Digital Commons Network^™

‘Avoyelles’ Sweetpotato, Don R. La Bonte, Imana Power, Tristan Watson, Tara P. Smith, Arthur Q. Villordon, Jeffrey Cole Gregorie, Lorin Harvey

Faculty Publications

No abstract provided.

Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan

Faculty Publications

Clanis bilineata Walker (Lepidoptera: Sphingidae), a burgeoning edible insect, is experiencing rising demand in China and other regions. Despite this interest, larval production is currently constrained by the limitations of artificial production technologies, particularly the selection of optimal host plants. This study rigorously evaluated the performance of C. bilineatha larvae on four main host plants: round-leaf soybean, pointed-leaf soybean, black locust, and kudzu. Preference tests demonstrated that the larvae were most attracted to black locust (34.76 ± 4.65%), with subsequent preferences for kudzu (25.00 ± 6.12%), round-leaf soybean (23.17 ± 2.79%), and pointed-leaf soybean (14.02 ± 4.74%). No significant preference …

Adaptive Phase I–Ii Clinical Trial Designs Identifying Optimal Biological Doses For Targeted Agents And Immunotherapies, Yong Zang, Beibei Guo, Yingjie Qiu, Hao Liu, Mateusz Opyrchal, Xiongbin Lu

Faculty Publications

Targeted agents and immunotherapies have revolutionized cancer treatment, offering promising options for various cancer types. Unlike traditional therapies the principle of “more is better” is not always applicable to these new therapies due to their unique biomedical mechanisms. As a result, various phase I–II clinical trial designs have been proposed to identify the optimal biological dose that maximizes the therapeutic effect of targeted therapies and immunotherapies by jointly monitoring both efficacy and toxicity outcomes. This review article examines several innovative phase I–II clinical trial designs that utilize accumulated efficacy and toxicity outcomes to adaptively determine doses for subsequent patients and …

Improving School Discipline, Climate, And Culture: Interactive Guidance For Schools And Districts, Gwendolyn Murray

Reports

This interactive guide is designed to support K-12 school districts and schools to proactively improve school environments by supporting teacher development and building systems to promote positive student behaviors. Practices and strategies in the guide can be used to reduce exclusionary discipline and improve school climate and culture. Activities enable users to think critically about school discipline and invest in data-driven and prevention-oriented systems to address students' challenging and problematic behaviors.

Recycling Functional Fillers From Waste Tires For Tailored Polystyrene Composites: Mechanical, Fire Retarding, Electromagnetic Field Shielding, And Acoustic Insulation Properties—A Short Review, Jinlong Zhang, Hang Liu, Shyam S. Sablani, Qinglin Wu

Faculty Publications

Polymer waste is currently a big and challenging issue throughout the world. Waste tires represent an important source of polymer waste. Therefore, it is highly desirable to recycle functional fillers from waste tires to develop composite materials for advanced applications. The primary theme of this review involves an overview of developing polystyrene (PS) composites using materials from recycled tires as fillers; waste tire recycling in terms of ground tire rubbers, carbon black, and textile fibers; surface treatments of the fillers to optimize various composite properties; and the mechanical, fire retarding, acoustic, and electromagnetic field (EMI) shielding performances of PS composite …

Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress …

Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …

Dimensions Of Parenting And Children’S Conduct Problems: The Importance Of Considering Children’S Callous–Unemotional Traits, Carolina Facci, Andrea Baroncelli, Paul J. Frick, Enrica Ciucci

Faculty Publications

Research has clearly indicated that the development of serious behavioral problems in children and adolescents is influenced by parenting. However, recent research has refined the role of parenting by showing the importance of distinguishing between different types of parenting and in considering the role of callous–unemotional traits (CU traits) and conduct problems (CP) of the children. In the current study, we advance this research by distinguishing between emotional (e.g., parental warmth; parental hostility) and behavioral (e.g., use of positive reinforcement; inconsistent discipline/harsh discipline) aspects of parenting and by considering the way parents respond to children’s emotions (i.e., coaching and dismissing). …

Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

No abstract provided.

Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang

Division of Basic Science Faculty Publications

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT …

Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …

Associations Between Daily Step Count Classifications And Continuous Glucose Monitoring Metrics In Adults With Type 1 Diabetes: Analysis Of The Type 1 Diabetes Exercise Initiative (T1dexi) Cohort, Lauren V. Turner, Martin Chase Marak, Robin L. Gal, Peter Calhoun, Zoey Li, Peter G. Jacobs, Mark A. Clements, Corby K. Martin, Francis J. Doyle, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Michael C. Riddell

Clinical Research Faculty Publications

Aims/hypothesis: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. Methods: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups—below (< 7000), meeting (7000–10,000) or exceeding (>10,000) the daily step count goal—to determine if step count category influenced CGM metrics, including per cent time …

Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev

Clinical Research Faculty Publications

Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2-year CR intervention slowed biological aging. Here, we extend these analyses to test effects of CR on telomere length (TL) attrition. TL was quantified in blood samples collected at baseline, 12-, …

Retraction Notice To “A Feasibility Study Of The Combination Of Intranasal Insulin With Dulaglutide For Cognition In Older Adults With Metabolic Syndrome At High Dementia Risk- Study Rationale And Design” [Mech. Ageing Dev. 213 (2023) 111825] (Mechanisms Of Ageing And Development (2023) 213, (S0047637423000519), (10.1016/J.Mad.2023.111825)), Tal Davidy, Iscka Yore, Tali Cukierman-Yaffe, Ramit Ravona-Springer, Abigail Livny, Orit H. Lesman-Segev, Yossi Azuri, Owen Carmichael, Dimitrios Kapogiannis, Henrik Zetterberg, Hung Mo Lin, Mary Sano, Michal Schnaider Beeri

Clinical Research Faculty Publications

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). “This article has been retracted at the request of the authors and Editor-in-Chief. The authors brought to the Editor-in-Chief's attention that they encountered an issue during the ongoing preparations for their research study involving the formulation of the placebo for Dulaglutide. The manuscript described the design and methods of a double-blind placebo controlled clinical trial examining the combined effects of twice daily intranasal insulin and once weekly an injection of dulaglutide. At the time of publication, the authors were awaiting a placebo syringe for dulaglutide to be …

Recovery Of The X-Ray Polarisation Of Swift J1727.8-1613 After The Soft-To-Hard Spectral Transition, J. Podgorný, J. Svoboda, M. Dovčiak, A. Veledina, J. Poutanen, P. Kaaret, S. Bianchi, A. Ingram, F. Capitanio, S. R. Datta, E. Egron, H. Krawczynski, G. Matt, F. Muleri, P. O. Petrucci, T. D. Russell, J. F. Steiner, N. Bollemeijer, M. Brigitte, N. Castro Segura, R. Emami, J. A. García, K. Hu, M. N. Iacolina, V. Kravtsov, L. Marra, G. Mastroserio, T. Muñoz-Darias, E. Nathan, M. Negro, A. Ratheesh, N. Rodriguez Cavero, R. Taverna

Faculty Publications

We report on the detection of X-ray polarisation in the black-hole X-ray binary Swift J1727.8-1613 during its dim hard spectral state by the Imaging X-ray Polarimetry Explorer (IXPE). This is the first detection of X-ray polarisation at the transition from the soft to the hard state in an X-ray binary. We find an averaged 2- 8 keV polarisation degree of (3.3 ± 0.4)% and a corresponding polarisation angle of 3 ±4, which matches the polarisation detected during the rising stage of the outburst, in September- October 2023, within 1σuncertainty. The observational campaign complements previous studies of this source and enables …

