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Non-Quasiconvex Subgroups Of Hyperbolic Groups Via Stallings-Like Techniques, Pallavi Dani, Ivan Levcovitz Feb 2023

Non-Quasiconvex Subgroups Of Hyperbolic Groups Via Stallings-Like Techniques, Pallavi Dani, Ivan Levcovitz

Faculty Publications

We provide a new method of constructing non-quasiconvex subgroups of hyperbolic groups by utilizing techniques inspired by Stallings’ foldings. The hyperbolic groups constructed are in the natural class of right-angled Coxeter groups (RACGs for short) and can be chosen to be 2-dimensional. More specifically, given a non-quasiconvex subgroup of a (possibly non-hyperbolic) RACG, our construction gives a corresponding non-quasiconvex subgroup of a hyperbolic RACG. We use this to construct explicit examples of non-quasiconvex subgroups of hyperbolic RACGs including subgroups whose generators are as short as possible (length two words), finitely generated free subgroups, non-finitely presentable subgroups, and subgroups of fundamental …

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Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa Feb 2023

Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa

Faculty Publications

Linking high-throughput environmental data (enviromics) to genomic prediction (GP) is a cost-effective strategy for increasing selection intensity under genotype-by-environment interactions (G × E). This study developed a data-driven approach based on Environment–Phenotype Association (EPA) aimed at recycling important G × E information from historical breeding data. EPA was developed in two applications: (1) scanning a secondary source of genetic variation, weighted from the shared reaction-norms of past-evaluated genotypes and (2) pinpointing weights of the similarity among trial-sites (locations), given the historical impact of each envirotyping data variable for a given site. These results were then used as a dimensionality reduction …

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Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas Feb 2023

Discovery Of Novel Bioactive Tanshinones And Carnosol Analogues Against Breast Cancer, Miguel A. González-Cardenete, Natalia González-Zapata, Lucinda Boyd, Fatima Rivas

Faculty Publications

The abietane diterpenoids ferruginol (1), tanshinone IIA (3), and carnosol (4) are well-known for their interesting pharmacological properties, including antitumor, similar to other natural and semisynthetic abietanes. In this study, a pair of semisynthetic C18-functionalized analogues of 3 and 4 were prepared from the commercially available (+)-dehydroabietylamine or readily obtained methyl dehydroabietate. Semisynthetic ferruginol (1) and some selected analogues, together with the synthesized analogues, were tested in vitro for the inhibition of proliferation in four breast cancer cell lines, SUM149, MDA-MB231, T47D, and MCF07. As a result, several tested abietane analogues decreased cell proliferation and enhanced cell death, with IC50 …

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Inactivation Of The Ul37 Deamidase Enhances Virus Replication And Spread Of The Hsv-1(Vc2) Oncolytic Vaccine Strain And Secretion Of Gm-Csf, Carolyn M. Clark, Nithya Jambunathan, Therese M.A. Collantes, Konstantin G. Kousoulas Feb 2023

Inactivation Of The Ul37 Deamidase Enhances Virus Replication And Spread Of The Hsv-1(Vc2) Oncolytic Vaccine Strain And Secretion Of Gm-Csf, Carolyn M. Clark, Nithya Jambunathan, Therese M.A. Collantes, Konstantin G. Kousoulas

Faculty Publications

The HSV-1 (VC2) live-attenuated vaccine strain was engineered with specific deletions in the amino termini of glycoprotein K (gK) and membrane protein UL20, rendering the virus unable to enter neurons and establish latency. VC2 replicates efficiently in epithelial cell culture but produces lower viral titers and smaller viral plaques than its parental HSV-1 (F) wild-type virus. VC2 is an effective live-attenuated vaccine against HSV-1 and HSV-2 infections in mice and guinea pigs and an anti-tumor immunotherapeutic and oncolytic virus against melanoma and breast cancer in mouse models. Previously, we reported that the gK/UL20 complex interacts with the UL37 tegument protein, …

