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Louisiana Agriculture Spring, 2010, Lsu Agcenter Apr 2010

Louisiana Agriculture Spring, 2010, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

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Symbiosis In Subterranean Termites: A Review Of Insights From Molecular Studies, Claudia Husseneder Apr 2010

Symbiosis In Subterranean Termites: A Review Of Insights From Molecular Studies, Claudia Husseneder

Faculty Publications

The symbiotic relationship of termites and their eukaryotic and prokaryotic gut microbiota is a focal point of research because of the important roles symbionts play in termite nutrition. The use of molecular methods has recently provided valuable insights into the species diversity and the roles of microorganisms in the guts of termites. This paper provides a review of the current knowledge of symbiont species inventories, genome analysis, and gene expression in the guts of subterranean termites. Particular emphasis is given to the termite genera Reticulitermes and Coptotermes (Isoptera: Rhinotermitidae), because they contain pest species of global impact in their native …

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Fleshing Out The Spirit Of Contention: Conflicting Preventative Approaches To The Aids Pandemic In Africa And The Promise Of A Scientific Narrative, Rachel Zimmerman Apr 2010

Fleshing Out The Spirit Of Contention: Conflicting Preventative Approaches To The Aids Pandemic In Africa And The Promise Of A Scientific Narrative, Rachel Zimmerman

Honors Capstones

No abstract provided.

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Hatchability Of End-Of-Lay Broiler Breeder Eggs As Influenced By Cooling During Incubation, James Rabalais Apr 2010

Hatchability Of End-Of-Lay Broiler Breeder Eggs As Influenced By Cooling During Incubation, James Rabalais

Honors Capstones

No abstract provided.

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Strict Lyapunov Function Constructions Under Lasalle Conditions With An Application To Lotka-Volterra Systems, Frédéric Mazenc, Michael Malisoff Apr 2010

Strict Lyapunov Function Constructions Under Lasalle Conditions With An Application To Lotka-Volterra Systems, Frédéric Mazenc, Michael Malisoff

Faculty Publications

We provide new techniques for building explicit global strict Lyapunov functions for broad classes of periodic time varying nonlinear systems satisfying LaSalle conditions. We illustrate our work using the Lotka-Volterra model, which plays a fundamental role in bioengineering. We use our strict Lyapunov constructions to prove robustness of the Lotka-Volterra tracking dynamics to uncertainty in the death rates. © 2006 IEEE.

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Antibacterial Activity Of Chitosans With Different Degrees Of Deacetylation And Viscosities, Eun Ju Jung, Dal Kyoung Youn, Shin Ho Lee, Hong Kyoon No, Jong Gill Ha, Witoon Prinyawiwatkul Apr 2010

Antibacterial Activity Of Chitosans With Different Degrees Of Deacetylation And Viscosities, Eun Ju Jung, Dal Kyoung Youn, Shin Ho Lee, Hong Kyoon No, Jong Gill Ha, Witoon Prinyawiwatkul

Faculty Publications

Antibacterial activities of six acid-soluble [two degrees of deacetylation (DD) × three viscosities] and two water-soluble chitosans (two DD with similar viscosities) were examined against eight gram-negative (Pseudomonas fluorescens, Proteus vulgaris, Erwinia carotovora, Serratia marcescens, Escherichia coli, Vibrio parahaemolyticus, V. vulnificus, and Salmonella Typhimurium) and six gram-positive bacteria (Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis, B. cereus, Lactobacillus curvatus, and L. plantarum). Antibacterial activities of chitosans differed depending on the chitosan types and bacteria tested. Water-soluble chitosans inhibited bacterial growth by one to eight log cycles at 0.1% concentration; however, the effects were much lesser than those observed with 0.05% acid-soluble …

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A Dynamic Physical Model For Soil Temperature And Water In Taylor Valley, Antarctica, H. W. Hunt, A. G. Fountain, P. T. Doran, H. Basagic Apr 2010

A Dynamic Physical Model For Soil Temperature And Water In Taylor Valley, Antarctica, H. W. Hunt, A. G. Fountain, P. T. Doran, H. Basagic

