Digital Commons Network^™

Female Mice Are Protected From Metabolic Decline Associated With Lack Of Skeletal Muscle Hur, Allison C. Stone, Robert C. Noland, Randall L. Mynatt, Samuel E. Velasquez, David S. Bayless, Eric Ravussin, Jaycob D. Warfel

Division of Basic Science Faculty Publications

Male mice lacking HuR in skeletal muscle (HuRm−/−) have been shown to have decreased gastrocnemius lipid oxidation and increased adiposity and insulin resistance. The same consequences have not been documented in female HuRm−/− mice. Here we examine this sexually dimorphic phenotype. HuRm−/− mice have an increased fat mass to lean mass ratio (FM/LM) relative to controls where food intake is similar. Increased body weight for male mice correlates with increased blood glucose during glucose tolerance tests (GTT), suggesting increased fat mass in male HuRm−/− mice as a driver of decreased glucose clearance. However, HuRm−/− female mice show decreased blood glucose …

Hepatic Nfe2l2 Is Not An Essential Mediator Of The Metabolic Phenotype Produced By Dietary Methionine Restriction, Han Fang, Kirsten P. Stone, Sujoy Ghosh, Laura A. Forney, Landon C. Sims, Leighann Vincik, Thomas W. Gettys

Division of Basic Science Faculty Publications

The principal sensing of dietary methionine restriction (MR) occurs in the liver, where it activates multiple transcriptional programs that mediate various biological components of the response. Hepatic Fgf21 is a key target and essential endocrine mediator of the metabolic phenotype produced by dietary MR. The transcription factor, Nfe2l2, is also activated by MR and functions in tandem with hepatic Atf4 to transactivate multiple, antioxidative components of the integrated stress response. However, it is unclear whether the transcriptional responses linked to Nfe2l2 activation by dietary MR are essential to the biological efficacy of the diet. Using mice with liver-specific deletion of …

Human Plasma Proteomic Profiles Indicative Of Cardiorespiratory Fitness, Jeremy M. Robbins, Bennet Peterson, Daniela Schranner, Usman A. Tahir, Theresa Rienmüller, Shuliang Deng, Michelle J. Keyes, Daniel H. Katz, Pierre M.Jean Beltran, Jacob L. Barber, Christian Baumgartner, Steven A. Carr, Sujoy Ghosh, Changyu Shen, Lori L. Jennings, Robert Ross, Mark A. Sarzynski, Claude Bouchard, Robert E. Gerszten

Division of Basic Science Faculty Publications

Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO2max, and of increases of VO2max in response to exercise training (ΔVO2max), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise intervention and identify 147 proteins and 102 proteins whose plasma levels are associated with baseline VO2max and ΔVO2max, respectively. Addition of a protein biomarker score derived from these proteins to a score based on clinical traits improves …

Load Balancing For Distributed Nonlocal Models Within Asynchronous Many-Task Systems, Pranav Gadikar, Patrick Diehl, Prashant K. Jha

Faculty Publications

In this work, we consider the challenges of developing a distributed solver for models based on nonlocal interactions. In nonlocal models, in contrast to the local model, such as the wave and heat partial differential equations, the material interacts with neighboring points on a larger-length scale compared to the mesh discretization. In developing a fully distributed solver, the interaction over a length scale greater than mesh size introduces additional data dependencies among the compute nodes and communication bottleneck. In this work, we carefully look at these challenges in the context of nonlocal models; to keep the presentation specific to the …

Obesity And Cancer Risk In White And Black Adults: A Prospective Cohort Study, Justin C. Brown, Shengping Yang, Emily F. Mire, Xiaocheng Wu, Lucio Miele, Augusto Ochoa, Jovanny Zabaleta, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Objective: Anthropometric measures of obesity, including BMI and waist circumference (WC), do not quantify excess adiposity and metabolic abnormalities consistently across racial populations. This study tested the hypothesis that participant race modifies the association of anthropometric measures of obesity and cancer risk. Methods: This prospective cohort (The Pennington Center Longitudinal Study) included 18,296 adults, 6,405 (35.0%) male sex and 6,273 (34.3%) Black race. The primary exposures were BMI (weight in kilograms/height in meters squared) and WC (centimeters). The primary end point was the time from study enrollment to diagnosis of histologically confirmed invasive cancer. Results: During a median follow-up of …

Oocyte Specific Lncrna Variant Rose Influences Oocyte And Embryo Development, Rajan Iyyappan, Daria Aleshkina, Linkai Zhu, Zongliang Jiang, Veronika Kinterova, Andrej Susor

