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Synthesis And Characterization Of Polyaniline Agglomerates And Polyaniline Nanoparticles To Use As Printed Sensors To Detect Spoilage Of Catfish During Refrigerated Storage, Vashti Martae Campbell Jul 2018

Synthesis And Characterization Of Polyaniline Agglomerates And Polyaniline Nanoparticles To Use As Printed Sensors To Detect Spoilage Of Catfish During Refrigerated Storage, Vashti Martae Campbell

LSU Master's Theses

There is growing interest in the development of sensors contained in packaging for seafood that are applicable at the consumer level to monitor freshness in a non-destructive manner. Total volatile basic nitrogen (TVB-N) analysis indicates the freshness of seafood. TVB-N analysis is sensitive to the spoilage compounds comprised of ammonia, trimethylamine, dimethylamine, and biogenic amines commonly found in seafood and whose concentration increases when spoilage microbial growth occurs. However, TVB-N analysis is laborious and is not suitable for use at the consumer level. Polyaniline (PANI) is a polymer that may be used as a sensor for detecting TVB-N in seafood. …

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Le Roman Policier Francophone : Entre Esthétique Et Politiques Du Genre En Afrique Et En Haïti, Lise Madeleine Mba Ekani Jul 2018

Le Roman Policier Francophone : Entre Esthétique Et Politiques Du Genre En Afrique Et En Haïti, Lise Madeleine Mba Ekani

LSU Doctoral Dissertations

My dissertation, “Recasting Crime Fiction: The Francophone African and Haitian Crime Novel between Aesthetics and Politics”, investigates the social and literary meanings of the concept of politics as represented in African and Haitian crime novels. In this work, selected novels were examined considering their cultural, regional and linguistic particularities, as well as their perspectives on social criticism and politics. Drawing from fields such as sociocritical theory, philosophy, and history, this work allows for a more complex exploration of popular cultural productions while calling into question the literary genres. Consequently, it provides the opportunity to question cultural productions as an ideological …

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A Bayesian Phase I/Ii Trial Design For Immunotherapy, Suyu Liu, Beibei Guo, Ying Yuan Jul 2018

A Bayesian Phase I/Ii Trial Design For Immunotherapy, Suyu Liu, Beibei Guo, Ying Yuan

Faculty Publications

Immunotherapy is an innovative treatment approach that stimulates a patient’s immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dose-finding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity, and efficacy. The objective is to identify the biologically optimal dose, defined as the dose with the highest desirability in the risk–benefit tradeoff. An Emax model is utilized to describe the marginal distribution of the immune response. Conditional on the immune response, we jointly model toxicity and efficacy using …

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Frequency Dependent Deformation Reversibility During Cyclic Loading, Shuai Shao, Michael M. Khonsari, Jian Wang, Nima Shamsaei, Nan Li Jul 2018

Frequency Dependent Deformation Reversibility During Cyclic Loading, Shuai Shao, Michael M. Khonsari, Jian Wang, Nima Shamsaei, Nan Li

Faculty Publications

High-frequency testing (HFT) is useful for accelerated fatigue testing of conventional materials that typically serve under low-frequency loading conditions, as well as for the assessment of the robustness of microelectromechanical systems which typically experience high-frequency service conditions. Using discrete dislocation dynamics, we attempt to elucidate the effect of loading frequency on the reversibility of cyclic deformation. We demonstrate that the HFT induces a higher fraction of reversible cyclic deformation because of a larger portion of elastic/anelastic deformation due to limited dislocation mobility, and a higher degree of reversibility in plastic deformation owing to the less occurrence of cross-slip. (Image presented) …

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Modeling And Analysis Of Thermal Effects On A Fractured Wellbore During Lost Circulation And Wellbore Strengthening Processes, Ze Wang Jul 2018

Modeling And Analysis Of Thermal Effects On A Fractured Wellbore During Lost Circulation And Wellbore Strengthening Processes, Ze Wang

