Digital Commons Network^™

A Saturated Map Of Common Genetic Variants Associated With Human Height, Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders U. Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D. Arias, Sarah E. Graham, Ronen E. Mukamel, Cassandra N. Spracklen, Xianyong Yin, Shyh Huei Chen, Teresa Ferreira, Heather H. Highland, Yingjie Ji, Tugce Karaderi, Kuang Lin, Kreete Lüll, Deborah E. Malden, Carolina Medina-Gomez, Moara Machado, Amy Moore, Sina Rüeger, Xueling Sim, Scott Vrieze, Tarunveer S. Ahluwalia, Masato Akiyama, Matthew A. Allison

Faculty Publications

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of …

Understanding Motivations Among Sustained Cooperative Extension Partners For Obesity Prevention In Rural Louisiana, Catherine R. Losavio

LSU Master's Theses

Louisiana consistently has one of the highest rates of obesity in the nation with higher concentrations of obesity in many rural parishes (i.e., counties). Due to over a century of visibility and engagement in rural communities, Cooperative Extension (Extension) is uniquely poised to reach remote rural communities disproportionately impacted by obesity. As Extension increases its use of community coalitions and implements its new National Framework for Health Equity and Well-Being, understanding motivations and communication preferences among long-term rural coalition partners for obesity prevention and health promotion has become essential for duplicating successful local-level policy, system, and environmental (PSE) changes. This …

Influence Of Hesperidin On The Physico-Chemical, Microbiological, And Sensory Characteristics Of Frozen Yogurt, Roberto Antonio Cedillos Hernández

LSU Master's Theses

Frozen yogurts contain yogurt culture bacteria which might impart health benefits to its consumers. Global frozen yogurt market sales are expected to grow 4.8% by 2028 which represents an important opportunity for the industry, consumers, and researchers. Polyphenols are metabolites found in plants which have antioxidant and anti-inflammatory properties and might prevent chronical diseases such as cancer, diabetes, and cardiovascular diseases. The objective of this study was to elucidate the effect of the polyphenol hesperidin on the physico-chemical, microbiological, and sensory characteristics of frozen yogurts. Hesperidin was incorporated in frozen yogurt at three concentrations (500, 250 and 125 mg/90g of …

"A Sort Of Pain, Which Is New": Unresolved Grief In British Romantic Literature, Eta Farmacelia Nurulhady

LSU Doctoral Dissertations

This dissertation examines the cultural phenomenon of mourning in relation to British Romantic Literature. In chapters on the work of William Wordsworth, Jane Austen, Felicia Hemans, and Charles Lamb, it argues that the Romantic period, as a time of increased mobility due to three revolutions, wars, and the expansion of empire, was a moment when unresolved grief became a common experience. Using the psychologist Pauline Boss’s concept of “ambiguous loss” as a lens for a new reading of British Romantic writing, and distinguishing this concept from the modern concept of “nostalgia,” this dissertation analyzes poetry, novels, and essays written by …

Synthesis Of Carbon Nanohoops And Macrocycles Via Alkyne Metathesis, Xin Zhou

LSU Doctoral Dissertations

Cycloparaphenyleneacetylene (CPPA) and cycloparaphenylene (CPP) are called carbon nanohoops; they are fully conjugated macrocycles with radially oriented aromatic groups. Though many syntheses of CPPA and CPP were reported, in the macrocyclization step, the yields were usually not satisfying, as the reactions were irreversible. Our group utilizes alkyne metathesis to address this problem. Chapter 1 provides backgrounds and an introduction to the carbon nanohoops and alkyne metathesis.

