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A Perspective On The Transition To Plant-Based Diets: A Diet Change May Attenuate Climate Change, But Can It Also Attenuate Obesity And Chronic Disease Risk, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup Jan 2020

A Perspective On The Transition To Plant-Based Diets: A Diet Change May Attenuate Climate Change, But Can It Also Attenuate Obesity And Chronic Disease Risk, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup

Clinical Research Faculty Publications

Current dietary guidelines advocate more plant-based, sustainable diets on the basis of scientific evidence about diet-health relations but also to address environmental concerns. Here, we critically review the effects of plant-based diets on the prevalence of obesity and other health outcomes. Plant-based diets per se have limited efficacy for the prevention and treatment of obesity, but most have beneficial effects in terms of chronic disease risk. However, with the considerable possibilities of translating plant-based diets into various types of dietary patterns, our analysis suggests that potential adverse health effects should also be considered in relation to vulnerable groups of the …

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The Environmental Foodprint Of Obesity, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup Jan 2020

The Environmental Foodprint Of Obesity, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup

Clinical Research Faculty Publications

Emissions of greenhouse gases (GHG) are linked to global warming and adverse climate changes. Meeting the needs of the increasing number of people on the planet presents a challenge for reducing total GHG burden. A further challenge may be the size of the average person on the planet and the increasing number of people with excess body weight. We used data on GHG emissions from various sources and estimated that obesity is associated with ~20% greater GHG emissions compared with the normal-weight state. On a global scale, obesity contributes to an extra GHG emissions of ~49 megatons per year of …

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The Love Of Aerial Practice: Art, Embodiment, Phronesis, Maria Kosma, Nick Erickson Jan 2020

The Love Of Aerial Practice: Art, Embodiment, Phronesis, Maria Kosma, Nick Erickson

Faculty Publications

Background of study: Given the importance of movement and low exercise adherence among young adults, it is imperative to understand reasons for the love of movement. Objective: The purpose of this phronetic, qualitative study was to examine if the values of aerial practice encompassed elements of embodiment, techne (art), and phronesis (practical wisdom). Method: Participants were 13 undergraduate college students in an aerial practice class. Individual-based interview topics included exercise behavior and the values and meaning of aerial practice. Results: All participants were active regardless of aerial practice classification (e.g., beginners vs advanced). Beyond aerial practice, other exercises included dancing, …

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Prenatal Gestational Diabetes Mellitus Exposure And Accelerated Offspring Dna Methylation Age In Early Childhood, Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli Jan 2020

Prenatal Gestational Diabetes Mellitus Exposure And Accelerated Offspring Dna Methylation Age In Early Childhood, Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli

Population and Public Health Science Faculty Publications

Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3-10 years of age in the Tianjin GDM Observational Study. Methods: This study included 578 GDM and 578 non-GDM mother-child pairs. Children underwent a physical exam that included anthropometric measurements and a blood draw for DNAm analysis (Illumina 850K array) at a median age of 5.9 years (range 3.1-10.2). DNAm age was calculated using two epigenetic clock algorithms (Horvath and Hannum). The residual resulting from regressing DNAm age on chronological age was used as a metric for age acceleration. Results: Chronological age was positively …

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Plasma Metabolomic Profile In Chronic Thromboembolic Pulmonary Hypertension, Gustavo A. Heresi, Jacob T. Mey, John R. Bartholomew, Ihab S. Haddadin, Adriano R. Tonelli, Raed A. Dweik, John P. Kirwan, Satish C. Kalhan Jan 2020

Plasma Metabolomic Profile In Chronic Thromboembolic Pulmonary Hypertension, Gustavo A. Heresi, Jacob T. Mey, John R. Bartholomew, Ihab S. Haddadin, Adriano R. Tonelli, Raed A. Dweik, John P. Kirwan, Satish C. Kalhan