LSU Master's Theses

To successfully prevent fracture propagation and combat lost circulation, a thorough understanding of the stress state in the near-wellbore region with fractures is imperative. One important factor that is not yet fully understood is how temperature variation during lost circulation affects pre-existing or newly initiated fractures. To address this problem, a 3D finite element analysis was conducted in this study to simulate the transport processes and state of stresses in the near-wellbore region during mud invasion into fractures. To take the thermal effects into account, a thermo-poro-elasticity model was coupled with flow and heat transfer processes. This study included a …

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Integrated Reservoir-Wellbore Nodal Analysis Workflow For Worst-Case Discharge Modeling, Florencia Anahi Vasquez Cordoba Jul 2018

Integrated Reservoir-Wellbore Nodal Analysis Workflow For Worst-Case Discharge Modeling, Florencia Anahi Vasquez Cordoba

LSU Master's Theses

According to the Bureau of Ocean Energy Management (BOEM), worst-case discharge (WCD) is the single highest possible daily flow rate of liquid hydrocarbon during an uncontrolled wellbore flow event [49]. The main objective of this research is to develop a workflow to calculate worst case discharge (WCD) volumes for a drilling scenario using an integrated reservoir-nodal analyses approach. Using robust integrated production modeling (IPM) tools, a nodal analysis workflow is developed to compute WCD volumes and rates that operators can use easily if they have IPM, or adapt to using a different software (including excel) in absence of IPM. A …

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A Study On The Direct And Moderating Effects Of Leader Facilitated Workplace Learning And Leader-Member Exchange On Employee Engagement, Candi S. Mcelheny Jul 2018

A Study On The Direct And Moderating Effects Of Leader Facilitated Workplace Learning And Leader-Member Exchange On Employee Engagement, Candi S. Mcelheny

LSU Doctoral Dissertations

Employee engagement (EE) is a problem across all industries and is especially troublesome in the nursing profession. However the existing literature, both within and outside nursing professional publications, does not offer explicit solutions for combatting the current EE dilemma. The primary purpose of this study was to test a researcher-developed causal model linking Leader Facilitated Workplace Learning (LFWL), Leader-Member Exchange (LMX), and EE. LFWL, a new construct, was proposed as an antecedent for LMX and EE. Furthermore, LFWL was posited to have a moderating effect on the LMX and EE relationship. The model was tested using structural equation modeling (SEM). …

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Evaluation Of Oncolytic And Immunomodulatory Potential Of The Hsv-1 Live-Attenuated Vaccine Strain Vc2 In An Immunocompetent Murine Melanoma Model, Natalie Wall Fowlkes Jul 2018

Evaluation Of Oncolytic And Immunomodulatory Potential Of The Hsv-1 Live-Attenuated Vaccine Strain Vc2 In An Immunocompetent Murine Melanoma Model, Natalie Wall Fowlkes

LSU Doctoral Dissertations

Melanoma accounts for 90% of skin cancer-related deaths in humans. Treatment options for metastatic melanoma in people is very limited. Melanoma is considered to be an immunogenic tumor, spurring interest in development of immunotherapies for the treatment of metastatic melanoma. Oncolytic virotherapy has been widely investigated. The first ever oncolytic virotherapy to receive FDA-approval is an HSV-1-based virus (Talimogene Laherperavec (T-Vec) or Imlygic) containing a transgene for human GM-CSF to enhance anti-tumor immune responses after injection. Durable response rate in human patients was only 16% despite impressive efficacy in anti-tumor effects in vitro and in murine tumor models. Novel viruses …

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Asynchronous Execution Of Python Code On Task-Based Runtime Systems, R. Tohid, Bibek Wagle, Shahrzad Shirzad, Patrick Diehl, Adrian Serio, Alireza Kheirkhahan, Parsa Amini, Katy Williams, Kate Isaacs, Kevin Huck, Steven Brandt, Hartmut Kaiser Jul 2018

Asynchronous Execution Of Python Code On Task-Based Runtime Systems, R. Tohid, Bibek Wagle, Shahrzad Shirzad, Patrick Diehl, Adrian Serio, Alireza Kheirkhahan, Parsa Amini, Katy Williams, Kate Isaacs, Kevin Huck, Steven Brandt, Hartmut Kaiser