Chapter 2 details the synthesis of the [3]CPP⁴A and [3]CPP⁵A, with good macrocyclization yields via alkyne metathesis. This study showed the error-correction ability of alkyne metathesis, especially with nonsymmetric substrates. …

Simulation Modeling Of A High-Throughput Oyster Cryopreservation Pathway, Sarah Bodenstein, Isabelina Nahmens, Terrence R. Tiersch

Faculty Publications

The genetic resources of oysters in Louisiana and the Gulf of Mexico are threatened due to high unexplained oyster mortality. Germplasm repositories are collections of cryopreserved genetic material stored alongside associated information that are used to protect genetics resources and facilitate breeding programs in agricultural industries. Therefore, there is great need for oyster repositories. Development of repositories has been slow despite research on high-Throughput cryopreservation protocols because of logistical complexities. The goal of this study was to begin to address the gap between cryopreservation research and repository development in oyster aquaculture by modeling a cryopreservation protocol to understand and improve …

Household Salt Production By The Late Classic Maya: Underwater Excavations At Ta'ab Nuk Na, Heather Mckillop, E. Cory Sills

Faculty Publications

Salt is an essential commodity; archaeological remains around the world attest to the importance of its production, exchange and consumption. Often located in coastal locations, many production sites were submerged by rising seas, including the Paynes Creek Salt Works on the southern Belize coast. Survey and excavation of these sites has identified 'kitchens' for brine boiling, as well as Terminal Classic residential structures at Ek Way Nal. The authors report the discovery of an earlier residential building alongside salt kitchens at the nearby site of Ta'ab Nuk Na. This finding indicates that surplus household production began during the Late Classic, …

A Numerical And Machine Learning Investigation Of Water Quality In The Northern Gulf Of Mexico, From Estuaries To Shelf, Yanda Ou

LSU Doctoral Dissertations

In this study, numerical and machine learning (ML) models are developed and adapted to investigate the water quality of the Barataria Estuary and the Louisiana-Texas (LaTex) Shelf in northern Gulf of Mexico. By using a 3-D hydrodynamic ROMS model, the salinity variability of the Barataria Estuary is found highly influenced by the Mississippi River discharges and man-made river diversion systems. The Mississippi River freshwater can intrude into the estuary through the middle and the east passes. Sensitivity tests indicate that decreases in lower estuarine salinity due to the elevated Mississippi River discharges are more apparent than the salinity increases due …

Low Levels Of Hybridization Between Domestic And Wild Mallards Wintering In The Lower Mississippi Flyway, J. Brian Davis, Diana C. Outlaw, Kevin M. Ringelman, Richard M. Kaminski, Philip Lavretsky

Faculty Publications

The Mallard (Anas platyrhynchos) duck is a ubiquitous and socio-economically important game bird in North America. Despite their generally abundant midcontinent population, Mallards in eastern North America are declining, which may be partially explained by extensive hybridization with human-released domestically derived game-farm Mallards. We investigated the genetic composition of Mallards in the middle and lower Mississippi flyway, key wintering regions for the species. We found that nearly 30% of wild Mallards carried mitochondrial (mtDNA) haplotypes derived from domestic Mallards present in North America, indicating that the individuals had female game-farm Mallard lineage in their past; however, nuclear results identified only …

Probiotic Characteristics Of Streptococcus Thermophilus And Lactobacillus Delbrueckii Ssp. Bulgaricus As Influenced By Carao (Cassia Grandis), David Paz, Ricardo S. Aleman, Roberto Cedillos, Douglas W. Olson, Kayanush Aryana, Jhunior Marcia, Charles Boeneke

Faculty Publications

Carao is considered a functional ingredient since its bioactive compounds are meaningful in nutritional, pharmacological, and medicinal applications. The objective of this study was to determine the effects of carao pulp powder on the bacterial viability, acid tolerance, bile tolerance, and protease activity of S. thermophilus STI-06 and L. bulgaricus LB-12. M17 broth with 0.5% lactose and MRS broth were used for S. thermophilus and L. bulgaricus, respectively, for determining bacterial viability, acid tolerance, and bile tolerance. Skim milk was used to study the protease activity of both bacteria. The carao was added at 0 (control), 1.3, 2.6, and 5.3 …

Characterization Of Resistance To The Mexican Rice Borer (Lepidoptera: Crambidae) Among Sugarcane Cultivars, Leonardo D. Salgado, Blake E. Wilson, Hannah J. Penn, Randy T. Richard, Michael O. Way

