Digital Commons Network^™

An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari

Faculty Publications

Vaccine hesitancy is a public health threat stoked by vaccine skeptical rhetorics that circulate via the Web. While there is a body of work that studies the digital rhetorical tactics of vaccine skeptics, most of this work focuses on the Web rhetorics of the “Web 2.0” era, leaving the “Web 1.0” era relatively understudied and, in turn, foreclosing opportunities to look back before moving forward in the current moment. In efforts to yield glimpses into the antecedents of digital culture that have shaped contemporary vaccine skeptical discourses, in this article, we draw on systematically sourced website “snapshots” of vaccine skeptical …

Resilience And Resourcefulness: How Crisis Centers In Louisiana Adapted Services During Covid-19, Fanny Ramirez, Ashlyn Barclay, Rockia Harris

Faculty Publications

Purpose: This article examines how crisis centers in Louisiana, USA, adapted their direct care services during COVID-19 to continue helping survivors affected by violence. Organizational resilience theory serves as the project’s main theoretical framework. As such, we report on how community- and university-based crisis centers drew on principles of resilience and resourcefulness to adapt their direct care services (e.g., crafting normalcy, putting alternative logics to work) during this difficult time. Method: We draw on 21 in-depth interviews with upper-level administrators from organizations working in violence against women conducted during the summer of 2020. The interview transcripts yielded 184 single-spaced pages …

Conversations With Rick Veitch, Brannon Costello

LSU Faculty-Published Books

From his roots in underground comics to his high-profile runs on mainstream characters, Rick Veitch (b. 1951) has carved out a career unlike anyone else’s. Collecting thirteen interviews—including three published here for the first time—Conversations with Rick Veitch offers a wealth of insight not only into the development of Veitch’s graphic innovations and metaphysical explorations, but also into the upheavals and transformations of American comics from the 1970s to today. In acclaimed comics such as The Maximortal, Army@Love, and Can’t Get No, Veitch employs a style that synthesizes Jack Kirby at his most cosmic, the mind-bending graphic sensibility of European …

Rheological Characterization And Printability Of Sodium Alginate–Gelatin Hydrogel For 3d Cultures And Bioprinting, Mohan Kumar Dey, Ram V. Devireddy

Faculty Publications

The development of biocompatible hydrogels for 3D bioprinting is essential for creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, and biocompatibility of a novel Alg-Gel hydrogel blend (alginate and gelatin) for use in extrusion-based 3D bioprinting. A range of hydrogel compositions were evaluated for their rheological behavior, including shear-thinning properties, storage modulus, and compressive modulus, which are crucial for maintaining structural integrity during printing and supporting cell viability. The printability assessment of the 7% alginate–8% gelatin hydrogel demonstrated that the 27T tapered needle achieved the highest normalized Printability Index (POInormalized = …

A Network Analysis Of Social Determinants Of Health And Youth Suicidal Ideation And Suicide Attempts At The Neighborhood-Level In Houston, Tx, Tyler Hendley

LSU Master's Theses

Youth suicide is a complex, multi-faceted human phenomenon that has no singular cause but instead is theorized to be a result of an interplay of psychological, biological, and social risk and protective factors. To best identify youth suicide risk and possible avenues for intervention, a social-ecological model approach may prove beneficial. As community-level risk factors (i.e., social determinants of health (SDOH)) have shown to impact health outcomes, it is important to understand the association between community-level risk and youth suicide-related behaviors. Utilizing a network analytic approach, this study developed an estimated partial correlation network to understand the relationship between youth …

Co2 In Flowing Freshwaters: Macro Scale Database Compilation, Addressing Ph Bias In Co2 Estimates, And Quantifying Cross-Scale Interactions, Timothy R. Toavs

LSU Doctoral Dissertations

This dissertation focuses on carbon dioxide (CO₂) dynamics in flowing freshwaters, contributing to the growing body of knowledge about inland water carbon cycles. The research is structured into three main chapters, each progressing towards the objective of utilizing variability in flowing freshwaters to further understand carbon dynamics, anthropogenic land cover impacts, and potential impacts from a changing climate. Chapter one compiles a 30-year dataset of pCO₂ measurements from flowing freshwater systems across the contiguous United States. This dataset, referred to as CDFLOW, includes over 750,000 pCO₂ estimates from more than 35,000 locations. It serves …

Nipping Crime In The Bud: The Spatial Relationship Between Crime And Meeting People’S Needs, Alicia Cerquone

