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The Imaging X-Ray Polarimetry Explorer 2.5 Years Later, Paolo Soffitta, Luca Baldini, Wayne Baumgartner, Ronaldo Bellazzini, Stephen D. Bongiorno, Niccolò Bucciantini, Enrico Costa, Michal Dovčiak, Steven Ehlert, Philip E. Kaaret, Jeffery J. Kolodziejczak, Luca Latronico, Frédréic Marin, Alan P. Marscher, Herman L. Marshall, Giorgio Matt, Fabio Muleri, Stephen L. O'Dell, Juri Poutanen, Brian Ramsey, Roger W. Romani, Patrick Slane, Allyn F. Tennant, Roberto Turolla, Martin C. Weisskopf, Iván Agudo, Lucio Angelo Antonelli, Matteo Bachetti, Stefano Bianchi, Raffaella Bonino, Alessandro Brez, Fiamma Capitanio, Simone Castellano Jan 2024

The Imaging X-Ray Polarimetry Explorer 2.5 Years Later, Paolo Soffitta, Luca Baldini, Wayne Baumgartner, Ronaldo Bellazzini, Stephen D. Bongiorno, Niccolò Bucciantini, Enrico Costa, Michal Dovčiak, Steven Ehlert, Philip E. Kaaret, Jeffery J. Kolodziejczak, Luca Latronico, Frédréic Marin, Alan P. Marscher, Herman L. Marshall, Giorgio Matt, Fabio Muleri, Stephen L. O'Dell, Juri Poutanen, Brian Ramsey, Roger W. Romani, Patrick Slane, Allyn F. Tennant, Roberto Turolla, Martin C. Weisskopf, Iván Agudo, Lucio Angelo Antonelli, Matteo Bachetti, Stefano Bianchi, Raffaella Bonino, Alessandro Brez, Fiamma Capitanio, Simone Castellano

Faculty Publications

We have, at last, an observatory dedicated to X-ray polarimetry that has been operational since December 9th, 2021. The Imaging X-ray Polarimetry Explorer (IXPE) is a NASA SMEX mission, in partnership with ASI, based on three X-ray telescopes, each equipped with a polarization-sensitive detector in the focus. An extending boom was deployed in orbit, positioning the detectors at the optimal distance from the optics, which have a 4-meter focal length. The spacecraft is three-axis stabilized, providing power, attitude determination and control, transmission, and commanding capabilities. After two and a half years of observation, IXPE has detected positive polarization …


X-Ray Polarization Of The Eastern Lobe Of Ss 433, Philip Kaaret, Riccardo Ferrazzoli, Stefano Silvestri, Michela Negro, Alberto Manfreda, Kinwah Wu, Enrico Costa, Paolo Soffitta, Samar Safi-Harb, Juri Poutanen, Alexandra Veledina, Alessandro Di Marco, Patrick Slane, Stefano Bianchi, Adam Ingram, Roger W. Romani, Nicolò Cibrario, Brydyn Mac Intyre, Romana Mikus̆Incová, Ajay Ratheesh, James F. Steiner, Jiri Svoboda, Stefano Tugliani, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Niccolò Bucciantini Jan 2024

X-Ray Polarization Of The Eastern Lobe Of Ss 433, Philip Kaaret, Riccardo Ferrazzoli, Stefano Silvestri, Michela Negro, Alberto Manfreda, Kinwah Wu, Enrico Costa, Paolo Soffitta, Samar Safi-Harb, Juri Poutanen, Alexandra Veledina, Alessandro Di Marco, Patrick Slane, Stefano Bianchi, Adam Ingram, Roger W. Romani, Nicolò Cibrario, Brydyn Mac Intyre, Romana Mikus̆Incová, Ajay Ratheesh, James F. Steiner, Jiri Svoboda, Stefano Tugliani, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Niccolò Bucciantini

