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Articles 541 - 570 of 15695
Full-Text Articles in Entire DC Network
Too Sensitive Or Not Sensitive Enough? Sensitivity To Context And Justice-Involved Youths' Response To Violence Exposure, Colleen Sbeglia, Curtis Donovyn Smith, Paul J. Frick, Laurence Steinberg, Elizabeth Cauffman
Too Sensitive Or Not Sensitive Enough? Sensitivity To Context And Justice-Involved Youths' Response To Violence Exposure, Colleen Sbeglia, Curtis Donovyn Smith, Paul J. Frick, Laurence Steinberg, Elizabeth Cauffman
Faculty Publications
With high rates of violence exposure among justice-involved youth, it is critical to identify factors that might impact the likelihood of youth engaging in violence themselves. One such factor is sensitivity to context, which describes how sensitive youth are to experiences in their environment. Using an ethnically diverse sample of justice-involved male adolescents (47% Latino, 38% Black/African American, 15% White) aged 13-17 at the time of their first arrest, the results of this study indicate that exposure to violence was related to increased violent behavior six months later, and this effect was strongest among youth who were low in sensitivity …
Determining Diabetic Kidney Disease Severity Using Traditional Chinese Medicine Syndrome Classification, Amanda Yun Rui Lam, Huang Fang Zheng, Kok Keong Teo, Xiao Hui Xin, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Hong Chang Tan
Determining Diabetic Kidney Disease Severity Using Traditional Chinese Medicine Syndrome Classification, Amanda Yun Rui Lam, Huang Fang Zheng, Kok Keong Teo, Xiao Hui Xin, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Hong Chang Tan
Division of Basic Science Faculty Publications
No abstract provided.
Effect Of Impaired Awareness Of Hypoglycemia On Glucose Decline During And After Exercise In The T1dexi Study, Jorge L. Jo Kamimoto, Zoey Li, Robin L. Gal, Jessica R. Castle, Francis J. Doyle, Peter G. Jacobs, Corby K. Martin, Roy W. Beck, Peter Calhoun, Michael C. Riddell, Michael R. Rickels
Effect Of Impaired Awareness Of Hypoglycemia On Glucose Decline During And After Exercise In The T1dexi Study, Jorge L. Jo Kamimoto, Zoey Li, Robin L. Gal, Jessica R. Castle, Francis J. Doyle, Peter G. Jacobs, Corby K. Martin, Roy W. Beck, Peter Calhoun, Michael C. Riddell, Michael R. Rickels
Clinical Research Faculty Publications
Context: Adults with type 1 diabetes (T1D) face the necessity of balancing the benefits of exercise with the potential hazards of hypoglycemia. Objective: This work aimed to assess whether impaired awareness of hypoglycemia (IAH) affects exercise-associated hypoglycemia in adults with T1D. Methods: We compared continuous glucose monitoring (CGM)-measured glucose during exercise and for 24 hours following exercise from 95 adults with T1D and IAH (Clarke score ≥4 or ≥1 severe hypoglycemic event within the past year) to 95 “aware” adults (Clarke score ≤2 and no severe hypoglycemic event within the past year) matched on sex, age, insulin delivery modality, and …
Louisiana Graduate Network In Applied Evolution (Lagniappe): 2023-2024 End-Year Report, Kristina Little, Samuel B. Robison, Bret Blackmon, Andrew R. Burns
Louisiana Graduate Network In Applied Evolution (Lagniappe): 2023-2024 End-Year Report, Kristina Little, Samuel B. Robison, Bret Blackmon, Andrew R. Burns
Reports
The Louisiana Graduate Network in Applied Evolution (hereinafter; LAGNiAppE) was funded by a grant awarded through the National Science Foundation (NSF 22-506), as part of the Research and Mentoring for Postbaccalaureates in Biological Sciences (RaMP) grant program. The LAGNiAppE program provides training and mentorship to cohorts of recent college graduates from underrepresented groups interested in advancing their knowledge and research skills in evolutionary biology. Social Research and Evaluation Center (SREC) at Louisiana State University conducted the evaluation of LAGNiAppE, assessing program implementation and impact. The evaluation team at SREC employed a mixed methods design that included online surveys for scholars …
Covid-19 Implications On Worksite Wellness Programming, Renee A. Underwood, Angela R. Wood, Ralph J. Wood, Rylie B. Broussard, Stephanie T. Broyles
Covid-19 Implications On Worksite Wellness Programming, Renee A. Underwood, Angela R. Wood, Ralph J. Wood, Rylie B. Broussard, Stephanie T. Broyles
