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Linkage Disequilibrium And Haplotype Diversity In The Genes Of The Renin-Angiotensin System: Findings From The Family Blood Pressure Program, Xiaofeng Zhu, Denise Yan, Richard S. Cooper, Amy Luke, Morna A. Ikeda, Yen Pei C. Chang, Alan Weder, Aravinda Chakravarti Feb 2003

Linkage Disequilibrium And Haplotype Diversity In The Genes Of The Renin-Angiotensin System: Findings From The Family Blood Pressure Program, Xiaofeng Zhu, Denise Yan, Richard S. Cooper, Amy Luke, Morna A. Ikeda, Yen Pei C. Chang, Alan Weder, Aravinda Chakravarti

Faculty Publications

Association studies of candidate genes with complex traits have generally used one or a few single nucleotide polymorphisms (SNPs), although variation in the extent of linkage disequilibrium (LD) within genes markedly influences the sensitivity and precision of association studies. The extent of LD and the underlying haplotype structure for most candidate genes are still unavailable. We sampled 193 blacks (African-Americans) and 160 whites (European-Americans) and estimated the intragenic LD and the haplotype structure in four genes of the renin-angiotensin system. We genotyped 25 SNPs, with all but one of the pairs spaced between 1 and 20 kb, thus providing resolution …

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The Regulation And Activation Of Ciliary Neurotrophic Factor Signaling Proteins In Adipocytes, Sanjin Zvonic, Peter Cornelius, William C. Stewart, Randall L. Mynatt, Jacqueline M. Stephens Jan 2003

The Regulation And Activation Of Ciliary Neurotrophic Factor Signaling Proteins In Adipocytes, Sanjin Zvonic, Peter Cornelius, William C. Stewart, Randall L. Mynatt, Jacqueline M. Stephens

Faculty Publications

Ciliary neurotrophic factor (CNTF) is primarily known for its roles as a lesion factor released by the ruptured glial cells that prevent neuronal degeneration. However, CNTF has also been shown to cause weight loss in a variety of rodent models of obesity/type II diabetes, whereas a modified form also causes weight loss in humans. CNTF administration can correct or improve hyperinsulinemia, hyperphagia, and hyperlipidemia associated with these models of obesity. In order to investigate the effects of CNTF on fat cells, we examined the expression of CNTF receptor complex proteins (LIFR, gp130, and CNTFRα) during adipocyte differentiation and the effects …

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The System Parameters Of Dw Ursae Majoris, S. Araujo-Betancor, C. Knigge, K. S. Long, D. W. Hoard, P. Szkody, B. Rodgers, K. Krisciunas, V. S. Dhillon, R. I. Hynes, J. Patterson, J. Kemp Jan 2003

The System Parameters Of Dw Ursae Majoris, S. Araujo-Betancor, C. Knigge, K. S. Long, D. W. Hoard, P. Szkody, B. Rodgers, K. Krisciunas, V. S. Dhillon, R. I. Hynes, J. Patterson, J. Kemp

Faculty Publications

We present new constraints on the system parameters of the SW Sextantis star DW Ursae Majoris, based on ultraviolet (UV) eclipse observations with the Hubble Space Telescope. Our data were obtained during a low state of the system, in which the UV light was dominated by the hot white dwarf (WD) primary. The duration of the WD eclipse allows us to set a firm lower limit on the mass ratio, q = M2/M1 > 0.24; if q < 1.5 (as expected on theoretical grounds) the inclination must satisfy i > 71°. We have also been able to determine the duration of WD ingress and egress from our data. This allows us to constrain the …

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Local And Global Properties Of Conformal Initial Data For Black-Hole Collisions, Nina Jansen, Peter Diener, Jakob Hensen, Alexei Khokhlov, Igor Novikov Jan 2003

Local And Global Properties Of Conformal Initial Data For Black-Hole Collisions, Nina Jansen, Peter Diener, Jakob Hensen, Alexei Khokhlov, Igor Novikov