Faculty Publications

Despite advancements in the areas of parallel and distributed computing, the complexity of programming on High Performance Computing (HPC) resources has deterred many domain experts, especially in the areas of machine learning and artificial intelligence (AI), from utilizing performance benefits of such systems. Researchers and scientists favor high-productivity languages to avoid the inconvenience of programming in low-level languages and costs of acquiring the necessary skills required for programming at this level. In recent years, Python, with the support of linear algebra libraries like NumPy, has gained popularity despite facing limitations which prevent this code from distributed runs. Here we present …

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Integration Of Cuda Processing Within The C++ Library For Parallelism And Concurrency (Hpx), Patrick Diehl, Madhavan Seshadri, Thomas Heller, Hartmut Kaiser Jul 2018

Integration Of Cuda Processing Within The C++ Library For Parallelism And Concurrency (Hpx), Patrick Diehl, Madhavan Seshadri, Thomas Heller, Hartmut Kaiser

Faculty Publications

Experience shows that on today's high performance systems the utilization of different acceleration cards in conjunction with a high utilization of all other parts of the system is difficult. Future architectures, like exascale clusters, are expected to aggravate this issue as the number of cores are expected to increase and memory hierarchies are expected to become deeper. One big aspect for distributed applications is to guarantee high utilization of all available resources, including local or remote acceleration cards on a cluster while fully using all the available CPU resources and the integration of the GPU work into the overall programming …

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Residual Effects Of Termiticides On Mortality Of Formosan Subterranean Termites, Coptotermes Formosanus Shiraki, In Substrates Subjected To Flooding, Rajani Sapkota Jul 2018

Residual Effects Of Termiticides On Mortality Of Formosan Subterranean Termites, Coptotermes Formosanus Shiraki, In Substrates Subjected To Flooding, Rajani Sapkota

LSU Master's Theses

Formosan subterranean termites (Coptotermes formosanus Shiraki) are one of the most important economic insects in the Southern US since they cause severe and costly damage to properties. Soil treatment with termiticides is the most widely used and reliable method for termite prevention, but their efficacy after a home floods, an all too common event for a homeowner in recent years, has prompted many pest control companies to suggest a new treatment is necessary. This can be expensive and possibly unnecessary. However, several factors such as termiticide water solubility and binding properties, soil type and soil leachability and the inherent …

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Predicting River Stage Using Recurrent Neural Networks, Eric Rohli Jul 2018

Predicting River Stage Using Recurrent Neural Networks, Eric Rohli

LSU Master's Theses

River stage prediction is an important problem in the water transportation industry. Accurate river stage predictions provide crucial information to barge and tow boat operators, port terminal captains, and lock management officials. Shallow river levels caused by prolonged drought impact the loading capacity of barges and tow boats. High river levels caused by excessive rainfall or snowmelt allow for greater tow capacities but make downstream transportation and lock management risky. Current academic river height prediction systems utilize either time series statistical analysis or machine learning algorithms to forecast future river heights, but systems that combine these two areas often limit …

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How Courts Analyze Voter Identification Laws Under The First Amendment, Joby Len Richard Jul 2018

How Courts Analyze Voter Identification Laws Under The First Amendment, Joby Len Richard

LSU Master's Theses

Some scholarship and political experts describe voter ID laws as a form of voter suppression because they make it harder for certain groups of people to vote. First, this thesis considers the historical backdrop of voter discrimination resulting in the passage of the Voting Rights Act of 1965, and subsequent state uses of registration and voter ID laws. Then, this study reviews the theoretical foundation of freedom of expression as developed by Thomas Emerson and individual and social free expression values, including the social value of self-governance explicated by Alexander Meiklejohn. Some scholars also suggest that voter ID laws may …

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Groundwater And Thermal Legacy Of A Large Paleolake In Taylor Valley, East Antarctica As Evidenced By Airborne Electromagnetic And Sedimentological Techniques, Krista Falcon Myers Jul 2018