Faculty Publications

Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain either transcriptional noise or important contributors to cellular physiology. Despite the expanding number of studies related to lncRNAs, their influence on oocyte physiology remains enigmatic. We found an oocyte specific antisense, long non-coding RNA, “Rose” (lncRNA in Oocyte Specifically Expressed) expressed in two variants containing two and three non-coding exons, respectively. Rose is localized in the nucleus of transcriptionally active oocyte and in embryo with polysomal occupancy in …

Hyperpolarized Magnetic Resonance And Artificial Intelligence: Frontiers Of Imaging In Pancreatic Cancer, José S. Enriquez, Yan Chu, Shivanand Pudakalakatti, Kang Lin Hsieh, Duncan Salmon, Prasanta Dutta, Niki Zacharias Millward, Eugene Lurie, Steven Millward, Florencia Mcallister, Anirban Maitra, Subrata Sen, Ann Killary, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shayan Shams

Faculty Publications

Background: There is an unmet need for noninvasive imaging markers that can help identify the aggressive subtype(s) of pancreatic ductal adenocarcinoma (PDAC) at diagnosis and at an earlier time point, and evaluate the efficacy of therapy prior to tumor reduction. In the past few years, there have been two major developments with potential for a significant impact in establishing imaging biomarkers for PDAC and pancreatic cancer premalignancy: (1) hyperpolarized metabolic (HP)-magnetic resonance (MR), which increases the sensitivity of conventional MR by over 10,000-fold, enabling real-time metabolic measurements; and (2) applications of artificial intelligence (AI). Objective: Our objective of this review …

Disentangling The Effects Of Vapor Pressure Deficit And Soil Water Availability On Canopy Conductance In A Seasonal Tropical Forest During The 2015 El Niño Drought, Yilin Fang, L. Ruby Leung, Brett T. Wolfe, Matteo Detto, Ryan G. Knox, Nate G. Mcdowell, Charlotte Grossiord, Chonggang Xu, Bradley O. Christoffersen, Pierre Gentine, Charles D. Koven, Jeffrey Q. Chambers

Faculty Publications

Water deficit in the atmosphere and soil are two key interactive factors that constrain transpiration and vegetation productivity. It is not clear which of these two factors is more important for the water and carbon flux response to drought stress in ecosystems. In this study, field data and numerical modeling were used to isolate their impact on evapotranspiration (ET) and gross primary productivity (GPP) at a tropical forest site in Barro Colorado Island (BCI), Panama, focusing on their response to the drought induced by the El Niño event of 2015–2016. Numerical simulations were performed using a plant hydrodynamic scheme (HYDRO) …

Mixed (F)Ixed Messages, Lauren A. Verrett

LSU Master's Theses

Many individuals have an understanding that our lives have a timeline, and this timeline is full of objectives that we perceive as absolutes. Through personal observations it has become apparent that there are many amazing men and woman that are stagnant because they were raised to believe that meeting these goalposts are a priority. In an age of individualism, it is evident that every individual has control of their own life through their actions. However, in this same age of technology and social media, the anxiety of not meeting certain requirements or standards is even more apparent than previous generations. …

Assessment Of Endogenous Biomass Decay As A Source Of Precursors For Microbially-Mediated Toluene And P-Cresol Production, Samuel J. Reynolds

LSU Master's Theses

The research reported in this thesis was conducted to investigate whether protein hydrolysis associated with endogenous decay of biomass produced following the addition of a readily fermentable substrate is a potential source of precursors that can ultimately be transformed to toluene and p-cresol in environments undergoing enhanced bioremediation.

A packed column intended to represent a laboratory-scale section of an aquifer was seeded with groundwater and then supplied with molasses-amended groundwater for a two-day interval. The injected molasses concentration and surface loading rate were selected to be representative of conditions in the vicinity of injection wells at a Superfund Site …

Body/Mind:Matter, Mary Ellen Ratcliff

LSU Master's Theses

Body/Mind:Matter presents the unfiltered experiences of living in a period of momentous instability. Three life-sized figurative sculptures stage my emotional journey towards mindfulness as a direct response to the pandemic and my growing concern for our collective future. A winding network of crocheted yarns and growing vines interweave the troubled figures to signify our complex dependencies upon one another and our environment.

