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Environmentally Persistent Free Radicals: Insights On A New Class Of Pollutants, Eric P. Vejerano, Guiying Rao, Lavrent Khachatryan, Stephania A. Cormier, Slawo Lomnicki Mar 2018

Environmentally Persistent Free Radicals: Insights On A New Class Of Pollutants, Eric P. Vejerano, Guiying Rao, Lavrent Khachatryan, Stephania A. Cormier, Slawo Lomnicki

Faculty Publications

© 2018 American Chemical Society. Environmentally persistent free radicals, EPFRs, exist in significant concentration in atmospheric particulate matter (PM). EPFRs are primarily emitted from combustion and thermal processing of organic materials, in which the organic combustion byproducts interact with transition metal-containing particles to form a free radical-particle pollutant. While the existence of persistent free radicals in combustion has been known for over half-a-century, only recently that their presence in environmental matrices and health effects have started significant research, but still in its infancy. Most of the experimental studies conducted to understand the origin and nature of EPFRs have focused primarily …

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Jak/Stat3 Regulated Global Gene Expression Dynamics During Late-Stage Reprogramming Process, Ling Wang, Zongliang Jiang, Delun Huang, Jingyue Duan, Chang Huang, Shannon Sullivan, Kaneha Vali, Yexuan Yin, Ming Zhang, Jill Wegrzyn, Xiuchun Cindy Tian, Young Tang Mar 2018

Jak/Stat3 Regulated Global Gene Expression Dynamics During Late-Stage Reprogramming Process, Ling Wang, Zongliang Jiang, Delun Huang, Jingyue Duan, Chang Huang, Shannon Sullivan, Kaneha Vali, Yexuan Yin, Ming Zhang, Jill Wegrzyn, Xiuchun Cindy Tian, Young Tang

Faculty Publications

© 2018 The Author(s). Background: The generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF) activated Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway is the master regulator for naïve-state pluripotency achievement and maintenance. However, the regulatory process to attain naïve pluripotent iPSCs is not well understood. Results: We performed transcriptome analysis to dissect the genomic expression during mouse iPSC induction, with or without blocking the JAK/STAT3 activity. We describe JAK/STAT3 signaling-specific biological events such as gametogenesis, meiotic/mitotic cell cycle, and DNA repair, and JAK/STAT3-dependent expression of key transcription factors such …

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The Status Of Safety Culture At Louisiana State University, Jerry Edward Steward Mar 2018

The Status Of Safety Culture At Louisiana State University, Jerry Edward Steward

LSU Doctoral Dissertations

This work accesses the nature of and level of safety culture in the academic research community at Louisiana State University and Agricultural and Mechanical College (LSU). After serious chemical related accidents in academic research laboratories the National Academies of Science has made recommendations to improve safety within academic research by encouraging researchers to go beyond simple compliance with regulations and work toward fostering a strong, positive safety culture. The term, “safety culture” is used to describe workplace safety in various efforts to improve it. Researchers have studied these concepts from technical, social, and psychological viewpoints leading to the general consensus …

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Reasonable Exceptions: Supreme Court Rhetoric And The Right To Privacy, Lindsay Susan Head Mar 2018

Reasonable Exceptions: Supreme Court Rhetoric And The Right To Privacy, Lindsay Susan Head

LSU Doctoral Dissertations

Reasonable Exceptions excavates and elaborates the rhetorical, contextual, and ideological underpinnings of the right to privacy. Originating in writing, as a single sentence drafted in 1791, the Fourth Amendment has been one of the most adaptable and unstable concepts in American culture. This project explores the fluctuating ways in which Americans have understood the rights it confers and connects to the ethics of rhetoric and writing practices in a variety of ways. It focus on three seminal Supreme Court opinions, examining their use of precedent and their strategic engagement with contemporaneous technological, social, and political changes: Katz v. United States …

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Legacy Contaminants In The Northern Gulf Of Mexico Shelf, Jessica N. Landry Mar 2018