Division of Basic Science Faculty Publications

We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach. We collected fasting plasma from a peripheral vein in 33 operable chronic thromboembolic pulmonary hypertension patients, 31 healthy controls, and 21 idiopathic pulmonary arterial hypertension patients matched for age, gender, and body mass index. Metabolomic analysis was performed using an untargeted approach (Metabolon Inc. Durham, NC). Of the total of 862 metabolites identified, 362 were different in chronic thromboembolic pulmonary hypertension compared to controls: 178 were higher and 184 were lower. Compared to idiopathic pulmonary arterial hypertension, 147 metabolites were different …

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Boxed In: Beliefs About The Compatibility And Likability Of Mother-Occupation And Father-Occupation Role Combinations, Mary C. Noonan, Freda B. Lynn, Mark H. Walker Jan 2020

Boxed In: Beliefs About The Compatibility And Likability Of Mother-Occupation And Father-Occupation Role Combinations, Mary C. Noonan, Freda B. Lynn, Mark H. Walker

Faculty Publications

Researchers have long noted that role expectations of a “good” mother conflict with those of a “good” worker, described as the “cultural contradiction” of motherhood. But given that work roles vary tremendously in terms of the cultural meanings the public assigns them, the authors examine variability in the perceived compatibility of mother-occupation and father-occupation combinations. Building on previous research, the authors hypothesize that (1) some parent-occupation pairings will be viewed as significantly less compatible because of incongruent expectations and meanings, and (2) incumbents of supposedly compatible parent-occupation pairings will be evaluated more favorably than incumbents of incompatible pairings. Both hypotheses …

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Gender Contexts, Dowry And Women's Health In India: A National Multilevel Longitudinal Analysis, Samuel Stroope, Rhiannon A. Kroeger, Jiabin Fan Jan 2020

Gender Contexts, Dowry And Women's Health In India: A National Multilevel Longitudinal Analysis, Samuel Stroope, Rhiannon A. Kroeger, Jiabin Fan

Faculty Publications

Gender-biased contexts may impact women's lives across a variety of domains. This study examined whether changes in district prevalence of a salient gendered practice - dowry - are associated with changes in poor health for women in India. Two waves of national multilevel panel data were used to assess the relationship between changes in district-level dowry prevalence and changes in self-rated health for 23,785 ever-married women aged 15-50 years. Increased dowry prevalence was found to be associated with increased poor self-rated health for women. This relationship remained when controlling for potentially confounding factors including household socioeconomic status, caste, infrastructure, mobility …

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Consumer Perception Of Extruded Snacks Containing Brown Rice And Dried Mushroom, Benjarat Tepsongkroh, Kamolwan Jangchud, Anuvat Jangchud, Pitchayapat Chonpracha, Ryan Ardoin, Witoon Prinyawiwatkul Jan 2020

Consumer Perception Of Extruded Snacks Containing Brown Rice And Dried Mushroom, Benjarat Tepsongkroh, Kamolwan Jangchud, Anuvat Jangchud, Pitchayapat Chonpracha, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

Effects of mushroom type, seasoning and health benefit information (HBI) on consumers’ saltiness expectation, sensory liking, elicited emotions and purchase intent (PI) of extruded snacks were investigated. Five snacks were evaluated: straw mushroom (Volvariella volvacea) extrudates without (SME) or with seasoning (SMES), phoenix mushroom (Pleurotus pulmonarius) extrudates without (PME) or with seasoning (PMES), and the control without mushroom and seasoning. Hedonic scores and positive emotions were generally higher for seasoned mushroom-containing snacks (SMES and PMES) with 65% and 75.83% of consumers reporting willingness to purchase, respectively, after receiving HBI. Bored, interested and satisfied were identified as significant emotional predictors for …

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Genetic Mapping Identifies Consistent Quantitative Trait Loci For Yield Traits Of Rice Under Greenhouse Drought Conditions, Niranjan Baisakh, Jonalyn Yabes, Andres Gutierrez, Venkata Mangu, Peiyong Ma, Adam Famoso, Andy Pereira Jan 2020

Genetic Mapping Identifies Consistent Quantitative Trait Loci For Yield Traits Of Rice Under Greenhouse Drought Conditions, Niranjan Baisakh, Jonalyn Yabes, Andres Gutierrez, Venkata Mangu, Peiyong Ma, Adam Famoso, Andy Pereira