Groundwater And Thermal Legacy Of A Large Paleolake In Taylor Valley, East Antarctica As Evidenced By Airborne Electromagnetic And Sedimentological Techniques, Krista Falcon Myers

LSU Master's Theses

During the Last Glacial Maximum, grounded ice in the Ross Sea extended into the otherwise ice-free McMurdo Dry Valleys, creating a series of large ice dammed paleolakes. Grounded ice within the mouth of Taylor Valley allowed for lake levels to reach elevations not possible at modern day and formed what is known as Glacial Lake Washburn (GLW). GLW extended from the eastern portion of Taylor Valley roughly 20 km west to a level ~300 m higher than modern day Lake Fryxell. The formation and existence of GLW has been debated, though previous studies correlate the timing of GLW with early …

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Curve Tracking Control Under State Constraints And Uncertainties, Robert Kelly Sizemore Jul 2018

Curve Tracking Control Under State Constraints And Uncertainties, Robert Kelly Sizemore

LSU Doctoral Dissertations

We study a class of steering control problems for free-moving particles tracking a curve in the plane and also in a three-dimensional environment, which are central problems in robotics. In the two-dimensional case, we provide adaptive controllers for curve tracking under unknown curvatures and control uncertainty. The system dynamics include a nonlinear dependence on the curvature, and are coupled with an estimator for the unknown curvature to form the augmented error dynamics. This nonlinear dependence puts our curvature identification objective outside the scope of existing adaptive tracking and parameter identification results that were limited to cases where the unknown parameters …

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How Do New Media Environments Influence Consumer Responses To Advertising? A Meta-Analytic Approach To Ad Avoidance, A-Reum Jung Jul 2018

How Do New Media Environments Influence Consumer Responses To Advertising? A Meta-Analytic Approach To Ad Avoidance, A-Reum Jung

LSU Doctoral Dissertations

This study aims to a) identify a comprehensive list of the antecedents and consequences of ad avoidance, b) examine how strongly they relate to ad avoidance, and c) investigate how those relationships differ across media formats. In order to fulfill these purposes, two studies (a meta-analysis and an online survey) were conducted. The meta-analysis yielded 52 antecedents and 7 consequences. Ad-related perception, ad tactics, personal characteristics, ad exposure conditions, personal experiences, and demographic information were major categories of antecedents. Decreased cognitive abilities to recall and recognize ad messages were primary consequences of advertising avoidance. In addition, the survey found that …

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Island Edge Morphodynamics Along A Chronosequence In A Prograding Deltaic Floodplain Wetland, Azure E. Bevington, Robert R. Twilley Jul 2018

Island Edge Morphodynamics Along A Chronosequence In A Prograding Deltaic Floodplain Wetland, Azure E. Bevington, Robert R. Twilley

Faculty Publications

Much of the previous research on coastal deltaic land building has focused on the planform delta dimensions; whereas this research focuses on shifts in vertical elevation and deltaic island edge cross-sectional morphology in relation to a proposed conceptual model of deltaic island edge morphological development. This study was conducted using data collected from the Wax Lake Delta in the northern Gulf of Mexico. Island edge cross-sectional elevation profiles were extracted from a 2012 LIDAR elevation survey. Four morphometric variables (levee width, interior slope, mean elevation range, and total elevation range) were selected to describe the shape of each of these …

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Malleilactone Is A Burkholderia Pseudomallei Virulence Factor Regulated By Antibiotics And Quorum Sensing, Jennifer R. Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D. Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R. Seyedsayamdost, Blake R. Peterson, Mario Rivera, Josephine R. Chandler Jul 2018

Malleilactone Is A Burkholderia Pseudomallei Virulence Factor Regulated By Antibiotics And Quorum Sensing, Jennifer R. Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D. Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R. Seyedsayamdost, Blake R. Peterson, Mario Rivera, Josephine R. Chandler