Faculty Publications

We study the physical properties of conformally flat initial data for single and binary black-hole configurations obtained using imaging and puncture methods. We investigate how the total mass Mtot of a dataset with two black holes depends on the configuration of linear or angular momentum and separation of the holes. The asymptotic behaviour of Mtot with increasing separation allows us to make conclusions about a nonphysical extra gravitational field introduced in the solutions by the conformally flat approach. We also calculate the spatial distribution of scalar invariants of the Riemann tensor which determine the gravitational tidal forces. For single black-hole …

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Formation And Character Of An Ancient 19-M Ice Cover And Underlying Trapped Brine In An "Ice-Sealed" East Antarctic Lake, Peter T. Doran, Christian H. Fritsen, Christopher P. Mckay, John C. Priscu, Edward E. Adams Jan 2003

Formation And Character Of An Ancient 19-M Ice Cover And Underlying Trapped Brine In An "Ice-Sealed" East Antarctic Lake, Peter T. Doran, Christian H. Fritsen, Christopher P. Mckay, John C. Priscu, Edward E. Adams

Faculty Publications

Lake Vida, one of the largest lakes in the McMurdo Dry Valleys of Antarctica, was previously believed to be shallow (<10 >m) and frozen to its bed year-round. New ice-core analysis and temperature data show that beneath 19 m of ice is a water column composed of a NaCl brine with a salinity seven times that of seawater that remains liquid below - 10°C. The ice cover thickens at both its base and surface, sealing concentrated brine beneath. The ice cover is stabilized by a negative feedback between ice growth and the freezing-point depression of the brine. The ice cover …

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Tissue-Specific Structure/Function Differentiation Of The Liver Isoform Of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase, Yong Hwan Lee, Yang Li, Kosaku Uyeda, Charles A. Hasemann Jan 2003

Tissue-Specific Structure/Function Differentiation Of The Liver Isoform Of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase, Yong Hwan Lee, Yang Li, Kosaku Uyeda, Charles A. Hasemann

Faculty Publications

The crystal structures of the human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in three different liganding states were determined and compared with those of the rat testis isozyme. A set of amino acid sequence heterogeneity from the two distinct genes encoding the two different tissue isozymes leads to both global and local conformational differences that may cause the differences in catalytic properties of the two isozymes. The sequence differences in a β-hairpin loop in the kinase domain causes a translational shift of several hydrophobic interactions in the dimeric contact region, and its propagation to the domains interface results in a 5° twist of the …

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Microscopic Description Of The Scissors Mode In Odd-Mass Heavy Deformed Nuclei, Carlos E. Vargas, Jorge G. Hirsch, Jerry P. Draayer Jan 2003

Microscopic Description Of The Scissors Mode In Odd-Mass Heavy Deformed Nuclei, Carlos E. Vargas, Jorge G. Hirsch, Jerry P. Draayer

Faculty Publications

Pseudo-SU(3) shell-model results are reported for M1 excitation strengths in 157Gd, 163Dy and 169Tm in the energy range between 2 and 4 MeV. Non-zero pseudo-spin couplings between the configurations play a very important role in determining the M1 strength distribution, especially its rapidly changing fragmentation pattern which differs significantly from what has been found in neighboring even-even systems. The results suggest one should examine contributions from intruder levels. ©2002 Elsevier Science B.V. All rights reserved.

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Linking Landscape And Water Quality In The Mississippi River Basin For 200 Years, R. Eugene Turner, Nancy N. Rabalais Jan 2003

Linking Landscape And Water Quality In The Mississippi River Basin For 200 Years, R. Eugene Turner, Nancy N. Rabalais

Faculty Publications

Two centuries of land use in the Mississippi River watershed are reflected in the water quality of its streams and in the continental shelf ecosystem receiving its discharge. The most recent influence on nutrient loading-intense and widespread farming and especially fertilizer use-has had a more significant effect on water quality than has land drainage or the conversion of native vegetation to cropland and grazing pastures. The 200-year record of nutrient loading to offshore water is reflected in the paleoreconstructed record of plankton in dated sediments. This record illustrates that the development of fair, sustained management of inland ecosystems is linked …

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Predicting The Response Of Gulf Of Mexico Hypoxia To Variations In Mississippi River Nitrogen Load, D Scavia, N N. Rabalais, R. Eugene Turner, D Justic, D Scavia Jan 2003

