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Deepdrug3d: Classification Of Ligand-Binding Pockets In Proteins With A Convolutional Neural Network, Limeng Pu, Rajiv Gandhi Govindaraj, Jeffrey Mitchell Lemoine, Hsiao Chun Wu, Michal Brylinski Feb 2019

Deepdrug3d: Classification Of Ligand-Binding Pockets In Proteins With A Convolutional Neural Network, Limeng Pu, Rajiv Gandhi Govindaraj, Jeffrey Mitchell Lemoine, Hsiao Chun Wu, Michal Brylinski

Faculty Publications

© 2019 Pu et al. Comprehensive characterization of ligand-binding sites is invaluable to infer molecular functions of hypothetical proteins, trace evolutionary relationships between proteins, engineer enzymes to achieve a desired substrate specificity, and develop drugs with improved selectivity profiles. These research efforts pose significant challenges owing to the fact that similar pockets are commonly observed across different folds, leading to the high degree of promiscuity of ligand-protein interactions at the system-level. On that account, novel algorithms to accurately classify binding sites are needed. Deep learning is attracting a significant attention due to its successful applications in a wide range of …

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Three Discipline Collaborative Radiation Therapy (3dcrt) Special Debate: The United States Should Build Additional Proton Therapy Facilities, Steve Braunstein, Li Wang, Wayne Newhauser, Todd Tenenholz, Yi Rong, Albert Van Der Kogel, Michael Dominello, Michael C. Joiner, Jay Burmeister Feb 2019

Three Discipline Collaborative Radiation Therapy (3dcrt) Special Debate: The United States Should Build Additional Proton Therapy Facilities, Steve Braunstein, Li Wang, Wayne Newhauser, Todd Tenenholz, Yi Rong, Albert Van Der Kogel, Michael Dominello, Michael C. Joiner, Jay Burmeister

Faculty Publications

No abstract provided.

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Radii Of 88 M Subdwarfs And Updated Radius Relations For Low-Metallicity M-Dwarf Stars, Aurora Y. Kesseli, J. Davy Kirkpatrick, Sergio B. Fajardo-Acosta, Matthew T. Penny, B. Scott Gaudi, Mark Veyette, Patricia C. Boeshaar, Calen B. Henderson, Michael C. Cushing, Sebastiano Calchi-Novati, Y. Shvartzvald, Philip S. Muirhead Feb 2019

Radii Of 88 M Subdwarfs And Updated Radius Relations For Low-Metallicity M-Dwarf Stars, Aurora Y. Kesseli, J. Davy Kirkpatrick, Sergio B. Fajardo-Acosta, Matthew T. Penny, B. Scott Gaudi, Mark Veyette, Patricia C. Boeshaar, Calen B. Henderson, Michael C. Cushing, Sebastiano Calchi-Novati, Y. Shvartzvald, Philip S. Muirhead

Faculty Publications

M subdwarfs are low-metallicity M dwarfs that typically inhabit the halo population of the Galaxy. Metallicity controls the opacity of stellar atmospheres; in metal-poor stars, hydrostatic equilibrium is reached at a smaller radius, leading to smaller radii for a given effective temperature. We compile a sample of 88 stars that span spectral classes K7 to M6 and include stars with metallicity classes from solar-metallicity dwarf stars to the lowest metallicity ultra subdwarfs to test how metallicity changes the stellar radius. We fit models to Palomar Double Spectrograph (DBSP) optical spectra to derive effective temperatures (T eff ) and we measure …

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Kmt-2017-Blg-0165lb: A Super-Neptune-Mass Planet Orbiting A Sun-Like Host Star, Youn Kil Jung, Andrew Gould, Weicheng Zang, Kyu Ha Hwang, Yoon Hyun Ryu, Cheongho Han, Jennifer C. Yee, Michael D. Albrow, Sun Ju Chung, In Gu Shin, Yossi Shvartzvald, Wei Zhu, Sang Mok Cha, Dong Jin Kim, Hyoun Woo Kim, Seung Lee Kim, Chung Uk Lee, Dong Joo Lee, Yongseok Lee, Byeong Gon Park, Richard W. Pogge, Matthew T. Penny, Shude Mao, Pascal Fouqué, Tianshu Wang Feb 2019