Faculty Publications

We developed a simulation model for terrestrial sites including sensible heat exchange between the atmosphere and ground surface, inter- and intra-layer heat conduction by rock and soil, and shortwave and longwave radiation. Water fluxes included snowmelt, freezing/thawing of soil water, soil capillary flow, and vapour flows among atmosphere, soil, and snow. The model accounted for 96-99% of variation in soil temperature data. No long-term temporal trends in soil temperature were apparent. Soil water vapour concentration in thawed surface soil in summer often was higher than in frozen deeper soils, leading to downward vapour fluxes. Katabatic winds caused a reversal of …

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Lessons Learned From Nature: The Sweet Way To Preserve Cells, Shhyam Moorthy Apr 2010

Lessons Learned From Nature: The Sweet Way To Preserve Cells, Shhyam Moorthy

Honors Capstones

No abstract provided.

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Increasing Lipoxygenase Solubility Through Fusion Of Highly Acidic Peptides, Rachel Fabacher Apr 2010

Increasing Lipoxygenase Solubility Through Fusion Of Highly Acidic Peptides, Rachel Fabacher

Honors Capstones

No abstract provided.

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Interactions Of The High Mobility Group Box Homolog 2 With Distorted Duplex Dna, Wedad Rahman Mar 2010

Interactions Of The High Mobility Group Box Homolog 2 With Distorted Duplex Dna, Wedad Rahman

Honors Capstones

No abstract provided.

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Faculty Senate Resolution 10-03, Louisiana State University And Agricultural & Mechanical College Mar 2010

Faculty Senate Resolution 10-03, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Faculty Senate Resolution on replacing the current system of appointments with a new system of elections for members of the Graduate Council, adopted on March 15, 2010.

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Potential For Misidentification Of Environmentally Persistent Free Radicals As Molecular Pollutants In Particulate Matter, Hieu Truong, Slawo Lomnicki, Barry Dellinger Mar 2010

Potential For Misidentification Of Environmentally Persistent Free Radicals As Molecular Pollutants In Particulate Matter, Hieu Truong, Slawo Lomnicki, Barry Dellinger

Faculty Publications

Environmentally persistent free radicals (EPFRs) have been shown to form on the surfaces of various types of transition metal-containing particulate matter (PM), and it has been demonstrated they are capable of initiating adverse health impacts. Following sonification and solvent extraction for chemical analysis, they are partially converted to molecular species. Alcoholic solvents extracted the EPFRs with near 100% efficiency, while nonpolar hydrocarbon solvents exhibited < 20% efficiency and dichloromethane exhibited 20-55% efficiency. The extracted radicals reacted in solution to form multiple molecular reaction products including catechol, hydroquinone, phenol, chlorinated phenols, dibenzo-p-dioxin, and dibenzofuran. This suggests that EPFRs in environmental samples are indistinguishable from molecular pollutants and are subject to misidentification as molecular adsorbates when traditional extraction and chemical analysis methods are employed. On the basis of these findings, the origin of the toxicity of particulate matter contaminated with toxic organic compounds should be considered for re-evaluation to include the possibility that EPFRs may be a significant contributor, and the impact of some molecular pollutants may have been overestimated. © 2010 American Chemical Society.

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In Vitro And In Vivo Assessment Of Pulmonary Risk Associated With Exposure To Combustion Generated Fine Particles, Baher Fahmy, Liren Ding, Dahui You, Slawo Lomnicki, Barry Dellinger, Stephania A. Cormier Mar 2010

In Vitro And In Vivo Assessment Of Pulmonary Risk Associated With Exposure To Combustion Generated Fine Particles, Baher Fahmy, Liren Ding, Dahui You, Slawo Lomnicki, Barry Dellinger, Stephania A. Cormier

