Digital Commons Network^™

Inductor Free Methods For Breaking Dc Currents, Sudipta Sen

LSU Doctoral Dissertations

The current interruption in dc circuits is more difficult to achieve compared to the ac circuits because, unlike ac systems, dc circuits do not have the natural current zero-crossing. Presently there are three categories of basic dc breaker models namely mechanical, static, and hybrid dc breakers. As current power systems is moving more towards microgrids, DERs, Electric Vehicles (EVs), and with recent advancements in dc circuits, wide verities of dc power sources, and loads, dc breakers are very important in future system protection.

New alternate methods to break dc currents for low-voltage applications are proposed in this work. The proposed …

Gut Microbiota Composition And Predicted Microbial Metabolic Pathways Of Obesity Prone And Obesity Resistant Outbred Sprague-Dawley Cd Rats May Account For Differences In Their Phenotype, Diana N. Obanda, Michael J. Keenan, Ryan Page, Anne M. Raggio, Christopher M. Taylor, Brian D. Marx, Rhett W. Stout, Justin Guice, Meng Luo, David A. Welsh, Diana Coulon, Claudia Husseneder

Faculty Publications

Like humans, outbred Sprague-Dawley CD rats exhibit a polygenic pattern of inheritance of the obese phenotype and not all individuals exposed to a high calorie intake develop obesity. We hypothesized that differences in gut microbiota composition account for phenotype differences between obese prone (OP) and obese resistant (OR) rats. We studied the gut microbiota composition of OPand OR rats after a high fat (HF) diet and how they respond to fermentation of resistant starch (RS). In phase 1 of the study 28 OP and 28 OR rats were fed a HF diet. In order to determine causal role of microbiota …

Hypothalamic Steroid Receptor Coactivator-2 Regulates Adaptations To Fasting And Overnutrition, Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu

Division of Basic Science Faculty Publications

The neuroendocrine system coordinates metabolic and behavioral adaptations to fasting, including reducing energy expenditure, promoting counterregulation, and suppressing satiation and anxiety to engage refeeding. Here, we show that steroid receptor coactivator-2 (SRC-2) in pro-opiomelanocortin (POMC) neurons is a key regulator of all these responses to fasting. POMC-specific deletion of SRC-2 enhances the basal excitability of POMC neurons; mutant mice fail to efficiently suppress energy expenditure during food deprivation. SRC-2 deficiency blunts electric responses of POMC neurons to glucose fluctuations, causing impaired counterregulation. When food becomes available, these mutant mice show insufficient refeeding associated with enhanced satiation and discoordination of anxiety …

Shark Side Of The Moon: Are Shark Attacks Related To Lunar Phase?, Lindsay A. French, Stephen R. Midway, David H. Evans, George H. Burgess

Faculty Publications

Animals across taxa have shown behaviors linked to moon phase (or the proxy of lunar illumination), and marine organisms are well-documented to calibrate certain activities with the moon. Few studies have looked at a possible connection between moon phase and shark attacks on humans, and the results have been preliminary or lacking relationships. We used nearly 50 years of shark attack data from across the globe to test for a relationship between shark attacks and moon phase. We examined factors of geography, shark species, and outcome of attack. From 12 relationships that we tested (totaling 120 comparisons), we found 12 …

Non-Local Corrections To The Typical Medium Theory Of Anderson Localization, H. Terletska, A. Moilanen, K. M. Tam, Y. Zhang, Y. Wang, M. Eisenbach, N. S. Vidhyadhiraja, L. Chioncel, J. Moreno

Faculty Publications

We use the recently developed finite cluster typical medium approach to study the Anderson localization transition in three dimensions. Applying our method to the box and binary alloy disorder distributions, we find a fast convergence with the cluster size. We demonstrate the importance of the typical medium environment and the non-local spatial correlations for the proper characterization of the localization transition. As the cluster size increases, our typical medium cluster method recovers the correct critical disorder strength for the transition. Our findings highlight the importance of the non-local cluster corrections for capturing the localization behavior of the mobility edge trajectories. …

Degradative Tubular Lysosomes Link Pexophagy To Starvation And Early Aging In C. Elegans, D A. Dolese, M P. Junot, B Ghosh, T J. Butsch, D A. Dolese, K A. Bohnert