Predicting The Response Of Gulf Of Mexico Hypoxia To Variations In Mississippi River Nitrogen Load, D Scavia, N N. Rabalais, R. Eugene Turner, D Justic, D Scavia

Faculty Publications

The effects of nutrient loading from the Mississippi River basin on the areal extent of hypoxia in the northern Gulf of Mexico were examined using a novel application of a dissolved oxygen model for a river. The model, driven by river nitrogen load and a simple parameterization of ocean dynamics, reproduced 17 yr of observed hypoxia location and extent, subpycnocline oxygen consumption, and cross-pycnocline oxygen flux. With Monte Carlo analysis, we illustrate through hindcasts back to 1968 that extensive regions of low oxygen were not common before the mid-1970s. The Mississippi River Watershed/Gulf of Mexico Hypoxia Task Force set a …

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Review Of In The Shadows Of War :An American Pilot's Odyssey Through Occupied France And The Camps Of Nazi Germany, Michael F. Russo Jan 2003

Review Of In The Shadows Of War :An American Pilot's Odyssey Through Occupied France And The Camps Of Nazi Germany, Michael F. Russo

Faculty Publications

No abstract provided.

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Gumbo Yearbook, Class Of 2003, Louisiana State University And Agricultural And Mechanical College Jan 2003

Gumbo Yearbook, Class Of 2003, Louisiana State University And Agricultural And Mechanical College

Gumbo Yearbook

The Gumbo yearbook chronicles the entire academic year at LSU. In words and especially photos, the Gumbo shows the people, places, and events that make each year unique. In addition to formal portraits of schools and departments, the book contains hundreds of snapshots of students with their friends and dozens of pages showcasing organizations.

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Lsu General Catalog 2003-2004, Louisiana State University And Agricultural And Mechanical College Jan 2003

Lsu General Catalog 2003-2004, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The General Catalog includes information on registration and financial aid as well as academic services offered to all students.

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Matrix Heterogeneity And Host-Parasitoid Interactions In Space, James T. Cronin Jan 2003

Matrix Heterogeneity And Host-Parasitoid Interactions In Space, James T. Cronin

Faculty Publications

In this study, I experimentally examined how the landscape matrix influenced the movement, oviposition behavior, and spatial distribution of Anagrus columbi, a common egg parasitoid of the planthopper Prokelisia crocea. Both species exist among discrete patches of prairie cordgrass (Spartina pectinata), the sole host plant of P. crocea. Based on out-planted cordgrass pots bearing host eggs (to assess parasitism) or sticky leaves (traps for adult A. columbi), I found that the distribution of adult female A. columbi and pattern of ovipositions within a cordgrass patch were strongly matrix dependent. Female densities were 59% lower on the edge than interior of …

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Matrix Composition Affects The Spatial Ecology Of A Prairie Planthopper, Kyle J. Haynes, James T. Cronin Jan 2003

Matrix Composition Affects The Spatial Ecology Of A Prairie Planthopper, Kyle J. Haynes, James T. Cronin

Faculty Publications

To date, there is a lack of well-controlled field experiments that disentangle the effects of the intervening matrix from other landscape variables (e.g., patch geography or quality) that might influence animal dispersal among patches. We performed a field experiment to investigate how the movement of a delphacid planthopper (Prokelisia crocea) among discrete patches of prairie cordgrass (Spartina pectinata) is affected by the composition of the matrix (mudflat, native nonhost grasses, and the introduced grass smooth brome [Bromus inermis]). Within each matrix type, marked planthoppers were released onto experimental cordgrass patches that were made identical in size, isolation, and host plant …

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Children's Sociable And Aggressive Behaviour With Peers: A Comparison Of The Us And Australia, And Contributions Of Temperament And Parenting Styles, Alan Russell, Craig H. Hart, Clyde C. Robinson, Susanne F. Olsen Jan 2003

Children's Sociable And Aggressive Behaviour With Peers: A Comparison Of The Us And Australia, And Contributions Of Temperament And Parenting Styles, Alan Russell, Craig H. Hart, Clyde C. Robinson, Susanne F. Olsen