Faculty Publications

Strong correlations exist between exposure to PM2.5 and adverse pulmonary effects. PM2.5 consists of fine (≤2.5μm) and ultrafine (≤0.1μm) particles with ultrafine particles accounting for >70% of the total particles. Environmentally persistent free radicals (EPFRs) have recently been identified in airborne PM2.5. To determine the adverse pulmonary effects of EPFRs associated with exposure to elevated levels of PM2.5, we engineered 2.5μm surrogate EPFR-particle systems. We demonstrated that EPFRs generated greater oxidative stress in vitro, which was partly responsible for the enhanced cytotoxicity following exposure. In vivo studies using rats exposed to EPFRs containing particles demonstrated minimal adverse pulmonary effects. Additional …

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Mechanisms Of Apoptosis In Crustacea: What Conditions Induce Versus Suppress Cell Death?, Michael A. Menze, Grady Fortner, Suman Nag, Steven C. Hand Mar 2010

Mechanisms Of Apoptosis In Crustacea: What Conditions Induce Versus Suppress Cell Death?, Michael A. Menze, Grady Fortner, Suman Nag, Steven C. Hand

Faculty Publications

Arthropoda is the largest of all animal phyla and includes about 90% of extant species. Our knowledge about regulation of apoptosis in this phylum is largely based on findings for the fruit fly Drosophila melanogaster. Recent work with crustaceans shows that apoptotic proteins, and presumably mechanisms of cell death regulation, are more diverse in arthropods than appreciated based solely on the excellent work with fruit flies. Crustacean homologs exist for many major proteins in the apoptotic networks of mammals and D. melanogaster, but integration of these proteins into the physiology and pathophysiology of crustaceans is far from complete. Whether apoptosis …

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Monitoring And First Discovery Of The Mexican Rice Borer Eoreuma Loftini (Lepidoptera: Crambidae) In Louisiana, N. A. Hummel, T. Hardy, T. E. Reagan, D. Pollet, C. Carlton, M. J. Stout, J. M. Beuzelin, W. Akbar, W. White Mar 2010

Monitoring And First Discovery Of The Mexican Rice Borer Eoreuma Loftini (Lepidoptera: Crambidae) In Louisiana, N. A. Hummel, T. Hardy, T. E. Reagan, D. Pollet, C. Carlton, M. J. Stout, J. M. Beuzelin, W. Akbar, W. White

Faculty Publications

Eoreuma loftini has expanded its range from the LRGV to east Texas, and now into southwest Louisiana. LDAF and LSU AgCenter scientists forecast that natural and unintended artificial movement will result in the continued spread of E. loftini toward the heart of Louisiana's rice and sugarcane-growing regions. The 12-XII-2008 collection was the first confirmation of this pest in the state. By catching E. loftini early in its natural advancement into Louisiana, additional rapid and proactive responses will allow producers to become educated on the best management practices for the pest in sugarcane and rice. These best management practices include planting …

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Biological Control Of Tropical Soda Apple (Solanaceae) In Florida: Post-Release Evaluation, J. Medal, N. Bustamante, W. Overholt, R. Diaz, P. Stansly, A. Roda, D. Amalin, K. Hibbard, R. Gaskalla, B. Sellers, S. Hight, J. Cuda Mar 2010

Biological Control Of Tropical Soda Apple (Solanaceae) In Florida: Post-Release Evaluation, J. Medal, N. Bustamante, W. Overholt, R. Diaz, P. Stansly, A. Roda, D. Amalin, K. Hibbard, R. Gaskalla, B. Sellers, S. Hight, J. Cuda

Faculty Publications

The leaf feeding beetle Gratiana boliviana was released on tropical soda apple plants in Sumter County, FL., in 2006. The beetles significantly defoliated the plants over the period of the summers of 2006 and 2007, and became well established in the area.