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Total Utilization-Upcycling Of Mushroom Protein By-Product: Characterization And Assessment As An Alternative Batter Ingredient For Fried Shrimp, Diego Garcia, Seung Woon You, Ricardo S. Aleman, Joan M. King, Slavko Komarnytsky, Roberta Targino Hoskin, Marvin Moncada Feb 2023

Total Utilization-Upcycling Of Mushroom Protein By-Product: Characterization And Assessment As An Alternative Batter Ingredient For Fried Shrimp, Diego Garcia, Seung Woon You, Ricardo S. Aleman, Joan M. King, Slavko Komarnytsky, Roberta Targino Hoskin, Marvin Moncada

Faculty Publications

Mushroom by-products are economical and eco-friendly raw materials with bioactive and functional characteristics that allow for potential uses as food ingredients. However, mushroom upcycling has yet to be fully exploited, despite the many opportunities that mushrooms may offer. The mushroom protein by-product (MPBP) resulting from mushroom protein production was characterized (chemical composition, physicochemical attributes, and functional properties) and incorporated into plant-based batter formulations to prepare four experimental groups with different ratios (w/w, %) of wheat flour (W) to MPBP (100 W, 75 W/25 MPBP, 25 W/75 MPBP, and 100 MPBP). Subsequently, the batter was used for frying batter-coated shrimp, which …

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The Effect Of Watermelon Juice Supplementation On Heart Rate Variability And Metabolic Response During An Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial, Rachel Matthews, Kate S. Early, Cullen M. Vincellette, Jack Losso, Guillaume Spielmann, Brian A. Irving, Timothy D. Allerton Feb 2023

The Effect Of Watermelon Juice Supplementation On Heart Rate Variability And Metabolic Response During An Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial, Rachel Matthews, Kate S. Early, Cullen M. Vincellette, Jack Losso, Guillaume Spielmann, Brian A. Irving, Timothy D. Allerton

Faculty Publications

Heart rate variability (HRV) provides a simple method to evaluate autonomic function in health and disease. A reduction in HRV may indicate autonomic dysfunction and is strongly associated with aspects of cardiometabolic disease, including hyperglycemia. Reduced nitric oxide (NO) bioavailability is also implicated in the development of cardiometabolic disease and autonomic dysfunction. Watermelons are natural sources of L-arginine and L-citrulline, substrates used for NO synthesis. Watermelon consumption can improve NO bioavailability. We conducted a randomized, double-blind, placebo-controlled crossover trial to test the effects of 2 weeks of daily watermelon juice (WMJ) supplementation on HRV in response to an oral glucose …

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Classification Analysis Of Southwest Pacific Tropical Cyclone Intensity Changes Prior To Landfall, Rupsa Bhowmick, Jill C. Trepanier, Alex M. Haberlie Feb 2023

Classification Analysis Of Southwest Pacific Tropical Cyclone Intensity Changes Prior To Landfall, Rupsa Bhowmick, Jill C. Trepanier, Alex M. Haberlie

Faculty Publications

This study evaluates the ability of a random forest classifier to identify tropical cyclone (TC) intensification or weakening prior to landfall over the western region of the Southwest Pacific Ocean (SWPO) basin. For both Australia mainland and SWPO island cases, when a TC first crosses land after spending ≥24 h over the ocean, the closest hour prior to the intersection is considered as the landfall hour. If the maximum wind speed (Vmax) at the landfall hour increased or remained the same from the 24-h mark prior to landfall, the TC is labeled as intensifying and if the Vmax at the …

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Clues From The Paint A Picture Of Earth’S Water Cycle, Kristine L. Delong, Alyssa Atwood, Andrea Moore, Sara Sanchez Feb 2023

Clues From The Paint A Picture Of Earth’S Water Cycle, Kristine L. Delong, Alyssa Atwood, Andrea Moore, Sara Sanchez

Faculty Publications

No abstract provided.