LSU Master's Theses

The recent high-profile killings of people by the police brought attention to police violence, and prompted activists to call for an end to police violence. Drawing from an understanding of strain theory (Merton, 1938; Farnworth & Leiber, 1989; Agnew, 1992; Agnew, 2001; Agnew, 2008) and Tucker and Cadora’s (2003) ideas of justice reinvestment, this research was designed with the belief that police funding can be better used to help people meet their basic needs of housing, healthcare, and education. This research is concerned with the spatial relationship between crime and the quality of social infrastructure, or the programs in place …

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …

Charging, Aggregation, And Electrostatic Dispersion Of Radioactive And Nonradioactive Particles In The Atmosphere, Yong Ha Kim, Sotira Yiacoumi, Costas Tsouris

Faculty Publications

Electrostatic dispersion can significantly impact the microphysical behavior of charged particles and ions until reaching zero space charge. However, although radioactive particles can be strongly charged in air, the influence of electrostatic dispersion has been neglected in understanding their behavior. This study is aimed at investigating the time evolution of the charge and size distributions of radioactive and nonradioactive particles in air and developing simple approaches for applications. With processes involving charging, aggregation, and electrostatic dispersion, a comprehensive population balance model (PBM) has been developed to examine particle charge/size distribution dynamics. It is shown that compared to nonradioactive particles, the …

Biological Control Of Roseau Cane Scale With Parasitoid Wasps In Louisiana, Tanner C. Sparks

LSU Doctoral Dissertations

Roseau cane scale, Nipponaclerda biwakoensis (Hemiptera: Aclerdidae) is an invasive species of scale insect negatively impacting Phragmites australis (Cyperales: Poaceae) stands within the Mississippi River Delta. The scales were first detected in 2017 from reports of Phragmites die-back within the MRD by landowners. Initial range surveys located RCS infested Phragmites stands were primarily limited to southeastern Louisiana with a single population near Port Arthur, Texas. Follow-up field surveys conducted annually from 2021 to 2023 monitoring further range expansion by the scale show the current range extends nearly 600 km between High Island, Texas and Bayou la Batre, Alabama. Climate matching …

Screen Media, Obesity, And Nutrition, Amanda E. Staiano, Alyssa M. Button, Gary S. Goldfield, Thomas N. Robinson, Jorge Mota, Susan J. Woolford, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

This chapter provides an update on and the synthesis of the most current evidence on screen use, nutritional intake, and obesity in youth. The strongest evidence of a mechanism linking screen media use to obesity is through repeated exposures to unhealthy food marketing and excess eating while viewing screens. Evidence of the neurocognitive effects on dietary consumption via the effects of executive function, satiety, and memory is emerging. Interventions to reduce children's screen time or to incorporate screen media into improving nutrition and obesity outcomes have had mixed results. The evidence base is also limited by imprecise measurements of screen …

Digital Screen Media Use, Movement Behaviors, And Child Health, Mark S. Tremblay, Nicholas Kuzik, Stuart J.H. Biddle, Valerie Carson, Mai J.M. Chinapaw, Dorothea Dumuid, Wendy Yajun Huang, Travis J. Saunders, Amanda E. Staiano, Russell R. Pate

Population and Public Health Science Faculty Publications

This chapter summarizes the associations between children's digital screen media use (DSMU) and their health, within the 24-h movement behavior framework (physical activities, sedentary behaviors, sleep), provides recommendations for healthy DSMU, and highlights future research directions. Key concepts include behavior displacement, combined associations, and DSMU context and content. Displacement examples include more DSMU decreasing time for healthier behaviors (e.g., physical activity or sleep) or replacing reading books and magazines with DSMU alternatives (e.g., texting, social media). How DSMU affects the relationships between various combinations of movement behaviors and children's health is largely unknown. Total DSMU is most frequently studied, but …

Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune

Faculty Publications

Coastal wetlands are one of the most productive ecosystems on Earth with the capacity to sequester large amounts of carbon dioxide (CO2). Wetland loss due to anthropogenic and natural causes reduces the carbon (C) storage capacity and potentially releases previously fixed C in biomass and soil to the water column and atmosphere through decomposition. Coastal wetland restoration has the potential to mitigate some of the C losses depending on the balance of C fluxes. However, the role of vegetation and environmental conditions in governing rates of C accumulation in restoration sites is not well resolved. The purpose of this study …

Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo

Faculty Publications

Although mangroves provide many beneficial ecosystem services, such as blue carbon storage and coastal protection, they are currently under threat due to changes in climate conditions, such as prolonged drought exposure. Under drought conditions, evaporation exceeds precipitation and high soil salinities can lead to stunted growth and die-back. To quantify this interplay, we developed a database for low-lying and uninhabited mangrove islands in the Caribbean under various evaporation and precipitation regimes. We extracted physical and biological information from each island using remote sensing techniques and coupled it with a process-based model. We used this database to develop a model that …

Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy

Faculty Publications

There is an urgent need for models that can robustly detect past and project future ecosystem changes and risks to the services that they provide to people. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) was established to develop model ensembles for projecting long-term impacts of climate change on fisheries and marine ecosystems while informing policy at spatio-temporal scales relevant to the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) framework. While contributing FishMIP models have improved over time, large uncertainties in projections remain, particularly in coastal and shelf seas where most of the world's fisheries occur. Furthermore, previous FishMIP climate …

Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway

Clinical Research Faculty Publications

Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as first-line treatments for T2D based on significant weight loss results. The composition of weight loss using most diets consists of < 25% fat-free mass (FFM) loss, with the remainder from fat stores. Higher amounts of weight loss (achieved with metabolic bariatric surgery) result in greater reductions in FFM. Our aim was to assess the impact that GLP-1RA-based treatments have on FFM. We analysed studies that reported changes in FFM with the following agents: exenatide, liraglutide, semaglutide, and the dual incretin receptor agonist tirzepatide. We performed an analysis of various weight loss interventions to provide a reference for expected changes in FFM. We evaluated studies using dual-energy X-ray absorptiometry (DXA) for measuring FFM (a crude surrogate for skeletal muscle). In evaluating the composition of weight loss, the percentage lost as fat-free mass (%FFML) was equal to ΔFFM/total weight change. The %FFML using GLP-1RA-based agents was between 20% and 40%. In the 28 clinical trials evaluated, the proportion of FFM loss was highly variable, but the majority reported %FFML exceeding 25%. Our review was limited to small substudies and the use of DXA, which does not measure skeletal muscle mass directly. Since FFM contains a variable amount of muscle (approximately 55%), this indirect measure may explain the heterogeneity in the data. Assessing quantity and quality of skeletal muscle using advanced imaging (magnetic resonance imaging) with functional testing will help fill the gaps in our current understanding.

The Role Of Government Assistance, Housing, And Employment On Postpartum Maternal Health Across Income And Race: A Mixed Methods Study, Chelsea L. Kracht, Kelsey O. Goynes, Madison Dickey, Briasha Jones, Emerson Simeon, Jada Butler, Maryam Kebbe, Kaja Falkenhain, Emily W. Harville, Elizabeth F. Sutton, Leanne M. Redman

Clinical Research Faculty Publications

Background: Stressful large-scale events, such as the COVID-19 pandemic and natural disasters, impact birthing individuals’ postpartum experiences and their mental health. Resultant changes in government assistance, housing, and employment may further exacerbate these impacts, with differences experienced by varying income levels and races. This study aimed to examine maternal depression and anxiety in postpartum individuals by income and race during a stressful large-scale event, and the mediating role of government assistance, housing, and employment. Methods: An explanatory sequential mixed methods study was conducted (QUANT + QUAL). For aim 1 (quantitative), birthing individuals who delivered during peak pandemic (June 2020 - …

Precision Prognostics For Cardiovascular Disease In Type 2 Diabetes: A Systematic Review And Meta-Analysis, Abrar Ahmad, Lee Ling Lim, Mario Luca Morieri, Claudia Ha Ting Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. De Souza, Russell J. De Souza, Deirdre Kay Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo

Clinical Research Faculty Publications

Background: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcomes were reported for 321 biomarker studies, 48 genetic marker studies, and 47 risk score/model studies. Results: Out of all evaluated biomarkers, only 13 showed improvement in prediction performance. Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of …

A Systematic Umbrella Review And Meta-Meta-Analysis Of Ehealth And Mhealth Interventions For Improving Lifestyle Behaviours, Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren Von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher

Population and Public Health Science Faculty Publications

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, sedentary behaviour, healthy eating and sleep. Nine electronic databases were searched for eligible studies published from inception to 1 June 2023. Systematic reviews with meta-analyses of RCTs that evaluate e- and m-Health interventions designed to improve physical activity, sedentary behaviour, sleep and healthy eating in any adult population were included. Forty-seven meta-analyses were included, comprising of 507 RCTs and 206,873 participants. Interventions involved mobile apps, web-based and SMS interventions, with 14 focused on …

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …

Vegetation Dieback In The Mississippi River Delta Triggered By Acute Drought And Chronic Relative Sea-Level Rise, Tracy Elsey-Quirk, Austin Lynn, Michael Derek Jacobs, Rodrigo Diaz, James T. Cronin, Lixia Wang, Haosheng Huang, Dubravko Justic

Faculty Publications

Coastal wetlands are vulnerable to sea-level rise. Here, the authors use 16 years of data to correlate vegetation dieback in the Mississippi River Delta to drought-induced salt water intrusion in the summer of 2012.