Legacy Contaminants In The Northern Gulf Of Mexico Shelf, Jessica N. Landry

LSU Master's Theses

The Mississippi River watershed is the third largest in the world and drains from 31 states in the United States. Due to its route through the U.S., it passes through hundreds of EPA labeled Superfund sites as well as agricultural and suburban watersheds. These sites are known to have historical chemical contamination, and as a result chemicals can be transported by runoff down the Mississippi River into the Gulf of Mexico where their ultimate fate is unknown. Organochlorine chemicals are known to be persistent and are found in agricultural land as well as US EPA Superfund sites, especially DDT, PCBs, …

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State Of Crime, 2018: A Look At Crime And Crime Response Needs In East Baton Rouge Parish, Hillar C. Moore Iii Mar 2018

State Of Crime, 2018: A Look At Crime And Crime Response Needs In East Baton Rouge Parish, Hillar C. Moore Iii

Reports

No abstract provided.

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My Year As A Fed, Prosanta Chakrabarty Mar 2018

My Year As A Fed, Prosanta Chakrabarty

Faculty Publications

No abstract provided.

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Chemotherapeutic Applications Of Rhodamine Based Nanogumbos, Nimisha Bhattarai Mar 2018

Chemotherapeutic Applications Of Rhodamine Based Nanogumbos, Nimisha Bhattarai

LSU Doctoral Dissertations

The work presented in this dissertation employs nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS) for selective chemotherapeutic applications. GUMBOS, similar to ionic liquids, are organic salts consisting of a bulky cationic and anionic moiety. In contrast to ionic liquids, these materials have melting points ranging from 25–250 °C, making them solid phase at room temperature. Similar to ionic liquids, GUMBOS display tunable properties, such as hydrophobicity and solubility, through counter ion variation. These tunable properties provide a variety of applications for these GUMBOS, including selective chemotherapeutics applications. The …

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Community Assembly Of The Ferns Of Florida, Emily B. Sessa, Sally M. Chambers, Daijiang Li, Lauren Trotta, Lorena Endara, J. Gordon Burleigh, Benjamin Baiser Mar 2018

Community Assembly Of The Ferns Of Florida, Emily B. Sessa, Sally M. Chambers, Daijiang Li, Lauren Trotta, Lorena Endara, J. Gordon Burleigh, Benjamin Baiser

Faculty Publications

© 2018 The Authors. American Journal of Botany is published by Wiley Periodicals, Inc. on behalf of the Botanical Society of America. Premise of the Study: Many ecological and evolutionary processes shape the assembly of organisms into local communities from a regional pool of species. We analyzed phylogenetic and functional diversity to understand community assembly of the ferns of Florida at two spatial scales. Methods: We built a phylogeny for 125 of the 141 species of ferns in Florida using five chloroplast markers. We calculated mean pairwise dissimilarity (MPD) and mean nearest taxon distance (MNTD) from phylogenetic distances and functional …

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Transcriptomics Reveal Transgenerational Effects In Purple Sea Urchin Embryos: Adult Acclimation To Upwelling Conditions Alters The Response Of Their Progeny To Differential Pco2 Levels, Juliet M. Wong, Kevin M. Johnson, Morgan W. Kelly, Gretchen E Hofmann Mar 2018

Transcriptomics Reveal Transgenerational Effects In Purple Sea Urchin Embryos: Adult Acclimation To Upwelling Conditions Alters The Response Of Their Progeny To Differential Pco2 Levels, Juliet M. Wong, Kevin M. Johnson, Morgan W. Kelly, Gretchen E Hofmann

Faculty Publications

© 2018 John Wiley & Sons Ltd Understanding the mechanisms with which organisms can respond to a rapidly changing ocean is an important research priority in marine sciences, especially in the light of recent predictions regarding the pace of ocean change in the coming decades. Transgenerational effects, in which the experience of the parental generation can shape the phenotype of their offspring, may serve as such a mechanism. In this study, adult purple sea urchins, Strongylocentrotus purpuratus, were conditioned to regionally and ecologically relevant pCO2 levels and temperatures representative of upwelling (colder temperature and high pCO2) and nonupwelling (average temperature …

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Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan Mar 2018

Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan

Faculty Publications

© 2018 The Obesity Society Objective: This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). Methods: After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, …

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Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan Mar 2018

Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan

Faculty Publications

© 2018 The Obesity Society Objective: This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). Methods: After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, …