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Editorial Introduction: Contributing To The Policy Process Literatures, Geoboo Song, Michael D. Jones, Melissa K. Merry, Holly L. Peterson, Aaron Smith-Walter, Gwen Arnold, Rachael Moyer, Creed Tumlison Feb 2023

Editorial Introduction: Contributing To The Policy Process Literatures, Geoboo Song, Michael D. Jones, Melissa K. Merry, Holly L. Peterson, Aaron Smith-Walter, Gwen Arnold, Rachael Moyer, Creed Tumlison

Faculty Publications

No abstract provided.

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Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux Feb 2023

Neutron Imaging Of Al6061 Prepared By Solid-State Friction Stir Additive Manufacturing, Saber Nemati, Leslie G. Butler, Kyungmin Ham, Gerald L. Knapp, Congyuan Zeng, Selami Emanet, Hamed Ghadimi, Shengmin Guo, Yuxuan Zhang, Hassina Bilheux

Faculty Publications

Solid-state Friction Stir Additive Manufacturing has recently gained attention as a result of its capacity to fabricate large-scale parts while preserving the mechanical properties of the feedstock material. However, the correlation between the quality of layer-by-layer bonding of the deposited metal and processing parameters has remained unknown. Neutron imaging techniques, with 90% total transmission per cm, are employed for Al6061 parts fabricated by MELD® Technology as a non-destructive evaluation approach for the first time to investigate the layer-by-layer structure of a stadium-shaped ingot in different sections. The post-processed results show the fabricated parts with an optimized set of processing parameters …

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Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo Feb 2023

Hardness Distribution Of Al2050 Parts Fabricated Using Additive Friction Stir Deposition, Hamed Ghadimi, Huan Ding, Selami Emanet, Mojtaba Talachian, Chase Cox, Michael Eller, Shengmin Guo

Faculty Publications

The solid-state additive friction stir deposition (AFSD) process is a layer-by-layer metal 3D-printing technology. In this study, AFSD is used to fabricate Al–Cu–Li 2050 alloy parts. The hardness values for various regions of the as-deposited built parts are measured, and the results are contrasted with those of the feedstock material. The as-fabricated Al2050 parts are found to have a unique hardness distribution due to the location-specific variations in the processing temperature profile. The XRD results indicate the presence of the secondary phases in the deposited parts, and EDS mapping confirms the formation of detectable alloying particles in the as-deposited Al2050 …

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Correction: Design Of Crack-Free Laser Additive Manufactured Inconel 939 Alloy Driven By Computational Thermodynamics Method (Mrs Communications, (2022), 12, 5, (844-849), 10.1557/S43579-022-00253-X), Congyuan Zeng, Huan Ding, Uttam Bhandari, S. M. Guo Feb 2023

Correction: Design Of Crack-Free Laser Additive Manufactured Inconel 939 Alloy Driven By Computational Thermodynamics Method (Mrs Communications, (2022), 12, 5, (844-849), 10.1557/S43579-022-00253-X), Congyuan Zeng, Huan Ding, Uttam Bhandari, S. M. Guo

Faculty Publications

The article Design of crack-free laser additive manufactured Inconel 939 alloy driven by computational thermodynamics method, written by Congyuan Zeng, Huan Ding, Uttam Bhandari, S. M. Guo, was originally published electronically on the publisher’s internet portal on 9 September 2022 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 20 December 2022 to © The Author(s) 2022 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate …

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Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson Feb 2023

Wind Loads On Overhead Sign Structures: A Comparative Study, Aly Mousaad Aly, James Benson

Faculty Publications

Road signs are prone to extreme winds that cause significant damage. Overhead sign structures can disrupt traffic and cause harm to the traveling public if a failure occurs under extreme wind conditions. In this paper, we employ Computational Fluid Dynamics (CFD) in a comparative study to understand the aerodynamics of standard, porous, and curved signs. The study shows the viability of porous and curved overhead boards for lessening aerodynamic loads, which can mini-mize damage and enhance safety on roadways. Porous overhead signs can decrease the drag forces; however, the size of the openings is a vital parameter in reducing wind …