Pulsar-Wind-Nebula-Powered Galactic Center X-Ray Filament G0.13- 0.11: Proof Of The Synchrotron Nature By Ixpe, Eugene Churazov, Ildar Khabibullin, Thibault Barnouin, Niccolò Bucciantini, Enrico Costa, Laura Di Gesu, Alessandro Di Marco, Riccardo Ferrazzoli, William Forman, Philip Kaaret, Dawoon E. Kim, Jeffery J. Kolodziejczak, Ralph Kraft, Frédéric Marin, Giorgio Matt, Michela Negro, Roger W. Romani, Stefano Silvestri, Paolo Soffitta, Rashid Sunyaev, Jiri Svoboda, Alexey Vikhlinin, Martin C. Weisskopf, Fei Xie, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino

Faculty Publications

We report the discovery of X-ray polarization from the X-ray-bright filament G0.13-0.11 in the Galactic center (GC) region. This filament features a bright, hard X-ray source that is most plausibly a pulsar wind nebula (PWN) and an extended and structured diffuse component. Combining the polarization signal from IXPE with the imaging/spectroscopic data from Chandra, we find that X-ray emission of G0.13-0.11 is highly polarized PD = 57(±18)% in the 3-6 keV band, while the polarization angle is PA = 21° ± 9). This high degree of polarization proves the synchrotron origin of the X-ray emission from G0.13-0.11. In turn, the …

Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison

Faculty Publications

Black oat (Avena strigosa Schreb.) might be an attractive forage species in the northeastern United States, since it is generally more heat tolerant and disease resistant than other cool-season grasses. Black oat is currently recommended for fall and winter production in USDA Plant Hardiness ones 8b–10a, which is beyond the northeastern United States (Zones 2a–6a). The objective was to evaluate 10 black oat breeding lines (referred to as “UF1” through “UF10”) for forage accumulation, crude protein (CP), neutral detergent fiber (aNDF), acid detergent fiber (ADF), and in vitro digestible organic matter (IVDOM) concentrations. The experiment was carried out in April–July …

Assessing The Long-Term Effects Of Conservation Agriculture On Cotton Production In Northeast Louisiana Using The Denitrification–Decomposition Model, Janntul Ferdush, Changyoon Jeong, Hwangju Jeon, Jim Wang, Kyoung Ro, Xi Zhang, Meesook Lee

Faculty Publications

Conservation agriculture (CA) aims to sustain agricultural production, soil, and environmental health in agroecosystems and has been promoted throughout the United States. The adoption of CA in cotton (Gossypium hirsutum) systems provides both agronomic and environmental benefits. Yet, there is limited information on the long-term effects of CA practices on crop yield and adaptation strategies. An integrated CA system, that is, cover crops with no-tillage (NT) instead of conventional agriculture, was implemented in the long-term field experiments and assessed with an integrated biogeochemical model. Using the denitrification–decomposition model, this study estimated the effects of four different cover crops, for example, …

Correction To: The Impact Of Community Belongingness On Mental Health And Well-Being Among Black Lgbtq Adults (Race And Social Problems, (2024), 16, 1, (47-64), 10.1007/S12552-023-09396-5), Keith J. Watts, Shawndaya S. Thrasher

Faculty Publications

In the original publication of this article, the header “Percent” was misprinted as “%/M (SD)” for Table 1 and it has been corrected as “% M (SD)”. The original article has been corrected.

Targeting Cancers With Ohsv-Based Oncolytic Viral Immunotherapy, Rakin Tammam Nasar, Ifeanyi Kingsley Uche, Konstantin G. Kousoulas

Faculty Publications

The recent success of cancer immunotherapies, such as immune checkpoint inhibitor (ICIs), monoclonal antibodies (mAbs), cancer vaccines, and adoptive cellular therapies (ACTs), has revolutionized traditional cancer treatment. However, these immunotherapeutic modalities have variable efficacies, and many of them exhibit adverse effects. Oncolytic viral Immunotherapy (OViT), whereby viruses are used to directly or indirectly induce anti-cancer immune responses, is emerging as a novel immunotherapy for treating patients with different types of cancer. The herpes simplex virus type-1 (HSV-1) possesses many characteristics that inform its use as an effective OViT agents and remains a leading candidate. Its recent clinical success resulted in …

Gestational Diabetes Mellitus And Postpartum Hypertension: Evidence For A Tight Linkage Toward Women's Cardiovascular Health, Yun Shen, Gang Hu

Population and Public Health Science Faculty Publications

No abstract provided.