Faculty Publications

Cultivar resistance is an essential management strategy for the Mexican rice borer, Eoreuma loftini (Dyar), in sugarcane in the USA, but resistance mechanisms are poorly understood. Resistance was evaluated among Louisiana’s (USA) commercial sugarcane cultivars and experimental clones through field screenings, greenhouse trials, and a diet incorporation assay. Cultivars L 01-299 and HoCP 85-845 had the lowest borer injury levels, while HoCP 00-950 and L 12-201 were among the most heavily injured in field and greenhouse trials. The variability of results between the two field trials suggests that a genotype × environment interaction might affect the expression of resistance. Oviposition …

Variability In Energy Expenditure Is Much Greater In Males Than Females, Lewis G. Halsey, Vincent Careau, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas

Faculty Publications

In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. Energy expenditure could exhibit particularly high greater male variation through a cumulative effect if those traits mostly exhibit greater male variation, or a lack of greater male variation if many of them do not. Sex differences in energy expenditure variation have been little explored. We analyzed a large database on energy expenditure in adult humans (1494 males and 3108 females) to investigate whether …

The Small Ras Superfamily Gtpase Rho4 Of The Maize Anthracnose Fungus Colletotrichum Graminicola Is Required For Β-1,3-Glucan Synthesis, Cell Wall Integrity, And Full Virulence, Ely Oliveira-Garcia, Lala Aliyeva-Schnorr, Alan De Oliveira Silva, Seif El Din Ghanem, Kathrin Thor, Edgar Peiter, Holger B. Deising

Faculty Publications

Small Ras superfamily GTPases are highly conserved regulatory factors of fungal cell wall biosynthesis and morphogenesis. Previous experiments have shown that the Rho4-like protein of the maize anthracnose fungus Colletotrichum graminicola, formerly erroneously annotated as a Rho1 protein, physically interacts with the β-1,3-glucan synthase Gls1 (Lange et al., 2014; Curr. Genet. 60:343–350). Here, we show that Rho4 is required for β-1,3-glucan synthesis. Accordingly, Δrho4 strains formed distorted vegetative hyphae with swellings, and exhibited strongly reduced rates of hyphal growth and defects in asexual sporulation. Moreover, on host cuticles, conidia of Δrho4 strains formed long hyphae with hyphopodia, rather than short …

Inheritance Of Resistance To Cry1a.105 In Helicoverpa Zea (Boddie) (Lepidoptera: Noctuidae), Wenbo Yu, Graham P. Head, Fangneng Huang

Faculty Publications

Cry1A.105 is a bioengineered Bacillus thuringiensis (Bt) insecticidal protein consisting of three domains derived from Cry1Ac, Cry1Ab, and Cry1F. It is one of the two pyramided Bt toxins expressed in the MON 89034 event, a commonly planted Bt maize trait in the Americas. Recent studies have documented that field resistance of the corn earworm, Helicoverpa zea (Boddie), to the Cry1A.105 toxin in maize plants has become widespread in the United States. To investigate the inheritance of resistance to Cry1A.105 in H. zea, two independent tests, each with various genetic crosses among susceptible and Cry1A.105-resistant populations, were performed. The responses of …

Louisiana Agriculture Fall, 2022

Louisiana Agriculture

Livestock industries contribute $2.5 billion to the state’s economy, and beef cattle production is one of the most important sectors of the state’s agricultural enterprise. LSU AgCenter researchers study how to improve cattle production at research stations across the state. AgCenter Extension agents in every parish connect producers with their findings.