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Vibration Attenuation In A High-Rise Hybrid-Timber Building: A Comparative Study, Suvash Chapain, Aly Mousaad Aly Feb 2023

Vibration Attenuation In A High-Rise Hybrid-Timber Building: A Comparative Study, Suvash Chapain, Aly Mousaad Aly

Faculty Publications

Recent developments in engineered timber products, and their availability, durability, and renewability, have led to taller and more flexible buildings. However, these buildings may experience excessive vibrations, resulting in safety and serviceability issues due to wind or earthquake loads. This paper presents a dynamic analysis of a 42-story-tall hybrid-timber building, along with a comparative study of the performance of three damping devices: (i) pendulum pounding tuned mass damper (PTMD), (ii) tuned mass damper inerter (TMDI), and (iii) tuned mass damper (TMD). First, we evaluate the vibration reduction capability of the TMD and the TMDI under filtered white noise and variable …

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A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe Feb 2023

A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe

Faculty Publications

Microfluidic impedance cytometry has been demonstrated as an effective platform for single cell analysis, taking advantage of microfabricated features and dielectric cell sensing methods. In this study, we present a simple microfluidic device to improve the sensitivity, accuracy, and throughput of single suspension cell viability analysis using vertical sidewall electrodes fabricated by a widely accessible negative manufacturing method. A microchannel milled through a 75 µm platinum wire, which was embedded into poly-methyl-methacrylate (PMMA), created a pair of parallel vertical sidewall platinum electrodes. Jurkat cells were interrogated in a custom low-conductivity buffer (1.2 ± 0.04 mS/cm) to reduce current leakage and …

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Editorial: Emerging Research Organisms In Regenerative Biology, Stefano Tiozzo, Igor Schneider Jan 2023

Editorial: Emerging Research Organisms In Regenerative Biology, Stefano Tiozzo, Igor Schneider

Faculty Publications

No abstract provided.

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Non-Equilibrium Colloidal Phenomena In Magnetic Fields And Photoillumination: From Controlling Living Microbots To Understanding Microplastics, Ahmed Al Harraq Jan 2023

Non-Equilibrium Colloidal Phenomena In Magnetic Fields And Photoillumination: From Controlling Living Microbots To Understanding Microplastics, Ahmed Al Harraq

LSU Doctoral Dissertations

Colloids are a ubiquitous class of materials composed of microscopic particles suspended in a continuous phase which are found in everyday products and in nature. Colloids are also useful models for studying the spontaneous arrangement of matter from individual building blocks to mesophases. Standard treatment of colloid science is based on the assumption of equilibrium conditions, as defined in traditional thermodynamics. However, novel assembly mechanisms and motility are unlocked by pushing colloids away from equilibrium using external energy. In addition, many colloids in nature and in industrial applications exchange energy and mass with the surrounding environment thus behaving in a …

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Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran Jan 2023

Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran

LSU Doctoral Dissertations

This dissertation explores the mechanisms driving sediment transport and deposition on the continental shelf and within the bays of the northern Gulf of Mexico via a suite of geophysical methods and sediment cores on a variety of timescales. This dissertation is comprised of three main chapters, each focusing on a different location, environment, and process but tied together using geophysical survey, a thematic focus on geomorphic change and sediment transport within the deltaic cycle and deltaic plain environments, and the implications this change poses for both past and future sediment transport and environmental change in response to sea level change. …

