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Effects Of Row Spacing And Debris Distribution On Small Mammal And Vegetation Communities In Newly Established Loblolly Pine Plantations, Louisiana, Joshua Lee Grace Jan 2011

Effects Of Row Spacing And Debris Distribution On Small Mammal And Vegetation Communities In Newly Established Loblolly Pine Plantations, Louisiana, Joshua Lee Grace

LSU Master's Theses

Commercial pine (Pinus spp.) forests in the southeastern United States are key to providing fiber for global wood supply needs. Concern has arisen over possible effects of intensive forest management techniques, including row spacing and distribution of woody debris after logging, on plant and wildlife communities. Therefore, we quantified response of plant and small mammal communities in replanted loblolly pine (P. taeda) stands to mechanical site preparation including 2 levels of row spacing and 2 methods of distributing woody debris following harvest in north and southeastern Louisiana, USA. Sites (n=16) were prepared with a combination of row spacing between planting …

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Animal Scavengers As Agents Of Decomposition: The Postmortem Succession Of Louisiana Wildlife, Audra Leigh Jones Jan 2011

Animal Scavengers As Agents Of Decomposition: The Postmortem Succession Of Louisiana Wildlife, Audra Leigh Jones

LSU Master's Theses

Four adult pig carcasses were placed within a wildlife center in Baton Rouge, Louisiana, in order to determine what conditions animals utilize carrion and which animal species engage in scavenging. The cadavers were deposited without any protective covering and wildlife cameras were placed around the pigs in order to document animal scavenging. In two cases cameras showed that coyotes were the initial animal scavengers followed by opossums. In another case coyotes were inferred to have scavenged the pig due to discovering a similar pattern of disarticulation as compared to the previous two scenes. In the third case turkey vultures skeletonized …

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Trials & Tributaries: Myth And Disaster In Southern Louisiana, Hannah March Campbell Sanders Jan 2011

Trials & Tributaries: Myth And Disaster In Southern Louisiana, Hannah March Campbell Sanders

LSU Master's Theses

Trials and Tributaries examines recent disasters occurring in southern Louisiana, interpreted through the Greek myths The Twelve Labors of Herakles. Mankind’s false sense of control over Louisiana’s resources leaves us vulnerable to nature’s powerful acts of reclamation: hurricanes, floods and the ground sinking beneath our feet. While researching the details and origins of The Twelve Labors, I found a plethora of similarities with local culture, politics and natural disasters. The characters in these narrative prints include hybrid monsters drawn from Greek mythology, which I have then further augmented with various forms of local south Louisiana fauna and contemporary political figures. …

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Geomicrobiology Of Louisiana Coastal Marshes Before And After The Deepwater Horizon Oil Spill, Chang Liu Jan 2011

Geomicrobiology Of Louisiana Coastal Marshes Before And After The Deepwater Horizon Oil Spill, Chang Liu

LSU Master's Theses

The 2010 Deepwater Horizon oil spill in the Gulf of Mexico not only impacted open ocean and shoreline geochemical and ecological environments, but it served to promote research of microbial ecosystems in poorly studied habitats, such as Louisiana marshes. Sediment and water samples from four main marshes in southern Louisiana were collected in May 2010 (pre-oil), September 2010 (oiled), and June 2011 (post-oil). Sites near the Mississippi River had exceptionally low salinity in the immediate months following the oil spill due to freshwater diversion efforts; salinity increased by an order of magnitude one year later. Microbial diversity was evaluated from …

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Advanced Management Of The Mexican Rice Borer (Eoreuma Loftini) In Sugarcane, Blake Emerson Wilson Jan 2011

Advanced Management Of The Mexican Rice Borer (Eoreuma Loftini) In Sugarcane, Blake Emerson Wilson

LSU Master's Theses

Insecticide, greenhouse and varietal resistance experiments were conducted in Texas to develop management tactics for the Mexican rice borer, Eoreuma loftini (Dyar), sugarcane. A 3-treatment, large plot aerial application study was set up in 5 commercial sugarcane fields (35-84 acres) to evaluate the utilization of pheromone traps to improve chemical control strategies for E. loftini during 2009 and 2010 growing seasons. A threshold of 20-25 moths/trap/wk was used as an indicator to initiate monitoring for E. loftini larval infestations. Larval infestations were directly related to the no. of moths/trap/wk (R2=0.71). Reductions in borer injury and adult emergence (60% and 40% …