Faculty Publications

Improving drought resistance in crops is imperative under the prevailing erratic rainfall patterns. Drought affects the growth and yield of most modern rice varieties. Recent breeding efforts aim to incorporate drought resistance traits in rice varieties that can be suitable under alternative irrigation schemes, such as in a (semi)aerobic system, as row (furrow-irrigated) rice. The identification of quantitative trait loci (QTLs) controlling grain yield, the most important trait with high selection efficiency, can lead to the identification of markers to facilitate marker-assisted breeding of drought-resistant rice. Here, we report grain yield QTLs under greenhouse drought using an F2:3 population derived …

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Optimization Of Uas-Based High-Throughput Phenotyping To Estimate Plant Health And Grain Yield In Sorghum, Giovanni Galli, David W. Horne, S. Delroy Collins, Jinha Jung, Anjin Chang, Roberto Fritsche-Neto, William L. Rooney Jan 2020

Optimization Of Uas-Based High-Throughput Phenotyping To Estimate Plant Health And Grain Yield In Sorghum, Giovanni Galli, David W. Horne, S. Delroy Collins, Jinha Jung, Anjin Chang, Roberto Fritsche-Neto, William L. Rooney

Faculty Publications

High-throughput phenotyping (HTP) has enabled the acquisition of vast amounts of data. Therefore, finding the most informative phenological stage(s) and high-throughput traits could lead to significant optimization of HTP-assisted selection. An investigation as to when phenotypic data should be collected and how it should be processed from unmanned aerial system (UAS) imagery for the optimization and assessment of two primary traits in grain sorghum [Sorghum bicolor (L). Moench], namely, grain yield and plant health (based on anthracnose scores) was conducted. By evaluating multiple flight dates across the growing season via multispectral UAS-based imagery, a set of scenarios composed of combinations …

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Asian Summer Monsoon Influence On Chemical Weathering And Sediment Provenance Determined By Clay Mineral Analysis From The Indus Submarine Canyon, Yuting Li, Peter D. Clift, Richard W. Murray, Elise Exnicios, Thomas Ireland, Philipp Böning Jan 2020

Asian Summer Monsoon Influence On Chemical Weathering And Sediment Provenance Determined By Clay Mineral Analysis From The Indus Submarine Canyon, Yuting Li, Peter D. Clift, Richard W. Murray, Elise Exnicios, Thomas Ireland, Philipp Böning

Faculty Publications

© Copyright University of Washington. Published by Cambridge University Press, 2019. Clay minerals from the Indus Canyon and eastern clinoform since ∼12 ka are uniformly rich in smectite and illite, similar to those from the Holocene Indus flood plains. A systematic enrichment of smectite in the proximal delta compared to the canyon and eastern clinoform argues for preferential capture of smectite close to the river mouth since ∼12 ka. There is a rapid shift to a more smectite-rich assemblage in the canyon and eastern clinoform after ∼5 ka. This change is probably caused by a change in sediment source, with …

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Sympathetic Innervation Of Inguinal White Adipose Tissue In The Mouse, Clara Huesing, Emily Qualls-Creekmore, Nathan Lee, Marie François, Hayden Torres, Rui Zhang, David H. Burk, Sangho Yu, Christopher D. Morrison, Hans Rudolf Berthoud, Winfried Neuhuber, Heike Münzberg Jan 2020

Sympathetic Innervation Of Inguinal White Adipose Tissue In The Mouse, Clara Huesing, Emily Qualls-Creekmore, Nathan Lee, Marie François, Hayden Torres, Rui Zhang, David H. Burk, Sangho Yu, Christopher D. Morrison, Hans Rudolf Berthoud, Winfried Neuhuber, Heike Münzberg

Faculty Publications

© 2020 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC. Adipose tissue plays an important role in metabolic homeostasis and its prominent role as endocrine organ is now well recognized. Adipose tissue is controlled via the sympathetic nervous system (SNS). New viral, molecular-genetic tools will soon allow a more detailed study of adipose tissue innervation in metabolic function, yet, the precise anatomical extent of preganglionic and postganglionic inputs to the inguinal white adipose tissue (iWAT) is limited. Furthermore, several viral, molecular-genetic tools will require the use of cre/loxP mouse models, while the available studies on sympathetic …