Faculty Publications

Organelle-specific autophagy directs degradation of eukaryotic organelles under certain conditions. Like other organelles, peroxisomes are subject to autophagic turnover at lysosomes. However, peroxisome autophagy (pexophagy) has yet to be analyzed in a live-animal system, limiting knowledge on its regulation during an animal's life. Here, we generated a tandem-fluorophore reporter that enabled real-time tracking of pexophagy in live Caenorhabditis elegans. We observed that pexophagy occurred at a population of non-canonical, tubular lysosomes specifically during starvation and aging. Remarkably, in these contexts, tubular lysosomes were the predominant type of lysosome in the intestine, transforming from vesicles. Though we found that peroxisomes were …

Scalable Multiphoton Quantum Metrology With Neither Pre- Nor Post-Selected Measurements, Chenglong You, Mingyuan Hong, Peter Bierhorst, Adriana E. Lita, Scott Glancy, Steve Kolthammer, Emanuel Knill, Sae Woo Nam, Richard P. Mirin, Omar S. Magaña-Loaiza, Thomas Gerrits

Faculty Publications

The quantum statistical fluctuations of electromagnetic fields establish a limit, known as the shot-noise limit, on the sensitivity of optical measurements performed with classical technologies. However, quantum technologies are not constrained by this shot-noise limit. In this regard, the possibility of using every photon produced by quantum sources of light to estimate small physical parameters, beyond the shot-noise limit, constitutes one of the main goals of quantum optics. Here, we experimentally demonstrate a scalable protocol for quantum-enhanced optical phase estimation across a broad range of phases, with neither pre- nor post-selected measurements. This is achieved through the efficient design of …

Immune-Related Genes Of The Larval Holotrichia Parallela In Response To Entomopathogenic Nematodes Heterorhabditis Beicherriana Lf, Ertao Li, Jianhui Qin, Honglin Feng, Jinqiao Li, Xiaofeng Li, Innocent Nyamwasa, Yazhong Cao, Weibin Ruan, Kebin Li, Jiao Yin

Faculty Publications

Background: Entomopathogenic nematodes (EPNs) emerge as compatible alternatives to conventional insecticides in controlling Holotrichia parallela larvae (Coleoptera: Scarabaeidae). However, the immune responses of H. parallela against EPNs infection remain unclear. Results: In present research, RNA-Seq was firstly performed. A total of 89,427 and 85,741 unigenes were achieved from the midgut of H. parallela larvae treated with Heterorhabditis beicherriana LF for 24 and 72 h, respectively; 2545 and 3156 unigenes were differentially regulated, respectively. Among those differentially expressed genes (DEGs), 74 were identified potentially related to the immune response. Notably, some immune-related genes, such as peptidoglycan recognition protein SC1 (PGRP-SC1), pro-phenoloxidase …

Association Between Particulate Matter Containing Epfrs And Neutrophilic Asthma Through Ahr And Th17, Jeffrey N. Harding, Maureen Gross, Vivek Patel, Steven Potter, Stephania A. Cormier

Division of Basic Science Faculty Publications

Background: Epidemiological data associate high levels of combustion-derived particulate matter (PM) with deleterious respiratory outcomes, but the mechanism underlying those outcomes remains elusive. It has been acknowledged by the World Health Organization that PM exposure contributes to more than 4.2 million all-cause mortalities worldwide each year. Current literature demonstrates that PM exacerbates respiratory diseases, impairs lung function, results in chronic respiratory illnesses, and is associated with increased mortality. The proposed mechanisms revolve around oxidative stress and inflammation promoting pulmonary physiological remodeling. However, our previous data found that PM is capable of inducing T helper cell 17 (Th17) immune responses via …

Accelerated Functional Brain Aging In Pre-Clinical Familial Alzheimer’S Disease, Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Martin Farlow, Serge Gauthier, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, John C.S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Michael Weiner, Howard J. Rosen, Bruce L. Miller, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter

Clinical Research Faculty Publications

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the …

Weight Loss In Primary Care: A Pooled Analysis Of Two Pragmatic Cluster-Randomized Trials, Peter T. Katzmarzyk, John W. Apolzan, Byron Gajewski, William D. Johnson, Corby K. Martin, Robert L. Newton, Michael G. Perri, Jeffrey J. Vanwormer, Christie A. Befort

