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Articles 391 - 420 of 23433
Full-Text Articles in Entire DC Network
Global Ocean Bottom Temperature Observation Design: Observing System Simulation Experiments For Strategic Deployment Of Smart Subsea Cables, Karen E. Renninger-Rojas
Global Ocean Bottom Temperature Observation Design: Observing System Simulation Experiments For Strategic Deployment Of Smart Subsea Cables, Karen E. Renninger-Rojas
LSU Master's Theses
Deep-ocean observations below 2000 meters remain limited, restricting our ability to model global ocean processes critical to climate prediction. This thesis evaluates the potential of SMART (Science Monitoring and Reliable Telecommunications) subsea cables to address these observational gaps by conducting Observing System Simulation Experiments (OSSEs) and adjoint sensitivity analyses using the MITgcm ocean model and ECCO outputs.
Vertical decorrelation analysis showed that temperature and salinity in key regions decouple from the upper ocean beyond 2000 m. Over 60% of the proposed SMART cable sites exhibited decorrelation depths exceeding Argo’s maximum sampling depth, highlighting their strategic value for deployment.
A comparison …
Animal-Assisted Therapy With Children In Hospitals And Schools: A Systematized Review, Tantine Kendig
Animal-Assisted Therapy With Children In Hospitals And Schools: A Systematized Review, Tantine Kendig
LSU Master's Theses
It has been demonstrated that animals can offer humans significant health benefits. Animal-assisted therapy (AAT) is a growing form of therapy used in various settings to enhance the health of children, encompassing both physical and mental wellness. The challenges of hospitalization and the school environment have been shown to pose different challenges for children, such as an increase in anxiety, stress, depression, and others that have the potential to affect their mental, physical, emotional, and social well-being. This study aimed to assess the effectiveness of animal-assisted therapy, specifically dog-assisted therapy, on children in hospital and school settings by conducting a …
Impacts Of Extreme Weather Conditions On Coastal Fisheries Near Bayou Teche, Louisiana From 2019–2023, Georgia C. Davis
Impacts Of Extreme Weather Conditions On Coastal Fisheries Near Bayou Teche, Louisiana From 2019–2023, Georgia C. Davis
LSU Master's Theses
The region of Southcentral Louisiana, particularly around Bayou Teche, thrives on its commercial and recreational fisheries. These fisheries are occasionally subject to events like extreme weather that cause sudden and unexpected losses (NOAA Fisheries, 2024a). Between 2019 and 2023, a series of extreme weather events impacted southcentral Louisiana near Bayou Teche. This series of extreme events includes Hurricane Barry (2019), Hurricane Laura (2020), Hurricane Delta (2020), Hurricane Zeta (2020), Hurricane Ida (2021), and a United States Drought Monitor (USDM) D4 drought (2023). This study analyzes the impacts of the extreme weather series on coastal fish observed species richness (SR) in …
Multiparticle Quantum Plasmonics: Fundamentals And Applications, Mingyuan Hong
Multiparticle Quantum Plasmonics: Fundamentals And Applications, Mingyuan Hong
LSU Doctoral Dissertations
Quantum plasmonics explores the interaction between light and collective charge oscillations at metal-dielectric interfaces, enabling strong light confinement and enhanced quantum effects at the nanoscale. While traditional quantum optics has primarily focused on single-photon systems, an intermediate regime exists between classical and single-photon optics - multiparticle (or multiphoton) quantum optics. In this regime, classical light sources, when analyzed through techniques such as photon-number-resolving (PNR) detection and projective measurement, can reveal nontrivial quantum correlations. This thesis investigates how multiparticle quantum plasmonics harnesses these correlations to control quantum statistical properties, enhance coherence, and enable novel applications in quantum technologies.