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Demography, Paleopathology, And Health Status Of The Moche Remains In Huambacho, Peru: A Comprehensive Osteological Analysis, Emily Grace Jan 2011

Demography, Paleopathology, And Health Status Of The Moche Remains In Huambacho, Peru: A Comprehensive Osteological Analysis, Emily Grace

LSU Master's Theses

The Moche civilization, which thrived in northern Peru from AD 100-800, influenced a vast area that extended to the southernmost monumental site of Pañamarca. Huambacho, an archaeological site in the Nepeña Valley, which dates to the Early Horizon (600-200 cal BC), has yielded multiple Moche graves uncovered by the Proyecto Huambacho (2003-2004). The graves provide the first evidence of Moche presence outside of the neighboring Pañamarca monumental complex. This research entailed the osteological analysis of eleven individuals from nine Moche grave contexts at Huambacho, including the analysis of demographic features, pathology, trauma, and antemortem cultural modifications. Methodology included the visual …

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Mechanical Evaluation Of Aluminum Oxide Roughened Screws In Equine Third Metacarpal Bone, Petrisor Baia Jan 2011

Mechanical Evaluation Of Aluminum Oxide Roughened Screws In Equine Third Metacarpal Bone, Petrisor Baia

LSU Master's Theses

ABSTRACT Objectives – To compare the osseointegration of roughened and electropolished 5.5 mm cortical screws used to secure a 4.5 mm broad dynamic compression plate (DCP) in equine third metacarpal (MC3) bones. Study Design – In vivo study Animals – 5 Adult thoroughbred horses (2-7 years old). Methods – For each horse one MC3 was randomly assigned to secure a 4.5 mm broad DCP with 4aluminum oxide (Al2O3) roughened screws on the dorsal mid diaphysis. Four regular electropolished screws used to secure a similar plate on the contralateral limb served as control. They were removed at 12 weeks and the …

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Marriage In Seventeenth-Century French Theater, Adam Michael Babin Jan 2011

Marriage In Seventeenth-Century French Theater, Adam Michael Babin

LSU Master's Theses

In seventeenth-century France, social and political confusion abounded. Absolute monarchy, which was principally created by Richelieu and glorified by Louis XIV, began gradually replacing the medieval feudalism that remained popular among the nobles. Likewise, préciosité, a proto-feminist literary and cultural movement that was not in line with official political ideals, emerged in France during this century. The institution of marriage was an important element of the complicated sociopolitical tapestry of seventeenth-century France. Through the depiction of marriage in Pierre Corneille’s Le Cid (1636), Jean-Baptiste Poquelin de Molière’s L’École des femmes (1662), and Jean Racine’s Andromaque (1667), three works of the …

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Inhibitory Effects Of Berry Anthocyanins On Palmitic Acid- Or Lipopolysaccharide- Induced Inflammation In Human Preadipocytes, Chenfei Gao Jan 2011

Inhibitory Effects Of Berry Anthocyanins On Palmitic Acid- Or Lipopolysaccharide- Induced Inflammation In Human Preadipocytes, Chenfei Gao

LSU Master's Theses

Obesity is an inflammatory disease associated with the development and progression of chronic degenerative diseases including insulin resistance, cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and cancer. Circulating free fatty acid (FFA) are known risk factors promoting inflammation that can lead to CVD. Pre/adipocytes are known storage of low grade inflammatory biomarkers associated with obesity. However, the effects of dietary anthocyanins on inflammatory biomarkers in preadipocytes have not been reported. Berries are rich sources of naturally occurring antioxidant polyphenolics. There is increasing interest in the ability of berry anthocyanins to provide health benefits against obesity. Anthocyanins were isolated from …

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Evaluation Of Selected Plant Products As Dietary Protein Sources For Florida Pompano (Trachinotus Carolinus), Gregory Lech Jan 2011

Evaluation Of Selected Plant Products As Dietary Protein Sources For Florida Pompano (Trachinotus Carolinus), Gregory Lech