Faculty Publications

Links between both temperament and parenting, and children's sociable and aggressive behaviour with peers (physical and relational), were examined. The research was undertaken in two Western cultures (the United States and Australia) assumed to be similar in socialisation practices and emphases. The moderating effects of parent sex and child sex were also examined. Parents completed questionnaires on parenting styles and child temperament. Preschool teachers rated children's aggressive and sociable behaviour. US children were rated higher on both types of aggression by teachers and on sociability, activity, and emotionality by parents. Girls were rated as more relationally aggressive and more prosocial …

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Two Rna Binding Proteins, Hen4 And Hua1 Act In The Processing Of Agamous Pre-Mrna In Arabidopsis Thaliana, Yulan Cheng, Naohiro Kato, Wenming Wang, Junjie Li, Xuemei Chen Jan 2003

Two Rna Binding Proteins, Hen4 And Hua1 Act In The Processing Of Agamous Pre-Mrna In Arabidopsis Thaliana, Yulan Cheng, Naohiro Kato, Wenming Wang, Junjie Li, Xuemei Chen

Faculty Publications

AGAMOUS, a key player in floral morphogenesis, specifies reproductive organ identities and regulates the timely termination of stem cell fates in the floral meristem. Here, we report that strains carrying mutations in three genes, HUA1, HUA2, and HUA ENHANCER4 (HEN4), exhibit floral defects similar to those in agamous mutants: reproductive-to-perianth organ transformation and loss of floral determinacy. HEN4 codes for a K homology (KH) domain-containing, putative RNA binding protein that interacts with HUA1, a CCCH zinc finger RNA binding protein in the nucleus. We show that HUA1 binds AGAMOUS pre-mRNA in vitro and that HEN4, HUA1, and HUA2 act in …

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Influence Of The El Niño Southern Oscillation On Fire Regimes In The Florida Everglades, Brian Beckage, William J. Platt, Matthew G. Slocum, Bob Panko Jan 2003

Influence Of The El Niño Southern Oscillation On Fire Regimes In The Florida Everglades, Brian Beckage, William J. Platt, Matthew G. Slocum, Bob Panko

Faculty Publications

Disturbances that are strongly linked to global climatic cycles may occur in a regular, predictable manner that affects composition and distribution of ecological communities. The El Niño Southern Oscillation (ENSO) influences worldwide precipitation patterns and has occurred with regular periodicity over the last 130 000 years. We hypothesized that ENSO, through effects on local weather conditions, has influenced frequency and extent of fires within Everglades National Park (Florida, USA). Using data from 1948 to 1999, we found that the La Nina phase of ENSO was associated with decreased dry-season rainfall, lowered surface water levels, increased lightning strikes, more fires, and …

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William E. Doolittle: Mediator Between The World Of Work And The World Of Books, Andrew Sluyter Jan 2003

William E. Doolittle: Mediator Between The World Of Work And The World Of Books, Andrew Sluyter

Faculty Publications

No abstract provided.

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Neo-Environmental Determinism, Intellectual Damage Control, And Nature/Society Science, Andrew Sluyter Jan 2003

Neo-Environmental Determinism, Intellectual Damage Control, And Nature/Society Science, Andrew Sluyter

Faculty Publications

No abstract provided.

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Material-Conceptual Landscape Transformation And The Emergence Of The Pristine Myth In Early Colonial Mexico, Andrew Sluyter Jan 2003

Material-Conceptual Landscape Transformation And The Emergence Of The Pristine Myth In Early Colonial Mexico, Andrew Sluyter

Faculty Publications

No abstract provided.

