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The African Light Source: History, Context And Future, Simon H. Connell, Kathleen Dollman, Gihan Kamel, Sameen A. Khan, Edward Mitchell, Sekazi K. Mtingwa, Marcus C. Newton, Prosper Ngabonziza, Emmanuel Nji, Lawrence Norris, Michele Zema Jan 2024

The African Light Source: History, Context And Future, Simon H. Connell, Kathleen Dollman, Gihan Kamel, Sameen A. Khan, Edward Mitchell, Sekazi K. Mtingwa, Marcus C. Newton, Prosper Ngabonziza, Emmanuel Nji, Lawrence Norris, Michele Zema

Faculty Publications

The African Light Source (AfLS) project is now almost eight years old. This article assesses the history, current context and future of the project. There is by now considerable momentum in building the user community, including deep training, facilitating access to current facilities, growing the scientific output, scientific networks and growing the local laboratory-scale research infrastructure. The Conceptual Design Report for the AfLS is in its final editing stages. This document specifies the socio-economic and scientific rationales and the technical aspects amongst others. The AfLS is supported by many national and Pan-African scientific professional bodies and voluntary associates across many …

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Right-Angled Artin Subgroups Of Right-Angled Coxeter And Artin Groups, Pallavi Dani, Ivan Levcovitz Jan 2024

Right-Angled Artin Subgroups Of Right-Angled Coxeter And Artin Groups, Pallavi Dani, Ivan Levcovitz

Faculty Publications

We determine when certain natural classes of subgroups of right-angled Coxeter groups (RACGs) and right-angled Artin groups (RAAGs) are themselves RAAGs. We characterize finite-index visual RAAG subgroups of 2–dimensional RACGs. As an application, we show that any 2–dimensional, one-ended RACG with planar defining graph is quasi-isometric to a RAAG if and only if it is commensurable to a RAAG. Additionally, we give new examples of RACGs with nonplanar defining graphs which are commensurable to RAAGs. Finally, we give a new proof of a result of Dyer: every subgroup generated by conjugates of RAAG generators is itself a RAAG.

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Phosphatidic Acid Produced By Phospholipase Dα1 And Dδ Is Incorporated Into The Internal Membranes But Not Involved In The Gene Expression Of Rd29a In The Abscisic Acid Signaling Network In Arabidopsis Thaliana, Ruth Ndathe, Naohiro Kato Jan 2024

Phosphatidic Acid Produced By Phospholipase Dα1 And Dδ Is Incorporated Into The Internal Membranes But Not Involved In The Gene Expression Of Rd29a In The Abscisic Acid Signaling Network In Arabidopsis Thaliana, Ruth Ndathe, Naohiro Kato

Faculty Publications

Core protein components of the abscisic acid (ABA) signaling network, pyrabactin resistance (PYR), protein phosphatases 2C (PP2C), and SNF1-related protein kinase 2 (SnRK2) are involved in the regulation of stomatal closure and gene expression downstream responses in Arabidopsis thaliana. Phosphatidic acid (PA) produced by the phospholipases Dα1 and Dδ (PLDs) in the plasma membrane has been identified as a necessary molecule in ABA-inducible stomatal closure. On the other hand, the involvement of PA in ABA-inducible gene expression has been suggested but remains a question. In this study, the involvement of PA in the ABA-inducible gene expression was examined in the …

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Feature Engineering Of Environmental Covariates Improves Plant Genomic-Enabled Prediction, Osval A. Montesinos-López, Leonardo Crespo-Herrera, Carolina Saint Pierre, Bernabe Cano-Paez, Gloria Isabel Huerta-Prado, Brandon Alejandro Mosqueda-González, Sofia Ramos-Pulido, Guillermo Gerard, Khalid Alnowibet, Roberto Fritsche-Neto, Abelardo Montesinos-López, José Crossa Jan 2024