LSU Master's Theses

Profitability of aquaculture enterprises worldwide has been affected by rising fish meal prices. Plant proteins are promising replacements for fish meal because of their lower cost and worldwide availability. The goal of this research was to provide nutritional information for the development of all-plant diets for Florida pompano by evaluating growth of fish fed soy-based, fish-meal-free diets and assessing the nutritional value of several plant protein sources. In the first experiment, juvenile Florida pompano were fed five, soy-based, fish-meal-free diets containing graded levels of soybean meal (SBM, or M) at 0, 20, 25, 30, or 35%, with the remaining protein …

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Antarctic Plant And Phytoplankton Response To The First Phase Of The Mid Miocene Climatic Optimum At South Mcmurdo Sound, Lee Foersterling Jan 2011

Antarctic Plant And Phytoplankton Response To The First Phase Of The Mid Miocene Climatic Optimum At South Mcmurdo Sound, Lee Foersterling

LSU Master's Theses

The Antarctic Drilling Program (ANDRILL) recovered 1138.54 m of sub-seafloor marine sediments with 98% core recovery at the AND2-2A drill site in South McMurdo Sound. Biostratigraphy, magnetostratigraphy, and isotopic dating (Acton et al., 2008) indicated that an Early to Middle Miocene section (223-1138.54 mbsf) was recovered. This study focuses on an interval with high concentrations of palynomorphs, located between 460.57 and 403.48 mbsf and dated to 16.7 Ma to 16.2 Ma according to the updated Acton et al. (2008) ANDRILL SMS age model. Palynological results show a pronounced increase in organic microfossils between 434.01 and 431.91 mbsf, compared to levels …

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Neutralizing Gender: Autonomy's Role In Disarming Gender Bias, Scott Szymanski Jan 2011

Neutralizing Gender: Autonomy's Role In Disarming Gender Bias, Scott Szymanski

LSU Master's Theses

Figuring out what one’s identity means has always been an essential task of human life. Decidedly, our values, commitments, aspirations, and experiences all contribute to this identity. I submit that individuals have control over who they are and what they become by way of these attributes. As such, control over these characteristics gives us the power to define ourselves as we wish. In my thesis, I attempt to express how autonomy is imperative for this control. I take issue with traditional notions of autonomy, concluding that they do not take into account all that is necessary to ensure a person …

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The Reproductive Morphology And Physiological Age-Grading Of Female Cyrtobagous Salviniae, The Salvinia Weevil, Lee Jared Eisenberg Jan 2011

The Reproductive Morphology And Physiological Age-Grading Of Female Cyrtobagous Salviniae, The Salvinia Weevil, Lee Jared Eisenberg

LSU Master's Theses

Over 1000 dissections were performed on field, greenhouse and lab specimens in order to describe the reproductive system of Cyrtobagous salviniae, a biocontrol agent of Salvinia molesta (giant salvinia). The reproductive morphology of C. salviniae was described, the classes of reproductive development were characterized, and oviposition assessed. The reproductive system of C. salviniae consists of two ovaries, each of which is comprised of two membraneous ovarioles. These are each divided into a distal germarium and a proximal vitellarium that is connected to a lateral oviduct. The lateral oviducts unite to form a common oviduct through which eggs must pass for …

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Hurricane Induced Land And Vegetation Changes In The Breton Sound Estuary And Chandeleur Islands Using Landsat 5 Tm, Vandana Varshini Raghunathan Jan 2011

Hurricane Induced Land And Vegetation Changes In The Breton Sound Estuary And Chandeleur Islands Using Landsat 5 Tm, Vandana Varshini Raghunathan

LSU Master's Theses

This study focuses on hurricane-induced changes in land and vegetation primarily in two study areas, the Breton Sound Estuary and the Chandeleur Islands, southeast of New Orleans, Louisiana. Breton Sound Estuary consists of the Caernarvon Diversion, a fresh water diversion of the Mississippi River that supplies this region with managed pulses of fresh water and sediments. The Chandeleur Islands are a chain of barrier islands that are uninhabited and transgressive in nature. A sequence of hurricanes in the past two decades has greatly altered both areas significantly. Satellite data were analyzed for a period of 24 years (1987-2011) of Breton …

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Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba Jan 2011

Transport Properties Of Nanometer-Sized Assemblies Through Nanofluidic Channels With Single Entity Electrical Detection, Franklin Ifeanyichukwu Uba