Population and Public Health Science Faculty Publications
Seven of the top ten leading causes of death in the United States are due to chronic diseases and treating these accounts for 86 percent of our nation's health care costs. The workplace offers an environment to implement chronic disease prevention strategies, such as worksite wellness programs, due to the large amount of time spent at the worksite daily by employees. As a result of COVID-19, many organizations began to change their workdays (i.e., working from home). This research sought to understand what, if any, implications the COVID-19 epidemic had on worksite wellness programming. Semistructured interviews were employed and recorded …
Evaluating The Validity Of The Portionsize Smartphone Application For Estimating Dietary Intake In Free-Living Conditions: A Pilot Study, Hanim E. Diktas, Chloe P. Lozano, Sanjoy Saha, Stephanie T. Broyles, Corby K. Martin, John W. Apolzan
Evaluating The Validity Of The Portionsize Smartphone Application For Estimating Dietary Intake In Free-Living Conditions: A Pilot Study, Hanim E. Diktas, Chloe P. Lozano, Sanjoy Saha, Stephanie T. Broyles, Corby K. Martin, John W. Apolzan
Clinical Research Faculty Publications
Objective: Evaluate the validity of the PortionSize application. Methods: In this pilot study, 14 adults used PortionSize to record their free-living food intake over 3 consecutive days. Digital photography was the criterion measure, and the main outcomes were estimated intake of food (grams), energy (kilocalories), and food groups. Equivalence tests with ±25% equivalence bounds and Bland-Altman analysis were performed. Results: Estimated gram intake from PortionSize was equivalent (P < 0.001) to digital photography estimates. PortionSize and digital photography estimated energy intake, however, were not equivalent (P = 0.08), with larger estimates from PortionSize. In addition, PortionSize and digital photography were equivalent for vegetable intake (P = 0.01), but PortionSize had larger estimates of fruits, grains, dairy, and protein intake (P >0.07; error range 11% to 23%). Conclusions and Implications: Compared with digital photography, PortionSize accurately estimated food intake and had reasonable error rates for other nutrients; however, it overestimated energy intake, indicating …
High-Resolution Elemental Abundance Measurements Of Cool Jwst Planet Hosts Using Autospecfit: An Application To The Sub-Neptune K2-18b’S Host M Dwarf, Neda Hejazi, Ian J.M. Crossfield, Diogo Souto, Jonathan Brande, Thomas Nordlander, Emilio Marfil, Katia Cunha, David R. Coria, Zachary G. Maas, Alex S. Polanski, Natalie R. Hinkel, Joseph E. Hand
High-Resolution Elemental Abundance Measurements Of Cool Jwst Planet Hosts Using Autospecfit: An Application To The Sub-Neptune K2-18b’S Host M Dwarf, Neda Hejazi, Ian J.M. Crossfield, Diogo Souto, Jonathan Brande, Thomas Nordlander, Emilio Marfil, Katia Cunha, David R. Coria, Zachary G. Maas, Alex S. Polanski, Natalie R. Hinkel, Joseph E. Hand
Faculty Publications
We present an in-depth, high-resolution spectroscopic analysis of the M dwarf K2-18, which hosts a sub-Neptune exoplanet in its habitable zone. We show our technique to accurately normalize the observed spectrum, which is crucial for a proper spectral fitting. We also introduce a new automatic, line-by-line, model-fitting code, AutoSpecFit, which performs an iterative χ 2 minimization process to measure individual elemental abundances of cool dwarfs. We apply this code to the star K2-18, and measure the abundance of 10 elements: C, O, Na, Mg, Al, K, Ca, Sc, Ti, and Fe. We find these abundances to be moderately supersolar, except …
Far From Their Origins: A Transcriptomic Investigation On How 2,4-Di-Tert-Butyl-6-(5-Chloro-2h-Benzotriazol-2-Yl) Phenol Affects Rainbow Trout Alevins, Andreas N.M. Eriksson, Justin Dubiel, Alper James Alcaraz, Jon A. Doering, Steve Wiseman
Far From Their Origins: A Transcriptomic Investigation On How 2,4-Di-Tert-Butyl-6-(5-Chloro-2h-Benzotriazol-2-Yl) Phenol Affects Rainbow Trout Alevins, Andreas N.M. Eriksson, Justin Dubiel, Alper James Alcaraz, Jon A. Doering, Steve Wiseman
Faculty Publications
Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to a variety of consumer (e.g., plastics) and industrial (e.g., metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention and only recently have been acknowledged to affect development and the endocrine system in vivo. In our previous study, altered behavior, indicative of potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected as embryos with a single environmentally relevant dose of 2,4-di-tert-butyl–6-(5-chloro-2H-benzotriazol-2-yl) phenol (UV-327). In the present follow-up study, we performed whole-transcriptome profiling (RNA sequencing) …
Discarded Vehicle Tires And Their Association With Mosquito Vector Abundance Across Socioenvironmental Gradients In New Orleans, La, Rebeca De Jesús Crespo, Alexandros Pavlakis, Jennifer Breaux, Claudia Riegel
Discarded Vehicle Tires And Their Association With Mosquito Vector Abundance Across Socioenvironmental Gradients In New Orleans, La, Rebeca De Jesús Crespo, Alexandros Pavlakis, Jennifer Breaux, Claudia Riegel
Faculty Publications
Discarded vehicle tires serve as habitat for mosquito vectors. In New Orleans, Louisiana, discarded tires are an increasingly important public concern, especially considering that the city is home to many medically important mosquito species. Discarded tires are known to be associated with mosquito abundance, but how their presence interacts with other socioenvironmental gradients to influence mosquito ecology is poorly understood. Here, we ask whether discarded tire distribution could be explained by social factors, particularly median income, home vacancy and human population density, and whether these factors interact with urban heat islands (UHI) to drive mosquito vector assemblages. We surveyed tire …
On The Injectivity Of The Shifted Funk–Radon Transform And Related Harmonic Analysis, Boris Rubin
On The Injectivity Of The Shifted Funk–Radon Transform And Related Harmonic Analysis, Boris Rubin
Faculty Publications
Necessary and sufficient conditions are obtained for injectivity of the shifted Funk–Radon transform associated with k-dimensional totally geodesic submanifolds of the unit sphere Sn in ℝn+1. This result generalizes the well known statement for the spherical means on Sn and is formulated in terms of zeros of Jacobi polynomials. The relevant harmonic analysis is developed, including a new concept of induced Stiefel (or Grassmannian) harmonics, the Funk–Hecke type theorems, addition formula, and multipliers. Some perspectives and conjectures are discussed.
Observations Of Low And Intermediate Spectral Peak Blazars With The Imaging X-Ray Polarimetry Explorer, Herman L. Marshall, Ioannis Liodakis, Alan P. Marscher, Niccolò Di Lalla, Svetlana G. Jorstad, Dawoon E. Kim, Riccardo Middei, Michela Negro, Nicola Omodei, Abel L. Peirson, Matteo Perri, Simonetta Puccetti, Marco Laurenti, Iván Agudo, Giacomo Bonnoli, Andrei V. Berdyugin, Elisabetta Cavazzuti, Nicole Rodriguez Cavero, Immacolata Donnarumma, Laura Di Gesu, Jenni Jormanainen, Henric Krawczynski, Elina Lindfors, Greg Madjeski, Frédéric Marin, Francesco Massaro, Luigi Pacciani, Juri Poutanen, Fabrizio Tavecchio, Pouya M. Kouch, Francisco José Aceituno, Maria I. Bernardos, Víctor Casanova
Observations Of Low And Intermediate Spectral Peak Blazars With The Imaging X-Ray Polarimetry Explorer, Herman L. Marshall, Ioannis Liodakis, Alan P. Marscher, Niccolò Di Lalla, Svetlana G. Jorstad, Dawoon E. Kim, Riccardo Middei, Michela Negro, Nicola Omodei, Abel L. Peirson, Matteo Perri, Simonetta Puccetti, Marco Laurenti, Iván Agudo, Giacomo Bonnoli, Andrei V. Berdyugin, Elisabetta Cavazzuti, Nicole Rodriguez Cavero, Immacolata Donnarumma, Laura Di Gesu, Jenni Jormanainen, Henric Krawczynski, Elina Lindfors, Greg Madjeski, Frédéric Marin, Francesco Massaro, Luigi Pacciani, Juri Poutanen, Fabrizio Tavecchio, Pouya M. Kouch, Francisco José Aceituno, Maria I. Bernardos, Víctor Casanova
Faculty Publications
We present X-ray polarimetry observations from the Imaging X-ray Polarimetry Explorer (IXPE) of three low spectral peak and one intermediate spectral peak blazars, namely 3C 273, 3C 279, 3C 454.3, and S5 0716+714. For none of these objects was IXPE able to detect X-ray polarization at the 3σ level. However, we placed upper limits on the polarization degree at ∼10%-30%. The undetected polarizations favor models where the X-ray band is dominated by unpolarized photons upscattered by relativistic electrons in the jets of blazars, although hadronic models are not completely eliminated. We discuss the X-ray polarization upper limits in the context …