Faculty Publications

How astrophysical systems translate the kinetic energy of bulk motion into the acceleration of particles to very high energies is a pressing question. SS 433 is a microquasar that emits TeV γ-rays indicating the presence of high-energy particles. A region of hard X-ray emission in the eastern lobe of SS 433 was recently identified as an acceleration site. We observed this region with the Imaging X-ray Polarimetry Explorer and measured a polarization degree in the range 38%-77%. The high polarization degree indicates the magnetic field has a well-ordered component if the X-rays are due to synchrotron emission. The polarization angle …


The African Light Source: History, Context And Future, Simon H. Connell, Kathleen Dollman, Gihan Kamel, Sameen A. Khan, Edward Mitchell, Sekazi K. Mtingwa, Marcus C. Newton, Prosper Ngabonziza, Emmanuel Nji, Lawrence Norris, Michele Zema Jan 2024

The African Light Source: History, Context And Future, Simon H. Connell, Kathleen Dollman, Gihan Kamel, Sameen A. Khan, Edward Mitchell, Sekazi K. Mtingwa, Marcus C. Newton, Prosper Ngabonziza, Emmanuel Nji, Lawrence Norris, Michele Zema

Faculty Publications

The African Light Source (AfLS) project is now almost eight years old. This article assesses the history, current context and future of the project. There is by now considerable momentum in building the user community, including deep training, facilitating access to current facilities, growing the scientific output, scientific networks and growing the local laboratory-scale research infrastructure. The Conceptual Design Report for the AfLS is in its final editing stages. This document specifies the socio-economic and scientific rationales and the technical aspects amongst others. The AfLS is supported by many national and Pan-African scientific professional bodies and voluntary associates across many …


Editorial: Disorder And Superconductivity: A 21st-Century Update, Ruslan Prozorov, James Avery Sauls, Peter Hirschfeld, Nigel E. Hussey, Maria Iavarone Jan 2024

Editorial: Disorder And Superconductivity: A 21st-Century Update, Ruslan Prozorov, James Avery Sauls, Peter Hirschfeld, Nigel E. Hussey, Maria Iavarone

Faculty Publications

No abstract provided.


Editorial: Rising Stars In Systems Neuroscience: 2022, Mazyar Fallah, Juhee Haam, Ada Ledonne Jan 2024

Editorial: Rising Stars In Systems Neuroscience: 2022, Mazyar Fallah, Juhee Haam, Ada Ledonne

Faculty Publications

No abstract provided.


Oxphos Capacity Is Diminished And The Phosphorylation System Inhibited During Diapause In An Extremophile, Embryos Of Artemia Franciscana, Yuvraj N. Patil, Erich Gnaiger, Alexander P. Landry, Zachary J. Leno, Steven C. Hand Jan 2024

Oxphos Capacity Is Diminished And The Phosphorylation System Inhibited During Diapause In An Extremophile, Embryos Of Artemia Franciscana, Yuvraj N. Patil, Erich Gnaiger, Alexander P. Landry, Zachary J. Leno, Steven C. Hand

Faculty Publications

Diapause exhibited by embryos of Artemia franciscana is accompanied by severe arrest of respiration. A large fraction of this depression is attributable to downregulation of trehalose catabolism that ultimately restricts fuel to mitochondria. This study now extends knowledge on the mechanism by revealing metabolic depression is heightened by inhibitions within mitochondria. Compared with that in embryo lysates during post-diapause, oxidative phosphorylation (OXPHOS) capacity P is depressed during diapause when either NADH-linked substrates (pyruvate and malate) for electron transfer (electron transfer capacity, E) through respiratory Complex I or the Complex II substrate succinate are used. When pyruvate, malate and succinate were …


Phosphatidic Acid Produced By Phospholipase Dα1 And Dδ Is Incorporated Into The Internal Membranes But Not Involved In The Gene Expression Of Rd29a In The Abscisic Acid Signaling Network In Arabidopsis Thaliana, Ruth Ndathe, Naohiro Kato Jan 2024

Phosphatidic Acid Produced By Phospholipase Dα1 And Dδ Is Incorporated Into The Internal Membranes But Not Involved In The Gene Expression Of Rd29a In The Abscisic Acid Signaling Network In Arabidopsis Thaliana, Ruth Ndathe, Naohiro Kato