In this thesis, …
Decadal To Millennial-Scale Morphodynamic Evolution Of Microtidal Marshes, Samuel Mason Zapp
Decadal To Millennial-Scale Morphodynamic Evolution Of Microtidal Marshes, Samuel Mason Zapp
LSU Doctoral Dissertations
Tidal marshes are susceptible to rapidly converting to open water due to their low elevations within the tidal frame. A continuous supply of externally supplied mineral sediment and in situ organic material production is necessary to offset elevation losses from relative sea level rise and erosion. Complex feedbacks between hydrodynamics, the erosion, transport, and deposition of sediment, and physical modification of the landscape by the establishment of intertidal vegetation govern the spatial and temporal patterns of elevation response. This dissertation focuses on modeling how these dynamics drive marsh landscape evolution in the past, present, and into the future under changing …
Neuronal Cftr: A Study Of Subcellular Localization And Interactions With Implications For A Role In Synaptic Transmission, Brandon J. Leviskas
Neuronal Cftr: A Study Of Subcellular Localization And Interactions With Implications For A Role In Synaptic Transmission, Brandon J. Leviskas
LSU Doctoral Dissertations
Protein-protein interactions vary among cell types and the localization of these interactions help to define protein function. The function of cystic fibrosis transmembrane conductance regulator (CFTR) is well established in the context of epithelial tissue due to the debilitating effects of its mutations that cause the disease cystic fibrosis. While in neurons a role has been established in our lab for CFTR in the regulation of cytosolic Cl- in retinal amacrine cells (ACs). This research sets out to learn if CFTR has a synaptic role. Exploring this potential role, localization of CFTR was examined using fluorescent and immunogold labeled transmission …
Ligo Detector Characterization In The First Half Of The Fourth Observing Run, S. Soni, B. K. Berger, D. Davis, F. Di Renzo, A. Effler, T. A. Ferreira, J. Glanzer, E. Goetz, G. González, A. Helmling-Cornell, B. Hughey, R. Huxford, B. Mannix, G. Mo, D. Nandi, A. Neunzert, S. Nichols, K. Pham, A. I. Renzini, R. M.S. Schofield, A. Stuver, M. Trevor, S. Álvarez-López, R. Beda, C. P.L. Berry, S. Bhuiyan, L. Blagg, R. Bruntz, S. Callos, M. Chan, P. Charlton, N. Christensen, G. Connolly
Ligo Detector Characterization In The First Half Of The Fourth Observing Run, S. Soni, B. K. Berger, D. Davis, F. Di Renzo, A. Effler, T. A. Ferreira, J. Glanzer, E. Goetz, G. González, A. Helmling-Cornell, B. Hughey, R. Huxford, B. Mannix, G. Mo, D. Nandi, A. Neunzert, S. Nichols, K. Pham, A. I. Renzini, R. M.S. Schofield, A. Stuver, M. Trevor, S. Álvarez-López, R. Beda, C. P.L. Berry, S. Bhuiyan, L. Blagg, R. Bruntz, S. Callos, M. Chan, P. Charlton, N. Christensen, G. Connolly
Faculty Publications
Progress in gravitational-wave (GW) astronomy depends upon having sensitive detectors with good data quality. Since the end of the Laser Interferometer Gravitational-Wave Observatory-Virgo-KAGRA third Observing run in March 2020, detector-characterization efforts have lead to increased sensitivity of the detectors, swifter validation of GW candidates and improved tools used for data-quality products. In this article, we discuss these efforts in detail and their impact on our ability to detect and study GWs. These include the multiple instrumental investigations that led to reduction in transient noise, along with the work to improve software tools used to examine the detectors data-quality. We end …
Disorder Enhanced Thermalization In Interacting Many-Particle System, Chakradhar Rangi, Herbert F. Fotso, Hanna Terletska, Juana Moreno, Ka Ming Tam
Disorder Enhanced Thermalization In Interacting Many-Particle System, Chakradhar Rangi, Herbert F. Fotso, Hanna Terletska, Juana Moreno, Ka Ming Tam
Faculty Publications
We introduce an extension of the nonequilibrium dynamical mean-field theory to incorporate the effects of static random disorder in the dynamics of a many-particle system by integrating out different disorder configurations resulting in an effective time-dependent density-density interaction. We use this method to study the nonequilibrium transient dynamics of a system described by the Fermi Anderson-Hubbard model following an interaction and disorder quench. The method recovers the solution of the disorder-free case for which the system exhibits qualitatively distinct dynamical behaviors in the weak-coupling (prethermalization) and strong-coupling regimes (collapse-and-revival oscillations). However, we find that weak random disorder promotes thermalization. In …
Disentanglement In Representation Learning: Interpretability In Dimension Reduction With Vae, Minh Hong Vu
Disentanglement In Representation Learning: Interpretability In Dimension Reduction With Vae, Minh Hong Vu
LSU Doctoral Dissertations
This research explores both theoretical and practical aspects of disentangled representation learning by extending the VAE framework. We address the core challenge of extracting independent generative factors from observed data while preserving high reconstruction fidelity. To this end, we propose two novel VAE variants: (i) the $\lambda\beta$-VAE, which incorporates an additional $\ell^2$-norm reconstruction loss to improve accuracy, and (ii) the $\gamma\beta$-VAE, which introduces a mutual information regularization term to encourage independence across latent dimensions.