Modification Of Childcare's Outdoor Setting For Toddler Physical Activity And Nature-Based Play: A Mixed Methods Study, Chelsea L. Kracht, Amanda E. Staiano, Melissa Harris, Kristin Domangue, Michelle Grantham-Caston
Modification Of Childcare's Outdoor Setting For Toddler Physical Activity And Nature-Based Play: A Mixed Methods Study, Chelsea L. Kracht, Amanda E. Staiano, Melissa Harris, Kristin Domangue, Michelle Grantham-Caston
Population and Public Health Science Faculty Publications
Background Toddler physical activity is critical for child health, but little is known about its applications in early childhood education (ECE) centers. The aims of this study were 1) to determine if pragmatic and nature-based modifications to an ECE center's outdoor setting were feasible and acceptable, and 2) to identify barriers and facilitators of toddler physical activity at ECE centers. Methods A multiphase mixed-methods study (QUANT+QUAL) was conducted. In the QUANT study, a stepped, sequential modification of the outdoor setting, using pragmatic and cost-effective nature-based elements, was conducted with a delayed control group over 10-weeks, with follow-up assessments 3-months later …
The Structure Of The Sufs–Sufe Complex Reveals Interactions Driving Protected Persulfide Transfer In Iron-Sulfur Cluster Biogenesis, Rajleen K. Gogar, Nidhi Chhikara, Minh Vo, Nathaniel C. Gilbert, Jack A. Dunkle, Patrick A. Frantom
The Structure Of The Sufs–Sufe Complex Reveals Interactions Driving Protected Persulfide Transfer In Iron-Sulfur Cluster Biogenesis, Rajleen K. Gogar, Nidhi Chhikara, Minh Vo, Nathaniel C. Gilbert, Jack A. Dunkle, Patrick A. Frantom
Faculty Publications
Fe-S clusters are critical cofactors for redox chemistry in all organisms. The cysteine desulfurase, SufS, provides sulfur in the SUF Fe-S cluster bioassembly pathway. SufS is a dimeric, pyridoxal 5'-phosphate-dependent enzyme that uses cysteine as a substrate to generate alanine and a covalent persulfide on an active site cysteine residue. SufS enzymes are activated by an accessory transpersulfurase protein, either SufE or SufU depending on the organism, which accepts the persulfide product and delivers it to downstream partners for Fe-S assembly. Here, using Escherichia coli proteins, we present the first X-ray crystal structure of a SufS/SufE complex. There is a …
Reconstructive Evolutionary Morphology: Tracing The Historical Process Of Modifications Of Complex Systems Driven By Natural Selection Through Changing Ecological Conditions, Dominique G. Homberger
Reconstructive Evolutionary Morphology: Tracing The Historical Process Of Modifications Of Complex Systems Driven By Natural Selection Through Changing Ecological Conditions, Dominique G. Homberger
Faculty Publications
There is general consensus among evolutionary biologists that natural selection drives phenotypic modifications within populations over generational time. How to reconstruct this historical process, however, has been discussed mostly in theoretical terms, and recommendations and explanations on how to translate such theoretical insights into practice are needed. The present study aims at providing a theory-supported practical guide on how to reconstruct historical evolutionary processes by applying a morphology-centered approach through a series of interdependent steps of descriptive morphology, functional analysis, ecological observation, integration of paleoecological data, and evolutionary synthesis. Special attention is given to the development of tests regarding the …
The K-Profile Parameterization Augmented By Deep Neural Networks (Kpp_Dnn) In The General Ocean Turbulence Model (Gotm), Jianguo Yuan, Jun Hong Liang, Eric P. Chassignet, Olmo Zavala-Romero, Xiaoliang Wan, Meghan F. Cronin
The K-Profile Parameterization Augmented By Deep Neural Networks (Kpp_Dnn) In The General Ocean Turbulence Model (Gotm), Jianguo Yuan, Jun Hong Liang, Eric P. Chassignet, Olmo Zavala-Romero, Xiaoliang Wan, Meghan F. Cronin
Faculty Publications