Faculty Publications

Core protein components of the abscisic acid (ABA) signaling network, pyrabactin resistance (PYR), protein phosphatases 2C (PP2C), and SNF1-related protein kinase 2 (SnRK2) are involved in the regulation of stomatal closure and gene expression downstream responses in Arabidopsis thaliana. Phosphatidic acid (PA) produced by the phospholipases Dα1 and Dδ (PLDs) in the plasma membrane has been identified as a necessary molecule in ABA-inducible stomatal closure. On the other hand, the involvement of PA in ABA-inducible gene expression has been suggested but remains a question. In this study, the involvement of PA in the ABA-inducible gene expression was examined in the …


Transcriptomic Responses To Hypoxia In Two Populations Of Eastern Oyster With Differing Tolerance, Emma L. Crable, Heather Rodriguez, Rujuta V. Vaidya, Nicholas Coxe, Jerome F. La Peyre, Morgan W. Kelly Jan 2024

Transcriptomic Responses To Hypoxia In Two Populations Of Eastern Oyster With Differing Tolerance, Emma L. Crable, Heather Rodriguez, Rujuta V. Vaidya, Nicholas Coxe, Jerome F. La Peyre, Morgan W. Kelly

Faculty Publications

The eastern oyster, Crassostrea virginica, is a keystone species native to the Gulf of Mexico and Atlantic coasts of the United States and Canada. It provides habitat for other marine organisms and makes up the majority of oyster production in the United States. Despite its tolerance to hypoxic conditions, C. virginica is threatened by anthropogenic climate change, which is increasing both average temperature and the frequency and severity of hypoxic events. In this study, we explore the differences in hypoxia-transcriptional response between two populations of eastern oysters with known differences in hypoxia tolerance at three time points over the course …


Deep Purple – An Open-Pollinated Variety To Induce Haploids In Tropical Maize, Roberto Fritsche-Neto, Felipe Sabadin, Evellyn Giselly De Oliveira Couto, Pedro Henrique De Souza, Filipe Couto Alves, Giovanni Galli, Ronaldo Borsato Junior, Julio Cesar Dovale, Karina Lima Reis Borges, Deoclécio Domingos Garbuglio Jan 2024

Deep Purple – An Open-Pollinated Variety To Induce Haploids In Tropical Maize, Roberto Fritsche-Neto, Felipe Sabadin, Evellyn Giselly De Oliveira Couto, Pedro Henrique De Souza, Filipe Couto Alves, Giovanni Galli, Ronaldo Borsato Junior, Julio Cesar Dovale, Karina Lima Reis Borges, Deoclécio Domingos Garbuglio

Faculty Publications

Deep purple is an open-pollinated variety, well adapted to tropical conditions, developed to induce maternal haploids in maize. The founders were W23, Stock6, and an experimental tropical maize population. The inducer population inherits the dominant the R1-nj marker, and the expected real haploid induction rate is 3%.


Feature Engineering Of Environmental Covariates Improves Plant Genomic-Enabled Prediction, Osval A. Montesinos-López, Leonardo Crespo-Herrera, Carolina Saint Pierre, Bernabe Cano-Paez, Gloria Isabel Huerta-Prado, Brandon Alejandro Mosqueda-González, Sofia Ramos-Pulido, Guillermo Gerard, Khalid Alnowibet, Roberto Fritsche-Neto, Abelardo Montesinos-López, José Crossa Jan 2024

Feature Engineering Of Environmental Covariates Improves Plant Genomic-Enabled Prediction, Osval A. Montesinos-López, Leonardo Crespo-Herrera, Carolina Saint Pierre, Bernabe Cano-Paez, Gloria Isabel Huerta-Prado, Brandon Alejandro Mosqueda-González, Sofia Ramos-Pulido, Guillermo Gerard, Khalid Alnowibet, Roberto Fritsche-Neto, Abelardo Montesinos-López, José Crossa