Covid, Elite Rhetoric, And Americans’ Attitudes Toward U.S. Trade Practices With China, Dmitriy Nurullayev, Ping Xu, James Garand

Faculty Publications

Objectives: In this article, we consider how the COVID-19 pandemic and evaluations of Donald Trump combined to influence Americans' attitudes toward U.S. trade practices with China. We suggest that psychological factors—such as confirmation bias and transfer of grievances—influence how individuals evaluate the costs and benefits of trade. Specifically, we argue that the severity of the pandemic (reflected by both cumulative deaths and news coverage of the pandemic) and the rhetoric of (then) President Trump came together to influence Americans’ attitudes toward trade with China. Methods: To assess the COVID effect, the Trump effect, and their interaction effect on trade opinion, …

Reply To Myers And Rosser: A Comment About Studying The Health Effects Of Smoke Produced By Prescribed Fire, Dwan Vilcins, Wen R. Lee, Tamara L. Blake, Wenbo Wu, Stephania Cormier, Peter D. Sly

Division of Basic Science Faculty Publications

No abstract provided.

Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the Supplementary information section in the online version of the article. Citations to Supplementary Data 3 in the article remain unchanged.

Early Life Energy Balance: The Development Of Infant Energy Expenditure And Intake In The Context Of Obesity, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: This review aims to provide a summary of the current knowledge on measurement tools and most recent evidence for prenatal and postnatal modulators of energy balance in young infants. Recent Findings: The prevention of pediatric obesity depends upon curating the perfect imbalance of energy intake to energy expenditure, taking into consideration the energy needs for healthy growth. We summarize the recent evidence for the programming of fetal and infant metabolism influenced by maternal preconception health, prenatal metabolic milieu, and physical activity behaviors. In the early postnatal environment, caregiver feeding behaviors shape the extent of energy imbalance through …

Precision Treatment Of Beta-Cell Monogenic Diabetes: A Systematic Review, Rochelle N. Naylor, Kashyap A. Patel, Jarno L.T. Kettunen, Jonna M.E. Männistö, Julie Støy, Julie Støy, Jacques Beltrand, Michel Polak, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Beta-cell monogenic forms of diabetes have strong support for precision medicine. We systematically analyzed evidence for precision treatments for GCK-related hyperglycemia, HNF1A-, HNF4A- and HNF1B-diabetes, and mitochondrial diabetes (MD) due to m.3243 A > G variant, 6q24-transient neonatal diabetes mellitus (TND) and SLC19A2-diabetes. Methods: The search of PubMed, MEDLINE, and Embase for individual and group level data for glycemic outcomes using inclusion (English, original articles written after 1992) and exclusion (VUS, multiple diabetes types, absent/aggregated treatment effect measures) criteria. The risk of bias was assessed using NHLBI study-quality assessment tools. Data extracted from Covidence were summarized and presented as descriptive …

Effective Interventions In Preventing Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, Wubet Worku Takele, Kimberly K. Vesco, Jami Josefson, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar G. Mekonnen, Eskedar G. Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR) framework was used to examine intervention characteristics (who, what, when, where, and how). Subgroup analysis was performed by intervention characteristics. Results: 116 studies involving 40,940 participants are included. Group-based physical activity interventions (RR 0.66; 95% CI 0.46, 0.95) reduce the incidence of GDM compared with individual or mixed (individual and group) …

Islet Autoantibodies As Precision Diagnostic Tools To Characterize Heterogeneity In Type 1 Diabetes: A Systematic Review, Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Kurt J. Griffin, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr

Clinical Research Faculty Publications

Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Results: …

Precision Stratification Of Prognostic Risk Factors Associated With Outcomes In Gestational Diabetes Mellitus: A Systematic Review, Zhila Semnani-Azad, Romy Gaillard, Alice E. Hughes, Kristen E. Boyle, Kristen E. Boyle, Deirdre K. Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu

Clinical Research Faculty Publications

Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through September 30th, 2021, that focused on the above outcomes of interest with respect to sociodemographic factors, lifestyle and behavioral characteristics, traditional clinical traits, and ‘omics biomarkers in the mothers and offspring during the perinatal/postpartum periods and across the lifecourse. Studies that did not report …

Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg

Faculty Publications

Antisocial and illegal behavior generally declines as youth approach adulthood, but there is significant individual variation in the timing of the peak and decline of offending from adolescence to young adulthood. There are two primary research questions in the present study. First, are there subgroups of youth who follow similar patterns of offending over the nine years after their first arrest? Second, what baseline factors predict which youth will follow each pattern of offending? Data were drawn from the Crossroads study, which includes a sample of racially and ethnically diverse boys who were interviewed regularly for 9 years following their …