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Publisher Correction: A Very Luminous Jet From The Disruption Of A Star By A Massive Black Hole (Nature, (2022), 612, 7940, (430-434), 10.1038/S41586-022-05465-8), Igor Andreoni, Michael W. Coughlin, Daniel A. Perley, Yuhan Yao, Wenbin Lu, S. Bradley Cenko, Harsh Kumar, Shreya Anand, Anna Y.Q. Ho, Mansi M. Kasliwal, Antonio De Ugarte Postigo, Ana Sagués-Carracedo, Steve Schulze, D. Alexander Kann, S. R. Kulkarni, Jesper Sollerman, Nial Tanvir, Armin Rest, Luca Izzo, Jean J. Somalwar, David L. Kaplan, Tomás Ahumada, G. C. Anupama, Katie Auchettl, Sudhanshu Barway, Eric C. Bellm, Varun Bhalerao, Joshua S. Bloom, Michael Bremer, Mattia Bulla, Eric Burns, Sergio Campana, Poonam Chandra Jan 2023

Publisher Correction: A Very Luminous Jet From The Disruption Of A Star By A Massive Black Hole (Nature, (2022), 612, 7940, (430-434), 10.1038/S41586-022-05465-8), Igor Andreoni, Michael W. Coughlin, Daniel A. Perley, Yuhan Yao, Wenbin Lu, S. Bradley Cenko, Harsh Kumar, Shreya Anand, Anna Y.Q. Ho, Mansi M. Kasliwal, Antonio De Ugarte Postigo, Ana Sagués-Carracedo, Steve Schulze, D. Alexander Kann, S. R. Kulkarni, Jesper Sollerman, Nial Tanvir, Armin Rest, Luca Izzo, Jean J. Somalwar, David L. Kaplan, Tomás Ahumada, G. C. Anupama, Katie Auchettl, Sudhanshu Barway, Eric C. Bellm, Varun Bhalerao, Joshua S. Bloom, Michael Bremer, Mattia Bulla, Eric Burns, Sergio Campana, Poonam Chandra

Faculty Publications

In the version of this article initially published, there was in an error in the third-to-last sentence of the abstract, now reading, in part, “we calculate a rate of 0.02–0.01 +0.04 Gpc–3 yr–1”, where Gpc was spelled out as gigapascals, not gigaparsecs. Also, the scale label (2″) was missing in the lower-left corner of Fig. 1b. The errors have been corrected in the HTML and PDF versions of the article.

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An Exploration Of Black Women Faculty Members' Faculty Development And Career Advancement Experiences Within A Pwi, Monica N. Guient Jan 2023

An Exploration Of Black Women Faculty Members' Faculty Development And Career Advancement Experiences Within A Pwi, Monica N. Guient

LSU Doctoral Dissertations

At a large, research-intensive, predominantly White university, in this qualitative case study, Black women faculty members’ experiences with and perceptions of institutionally sponsored faculty development activities in relation to career advancement was explored. The career advancement of faculty members from underrepresented and minoritized populations—particularly Black women—is ultimately impacted by the racialized and gendered disparities among tenure-track and tenured professors in research, service, and teaching. Unique to this study is the exploration of how Black women faculty members experience the human resource development practice of faculty development while also gathering information from the institutional leaders who oversee and guide institutionally sponsored …

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Contact-Type Endoscope Sers Probe, And Related Methods, Martin Feldman, Dooyoung Hah Jan 2023

Contact-Type Endoscope Sers Probe, And Related Methods, Martin Feldman, Dooyoung Hah

College of Engineering Patents

A contact-type endoscope surface enhanced Raman scattering (SERS) probe includes a gradient-index (GRIN) lens, a transparent substrate adhered to the GRIN lens, and a rough metallic layer adhered to an opposite side of the transparent substrate from the GRIN lens. The GRIN lens focuses light from a Raman spectrometer onto the rough metallic layer, and the rough metallic layer is positioned at the distal end of the contact-type endoscope SERS probe.