Clinical Research Faculty Publications

Objective: The aim of this study was to report the results of five weight-loss interventions in primary care settings in underserved patients and to compare the level of pragmatism across the interventions using the Pragmatic Explanatory Continuum Indicator Summary (PRECIS-2) tool. Methods: Data from 54 primary care clinics (2,210 patients) were pooled from the Promoting Successful Weight Loss in Primary Care in Louisiana (PROPEL) and Rural Engagement in Primary Care for Optimizing Weight Reduction (REPOWER) cluster-randomized trials. Clinics were randomized to one of five comparators: PROPEL usual care, PROPEL combination of in-clinic and telephone visits, REPOWER in-clinic individual visits, REPOWER …

On The Role Of Matrix-Weights Elements In Consensus Algorithms For Multi-Agent Systems, Joshua Ogbebor, Xiangyu Meng

Faculty Publications

This paper examines the roles of the matrix weight elements in matrix-weighted consensus. The consensus algorithms dictate that all agents reach consensus when the weighted graph is connected. However, it is not always the case for matrix weighted graphs. The conditions leading to different types of consensus have been extensively analysed based on the properties of matrix-weighted Laplacians and graph theoretic methods. However, in practice, there is concern on how to pick matrix-weights to achieve some desired consensus, or how the change of elements in matrix weights affects the consensus algorithm. By selecting the elements in the matrix weights, different …

Experimental Investigation Of The Aerodynamics Of A Large Industrial Building With Parapet, Aly Mousaad Aly, Matthew Thomas, Hamzeh Gol-Zaroudi

Faculty Publications

The aerodynamic performance of a roof depends significantly on its shape and size, among other factors. For instance, large roofs of industrial low-rise buildings may behave differently compared to those of residential homes. The main objective of this study is to experimentally investigate how perimeter solid parapets can alter the flow pattern around a low-rise building with a large aspect ratio of width/height of about 7.6, the case of industrial buildings/shopping centers. Solid parapets of varied sizes are added to the roof and tested in an open-jet simulator in a comparative study to understand their impact on roof pressure coefficients. …

Bridge Load Posting Prediction, Sabarethinam Kameshwar, Md. Manik Mia, Sai Bandaru

Publications

There are approximately 13,000 bridges in Louisiana facilitating movement of people, goods, and services. At present, about 12% of the bridges are load posted, i.e., they are deemed to lack the strength to safely carry all legal loads. With time bridges will age and deteriorate; at the same time, legal loads might increase. Load posted bridges disrupt the movement of goods and commerce. Therefore, objective of this research was to estimate the number of load posted bridges in Louisiana over the next 50 years. For this purpose, herein, a data based approach was used. For a given bridge type, the …

Protein Kinase Sgk2 Is Induced By The Β3 Adrenergic Receptor-Camp-Pka-Pgc-1Α/Nt-Pgc-1Α Axis But Dispensable For Brown/Beige Adipose Tissue Thermogenesis, Chul Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang

Division of Basic Science Faculty Publications

Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes remains unraveled. Here, we examined the regulation and role of Sgk2 in brown/beige adipose tissue thermogenesis. We found that transcriptional coactivators PGC-1α and NT-PGC-1α activated by the β3 adrenergic receptor-cAMP-PKA pathway are recruited to the Sgk2 promoter, triggering Sgk2 transcription in response to cold. SGK2 elevation was closely associated with increased serine/threonine phosphorylation of proteins carrying the consensus RxRxxS/T phosphorylation site. However, despite cold-dependent …

The Use Of Rna Interference To Investigate The Role Of Zmpr10 In Salt Stress Response And Mtl/Nld/Zmpla1 In The Improvement Of Haploid Induction In Maize, Max Carl Miller

LSU Master's Theses

RNA interference (RNAi) is a useful tool in gene characterization and its use is expanding into more practical fields. Two RNAi techniques were used in this case. The studies conducted in the chapter two use transgenic maize lines containing an RNAi construct targeting ZmPR10 to characterize its potential role in growth and development in response to salinity stress. T₁ transgenic plants from events A44S1-35-3 and A44S1-3-4, which had significantly reduced ZmPR10 expression compared to the non-transgenic controls, showed no differences compared to the controls in heights after 30 and 60 days, nor did the T₂ transgenic from these …

Characteristics And Causal Factors For The Receptive-Expressive Gap In Typically Developed Spanish-English Adult Bilinguals, Rachael Janelle Javaherian