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Role Of Geometric Shape In Chiral Optics, Philipp Gutsche, Xavier Garcia-Santiago, Philipp Immanuel Schneider, Kevin M. Mcpeak, Manuel Nieto-Vesperinas, Sven Burger Jan 2020

Role Of Geometric Shape In Chiral Optics, Philipp Gutsche, Xavier Garcia-Santiago, Philipp Immanuel Schneider, Kevin M. Mcpeak, Manuel Nieto-Vesperinas, Sven Burger

Faculty Publications

The distinction of chiral and mirror symmetric objects is straightforward from a geometrical point of view. Since the biological as well as the optical activity of molecules strongly depend on their handedness, chirality has recently attracted high interest in the field of nano-optics. Various aspects of associated phenomena including the influences of internal and external degrees of freedom on the optical response have been discussed. Here, we propose a constructive method to evaluate the possibility of observing any chiral response from an optical scatterer. Based on solely the T-matrix of one enantiomer, planes of minimal chiral response are located and …

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Characterization Of An Extensive Interface On Vitronectin For Binding To Plasminogen Activator Inhibitor-1: Adoption Of Structure In An Intrinsically Disordered Region, Letitia O. Puster, Christopher B. Stanley, Vladimir N. Uversky, Joseph E. Curtis, Susan Krueger, Yuzhuo Chu, Cynthia B. Peterson Dec 2019

Characterization Of An Extensive Interface On Vitronectin For Binding To Plasminogen Activator Inhibitor-1: Adoption Of Structure In An Intrinsically Disordered Region, Letitia O. Puster, Christopher B. Stanley, Vladimir N. Uversky, Joseph E. Curtis, Susan Krueger, Yuzhuo Chu, Cynthia B. Peterson

Faculty Publications

Copyright © 2019 American Chemical Society. Small-angle neutron scattering (SANS) measurements were pursued to study human vitronectin, a protein found in tissues and the circulation that regulates cell adhesion/migration and proteolytic cascades that govern hemostasis and pericellular proteolysis. Many of these functions occur via interactions with its binding partner, plasminogen activator inhibitor-1 (PAI-1), the chief inhibitor of proteases that lyse and activate plasminogen. We focused on a region of vitronectin that remains uncharacterized from previous X-ray scattering, nuclear magnetic resonance, and computational modeling approaches and which we propose is involved in binding to PAI-1. This region, which bridges the N-terminal …

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A New Climbing Shrew From Sulawesi Highlights The Tangled Taxonomy Of An Endemic Radiation, Jacob A. Esselstyn, Anang S. Achmadi, Heru Handika, Thomas C. Giarla, Kevin C. Rowe Dec 2019

A New Climbing Shrew From Sulawesi Highlights The Tangled Taxonomy Of An Endemic Radiation, Jacob A. Esselstyn, Anang S. Achmadi, Heru Handika, Thomas C. Giarla, Kevin C. Rowe

Faculty Publications

We describe a new species of Crocidura (Soricidae) from Sulawesi Island, Indonesia, documenting its novelty with both genetic and morphological characters. The new species is widespread on the island, with vouchered records from nine general localities distributed among five of the island's areas of endemism. Morphologically, the new species is readily distinguished from all other described Sulawesi Crocidura by its intermediate body size, gray pelage, and long, hairy tail. The new species was mainly captured in pitfalls placed in the ground, but we also obtained evidence that it readily climbs trees and may be scansorial in its locomotor habits. Populations …

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Divergent Trophic Responses Of Sympatric Penguin Species To Historic Anthropogenic Exploitation And Recent Climate Change, Kelton W. Mcmahon, Chantel I. Michelson, Tom Hart, Matthew D. Mccarthy, William P. Patterson, Michael J. Polito Dec 2019

Divergent Trophic Responses Of Sympatric Penguin Species To Historic Anthropogenic Exploitation And Recent Climate Change, Kelton W. Mcmahon, Chantel I. Michelson, Tom Hart, Matthew D. Mccarthy, William P. Patterson, Michael J. Polito

Faculty Publications

No abstract provided.

