Digital Commons Network^™

Regional Variation In Feeding Patterns Of Sheepshead (Archosargus Probatocephalus) In The Northwest Gulf Of Mexico, Elsa M. Gutierrez, Jeffrey D. Plumlee, Derek G. Bolser, Brad E. Erisman, R. J.David Wells

Faculty Publications

Feeding patterns of sheepshead, Archosargus probatocephalus, in the northwest Gulf of Mexico were examined from samples collected at two locations in Texas, USA; Galveston and Port Aransas. A total of 53 sheepshead stomachs (Galveston, n = 35; Port Aransas, n = 18) had their contents analyzed along with tissue samples from the muscle and liver for a stable isotope analysis (δ13C, δ15N, and δ34S) because they provide a contrast between short-term (liver) and long-term (muscle) measurements. Multiple species of amphipods made up the majority of the prey items in sheepshead from Galveston (%IRI = 61.79), whereas barnacles were the primary …

Low Species Turnover Of Upland Amazonian Birds In The Absence Of Physical Barriers, Cameron L. Rutt, W. Justin Cooper, Christian B. Andretti, Thiago V.V. Costa, Philip C. Stouffer, Claudeir F. Vargas, David A. Luther, Mario Cohn-Haft

Faculty Publications

Aim: One of the oldest and most powerful ways for ecologists to explain distinct biological communities is to invoke underlying environmental differences. But in hyper-diverse systems, which often display high species richness and low species abundance, these sorts of community comparisons are especially challenging. The classic view for Amazonian birds posits that riverine barriers and habitat specialization determine local and regional community composition. We test the tacit, complementary assumption that similar bird communities should therefore permeate uniform habitat between major rivers, regardless of distance. Location: Upland (terra firme) rainforests of central Amazonia. Methods: We conducted intensive whole-community surveys of birds …

Safety And Tolerability Of Whole Soybean Products: A Dose-Escalating Clinical Trial In Older Adults With Obesity, Candida J. Rebello, Stephen Boué, Ronald J. Levy, Renée Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan

Division of Basic Science Faculty Publications

Soybean products have nutrients, dietary fiber, and phytoalexins beneficial for cardiovascular and overall health. Despite their high consumption in Asian populations, their safety in Western diets is debated. We conducted a dose-escalating clinical trial of the safety and tolerability of soybean products in eight older adults (70–85 years) with obesity. Whole green soybean pods grown under controlled conditions were processed to flour (WGS) at the United States Department of Agriculture using common cooking techniques such as slicing and heat treatment. WGS incorporated into food products was consumed at 10 g, 20 g, and 30 g/day for one week at each …

Exercise In The Prevention And Treatment Of Type 2 Diabetes, John P. Kirwan, Elizabeth C. Heintz, Candida J. Rebello, Christopher L. Axelrod

Division of Basic Science Faculty Publications

Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the pre-disposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control.

Is The Gut Microbiome Implicated In The Excess Risk Of Hypertension Associated With Obstructive Sleep Apnea? A Contemporary Review, Sanah S. Munir, Fatima H. Sert Kuniyoshi, Prachi Singh, Naima Covassin

Clinical Research Faculty Publications

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, inflammation, and metabolic dysregulation. Among the mechanisms potentially involved in OSA-induced hypertension, the role of the gut microbiome is gaining increasing attention. Perturbations in the diversity, composition, and function of the gut microbiota have been causally linked to numerous disorders, and robust evidence has identified gut dysbiosis as a determinant of BP elevation in various populations. In this brief review, we summarize …

Total Daily Energy Expenditure Has Declined Over The Past Three Decades Due To Declining Basal Expenditure, Not Reduced Activity Expenditure, John R. Speakman, Jasper M.A. De Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma

Faculty Publications

Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. …

Stable Isotope Tracing Reveals An Altered Fate Of Glucose In N-Acetyltransferase 1 Knockout Breast Cancer Cells, James T.F. Wise, Xinmin Yin, Xipeng Ma, Xiang Zhang, David W. Hein