Feature Engineering Of Environmental Covariates Improves Plant Genomic-Enabled Prediction, Osval A. Montesinos-López, Leonardo Crespo-Herrera, Carolina Saint Pierre, Bernabe Cano-Paez, Gloria Isabel Huerta-Prado, Brandon Alejandro Mosqueda-González, Sofia Ramos-Pulido, Guillermo Gerard, Khalid Alnowibet, Roberto Fritsche-Neto, Abelardo Montesinos-López, José Crossa

Faculty Publications

Introduction: Because Genomic selection (GS) is a predictive methodology, it needs to guarantee high-prediction accuracies for practical implementations. However, since many factors affect the prediction performance of this methodology, its practical implementation still needs to be improved in many breeding programs. For this reason, many strategies have been explored to improve the prediction performance of this methodology. Methods: When environmental covariates are incorporated as inputs in the genomic prediction models, this information only sometimes helps increase prediction performance. For this reason, this investigation explores the use of feature engineering on the environmental covariates to enhance the prediction performance of genomic …

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Ba5sb8: The Highest Homologue Of The Family Of Binary Semiconducting Barium Antimonides Bansb2n−2 (N ≥ 2), S. M.Gayomi K. Samarakoon, Alexander Ovchinnikov, Sviatoslav Baranets, Svilen Bobev Jan 2024

Ba5sb8: The Highest Homologue Of The Family Of Binary Semiconducting Barium Antimonides Bansb2n−2 (N ≥ 2), S. M.Gayomi K. Samarakoon, Alexander Ovchinnikov, Sviatoslav Baranets, Svilen Bobev

Faculty Publications

A novel binary compound within the Ba–Sb phase diagram, Ba5Sb8, was synthesized by combining elements with an excess of Sb in an alumina crucible. Structural elucidation was performed using single-crystal X-ray diffraction. This compound crystallizes in the orthorhombic space group Fdd2 with unit cell parameters of a = 15.6568(13) Å, b = 35.240(3) Å, c = 6.8189(6) Å, adopting its own structure type. The most distinctive features of the structure are the eight-membered [Sb8]10− polyanionic fragments which have no known precedents among antimonides. They are separated by five Ba2+ cations, which afford the charge balance and enable adherence …

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Enriched Molecular-Level View Of Saline Wetland Soil Carbon By Sensitivity-Enhanced Solid-State Nmr, Wancheng Zhao, Elizabeth C. Thomas, Debkumar Debnath, Faith J. Scott, Frederic Mentink-Vigier, John R. White, Robert L. Cook, Tuo Wang Jan 2024

Enriched Molecular-Level View Of Saline Wetland Soil Carbon By Sensitivity-Enhanced Solid-State Nmr, Wancheng Zhao, Elizabeth C. Thomas, Debkumar Debnath, Faith J. Scott, Frederic Mentink-Vigier, John R. White, Robert L. Cook, Tuo Wang

Faculty Publications

Soil organic matter (SOM) plays a major role in mitigating greenhouse gas emission and regulating earth’s climate, carbon cycle, and biodiversity. Wetland soils account for one-third of all SOM; however, globally, coastal wetland soils are eroding faster due to increasing sea-level rise. Our understanding of carbon sequestration dynamics in wetlands lags behind that of upland soils. Here, we employ solid-state nuclear magnetic resonance (ssNMR) to investigate the molecular-level structure of biopolymers in wetland soils spanning 11 centuries. High-resolution multidimensional spectra, enabled by dynamic nuclear polarization (DNP), demonstrate enduring preservation of molecular structures within herbaceous plant cores, notably condensing aromatic motifs …

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Modelling And Simulation Of The Cholesteric Landau-De Gennes Model, Andrew L. Hicks, Shawn W. Walker Jan 2024

Modelling And Simulation Of The Cholesteric Landau-De Gennes Model, Andrew L. Hicks, Shawn W. Walker