Our theoretical analysis is conducted in a linear Gaussian setting, where we derive optimal solutions for these VAE-based models. We further examine how varying levels of …
Ai-Based Accessibility Widget (Aibaw) Shortcomings For Blind Web Users, Joshua A. Rovira
Ai-Based Accessibility Widget (Aibaw) Shortcomings For Blind Web Users, Joshua A. Rovira
LSU Master's Theses
With legal, ethical, and financial motivations to make their websites more accessible, many businesses and sites have begun to employ the use of artificial intelligence (AI) based widgets to automatically make necessary modifications to their sites' pages and subdomains. In this work, we conduct a qualitative case study to determine the efficacy of these AI tools as they pertain specifically to blind users. We analyze pages from twelve websites using accessiBe's AI accessibility widget and provide a taxonomy of their violations against the Web Content Accessibility Guidelines (WCAG) 2.1 level AA compliance. We found each website to bear numerous violations …
My Tunisia Encounters: Inspiration For Some Mathematical Ideas, Hui-Hsiung Kuo
My Tunisia Encounters: Inspiration For Some Mathematical Ideas, Hui-Hsiung Kuo
Journal of Stochastic Analysis
No abstract provided.
Wind-Resilient Solar: Harnessing Cfd For Enhanced Load Estimation, Aly Mousaad Aly
Wind-Resilient Solar: Harnessing Cfd For Enhanced Load Estimation, Aly Mousaad Aly
Faculty Publications
Solar panels are a cornerstone of renewable energy infrastructure, playing a pivotal role in global sustainability efforts. To ensure their resilience and long-term viability, accurate wind load estimations are essential for designing supporting structures, which account for nearly 50% of their total cost. However, traditional building codes lack comprehensive guidance for solar panels, resulting in inconsistent estimations due to discrepancies in scaled wall-bounded wind tunnel testing methodologies. These inaccuracies pose safety risks, increase costs, and hinder adoption. Emerging technologies like computational fluid dynamics (CFD) simulations offer a promising alternative by enabling full-scale analysis under realistic conditions of complete turbulence. This …
The Impact Of Visual Stimuli And The Properties Of Green Walls On Human Well-Being In Built And Immersive Virtual Environments, Alireza Sedghikhanshir
The Impact Of Visual Stimuli And The Properties Of Green Walls On Human Well-Being In Built And Immersive Virtual Environments, Alireza Sedghikhanshir
LSU Doctoral Dissertations
The built environment significantly influences human well-being, particularly in the context of stress recovery and cognitive restoration. This dissertation investigates the impact of visual stimuli, particularly green walls, on human responses related to stress, restoration, and thermal comfort. The research is guided by three primary objectives: (1) examining the role of visual stimuli and their properties in promoting stress recovery and restoration, (2) evaluating the potential of Immersive Virtual Environments (IVEs) as tools for delivering and studying restorative environments, and (3) investigating the influence of green walls on indoor environmental conditions.
A series of experimental studies were carried out to …
Intraspecific Variation In Morphological And Biochemical Responses To Salinity And Flooding In Phragmites Australis, Olivia Hurley
Intraspecific Variation In Morphological And Biochemical Responses To Salinity And Flooding In Phragmites Australis, Olivia Hurley
LSU Master's Theses
Phragmites australis is a widespread wetland plant species with numerous haplotypes, several of which are highly invasive. In low-lying coastal marshes of Louisiana, the Delta-type (haplotype M1) dominates across a wide range of salinity and flooding environments. This suggests that Phragmites may be highly adaptable to diverse environmental conditions and that there may be a genetic component, as seen in other coastal wetland plant species. While non-native Phragmites haplotypes are targeted for control and removal in many areas, they are considered beneficial for marsh stabilization and contributing to elevation gain in coastal Louisiana, where several areas experience rapid land loss. …
Optimizing Llm X86 Assembly Code Comprehension Through Fine-Tuning, Darrin Michael Lea
Optimizing Llm X86 Assembly Code Comprehension Through Fine-Tuning, Darrin Michael Lea
LSU Master's Theses
Reverse engineering is a cybersecurity process that focuses on understanding the underlying functionality of software or malware. This is an arduous process that demands large amounts of time and effort from cybersecurity practitioners. Large Language Models (LLMs) offer a potential solution to this problem. LLMs have worked their way into various fields of cybersecurity in recent years, including incident response and malware classification. However, LLMs have historically struggled with low-level code comprehension: a necessary part of reverse engineering. While LLMs can generate code and explain its function on the surface level, they struggle to grasp the wider context. In this …
Growing The Good: A Communal Garden Case Study Among Marginalized, Rural Populations, Claire Barbier