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Use Of Common Weeds Of Rice As Hosts For The Rice Water Weevil (Coleoptera: Curculionidae), K. V. Tindall, M. J. Stout Jan 2003

Use Of Common Weeds Of Rice As Hosts For The Rice Water Weevil (Coleoptera: Curculionidae), K. V. Tindall, M. J. Stout

Faculty Publications

The rice water weevil, Lissorhoptrus oryzophilus Kuschel, is the most important insect pest in rice, Oryza sativa L., in the United States, Prior research indicates that rice water weevils feed primarily on monocotyledonous plants. Many monocot weeds occur in rice fields, but little is known about rice water weevil-weed interactions in rice. Host utilization of the rice water weevil was evaluated on rice, cultivar 'Cocodrie', and seven weeds commonly found in rice fields in preference and life cycle compatibility tests in the greenhouse. Barnyardgrass, Echinochloa crus-galli Beauv., yellow nutsedge, Cyperus esculentus L., broadleaf signalgrass, Brachiaria platyphylla Nash., and fall panicum, …

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Plasma Membrane Topology Of Syncytial Domains Of Herpes Simplex Virus Type 1 Glycoprotein K (Gk): The Ul20 Protein Enables Cell Surface Localization Of Gk But Not Gk-Mediated Cell-To-Cell Fusion, Timothy P. Foster, Xavier Alvarez, Konstantin G. Kousoulas Jan 2003

Plasma Membrane Topology Of Syncytial Domains Of Herpes Simplex Virus Type 1 Glycoprotein K (Gk): The Ul20 Protein Enables Cell Surface Localization Of Gk But Not Gk-Mediated Cell-To-Cell Fusion, Timothy P. Foster, Xavier Alvarez, Konstantin G. Kousoulas

Faculty Publications

Most spontaneously occurring mutations that cause extensive herpes simplex virus type 1 (HSV-1)-induced cell fusion are single amino acid changes within glycoprotein K (gK). Despite the strong genetic association of gK with virus-induced cell fusion, its direct involvement in cellular membrane fusion has been controversial, largely due to previously unsuccessful efforts to detect gK expression on virion and cellular surfaces. Recently, we showed that gK is expressed on HSV-1 virions and functioned in virus entry (T. P. Foster, G. V. Rybachuk, and K. G. Kousoulas, J. Virol. 75:12431-12438, 2001). To determine whether gK is expressed on cellular surfaces, as well …

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Natural Bovine Lentiviral Type 1 Infection In Holstein Dairy Cattle. I. Clinical, Serological, And Pathological Observations, T. G. Snider, B. F. Jenny, P. G. Hoyt, K. S. Coats, K. F. Graves, C. R. Cooper, R. W. Storts, D. G. Luther Jan 2003

Natural Bovine Lentiviral Type 1 Infection In Holstein Dairy Cattle. I. Clinical, Serological, And Pathological Observations, T. G. Snider, B. F. Jenny, P. G. Hoyt, K. S. Coats, K. F. Graves, C. R. Cooper, R. W. Storts, D. G. Luther

Faculty Publications

Clinical, serological, and pathological abnormalities observed in Holstein cows naturally infected with bovine lentivirus 1 bovine immunodeficiency virus (BIV) and other infections were progressive and most commonly associated with weight loss, lymphoid system deficiency, and behavioral changes. Clinical evidence of meningoencephalitis was dullness, stupor, and occasional head or nose pressing postures. The polymerase chain reactions associated the BIV provirus with the lesions in the central nervous system and lymphoid tissues. Multiple concurrent infections developed in retrovirally infected cows undergoing normal stresses associated with parturition and lactation. A major functional correlate of the lymphoreticular alterations was the development of multiple secondary …

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Growth Performance Of Different Breed Crosses Of Chicks Fed Diets With Different Protein And Energy Sources, J. L. Shelton, I. Mavromichalis, R. L. Payne, L. L. Southern, D. H. Baker Jan 2003

Growth Performance Of Different Breed Crosses Of Chicks Fed Diets With Different Protein And Energy Sources, J. L. Shelton, I. Mavromichalis, R. L. Payne, L. L. Southern, D. H. Baker

Faculty Publications

Six experiments (EXP) were conducted to evaluate growth performance of different breed crosses of broiler chicks fed diets containing soybean meal, soy protein isolate (SPI), soy protein concentrate (SPC), or rice and casein. Cornish x Plymouth Rock (CxPR; EXP 1, 3, 4, 5, and 6) or New Hampshire x Columbian (NHxC; EXP 2 and 4) cross chicks were used. The chicks were fed a corn-soybean meal (C-SBM) diet before allotment to treatment. The age of the chicks ranged from 5 to 9 d posthatching at the start of the EXP, and the assay periods ranged from 8 to 14 d. …

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Mobile Element-Based Assay For Human Gender Determination, Dale J. Hedges, Jerilyn A. Walker, Pauline A. Callinan, Jaiprakash G. Shewale, Sudhir K. Sinha, Mark A. Batzer Jan 2003

Mobile Element-Based Assay For Human Gender Determination, Dale J. Hedges, Jerilyn A. Walker, Pauline A. Callinan, Jaiprakash G. Shewale, Sudhir K. Sinha, Mark A. Batzer

Faculty Publications

No abstract provided.