Kmt-2017-Blg-0165lb: A Super-Neptune-Mass Planet Orbiting A Sun-Like Host Star, Youn Kil Jung, Andrew Gould, Weicheng Zang, Kyu Ha Hwang, Yoon Hyun Ryu, Cheongho Han, Jennifer C. Yee, Michael D. Albrow, Sun Ju Chung, In Gu Shin, Yossi Shvartzvald, Wei Zhu, Sang Mok Cha, Dong Jin Kim, Hyoun Woo Kim, Seung Lee Kim, Chung Uk Lee, Dong Joo Lee, Yongseok Lee, Byeong Gon Park, Richard W. Pogge, Matthew T. Penny, Shude Mao, Pascal Fouqué, Tianshu Wang

Faculty Publications

We report the discovery of a low-mass-ratio planet (q = 1.3 × 10 -4 ), i.e., 2.5 times higher than the Neptune/Sun ratio. The planetary system was discovered from the analysis of the KMT-2017-BLG-0165 microlensing event, which has an obvious short-term deviation from the underlying light curve produced by the host of the planet. Although the fit improvement with the microlens parallax effect is relatively low, one component of the parallax vector is strongly constrained from the light curve, making it possible to narrow down the uncertainties of the lens physical properties. A Bayesian analysis yields that the planet has …

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Adiabatic Temperature Changes At Structural And Magnetic Phase Transitions In Ni45mn43cosn11 At High Magnetic Fields, Sudip Pandey, Yury Koshkid'ko, Igor Dubenko, Jacek Cwik, Anil Aryal, Alexander Granovsky, Erkki Lahderanta, Shane Stadler, Naushad Ali Feb 2019

Adiabatic Temperature Changes At Structural And Magnetic Phase Transitions In Ni45mn43cosn11 At High Magnetic Fields, Sudip Pandey, Yury Koshkid'ko, Igor Dubenko, Jacek Cwik, Anil Aryal, Alexander Granovsky, Erkki Lahderanta, Shane Stadler, Naushad Ali

Faculty Publications

The adiabatic temperature change (Δ Tad) in Ni45Mn43CoSn11 has been measured by a direct method in magnetic field changes up to 14 T. Large reversible magnetocaloric effects resulting in Δ Tad of about =-11 and 5 K have been observed for magnetic field changes of 14 T at the magnetostructural (TA ∼ 260 K) and magnetic transitions (TC ∼ 320 K), respectively. The impact of the thermomagnetic history on Δ Tad at high magnetic fields has been reported. The significant observed changes in the relaxation time of Δ Tad, depending on the type of the phase transitions, magnetization, and demagnetization …

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Effects Of Rare-Earth (R = Pr, Gd, Ho, Er) Doping On Magnetostructural Phase Transitions And Magnetocaloric Properties In Ni43-Xrxmn46sn11 Shape Memory Alloys, Anil Aryal, Sudip Pandey, Igor Dubenko, Dipanjan Mazumdar, Shane Stadler, Naushad Ali Feb 2019

Effects Of Rare-Earth (R = Pr, Gd, Ho, Er) Doping On Magnetostructural Phase Transitions And Magnetocaloric Properties In Ni43-Xrxmn46sn11 Shape Memory Alloys, Anil Aryal, Sudip Pandey, Igor Dubenko, Dipanjan Mazumdar, Shane Stadler, Naushad Ali

Faculty Publications

A series of rare-earth-doped Ni43-xRxMn46Sn11 (x= 0, 1 and R = Pr, Gd, Ho, Er) alloys was fabricated by arc melting, and their structural, magnetic, and magnetocaloric properties were studied through room temperature X-ray diffraction (XRD), differential scanning calorimetry, and magnetization measurements. Analysis of XRD data reveal that the alloys crystallize in the cubic L21 austenite phase structure as the major phase with a small trace of martensitic phase (MP). The martensitic transition temperature (TM) shifts to consecutive higher temperatures with the substitution of Pr, Gd, Ho, and Er. A drastic shift in TM by 60 K relative to the …

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Analysis Of The Angular Spectrum For Ultrashort Laser Pulses, Jeffrey M. Brown, Arnaud Couairon, Pavel Polynkin, Mette B. Gaarde Feb 2019

Analysis Of The Angular Spectrum For Ultrashort Laser Pulses, Jeffrey M. Brown, Arnaud Couairon, Pavel Polynkin, Mette B. Gaarde

Faculty Publications

We present a practical diagnostic for quantifying changes to the supercontinuum spectrum of an ultrashort laser pulse undergoing nonlinear propagation. The method allows a connection to be made between a nonlinear physics phenomenon and the specific regions of the angular spectrum that it affects. We apply this method to investigate interference between third-harmonic generation and self-phase modulation.