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Transcriptome-Wide Association Study Identifies Putative Elicitors/Suppressor Of Puccinia Graminis F. Sp. Tritici That Modulate Barley Rpg4-Mediated Stem Rust Resistance, Roshan Sharma Poudel, Jonathan Richards, Subidhya Shrestha, Shyam Solanki, Robert Brueggeman Dec 2019

Transcriptome-Wide Association Study Identifies Putative Elicitors/Suppressor Of Puccinia Graminis F. Sp. Tritici That Modulate Barley Rpg4-Mediated Stem Rust Resistance, Roshan Sharma Poudel, Jonathan Richards, Subidhya Shrestha, Shyam Solanki, Robert Brueggeman

Faculty Publications

Background: Stem rust is an economically important disease of wheat and barley. However, studies to gain insight into the molecular basis of these host-pathogen interactions have primarily focused on wheat because of its importance in human sustenance. This is the first extensive study utilizing a transcriptome-wide association mapping approach to identify candidate Puccinia graminis f. sp. tritici (Pgt) effectors/suppressors that elicit or suppress barley stem rust resistance genes. Here we focus on identifying Pgt elicitors that interact with the rpg4-mediated resistance locus (RMRL), the only effective source of Pgt race TTKSK resistance in barley. Results: Thirty-seven Pgt isolates showing differential …

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Monitoring The Growth Dynamics Of Colloidal Gold-Silver Core-Shell Nanoparticles Using In Situ Second Harmonic Generation And Extinction Spectroscopy, Jeewan C. Ranasinghe, Asela S. Dikkumbura, Prakash Hamal, Min Chen, Rami A. Khoury, Holden T. Smith, Kenneth Lopata, Louis H. Haber Dec 2019

Monitoring The Growth Dynamics Of Colloidal Gold-Silver Core-Shell Nanoparticles Using In Situ Second Harmonic Generation And Extinction Spectroscopy, Jeewan C. Ranasinghe, Asela S. Dikkumbura, Prakash Hamal, Min Chen, Rami A. Khoury, Holden T. Smith, Kenneth Lopata, Louis H. Haber

Faculty Publications

© 2019 Author(s). The growth dynamics of gold-silver core-shell (Au@Ag) nanoparticles are studied using in situ time-dependent second harmonic generation (SHG) and extinction spectroscopy to investigate the nanoparticle shell formation. The silver shell is grown by reduction of silver cations onto a 14 nm gold core using ascorbic acid in colloidal aqueous solution under varying reaction concentrations producing Au@Ag nanoparticles of final sizes ranging from 51 to 78 nm in diameter. The in situ extinction spectra show a rapid increase in intensity on the timescale of 5-6 s with blue shifting and narrowing of the plasmonic peak during the silver …

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Development And Evaluation Of A One-Step Multiplex Real-Time Taqman® Rt-Qpcr Assay For The Detection And Genotyping Of Equine G3 And G14 Rotaviruses In Fecal Samples, Mariano Carossino, Maria E. Barrandeguy, Erdal Erol, Yanqiu Li, Udeni B. R. Balasuriya Dec 2019

Development And Evaluation Of A One-Step Multiplex Real-Time Taqman® Rt-Qpcr Assay For The Detection And Genotyping Of Equine G3 And G14 Rotaviruses In Fecal Samples, Mariano Carossino, Maria E. Barrandeguy, Erdal Erol, Yanqiu Li, Udeni B. R. Balasuriya

Faculty Publications

No abstract provided.