Faculty Publications

Introduction: Because Genomic selection (GS) is a predictive methodology, it needs to guarantee high-prediction accuracies for practical implementations. However, since many factors affect the prediction performance of this methodology, its practical implementation still needs to be improved in many breeding programs. For this reason, many strategies have been explored to improve the prediction performance of this methodology. Methods: When environmental covariates are incorporated as inputs in the genomic prediction models, this information only sometimes helps increase prediction performance. For this reason, this investigation explores the use of feature engineering on the environmental covariates to enhance the prediction performance of genomic …


Ba5sb8: The Highest Homologue Of The Family Of Binary Semiconducting Barium Antimonides Bansb2n−2 (N ≥ 2), S. M.Gayomi K. Samarakoon, Alexander Ovchinnikov, Sviatoslav Baranets, Svilen Bobev Jan 2024

Ba5sb8: The Highest Homologue Of The Family Of Binary Semiconducting Barium Antimonides Bansb2n−2 (N ≥ 2), S. M.Gayomi K. Samarakoon, Alexander Ovchinnikov, Sviatoslav Baranets, Svilen Bobev

Faculty Publications

A novel binary compound within the Ba–Sb phase diagram, Ba5Sb8, was synthesized by combining elements with an excess of Sb in an alumina crucible. Structural elucidation was performed using single-crystal X-ray diffraction. This compound crystallizes in the orthorhombic space group Fdd2 with unit cell parameters of a = 15.6568(13) Å, b = 35.240(3) Å, c = 6.8189(6) Å, adopting its own structure type. The most distinctive features of the structure are the eight-membered [Sb8]10− polyanionic fragments which have no known precedents among antimonides. They are separated by five Ba2+ cations, which afford the charge balance and enable adherence …


Enriched Molecular-Level View Of Saline Wetland Soil Carbon By Sensitivity-Enhanced Solid-State Nmr, Wancheng Zhao, Elizabeth C. Thomas, Debkumar Debnath, Faith J. Scott, Frederic Mentink-Vigier, John R. White, Robert L. Cook, Tuo Wang Jan 2024

Enriched Molecular-Level View Of Saline Wetland Soil Carbon By Sensitivity-Enhanced Solid-State Nmr, Wancheng Zhao, Elizabeth C. Thomas, Debkumar Debnath, Faith J. Scott, Frederic Mentink-Vigier, John R. White, Robert L. Cook, Tuo Wang

Faculty Publications

Soil organic matter (SOM) plays a major role in mitigating greenhouse gas emission and regulating earth’s climate, carbon cycle, and biodiversity. Wetland soils account for one-third of all SOM; however, globally, coastal wetland soils are eroding faster due to increasing sea-level rise. Our understanding of carbon sequestration dynamics in wetlands lags behind that of upland soils. Here, we employ solid-state nuclear magnetic resonance (ssNMR) to investigate the molecular-level structure of biopolymers in wetland soils spanning 11 centuries. High-resolution multidimensional spectra, enabled by dynamic nuclear polarization (DNP), demonstrate enduring preservation of molecular structures within herbaceous plant cores, notably condensing aromatic motifs …


Transitioning From Regular Electrolytes To Solvate Ionic Liquids To High-Concentration Electrolytes: Changes In Transport Properties And Ionic Speciation, Ernest O. Nachaki, Daniel G. Kuroda Jan 2024

Transitioning From Regular Electrolytes To Solvate Ionic Liquids To High-Concentration Electrolytes: Changes In Transport Properties And Ionic Speciation, Ernest O. Nachaki, Daniel G. Kuroda

Faculty Publications

Glyme-based lithium-ion electrolytes have received considerable attention from the scientific community due to their improved safety, as well as electrochemical and thermal stability over carbonate-based electrolytes. However, these electrolytes suffer from major drawbacks such as high viscosities. To overcome the challenges that hinder their full potential, the molecular description of glyme-based lithium electrolytes in the high-concentration regime, particularly in the solvate ionic liquid (SIL) and high-concentration electrolyte (HCE) regimes, is needed. In this study, model glyme-based electrolytes based on a lithium thiocyanate and either tetraglyme (G4) or a mixture of monoglyme (G1) and diglyme (G2) were investigated as a function …