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Constraints On Neutrino Lifetime From The Sudbury Neutrino Observatory, B. Aharmim, S. N. Ahmed, A. E. Anthony, N. Barros, E. W. Beier, A. Bellerive, B. Beltran, M. Bergevin, S. D. Biller, R. Bonventre, K. Boudjemline, M. G. Boulay, B. Cai, E. J. Callaghan, J. Caravaca, Y. D. Chan, D. Chauhan, M. Chen, B. T. Cleveland, G. A. Cox, X. Dai, H. Deng, F. B. Descamps, J. A. Detwiler, P. J. Doe, G. Doucas, P. L. Drouin, M. Dunford Feb 2019

Constraints On Neutrino Lifetime From The Sudbury Neutrino Observatory, B. Aharmim, S. N. Ahmed, A. E. Anthony, N. Barros, E. W. Beier, A. Bellerive, B. Beltran, M. Bergevin, S. D. Biller, R. Bonventre, K. Boudjemline, M. G. Boulay, B. Cai, E. J. Callaghan, J. Caravaca, Y. D. Chan, D. Chauhan, M. Chen, B. T. Cleveland, G. A. Cox, X. Dai, H. Deng, F. B. Descamps, J. A. Detwiler, P. J. Doe, G. Doucas, P. L. Drouin, M. Dunford

Faculty Publications

The long baseline between Earth and the Sun makes solar neutrinos an excellent test beam for exploring possible neutrino decay. The signature of such decay would be an energy-dependent distortion of the traditional survival probability which can be fit for using well-developed and high-precision analysis methods. Here a model including neutrino decay is fit to all three phases of B8 solar neutrino data taken by the Sudbury Neutrino Observatory (SNO). This fit constrains the lifetime of neutrino mass state ν2 to be >8.08×10-5 s/eV at 90% confidence. An analysis combining this SNO result with those from other solar neutrino experiments …

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Trpm4 Ion Channels In Pre-Bötzinger Complex Interneurons Are Essential For Breathing Motor Pattern But Not Rhythm, Maria Cristina D. Picardo, Yae K. Sugimura, Kaitlyn E. Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam, Margaret S. Saha, Christopher A. Del Negro Feb 2019

Trpm4 Ion Channels In Pre-Bötzinger Complex Interneurons Are Essential For Breathing Motor Pattern But Not Rhythm, Maria Cristina D. Picardo, Yae K. Sugimura, Kaitlyn E. Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam, Margaret S. Saha, Christopher A. Del Negro

Faculty Publications

© 2019 Picardo et al. Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca 2+ )-activated nonselective cationic current (I CAN ) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing I CAN is predicted to slow down or stop breathing; its contributions to motor pattern would be reflected in the magnitude of movements (output). We tested the role(s) of I CAN using reverse genetic techniques to diminish its putative ion channels Trpm4 or Trpc3 in preBötC neurons in vivo. Adult mice transduced with Trpm4-targeted short hairpin RNA (shRNA) progressively decreased the tidal volume of …

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Bed Bugs (Cimex Lectularius L.) Exhibit Limited Ability To Develop Heat Resistance, Aaron R. Ashbrook, Michael E. Scharf, Gary W. Bennett, Ameya D. Gondhalekar Feb 2019

Bed Bugs (Cimex Lectularius L.) Exhibit Limited Ability To Develop Heat Resistance, Aaron R. Ashbrook, Michael E. Scharf, Gary W. Bennett, Ameya D. Gondhalekar