Faculty Publications

Breast cancer is one of the leading causes of cancer death. Recent studies found that arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer, further suggesting NAT1 could be a potential therapeutic target for breast cancer. Previous publications have established that NAT1 knockout (KO) in breast cancer cell lines leads to growth reduction both in vitro and in vivo and metabolic changes. These reports suggest that NAT1 contributes to the energy metabolism of breast cancer cells. Proteomic analysis and non-targeted metabolomics suggested that NAT1 KO may change the fate of glucose as it relates to the TCA/KREB cycle of …

Ecophysiology And Genomics Of The Brackish Water Adapted Sar11 Subclade Iiia, V. Celeste Lanclos, Anna N. Rasmussen, Conner Y. Kojima, Chuankai Cheng, Michael W. Henson, Brant C. Faircloth, Christopher A. Francis, J. Cameron Thrash

Faculty Publications

The Order Pelagibacterales (SAR11) is the most abundant group of heterotrophic bacterioplankton in global oceans and comprises multiple subclades with unique spatiotemporal distributions. Subclade IIIa is the primary SAR11 group in brackish waters and shares a common ancestor with the dominant freshwater IIIb (LD12) subclade. Despite its dominance in brackish environments, subclade IIIa lacks systematic genomic or ecological studies. Here, we combine closed genomes from new IIIa isolates, new IIIa MAGS from San Francisco Bay (SFB), and 460 highly complete publicly available SAR11 genomes for the most comprehensive pangenomic study of subclade IIIa to date. Subclade IIIa represents a taxonomic …

Mapping And Identification Of Molecular Markers For The Pc96 Gene Conferring Resistance To Crown Rust In Oat, Sidrat Abdullah, Gordon Tyler, Belayneh Admassu Yimer, Edyta Paczos-Grzęda, Stephen A. Harrison, James G. Menzies, Kathy Esvelt Klos

Faculty Publications

Oat crown rust caused by Puccinia coronata f. sp. avenae P. Syd. & Syd (Pca) is a major constraint to oat (Avena sativa L.) production in many parts of the globe. The objectives of this study were to locate Pc96 on the oat consensus map and to develop SNP markers linked to Pc96 for use in marker-assisted selection. SNP loci linked to the crown rust resistance gene Pc96 were identified by linkage analysis and PACE assays were developed for marker-assisted selection in breeding programs. Pc96 is a race-specific crown rust resistance gene originating from cultivated oat that has been deployed …

Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana

Faculty Publications

Consumers are becoming aware of functional ingredients such as medicinal herbs, polyphenols, mushrooms, amino acids, proteins, and probiotics more than ever before. Like yogurt and its probiotics, L-glutamine, quercetin, slippery elm bark, marshmallow root, N-acetyl-D-glucosamine, licorice root, maitake mushrooms, and zinc orotate have demonstrated health benefits through gut microbiota. The impact of these ingredients on yogurt starter culture bacteria characteristics is not well known. The objective of this study was to determine the influence of these ingredients on the probiotic characteristics, tolerance to gastric juices and lysozyme, protease activity, and viability of Streptococcus thermophilus STI-06 and Lactobacillus bulgaricus LB-12. Acid …

Genome-Wide Association Analysis Of Hyperspectral Reflectance Data To Dissect The Genetic Architecture Of Growth-Related Traits In Maize Under Plant Growth-Promoting Bacteria Inoculation, Rafael Massahiro Yassue, Giovanni Galli, Chun Peng James Chen, Roberto Fritsche-Neto, Gota Morota

Faculty Publications

Plant growth-promoting bacteria (PGPB) may be of use for increasing crop yield and plant resilience to biotic and abiotic stressors. Using hyperspectral reflectance data to assess growth-related traits may shed light on the underlying genetics as such data can help assess biochemical and physiological traits. This study aimed to integrate hyperspectral reflectance data with genome-wide association analyses to examine maize growth-related traits under PGPB inoculation. A total of 360 inbred maize lines with 13,826 single nucleotide polymorphisms (SNPs) were evaluated with and without PGPB inoculation; 150 hyperspectral wavelength reflectances at 386–1021 nm and 131 hyperspectral indices were used in the …

Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Details of the structural elucidation of the clinically useful photodynamic therapy sensitizer NPe6 (15) are presented. NPe6, also designated as Laserphyrin, Talaporfin, and LS-11, is a second-generation photosensitizer derived from chlorophyll-a, currently used in Japan for the treatment of human lung, esophageal, and brain cancers. After the initial misidentification of the structure of this chlorin-e6 aspartic acid conjugate as (13), NMR and other synthetic procedures described herein arrived at the correct structure (15), confirmed using single crystal X-ray crystallography. Interesting new features of chlorin-e6 chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate …

New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas

Faculty Publications

This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use …

North Flinders Reef (Coral Sea, Australia) Porites Sp. Corals As A Candidate Global Boundary Stratotype Section And Point For The Anthropocene Series, Jens Zinke, Neal E. Cantin, Kristine L. Delong, Kylie Palmer, Arnoud Boom, Irka Hajdas, Nicolas Duprey, Alfredo Martínez-García, Neil L. Rose, Sarah L. Roberts, Handong Yang, Lucy R. Roberts, Andrew B. Cundy, Pawel Gaca, James Andy Milton, Grace Frank, Adam Cox, Sue Sampson, Genevieve Tyrrell, Molly Agg, Simon D. Turner

Faculty Publications

Corals are unique in the suite of proposed Anthropocene Global Boundary Stratotype Section and Point (GSSP) archives, as living organisms that produce aragonite exoskeletons preserved in the geological record that contain highly accurate and precise (<±1 year) internal chronologies. The GSSP candidate site North Flinders Reef in the Coral Sea (Australia) is an offshore oceanic reef, and therefore less vulnerable to local human influences than those closer to the coast. Here, we present geochemical records from two Porites sp. corals sampled at an annual to pluri-annual (i.e. 3–5 years) resolution that shows clear global and regional human impacts. Atmospheric nuclear bomb testing by-products (14C,239+240Pu) show a clear increase in the Flinders Reef corals coincident with well-dated nuclear testing operations. By contrast, the radionuclides 241Am and 137Cs are present at low or undetectable levels, as are spheroidal carbonaceous fly-ash particles. Coral δ13C shows centennial variability likely influenced by growth effects in the 18th century and with a progression to lower values starting in 1880 CE and accelerating post-1970 CE. The latter may be related to the Suess effect resulting from 13C-depleted fossil fuel burning. Coral δ15N decreased between 1710 and 1954 CE with a reversal post-1954 CE. Coral temperature proxies indicate prominent centennial variability with equally warm conditions in the 18th and end of 20th century. However, the exact mechanisms responsible for the mid-20th century changes in these parameters need to be scrutinised in further detail. Plain Language summary: This work proposes a candidate natural archive for the official marker of the Anthropocene that geologists will use to mark this important interval in time. Our candidate is a live coral from North Flinders Reef in the Coral Sea (Australia), located 150 km east of the Great Barrier Reef, a location that is remote from direct local human influences. Corals are a unique archive of tropical ocean change because they incorporate the geochemical signature from seawater into their limestone skeleton during their long life-spans. Here we investigated a number of geochemical markers in yearly growth layers of the corals to define several markers for the Anthropocene based on changes in temperature, water chemistry, chemicals from pollution and fertilisers, radioactive products from nuclear bomb testing, and by-products from burning fossil fuels. We have detected clear human influences in several of these markers.

Constraints On The Timing And Extent Of Deglacial Grounding Line Retreat In West Antarctica, Ryan A. Venturelli, Brenna Boehman, Christina Davis, Jon R. Hawkings, Sarah E. Johnston, Chloe D. Gustafson, Alexander B. Michaud, Cyrille Mosbeux, Matthew R. Siegfried, Trista J. Vick-Majors, Valier Galy, Robert G.M. Spencer, Sophie Warny, Brent C. Christner, Helen A. Fricker, David M. Harwood, Amy Leventer, John C. Priscu, Brad E. Rosenheim

Faculty Publications

Projections of Antarctica's contribution to future sea level rise are associated with significant uncertainty, in part because the observational record is too short to capture long-term processes necessary to estimate ice mass changes over societally relevant timescales. Records of grounding line retreat from the geologic past offer an opportunity to extend our observations of these processes beyond the modern record and to gain a more comprehensive understanding of ice-sheet change. Here, we present constraints on the timing and inland extent of deglacial grounding line retreat in the southern Ross Sea, Antarctica, obtained via direct sampling of a subglacial lake located …