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Do Global Regulators Hold The Key To Production Of Bacterial Secondary Metabolites?, Sudarshan Singh Thapa, Anne Grove Dec 2019

Do Global Regulators Hold The Key To Production Of Bacterial Secondary Metabolites?, Sudarshan Singh Thapa, Anne Grove

Faculty Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus Burkholderia has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle …

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Combinatorial Delivery Of Mirna-Nanoparticle Conjugates In Human Adipose Stem Cells For Amplified Osteogenesis, Mohammad Abu-Laban, Prakash Hamal, Julien H. Arrizabalaga, Anoosha Forghani, Asela S. Dikkumbura, Raju R. Kumal, Louis H. Haber, Daniel J. Hayes Dec 2019

Combinatorial Delivery Of Mirna-Nanoparticle Conjugates In Human Adipose Stem Cells For Amplified Osteogenesis, Mohammad Abu-Laban, Prakash Hamal, Julien H. Arrizabalaga, Anoosha Forghani, Asela S. Dikkumbura, Raju R. Kumal, Louis H. Haber, Daniel J. Hayes

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim It is becoming more apparent in tissue engineering applications that fine temporal control of multiple therapeutics is desirable to modulate progenitor cell fate and function. Herein, the independent temporal control of the co-delivery of miR-148b and miR-21 mimic plasmonic nanoparticle conjugates to induce osteogenic differentiation of human adipose stem cells (hASCs), in a de novo fashion, is described. By applying a thermally labile retro-Diels–Alder caging and linkage chemistry, these miRNAs can be triggered to de-cage serially with discrete control of activation times. The method relies on illumination of the nanoparticles at …

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Plant-Mediated Interactions Among Above-Ground And Below-Ground Life Stages Of A Root-Feeding Weevil, Emily C. Kraus, Michael J. Stout Dec 2019

Plant-Mediated Interactions Among Above-Ground And Below-Ground Life Stages Of A Root-Feeding Weevil, Emily C. Kraus, Michael J. Stout

Faculty Publications

© 2019 The Royal Entomological Society 1. Interactions among herbivores mediated by plant responses to herbivore injury may have large impacts on herbivore population densities. Responses may persist for weeks after injury and may affect not only the initial (inducing) herbivore, but also herbivores that are spatially or temporally separated from the initial attacker. 2. In many plant–insect interactions, multiple life stages of the insect may be associated with the same plant, and these various stages may interact indirectly with one another via induced responses. The rice water weevil (RWW), Lissorhoptrus oryzophilus, a serious global pest of rice, is one …

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Anti-Viral Immunity In The Tumor Microenvironment: Implications For The Rational Design Of Herpes Simplex Virus Type 1 Oncolytic Virotherapy, Paul J.F. Rider, Ifeanyi K. Uche, Larissa Sweeny, Konstantin G. Kousoulas Dec 2019

Anti-Viral Immunity In The Tumor Microenvironment: Implications For The Rational Design Of Herpes Simplex Virus Type 1 Oncolytic Virotherapy, Paul J.F. Rider, Ifeanyi K. Uche, Larissa Sweeny, Konstantin G. Kousoulas

Faculty Publications

© 2019, Springer Nature Switzerland AG. Purpose of Review: The design of novel herpes simplex type I (HSV-1)–derived oncolytic virotherapies is a balancing act between safety, immunogenicity, and replicative potential. We have undertaken this review to better understand how these considerations can be incorporated into rational approaches to the design of novel herpesvirus oncolytic virotherapies. Recent Findings: Several recent papers have demonstrated that enhancing the potential of HSV-1 oncolytic viruses to combat anti-viral mechanisms present in the tumor microenvironment leads to greater efficacy than their parental viruses. Summary: It is not entirely clear how the immunosuppressive tumor microenvironment affects oncolytic …

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One Week Of Continuous Corticosterone Exposure Impairs Hepatic Metabolic Flexibility, Promotes Islet Β-Cell Proliferation, And Reduces Physical Activity In Male C57bl/6 J Mice, Susan J. Burke, Heidi M. Batdorf, Tai Yu Huang, Joseph W. Jackson, Katarina A. Jones, Thomas M. Martin, Kristen E. Rohli, Michael D. Karlstad, Tim E. Sparer, David H. Burk, Shawn R. Campagna, Robert C. Noland, Paul L. Soto, J. Jason Collier Dec 2019