Faculty Publications

The global population growth of the bed bug, Cimex lectularius (L.), is attributed to their cryptic behavior, diverse insecticide resistance mechanisms, and lack of public awareness. Bed bug control can be challenging and typically requires chemical and non-chemical treatments. One common non-chemical method for bed bug management is thermal remediation. However, in certain instances, bed bugs are known to survive heat treatments. Bed bugs may be present after a heat treatment due to (i) abiotic factors associated with the inability to achieve lethal temperatures in harborage areas for a sufficient time period, (ii) re-infestation from insects that escaped to cooler …

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Combined Linkage And Association Analysis Identifies Rare And Low Frequency Variants For Blood Pressure At 1q31, Heming Wang, Priyanka Nandakumar, Fasil Tekola-Ayele, Bamidele O. Tayo, Erin B. Ware, C. Charles Gu, Yingchang Lu, Jie Yao, Wei Zhao, Jennifer A. Smith, Jacklyn N. Hellwege, Xiuqing Guo, Todd L. Edwards, Ruth J.F. Loos, Donna K. Arnett, Myriam Fornage, Charles Rotimi, Sharon L.R. Kardia, Richard S. Cooper, D. C. Rao, Georg Ehret, Aravinda Chakravarti, Xiaofeng Zhu Feb 2019

Combined Linkage And Association Analysis Identifies Rare And Low Frequency Variants For Blood Pressure At 1q31, Heming Wang, Priyanka Nandakumar, Fasil Tekola-Ayele, Bamidele O. Tayo, Erin B. Ware, C. Charles Gu, Yingchang Lu, Jie Yao, Wei Zhao, Jennifer A. Smith, Jacklyn N. Hellwege, Xiuqing Guo, Todd L. Edwards, Ruth J.F. Loos, Donna K. Arnett, Myriam Fornage, Charles Rotimi, Sharon L.R. Kardia, Richard S. Cooper, D. C. Rao, Georg Ehret, Aravinda Chakravarti, Xiaofeng Zhu

Faculty Publications

High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD) and is more prevalent in African Americans as compared to other US groups. Although large, population-based genome-wide association studies (GWAS) have identified over 300 common polymorphisms modulating inter-individual BP variation, largely in European ancestry subjects, most of them do not localize to regions previously identified through family-based linkage studies. This discrepancy has remained unexplained despite the statistical power differences between current GWAS and prior linkage studies. To address this issue, we performed genome-wide linkage analysis of BP traits in African-American families from the Family Blood Pressure Program …

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In Situ Geochemistry Of Middle Ordovician Dolomites Of The Upper Mississippi Valley, Achim D. Herrmann Feb 2019

In Situ Geochemistry Of Middle Ordovician Dolomites Of The Upper Mississippi Valley, Achim D. Herrmann

Faculty Publications

The dolomitization and diagenetic history of Ordovician carbonates of southern Wisconsin is complex. Previous studies attributed dolomitization to various diagenetic factors and environments. In this study, high-resolution, in situ laser ablation inductively coupled mass spectrometry analysis of rare earth element patterns of dolomite was used to assess the diagenetic fluids responsible for dolomitization of the Ordovician Decorah Formation. Integrated geochemical data and petrographic evidence suggest that the dolostones are formed in two different diagenetic realms: shallow burial and hydrothermal. Shallow burial dolomites exhibit three distinct rare earth element patterns. Dolomite from the middle portion of the Guttenberg Member exhibits light …

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Host Sex, Size, And Hemoparasite Infection Influence The Effects Of Ectoparasitic Burdens On Free-Ranging Iguanas, Christine Lattin Feb 2019

Host Sex, Size, And Hemoparasite Infection Influence The Effects Of Ectoparasitic Burdens On Free-Ranging Iguanas, Christine Lattin

Faculty Publications

Investigations focusing on host-ectoparasite interactions in animals have revealed asymptomatic to severe health and fitness consequences suggesting that species mobilize different interspecific response mechanisms. Fewer studies, however, have examined intraspecific responses to ectoparasitic burdens. In this study, we analyzed host health and fitness responses to increasing ectoparasite burdens along with the presence/absence of hemoparasites of free-ranging insular rock iguanas (Cyclura cychlura) in The Bahamas. Using hematology, plasma biochemistry, as well as body condition and growth rate comparisons, we failed to find significant associations of tick burdens with annual growth rate, corticosterone, packed cell volume, total white blood cell, and heterophil, …