Faculty Publications

© 2018 American Society for Microbiology. Burkholderia pseudomallei, the causative agent of melioidosis, encodes almost a dozen predicted polyketide (PK) biosynthetic gene clusters. Many of these are regulated by LuxR-I-type acyl-homoserine (AHL) quorum-sensing systems. One of the PK gene clusters, the mal gene cluster, is conserved in the close relative Burkholderia thailandensis. The B. thailandensis mal genes code for the cytotoxin malleilactone and are regulated by a genetically linked LuxR-type transcription factor, MalR. Although AHLs typically interact with LuxR-type proteins to modulate gene transcription, the B. thailandensis MalR does not appear to be an AHL receptor. Here, we characterize the …

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Ard1/Naa10 Acetylation In Prostate Cancer, Katherine J. Kuhns, Guanyi Zhang, Zehua Wang, Wanguo Liu Jul 2018

Ard1/Naa10 Acetylation In Prostate Cancer, Katherine J. Kuhns, Guanyi Zhang, Zehua Wang, Wanguo Liu

Faculty Publications

© 2018, The Author(s). Prostate cancer (PCa) is the second most common cancer in men. Androgen receptor (AR) signaling pathway plays a crucial role in prostate development and homeostasis. Dysregulation of this pathway activates AR leading to PCa pathogenesis and progression. AR binds testosterone and other male hormones, which then undergoes post-translational modification for AR nuclear translocation and transcriptional activation. AR activation by post-translational modification is thus imperative for PCa cell growth and survival. Identification and understanding of the pathological and mechanistic roles of AR modifications may increase our understanding of AR activation in PCa and provide new therapeutic options. …

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Sales Impacts Of Direct Marketing Choices: Treatment Effects With Multinomial Selectivity, Timothy Park, Krishna Paudel, Seydina Sene Jul 2018

Sales Impacts Of Direct Marketing Choices: Treatment Effects With Multinomial Selectivity, Timothy Park, Krishna Paudel, Seydina Sene

Faculty Publications

Producers who are planning to sell using direct marketing to consumers only or to both consumers and retailers experience declines in total sales. Based on survey data for US farmers from 2008 to 2010, the earnings decline is 71.3 per cent when marketing direct to consumers and 36.8 per cent for the diversified marketing decision. The direct marketing penalty is robust to inclusion of important demographic factors, farm experience and use of the internet, and characteristics of the farm operation such as crop choices and input use. Direct marketing is associated with higher sales declines for female farmers, highlighting a …

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The Behavior Of Metropolis-Coupled Markov Chains When Sampling Rugged Phylogenetic Distributions, Jeremy M. Brown, Robert C. Thomson Jul 2018

The Behavior Of Metropolis-Coupled Markov Chains When Sampling Rugged Phylogenetic Distributions, Jeremy M. Brown, Robert C. Thomson

Faculty Publications

© The Author(s) 2018. Bayesian phylogenetic inference relies on the use of Markov chain Monte Carlo (MCMC) to provide numerical approximations of high-dimensional integrals and estimate posterior probabilities. However, MCMC performs poorly when posteriors are very rugged (i.e., regions of high posterior density are separated by regions of low posterior density). One technique that has become popular for improving numerical estimates from MCMC when distributions are rugged is Metropolis coupling (MC3). InMC3, additional chains are employed to sample flattened transformations of the posterior and improve mixing. Here, we highlight several underappreciated behaviors of MC3. Notably, estimated posterior probabilities may be …

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Liquid Sucrose Consumption Promotes Obesity And Impairs Glucose Tolerance Without Altering Circulating Insulin Levels, Susan J. Burke, Heidi M. Batdorf, Thomas M. Martin, David H. Burk, Robert C. Noland, Christopher R. Cooley, Michael D. Karlstad, William D. Johnson, J. Jason Collier Jul 2018

Liquid Sucrose Consumption Promotes Obesity And Impairs Glucose Tolerance Without Altering Circulating Insulin Levels, Susan J. Burke, Heidi M. Batdorf, Thomas M. Martin, David H. Burk, Robert C. Noland, Christopher R. Cooley, Michael D. Karlstad, William D. Johnson, J. Jason Collier