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First Impressions—The Potential Of Altering Initial Host-Virus Interactions For Rational Design Of Herpesvirus Vaccine Vectors, Paul J.F. Rider, Farhana Musarrat, Rafiq Nabi, Shan Naidu, Konstantin G. Kousoulas Mar 2018

First Impressions—The Potential Of Altering Initial Host-Virus Interactions For Rational Design Of Herpesvirus Vaccine Vectors, Paul J.F. Rider, Farhana Musarrat, Rafiq Nabi, Shan Naidu, Konstantin G. Kousoulas

Faculty Publications

© 2018, Springer International Publishing AG, part of Springer Nature. Purpose of Review: The earliest host-virus interactions occur during virus attachment and entry into cells. These initial steps in the virus lifecycle influence the outcome of infection beyond delivery of the viral genome into the cell. Herpesviruses alter host signaling pathways and processes during attachment and entry to facilitate virus infection and modulate innate immune responses. We suggest in this review that understanding these early events may inform the rational design of therapeutic and prevention strategies for herpesvirus infection, as well as the engineering of viral vectors for immunotherapy purposes. …

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The Amino Terminus Of Herpes Simplex Virus 1 Glycoprotein K (Gk) Is Required For Gb Binding To Akt, Release Of Intracellular Calcium, And Fusion Of The Viral Envelope With Plasma Membranes, Farhana Musarrat, Nithya Jambunathan, Paul J.F. Rider, V. N. Chouljenko, K. G. Kousoulas Mar 2018

The Amino Terminus Of Herpes Simplex Virus 1 Glycoprotein K (Gk) Is Required For Gb Binding To Akt, Release Of Intracellular Calcium, And Fusion Of The Viral Envelope With Plasma Membranes, Farhana Musarrat, Nithya Jambunathan, Paul J.F. Rider, V. N. Chouljenko, K. G. Kousoulas

Faculty Publications

© 2018 American Society for Microbiology. Previously, we have shown that the amino terminus of glycoprotein K (gK) binds to the amino terminus of gB and that deletion of the aminoterminal 38 amino acids of gK prevents herpes simplex virus 1 (HSV-1) infection of mouse trigeminal ganglia after ocular infection and virus entry into neuronal axons. Recently, it has been shown that gB binds to Akt during virus entry and induces Akt phosphorylation and intracellular calcium release. Proximity ligation and two-way immunoprecipitation assays using monoclonal antibodies against gB and Akt-1 phosphorylated at S473 [Akt-1(S473)] confirmed that HSV-1(McKrae) gB interacted with …

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Upregulation Of Coilin Mrna Upon Nopp140-/- In Drosophila Melanogaster., Sara Grace Hubacek Mar 2018

Upregulation Of Coilin Mrna Upon Nopp140-/- In Drosophila Melanogaster., Sara Grace Hubacek

Honors Capstones

No abstract provided.

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Evaluation Of Surface And Shallow Depth Dose Reductions Using A Superflab Bolus During Conventional And Advanced External Beam Radiotherapy, Jihyung Yoon, Yibo Xie, Rui Zhang Mar 2018

Evaluation Of Surface And Shallow Depth Dose Reductions Using A Superflab Bolus During Conventional And Advanced External Beam Radiotherapy, Jihyung Yoon, Yibo Xie, Rui Zhang

Faculty Publications

The purpose of this study was to evaluate a methodology to reduce scatter and leakage radiations to patients' surface and shallow depths during conventional and advanced external beam radiotherapy. Superflab boluses of different thicknesses were placed on top of a stack of solid water phantoms, and the bolus effect on surface and shallow depth doses for both open and intensity-modulated radiotherapy (IMRT) beams was evaluated using thermoluminescent dosimeters and ion chamber measurements. Contralateral breast dose reduction caused by the bolus was evaluated by delivering clinical postmastectomy radiotherapy (PMRT) plans to an anthropomorphic phantom. For the solid water phantom measurements, surface …

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Low- And Middle-Income Countries Can Reduce Risks Of Subsequent Neoplasms By Referring Pediatric Craniospinal Cases To Centralized Proton Treatment Centers, Phillip J. Taddei, Nabil Khater, Bassem Youssef, Rebecca M. Howell, Wassim Jalbout, Rui Zhang, Fady B. Geara, Annelise Giebeler, Anita Mahajan, Dragan Mirkovic, Wayne D. Newhauser Mar 2018