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When Trees Grow Too Long: Investigating The Causes Of Highly Inaccurate Bayesian Branch-Length Estimates, Jeremy M. Brown, Shannon M. Hedtke, Alan R. Lemmon, Emily Moriarty Lemmon Mar 2010

When Trees Grow Too Long: Investigating The Causes Of Highly Inaccurate Bayesian Branch-Length Estimates, Jeremy M. Brown, Shannon M. Hedtke, Alan R. Lemmon, Emily Moriarty Lemmon

Faculty Publications

A surprising number of recent Bayesian phylogenetic analyses contain branch-length estimates that are several orders of magnitude longer than corresponding maximum-likelihood estimates. The levels of divergence implied by such branch lengths are unreasonable for studies using biological data and are known to be false for studies using simulated data. We conducted additional Bayesian analyses and studied approximate-posterior surfaces to investigate the causes underlying these large errors. We manipulated the starting parameter values of the Markov chain Monte Carlo (MCMC) analyses, the moves used by the MCMC analyses, and the prior-probability distribution on branch lengths. We demonstrate that inaccurate branch-length estimates …

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Evaluations Of A Novel Isolate Of Isaria Fumosorosea For Control Of The Asian Citrus Psyllid, Diaphorina Citri (Hemiptera: Psyllidae), Marjorie A. Hoy, Raghuwinder Singh, Michael E. Rogers Mar 2010

Evaluations Of A Novel Isolate Of Isaria Fumosorosea For Control Of The Asian Citrus Psyllid, Diaphorina Citri (Hemiptera: Psyllidae), Marjorie A. Hoy, Raghuwinder Singh, Michael E. Rogers

Faculty Publications

A fungal pathogen that killed adult Diaphorina citri Kuwayama (Asian citrus psyllid) in Florida citrus groves was isolated, characterized molecularly and morphologically and identified as a novel isolate of Isaria fumosorosea (Ifr) (= Paecilomyces fumosoroseus) from the Asian citrus psyllid (Ifr AsCP), but no concentration-mortality or time-response data were obtained. When adult psyllids were sprayed with spores at 28°C, time response (LT50) values of 111 and 102.5 h at spore concentrations of 1 × 107 and 1 × 108 spores/mL, respectively, were obtained. The LT99, was 167.4 and 174.6 h, respectively, for the 2 spore concentrations. After 192 h, the …

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Response To Calcium Channel Blocker Therapy In Black Hypertensive Patients, Thu T. Nguyen, Jay S. Kaufman, Richard S. Cooper Mar 2010

Response To Calcium Channel Blocker Therapy In Black Hypertensive Patients, Thu T. Nguyen, Jay S. Kaufman, Richard S. Cooper

Faculty Publications

No abstract provided.

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Rapid Assessment Of Genetic Ancestry In Populations Of Unknown Origin By Genome-Wide Genotyping Of Pooled Samples, Charleston W.K. Chiang, Zofia K.Z. Gajdos, Joshua M. Korn, Finny G. Kuruvilla, Johannah L. Butler, Rachel Hackett, Candace Guiducci, Thutrang T. Nguyen, Rainford Wilks, Terrence Forrester, Christopher A. Haiman, Katherine D. Henderson, Loic Le Marchand, Brian E. Henderson, Mark R. Palmert, Colin A. Mckenzie, Helen N. Lyon, Richard S. Cooper, Xiaofeng Zhu, Joel N. Hirschhorn Mar 2010

Rapid Assessment Of Genetic Ancestry In Populations Of Unknown Origin By Genome-Wide Genotyping Of Pooled Samples, Charleston W.K. Chiang, Zofia K.Z. Gajdos, Joshua M. Korn, Finny G. Kuruvilla, Johannah L. Butler, Rachel Hackett, Candace Guiducci, Thutrang T. Nguyen, Rainford Wilks, Terrence Forrester, Christopher A. Haiman, Katherine D. Henderson, Loic Le Marchand, Brian E. Henderson, Mark R. Palmert, Colin A. Mckenzie, Helen N. Lyon, Richard S. Cooper, Xiaofeng Zhu, Joel N. Hirschhorn

Faculty Publications

As we move forward from the current generation of genome-wide association (GWA) studies, additional cohorts of different ancestries will be studied to increase power, fine map association signals, and generalize association results to additional populations. Knowledge of genetic ancestry as well as population substructure will become increasingly important for GWA studies in populations of unknown ancestry. Here we propose genotyping pooled DNA samples using genome-wide SNP arrays as a viable option to efficiently and inexpensively estimate admixture proportion and identify ancestry informative markers (AIMs) in populations of unknown origin. We constructed DNA pools from African American, Native Hawaiian, Latina, and …