Faculty Publications

© 2018 The Obesity Society Objective: Multiple factors contribute to the rising rates of obesity and to difficulties in weight reduction that exist in the worldwide population. Caloric intake via sugar-sweetened beverages may be influential. This study tested the hypothesis that liquid sucrose intake promotes obesity by increasing serum insulin levels and tissue lipid accumulation. Methods: C57BL/6J mice were given 30% sucrose in liquid form. Changes in weight gain, body composition, energy expenditure (EE), and tissue lipid content were measured. Results: Mice drinking sucrose gained more total body mass (TBM), had greater fat mass, and displayed impaired glucose tolerance relative …

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Louisiana Agriculture Summer, 2018, Lsu Agcenter Jul 2018

Louisiana Agriculture Summer, 2018, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Evaluation Of A Mixed Beam Therapy For Postmastectomy Breast Cancer Patients: Bolus Electron Conformal Therapy Combined With Intensity Modulated Photon Radiotherapy And Volumetric Modulated Photon Arc Therapy, Rui Zhang, David Heins, Mary Sanders, Beibei Guo, Kenneth Hogstrom Jul 2018

Evaluation Of A Mixed Beam Therapy For Postmastectomy Breast Cancer Patients: Bolus Electron Conformal Therapy Combined With Intensity Modulated Photon Radiotherapy And Volumetric Modulated Photon Arc Therapy, Rui Zhang, David Heins, Mary Sanders, Beibei Guo, Kenneth Hogstrom

Faculty Publications

Purpose: The purpose of this study was to assess the potential benefits and limitations of a mixed beam therapy, which combined bolus electron conformal therapy (BECT) with intensity modulated photon radiotherapy (IMRT) and volumetric modulated photon arc therapy (VMAT), for left-sided postmastectomy breast cancer patients. Methods: Mixed beam treatment plans were produced for nine postmastectomy radiotherapy (PMRT) patients previously treated at our clinic with VMAT alone. The mixed beam plans consisted of 40 Gy to the chest wall area using BECT, 40 Gy to the supraclavicular area using parallel opposed IMRT, and 10 Gy to the total planning target volume …

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Glimpses Of Space-Time Beyond The Singularities Using Supercomputers, Parampreet Singh Jul 2018

Glimpses Of Space-Time Beyond The Singularities Using Supercomputers, Parampreet Singh

Faculty Publications

A fundamental problem of Einsteins theory of classical general relativity is the existence of singularities such as the big bang. All known laws of physics end at these boundaries of classical space-time. Thanks to recent developments in quantum gravity, supercomputers are now playing an important role in understanding the resolution of big bang and black hole singularities. Using supercomputers, explorations of the very genesis of space and time from quantum geometry are revealing a novel picture of what lies beyond classical singularities and the new physics of the birth of our universe.

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Measurement Of Inclusive Double-Differential Νμ Charged-Current Cross Section With Improved Acceptance In The T2k Off-Axis Near Detector, K. Abe, J. Amey, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, Y. Ashida, Y. Azuma, S. Ban, M. Barbi, G. J. Barker, G. Barr, C. Barry, M. Batkiewicz, V. Berardi, S. Berkman, R. M. Berner, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, S. Bordoni, B. Bourguille, S. B. Boyd, D. Brailsford, A. Bravar, C. Bronner Jul 2018

Measurement Of Inclusive Double-Differential Νμ Charged-Current Cross Section With Improved Acceptance In The T2k Off-Axis Near Detector, K. Abe, J. Amey, C. Andreopoulos, L. Anthony, M. Antonova, S. Aoki, A. Ariga, Y. Ashida, Y. Azuma, S. Ban, M. Barbi, G. J. Barker, G. Barr, C. Barry, M. Batkiewicz, V. Berardi, S. Berkman, R. M. Berner, S. Bhadra, S. Bienstock, A. Blondel, S. Bolognesi, S. Bordoni, B. Bourguille, S. B. Boyd, D. Brailsford, A. Bravar, C. Bronner

Faculty Publications

We report a measurement of the flux-integrated cross section for inclusive muon neutrino charged-current interactions on carbon. The double-differential measurements are given as a function of the muon momentum and angle. Relative to our previous publication on this topic, these results have an increased angular acceptance and higher statistics. The data sample presented here corresponds to 5.7×1020 protons on target. The total flux-integrated cross section is measured to be (6.950±0.662)×10-39 cm2 nucleon-1 and is consistent with our simulation.