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Contact-Type Endoscope Sers Probe, And Related Methods, Martin Feldman, Dooyoung Hah Jan 2023

Contact-Type Endoscope Sers Probe, And Related Methods, Martin Feldman, Dooyoung Hah

College of Engineering Patents

A contact-type endoscope surface enhanced Raman scattering (SERS) probe includes a gradient-index (GRIN) lens, a transparent substrate adhered to the GRIN lens, and a rough metallic layer adhered to an opposite side of the transparent substrate from the GRIN lens. The GRIN lens focuses light from a Raman spectrometer onto the rough metallic layer, and the rough metallic layer is positioned at the distal end of the contact-type endoscope SERS probe.

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Investigating The Potential Role Of Termites As Pathogen Vectors In The Decline Of Ironwood Trees (Casuarina Equisetifolia) In Guam, Garima Setia Jan 2023

Investigating The Potential Role Of Termites As Pathogen Vectors In The Decline Of Ironwood Trees (Casuarina Equisetifolia) In Guam, Garima Setia

LSU Master's Theses

Termites have been found associated with the decline of Casuarina equisetifolia (ironwood), an important agro-forestry species in Guam. While the ironwood tree decline (IWTD) was first reported in 2002, its association with termites as well as with bacteria Ralstonia solanacearum and Klebsiella species (K. oxytoca and K. variicola) was determined in 2010 and 2012 respectively. In 2019, the termite species attacking the ironwood trees were identified as Nasutitermes takasagoensis, Coptotermes gestroi, and Microcerotermes crassus. However, the role of termites in IWTD is not known. Since termites are repositories of bacteria and consume wood, termite foragers might …

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Integrated Ion-Exchange Membrane Resin Wafer Assemblies For Aromatic Organic Acid Separations Using Electrodeionization, Matthew L. Jordan, Grzegorz Kokoszka, Hishara Keshani Gallage Dona, Dodangodage Ishara Senadheera, Revati Kumar, Yupo J. Lin, Christopher G. Arges Jan 2023

Integrated Ion-Exchange Membrane Resin Wafer Assemblies For Aromatic Organic Acid Separations Using Electrodeionization, Matthew L. Jordan, Grzegorz Kokoszka, Hishara Keshani Gallage Dona, Dodangodage Ishara Senadheera, Revati Kumar, Yupo J. Lin, Christopher G. Arges

Faculty Publications

Aromatic acids, such as p-coumaric acid, are valuable chemical intermediates that are used in the specialty chemical industries because they are precursors to phenylpropanoid compounds. The separation of p-coumaric acid from fermentation broths is a critical step in the biochemical production process and more broadly the circular carbon economy. Electrodeionization (EDI) has been applied toward separations of low-carbon chain acids, but purifying p-coumaric acid has been challenging due to fouling and irreversible binding with ion-exchange membranes and resins. Here, we report a new membrane wafer assembly (MWA) consisting of laminated ion exchange membranes to porous ionomer-binder resin wafers for EDI. …

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Effect Od Different Sources And Application Rates Of Sulfur On Corn And Soybean Production Systems In Louisiana, Diego Mayorga Valladares Jan 2023

Effect Od Different Sources And Application Rates Of Sulfur On Corn And Soybean Production Systems In Louisiana, Diego Mayorga Valladares

LSU Master's Theses

Sulfur (S) is a structural component of amino acids such as cysteine and methionine and is involved in important functions within the plant like photosynthesis, carbon and nitrogen metabolism, protein synthesis of oils, and detoxification mechanisms. Sulfur deficiency in crops has intensified around the world. Some of the reasons are improvement in controlling SO2 emissions from industries, growing usage of high analysis S-free fertilizers and augmented cropping intensity. Sulfur fertilization has become an important factor in crop production systems and fertilization guidelines for S need to be up-to-date to improve use efficiency and compensate for rising prices of fertilizers. …

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The Impacts Of Immune Challenges On Fish Behavior And Physiology, Teisha King Jan 2023