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Impacts Of Elevated Pco2 On Estuarine Phytoplankton Biomass And Community Structure In Two Biogeochemically Distinct Systems In Louisiana, Usa, Amy J. Mallozzi, Reagan M. Errera, Sibel Bargu, Achim D. Herrmann Feb 2019

Impacts Of Elevated Pco2 On Estuarine Phytoplankton Biomass And Community Structure In Two Biogeochemically Distinct Systems In Louisiana, Usa, Amy J. Mallozzi, Reagan M. Errera, Sibel Bargu, Achim D. Herrmann

Faculty Publications

© 2018 Ocean acidification has the potential to impact the ocean's biogeochemical cycles and food web dynamics, with phytoplankton in the distinctive position to profoundly influence both, as individual phytoplankton species play unique roles in energy flow and element cycling. Previous studies have focused on short-term exposure of monocultures to low pH, but do not reflect the competitive dynamics within natural phytoplankton communities. This study explores the use of experimental microcosms to expose phytoplankton assemblages to elevated pCO2 for an extended period of time. Phytoplankton communities were collected from two biogeochemically distinct Louisiana estuaries, Caillou Lake (CL) and Barataria Bay …

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Review Of The Altruists, Michael F. Russo Feb 2019

Review Of The Altruists, Michael F. Russo

Faculty Publications

A book review of the debut novel by Andrew Ridker.

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Workshop Report: Cryopreservation Of Aquatic Biomedical Models, Mary Hagedorn, Zoltan Varga, Ronald B. Walter, Terrence R. Tiersch Feb 2019

Workshop Report: Cryopreservation Of Aquatic Biomedical Models, Mary Hagedorn, Zoltan Varga, Ronald B. Walter, Terrence R. Tiersch

Faculty Publications

The genetic resources of aquatic biomedical model organisms are the products of millions of years of evolution, decades of scientific development, and hundreds of millions of dollars of research funding investment. Genetic resources (e.g., specific alleles, transgenes, or combinations) of each model organism can be considered a form of scientific wealth that can be accumulated and exchanged, typically in the form of live animals or germplasm. Large-scale maintenance of live aquatic organisms that carry these genetic resources is inefficient, costly, and risky. In situ maintenance may be substantially enhanced and backed up by combining cryopreserved germplasm repositories and genetic information …

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Gobbling Chronology Of Eastern Wild Turkeys In South Carolina, Patrick H. Wightman, John C. Kilgo, Mark Vukovich, Jay R. Cantrell, Charles R. Ruth, Bradley S. Cohen, Michael J. Chamberlain, Bret A. Collier Feb 2019

Gobbling Chronology Of Eastern Wild Turkeys In South Carolina, Patrick H. Wightman, John C. Kilgo, Mark Vukovich, Jay R. Cantrell, Charles R. Ruth, Bradley S. Cohen, Michael J. Chamberlain, Bret A. Collier

Faculty Publications

Eastern wild turkeys (Meleagris gallopavo silvestris) use a polygynous-promiscuous mating system, wherein males compete for mating opportunities and communicate with females via courtship behaviors. One courtship behavior is vocalization (gobbling), which attracts females and signals dominance to other males. However, temporal variation in gobbling activity may be influenced by external stimuli, environmental variation, and hunter activity. Gobbling activity is a key determinant of hunter satisfaction, and gobbling chronology is often used by state agencies to inform regulatory processes. To identify factors influencing gobbling activity, we evaluated daily gobbling chronology on 3 sites in South Carolina, USA (Webb Wildlife Management Area …

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Effect Of Fertilization On Anatomical And Physical-Mechanical Properties Of Neosinocalamus Affinis Bamboo, Jiulong Xie, Jinqiu Qi, Hongling Hu, Cornelis F. De Hoop, Hui Xiao, Yuzhu Chen, Chungyun Hse Feb 2019

Effect Of Fertilization On Anatomical And Physical-Mechanical Properties Of Neosinocalamus Affinis Bamboo, Jiulong Xie, Jinqiu Qi, Hongling Hu, Cornelis F. De Hoop, Hui Xiao, Yuzhu Chen, Chungyun Hse