In this issue of Louisiana Agriculture magazine, livestock agents and research faculty describe the many programs they have developed to educate cattle producers and help 4-H’ers raise and show animals. Producers discuss what they have learned from Master Cattleman classes, and writer V. Todd Miller details how some cattle …

Variability Of Carbon Export In The Lower Mississippi River During An Extreme Cold And Warm Year, Lee Potter, Y. Jun Xu

Faculty Publications

The Mississippi River (MR) discharges on average 474 km3 of water annually into the Northern Gulf of Mexico (NGOM) with a large quantity of carbon, playing a vital role in the ecosystem’s food chain and water quality. In this study, we analyzed exports of dissolved inorganic (DIC) and organic carbon (DOC) from January 2021 to December 2021, during which the contiguous United States experienced one of the coldest winters as well as the hottest summer on record. Bi-weekly in situ river measurements and water sampling were conducted in the lower MR at Baton Rouge in Louisiana, USA, approximately 368 km …

Microhabitat And Landscape Drivers Of Richness And Abundance Of Freshwater Mussels (Unionida: Unionidae) In A Coastal Plain River, Corinne T. Bird, Michael D. Kaller, Tiffany E. Pasco, William E. Kelso

Faculty Publications

Although rivers support significant unionid mussel (Unionida: Unionidae) diversity, Gulf of Mexico tributary rivers have been subject to changes in water quality and habitat due to altered watershed land use. We quantified mussel species richness and relative abundance and environmental factors in small tributary streams of the Pearl River, Mississippi-Louisiana. Freshwater mussel and habitat surveys were conducted at 27 stream sampling sites over two summers (9 sites revisited), and coverage of seven land use categories and seven geological categories above each reach were calculated. Mussels were patchily distributed (53% of sites sampled yielded mussels) and typically not abundant (only 26% …

Cryopreservation Of Hydractinia Symbiolongicarpus Sperm To Support Community-Based Repository Development For Preservation Of Genetic Resources, Aidan L. Huene, Jack C. Koch, Lucía Arregui, Yue Liu, Matthew L. Nicotra, Virginia M. Weis, Terrence R. Tiersch

Faculty Publications

Hydractinia symbiolongicarpus is an emerging model organism in which cutting-edge genomic tools and resources are being developed for use in a growing number of research fields. One limitation of this model system is the lack of long-term storage for genetic resources. The goal of this study was to establish a generalizable cryopreservation approach for Hydractinia that would support future repository development for other cnidarian species. Specific objectives were to: (1) characterize basic parameters related to sperm quality; (2) develop a generalizable approach for sperm collection; (3) assess the feasibility of in vitro fertilization (IVF) with sperm after refrigerated storage; (4) …

Social Influences On Physical Activity For Establishing Criteria Leading To Exercise Persistence, Ensela Mema, Everett S. Spain, Corby K. Martin, James O. Hill, R. Drew Sayer, Howard D. Mcinvale, Lee A. Evans, Nicholas H. Gist, Alexander D. Borowsky, Diana M. Thomas

Clinical Research Faculty Publications

Despite well-documented health benefits from exercise, a study on national trends in achieving the recommended minutes of physical activity guidelines has not improved since the guidelines were published in 2008. Peer interactions have been identified as a critical factor for increasing a population’s physical activity. The objective of this study is for establishing criteria for social influences on physical activity for establishing criteria that lead to exercise persistence. A system of differential equations was developed that projects exercise trends over time. The system includes both social and non-social influences that impact changes in physical activity habits and establishes quantitative conditions …

Integration Of Qtl Mapping And Whole Genome Sequencing Identifies Candidate Genes For Alkalinity Tolerance In Rice (Oryza Sativa), Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Prasanta K. Subudhi

Faculty Publications

Soil alkalinity is an important stressor that impairs crop growth and development, resulting in reduced crop productivity. Unlike salinity stress, research efforts to understand the mechanism of plant adaptation to alkaline stress is limited in rice, a major staple food for the world population. We evaluated a population of 193 recombinant inbred lines (RIL) developed from a cross between Cocodrie and N22 under alkaline stress at the seedling stage. Using a linkage map consisting of 4849 SNP markers, 42 additive QTLs were identified. There were seven genomic regions where two or more QTLs for multiple traits colocalized. Three important QTL …

Antimicrobial Resistant Bacteria In Shrimp And Shrimp Farms Of Bangladesh, Murshida Khan, Sulav Indra Paul, Md Mahbubur Rahman, Julie Anderson Lively