The Impacts Of Immune Challenges On Fish Behavior And Physiology, Teisha King

LSU Doctoral Dissertations

For species living in dominance hierarchies, social rank dictates access to resources and often contributes to reproductive success. To ensure survival, individuals constantly evaluate trade- offs between crucial biological systems, like the reproductive and immune systems, depending on their social rank and physiological state. Little is known about how social species balance interactions between immune system function, fluctuations in social status and reproductive fitness, and the performance of behaviors necessary for maintaining social status when sick, particularly in fishes, the largest and most diverse group of vertebrates. My dissertation research uses a whole animal approach to examine how physiological profiles …

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First-Principles Molecular Dynamics Study Of Liquid Iron-Rich Alloys Under Conditions Of The Earth’S Core, Dipendra Banjara Jan 2023

First-Principles Molecular Dynamics Study Of Liquid Iron-Rich Alloys Under Conditions Of The Earth’S Core, Dipendra Banjara

LSU Doctoral Dissertations

In this dissertation, we report the results of the first-principles molecular dynamics (FPMD) simulations and data analysis on the thermodynamic, structural, and transport properties of iron-rich metallic liquids considering several light and heavy elements under wide ranges of pressure and temperature that are relevant to the earth’s core. Our simulations of pure liquid iron cover the pressure range from 0 GPa at 2000 K to 380 GPa at 7000 K perhaps representing the most extensive computational study to date. We studied four molten iron-rich alloys corresponding to 2.67 atom% of Ni, Co, Mo, and W at pressures up to 380 …

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Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond Jan 2023

Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond

LSU Master's Theses

Estuaries within the Gulf of Mexico are exhibiting profound alterations due to climatic changes and the implementation of coastal restoration activities. These changes are attributed to the increasing frequency of harmful cyanobacteria blooms (cyanoHABs) within Lake Pontchartrain, an estuary located in southeastern Louisiana, USA. There is a better understanding into how the opening of the Bonnet Carré Spillway (BCS) impacts cyanoHAB formations compared to the effect of other physical drivers when the spillway doesn’t dominate the system. The goal of this study is to provide a greater understanding of the baseline conditions when the BCS is closed and determine what …

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Chiral Uncertainties In Ab Initio Elastic Nucleon-Nucleus Scattering, Robert B. Baker, Matthew Burrows, Charlotte Elster, Kristina D. Launey, Pieter Maris, Gabriela Popa, Stephen P. Weppner Jan 2023

Chiral Uncertainties In Ab Initio Elastic Nucleon-Nucleus Scattering, Robert B. Baker, Matthew Burrows, Charlotte Elster, Kristina D. Launey, Pieter Maris, Gabriela Popa, Stephen P. Weppner

Faculty Publications

The effective interaction between a nucleon and a nucleus is one of the most important ingredients for reaction theories. Theoretical formulations were introduced early by Feshbach and Watson, and efforts of deriving and computing those ‘optical potentials’ in a microscopic fashion have a long tradition. However, only recently the leading order term in the Watson multiple scattering approach could be calculated fully ab initio, meaning that the same nucleon-nucleon (NN) interaction enters both the structure as well as the reaction pieces on equal footing. This allows the uncertainties from the underlying chiral effective NN interaction to be systematically explored in …

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Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel Jan 2023

Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel

LSU Doctoral Dissertations

The ubiquitin-proteasome system (UPS) is a biochemical pathway primarily responsible for the degradation of damaged proteins. The UPS is regulated by E3 ubiquitin ligases, which recognize specific degradation sequences, or degrons, on a protein leading to protein ubiquitination and subsequent degradation by the proteasome. Proteolysis targeting chimeras (PROTACs) have emerged as a novel therapeutic agent to selectively degrade ‘undruggable’ targets; however, many peptide-based PROTACs suffer low cell permeability and high protease susceptibility. The goal of this work is to utilize degron-based substrates that function as cell penetrating peptides (CPPs) in a PROTAC to selectively degrade a target. The first part …

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