Faculty Publications

This paper discusses modelling and numerical issues in the simulation of the Landau-de Gennes (LdG) model of nematic liquid crystals (LCs) with cholesteric effects. We propose a fully implicit, (weighted) L2 gradient flow for computing energy minimizers of the LdG model, and note a time-step restriction for the flow to be energy decreasing. Furthermore, we give a mesh size restriction, for finite-element discretizations, that is critical to avoid spurious numerical artifacts in discrete minimizers, particularly when simulating cholesteric LCs that exhibit 'twist.' Furthermore, we perform a computational exploration of the model and present several numerical simulations in three dimensions, on …

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Lsu General Catalog 2024-2025, Louisiana State University And Agricultural And Mechanical College Jan 2024

Lsu General Catalog 2024-2025, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

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Afbnet: A Lightweight Adaptive Feature Fusion Module For Super-Resolution Algorithms, Lirong Yin, Lei Wang, Siyu Lu, Ruiyang Wang, Haitao Ren, Ahmed Alsanad, Salman A. Alqahtani, Zhengtong Yin, Xiaolu Li, Wenfeng Zheng Jan 2024

Afbnet: A Lightweight Adaptive Feature Fusion Module For Super-Resolution Algorithms, Lirong Yin, Lei Wang, Siyu Lu, Ruiyang Wang, Haitao Ren, Ahmed Alsanad, Salman A. Alqahtani, Zhengtong Yin, Xiaolu Li, Wenfeng Zheng

Faculty Publications

At present, super-resolution algorithms are employed to tackle the challenge of low image resolution, but it is difficult to extract differentiated feature details based on various inputs, resulting in poor generalization ability. Given this situation, this study first analyzes the features of some feature extraction modules of the current super-resolution algorithm and then proposes an adaptive feature fusion block (AFB) for feature extraction. This module mainly comprises dynamic convolution, attention mechanism, and pixel-based gating mechanism. Combined with dynamic convolution with scale information, the network can extract more differentiated feature information. The introduction of a channel spatial attention mechanism combined with …

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Afterword: Moses And The Modern Germans: The Lawgiver In A Philhellenic Age, Suzanne Marchand Jan 2024

Afterword: Moses And The Modern Germans: The Lawgiver In A Philhellenic Age, Suzanne Marchand

Faculty Publications

No abstract provided.

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Revisiting The Notion Of Vicarious Cause: Allure, Metaphor, And Realism In Object-Oriented Ontology, Jon Cogburn, Niki Young Jan 2024

Revisiting The Notion Of Vicarious Cause: Allure, Metaphor, And Realism In Object-Oriented Ontology, Jon Cogburn, Niki Young

Faculty Publications

We revisit the notion of vicarious causation in Graham Harman's Object-Oriented Ontology (OOO) in order to first show that Harman has articulated two iterations of his account that are in tension with one another; one is found in his earlier paper "On Vicarious Causation,"while the other is contained in his later writings following the publication of Object-Oriented Ontology: A New Theory of Everything. This involves a critical assessment of his developing theory of metaphor in a way that encourages sympathetic revision in the service of improving his non-correlationist view of intra-objective relations.

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Differential Measurement Error In House Price Indices, Darren Hayunga, R. Kelley Pace, Shuang Zhu, Raffaella Calabrese Jan 2024

Differential Measurement Error In House Price Indices, Darren Hayunga, R. Kelley Pace, Shuang Zhu, Raffaella Calabrese

Faculty Publications

This article investigates measurement errors when using indices to model house prices over time. Our analysis, comparing index prices to actual transaction values, reveals that in many cases, widely-used indices display measurement errors correlated with the index values. Measurement error correlated with predictors constitutes “differential measurement error” at the level of the data generating process (DGP). We further explore the presence of differential measurement error within the context of mortgage lending. Our findings uncover substantial measurement errors in mortgage data, which not only diminish the predictive accuracy of models but also introduce notable biases in the coefficient estimates of variables.

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The Incompatibility Of The Commons And The Public, Roy L. Heidelberg Jan 2024

The Incompatibility Of The Commons And The Public, Roy L. Heidelberg

Faculty Publications

In this essay I consider the conceptual conflict between the public as a modern political category and the idea of the commons. By linking the idea of the public to an early exposition that explicitly sought a distinction between the commons and the public, I show how the generalization inherent in the public contravenes the particularity of the commons. This poses important political problems for how a modern commons or a modern notion of the commons is conceived and also allows for a nuanced understanding of the political challenge posed against the commons itself.