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Synthesis And In Vitro Pdt Evaluation Of New Porphyrins Containing Meso-Epoxymethylaryl Cationic Groups, Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E. Griffin, Nichole E.M. Kaufman, Maria Da Graça Henriques Vicente Jul 2018

Synthesis And In Vitro Pdt Evaluation Of New Porphyrins Containing Meso-Epoxymethylaryl Cationic Groups, Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E. Griffin, Nichole E.M. Kaufman, Maria Da Graça Henriques Vicente

Faculty Publications

© 2018 Wiley Periodicals, Inc. Objectives: Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to develop efficient cationic photosensitizers for use in PDT. Materials and Methods: New porphyrins bearing cationic epoxymethylaryl groups were synthesized and characterized. Their cellular uptake, intracellular localization, and phototoxicity were evaluated in human HEp2 cells, and compared with their methylated analogs. Results: All cationic porphyrins were efficient generators of singlet oxygen, with …

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Inhibition Of Endocytosis Suppresses The Nitric Oxide-Dependent Release Of Cl- In Retinal Amacrine Cells, Vernon K. Dunn, Evanna Gleason Jul 2018

Inhibition Of Endocytosis Suppresses The Nitric Oxide-Dependent Release Of Cl- In Retinal Amacrine Cells, Vernon K. Dunn, Evanna Gleason

Faculty Publications

© 2018 Dunn, Gleason. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Our lab has previously shown that nitric oxide (NO) can alter the synaptic response properties of amacrine cells by releasing Cl- from internal acidic compartments. This alteration in the Cl- gradient brings about a positive shift in the reversal potential of the GABA-gated current, which can convert inhibitory synapses into excitatory synapses. Recently, we have shown that the cystic fibrosis transmembrane regulator …

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Pheromone-Trap Monitoring System For Pea Leaf Weevil, Sitona Lineatus: Effects Of Trap Type, Lure Type And Trap Placement Within Fields, Gadi V.P. Reddy, Govinda Shrestha, Debra A. Miller, A. Cameron Oehlschlager Jul 2018

Pheromone-Trap Monitoring System For Pea Leaf Weevil, Sitona Lineatus: Effects Of Trap Type, Lure Type And Trap Placement Within Fields, Gadi V.P. Reddy, Govinda Shrestha, Debra A. Miller, A. Cameron Oehlschlager

Faculty Publications

The pea leaf weevil, Sitona lineatus, is an important pest of field peas and faba beans worldwide. Present sampling techniques that rely on detection of adult feeding damage are labor intensive, time consuming and require repeated sampling. Semiochemical-based pest monitoring systems could improve pea leaf weevil management. This study, which was conducted in the Golden Triangle region of Montana, tested several factors that potentially might affect capture rates of pheromone-baited traps, including trap and lure type and trap placement. Pheromone-baited pitfall and ramp traps caught significantly more adults than ground or delta traps, in all study areas. Pitfall traps baited …

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Management Of Insect Pests In The Production And Storage Of Minor Pulses, Ruparao T. Gahukar, Gadi V.P. Reddy Jul 2018

Management Of Insect Pests In The Production And Storage Of Minor Pulses, Ruparao T. Gahukar, Gadi V.P. Reddy

Faculty Publications

Minor pulses are cultivated on a small scale by economically poor farming communities for subsistence food. Currently, these crops are under-utilized or neglected, although they are reasonable sources of protein and can increase food security in rural areas. Research and development is underway to improve the grain quality and increase the productivity of these crops, both of which are negatively impacted by insect pest damage. Synthetic pesticides have proven to be the most effective control agents against all pests of minor pulses which include sap sucking insects. However, considering the drawbacks of pesticide residues in the grain, environmental pollution, and …

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