LSU Master's Theses

Recently, there have been reports on biological and solid-state nanopores that identify single biopolymers or their constituent monomers by analyzing changes in ionic current blockades when they block the flux of buffer ions while travelling through the nanopores. Nevertheless, there have been several limitations in their application, especially as DNA detectors; Poor confinement of the DNA strand within the nanopore (~0.1 % of a 10 kilobase (kb) DNA), poor signal sensitivity and random motion experienced by the DNA in solution that results in a large amount of noise in the signal. These have led to the development of nanochannel-based devices, …

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Work In Process: Inhabiting Matter In Time, James Joseph Legeai Jan 2011

Work In Process: Inhabiting Matter In Time, James Joseph Legeai

LSU Master's Theses

The typical American house is conceived of and constructed as a permanent and singular object. This method of permanent design and construction is not conducive to sustainable resource and material protection. The permanent connections and material customizations used in construction disallow most C&D (construction and demolition) materials from being salvaged, reused or recycled once the house has reached its end-of-life. As a result, residential demolition in America produces for over 19 million tons of material waste each year (US EPA 6). Deconstruction offers a valid alternative to demolition but is not commonly practiced for two main reasons. First, deconstruction remains …

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Carbon Sequestration And Uneven-Aged Management Of Loblolly Pine Stands In The Southern Usa: A Joint Optimization Approach, Rajan Parajuli Jan 2011

Carbon Sequestration And Uneven-Aged Management Of Loblolly Pine Stands In The Southern Usa: A Joint Optimization Approach, Rajan Parajuli

LSU Master's Theses

Forest carbon sequestration is regarded as a viable and cost effective option for reducing global greenhouse gas emissions. Several research studies analyzed the effects of joint management of carbon and timber under different even-aged forest management scenarios, and concluded that carbon benefits can alter forest management schedules significantly. However, research specifically focused on the inclusion of carbon sequestration benefits into uneven-aged management has received little attention. This study determined the optimum joint management regime of timber and carbon in uneven-aged loblolly pine stands in Louisiana, and assessed management and financial effects resulting from the integration of carbon benefits into uneven-aged …

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Characterization Of The Subcortical Interactions Between Larvae Of The Southern Pine Sawyer Monochamus Titillator (F.) And The Larvae Of The Southern Pine Beetle Guild Using Molecular Gut Analyses, Erich N. Schoeller Jan 2011

Characterization Of The Subcortical Interactions Between Larvae Of The Southern Pine Sawyer Monochamus Titillator (F.) And The Larvae Of The Southern Pine Beetle Guild Using Molecular Gut Analyses, Erich N. Schoeller

LSU Master's Theses

The southern pine beetle guild (Coleoptera: Curculionidae: Scolytinae) is arguably the most destructive group of forest pests in the Southeastern United States. Laboratory assays suggest that larvae of wood borer associates from the genus Monochamus (Coleoptera: Cerambycidae) may be facultative intraguild predators of southern pine beetle guild. In this study the dynamics of the subcortical interactions between M. titillator (F.) and members of the southern pine beetle guild were examined using PCR-based molecular gut content analyses. Species-specific PCR primer sets were developed to work under multiplex PCR conditions to detect DNA of members of southern pine beetle guild in the …

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A Look At The Integration Of Wetlands And Hazard Mitigation Planning In Coastal Louisiana, Kathleen Melissa Bowers Jan 2011

A Look At The Integration Of Wetlands And Hazard Mitigation Planning In Coastal Louisiana, Kathleen Melissa Bowers

LSU Master's Theses

Due to the destruction of the damaging hurricanes of 2005, Katrina and Rita, more effort has gone into the rebuilding and prevention of future disasters along the Louisiana coast than ever before. This research focuses on the use of wetlands, in the ten coastal parishes of Louisiana, as a mitigation effort aiding in the protection of coastal communities. Using content analysis and decision support software, a wetland ranking was created that represents how wetlands are utilized and protected within each parish. Criteria gathered from the plans include how many times wetlands were mentioned, collaboration with the state and other agencies, …

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Are Local Chemical Releases Causing An Increase In Cancer Rates In East Baton Rouge Parish?, India T. Anderson Jan 2011

Are Local Chemical Releases Causing An Increase In Cancer Rates In East Baton Rouge Parish?, India T. Anderson