LSU Master's Theses

A receptive-expressive language gap occurs when a standardized receptive score is statistically greater than an expressive score in either a primary or a second language. In bilingual children, gap studies already exist for determining language impairment. In adults, there are few studies; nevertheless, one needs to distinguish between typical language patterns of bilingualism due to non-pathological loss of L1 skills versus problems resulting from accidents, disease, or age. To this end, the present study attempted to expand findings of studies by Gibson et al. (2012 and 2014) that focused on analysis of the gap and possible factors influencing its existence …

Cfd Simulations Of Macroscopic And Microscopic Multiphase Fluid Flow And Droplet Interaction, Aaron Harrington

LSU Master's Theses

Multiphase flow is a complex phenomenon which can be modeled on numerous different length scales, both macroscopically and microscopically. The use of a Euler-Euler model for Computation Fluid Dynamics (CFD) simulations of subcooled boiling phenomena is discussed in detail. The CFD conditions have been set up to mimic previous experimental conditions. A cylindrical vessel with subcooled liquid flow is heated along part of the axial wall of the vessel. A constant heat flux is applied to produce subcooled boiling. We discuss the development of the phase change within the vessel as well as the temperature profile, and validate the results …

Crystallization-Driven Self-Assembly Of Coil-Comb Shaped Polypeptoid Block Copolymers: Controlling The Growth Of One-Dimensional Nanostructures, Md Asmat Ullah

LSU Master's Theses

Poly-peptoid based nanoparticles have gained much attention concerning applications in biotechnology or biomedicine due to their biocompatibility and biodegradability. However, the controlled growth of colloidally stable polypeptoid nanostructures of uniform size and controlled geometry remains a major challenge. In this study, the crystallization driven self-assembly (CDSA) of amphiphilic polypeptoid diblock co-polymers, namely poly (N-methyl glycine)-b-poly (N-decyl glycine) (PNMG-b-PNDG), was investigated for the growth of one-dimensional (1D) nanostructures in solution. PNMG-b-PNDG block copolymers (M₉₈D₂₀) were synthesized by sequential benzyl amine-initiated ring-opening polymerizations of the corresponding N-substituted glycine derived N-carboxy anhydrides, in which the degree of …

Investigation Of Bovine Herpesvirus-1 Determinants Of Neuronal Infectivity In Novel Bovine Neuronal Cell Systems For Development Of A Safer Viral Vaccine Vector, Jared Rudd

LSU Doctoral Dissertations

Bovine herpesvirus-1 (BoHV-1) is the causative agent of infectious bovine rhinotracheitis and a component of the bovine respiratory disease complex. BoHV-1 is a significant burden on the cattle industry in the United States causing severe respiratory disease, abortions, loss of calves (“shipping fever”). BoHV-1 belongs to the alphaherpesvirus subfamily of Herpesviridae. Alphaherpesviruses enter axons of sensory nerves and establish life-long latency in trigeminal and dorsal root ganglionic neurons after primary infection of the oronasal or genital epithelium respectively. Modified live attenuated vaccines for BoHV-1 are commercially available but are limited in their protection while retaining the ability to establish latency …

An Investigation Examining The Closing Of The Achievement Gap In Louisiana With The Ngss, George Cage

LSU Doctoral Dissertations

The purpose of this study was to investigate the Next Generation Science Standards (NGSS) and its implications of being a curricular and pedagogical intervention in terms of narrowing the achievement gap in science education for Children of Color. In using the explanatory mixed methods design, standardized test data and one-on-one interviews were examined to assess the effectiveness and impact of the NGSS’ implementation in the state of Louisiana. This study utilized student performance results from the LEAP 2025 to conduct a statistical analysis that measured trends in performance by Children of Color, specifically Black students, before and after the implementation …

Responses Of Wetland Soil Microbial Communities To Different Types Of Anthropogenic Stress, Grace Ann Cagle

LSU Doctoral Dissertations

Microorganisms are the major drivers of biogeochemical transformations of carbon and nitrogen in wetlands. These processes are crucial for ecological sustainability and are heavily impacted by human activities. How anthropogenic stress affects the microbial drivers of carbon storage and nutrient cycling in wetlands is not well understood. I investigated the response of wetland soil microbial communities to three different types of anthropogenic stress using DNA sequencing. First, I studied the effect of warming on microbial carbon processing in a peatland underlaid by permafrost by comparing the abundances of specific genes between sites subjected to five years of warming and controls. …