This study utilizes Deep Neural Networks (DNN) to improve the K-Profile Parameterization (KPP) for the vertical mixing effects in the ocean's surface boundary layer turbulence. The deep neural networks were trained using 11-year turbulence-resolving solutions, obtained by running a large eddy simulation model for Ocean Station Papa, to predict the turbulence velocity scale coefficient and unresolved shear coefficient in the KPP. The DNN-augmented KPP schemes (KPP_DNN) have been implemented in the General Ocean Turbulence Model (GOTM). The KPP_DNN is stable for long-term integration and more efficient than existing variants of KPP schemes with wave effects. Three different KPP_DNN schemes, each …
Preliminary Effectiveness Of A One-Week Summer Day Camp For Improving Children’S Health Behaviors And Psychosocial Well-Being Outcomes, Qiaoyin Tan, Yuxin Nie, Paul Son, Renee A. Underwood, Peyton Murray, Callie Hebert, K. Lynn Mckey, Chelsea Hendrick, Amanda E. Staiano, Senlin Chen
Preliminary Effectiveness Of A One-Week Summer Day Camp For Improving Children’S Health Behaviors And Psychosocial Well-Being Outcomes, Qiaoyin Tan, Yuxin Nie, Paul Son, Renee A. Underwood, Peyton Murray, Callie Hebert, K. Lynn Mckey, Chelsea Hendrick, Amanda E. Staiano, Senlin Chen
Faculty Publications
Purpose: Summer day camp offers children opportunities to grow knowledge and skills, be physically active, and have fun. Compared to healthy children, at-risk children (i.e., overweight, or with obesity and chronic health conditions) typically display less optimal health behaviors and psychosocial well-being, especially during summer months. This study examined the preliminary effectiveness of an American-Diabetes-Association-sponsored summer day camp at improving children’s health behaviors (i.e., physical activity, screen time, diet, sleep) and psychosocial well-being outcomes (i.e., quality of life [QoL], enjoyment, weight-related self-efficacy). Method: The sample consisted of 39 participants, including 19 boys and 20 girls, with majority being overweight (n …
Effects Of Intensive Treatment Of Chinese Women With Gestational Diabetes On The Risk Of Offspring Being Overweight From 3 To 8 Years Of Age, Jing Li, Rui Zhang, Cuiping Zhang, Gongshu Liu, Weiqin Li, Hui Wang, Yijuan Qiao, Zhijie Yu, Gang Hu, Juliana C.N. Chan, Junhong Leng, Xilin Yang
Effects Of Intensive Treatment Of Chinese Women With Gestational Diabetes On The Risk Of Offspring Being Overweight From 3 To 8 Years Of Age, Jing Li, Rui Zhang, Cuiping Zhang, Gongshu Liu, Weiqin Li, Hui Wang, Yijuan Qiao, Zhijie Yu, Gang Hu, Juliana C.N. Chan, Junhong Leng, Xilin Yang
Population and Public Health Science Faculty Publications
No abstract provided.
Trends In The Incidence Of Hypertensive Disorders Of Pregnancy Among The Medicaid Population Before And During Covid-19, Jessica Lin, Heidi Feng, Ronald Horswell, San Chu, Yun Shen, Gang Hu
Trends In The Incidence Of Hypertensive Disorders Of Pregnancy Among The Medicaid Population Before And During Covid-19, Jessica Lin, Heidi Feng, Ronald Horswell, San Chu, Yun Shen, Gang Hu
Population and Public Health Science Faculty Publications
Importance: Hypertensive disorders of pregnancy (HDP) are a group of high blood pressure disorders during pregnancy that are a leading cause of maternal and infant morbidity and mortality. Data on the trend in the incidence of HDP among the Medicaid population during coronavirus disease of 2019 (COVID-19) are lacking. Objective: To determine the trends in the annual incidence of HDP among pregnant Medicaid-insured women in Louisiana before and during the COVID-19 pandemic (2016–2021). Methods: A total of 113,776 pregnant women aged 15–50 years were included in this study. For multiparous individuals, only the first pregnancy was used in the analyses. …
Habitual Use Of Glucosamine And Adverse Liver Outcomes Among Patients With Type 2 Diabetes And Masld, Yun Shen, Yaxin Wang, Jingyi Lu, Yifei Mo, Xiaojing Ma, Gang Hu, Jian Zhou
Habitual Use Of Glucosamine And Adverse Liver Outcomes Among Patients With Type 2 Diabetes And Masld, Yun Shen, Yaxin Wang, Jingyi Lu, Yifei Mo, Xiaojing Ma, Gang Hu, Jian Zhou
Population and Public Health Science Faculty Publications