LSU Master's Theses

Environmental pollution has become a steadily growing problem in today’s society. East Baton Rouge alone has 13 chemical plants in the parish. The goal of this research is to find out if the chemical releases in the parish are having an effect on the cancer rates in East Baton Rouge Parish. I gathered data from all 64 parishes in Louisiana. The four chemicals I chose to study specifically, Benzene, Dioxin, Formaldehyde, and Xylene. Chemical release data was taken from the Toxic Release Inventory (TRI) website and software from the years1988 to 2009, which was the last reporting year. The cancers …

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Stochastic Modelling Of Eukaryotic Cell Cycle, Murali Krushna Koneru Jan 2011

Stochastic Modelling Of Eukaryotic Cell Cycle, Murali Krushna Koneru

LSU Master's Theses

Stochastic models are developed to capture the inherent stochasticity of the biochemical networks associated to many biological processes. The objective of the present thesis is to present a detailed picture of stochastic approach for the mathematical modeling of eukaryotic cell cycle, to demonstrate an important application of such model in chemotherapy and to present a methodology for selecting the model parameters. The stochastic cell cycle model, developed using stochastic chemical kinetics approach, leads to the formation of an infinite dimensional differential equation in probabilities of system being in a specific state. Using Monte Carlo simulations of this model, dynamics of …

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The Design And Modification Of A Sputter System For Dc Reactive Sputtering Of Alumina And Zirconia Thin Films, Diane Van Ho Jan 2011

The Design And Modification Of A Sputter System For Dc Reactive Sputtering Of Alumina And Zirconia Thin Films, Diane Van Ho

LSU Master's Theses

Yttria-stabilized zirconia (7% YSZ) is the most used material for thermal barrier coatings (TBCs) to reduce the conductive heat transfer on turbine blades, but it is not resistant to infrared radiation. In order to reduce radiation heat transfer, alternating materials, such as alumina and zirconia, can be used to fabricate multi-layer coatings in which each layer is optimized to reflect a targeted range of wavelength. This research aims to fabricate these multi-layer coatings by reactive magnetron sputtering. Reactive magnetron sputtering is the sputtering of an elemental target in the presence of a reactive gas that will react with the target …

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Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden Jan 2011

Selection And Enumeration Of Low Epcam Expressing Breast Cancer Ctcs Using A High Throughput Microfluidic Device, Brandy Charon Snowden

LSU Master's Theses

Breast cancer cells overexpress EpCAM that can be used as a marker to select breast cancer CTCs from heterogeneous clinical samples, even when present in low abundance. This study used MDA-MB-231 cells which have a low expression level of EpCAM (1.7 x 103 binding sites per cell.3) Herein, we will report on the use of antiEpCAM antibodies immobilized onto the surface of a capture bed poised within a PMMA microchip that was fabricated into an HTMSU used for selection of breast cancer CTCs seeded into a buffer solution. The microchannel walls within the capture bed were UV modified for 5, …

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Screening Of Tar Cracking Catalysts For Syngas Produced By Biomass Gasification, Bijeet Mukherjee Jan 2011

Screening Of Tar Cracking Catalysts For Syngas Produced By Biomass Gasification, Bijeet Mukherjee

LSU Master's Theses

The gasification of biomass produces tars and particulates. These tars and particulates create problems in the gasification systems. Tars condense on surfaces at lower temperatures, such as exit pipes and on particulate filters, leading to blockages and clogged filters. Tars also have varied impacts on other downstream processes. Due to these reasons, syngas containing significant concentrations of tars cannot be used in internal combustion engines. Thus the processes through which tars can be removed have been subject to considerable research. The objective of this research was to identify the best catalyst for for down-draft gasifiers, including the LSU AgCenter down-draft …

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The Transient Wave Effect And Real Losses Correlation-Frequency, Temporal, And Spatial Analysis, Dina Sa Knight Jan 2011

The Transient Wave Effect And Real Losses Correlation-Frequency, Temporal, And Spatial Analysis, Dina Sa Knight

LSU Master's Theses

Water distribution systems are prone to transients since pumps need to be started and stopped, pumps may have sudden flow changes, human blunders can occur, equipment may fail, or other unavoidable natural events may ensue. Surge modeling techniques are available to calculate variations in pressure, under extreme or normal operating conditions, serving as a tool to predict extreme events in order to design a suitable system and, or, to aid in the implementation of proper measures to mitigate transients. However, modeling an entire water network system may not be cost effective and may require extensive research and time especially in …

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Inhibitory Activity Of Ginger Oil Against Breast Cancer Cells, Namrata Karki Jan 2011