Low- And Middle-Income Countries Can Reduce Risks Of Subsequent Neoplasms By Referring Pediatric Craniospinal Cases To Centralized Proton Treatment Centers, Phillip J. Taddei, Nabil Khater, Bassem Youssef, Rebecca M. Howell, Wassim Jalbout, Rui Zhang, Fady B. Geara, Annelise Giebeler, Anita Mahajan, Dragan Mirkovic, Wayne D. Newhauser

Faculty Publications

Few children with cancer in low- and middle-income countries (LMICs) have access to proton therapy. Evidence exists to support replacing photon therapy with proton therapy to reduce the incidence of secondary malignant neoplasms (SMNs) in childhood cancer survivors. The purpose of this study was to estimate the potential reduction in SMN incidence and in SMN mortality for pediatric medulloblastoma (MB) patients in LMICs if proton therapy were made available to them. For nine children of ages 2-14 years, we calculated the equivalent dose in organs or tissues at risk for radiogenic SMNs from therapeutic and stray radiation for photon craniospinal …

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Development Of The (D; N) Proton-Transfer Reaction In Inverse Kinematics For Structure Studies, K. L. Jones, C. Thornsberry, J. Allen, A. Atencio, D. W. Bardayan, D. Blankstein, S. Burcher, A. B. Carter, K. A. Chipps, J. A. Cizewski, I. Cox, Z. Elledge, M. Febbraro, A. Fijałkowska, R. Grzywacz, M. R. Hall, T. T. King, A. Lepailleur, M. Madurga, S. T. Marley, P. D. O'Malley, S. V. Paulauskas, S. D. Pain, W. A. Peters, C. Reingold, K. Smith, S. Taylor, W. Tan, M. Vostinar, D. Walter Mar 2018

Development Of The (D; N) Proton-Transfer Reaction In Inverse Kinematics For Structure Studies, K. L. Jones, C. Thornsberry, J. Allen, A. Atencio, D. W. Bardayan, D. Blankstein, S. Burcher, A. B. Carter, K. A. Chipps, J. A. Cizewski, I. Cox, Z. Elledge, M. Febbraro, A. Fijałkowska, R. Grzywacz, M. R. Hall, T. T. King, A. Lepailleur, M. Madurga, S. T. Marley, P. D. O'Malley, S. V. Paulauskas, S. D. Pain, W. A. Peters, C. Reingold, K. Smith, S. Taylor, W. Tan, M. Vostinar, D. Walter

Faculty Publications

Transfer reactions have provided exciting opportunities to study the structure of exotic nuclei and are often used to inform studies relating to nucleosynthesis and applications. In order to benefit from these reactions and their application to rare ion beams (RIBs), it is necessary to develop the tools and techniques to perform and analyze the data from reactions performed in inverse kinematics, that is with targets of light nuclei and heavier beams. We are continuing to expand the transfer reaction toolbox in preparation for the next generation of facilities, such as the Facility for Rare Ion Beams (FRIB), which is scheduled …

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The Resolved Stellar Populations In The Legus Galaxies1, E. Sabbi, D. Calzetti, L. Ubeda, A. Adamo, M. Cignoni, D. Thilker, A. Aloisi, B. G. Elmegreen, D. M. Elmegreen, D. A. Gouliermis, E. K. Grebel, M. Messa, L. J. Smith, M. Tosi, A. Dolphin, J. E. Andrews, G. Ashworth, S. N. Bright, T. M. Brown, R. Chandar, C. Christian, G. C. Clayton, D. O. Cook, D. A. Dale, S. E. De Mink, C. Dobbs, A. S. Evans, M. Fumagalli, J. S. Gallagher, K. Grasha, A. Herrero, D. A. Hunter, K. E. Johnson Mar 2018