Faculty Publications

In order to maintain soil fertility of Neosinocalamus affinis plantations, fertilizers of N, P, and K were applied. The anatomical and physical-mechanical properties of N. affinis bamboo wood from different fertilization treatments were measured. The aim of this study was to elucidate the effect of fertilization practice on the properties of N. affinis bamboo wood. The results revealed that the fertilization of P and K resulted in a slight reduction in fiber length. The application of P, K, and low level (0.3 kg/clump) of N fertilizers had no significant effect on the fiber morphology, while high level (0.9 kg/clump) of …

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Distress Tolerance And Cannabis Craving: The Impact Of Laboratory-Induced Distress, Julia D. Buckner, Katherine Walukevich Dienst, Michael J. Zvolensky Feb 2019

Distress Tolerance And Cannabis Craving: The Impact Of Laboratory-Induced Distress, Julia D. Buckner, Katherine Walukevich Dienst, Michael J. Zvolensky

Faculty Publications

Low levels of distress tolerance have been identified as an important vulnerability factor for negative cannabis outcomes. The current study is the first known experimental manipulation of state distress to test whether distress tolerance interacts with state distress to predict the urge to use cannabis. Current cannabis users (N = 126; 88.9% with cannabis use disorder; 54.0% non-Hispanic Caucasian) were randomly assigned to a distress task condition or neutral (reading) task condition. Participants in the 2 conditions did not differ on distress tolerance, negative affect (NA), or craving at baseline. The distress tolerance X condition interaction significantly predicted task NA, …

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Meta-Analysis Of Quantitative Trait Loci Associated With Seedling-Stage Salt Tolerance In Rice (Oryza Sativa L.), Md Shofiqul Islam, John Ontoy, Prasanta K. Subudhi Feb 2019

Meta-Analysis Of Quantitative Trait Loci Associated With Seedling-Stage Salt Tolerance In Rice (Oryza Sativa L.), Md Shofiqul Islam, John Ontoy, Prasanta K. Subudhi

Faculty Publications

Soil and water salinity is one of the major abiotic stresses that reduce growth and productivity in major food crops including rice. The lack of congruence of salt tolerance quantitative trait loci (QTLs) in multiple genetic backgrounds and multiple environments is a major hindrance for undertaking marker-assisted selection (MAS). A genome-wide meta-analysis of QTLs controlling seedling-stage salt tolerance was conducted in rice using QTL information from 12 studies. Using a consensus map, 11 meta-QTLs for three traits with smaller confidence intervals were localized on chromosomes 1 and 2. The phenotypic variance of 3 meta-QTLs was _20%. Based on phenotyping of …

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Metal Levels In Whales From The Gulf Of Maine: A One Environmental Health Approach, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Cairong Zhu, Cynthia L. Browning, Tongzhang Zheng, Christopher Perkins, Christy Gianios, Hong Xie, John Pierce Wise Feb 2019

Metal Levels In Whales From The Gulf Of Maine: A One Environmental Health Approach, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Cairong Zhu, Cynthia L. Browning, Tongzhang Zheng, Christopher Perkins, Christy Gianios, Hong Xie, John Pierce Wise

Faculty Publications

One Environmental Health has emerged as an important area of research that considers the interconnectedness of human, animal and ecosystem health with a focus on toxicology. The great whales in the Gulf of Maine are important species for ecosystem health, for the economies of the Eastern seaboard of the United States, and as sentinels for human health. The Gulf of Maine is an area with heavy coastal development, industry, and marine traffic, all of which contribute chronic exposures to environmental chemicals that can bioaccumulate in tissues and may gradually diminish an individual whale's or a population's fitness. We biopsied whales …

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Purification, Identification, And Sensory Evaluation Of Kokumi Peptides From Agaricus Bisporus Mushroom, Tao Feng, Yang Wu, Zhiwen Zhang, Shiqing Song, Haining Zhuang, Zhimin Xu, Linyun Yao, Min Sun Feb 2019

Purification, Identification, And Sensory Evaluation Of Kokumi Peptides From Agaricus Bisporus Mushroom, Tao Feng, Yang Wu, Zhiwen Zhang, Shiqing Song, Haining Zhuang, Zhimin Xu, Linyun Yao, Min Sun