Pseudomonas Aeruginosa Gene Pa4880 Encodes A Dps-Like Protein With A Dps Fold, Bacterioferritin-Type Ferroxidase Centers, And Endonuclease Activity, Nimesha Rajapaksha, Huili Yao, Aisha Cook, Steve Seibold, Lijun Liu, Kevin P. Battaile, Leo Fontenot, Fabrizio Donnarumma, Scott Lovell, Mario Rivera Jan 2024

Pseudomonas Aeruginosa Gene Pa4880 Encodes A Dps-Like Protein With A Dps Fold, Bacterioferritin-Type Ferroxidase Centers, And Endonuclease Activity, Nimesha Rajapaksha, Huili Yao, Aisha Cook, Steve Seibold, Lijun Liu, Kevin P. Battaile, Leo Fontenot, Fabrizio Donnarumma, Scott Lovell, Mario Rivera

Faculty Publications

We report the biochemical, structural, and functional characterization of the protein coded by gene PA4880 in the P. aeruginosa PAO1 genome. The PA4880 gene had been annotated as coding a probable bacterioferritin. Our structural work shows that the product of gene PA4880 is a protein that adopts the Dps subunit fold, which oligomerizes into a 12-mer quaternary structure. Unlike Dps, however, the ferroxidase di-iron centers and iron coordinating ligands are buried within each subunit, in a manner identical to that observed in the ferroxidase center of P. aeruginosa bacterioferritin. Since these structural characteristics correspond to Dps-like proteins, we term the …


Recent Advances In Chemistry And Antioxidant/Anticancer Biology Of Monoterpene And Meroterpenoid Natural Product, Benedict J. Barras, Taotao Ling, Fatima Rivas Jan 2024

Recent Advances In Chemistry And Antioxidant/Anticancer Biology Of Monoterpene And Meroterpenoid Natural Product, Benedict J. Barras, Taotao Ling, Fatima Rivas

Faculty Publications

Monoterpenes and meroterpenes are two large classes of isoprene-based molecules produced by terrestrial plants and unicellular organisms as diverse secondary metabolites. The global rising incidence of cancer has led to a renewed interest in natural products. These monoterpenes and meroterpenes represent a novel source of molecular scaffolds that can serve as medicinal chemistry platforms for the development of potential preclinical leads. Furthermore, some of these natural products are either abundant, or their synthetic strategies are scalable as it will be indicated here, facilitating their derivatization to expand their scope in drug discovery. This review is a collection of representative updates …


On The Relevance Of Glycosyl Oxonium Ions To 1,2-Cis-Selective O-Glycosylation In Ether Solvents, Varad Agarkar, Ava E. Hart, Justin R. Ragains Jan 2024

On The Relevance Of Glycosyl Oxonium Ions To 1,2-Cis-Selective O-Glycosylation In Ether Solvents, Varad Agarkar, Ava E. Hart, Justin R. Ragains

Faculty Publications

Since no later than the 1970s, organic chemists have speculated on the role of glycosyl oxonium ions in chemical O-glycosylation. Such species result from the attack of ethers on glycosyl oxocarbenium ions and are invoked to explain 1,2-cis-selectivity in ether solvents. However, a systematic study to probe this phenomenon appears to be lacking in the chemical literature. Herein, we study the effects of solvent, counteranion, protecting group electron-withdrawing effects, and acceptor on O-glycosylation stereoselectivity with D-glucosyl trichloroacetimidate donors. While many of these transformations proceed with 1,2-cis-selectivity, our results suggest that glycosyl oxonium ions play minimal, if any, role in O-glycosylation.