The condition of the encumbered bodies is a result of the worried mind. Revitalized matter proposes reconciliation by introducing a sense of hope; decaying surfaces reveal new life; fused wires hold up under immense pressure; and soft woven …

Penguins Past And Present: Trace Elements, Stable Isotopes, And Population Dynamics In Antarctic And Sub-Antarctic Penguins And Seals, Allyson K. Kristan

LSU Master's Theses

Antarctica and the sub-Antarctic are remote regions where the impacts from climate change and anthropogenic activities are increasingly apparent. Previous studies show that the Antarctic is warming and has been affected by anthropogenic contaminants. Marine predators such as penguins and seals are commonly used in these regions as sentinels of ecosystem health as predator tissues can be used as non-invasive proxies of diet, population trends, and contaminant exposure. This thesis includes two separate studies which investigate the influence of climate change and human activity on Antarctic and sub-Antarctic ecosystems. First, Adelie penguin (Pygoscelis adeliae) eggshell samples were collected …

Ecosytem Services: Delivering Decision-Making For Salt Marshes, Philine S. E. Zu Ermgassen, Ronald Baker, Michael W. Beck, Kate Dodds, Sophus O. S. E. Zu Ermgassen, Debbrota Mallick, Matthew D. Taylor, R. Eugene Turner

Faculty Publications

No abstract provided.

Implementation Of Dietary Methionine Restriction Using Casein After Selective, Oxidative Deletion Of Methionine, Han Fang, Kirsten P. Stone, Laura A. Forney, Landon C. Sims, Gabriela C. Gutierrez, Sujoy Ghosh, Thomas W. Gettys

Division of Basic Science Faculty Publications

Dietary methionine restriction (MR) is normally implemented using diets formulated from elemental amino acids (AA) that reduce methionine content to ∼0.17%. However, translational implementation of MR with elemental AA-based diets is intractable due to poor palatability. To solve this problem and restrict methionine using intact proteins, casein was subjected to mild oxidation to selectively reduce methionine. Diets were then formulated using oxidized casein, adding back methionine to produce a final concentration of 0.17%. The biological efficacy of dietary MR using the oxidized casein (Ox Cas) diet was compared with the standard elemental MR diet in terms of the behavioral, metabolic, …

Evidence For Perchlorate-Coupled Molybdenum And Nickel Carbon Monoxide Dehydrogenase Co Oxidation And Characterization Of Novel Perchlorate-Reducing Haloarchaea, Marisa Russell Myers

LSU Doctoral Dissertations

Carbon monoxide (CO) has been exploited as a microbial energy source for much of life’s evolutionary history. A phylogenetically diverse array of microorganisms can oxidize CO using two distinct CO dehydrogenases, molybdenum-dependent (Mo-CODH) and nickel-dependent (Ni-CODH). Aerobes and facultative organisms contain Mo-CODHs which allow them to utilize oxygen as an electron acceptor in addition to alternatives such as nitrate and sulfate. Obligate anaerobic organisms contain Ni-CODHs, which oxidize CO at elevated concentrations, but cannot utilize oxygen. In systems where organic matter deposits are limited or absent, atmospheric trace gases such as CO are thought to assist in supporting the growth …

The Role Of School Sociocultural Factors On The Mental Health And Academic Competence Of Elementary Aged Children, Aijah Kai Baruti Goodwin

LSU Doctoral Dissertations

Due to the diversification of school systems, schools are being challenged to engage in more culturally responsive practices to meet the needs of diverse students. Therefore, this study utilized Gay’s (2002) model of culturally responsive teaching to assess the relationship between sociocultural factors and the academic competence and mental health of elementary-aged children. This study also aimed to investigate the mediating and moderating relationship that culturally responsive classroom practices play on children’s academic competence and mental health. One hundred thirty-one diverse parents (97.7%), and legal guardians (2.3%) with children in elementary school (M_age = 8.05) were recruited for participation …

Examining The Sustainability Of Restored Sub-Tidal Oyster Reefs In Coastal Louisiana, Sarah C. Leblanc

LSU Master's Theses

Climate related alterations and anthropogenic disturbance threaten the ecological integrity and sustainability of coastal estuaries. Many activities seek to restore and sustain these at-risk areas with the goal of restoring systems to historic patterns of succession and community development; however long-term monitoring of restoration projects remains limited. Additionally, restoration efforts aim to achieve certain success thresholds, however, these thresholds are often vague, absent, or inconsistent, and receive little long-term analyses following restoration. A key coastal engineer, the eastern oyster (Crassostrea virginica), provides multiple ecosystem services, but recent population decline has prompted investment in restoration. Restoration activities include cultch …

Mothering Across Borders: A Phenomenological Exploration Into The Work-Family Balance Experiences Of Jamaican Transnational Mothers In The United States, Phelecia Alecia Udoko