Background: Glucosamine is a dietary supplement commonly used to support joint health. However, there has been interest in exploring other effects of glucosamine on health outcomes due to its ant-inflammation effect. Objective: This study compared the risks of major adverse liver outcomes (MALOs) between regular users and non-users of glucosamine among patients with type 2 diabetes and metabolic dysfunction associated steatotic liver disease (MASLD) using the data from a large prospective cohort study. Methods: Demographic, anthropometric, laboratory and medication prescription information among 18 753 patients with type 2 diabetes and MASLD was obtained from the UK Biobank. MASLD was identified …
Temporal Scales Of Mass Wasting Sedimentation Across The Mississippi River Delta Front Delineated By 210pb/137cs Geochronology, Jeffrey Duxbury, Samuel J. Bentley, Kehui Xu, Navid H. Jafari
Temporal Scales Of Mass Wasting Sedimentation Across The Mississippi River Delta Front Delineated By 210pb/137cs Geochronology, Jeffrey Duxbury, Samuel J. Bentley, Kehui Xu, Navid H. Jafari
Faculty Publications
The Mississippi River Delta Front (MRDF) is a subaqueous apron of rapidly deposited and weakly consolidated sediment extending from the subaerial portions of the Birdsfoot Delta of the Mississippi River, long characterized by mass-wasting sediment transport. Four (4) depositional environments dominate regionally (an undisturbed topset apron, mudflow gully, mudflow lobe, and prodelta), centering around mudflow distribution initiated by a variety of factors (hurricanes, storms, and fluid pressure). To better understand the spatiotemporal scales of the events as well as the controlling processes, eight cores (5.8–8.0 m long) taken offshore from the South Pass (SP) and the Southwest Pass (SWP) were …
Application Of Surge Arrester In Limiting Voltage Stress At Direct Current Breaker, Mohammadamin Moghbeli, Shahab Mehraeen, Sudipta Sen
Application Of Surge Arrester In Limiting Voltage Stress At Direct Current Breaker, Mohammadamin Moghbeli, Shahab Mehraeen, Sudipta Sen
Faculty Publications
Hybrid DC circuit breakers combine mechanical switches with a redirecting current path, typically controlled by power electronic devices, to prevent arcing during switch contact separation. The authors’ past work includes a bipolar hybrid DC circuit breaker that effectively redirects the fault current and returns it to the source. This reduces arcing between the mechanical breaker’s contacts and prevents large voltage overshoots across them. However, the breaker’s performance declines as the upstream line inductance increases, causing overvoltage. This work introduces a modification to the originally proposed hybrid DC breaker to make it suitable to use anywhere along DC grid lines. By …
Insights From Augmented Data Integration And Strong Regularization In Drug Synergy Prediction With Synergnet, Mengmeng Liu, Gopal Srivastava, J. Ramanujam, Michal Brylinski
Insights From Augmented Data Integration And Strong Regularization In Drug Synergy Prediction With Synergnet, Mengmeng Liu, Gopal Srivastava, J. Ramanujam, Michal Brylinski
Faculty Publications
SynerGNet is a novel approach to predicting drug synergy against cancer cell lines. In this study, we discuss in detail the construction process of SynerGNet, emphasizing its comprehensive design tailored to handle complex data patterns. Additionally, we investigate a counterintuitive phenomenon when integrating more augmented data into the training set results in an increase in testing loss alongside improved predictive accuracy. This sheds light on the nuanced dynamics of model learning. Further, we demonstrate the effectiveness of strong regularization techniques in mitigating overfitting, ensuring the robustness and generalization ability of SynerGNet. Finally, the continuous performance enhancements achieved through the integration …
Advancing Hydrogen Gas Utilization In Industrial Boilers: Impacts On Critical Boiler Components, Mitigation Measures, And Future Perspectives, Edem Honu, Shengmin Guo, Shafiqur Rahman, Congyuan Zeng, Patrick Mensah
Advancing Hydrogen Gas Utilization In Industrial Boilers: Impacts On Critical Boiler Components, Mitigation Measures, And Future Perspectives, Edem Honu, Shengmin Guo, Shafiqur Rahman, Congyuan Zeng, Patrick Mensah
Faculty Publications