The Rise Of Machine Learning In Polymer Discovery, Cheng Yan, Guoqiang Li

Faculty Publications

In the recent decades, with rapid development in computing power and algorithms, machine learning (ML) has exhibited its enormous potential in new polymer discovery. Herein, the history of ML is described and the basic process of ML accelerated polymer discovery is summarized. Next, the four steps in this process are reviewed, that is, dataset selection, fingerprinting, ML framework, and new polymer generation. Finally, a couple of main challenges for ML accelerated polymer discovery is presented and the outlooks in this field are prospected. It is expected that this review can service as a useful tool for the people who just …

Corticosterone Measurement In A Cryptosporidium-Positive Population Of Louisiana Pine Snakes (Pituophis Ruthveni), Corinne Mayer

LSU Master's Theses

Louisiana pine snakes (Pituophis ruthveni) are one of the rarest snake species in North America, and federally classified as “threatened” (United States Fish and Wildlife, 2018). Recent establishment of sustainable captive breeding populations combined with decades of field research by conservation biologists has led to several advancements in our knowledge of this species; however, further investigations into health parameters and the physiology of this species are needed to optimize management of captive populations.

One recent investigation highlighted the difficulties in reliably differentiating the sexes in P. ruthveni using traditional tail probing techniques (Katz et al., 2020). Prior to …

Role Of Il-10 In Sars-Cov-2 Infection During Pregnancy, Natalie Lim

Honors Capstones

No abstract provided.

Characterization Of Swimming Patterns In Chlamydomonas Reinhardtii, Nathan Kratzberg

Honors Capstones

No abstract provided.

Sustainable Application Of Natural Industrial Byproducts As Manufacturing Materials, Aubry Hymel

Honors Capstones

No abstract provided.

Reproductive State-Dependent Activity Of The Dopaminergic System In The Retina Of Female Cichlid Fish, Astatotilapia Burtoni, Tab Henry

Honors Capstones

No abstract provided.

Exploring The Immunomodulatory Effects Of Localized Radiation Therapy In Dogs With Nasal Tumors, Christine Goodermuth

Honors Capstones

No abstract provided.

Calling It What It Is: Climate Change As A Key, Primary, And Direct Push Factor Of Migration In The Middle East And North Africa, Katie Cass

Honors Capstones

No abstract provided.

The Effect Of Maternal Ghrelin Levels On Infant Adiposity, Lacey Budd

Honors Capstones

No abstract provided.

Gas Hydrates Reserve Characterization Using Thermo-Hydro-Mechanical Numerical Simulation: A Case Study Of Green Canyon 955, Gulf Of Mexico, Sulav Dhakal, Ipsita Gupta

Faculty Publications

The Gulf of Mexico is a widely explored and producing region for offshore oil and gas resources, with significant submarine methane hydrates. Estimates of hydrate saturation and distribution rely on drilling expeditions and seismic surveys that tend to provide either large-scale estimates or highly localized well data. In this study, hydrate reserve characterization is done using numerical simulation at Green Canyon block 955 (GC955). In addition, coupled thermo-hydro-mechanical (THM) simulation results show that hydrate saturation and geobody distribution are determined by the thermodynamic conditions as well as reservoir structures, stratigraphic differences, and permeability differences. Hydrate formation due to upflow of …

Characterization Of The Acinetobacter Baumannii Deda Membrane Protein Family, Emily Evans

Honors Capstones

No abstract provided.

Europe Divided: An Analysis Of Country Characteristics And Rhetorical Influence On Migrant Acceptance Following The Syrian Migration Crisis, Reece Lantz

Honors Capstones

No abstract provided.

The Quantification Of Blue Colors In Several Species Of The Avian Phylogeny, Caroline Cresson

Honors Capstones

No abstract provided.

Inhibition Of Human Acetyl-Coa Carboxylase 2 Using Synthetic Intermediates Of The Natural Product Moiramide B From Pseudomonas Fluorescens, Kyle Becnel

Honors Capstones

No abstract provided.

The Effect Of Salt Stress On Root Development In Plants, August Steinkamp

Honors Capstones

No abstract provided.