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Allelic Heterogeneity In Line-1 Retrotransposition Activity, Sheila M. Lutz, Bethaney J. Vincent, Haig H. Kazazian, Mark A. Batzer, John V. Moran Jan 2003

Allelic Heterogeneity In Line-1 Retrotransposition Activity, Sheila M. Lutz, Bethaney J. Vincent, Haig H. Kazazian, Mark A. Batzer, John V. Moran

Faculty Publications

De novo LINE-1 (long interspersed element-1, or L1) retrotransposition events are responsible for ∼1/1,000 disease-causing mutations in humans. Previously, L1.2 was identified as the likely progenitor of a mutagenic insertion in the factor VIII gene in a patient with hemophilia A. It subsequently was shown to be one of a small number of active L1s in the human genome. Here, we demonstrate that L1.2 is present at an intermediate insertion allele frequency in worldwide human populations and that common alleles (L1.2A and L1.2B) exhibit an ∼16-fold difference in their ability to retrotranspose in cultured human HeLa cells. Chimera analysis revealed …

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Haplotypes In The Dystrophin Dna Segment Point To A Mosaic Origin Of Modern Human Diversity, Ewa Ziȩtkiewicz, Vania Yotova, Dominik Gehl, Tina Wambach, Isabel Arrieta, Mark Batzer, David E.C. Cole, Peter Hechtman, Feige Kaplan, David Modiano, Jean Paul Moisan, Roman Michalski, Damian Labuda Jan 2003

Haplotypes In The Dystrophin Dna Segment Point To A Mosaic Origin Of Modern Human Diversity, Ewa Ziȩtkiewicz, Vania Yotova, Dominik Gehl, Tina Wambach, Isabel Arrieta, Mark Batzer, David E.C. Cole, Peter Hechtman, Feige Kaplan, David Modiano, Jean Paul Moisan, Roman Michalski, Damian Labuda

Faculty Publications

Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigated 35 simple polymorphic sites and one Tn microsatellite in an 8-kb segment of the dystrophin gene. We found 86 haplotypes in 1,343 chromosomes from around the world. Although a classical out-of-Africa topology was observed in trees based on the variant frequencies, the tree of haplotype sequences reveals three lineages accounting for present-day diversity. The proportion of new recombinants and the diversity of the Tn microsatellite were used to estimate the age …

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Effect Of Horn Fly (Haematobia Irritans) Control On Growth And Reproduction Of Beef Heifers, S. M. Derouen, L. D. Foil, A. J. Mackay, D. E. Franke, D. W. Sanson, W. E. Wyatt Jan 2003

Effect Of Horn Fly (Haematobia Irritans) Control On Growth And Reproduction Of Beef Heifers, S. M. Derouen, L. D. Foil, A. J. Mackay, D. E. Franke, D. W. Sanson, W. E. Wyatt

Faculty Publications

The influence of horn fly control with commercially available ear tags was studied on beef replacement heifers (n = 670) for growth and reproductive performance. The study was conducted at five sites in Louisiana over 3 yr. Heifers used were yearling replacement females that were exposed to fertile bulls during a limited spring breeding season that coincided with the horn fly season. In mid to late May of each year, heifers were randomly assigned to one of two horn fly treatments: untreated and treated for horn fly control. The trial continued each year until September or October at the end …

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Coloring Graphs With Crossings, Wei Zhao Jan 2003

Coloring Graphs With Crossings, Wei Zhao

Honors Capstones

No abstract provided.

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Louisiana Agriculture Winter, 2003, Lsu Agcenter Jan 2003

Louisiana Agriculture Winter, 2003, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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