The Role Of Holistic Mentoring Ecosystems In Mitigating Covid-19 Pandemic Impacts On The Persistence Of Low-Income Stem Students, Raeshan D. Davis, Zakiya S. Wilson-Kennedy Jan 2024

The Role Of Holistic Mentoring Ecosystems In Mitigating Covid-19 Pandemic Impacts On The Persistence Of Low-Income Stem Students, Raeshan D. Davis, Zakiya S. Wilson-Kennedy

Faculty Publications

Holistic mentoring ecosystems are a comprehensive approach to addressing the diverse needs of students through interconnected support networks. While mentoring has been well-documented in existing literature, more research is needed to determine the effectiveness of mentoring ecosystems in mitigating the impact of critical junctures for vulnerable, high-attrition student populations. Guided by Tinto’s model of retention, this qualitative case study investigated the role of holistic mentoring ecosystems in mitigating the impacts of the two combined critical junctures—the COVID-19 pandemic and the first year of college—on low-income STEM undergraduates. Our findings suggest that holistic mentoring ecosystems were essential in helping students adjust …


Modelling And Simulation Of The Cholesteric Landau-De Gennes Model, Andrew L. Hicks, Shawn W. Walker Jan 2024

Modelling And Simulation Of The Cholesteric Landau-De Gennes Model, Andrew L. Hicks, Shawn W. Walker

Faculty Publications

This paper discusses modelling and numerical issues in the simulation of the Landau-de Gennes (LdG) model of nematic liquid crystals (LCs) with cholesteric effects. We propose a fully implicit, (weighted) L2 gradient flow for computing energy minimizers of the LdG model, and note a time-step restriction for the flow to be energy decreasing. Furthermore, we give a mesh size restriction, for finite-element discretizations, that is critical to avoid spurious numerical artifacts in discrete minimizers, particularly when simulating cholesteric LCs that exhibit 'twist.' Furthermore, we perform a computational exploration of the model and present several numerical simulations in three dimensions, on …


Lsu General Catalog 2024-2025, Louisiana State University And Agricultural And Mechanical College Jan 2024

Lsu General Catalog 2024-2025, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.


A Cogroupoid Associated To Preregular Forms, Hongdi Huang, Van C. Nguyen, Charlotte Ure, Kent B. Vashaw, Padmini Veerapen, Xingting Wang Jan 2024

A Cogroupoid Associated To Preregular Forms, Hongdi Huang, Van C. Nguyen, Charlotte Ure, Kent B. Vashaw, Padmini Veerapen, Xingting Wang

Faculty Publications

We construct a family of cogroupoids associated to preregular forms and recover the Morita–Takeuchi equivalence for Artin–Schelter regular algebras of dimension two, observed by Raedschelders and Van den Bergh. Moreover, we study the 2-cocycle twists of pivotal analogues of these cogroupoids, by developing a categorical description of preregularity in any tensor category that has a pivotal structure.


On The Maximum Spread Of Planar And Outerplanar Graphs, Zelong Li, William Linz, Linyuan Lu, Zhiyu Wang Jan 2024

On The Maximum Spread Of Planar And Outerplanar Graphs, Zelong Li, William Linz, Linyuan Lu, Zhiyu Wang

Faculty Publications

The spread of a graph G is the difference between the largest and smallest eigenvalue of the adjacency matrix of G. Gotshall, O’Brien and Tait conjectured that for sufficiently large n, the n-vertex outerplanar graph with maximum spread is the graph obtained by joining a vertex to a path on n − 1 vertices. In this paper, we disprove this conjecture by showing that the extremal graph is the graph obtained by joining a vertex to a path on ⌈(2n − 1)/3⌉ vertices and ⌊(n − 2)/3⌋ isolated vertices. For planar graphs, we show that the extremal n-vertex planar graph …


Molecular And Cellular Programs Underlying The Development Of Bovine Pre-Implantation Embryos, Zongliang Jiang Jan 2024

Molecular And Cellular Programs Underlying The Development Of Bovine Pre-Implantation Embryos, Zongliang Jiang

Faculty Publications

Early embryonic mortality is a major cause of infertility in cattle, yet the underlying molecular causes remain a mystery. Over the past half century, assisted reproductive technologies such as in vitro fertilisation and somatic cell nuclear transfer have been used to improve cattle reproductive efficiency; however, reduced embryo developmental potential is seen compared to their in vivo counterparts. Recent years have seen exciting progress across bovine embryo research, including genomic profiling of embryogenesis, new methods for improving embryo competence, and experimenting on building bovine embryos from stem cell cultures. These advances are beginning to define bovine embryo molecular and cellular …