Faculty Publications

Agaricus bisporus can enhance the umami and salty taste in chicken soup, and also has a high protein content, which indicates that there might be some kokumi taste compounds in this mushroom. Therefore, through ultrafiltration, gel permeation chromatography (GPC), and reverse phase-high performance liquid chromatography (RP-HPLC), some peptides in fresh Agaricus bisporus mushroom were isolated. Then, these peptides were identified by sensory evaluation and ultra performance liquid chromatography (UPLC) coupled quadruple time of flight mass spectrometry (Q-TOF-MS). The sensory evaluation results showed that the addition of aqueous extract isolated from Agaricus bisporus to model chicken broth did enhance chicken broth's …

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B Cell Homeostasis Is Maintained During Long-Duration Spaceflight, Guillaume Spielmann, Nadia Agha, Hawley Kunz, Richard J. Simpson, Brian Crucian, Satish Mehta, Mitzi Laughlin, John Campbell Feb 2019

B Cell Homeostasis Is Maintained During Long-Duration Spaceflight, Guillaume Spielmann, Nadia Agha, Hawley Kunz, Richard J. Simpson, Brian Crucian, Satish Mehta, Mitzi Laughlin, John Campbell

Faculty Publications

Long-duration spaceflights reportedly induce immune dysregulation, which is considered a risk to astronaut safety and mission success. Recent studies have examined the impact of spaceflight on markers of adaptive and innate immunity, but no study, to date, has comprehensively evaluated humoral immunity and serological markers of B cell function. The aim of this study was to characterize changes in B cell numbers and phenotypes, along with plasma Igs and polyclonal free light chains (FLCs)—near-“real-time” biomarkers of Ig synthesis—in response to an ~6-mo mission to the International Space Station (ISS). Whole-blood samples were collected before flight, during flight (“Early flight,” “Mid-flight,” …

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More Than A Pretty Interface: The Louisiana Digital Library As A Data Hub, Sl Ziegler Feb 2019

More Than A Pretty Interface: The Louisiana Digital Library As A Data Hub, Sl Ziegler

Faculty Publications

The Louisiana Digital Library (LDL) is an online platform for libraries, museums, archives, and historical organizations across the state. The books, manuscripts, oral histories, maps, and photographs held in the LDL showcase the cultural resources of Louisiana. The interface enables users to discover materials through search and browse, and to view and interact with these materials. The metadata about these items is also a great asset. When explored in their entirety, the data held in the LDL is as valuable as the digital facsimiles. The LDL may be conceptualized as a data hub, a place to gather and share the …

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Politics And Entrepreneurship In The Us, Louis Philippe Beland, Bulent Unel Feb 2019

Politics And Entrepreneurship In The Us, Louis Philippe Beland, Bulent Unel

Faculty Publications

There is a strong belief that Republicans are more pro-business than Democrats. In this paper, we investigate the causal impact of partisan allegiance of governors (Republican or Democratic) on entrepreneurial activity by exploiting random variation in close gubernatorial elections in 50 states over the last three decades in a regression discontinuity design. We find that Republican governors are no different than Democratic governors in their effects on entrepreneurship. Our findings are robust to several sensitivity checks.

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Prediction Of Ice-Free Conditions For A Perennially Ice-Covered Antarctic Lake, M. K. Obryk, P. T. Doran, J. C. Priscu Feb 2019

Prediction Of Ice-Free Conditions For A Perennially Ice-Covered Antarctic Lake, M. K. Obryk, P. T. Doran, J. C. Priscu

Faculty Publications

©2019. American Geophysical Union. All Rights Reserved. Although perennially ice-covered Antarctic lakes have experienced variable ice thicknesses over the past several decades, future ice thickness trends and associated aquatic biological responses under projected global warming remain unknown. Heat stored in the water column in chemically stratified Antarctic lakes that have middepth temperature maxima can significantly influence the ice thickness trends via upward heat flux to the ice/water interface. We modeled the ice thickness of the west lobe of Lake Bonney, Antarctica, based on possible future climate scenarios utilizing a 1D thermodynamic model that accounts for surface radiative fluxes as well …