This review sets out to investigate the detrimental impacts of hydrogen gas (H2) on critical boiler components and provide appropriate state-of-the-art mitigation measures and future research directions to advance its use in industrial boiler operations. Specifically, the study focused on hydrogen embrittlement (HE) and high-temperature hydrogen attack (HTHA) and their effects on boiler components. The study provided a fundamental understanding of the evolution of these damage mechanisms in materials and their potential impact on critical boiler components in different operational contexts. Subsequently, the review highlighted general and specific mitigation measures, hydrogen-compatible materials (such as single-crystal PWA 1480E, Inconel 625, and …
Peak Microhardness Recovery Via T6 Heat Treatment With Extremely Soft Annealed Al7075 Feedstock In Additive Friction Stir Deposition, Huan Ding, Uttam Bhandari, Pengcheng Zhu, Ehsan Bagheri, Saeid Zavari, Yehong Chen, Yang Mu, Yongqiang Wang, Shengmin Guo
Peak Microhardness Recovery Via T6 Heat Treatment With Extremely Soft Annealed Al7075 Feedstock In Additive Friction Stir Deposition, Huan Ding, Uttam Bhandari, Pengcheng Zhu, Ehsan Bagheri, Saeid Zavari, Yehong Chen, Yang Mu, Yongqiang Wang, Shengmin Guo
Faculty Publications
With standard T6 heat treatments, precipitate-hardened alloys such as Al7075 and Al6061 fabricated using Additive Friction Stir Deposition (AFSD) method restore to noticeablely different peak mechanical properties. Previous research observed similar results but did not provide a viable solution. This study proposes a new processing strategy, namely enhanced plastic deformation by subjecting the Al7075 feedstock to annealed softening treatments. Specifically, by annealing the standard T651-Al7075 feedstock and deposition substrate (179 HV), their Microhardness were first degraded to its lowest state (80 HV), which is called a Soft-to-Soft system. For the Soft-to-Soft system subjected to AFSD, after undergoing appropriate T6 heat …
A Review Of Agrivoltaic Systems: Addressing Challenges And Enhancing Sustainability, Amro A. Zahrawi, Aly Mousaad Aly
A Review Of Agrivoltaic Systems: Addressing Challenges And Enhancing Sustainability, Amro A. Zahrawi, Aly Mousaad Aly
Faculty Publications
Agrivoltaics is a relatively new term used originally for integrating photovoltaic (PV) systems into the agricultural landscape and expanded to applications such as animal farms, greenhouses, and recreational parks. The dual use of land offers multiple solutions for the renewable energy sector worldwide, provided it can be implemented without negatively impacting agricultural production. However, agrivoltaics represent a relatively new technology, facing challenges including economic viability, vulnerability to wind loads, and interference with growing crops. This paper reviews the recent research on integrating agrivoltaics with farming applications, focusing on challenges, wind impact on agrivoltaics, and economic solutions. The effect of agrivoltaics …
An Intelligent Impulsive Noise Mitigation With Deep Learning Method, Guo Yang, Yuwen Qian, Zikun Wang, Xiangwei Zhou, Wen Wu
An Intelligent Impulsive Noise Mitigation With Deep Learning Method, Guo Yang, Yuwen Qian, Zikun Wang, Xiangwei Zhou, Wen Wu
Faculty Publications
To enable message transmission among sensors and equipment, power line communication (PLC) is a widely adopted smart grid. However, due to the occurrence of impulsive noise (IN), reliable transmissions over PLC channels in the smart grid are challenging. Therefore, in this paper, we propose an adaptive noise mitigation scheme to clip the IN with the sliding window-based method, where the altitude of the received signal in the current time slots is obtained by computing the average altitude of signals in the previous and next time slots. To detect the states of IN and dynamically estimate the power threshold of signals …
A Hermetic Package Technique For Multi-Functional Fiber Sensors Through Pressure Boundary Of Energy Systems Based On Glass Sealants, Zhichun Fan, Shuda Zhong, Kehao Zhao, Qirui Wang, Yuqi Li, Guangyin Zhang, Guangqun Ma, Jieru Zhao, He Yan, Zhiyong Huang, Jyotsna Sharma, Kevin P. Chen
A Hermetic Package Technique For Multi-Functional Fiber Sensors Through Pressure Boundary Of Energy Systems Based On Glass Sealants, Zhichun Fan, Shuda Zhong, Kehao Zhao, Qirui Wang, Yuqi Li, Guangyin Zhang, Guangqun Ma, Jieru Zhao, He Yan, Zhiyong Huang, Jyotsna Sharma, Kevin P. Chen
Faculty Publications