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Structural Studies Of Bacterioferritin B From Pseudomonas Aeruginosa Suggest A Gating Mechanism For Iron Uptake Via The Ferroxidase Center, Saroja K. Weeratunga, Scott Lovell, Huili Yao, Kevin P. Battaile, Christopher J. Fischer, Casey E. Gee, Mario Rivera Feb 2010

Structural Studies Of Bacterioferritin B From Pseudomonas Aeruginosa Suggest A Gating Mechanism For Iron Uptake Via The Ferroxidase Center, Saroja K. Weeratunga, Scott Lovell, Huili Yao, Kevin P. Battaile, Christopher J. Fischer, Casey E. Gee, Mario Rivera

Faculty Publications

The structure of recombinant Pseudomonas aeruginosa bacterioferritin B (Pa BfrB) has been determined from crystals grown from protein devoid of core mineral iron (as-isolated) and from protein mineralized with ≃600 iron atoms (mineralized). Structures were also obtained from crystals grown from mineralized BfrB after they had been soaked in an FeSO4 solution (Fe soak) and in separate experiments after they had been soaked in an FeSO 4 solution followed by a soak in a crystallization solution (double soak). Although the structures consist of a typical bacterioferritin fold comprised of a nearly spherical 24-mer assembly that binds 12 heme molecules, comparison …

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Development And Verification Of An Analytical Algorithm To Predict Absorbed Dose Distributions In Ocular Proton Therapy Using Monte Carlo Simulations, Nicholas C. Koch, Wayne D. Newhauser Feb 2010

Development And Verification Of An Analytical Algorithm To Predict Absorbed Dose Distributions In Ocular Proton Therapy Using Monte Carlo Simulations, Nicholas C. Koch, Wayne D. Newhauser

Faculty Publications

Proton beam radiotherapy is an effective and non-invasive treatment for uveal melanoma. Recent research efforts have focused on improving the dosimetric accuracy of treatment planning and overcoming the present limitation of relative analytical dose calculations. Monte Carlo algorithms have been shown to accurately predict dose per monitor unit (D/MU) values, but this has yet to be shown for analytical algorithms dedicated to ocular proton therapy, which are typically less computationally expensive than Monte Carlo algorithms. The objective of this study was to determine if an analytical method could predict absolute dose distributions and D/MU values for a variety of treatment …

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A Duplicate Gene Rooting Of Seed Plants And The Phylogenetic Position Of Flowering Plants, Sarah Mathews, Mark D. Clements, Mark A. Beilstein Feb 2010

A Duplicate Gene Rooting Of Seed Plants And The Phylogenetic Position Of Flowering Plants, Sarah Mathews, Mark D. Clements, Mark A. Beilstein

Faculty Publications

Flowering plants represent the most significant branch in the tree of land plants, with respect to the number of extant species, their impact on the shaping of modern ecosystems and their economic importance. However, unlike so many persistent phylogenetic problems that have yielded to insights from DNA sequence data, the mystery surrounding the origin of angiosperms has deepened with the advent and advance of molecular systematics. Strong statistical support for competing hypotheses and recent novel trees from molecular data suggest that the accuracy of current molecular trees requires further testing. Analyses of phytochrome amino acids using a duplicate gene-rooting approach …

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Uncoupling Of Inflammation And Insulin Resistance By Nf-Κb In Transgenic Mice Through Elevated Energy Expenditure, Tianyi Tang, Jin Zhang, Jun Yin, Jaroslaw Staszkiewicz, Barbara Gawronska-Kozak, Dae Young Jung, Hwi Jin Ko, Helena Ong, Jason K. Kim, Randy Mynatt, Roy J. Martin, Michael Keenan, Zhanguo Gao, Jianping Ye Feb 2010