One Week Of Continuous Corticosterone Exposure Impairs Hepatic Metabolic Flexibility, Promotes Islet Β-Cell Proliferation, And Reduces Physical Activity In Male C57bl/6 J Mice, Susan J. Burke, Heidi M. Batdorf, Tai Yu Huang, Joseph W. Jackson, Katarina A. Jones, Thomas M. Martin, Kristen E. Rohli, Michael D. Karlstad, Tim E. Sparer, David H. Burk, Shawn R. Campagna, Robert C. Noland, Paul L. Soto, J. Jason Collier

Faculty Publications

© 2019 Elsevier Ltd Clinical glucocorticoid use, and diseases that produce elevated circulating glucocorticoids, promote drastic changes in body composition and reduction in whole body insulin sensitivity. Because steroid-induced diabetes is the most common form of drug-induced hyperglycemia, we investigated mechanisms underlying the recognized phenotypes associated with glucocorticoid excess. Male C57BL/6 J mice were exposed to either 100ug/mL corticosterone (cort) or vehicle in their drinking water. Body composition measurements revealed an increase in fat mass with drastically reduced lean mass during the first week (i.e., seven days) of cort exposure. Relative to the vehicle control group, mice receiving cort had …

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Integrated Solid-State Nmr And Molecular Dynamics Modeling Determines Membrane Insertion Of Human Β-Defensin Analog, Xue Kang, Christopher Elson, Jackson Penfield, Alex Kirui, Adrian Chen, Liqun Zhang, Tuo Wang Dec 2019

Integrated Solid-State Nmr And Molecular Dynamics Modeling Determines Membrane Insertion Of Human Β-Defensin Analog, Xue Kang, Christopher Elson, Jackson Penfield, Alex Kirui, Adrian Chen, Liqun Zhang, Tuo Wang

Faculty Publications

© 2019, The Author(s). Human β-defensins (hBD) play central roles in antimicrobial activities against various microorganisms and in immune-regulation. These peptides perturb phospholipid membranes for function, but it is not well understood how defensins approach, insert and finally disrupt membranes on the molecular level. Here we show that hBD-3 analogs interact with lipid bilayers through a conserved surface that is formed by two adjacent loops in the solution structure. By integrating a collection of 13C, 1H and 31P solid-state NMR methods with long-term molecular dynamic simulations, we reveal that membrane-binding rigidifies the peptide, enhances structural polymorphism, and promotes β-strand conformation. …

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Recurrent Fires Do Not Affect The Abundance Of Soil Fungi In A Frequently Burned Pine Savanna, Paige M. Hansen, Tatiana A. Semenova-Nelsen, William J. Platt, Benjamin A. Sikes Dec 2019

Recurrent Fires Do Not Affect The Abundance Of Soil Fungi In A Frequently Burned Pine Savanna, Paige M. Hansen, Tatiana A. Semenova-Nelsen, William J. Platt, Benjamin A. Sikes

Faculty Publications

© 2019 Elsevier Ltd and British Mycological Society While the negative effects of infrequent, high-intensity fire on soil fungal abundance are well-understood, it remains unclear how the short-term history of frequent, low-intensity fire in fire-dependent ecosystems impacts abundance, and whether this history governs any abundance declines. We used prescribed fire to experimentally alter the short-term fire history of patches within a fire-frequented old-growth pine savanna over a 3 y period. We then quantified fungal abundance before and after the final fire using phospholipid fatty acid (PLFA) assays and Droplet Digital™ PCR (ddPCR). Short-term fire history largely did not affect total …

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Elevated Levels Of Type 2 Respiratory Innate Lymphoid Cells In Human Infants With Severe Respiratory Syncytial Virus Bronchiolitis, Luan D. Vu, David Siefker, Tamekia L. Jones, Dahui You, Ryleigh Taylor, John Devincenzo, Stephania A. Cormier Dec 2019

Elevated Levels Of Type 2 Respiratory Innate Lymphoid Cells In Human Infants With Severe Respiratory Syncytial Virus Bronchiolitis, Luan D. Vu, David Siefker, Tamekia L. Jones, Dahui You, Ryleigh Taylor, John Devincenzo, Stephania A. Cormier