This paper presents a hermitic fiber sensor packaging technique that enables fiber sensors to be embedded in energy systems for performing multi-parameter measurements in high-temperature and strong radiation environments. A high-temperature stable Intrinsic Fabry–Perot interferometer (IFPI) array, inscribed by a femtosecond laser direct writing scheme, is used to measure both temperature and pressure induced strain changes. To address the large disparity in thermo-expansion coefficients (TECs) between silica fibers and metal parts, glass sealants with TEC between silica optical fibers and metals were used to hermetically seal optical fiber sensors inside stainless steel metal tubes. The hermetically sealed package is validated …
Geothermo-Mechanical Alterations Due To Heat Energy Extraction In Enhanced Geothermal Systems: Overview And Prospective Directions, Mary C. Ngoma, Oladoyin Kolawole, Olufemi Olorode
Geothermo-Mechanical Alterations Due To Heat Energy Extraction In Enhanced Geothermal Systems: Overview And Prospective Directions, Mary C. Ngoma, Oladoyin Kolawole, Olufemi Olorode
Faculty Publications
Geothermal energy from deep underground (or geological) formations, with or without its combination with carbon capture and storage (CCS), can be a key technology to mitigate anthropogenic greenhouse gas emissions and meet the 2050 net-zero carbon emission target. Geothermal resources in low-permeability and medium- and high-temperature reservoirs in sedimentary sequence require hydraulic stimulation for enhanced geothermal systems (EGS). However, fluid migration for geothermal energy in EGS or with potential CO2 storage in a CO2-EGS are both dependent on the in situ flow pathway network created by induced fluid injection. These thermo-mechanical interactions can be complex and induce varying alterations in …
The Effects Of The Atrial Natriuretic Peptide Deficiency On Renal Cortical Mitochondrial Bioenergetics In The Dahl Ss Rat, Alena Cherezova, Anastasia Sudarikova, Valeriia Vasileva, Regina Iurchenko, Anna Nikiforova, Denisha R. Spires, Aleksandra S. Zamaro, Adam C. Jones, Ryan S. Schibalski, Zheng Dong, Oleg Palygin, Krisztian Stadler, Daria V. Ilatovskaya
The Effects Of The Atrial Natriuretic Peptide Deficiency On Renal Cortical Mitochondrial Bioenergetics In The Dahl Ss Rat, Alena Cherezova, Anastasia Sudarikova, Valeriia Vasileva, Regina Iurchenko, Anna Nikiforova, Denisha R. Spires, Aleksandra S. Zamaro, Adam C. Jones, Ryan S. Schibalski, Zheng Dong, Oleg Palygin, Krisztian Stadler, Daria V. Ilatovskaya
Division of Basic Science Faculty Publications
Atrial Natriuretic Peptide (ANP) plays an important role in blood pressure regulation. Low levels of ANP correlate with the development of salt-sensitive hypertension (SS-HTN). Our previous studies indicated that ANP deficiency exacerbated renal function decline in SS-HTN. In the heart and fat tissue, ANP was reported to affect lipid peroxidation and mitochondrial bioenergetics but the effects of ANP on mitochondrial function in the kidney are unexplored. We hypothesized that ANP deficiency in SS-HTN causes renal bioenergetic shift, leading to disruption of mitochondrial network and oxidative stress. To address the hypothesis, we placed Dahl SS wild-type (SSWT) and ANP knockout (SSNPPA−/−) …
Vibrational Study Of Co, O2, And H2 Adsorbed On The Cocrfeni (110) High Entropy Alloy Surface, Frank Mckay, Andrew N. Okafor, David P. Young, Ye Xu, Phillip T. Sprunger
Vibrational Study Of Co, O2, And H2 Adsorbed On The Cocrfeni (110) High Entropy Alloy Surface, Frank Mckay, Andrew N. Okafor, David P. Young, Ye Xu, Phillip T. Sprunger
Faculty Publications
The vibrational properties of CO, O2, and H2 molecularly or dissociatively adsorbed on a CoCrFeNi(110) surface have been probed using high-resolution energy loss spectroscopy (HREELS) and modeled using density functional theory (DFT) calculations. Large (∼20 mm3) single-crystal, quaternary face-centered cubic CoCrFeNi was synthesized via a modified Czochralski technique. We show strong evidence that CO adsorbs primarily on bridge and on-top sites in compositionally varied local environments, which reflect the random, multielemental surface composition inherent in a high entropy alloy. A variation of adsorption sites is also found with oxygen, which exhibits two broad groups of modes. Comparison to previous photoemission …