Stacked Noise Reduction Auto Encoder–Ocean: A Novel Personalized Recommendation Model Enhanced, Bixi Wang, Wenfeng Zheng, Ruiyang Wang, Siyu Lu, Lirong Yin, Lei Wang, Zhengtong Yin, Xinbing Chen

Faculty Publications

With the continuous development of information technology and the rapid increase in new users of social networking sites, recommendation technology is becoming more and more important. After research, it was found that the behavior of users on social networking sites has a great correlation with their personalities. The five characteristics of the OCEAN personality model can cover all aspects of a user’s personality. In this research, a micro-directional propagation model based on the OCEAN personality model and a Stacked Denoising Auto Encoder (SDAE) was built through the application of deep learning to a collaborative filtering technique. Firstly, the dimension of …

Impact Of Low-Load Resistance Exercise With And Without Blood Flow Restriction On Muscle Strength, Endurance, And Oxidative Capacity: A Pilot Study, Brett H. Davis, James E. Stampley, Joshua Granger, Matthew C. Scott, Timothy D. Allerton, Neil M. Johannsen, Guillaume Spielmann, Brian A. Irving

Clinical Research Faculty Publications

Low-load resistance exercise (LLRE) to failure can increase muscle mass, strength, endurance, and mitochondrial oxidative capacity (OXPHOS). However, the impact of adding blood flow restriction to low-load resistance exercise (LLBFR) when matched for volume on these outcomes is incompletely understood. This pilot study examined the impact of 6 weeks of single-legged LLBFR and volume-matched LLRE on thigh bone-free lean mass, strength, endurance, and mitochondrial OXPHOS. Twenty (12 males and 8 females) untrained young adults (mean ± SD; 21 ± 2 years, 168 ± 11 cm, 68 ± 12 kg) completed 6 weeks of either single-legged LLBFR or volume-matched LLRE. Participants …

Evaluating The Relationship Between Parent-Adolescent Communication, Social Media Use, And Psychological Well-Being In Adolescents, Johannah Smith

LSU Doctoral Dissertations

Adolescents, particularly teenage girls, use social media substantially more than any other age group (Boneva et al., 2006; Gross, 2004; Padilla-Walker et al., 2020). Greater social media use has been linked to internalizing and externalizing problems; however, specific social media behavior and the relation to internalizing and externalizing problems is unknown. Additionally, how parent-adolescent communication impacts the relationships has not been explored. This is concerning as specific social media behavior, such as ruminating with peers and general social media addiction, has been linked to adolescents’ psychological well-being. (Sarmiento et al., 2020; Shensa et al., 2017; Nesi et al., 2020). The …

Modeling And Forecasting Cyanobacterial Harmful Algal Blooms (Cyanohabs) In Lake Pontchartrain, Shekhar Mahat

LSU Master's Theses

Harmful algal blooms (HABs) frequently occur in coastal waters worldwide, adversely affecting economies, human health, aquatic ecosystems, and recreational activities. Lake Pontchartrain, an oligohaline estuary, experienced frequent HABs from 2018 to 2023. While NOAA’s NCCOS and USEPA’s CyAN currently monitor cyanobacteria harmful algal blooms (CyanoHABs) in coastal, freshwater, and riverine systems, there is a notable lack of systems monitoring phycocyanin concentrations in the lake. This thesis utilizes satellite remote sensing environmental stressors to model and predict CyanoHABs in Lake Pontchartrain using machine learning techniques. A key focus of this study is assessing the forecasting capabilities of the random forest method …