Role Of Aim2 Inflammasome In Pulmonary Host Defense Against Staphylococcus Aureus-Induced Pneumonia, Bibek Dhakal

LSU Master's Theses

Bacterial pneumonia is the leading cause of death in children under the age of five, claiming the lives of two million children each year. Staphylococcus aureus is the extracellular Gram-positive bacteria that causes necrotizing pneumonia. Moreover, the spread of antibiotic-resistant and hypervirulent strains has made treatment more challenging. Absent in melanoma 2 (AIM2) is a dsDNA-sensing cytosolic innate immune receptor that activates inflammasomes and is crucial for host defense against intracellular bacteria and DNA viruses. However, its role in extracellular bacterial pathogen-induced pneumonia is unclear. Therefore, understanding how AIM2 initiates host responses during Staphylococcus aureus is crucial for the development …

Developing A Watershed-Based Plan Evaluation Framework For Socio-Ecological Network Analysis In The Upper Pontchartrain Basin, Lindsey R. Lamana

LSU Master's Theses

Louisiana's efforts to create regional watershed planning under the Louisiana Watershed Initiative (LWI) suggest the need to evaluate existing governance systems such as the coordination, development, and implementation of plans. The Network Analysis and Plan Evaluation (NAPE) Framework developed in this study answers initial questions related to the LWI’s long-term resilience outcomes from the content analysis and extraction of relational data in plans of LWI Region 7 located in the Upper Pontchartrain Basin. Actor-Plan Coordination Networks reveal the coordination and collaboration of entities, and a Network of Plans presents the integration of planning documents in the Region. Local government organizations …

Metal Fatigue And Crack Propagation Using Thermodynamic/Thermoelectric Approach, Behnam Hajshirmohammadi

LSU Doctoral Dissertations

The present dissertation concentrates on the fatigue life of metals and fatigue crack growth (FCG). The basic concept of fatigue thermodynamics is used for this purpose. With the application of thermoelectricity, a method is developed on the basis of fracture fatigue entropy (FFE) for the rapid estimation of the fatigue life of components. To this end, thermoelectric signals captured from a specimen during cyclic loading are analyzed, and a procedure is proposed for the calculation of fatigue life based on the thermoelectric signals in the beginning and the steady-state zone of fatigue. Temperature gradient and electric potential gradients in metals …

De Finetti’S Theorem In Categorical Probability, Tobias Fritz, Tomáš Gonda, Paolo Perrone

Journal of Stochastic Analysis

No abstract provided.

Insights Into Abscisic Acid And Phosphatidic Acid Signal Transduction Dynamics In Arabidopsis Thaliana, Ruth Wanjiru Ndathe

LSU Doctoral Dissertations

Abscisic acid (ABA) is a plant hormone that triggers a signaling transduction in response to drought, salinity, and cold. The core components in the ABA signaling pathway that lead to downstream ABA responses have been identified.

Phosphatidic acid (PA) is a membrane phospholipid that is involved in the signaling pathway for ABA-induced stomatal closure. We tested whether PA is involved in the signaling pathway for ABA-induced gene expression as well, using model plant Arabidopsis thaliana. We selected the RD29A gene which is a canonical drought gene that is induced by ABA. We found that PA is not involved in …

Genetic Structuring And Community Assembly In Neotropical Birds, Oscar Johnson

LSU Doctoral Dissertations

The factors that influence how species form is of fundamental interest to biology. Under the framework of the speciation cycle, the process begins by population subdivision creating structured populations that then diverge until two new species form. Following speciation, however, continued divergence is necessary for these new species to be able to coexist without adverse interactions, known as the transition to secondary sympatry. At this point the speciation cycle is complete and the process can begin anew. Many of the factors influencing these processes remain poorly understood. Here, I explore the factors that influence speciation and community assembly in Neotropical …

Temperature Affects The Time Required To Discern The Relationship Between Primary Production And Export Production In The Ocean, Edward Laws, Kanchan Maiti

Faculty Publications

No abstract provided.

Temperature Affects The Time Required To Discern The Relationship Between Primary Production And Export Production In The Ocean, Edward Laws, Kanchan Maiti

Faculty Publications

No abstract provided.