Publications

This is the first study that examined and compared the survival, LC50, and RR50 estimates of Megacopta cribraria F. (Hemiptera: Plataspidae) nymphs and adults that were exposed to two native Beauveria bassiana isolates (Previously codified as NI8 and KUDSC strains) at four concentrations. The greatest reduction in survival and mortality was observed primarily on or after 10 d post-exposure to B. bassiana isolates. Survival of early instars (2nd, 3rd) were not affected by either strains or concentration at 3 d and 5 d post-exposure. Survival of later instars (5th) and adults was significantly reduced when exposed to the KUDSC strain …

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