Inhibitory Activity Of Ginger Oil Against Breast Cancer Cells, Namrata Karki

LSU Master's Theses

Breast cancer is the leading cause of cancer related mortality in women. The estimated new cases and death for 2010 in the US for females were 207,090 and 39,840 and for men were 1,970 and 390 respectively. Breast cancer cells contain cancer stem cells (CSCs), which represent less than 5% of the total cancer cell population, but accounts for continuous proliferation and growth. Breast cancer is highly metastatic and can spread to various parts of the body. Signaling through cell surface markers, including CD44/CD24/ALDH1 in breast cancer, pro-survival factors, including Hsp90 and other client proteins, angiogenic biomarkers and telomerase activity …

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Production Of Spray-Dried Honey Powder And Its Application In Bread, Ahalya Kosal Ram Jan 2011

Production Of Spray-Dried Honey Powder And Its Application In Bread, Ahalya Kosal Ram

LSU Master's Theses

Honey is a natural sweetener with various beneficial properties including anti-oxidant and anti-microbial activity. Retrograded starch is known to have hypocholesterolemic effects and act to inhibit fat accumulation. Honey powder produced using retrograded starch can be used as an alternative to sucrose in many bakery products like bread. The objectives of this study were to produce a honey powder containing retrograded starch, characterize the powder and use it as an alternative to sucrose in bread formulations. The honey powder was produced by spray drying honey using retrograded starch as a drying agent. The spray dried honey powder was characterized for …

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Surface-Enhanced Raman Spectroscopy Substrates Based On Nanoporous Silicon And Pattern Transfer, Pallavi Rao Malempati Jan 2011

Surface-Enhanced Raman Spectroscopy Substrates Based On Nanoporous Silicon And Pattern Transfer, Pallavi Rao Malempati

LSU Master's Theses

Surface-enhanced Raman scattering enhances the weak Raman scattering by using a roughened metal-coated surface as a catalyst. Roughness in the nanometer range provides the best enhancement. The nanostructures for the surface-enhanced Raman spectroscopy (SERS) substrates, in this work, are generated using an electrochemical etching process on silicon substrates. The patterns of nanoporous silicon thus generated are transferred onto transparent polydimethylsiloxane (PDMS) substrates using the “lift-off” process. An incomplex sputtering technique is employed to coat this substrate with a ~20 nm aluminum layer. Rhodamine 6G (R6G) molecules, when adsorbed to this metal surface, form the final SERS substrate that undergoes Raman …

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Manganese (Ii) And Protein Oxidation As Determinants Of Bacterial Ionizing Radiation Resistance, Jana Ronnette Robins Jan 2011

Manganese (Ii) And Protein Oxidation As Determinants Of Bacterial Ionizing Radiation Resistance, Jana Ronnette Robins

LSU Master's Theses

The mechanisms that contribute to bacterial ionizing radiation resistance are not completely understood. The Daly model uses Deinococcus radiodurans to suggest that bacterial ionizing radiation resistance is primarily determined by the amount of protein oxidation produced in response to ionizing radiation, so protein oxidation will be limited in radioresistant microorganisms due to a high intracellular level of manganese (Mn). This thesis investigates the Daly model by first introducing oxidative damage to Beta-Galactosdiase using increasing doses of gamma irradiation. Beta-Galactosidase activity was measured by the production of o-nitrophenol (ONP) which is produced from the hydrolysis of o-nitrophenyl-Beta-D-galactoside (ONPG). Beta-Galactosidase activity decreased …

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Efficient Replica-Exchange Across Distributed Production Infrastructure, Abhinav S. Thota Jan 2011

Efficient Replica-Exchange Across Distributed Production Infrastructure, Abhinav S. Thota

LSU Master's Theses

Replica-Exchange (RE) methods represent a class of algorithms that involve a large number of loosely-coupled ensembles and are used to understand physical phenomena -- ranging from protein folding dynamics to binding affinity calculations. We develop a framework for RE that supports different replica pairing and coordination mechanisms, that can use a wide range of production cyberinfrastructure concurrently. Additionally, our framework uses a flexible pilot-job implementation, which enables effective resource allocation for multiple replicas. We characterize the performance of two different RE algorithms - synchronous and asynchronous - at unprecedented scales on production distributed infrastructure (Teragrid and LONI). The synchronous RE …

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