The Resolved Stellar Populations In The Legus Galaxies1, E. Sabbi, D. Calzetti, L. Ubeda, A. Adamo, M. Cignoni, D. Thilker, A. Aloisi, B. G. Elmegreen, D. M. Elmegreen, D. A. Gouliermis, E. K. Grebel, M. Messa, L. J. Smith, M. Tosi, A. Dolphin, J. E. Andrews, G. Ashworth, S. N. Bright, T. M. Brown, R. Chandar, C. Christian, G. C. Clayton, D. O. Cook, D. A. Dale, S. E. De Mink, C. Dobbs, A. S. Evans, M. Fumagalli, J. S. Gallagher, K. Grasha, A. Herrero, D. A. Hunter, K. E. Johnson

Faculty Publications

The Legacy ExtraGalactic UV Survey (LEGUS) is a multiwavelength Cycle 21 Treasury program on the Hubble Space Telescope. It studied 50 nearby star-forming galaxies in 5 bands from the near-UV to the I-band, combining new Wide Field Camera 3 observations with archival Advanced Camera for Surveys data. LEGUS was designed to investigate how star formation occurs and develops on both small and large scales, and how it relates to the galactic environments. In this paper we present the photometric catalogs for all the apparently single stars identified in the 50 LEGUS galaxies. Photometric catalogs and mosaicked images for all filters …

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Editorial, David A. Spivak Mar 2018

Editorial, David A. Spivak

Faculty Publications

No abstract provided.

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Estimating Surface/Subsurface Sediment Mixing In Karst Settings Using 7Be Isotopes, C. M. Wicks, R. L. Paylor, S. J. Bentley Mar 2018

Estimating Surface/Subsurface Sediment Mixing In Karst Settings Using 7Be Isotopes, C. M. Wicks, R. L. Paylor, S. J. Bentley

Faculty Publications

© 2018 The Authors. This study shows that the cosmogenic radionuclide beryllium-7 can be used to track sediment movement through caves. The activities of beryllium-7 and cesium-137 were measured in two different karst settings at both surface and subsurface sites before and after storm runoff events. At one site, 7Be-enriched sediment was detected up to 1.5 km along a stream conduit after a moderate storm event; however, the activity of 137Cs was too variable to show a meaningful pattern. The percentages of surface sediment that was found ranged from 0 to 52% along the entire 3 km cave stream and …

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Erratum: Climatic And Glacial Impact On Erosion Patterns And Sediment Provenance In The Himalayan Rain Shadow, Zanskar River, Nw India [The Geological Society Of America, 129, 7, 8, (2017), (820-836)] Doi: 10.1130/B31573.1, Tara N. Jonell, Andrew Carter, Philipp Böning, Katharina Pahnke, Peter D. Clift Mar 2018

Erratum: Climatic And Glacial Impact On Erosion Patterns And Sediment Provenance In The Himalayan Rain Shadow, Zanskar River, Nw India [The Geological Society Of America, 129, 7, 8, (2017), (820-836)] Doi: 10.1130/B31573.1, Tara N. Jonell, Andrew Carter, Philipp Böning, Katharina Pahnke, Peter D. Clift

Faculty Publications

© 2018 Geological Society of America. ORIGINAL ARTICLE: 2017, v. 129, no. 7/8, p. 820-836, https://doi.org/10.1130/B31573.1. First published 28 April 2017. ERRATUM PUBLICATION: 2019, v. 131, no. 3/4, p. 704, https://doi.org/10.1130/B31573E.1. First published 31 January 2019. Several erroneous values were identified in Table 2 on page 824 that resulted from improper cell value referencing. All values are corrected and reflect the average compositions normalized to 100 grains. The corrected table is seen here.

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The Mediating Role Of Korean Immigrant Mothers’ Psychological Well-Being In The Associations Between Social Support And Authoritarian Parenting Style, You Jung Seo, Charissa S.L. Cheah, Sevgi Bayram Özdemir, Craig H. Hart, Christy Y.Y. Leung, Shuyan Sun Mar 2018

The Mediating Role Of Korean Immigrant Mothers’ Psychological Well-Being In The Associations Between Social Support And Authoritarian Parenting Style, You Jung Seo, Charissa S.L. Cheah, Sevgi Bayram Özdemir, Craig H. Hart, Christy Y.Y. Leung, Shuyan Sun