Th2 And Th17-Associated Immunopathology Following Sars-Cov-2 Breakthrough Infection In Spike-Vaccinated Ace2-Humanized Mice, Tianyi Zhang, Nicholas Magazine, Michael C. Mcgee, Mariano Carossino, Gianluca Veggiani, Konstantin G. Kousoulas, Avery August, Weishan Huang Jan 2024

Th2 And Th17-Associated Immunopathology Following Sars-Cov-2 Breakthrough Infection In Spike-Vaccinated Ace2-Humanized Mice, Tianyi Zhang, Nicholas Magazine, Michael C. Mcgee, Mariano Carossino, Gianluca Veggiani, Konstantin G. Kousoulas, Avery August, Weishan Huang

Faculty Publications

Vaccines have demonstrated remarkable effectiveness in protecting against COVID-19; however, concerns regarding vaccine-associated enhanced respiratory diseases (VAERD) following breakthrough infections have emerged. Spike protein subunit vaccines for SARS-CoV-2 induce VAERD in hamsters, where aluminum adjuvants promote a Th2-biased immune response, leading to increased type 2 pulmonary inflammation in animals with breakthrough infections. To gain a deeper understanding of the potential risks and the underlying mechanisms of VAERD, we immunized ACE2-humanized mice with SARS-CoV-2 Spike protein adjuvanted with aluminum and CpG-ODN. Subsequently, we exposed them to increasing doses of SARS-CoV-2 to establish a breakthrough infection. The vaccine elicited robust neutralizing antibody …


Fitness Promotion In College: The Relationships Among Students’ Perceived Physical Literacy, Knowledge, And Physical Fitness, Bin Long, Yang Liu, Senlin Chen, Yiwu Yang, Suna Tang, Jimei Yang, Yuhuai Wang Jan 2024

Fitness Promotion In College: The Relationships Among Students’ Perceived Physical Literacy, Knowledge, And Physical Fitness, Bin Long, Yang Liu, Senlin Chen, Yiwu Yang, Suna Tang, Jimei Yang, Yuhuai Wang

Faculty Publications

Purpose: The purpose of this study was to examine the relationships among perceived physical literacy (PPL), knowledge of physical activity and fitness (PAF knowledge), and physical fitness. Methods: Undergraduates (N = 968, female = 414; Mage = 18.64) from a public university in central China completed a simplified Chinese version of the PPL instrument, an online test for PAF knowledge, and seven health-related physical fitness tests. The PPL includes three dimensions: (a) confidence and physical competence, (b) motivation, and (c) interaction with the environment. The fitness tests measured lung capacity, body mass index (BMI), and performances in 800 (female)/1000 (male) …


Motor Problems In Autism: Co-Occurrence Or Feature?, Haylie L. Miller, Melissa K. Licari, Anjana Bhat, Lisa S. Aziz-Zadeh, Tine Van Damme, Nicholas E. Fears, Sharon A. Cermak, Priscila M. Tamplain Jan 2024

Motor Problems In Autism: Co-Occurrence Or Feature?, Haylie L. Miller, Melissa K. Licari, Anjana Bhat, Lisa S. Aziz-Zadeh, Tine Van Damme, Nicholas E. Fears, Sharon A. Cermak, Priscila M. Tamplain

Faculty Publications

Motor features of autism have long been acknowledged by clinicians, researchers, and community stakeholders. Current DSM-5 and ICD-11 guidelines allow clinicians to assign a co-occurring diagnosis of developmental [motor] coordination disorder (DCD) for autistic individuals with significant motor problems. DCD is characterized by poor motor proficiency with an onset of symptoms in early development. Studies have shown considerable overlap in the behavioral motor features observed in autism and DCD. However, others indicate that motor problems in autism and DCD may stem from different underlying sensorimotor mechanisms. Regardless of whether autism has a unique motor phenotype or an overlap with DCD, …


Editorial: Digital Technology In The Management And Prevention Of Diabetes, Yun Shen, Xiantong Zou, Gang Hu Jan 2024

Editorial: Digital Technology In The Management And Prevention Of Diabetes, Yun Shen, Xiantong Zou, Gang Hu

Population and Public Health Science Faculty Publications

No abstract provided.