Spatial Roost Networks And Resource Selection Of Female Wild Turkeys, Nicholas W. Bakner, Erin E. Ulrey, Patrick H. Wightman, Nick A. Gulotta, Bret A. Collier, Michael J. Chamberlain

Faculty Publications

Wildlife demography is influenced by behavioural decisions, with sleep being a crucial avian behaviour. Avian species use roost sites to minimize thermoregulation costs, predation risk and enhance foraging efficiency. Sleep locations are often reused, forming networks within the home range. Our study, focusing on female eastern wild turkeys (Meleagris gallopavo silvestris) during the reproductive season, used social network analysis to quantify both roost site selection and network structure. We identified roost networks which were composed of a small percentage of hub roost sites connecting satellite roosts. Hub roosts were characterized by greater values of betweenness (β = 0.62, s.e. = …

Hydrometeorological Drivers Of The 2023 Louisiana Water Crisis, P. W. Miller, M. Hiatt

Faculty Publications

During summer and fall 2023, Louisiana experienced a historic local drought while dry conditions elsewhere in the central US withheld vital runoff from the Mississippi River, leading to below-normal discharge into the Gulf of Mexico. Thus, by late October 2023, Louisiana was gripped by two super-imposed water crises: a severe local drought and saltwater contamination in the Mississippi River channel. This study frames the development of the water emergency through the lens of flash drought using the Evaporative Demand Drought Index (EDDI). The EDDI shows south Louisiana experience a flash drought during June 2023, while the Mississippi River basin was …

Top-Down Control Of Ammonia Oxidizers By Grazing In The North Pacific, Silin Ni, Min Nina Xu, Moge Du, Edward A. Laws, Shuh Ji Kao

Faculty Publications

The impact of grazing pressure on ammonia oxidizers (AO) has never been quantified in the field. Here we develop a new method to quantify the grazing rates on AO in aquatic systems. We introduce ¹⁵NH4⁺ tracer into the traditional dilution experiments to measure AO's apparent growth rates by using the end-product of ¹⁵NH4⁺ oxidation, that is, ¹⁵NOx⁻. Field studies in the North Pacific revealed that ¹⁵NOx⁻ in the end-product was sensitive enough to detect AO's grazing rates. Experiments from the lower euphotic zone showed NH4⁺ replete growth rates of 0.40 …

Comparing Editorial And Artificially Generated Fingerings: A Case Study, Lixi Qin

LSU Doctoral Dissertations

Fingering is crucial for piano performance. Unlike other instruments with relatively fixed fingerings, keyboard instruments offer countless fingering combinations. As musical styles have evolved, so too have the instruments themselves, resulting in a rich history of diverse fingering systems, which sometimes conflict with one another. Moreover, due to individual differences in hand shape and size, the fingering advice from editors or teachers may not be universally applicable, and there is a lack of an objective, unified standard for validating these recommendations.

For students who do not fully understand fingering principles and have not been exposed to a wide range of …

Farmer's Adaptive Capacity And Adoption Of Strategies To Climate Change Among Mountain Communities In Nepal, Tanvir Hossain

LSU Master's Theses

Climate change presents significant challenges to agriculture worldwide, particularly where farming is central to livelihoods. This phenomenon has been linked to decreasing crop yields due to rising temperatures and reduced rainfall, particularly affecting low-income countries with limited adaptive capabilities. Grasping how farmers perceive climate change is essential for developing effective adaptation strategies to lessen its adverse impacts. This study concentrated on investigating the perceptions and adaptive strategies employed by smallholder farmers in Nepal's Mustang district, utilizing primary data sources. Data from 131 randomly selected households were gathered through structured interviews, while focus group discussions provided qualitative insights into farmers' views …