Faculty Publications

© 2017, Springer Science+Business Media, LLC. We examined the mediating role of Korean immigrant mothers’ psychological well-being in the associations between mothers’ emotional vs. instrumental support received from their kin, and their authoritarian parenting style with their preschoolers using longitudinal data. First-generation Korean immigrant mothers with preschool-aged children (N = 158; Mmaternal age = 36.11 years, SD = 3.90; Mchild age = 4.43 years, SD = 1.10) residing in Maryland, U.S., participated in three assessment waves. Each assessment wave was 6 months apart. Mothers reported on the amount of perceived emotional and instrumental support they received from their kin, their …

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Effects Of Truck-Mounted, Ultra Low Volume Mosquito Adulticides On Honey Bees (Apis Mellifera) In A Suburban Field Setting, Vivek Pokhrel, Nicholas A. Delisi, Robert G. Danka, Todd W. Walker, James A. Ottea, Kristen B. Healy Mar 2018

Effects Of Truck-Mounted, Ultra Low Volume Mosquito Adulticides On Honey Bees (Apis Mellifera) In A Suburban Field Setting, Vivek Pokhrel, Nicholas A. Delisi, Robert G. Danka, Todd W. Walker, James A. Ottea, Kristen B. Healy

Faculty Publications

Few studies have examined the impact of mosquito adulticides on honey bees under conditions that reflect actual field exposure. Whereas several studies have evaluated the toxicity of mosquito control products on honey bees, most have been laboratory based and have focused solely on acute mortality as a measure of impact. The goal of this study was to determine effects of routine applications of truck-based ultra-low volume (ULV) mosquito adulticides (i.e., Scourge, Duet, and Deltagard) on honey bees in a suburban setting. The mosquito adulticides used in this study were pyrethroids with active ingredients resmethrin (Scourge), prallethrin and sumithrin (Duet), and …

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Trans-Ethnic Analysis Of Metabochip Data Identifies Two New Loci Associated With Bmi, J. Gong, K. K. Nishimura, L. Fernandez-Rhodes, J. Haessler, S. Bien, M. Graff, U. Lim, Y. Lu, M. Gross, M. Fornage, S. Yoneyama, C. R. Isasi, P. Buzkova, M. Daviglus, D. Y. Lin, R. Tao, R. Goodloe, W. S. Bush, E. Farber-Eger, J. Boston, H. H. Dilks, G. Ehret, C. C. Gu, C. E. Lewis, K. D.H. Nguyen, R. Cooper, M. Leppert, M. R. Irvin, E. P. Bottinger, L. R. Wilkens, C. A. Haiman, L. Park, K. R. Monroe Mar 2018

Trans-Ethnic Analysis Of Metabochip Data Identifies Two New Loci Associated With Bmi, J. Gong, K. K. Nishimura, L. Fernandez-Rhodes, J. Haessler, S. Bien, M. Graff, U. Lim, Y. Lu, M. Gross, M. Fornage, S. Yoneyama, C. R. Isasi, P. Buzkova, M. Daviglus, D. Y. Lin, R. Tao, R. Goodloe, W. S. Bush, E. Farber-Eger, J. Boston, H. H. Dilks, G. Ehret, C. C. Gu, C. E. Lewis, K. D.H. Nguyen, R. Cooper, M. Leppert, M. R. Irvin, E. P. Bottinger, L. R. Wilkens, C. A. Haiman, L. Park, K. R. Monroe

Faculty Publications

Objective:Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been shown to be a heritable, polygenic trait, with close to 100 loci previously identified and replicated in multiple populations. We aim to replicate known BMI loci and identify novel associations in a trans-ethnic study population.Subjects:Using eligible participants from the Population Architecture using Genomics and Epidemiology consortium, we conducted a trans-ethnic meta-analysis of 102 514 African Americans, Hispanics, Asian/Native Hawaiian, Native Americans and European Americans. Participants were genotyped on over 200 000 SNPs on the Illumina Metabochip custom …

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A Large-Scale Multi-Ancestry Genome-Wide Study Accounting For Smoking Behavior Identifies Multiple Significant Loci For Blood Pressure, Yun J. Sung, Thomas W. Winkler, Lisa De Las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Tuomas O. Kilpeläinen, Melissa A. Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M. Bartz, Rajkumar Dorajoo, Yongmei Liu, Alisa K. Manning, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Helen R. Warren, Wei Zhao Mar 2018