Growing The Good: A Communal Garden Case Study Among Marginalized, Rural Populations, Claire Barbier
LSU Master's Theses
Community and Communal gardens (CG) have been documented as early as the late 1800s during periods of economic recessions and high food insecurity (The MIT Press Reader, 2022). However, C.G. adoption rates are expanding on a global scale as communities and municipalities see the potential for the tool to bring relief to environments in dire need of additional resources. Utilizing a communal garden can be used to address a surplus of systemic barriers a community faces; it has a significant opportunity to bring forth the interconnected tiers of public health altogether (Twiss et. al, 2003). Modernized C.G projects bring forth …
Exploring The Impact Of Social Media And Social Networks On Juvenile Sexual Behavior Problems: A Scoping Review, Shaleen Clay
Exploring The Impact Of Social Media And Social Networks On Juvenile Sexual Behavior Problems: A Scoping Review, Shaleen Clay
LSU Master's Theses
The issue of juvenile problematic sexual behavior has become a pervasive problem, and little research exists on the topic. How social media and social networks impact problematic sexual behaviors in juveniles is even less known and understood. The objective of this scoping review was to determine what is known about the impact of social media and social networks on juvenile sexual behavior problems. Four key themes appeared in the literature including the use of adult terminology, rather than juvenile, to describe juvenile relationships; the normalization of abusive behaviors within adolescent relationship; the influence of social networks/peer groups on aggression and …
Unfitted Finite Element Methods For Shape Optimization And Liquid Crystals, Jeremy T. Shahan
Unfitted Finite Element Methods For Shape Optimization And Liquid Crystals, Jeremy T. Shahan
LSU Doctoral Dissertations
We present an approach to shape optimization problems that uses an unfitted finite element method (FEM). The domain geometry is represented, and optimized, using a (dis- crete) level set function and we consider objective functionals that are defined over bulk domains. For a discrete objective functional, defined in the unfitted FEM framework, we show that the exact discrete shape derivative essentially matches the shape derivative at the continuous level. In other words, our approach has the benefits of both optimize-then- discretize and discretize-then-optimize approaches.
Specifically, we establish the shape Fréchet differentiability of discrete (unfitted) bulk shape functionals using both the …
Innovative Design Methodology For Durable Open-Graded Friction Course Asphalt Mixtures, Anas Abualia
Innovative Design Methodology For Durable Open-Graded Friction Course Asphalt Mixtures, Anas Abualia
LSU Doctoral Dissertations
Open-graded friction course (OGFC) is a thin asphalt mixture surface layer with a high percentage of coarse aggregates and high interconnected air voids, which provides improved skid resistance, visibility, and decreased pavement-tire noise. However, construction personnel at DOTD reported that conventional OGFC mixtures have short service life (raveling distress). Further, their structural contribution to the pavement structure is commonly neglected and designed only for functionality purposes.
The objective of this study was to develop a rational mix design methodology to improve the durability of OGFC asphalt mixtures. Specific objectives are to: (1) conduct a rheological and chemical characterization of polymer-, …
“They Love Our Rhythm, But Not Our Blues:” An Examination Of The Relationship Between Hip Hop On Depression, Anxiety, And Self-Care Among African American And Hispanic/Latinx Emerging Adults, Richard W. Wiley Jr.
“They Love Our Rhythm, But Not Our Blues:” An Examination Of The Relationship Between Hip Hop On Depression, Anxiety, And Self-Care Among African American And Hispanic/Latinx Emerging Adults, Richard W. Wiley Jr.
LSU Doctoral Dissertations
Depression and anxiety are among the most common mental health problems for emerging adults of color in higher education. Specifically, African American/Black and Hispanic/Latinx emerging adults on college campuses have poorer mental health than their White counterparts. Considering the systemic oppression and cultural stressors that impact mental health among African American/Black and Hispanic/Latinx students, Critical Race Theory (CRT) and Emerging Adulthood Theory were theoretical frameworks for this study. The purpose of this study was to examine the relationship between Hip Hop music and depression, anxiety, and intentional use as self-care among African American/Black and Hispanic/Latinx emerging adults who were college …
Modeling And Simulation Of Methane And Co2 Hydrates In Porous Media, Chico Sambo
Modeling And Simulation Of Methane And Co2 Hydrates In Porous Media, Chico Sambo
LSU Doctoral Dissertations
This dissertation presents a comprehensive study on modeling and simulation for
methane hydrate production and CO2 sequestration. The research focuses on pore-
scale and reservoir-scale modeling techniques to understand the dynamics of gas
hydrate dissociation, the associated risks of subsidence, and the potential for CO2
storage in deep-sea environments.