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The Aftermath Of The 2019 Pulwama Terror Attack–Religion, Nationalism And Exclusion In Online News Comment Sections, Nihar Sreepada, Ioana Coman Jan 2024

The Aftermath Of The 2019 Pulwama Terror Attack–Religion, Nationalism And Exclusion In Online News Comment Sections, Nihar Sreepada, Ioana Coman

Faculty Publications

This study analyses the Indian and Pakistani publics reactions of the extensive coverage of the Pulwama terror attack, through an analysis of the online comments appearing at the end of the news stories covering the attack from the two leading English newspapers: Times of India (TOI) (India), and Dawn (D) (Pakistan). A qualitative content analysis is performed to compare and examine this dialogue emerging in the news comments sections. Findings are explored and discussed through conceptualizations of religion, nationalism, and a social psychological perspective towards exclusion of out-groups.

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Subject Pronoun Expression In Andean Colombian Spanish: The Preseea-Cali Corpus, Rafael Orozco, Margareth Marmolejo Caicedo, Róbinson Grajales Jan 2024

Subject Pronoun Expression In Andean Colombian Spanish: The Preseea-Cali Corpus, Rafael Orozco, Margareth Marmolejo Caicedo, Róbinson Grajales

Faculty Publications

This preliminary investigation explores subject pronoun expression in the PRESEEA-Cali corpus. We explore the effects of five predictor variables (2 social 3 linguistic) on 4425 tokens. Findings reveal the highest pronominal rate (29.7%) found in a continental Latin American speech community. The linguistic conditioning uncovers that grammatical person and number of the subject exerts the strongest conditioning force among all the predictor variables explored. Specifically, uno constitutes the pronoun that most strongly favors overt subjects. The social conditioning reveals that women promote overt subjects, as occurs in the Caribbean region, but contrary to findings in Medellín. Moreover, the effects of …

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Negotiating Quotidian Justice In The Science Classroom, Christopher Irwin, Joshua Ellis Jan 2024

Negotiating Quotidian Justice In The Science Classroom, Christopher Irwin, Joshua Ellis

Faculty Publications

In this conceptual paper, we explore how science teachers might enact social justice through their everyday science instruction. Drawing on empirical literature and our own K-12 teaching experience, we develop a heuristic for mapping classroom discourses to engage in action and reflection to change both the world of the classroom community, and the world beyond the school. We suggest how this heuristic can be used for justice-oriented science teaching independently of (or as a supplement to) any existing frameworks for science teaching to promote social justice. Our proposed model for social justice through disciplinary science teaching frames justice not as …

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Accelerating L-Shaped Two-Stage Stochastic Scuc With Learning Integrated Benders Decomposition, Fouad Hasan, Amin Kargarian Jan 2024

Accelerating L-Shaped Two-Stage Stochastic Scuc With Learning Integrated Benders Decomposition, Fouad Hasan, Amin Kargarian

Faculty Publications

Benders decomposition is widely used to solve large mixed-integer problems. This article takes advantage of machine learning and proposes a variant of Benders decomposition to tackle two-stage stochastic security-constrained unit commitment (SCUC). The problem is decomposed into a master problem (MP) and subproblems (SPs) corresponding to individual load scenarios. The primary objective is to mitigate computational expenses and memory consumption associated with Benders decomposition by generating tighter cuts and reducing the MP's dimensions. A regressor reads load profile scenarios and predicts objective function proxy values for the SPs, enabling the creation of tighter cuts for the MP. The numerical difference …

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Optimizing Privacy And Utility Tradeoffs For Group Interests Through Harmonization, Bishwas Mandal, George Amariucai, Shuangqing Wei Jan 2024