Dietary Intakes Of Branch Chained Amino Acids And Obesity Risk Among Chinese Gestational Diabetes Women, Xiaoyun Yang, Weiqin Li, Wei Li, Huikun Liu, Leishen Wang, Junhong Leng, Yuxin Fan, Xilin Yang, Ming Liu, Gang Hu Jan 2024

Dietary Intakes Of Branch Chained Amino Acids And Obesity Risk Among Chinese Gestational Diabetes Women, Xiaoyun Yang, Weiqin Li, Wei Li, Huikun Liu, Leishen Wang, Junhong Leng, Yuxin Fan, Xilin Yang, Ming Liu, Gang Hu

Population and Public Health Science Faculty Publications

Introduction: Epidemiological studies have assessed the correlation between daily dietary branch chain amino acid (BCAA) intakes and the risk of obesity, however, the findings from these studies were inconsistent and investigations among GDM women were few. Objective: The present study was to investigate the associations of daily BCAA intakes with the risks of overweight and abdominal obesity among women with prior gestational diabetes mellitus (GDM) postpartum. Method: We performed a cross-sectional study of 1,263 women with prior GDM at 1–5 years post-delivery. Logistic regression models were used to estimate the associations of daily dietary intakes of BCAAs with the risks …


An Examination Of Homo Naledi Early Juveniles Recovered From The Rising Star Cave System, South Africa, Juliet K. Brophy, Debra R. Bolter, Marina Elliott, John Hawks, Lee R. Berger Jan 2024

An Examination Of Homo Naledi Early Juveniles Recovered From The Rising Star Cave System, South Africa, Juliet K. Brophy, Debra R. Bolter, Marina Elliott, John Hawks, Lee R. Berger

Faculty Publications

Background: Six Homo naledi early juveniles were recovered from U.W. 101 (Dinaledi Chamber), U.W. 102 (Lesedi Chamber), and U.W. 110 in the Rising Star cave system. Aim: This paper develops the information for the H. naledi early juvenile life stage, as defined by a combination of deciduous and permanent dentition, and the eruption of the first permanent molar. Subjects and methods: The growing number of young individuals recovered from the Rising Star cave system allows us to gain a better understanding of their variation, or lack thereof, and provides a basis to estimate broad ranges for age at death of …


Human–Environment Interactions At Ta’Ab Nuk Na, A Submerged Maya Salt Works Site In Belize, Cheryl M. Foster, Heather Mckillop, E. Cory Sills Jan 2024

Human–Environment Interactions At Ta’Ab Nuk Na, A Submerged Maya Salt Works Site In Belize, Cheryl M. Foster, Heather Mckillop, E. Cory Sills

Faculty Publications

Sea-level rise and settlement are investigated at Ta’ab Nuk Na, an ancient Maya salt works in Belize, by examining samples from wooden posts and marine sediment. The samples included Post 145 of Building B and the Nunavut beam, along with marine sediment columns cut from beside both wooden posts. The sediment columns were sampled at 2 cm intervals. Loss-on ignition confirmed the presence of organic material. Identifying the organic content involved removing nonorganic material from the sediment and sorting the organic material under magnification. This procedure established that most of the organic material was red mangrove (Rhizophora mangle). Red mangroves …


Flooded Mangrove Landscapes Hide Ancient Maya Coastal Sites In Belize, Heather I. Mckillop Jan 2024

Flooded Mangrove Landscapes Hide Ancient Maya Coastal Sites In Belize, Heather I. Mckillop

Faculty Publications

Evidence of ancient Maya exploitation of salt, other marine resources, settlement, and sea trade is hidden in flooded mangrove landscapes on the cays, mainland, and in shallow offshore locations on the south coast of Belize. This article includes a discussion of the coastal economy from the Middle Preclassic through the Postclassic periods (600 B.C.–A.D. 1500). Data from sites discovered and excavated since 1982 in the coastal area of the Port Honduras and Paynes Creek National Park support a model of coastal reliance on marine resources and tree crops. The need for a regular supply of coastal salt to inland cities …