Uncoupling Of Inflammation And Insulin Resistance By Nf-Κb In Transgenic Mice Through Elevated Energy Expenditure, Tianyi Tang, Jin Zhang, Jun Yin, Jaroslaw Staszkiewicz, Barbara Gawronska-Kozak, Dae Young Jung, Hwi Jin Ko, Helena Ong, Jason K. Kim, Randy Mynatt, Roy J. Martin, Michael Keenan, Zhanguo Gao, Jianping Ye

Faculty Publications

To study the metabolic activity of NF-κB, we investigated phenotypes of two different mouse models with elevated NF-κB activities. The transcriptional activity of NF-κB is enhanced either by overexpression of NF-κB p65 (RelA) in aP2-p65 mice or inactivation of NF-κBp50 (NF-κB1) through gene knock-out. In these models, energy expenditure was elevated in day and night time without a change in locomotion. The mice were resistant to adulthood obesity and diet-induced obesity without reduction in food intake. The adipose tissue growth and adipogenesis were inhibited by the elevated NF-κB activity. Peroxisome proliferator-activator receptor γ expression was reduced by NF-κB at the …

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Reversibility Of Β-Amyloid Self-Assembly: Effects Of Ph And Added Salts Assessed By Fluorescence Photobleaching Recovery, Nadia J. Edwin, Robert P. Hammer, Robin L. Mccarley, Paul S. Russo Feb 2010

Reversibility Of Β-Amyloid Self-Assembly: Effects Of Ph And Added Salts Assessed By Fluorescence Photobleaching Recovery, Nadia J. Edwin, Robert P. Hammer, Robin L. Mccarley, Paul S. Russo

Faculty Publications

The 40-residue peptide isoform β-amyloid (Aβ1-40) is associated with Alzheimer's disease. Although found in the tangles and fibrous mats that characterize the brain in advanced stages of the disease, the toxic form of Aβ is believed to be oligomers or "protofibrils". Characterization of these fairly small structures in solution, especially in the presence of the much larger assemblies they also form, is a daunting task. Additionally, little is known about the rate of Aβ assembly or whether it can be triggered easily. Perhaps most importantly, the conditions for reversing assembly are not fully understood. Fluorescence photobleaching with modulation detection of …

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Dynamic Clamp: Alteration Of Response Properties And Creation Of Virtual Realities In Neurophysiology., Economo Mn, Fernandez Fr, White Ja Feb 2010

Dynamic Clamp: Alteration Of Response Properties And Creation Of Virtual Realities In Neurophysiology., Economo Mn, Fernandez Fr, White Ja

Faculty Publications

No abstract provided.

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Six Rna Viruses And Forty-One Hosts: Viral Small Rnas And Modulation Of Small Rna Repertoires In Vertebrate And Invertebrate Systems, Poornima Parameswaran, Ella Sklan, Courtney Wilkins, Trever Burgon, Melanie A. Samuel, Rui Lu, K. Mark Ansel, Vigo Heissmeyer, Shirit Einav, William Jackson, Tammy Doukas, Suman Paranjape, Charlotta Polacek, Flavia Barreto Dos Santos, Roxana Jalili, Farbod Babrzadeh, Baback Gharizadeh, Dirk Grimm, Mark Kay, Satoshi Koike, Peter Sarnow, Mostafa Ronaghi, Shou Wei Ding, Eva Harris, Marie Chow, Michael S. Diamond, Karla Kirkegaard, Jeffrey S. Glenn, Andrew Z. Fire Feb 2010

Six Rna Viruses And Forty-One Hosts: Viral Small Rnas And Modulation Of Small Rna Repertoires In Vertebrate And Invertebrate Systems, Poornima Parameswaran, Ella Sklan, Courtney Wilkins, Trever Burgon, Melanie A. Samuel, Rui Lu, K. Mark Ansel, Vigo Heissmeyer, Shirit Einav, William Jackson, Tammy Doukas, Suman Paranjape, Charlotta Polacek, Flavia Barreto Dos Santos, Roxana Jalili, Farbod Babrzadeh, Baback Gharizadeh, Dirk Grimm, Mark Kay, Satoshi Koike, Peter Sarnow, Mostafa Ronaghi, Shou Wei Ding, Eva Harris, Marie Chow, Michael S. Diamond, Karla Kirkegaard, Jeffrey S. Glenn, Andrew Z. Fire