Optimizing Privacy And Utility Tradeoffs For Group Interests Through Harmonization, Bishwas Mandal, George Amariucai, Shuangqing Wei

Faculty Publications

We propose a novel problem formulation to address the privacy-utility tradeoff, specifically when dealing with two distinct user groups characterized by unique sets of private and utility attributes. Unlike previous studies that primarily focus on scenarios where all users share identical private and utility attributes and often rely on auxiliary datasets or manual annotations, we introduce a collaborative data-sharing mechanism between two user groups through a trusted third party. This third party uses adversarial privacy techniques with our proposed data-sharing mechanism to internally sanitize data for both groups and eliminates the need for manual annotation or auxiliary datasets. Our methodology …

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The Economics Of Privacy And Utility: Investment Strategies, Chandra Sharma, George Amariucai, Shuangqing Wei Jan 2024

The Economics Of Privacy And Utility: Investment Strategies, Chandra Sharma, George Amariucai, Shuangqing Wei

Faculty Publications

The inevitable leakage of privacy as a result of unrestrained disclosure of personal information has motivated extensive research on robust privacy-preserving mechanisms. However, existing research is mostly limited to solving the problem in a static setting with disregard for the privacy leakage over time. Unfortunately, this treatment of privacy is insufficient in practical settings where users continuously disclose their personal information over time resulting in an accumulated leakage of the users' sensitive information. In this paper, we consider privacy leakage over a finite time horizon and investigate optimal strategies to maximize the utility of the disclosed data while limiting the …

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Evaluating The Moisture Susceptibility Of Asphalt Mixes In Oklahoma, Mohamed Elkashef, Samir Ahmed, Sina Mousavi Rad Jan 2024

Evaluating The Moisture Susceptibility Of Asphalt Mixes In Oklahoma, Mohamed Elkashef, Samir Ahmed, Sina Mousavi Rad

Publications

Moisture-induced damage can be detrimental to asphalt pavements. The modified Lottman approach (AASHTO T 283) is used to evaluate the stripping susceptibility of mixtures in Oklahoma. There are concerns about the ability of the AASHTO 283 to predict moisture damage in the field. In this study, the AASHTO T 283, the moisture-induced stress tester (MiST), and the Hamburg wheel tracking (HWT) test are used to evaluate the moisture susceptibility of mixes prepared using different gradations, local aggregate sources, and binders sampled from different refineries in Oklahoma. The mixes were also tested for cracking and rutting using the indirect tensile asphalt …

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Green Mobility In Texas: Comparative Environmental Impacts And Lifecycle Cost Analysis Of Hybrid, Electric, And Hydrogen Fuel Cell Cars, Raghava R. Kommalapati, Hongbo Du, Md Jobair Bin Alam Jan 2024

Green Mobility In Texas: Comparative Environmental Impacts And Lifecycle Cost Analysis Of Hybrid, Electric, And Hydrogen Fuel Cell Cars, Raghava R. Kommalapati, Hongbo Du, Md Jobair Bin Alam

Publications

Compared to gasoline/diesel cars and battery electric cars (BECs), hydrogen fuel cell cars (HFCCs) are relatively new. Two main advantages of HFCCs over electric vehicles are no special requirements for heavy batteries and long charging time. There is no HFCC in Texas; thus, exploring the use of electricity or hydrogen produced from renewable energies for personal cars and mitigating vehicle emissions is critical for sustaining a long-term decarburization strategy for megacities like Houston and Dallas. This project addressed this critical gap and developed environmental impacts and cost assessments for hybrid gasoline cars, BECs, and HFCCs in Texas under several possible …

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Motorcycle Crash Analysis, Hatim Sharif, Samer Dessouky Jan 2024