A Large-Scale Multi-Ancestry Genome-Wide Study Accounting For Smoking Behavior Identifies Multiple Significant Loci For Blood Pressure, Yun J. Sung, Thomas W. Winkler, Lisa De Las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Tuomas O. Kilpeläinen, Melissa A. Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M. Bartz, Rajkumar Dorajoo, Yongmei Liu, Alisa K. Manning, Tuomo Rankinen, Albert Vernon Smith, Salman M. Tajuddin, Bamidele O. Tayo, Helen R. Warren, Wei Zhao

Faculty Publications

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10−8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 × 10−8). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).

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Field Efficacy Of Bacillus Thuringiensis Galleriae Strain Sds-502 For The Management Of Alfalfa Weevil And Its Impact On Bathyplectes Spp. Parasitization Rate, Govinda Shrestha, Gadi V.P. Reddy, Stefan T. Jaronski Mar 2018

Field Efficacy Of Bacillus Thuringiensis Galleriae Strain Sds-502 For The Management Of Alfalfa Weevil And Its Impact On Bathyplectes Spp. Parasitization Rate, Govinda Shrestha, Gadi V.P. Reddy, Stefan T. Jaronski

Faculty Publications

Alfalfa weevil, Hypera postica Gyllenhal, is an important pest in forage alfalfa worldwide, and especially so on the Northern Plains of North America. Neither the weevil-specific fungus, Erynia phytonomi, nor the weevil's parasitoids are able to routinely suppress outbreaks as they do in the eastern U.S. A new Bacillus thuringiensis var. galleriae, having a Cry8Da coleopteran-active toxin, has been recently commercialized. We examined the efficacy of this B. thuringiensis product against the H. postica in replicated field trials in north central Montana. Because it has been suggested that efficiency of the parasitoids, Bathyplectes curculionis and Oomyzus incertus, was inversely proportional …

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Optimal Number And Location Of Storage Hubs And Biogas Production Reactors In Farmlands With Allocation Of Multiple Feedstocks, Bhaba R. Sarker, Bingqing Wu, Krishna P. Paudel Mar 2018

Optimal Number And Location Of Storage Hubs And Biogas Production Reactors In Farmlands With Allocation Of Multiple Feedstocks, Bhaba R. Sarker, Bingqing Wu, Krishna P. Paudel

Faculty Publications

© 2017 Elsevier Inc. This paper focuses on the problem for designing a logistics system for bio-methane gas (BMG) production. In practice, farm residues such as crop residue, wood residue, and livestock manure are used in reactors as reactants to generate BMG. A multi-residue, multi-hub, multi-reactor location-allocation model is developed to design the logistics of BMG production system. Both the hubs’ and reactors’ locations, and the residue's distribution plan are investigated to minimize the total construction and logistical cost. The costs of construction, transportation, feedstocks and labor are taken into consideration to reflect the lifecycle cost of the entire undertaking. …

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Impact Of Model Violations On The Inference Of Species Boundaries Under The Multispecies Coalescent, Anthony J. Barley, Jeremy M. Brown, Robert C. Thomson Mar 2018

Impact Of Model Violations On The Inference Of Species Boundaries Under The Multispecies Coalescent, Anthony J. Barley, Jeremy M. Brown, Robert C. Thomson

Faculty Publications

© 2017 The Author(s). The use of genetic data for identifying species-level lineages across the tree of life has received increasing attention in the field of systematics over the past decade. The multispecies coalescent model provides a framework for understanding the process of lineage divergence and has become widely adopted for delimiting species. However, because these studies lack an explicit assessment of model fit, in many cases, the accuracy of the inferred species boundaries are unknown. This is concerning given the large amount of empirical data and theory that highlight the complexity of the speciation process. Here, we seek to …

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Reply To Comment By Vincent Et Al., Eric Cowgill, Nathan A. Niemi, Adam M. Forte, Charles C. Trexler Mar 2018

Reply To Comment By Vincent Et Al., Eric Cowgill, Nathan A. Niemi, Adam M. Forte, Charles C. Trexler

Faculty Publications

No abstract provided.

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