Faculty Publications

The purpose of this study was to investigate the presence of pathogenic bacteria, specifically Escherichia coli and Salmonella and Vibrio species, and their antimicrobial resistance in shrimp aquaculture facilities of Bagerhat (Bangladesh). Sediment samples were collected from both Penaeus monodon and Macrobrachium rosenbergii farms and shrimp samples from the Macrobrachium rosenbergii facility. The abovementioned bacteria were not found, but five Enterobacterales (Proteus penneri, Proteus alimentorum, Morganella morganii, Enterobacter hormaechei subsp. xiangfangensis and Plesiomonas shigelloides) were detected. This is the first documented case of Enterobacter hormaechei subsp. xiangfangensis in a shrimp farm. Nine antibiotics—ampicillin, gentamicin, chloramphenicol, oxytetracycline, nitrofurantoin, levofloxacin, ciprofloxacin, azithromycin, …

Novel Pcr-Based Multiplex Assays For Detecting Major Quality And Biotic Stress In Commercial And Weedy Rice, Noraikim Mohd Hanafiah, Acga Cheng, Phaik Eem Lim, Gomathy Sethuraman, Nurul Amalina Mohd Zain, Niranjan Baisakh, Muhamad Shakirin Mispan

Faculty Publications

While previous research has demonstrated that multiplex polymerase chain reaction (PCR) can be a cost-effective approach to detect various genes in crops, the availability of multiplex assays to simultaneously screen both grain quality and biotic stress resistance traits in rice (Oryza sativa) is limited. In this work, we report six novel multiplex assays that use a universal protocol to detect major rice grain quality (amylose content and fragrance) and biotic stress (blast, sheath blight, and bacterial leaf blight) traits with amplified products consisting of up to four primer pairs that can be analyzed using a standard agarose-based gel electrophoresis system. …

Event-Triggered Control Of Robotic Fish With Reduced Communication Rate, Wenyu Zuo, Animesh Chakravarthy, Michael Malisoff, Zheng Chen

Faculty Publications

Underwater robots often need to communicate with external localization sensors. The low bandwidth in such communications is one of the bottlenecks in achieving accurate tracking control. Toward this end, we adopt a novel periodic event-triggered control (PETC) which allows a robotic fish to reduce its communication load in tracking a desired heading angle with position feedback from an external sensor. To design the PETC, a linear state-space model is derived from a nonlinear dynamic model of the robotic fish with a small perturbation assumption. The PETC consists of an observer, state-feedback controller, integrator, event-trigger rule, and predictor. The observer and …

Academic Program Recommendations For Graduate Degrees In Medical Physics: Aapm Report No. 365 (Revision Of Report No. 197), Jay W. Burmeister, Nathan C. Busse, Ashley J. Cetnar, Rebecca R. Howell, Robert Jeraj, A. Kyle Jones, Steven H. King, Kenneth L. Matthews, Victor J. Montemayor, Wayne Newhauser, Anna E. Rodrigues, Ehsan Samei, Timothy V. Turkington, Mary P. Gronberg, Brian Loughery, Alison R. Roth, Michael C. Joiner, Edward F. Jackson, Paul A. Naine, Leonard H. Kim

Faculty Publications

No abstract provided.

Contrasts Among Cationic Phytochemical Landscapes In The Southern United States, Luis Y. Santiago-Rosario, Kyle E. Harms, Dylan Craven

Faculty Publications

Understanding the phytochemical landscapes of essential and nonessential chemical elements to plants provides an opportunity to better link biogeochemical cycles to trophic ecology. We investigated the formation and regulation of the cationic phytochemical landscapes of four key elements for biota: Ca, Mg, K, and Na. We collected aboveground tissues of plants in Atriplex, Helianthus, and Opuntia and adjacent soils from 51, 131, and 83 sites, respectively, across the southern United States. We determined the spatial variability of these cations in plants and soils. Also, we quantified the homeostasis coefficient for each cation and genus combination, by using mixed-effect models, with …