Motorcycle Crash Analysis, Hatim Sharif, Samer Dessouky

Publications

The Fatality Analysis Reporting System database shows that, in stark contrast to the 34 percent decline in non-motorcyclist crash–related fatalities, motorcyclist crash–related fatalities were up 86 percent with only three year-to-year declines since 1997, while non-motorcyclist crash–related fatalities had 13 year-to-year declines since 1997. At the national level, the rate of motorcyclist fatalities per vehicle mile traveled is 29 times higher than the rate among passenger car occupants, with overall injury rates approximately five times higher among motorcyclists than passenger car occupants. Given the frequency of motorcycle crashes and their staggering toll in terms of loss of life and economic …

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Quantization Of Spherically Symmetric Loop Quantum Gravity Coupled To A Scalar Field And A Clock: The Asymptotic Limit, Rodolfo Gambini, Jorge Pullin Dec 2023

Quantization Of Spherically Symmetric Loop Quantum Gravity Coupled To A Scalar Field And A Clock: The Asymptotic Limit, Rodolfo Gambini, Jorge Pullin

Faculty Publications

We continue our work on the study of spherically symmetric loop quantum gravity coupled to two spherically symmetric scalar fields, one which acts as a clock. As a consequence of the presence of the latter, we can define a true Hamiltonian for the theory. The spherically symmetric context allows to carry out precise detailed calculations. Here we study the theory for regions of large values of the radial coordinate. This allows us to define in detail the vacuum of the theory and study its quantum states, yielding a quantum field theory on a quantum space time that makes contact with …

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Mixed Method Study On Community College Instruction In Blended Social Science Courses, Andrea L. B. Eggenberger Dec 2023

Mixed Method Study On Community College Instruction In Blended Social Science Courses, Andrea L. B. Eggenberger

LSU Doctoral Dissertations

Community colleges have teaching faculty whose primary focus is educating their students and providing service to their institution. Community college teaching research has focused on innovation, students’ expectations, and the use of active learning techniques to foster student success. Research on blended courses has focused on instructional practices, learner engagement, and the benefits of blended learning for the community college student population. This study explores the relationship between student’s perceptions of the work in a blended developmental psychology course at two community colleges in Louisiana and their professors’ instructional decisions for their blended courses. The multiple-case study uses a convergent …

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Creelcat, A Catalog Of United States Inland Creel And Angler Survey Data, Nicholas A. Sievert, Abigail J. Lynch, Holly S. Embke, Ashley Robertson, Mitchel Lang, Anna L. Kaz, Matthew D. Robertson, Stephen R. Midway, Lyndsie Wszola, Craig P. Paukert Dec 2023

Creelcat, A Catalog Of United States Inland Creel And Angler Survey Data, Nicholas A. Sievert, Abigail J. Lynch, Holly S. Embke, Ashley Robertson, Mitchel Lang, Anna L. Kaz, Matthew D. Robertson, Stephen R. Midway, Lyndsie Wszola, Craig P. Paukert

Faculty Publications

The United States Inland Creel and Angler Survey Catalog (CreelCat) contains a national compilation of angler and creel survey data collected by natural resource management agencies across the United States (including Washington, D.C. and Puerto Rico). These surveys are used to help inform the management of recreational fisheries, by collecting information about anglers including what they are catching and harvesting, the amount of effort they expend, their angling preferences, and demographic information. As of May 1, 2023, CreelCat houses over 14,729 surveys from 33 states, Puerto Rico, and Washington, D.C., comprising 235 data fields across 8 tables. These tables contain …

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A Repeated-Measures Study Of Relational Turbulence And Transition Processing Communication During The Summer Of Covid-19 (Summer 2020), Kellie St Cyr Brisini, Denise Haunani Solomon Dec 2023

A Repeated-Measures Study Of Relational Turbulence And Transition Processing Communication During The Summer Of Covid-19 (Summer 2020), Kellie St Cyr Brisini, Denise Haunani Solomon

Faculty Publications

Drawing upon relational turbulence theory and the experiencing life transitions model, this study examined communication and relationship qualities as married couples experienced work-family changes during the COVID-19 pandemic. Sixty-four American married, different-sex partners affected by job-related changes due to COVID-19 reported their relationship qualities and their own and their spouse’s engagement in transition processing communication weekly for 10 weeks. Hypotheses addressed associations between relationship qualities and communication experiences both averaged across the 10 weeks and indexed by within-week deviations from those averages, controlling for the previous week’s reports. Husbands’ and wives’ own attempts—and also their perceptions of their spouse’s attempts—to …