LSU Doctoral Dissertations

The U.S. is home to one of the largest Jamaican populations residing outside of Jamaica and comprises over 50% of the U.S.-Caribbean workforce. Despite this, the experiences of Jamaican mothers who balance domestic work and families abroad–a phenomenon known as transnational motherhood – is often overlooked in research on work-family balance. Currently, a need exists to further explore work-family balance (WFB) as the lack of it has been associated with negative organizational outcomes. The purpose of this dissertation is to understand the WFB experiences of Jamaican transnational mothers and to explore the role of institutional/national policies and culture on WFB …

The Relationship Between Type Of Parental First Concerns And Severity Of Developmental Delays In Toddlers With Autism Or Developmental Delay, Joshua J. Montrenes

LSU Master's Theses

Autism spectrum disorder (ASD) is characterized by impairments in social communication and the presence of restricted, repetitive behaviors. The impairments which are commonly associated with ASD manifest during early development as delayed speech or impaired social skills, for example. These early indicators are often noticed by parents who convey concern to medical professionals. Research has found associations between these early parental concerns and a later diagnosis of autism, noting their predictive validity. Research has yet to address the relationship between types of parental concerns and developmental functioning. This study examined whether certain parent reported concerns are more predictive of impaired …

Incorporating Life Into Living Shorelines: Can Gulf Ribbed Mussels Reduce Shoreline Erosion And Enhance Restoration Practices?, Jordan Logarbo

LSU Master's Theses

The gulf ribbed mussel (Geukensia granosissima) exists throughout the Gulf of Mexico and influences biotic and abiotic environmental attributes as an ecosystem engineer. Ribbed mussels are an important component of marsh ecosystems providing services including filtering particulate matter, depositing and transforming nutrients in the system, increasing soil strength via byssal threads and providing structure via their shells.

The spatial distribution of mussels along the marsh edge of Sister Lake, LA was investigated via a broad survey of 150 sites, in relation to elevation, exposure and vegetation percent cover. This survey was followed by a second survey at a …

Evolution Of Extreme Habitat Specialists In The Dark: Cavefishes And Anglerfishes, Pamela Hart

LSU Doctoral Dissertations

Extremophilic organisms are fascinating in that they thrive in physiologically demanding environments. Extreme habitats include subsurface caves and the deep sea, which share several qualities like low light and cold temperatures. Extremophiles have adapted bizarre characteristics that allow them to thrive in such harsh environments including eye and pigment loss (cavefishes) and development of a lure in anglerfishes. These traits are integral to the health and fitness of these organisms, yet the evolutionary history of these traits is unclear.

Cave adaptation has evolved repeatedly across the Tree of Life, famously leading to eye degeneration and loss, yet its macroevolutionary implications …

Machine Learning Methods For Depression Detection Using Smri And Rs-Fmri Images, Marzieh Sadat Mousavian

LSU Doctoral Dissertations

Major Depression Disorder (MDD) is a common disease throughout the world that negatively influences people’s lives. Early diagnosis of MDD is beneficial, so detecting practical biomarkers would aid clinicians in the diagnosis of MDD. Having an automated method to find biomarkers for MDD is helpful even though it is difficult. The main aim of this research is to generate a method for detecting discriminative features for MDD diagnosis based on Magnetic Resonance Imaging (MRI) data.

In this research, representational similarity analysis provides a framework to compare distributed patterns and obtain the similarity/dissimilarity of brain regions. Regions are obtained by either …

Mosquito Distribution And Stoichiometric Analysis Between Open And Closed Canopies In New Orleans Cemeteries, Rachel Rogers

LSU Master's Theses

Cemetery vases represent an important container habitat for mosquito larvae. Some species, like, Aedes albopictus and Aedes aegypti, prefer container habitats, whereas others, like Culex quinquefasciatus, will opportunistically use containers. In New Orleans, these three medically important vector species (Ae. albopictus Ae. aegypti, and Cx. quinquefasciatus) co-occur, despite a demonstrated competitive advantage of Ae. albopictus to the other two. Here we test the hypothesis that canopy cover from trees could be a mediating factor in driving mosquito assemblages in New Orleans, by influencing food sources, and the microclimate experienced by mosquito larvae. Samples from seven …

Error Prevention In Sensors And Sensor Systems, Pedro J. Chacon Dominguez

LSU Doctoral Dissertations

Achievements in all fields of engineering and fabrication methods have led towards optimization and integration of multiple sensing devices into a concise system. These advances have caused significant innovation in various commercial, industrial, and research efforts. Integrations of subsystems have important applications for sensor systems in particular. The need for reporting and real time awareness of a device’s condition and surroundings have led to sensor systems being implemented in a wide variety of fields. From environmental sensors for agriculture, to object characterization and biomedical sensing, the application for sensor systems has impacted all modern facets of innovation. With these innovations, …