Effects Of Soil And Foliar Applied Fertilizers On Growth, Yield And Sugar Quality Of Two Sugarcane Cultivars Under Rainfed Conditions, J. Bamrungrai, A. Polthanee, B. Tubana, V. Tre-Loges, A. Promkhambut

Faculty Publications

Background: In north-eastern Thailand, sugarcane is planted normally in late rainy season wherein the plants may experience drought stress during its early growth stage in dry season and waterlogging stress during late growth stage at peak of rainy season. Hence, the objective of the present study was to investigate the effects of soil application alone and soil combined with foliar application of nutrients on growth, yield and sugar quality of sugarcane grown under rainfed conditions. Methods: The field experiment was conducted during November 2016 to December 2017. A split-plot design with three replications was laid out. The two sugarcane cultivars …

A Guide To Design The Trajectory Of Active Particles: From Fundamentals To Applications, Ahmed Al Harraq, Mustapha Bello, Bhuvnesh Bharti

Faculty Publications

Active particles convert external energy into motility, displaying a variety of dynamical features. Recent progress in the field has marked a shift in focus from understanding the origin and sources of active motion to controlling the dynamics and trajectory of individual microswimmers. This review explores the advancements made in a two-fold perspective—the role of particle design and that of external factors. Our main goal is to highlight the guiding principles, which determine active particle trajectory. These include, on the one hand, the role of the morphology of active particles and their assemblies in driving translation, rotation, and corresponding coupling between …

Genomic Basis For Individual Differences In Susceptibility To The Neurotoxic Effects Of Diesel Exhaust, Alexandra Noël, David G. Ashbrook, Fuyi Xu, Stephania A. Cormier, Lu Lu, James P. O’Callaghan, Shyam K. Menon, Wenyuan Zhao, Arthur L. Penn, Byron C. Jones

Faculty Publications

Air pollution is a known environmental health hazard. A major source of air pollution includes diesel exhaust (DE). Initially, research on DE focused on respiratory morbidities; however, more recently, exposures to DE have been associated with neurological developmental disorders and neurodegeneration. In this study, we investigated the effects of sub-chronic inhalation exposure to DE on neuroinflammatory markers in two inbred mouse strains and both sexes, including whole transcriptome examination of the medial prefrontal cortex. We exposed aged male and female C57BL/6J (B6) and DBA/2J (D2) mice to DE, which was cooled and diluted with HEPA-filtered compressed air for 2 h …

Rapid Evaluation And Optimization Of Carbon Dioxide-Enhanced Oil Recovery Using Reduced-Physics Proxy Models, Watheq J. Al-Mudhafar, Dandina N. Rao, Sanjay Srinivasan, Hung Vo Thanh, Erfan M. Al Lawe

Faculty Publications

The carbon dioxide (CO2) injection in oil reservoirs is a promising enhanced oil recovery method to reduce carbon emissions into the atmosphere. The CO2 injection simulation and optimization require a large computation time, especially in real large-scale oil reservoirs. This paper integrates experimental design and machine learning to construct a reduced-physics surrogate model alternative to the complex reservoir simulator. This surrogate model was used to evaluate and optimize the CO2-assisted gravity drainage (CO2-GAGD) process, applied to a clastic reservoir in the Rumaila oil field. In the GAGD process optimization, five operational decision parameters controlling the production and injection activities were …

A Numerical Reassessment Of The Gulf Of Mexico Carbon System In Connection With The Mississippi River And Global Ocean, Le Zhang, Z. George Xue

Faculty Publications

Coupled physical-biogeochemical models can fill the spatial and temporal gap in ocean carbon observations. Challenges of applying a coupled physical-biogeochemical model in the regional ocean include the reasonable prescription of carbon model boundary conditions, lack of in situ observations, and the oversimplification of certain biogeochemical processes. In this study, we applied a coupled physical-biogeochemical model (Regional Ocean Modelling System, ROMS) to the Gulf of Mexico (GoM) and achieved an unprecedented 20-year high-resolution (5 km, 1/22°) hindcast covering the period of 2000 to 2019. The biogeochemical model incorporated the dynamics of dissolved organic carbon (DOC) pools and the formation and dissolution …