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Sensory Spinal Interoceptive Pathways And Energy Balance Regulation, Heike Münzberg, Hans Rudolf Berthoud, Winfried L. Neuhuber Dec 2023

Sensory Spinal Interoceptive Pathways And Energy Balance Regulation, Heike Münzberg, Hans Rudolf Berthoud, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

Interoception plays an important role in homeostatic regulation of energy intake and metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain signaling via vagal sensory nerves and hormones, such as leptin. However, signaling via spinal sensory neurons is rapidly emerging as an additional important signaling pathway. Here we provide an in-depth review of the known anatomy and functions of spinal sensory pathways and discuss potential mechanisms relevant for energy balance homeostasis in health and disease. Because sensory innervation by dorsal root ganglia (DRG) neurons goes far beyond vagally innervated viscera and includes adipose tissue, skeletal muscle, and skin, it …

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Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch Dec 2023

Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch

Faculty Publications

Aquatic biomedical model organisms play a substantial role in advancing our understanding of human health, however, comparably little work has been directed towards developing dependable, high-throughput storage programs for valuable genetic resources. The Zebrafish International Resource Center (ZIRC) has developed a standardized cryopreservation pathway and stored thousands of genetic lines in their repository for use by the biomedical research community. This has yet to be replicated in other facilities, and an overall repository-level pathway has never been analyzed for aquatic species. To encourage repository development for other biomedical models and to improve the ZIRC storage process and system, this study …

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Physiologic Hormone Administration Improves Hba1c In Native Americans With Type 2 Diabetes: A Retrospective Study And Review Of Insulin Secretion And Action, Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway Dec 2023

Physiologic Hormone Administration Improves Hba1c In Native Americans With Type 2 Diabetes: A Retrospective Study And Review Of Insulin Secretion And Action, Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway

Clinical Research Faculty Publications

Insulin is secreted in pulses from pancreatic beta-cells, and these oscillations maintain fasting plasma glucose levels within a narrow normal range. Within islets, beta-cells exhibit tight synchronization of regular oscillations. This control circuit is disrupted in type 2 diabetes, and irregularities in pulse frequency and amplitude occur. The prevalence of type 2 diabetes is three times higher in American Indian and Native Alaskans compared to Whites, and their genetic ancestry is associated with low beta-cell function. Obesity in this population compounds their vulnerability to adverse outcomes. The purpose of this article is to review insulin secretion and action and its …

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Acute Exercise Increases Nk Cell Mitochondrial Respiration And Cytotoxicity Against Triple-Negative Breast Cancer Cells Under Hypoxic Conditions, Eunhan Cho, James Stampley, Rachel Wall, Rachel Matthews, Elizabeth Zunica, Justin C. Brown, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann Dec 2023

Acute Exercise Increases Nk Cell Mitochondrial Respiration And Cytotoxicity Against Triple-Negative Breast Cancer Cells Under Hypoxic Conditions, Eunhan Cho, James Stampley, Rachel Wall, Rachel Matthews, Elizabeth Zunica, Justin C. Brown, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann

Clinical Research Faculty Publications

Purpose Triple-negative breast cancer (TNBC) is an aggressive, highly metastatic malignancy with high recurrence rates. Hypoxia is a hallmark of the TNBC tumor microenvironment, which promotes tumor growth while impairing natural killer (NK) cell cytotoxic functions. Although acute exercise improves NK cell function under normoxic conditions, the effect of exercise on NK cell cytotoxic functions under hypoxic conditions mimicking O2 tensions observed in solid tumors is unknown. Methods The cytotoxic functions of resting and postexercise NK cells isolated from thirteen young inactive healthy women were assessed against breast cancer cells expressing different levels of hormone receptors (MCF-7 and MDA-MB-231) under …

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