Faculty Publications

We have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have been shown in plant and invertebrate systems to play a key role in host responses to viral infection. Although homologs of the key RNAi effector pathways are present in mammalian cells, and can launch an RNAi-mediated degradation of experimentally targeted mRNAs, any role for such responses in mammalian host-virus interactions remains to be characterized. Six different viruses were examined in 41 experimentally susceptible and resistant host systems. We identified virus-derived …

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Kaposi's Sarcoma-Associated Herpesvirus Glycoproteins B And K8.1 Regulate Virion Egress And Synthesis Of Vascular Endothelial Growth Factor And Viral Interleukin-6 In Bcbl-1 Cells, R. Subramanian, I. Sehgal, O. D'Auvergne, K. G. Kousoulas Feb 2010

Kaposi's Sarcoma-Associated Herpesvirus Glycoproteins B And K8.1 Regulate Virion Egress And Synthesis Of Vascular Endothelial Growth Factor And Viral Interleukin-6 In Bcbl-1 Cells, R. Subramanian, I. Sehgal, O. D'Auvergne, K. G. Kousoulas

Faculty Publications

Kaposi's sarcoma-associated herpesvirus (KSHV) viral glycoproteins play important roles in the infectious life cycle and have been implicated in KSHV-associated endothelial cell transformation, angiogenesis, and KS-induced malignancies. KSHV-associated primary effusion lymphomas (PELs) secrete high levels of vascular endothelial growth factor (VEGF) and viral interleukin-6 (vIL-6) in vitro and VEGF, vIL-6, and basic-fibroblast growth factor (b-FGF) in mouse xenografts. KSHV-encoded glycoproteins B (gB) and K8.1 stimulate VEGF secretion, most likely mediated by direct or indirect binding to cell surface receptors, including the gB-specific αVβ3 and α3β1 integrins. In this study, the short interfering RNA (siRNA)-mediated inhibition of either gB or K8.1 …

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The Combined Effects Of Rivers And Refugia Generate Extreme Cryptic Fragmentation Within The Common Ground Skink (Scincella Lateralis), Nathan D. Jackson, Christopher C. Austin Feb 2010

The Combined Effects Of Rivers And Refugia Generate Extreme Cryptic Fragmentation Within The Common Ground Skink (Scincella Lateralis), Nathan D. Jackson, Christopher C. Austin

Faculty Publications

Rivers can act as both islands of mesic refugia for terrestrial organisms during times of aridification and barriers to gene flow, though evidence for long-term isolation by rivers is mixed. Understanding the extent to which riverine barrier effects can be heightened for populations trapped in mesic refugia can help explain maintenance and generation of diversity in the face of Pleistocene climate change. Herein, we implement phylogenetic and population genetic approaches to investigate the phylogeographic structure and history of the ground skink, Scincella lateralis, using mtDNA and eight nuclear loci. We then test several predictions of a river-refugia model of diversification. …

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Intracellular Consequences Of Sos1 Deficiency During Salt Stress, Dong Ha Oh, Sang Yeol Lee, Ray A. Bressan, Dae Jin Yun, Hans J. Bohnert Feb 2010

Intracellular Consequences Of Sos1 Deficiency During Salt Stress, Dong Ha Oh, Sang Yeol Lee, Ray A. Bressan, Dae Jin Yun, Hans J. Bohnert

Faculty Publications

A mutation of AtSOS1 (Salt Overly Sensitive 1), a plasma membrane Na +/H+-antiporter in Arabidopsis thaliana, leads to a salt-sensitive phenotype accompanied by the death of root cells under salt stress. Intracellular events and changes in gene expression were compared during a non-lethal salt stress between the wild type and a representative SOS1 mutant, atsos1-1, by confocal microscopy using ion-specific fluorophores and by quantitative RT-PCR. In addition to the higher accumulation of sodium ions, atsos1-1 showed inhibition of endocytosis, abnormalities in vacuolar shape and function, and changes in intracellular pH compared to the wild type in root tip cells under …

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