Faculty Publications

© 2019 by the American Thoracic Society. Rationale: Studies of the immune responses at the site of respiratory syncytial virus (RSV) infection are sparse despite nearly five decades of research into understanding RSV disease. Objectives: To investigate the role of mucosal innate immune responses to RSV and respiratory viral load in infants hospitalized with the natural disease. Methods: Cytokines, viral load, and type 2 innate lymphoid cell (ILC2) levels in nasal aspirates, collected within 24 hours of enrollment, from infants hospitalized with RSV infection were quantified. Measurements and Main Results: RSV severity in infants was categorized based on admission to …

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A Review Of Interactions Between Insect Biological Control Agents And Semiochemicals, Anamika Sharma, Ramandeep Kaur Sandhi, Gadi V.P. Reddy Dec 2019

A Review Of Interactions Between Insect Biological Control Agents And Semiochemicals, Anamika Sharma, Ramandeep Kaur Sandhi, Gadi V.P. Reddy

Faculty Publications

Biological control agents and semiochemicals have become essential parts of the integrated pest management of insect pests over recent years, as the incorporation of semiochemicals with natural enemies and entomopathogenic microbials has gained significance. The potential of insect pheromones to attract natural enemies has mainly been established under laboratory conditions, while semiochemicals from plants have been used to attract and retain natural enemies in field conditions using strategies such as trap crops and the push–pull mechanism. The best-known semiochemicals are those used for parasitoids–insect pest–plant host systems. Semiochemicals can also aid in the successful dispersal of entomopathogenic microbials. The use …

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From The Arctic To The Tropics: Multibiome Prediction Of Leaf Mass Per Area Using Leaf Reflectance, Shawn P. Serbin, Jin Wu, Kim S. Ely, Eric L. Kruger, Philip A. Townsend, Ran Meng, Brett T. Wolfe, Adam Chlus, Zhihui Wang, Alistair Rogers Dec 2019

From The Arctic To The Tropics: Multibiome Prediction Of Leaf Mass Per Area Using Leaf Reflectance, Shawn P. Serbin, Jin Wu, Kim S. Ely, Eric L. Kruger, Philip A. Townsend, Ran Meng, Brett T. Wolfe, Adam Chlus, Zhihui Wang, Alistair Rogers

Faculty Publications

Leaf mass per area (LMA) is a key plant trait, reflecting tradeoffs between leaf photosynthetic function, longevity, and structural investment. Capturing spatial and temporal variability in LMA has been a long-standing goal of ecological research and is an essential component for advancing Earth system models. Despite the substantial variation in LMA within and across Earth's biomes, an efficient, globally generalizable approach to predict LMA is still lacking. We explored the capacity to predict LMA from leaf spectra across much of the global LMA trait space, with values ranging from 17 to 393 g m−2. Our dataset contained leaves from a …

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Spatiotemporal Variability Of Fire Characteristics Affect Animal Responses In Pyric Landscapes, Bradley S. Cohen, Thomas J. Prebyl, Bret A. Collier, Michael J. Chamberlain Dec 2019

Spatiotemporal Variability Of Fire Characteristics Affect Animal Responses In Pyric Landscapes, Bradley S. Cohen, Thomas J. Prebyl, Bret A. Collier, Michael J. Chamberlain

Faculty Publications

Background: Behavioral responses are the most immediate ways animals interact with their environment, and are primary mechanisms by which individuals mitigate mortality risk while ensuring reproductive success. In disturbance-driven landscapes, animals must adjust behaviors both spatially and temporally to maximize individual fitness. Prescribed fire is an important ecosystem driver in many coniferous forests, as fire cycles nutrients, creates spatially heterogeneous distributions in quantity and quality of forage and cover, and provides opportunities for fire-adapted taxa. Because fire immediately shifts resource distribution, and fire characteristics may drive behavioral responses to recent burns, we examined behavioral responses of 105 Global Positioning System …

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