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Effect Of Heat Treatments On Pore Morphology And Microstructure Of Laser Additive Manufactured Parts, Bin Zhang, Wen Jin Meng, Shuai Shao, Nam Phan, Nima Shamsaei Feb 2019

Effect Of Heat Treatments On Pore Morphology And Microstructure Of Laser Additive Manufactured Parts, Bin Zhang, Wen Jin Meng, Shuai Shao, Nam Phan, Nima Shamsaei

Faculty Publications

The slit-shaped, lack-of-fusion pores (LFPs) persistent in the additively manufactured (AM) metals are detrimental to their fatigue resistance due to the associated stress concentrations at the edges. Postbuild treatments, such as hot isostatic pressing (HIP), are routinely used to eliminate pores resulting in, however, inconsistent improvements in fatigue performance. This work critically examines the effectiveness of HIP to eliminate such pores in AM Ti-6Al-4V. In addition, conventional heat treatment (HT) is proposed as a candidate remedial process to alleviate the harmful effects of the LFPs. Specifically, the spheroidization effect of HT on the sharp edges of the LFPs is investigated. …

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Performance And Characterization Of Dynamically-Loaded Engine Bearings With Provision For Misalignment, J. Y. Jang, M. M. Khonsari Feb 2019

Performance And Characterization Of Dynamically-Loaded Engine Bearings With Provision For Misalignment, J. Y. Jang, M. M. Khonsari

Faculty Publications

The influence of misalignment on a dynamically-loaded engine bearing is investigated using a mass-conserving cavitation algorithm. Whereas in statically loaded bearings misalignment can be conveniently characterized using two parameters known as the degree of misalignment DM and the misalignment angle α an alternative approach is needed when the load changes direction. In this paper, the complication is treated by representing the severity of misalignment using two deflection angles θx and θy since these deflection angles remain constant in an engine bearing during operation. Effects of the variation of load, rotating speed, oil viscosity, supply pressure, journal mass and deflection angles …

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3d Macroporous Zinc Compound/Silicone Hybrid Foams For Amperometric Sensing Of Glucose Oxidase, Ye Wu, Hao Fu, Weiwei Xie, Yingcheng Lin, Orhan Kizilkaya, Jian Xu Feb 2019

3d Macroporous Zinc Compound/Silicone Hybrid Foams For Amperometric Sensing Of Glucose Oxidase, Ye Wu, Hao Fu, Weiwei Xie, Yingcheng Lin, Orhan Kizilkaya, Jian Xu

Faculty Publications

A 3D porous matrix makes an intriguing sensing platform, which can integrate functional guest molecules. Here, the first demonstration of a zinc compound/silicone hybrid foam is reported for amperometric sensing of glucose oxidase. The silicone foam is fabricated by a self-developed solid-filling-melting method. Two zinc-based polymers, Zn-Compound-1 and Zn-Compound-2, are synthesized. Zn-Compound-1 and Zn-Compound-2 are characterized by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, Raman spectroscopy, and X-ray absorption nearedge structure spectroscopy of carbon K-edge, oxygen K-edge, and zinc L-edge. Effective amperometric sensing of glucose oxidase is achieved by introducing Zn-Compound-1 or Zn-Compound-2 into the silicone foam, i.e., an …

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Constrained Vcg Auction With Multi-Level Channel Valuations For Spatial Spectrum Reuse In Non-Symmetric Networks, Feixiang Zhang, Xiangwei Zhou, Mingxuan Sun Feb 2019

Constrained Vcg Auction With Multi-Level Channel Valuations For Spatial Spectrum Reuse In Non-Symmetric Networks, Feixiang Zhang, Xiangwei Zhou, Mingxuan Sun

Faculty Publications

Spatial spectrum reuse enables better utilization of limited spectral resources to achieve higher system throughput. However, improving the system throughput or spectrum efficiency does not necessarily translate to the satisfaction of more secondary users (SUs) according to their demands. To improve user satisfaction, user characteristics involving the supply and demand relationship need to be considered and thus enable heterogeneous channel valuations in spatial spectrum reuse. In this paper, we design a channel transaction mechanism for non-symmetric networks and maximize user satisfaction in consideration of multi-level flexible channel valuations of the SUs. Specifically, we introduce a Vickrey-Clarke-Groves (VCG) auction, in which …

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