This dissertation begins with an investigation into pore-scale modeling. Specif-
ically, a detailed pore network model was developed to simulate the processes of
methane hydrate dissociation and formation. However, the numerical simulations
revealed that assuming an isothermal process for hydrate formation and dissociation
is not physically realistic. Consequently, the results obtained …
The Influence Of Life Skills, Teammate And Coach Behavior, And The Sport Environment On The Mental Well-Being Of Intercollegiate Athletes, Lauren A. Shute
The Influence Of Life Skills, Teammate And Coach Behavior, And The Sport Environment On The Mental Well-Being Of Intercollegiate Athletes, Lauren A. Shute
LSU Doctoral Dissertations
Abstract
Intercollegiate athletics generate significant interest in the United States, where concerns about the health and well-being of student-athletes have gained increased attention in recent years. Student-athletes face the same developmental challenges as their non-athlete college peers, but they also encounter biological, psychological, sociocultural, and spiritual challenges often introduced or exacerbated by their participation in sport. To assist this subgroup of the college student population in managing their various athletic, academic, and personal responsibilities, the National Collegiate Athletic Association (NCAA) has prioritized and implemented life skills programming. Yet, while much has been documented regarding life skills development at the youth …
Identifying Saharan Air Layer Events And Their Relationship To Instability And Rainfall Patterns In The Tropical North Atlantic Ocean, Charles H. Dolce
Identifying Saharan Air Layer Events And Their Relationship To Instability And Rainfall Patterns In The Tropical North Atlantic Ocean, Charles H. Dolce
LSU Master's Theses
Every year, strong North African winds across the Sahara loft dust particles and advect them westward within the Saharan Air Layer (SAL). These plumes of dust often reach the Caribbean Sea and can heavily affect regional weather patterns by suppressing convection. When concentrations are high, decreased rainfall can yield negative societal and ecological impacts, potentially leading to drought. The Puerto Rican early rainfall season (ERS), spanning from 1 April through 31 July, overlaps with Saharan dust migration periods, and systematically detecting instances of SAL activity near the island is important for understanding longer-term drought-forcing trends in the region.
Corridors of …
Revolting Drag: Filth, Horror, And The Queer Art Of Monstrosity, Claire-Scott A. Lynch
Revolting Drag: Filth, Horror, And The Queer Art Of Monstrosity, Claire-Scott A. Lynch
LSU Master's Theses
This thesis examines how The Boulet Brothers’ Dragula, a horror-themed reality drag competition series, uses monstrosity as a tool of queer resistance. In contrast to mainstream drag representations, which often promote assimilationist ideals, Dragula embraces filth, grotesqueries, and failure as strategies of disrupting normative structures. Grounded in queer theory and queer of color critique, this thesis uses thematic analysis to explore how Dragula mobilizes monstrosity to resist normative portrayals of queerness. Through close analysis of the show’s season finales, the study identifies three major themes: grotesque aesthetics, beyond the binary, and identity as resistance. These findings reveal how Dragula positions …
Chain Theorems For Different Classes Of 3-Connected Graphs, Avin Sunuwar
Chain Theorems For Different Classes Of 3-Connected Graphs, Avin Sunuwar
LSU Doctoral Dissertations
This dissertation explores the structural properties of graphs by extending the classical result of Tutte's Wheel Theorem. In particular, we develop an improved version of Tutte's Wheel Theorem along with new chain theorems for subclasses of 3-connected graphs. These chain theorems provide a systematic approach to characterizing graphs that exclude certain minors, leading to significantly shorter proofs of established results.