Virtual Worlds: Social Interactions Among Online Gamers Through Voice Chat, Omar Bradley Ictech Ii

LSU Doctoral Dissertations

Online gaming scholarship has rarely focused on the micro sociological aspects of virtual worlds as much of the research on online games is undertaken by psychologists and scholars in other fields. When a sociological lens is employed in analyzing social interactions that occur in virtual worlds, new understandings of social phenomena in virtual worlds can come to light. My research draws upon multiple sociological theories to make sense of data collect via in-depth interviews and participant observations in an attempt to understand how voice chat influences relationship formation and maintenance, gender relations among online gamers, and how online gamers use …

Emerging Wetlands From River Diversions Can Sustain High Denitrification Rates In A Coastal Delta, Kiran Upreti, Victor H. Rivera-Monroy, Kanchan Maiti, Anne Giblin, James P. Geaghan

Faculty Publications

It is assumed that to treat excess NO3⁻ high soil organic matter content (%OM) is required to maintain high denitrification rates in natural or restored wetlands. However, this excess also represents a risk by increasing soil decomposition rates triggering peat collapse and wetland fragmentation. Here, we evaluated the role of %OM and temperature interactions controlling denitrification rates in eroding (Barataria Bay-BLC) and emerging (Wax Lake Delta-WLD) deltaic regions in coastal Louisiana using the isotope pairing (IPT) and N2:Ar techniques. We also assessed differences between total (direct denitrification + coupled nitrification-denitrification) and net (total denitrification minus nitrogen fixation) denitrification rates …

Time Lags: Insights From The U.S. Long Term Ecological Research Network, Edward B. Rastetter, Mark D. Ohman, Katherine J. Elliott, J. S. Rehage, Victor H. Rivera-Monroy, R. E. Boucek, Edward Castañeda-Moya, Tess M. Danielson, Laura Gough, Peter M. Groffman, C. Rhett Jackson, Chelcy Ford Miniat, Gaius R. Shaver

Faculty Publications

Ecosystems across the United States are changing in complex ways that are difficult to predict. Coordinated long-term research and analysis are required to assess how these changes will affect a diverse array of ecosystem services. This paper is part of a series that is a product of a synthesis effort of the U.S. National Science Foundation’s Long Term Ecological Research (LTER) network. This effort revealed that each LTER site had at least one compelling scientific case study about “what their site would look like” in 50 or 100 yr. As the site results were prepared, themes emerged, and the case …

An Efficient Alternative To The Cdc Gravid Trap For Southern House Mosquito (Diptera: Culicidae) Surveillance, Timothy D. Mcnamara, Thomas A. O'Shea-Wheller, Nicholas Delisi, Emily Dugas, Kevin A. Caillouet, Randy Vaeth, Dennis Wallette, Kristen Healy

Faculty Publications

West Nile virus (WNV) is the most prevalent arbovirus found throughout the United States. Surveillance of surface breeding Culex vectors involved in WNV transmission is primarily conducted using CDC Gravid traps. However, anecdotal claims from mosquito abatement districts in Louisiana assert that other trap types may be more suited to WNV surveillance. To test the validity of these assertions, we conducted a series of trapping trials and WNV surveillance over 3 yr to compare the efficacy of multiple trap types. First, we compared the CDC Gravid trap, CO2-baited New Standard Miniature Blacklight traps, and CO2-baited CDC light traps with either …

Citations Versus Expert Opinions: Citation Analysis Of Featured Reviews Of The American Mathematical Society, Lawrence Smolinsky, Daniel S. Sage, Aaron J. Lercher, Aaron Cao

Faculty Publications

Peer review and citation metrics are two means of gauging the value of scientific research, but the lack of publicly available peer review data makes the comparison of these methods difficult. Mathematics can serve as a useful laboratory for considering these questions because as an exact science, there is a narrow range of reasons for citations. In mathematics, virtually all published articles are post-publication reviewed by mathematicians in Mathematical Reviews (MathSciNet) and so the data set was essentially the Web of Science mathematics publications from 1993 to 2004. For a decade, especially important articles were singled out in Mathematical Reviews …

Heavy Metal-Resistant Filamentous Fungi As Potential Mercury Bioremediators, Cristina L. Văcar, Eniko Covaci, Somsubhra Chakraborty, Bin Li, David Weindorf, Tiberiu Frentiu, Marcel Pârvu, Dorina Podar

Faculty Publications

No abstract provided.