In Chapter 5, we present a generalization of the block-tree theorem for connected graphs, which removes the restriction on cut vertices and allows greater flexibility in separator sizes. By integrating the results from Chapters 3, 4, and 5, we …
Redefining Actor Training: Prioritizing Mental Health And Ethical Pedagogy In Higher Education Actor Training Programs, Dori R. Leeman
Redefining Actor Training: Prioritizing Mental Health And Ethical Pedagogy In Higher Education Actor Training Programs, Dori R. Leeman
LSU Doctoral Dissertations
In recent years, higher education personnel across the country have referred to the pervasiveness of mental health challenges on college campuses as an epidemic. Students majoring in theatre and performance are no exception. This dissertation examines the unique factors of actor training programs and their impact on student actors’ mental health and well-being. Many traditional actor training programs have long upheld the notion that great artistry requires personal sacrifices, which include a lack of work-life balance and, at times, practices that blur the boundaries between life and art. I argue that actor training programs have failed to evolve alongside current …
Optimizing Fisher Information In Quantum Technology, Bran Purvis
Optimizing Fisher Information In Quantum Technology, Bran Purvis
LSU Doctoral Dissertations
Fisher information is a statistical metric whose inverse represents a lower bound on the variance of an unbiased estimator. Naturally, in order to make the best estimates of a given unknown parameter, one would desire to find ways to minimize the value of this lower bound. Thus, the Fisher information can also be used to compare the quality of different estimators for a given parameter: whichever estimator has a lower value for its Fisher information must also provide better estimates. The same holds true in the framework of quantum information theory, where an analog to the Fisher information, dubbed quantum …
Gaussian Quantum Markov Semigroups In The Fock-Anti-Fock Representation Of Weyl Algebra, A Dhahri, Franco Fagnola, D Poletti, Hyun Jae Yoo
Gaussian Quantum Markov Semigroups In The Fock-Anti-Fock Representation Of Weyl Algebra, A Dhahri, Franco Fagnola, D Poletti, Hyun Jae Yoo
Journal of Stochastic Analysis
No abstract provided.
A Skill Assessment Framework For The Fisheries And Marine Ecosystem Model Intercomparison Project, Nina Rynne, Camilla Novaglio, Julia Blanchard, Daniele Bianchi, Villy Christensen, Marta Coll, Jerome Guiet, Jeroen Steenbeek, Andrea Bryndum-Buchholz, Tyler D. Eddy, Cheryl Harrison, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Derek P. Tittensor, Ryan F. Heneghan
A Skill Assessment Framework For The Fisheries And Marine Ecosystem Model Intercomparison Project, Nina Rynne, Camilla Novaglio, Julia Blanchard, Daniele Bianchi, Villy Christensen, Marta Coll, Jerome Guiet, Jeroen Steenbeek, Andrea Bryndum-Buchholz, Tyler D. Eddy, Cheryl Harrison, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Derek P. Tittensor, Ryan F. Heneghan
Faculty Publications
Understanding climate change impacts on global marine ecosystems and fisheries requires complex marine ecosystem models, forced by global climate projections, that can robustly detect and project changes. The Fisheries and Marine Ecosystems Model Intercomparison Project (FishMIP) uses an ensemble modeling approach to fill this crucial gap. Yet FishMIP does not have a standardised skill assessment framework to quantify the ability of member models to reproduce past observations and to guide model improvement. In this study, we apply a comprehensive model skill assessment framework to a subset of global FishMIP models that produce historical fisheries catches. We consider a suite of …
Astaxanthin Protects Against Environmentally Persistent Free Radical-Induced Oxidative Stress In Well-Differentiated Respiratory Epithelium, Ayaho Yamamoto, Peter D. Sly, Lavrent Khachatryan, Nelufa Begum, Abrey J. Yeo, Paul D. Robinson, Stephania A. Cormier, Emmanuelle Fantino
Astaxanthin Protects Against Environmentally Persistent Free Radical-Induced Oxidative Stress In Well-Differentiated Respiratory Epithelium, Ayaho Yamamoto, Peter D. Sly, Lavrent Khachatryan, Nelufa Begum, Abrey J. Yeo, Paul D. Robinson, Stephania A. Cormier, Emmanuelle Fantino
Division of Basic Science Faculty Publications
Environmentally persistent free radicals (EPFRs) are combustion products present in substantial numbers on atmospheric particulate matter with half-lives of days to years. The mechanisms linking EPFR exposure and respiratory diseases are unclear, but likely involve oxidative stress. We investigated the mechanisms by which EPFR exposure impact on well-differentiated primary human nasal epithelial cells from subjects sensitive or resistant to oxidant stressors, cultured at an air-liquid interface. We found that EPFR exposure induced mitochondrial reactive oxygen species (mtROS) production; increased mitochondrial DNA copy number; down-regulated mucus production gene, Mucin-5AC (MUC5AC); up-regulated detoxifying gene, cytochrome P450 1A1 (CYP1A1), nuclear factor erythroid 2-related …