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Louisiana State University

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Articles 1981 - 2010 of 21705

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Association Of Lipid Profile Biomarkers With Breast Cancer By Molecular Subtype: Analysis Of The Mend Study, Anjali Gupta, Veeral Saraiya, April Deveaux, Taofik Oyekunle, Klarissa D. Jackson, Omolola Salako, Adetola Daramola, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Michael J. Muehlbauer, Christopher B. Newgard, Samuel Ajayi, Yemi Raji, Timothy Olanrewaju, Charlotte Osafo, Ifeoma Ulasi, Adanze Asinobi, Cheryl A. Winkler, David Burke, Fatiu Arogundade, Ivy Ekem Dec 2022

Association Of Lipid Profile Biomarkers With Breast Cancer By Molecular Subtype: Analysis Of The Mend Study, Anjali Gupta, Veeral Saraiya, April Deveaux, Taofik Oyekunle, Klarissa D. Jackson, Omolola Salako, Adetola Daramola, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Michael J. Muehlbauer, Christopher B. Newgard, Samuel Ajayi, Yemi Raji, Timothy Olanrewaju, Charlotte Osafo, Ifeoma Ulasi, Adanze Asinobi, Cheryl A. Winkler, David Burke, Fatiu Arogundade, Ivy Ekem

Faculty Publications

There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted …

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Ecry1gb.1ig, A Novel Chimeric Cry Protein With High Efficacy Against Multiple Fall Armyworm (Spodoptera Frugiperda) Strains Resistant To Different Gm Traits, Hyunsook Chae, Zhimou Wen, Travis Hootman, Jo Himes, Qianqian Duan, Joel Mcmath, Jesse Ditillo, Richard Sessler, Jared Conville, Ying Niu, Phillip Matthews, Fabricio Francischini, Fangneng Huang, Matthew Bramlett Dec 2022

Ecry1gb.1ig, A Novel Chimeric Cry Protein With High Efficacy Against Multiple Fall Armyworm (Spodoptera Frugiperda) Strains Resistant To Different Gm Traits, Hyunsook Chae, Zhimou Wen, Travis Hootman, Jo Himes, Qianqian Duan, Joel Mcmath, Jesse Ditillo, Richard Sessler, Jared Conville, Ying Niu, Phillip Matthews, Fabricio Francischini, Fangneng Huang, Matthew Bramlett

Faculty Publications

Spodoptera frugiperda (fall armyworm, FAW) is one of the most devastating insect pests to corn and soybean production in the Americas and is rapidly expanding its range worldwide. It is known to be hard to control either by chemical insecticide applications or by GM. Although the use of GM traits can be an effective way to control this pest, it is very rare to find native insecticidal proteins that provide the necessary level of FAW control in crop fields where FAW pressure and damage are high. Insecticidal Cry proteins sourced from Bacillus thuringiensis have been heavily utilized in the development …

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Politics & Marriage: The Generational Gap In Marriage Priorities And Political Ambition Among Black Women In Politics, Torri A. Jackson Dec 2022

Politics & Marriage: The Generational Gap In Marriage Priorities And Political Ambition Among Black Women In Politics, Torri A. Jackson

Honors Capstones

No abstract provided.

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Leadership Development And Training In Community-Based Organizations In Myanmar, Anna Rockett Dec 2022

Leadership Development And Training In Community-Based Organizations In Myanmar, Anna Rockett

Honors Capstones

No abstract provided.

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Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes Dec 2022

Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes

Reports

Child abuse and neglect is a leading factor in the staggeringly high rates of child mortality in Louisiana. In 2017, Louisiana had 44,793 total referrals for child abuse and neglect of which 19,851 were investigated (CWLA, 2019). Child abuse and neglect can have multiple detrimental effects on a child’s physical, psychological, and behavioral health. Effective prevention efforts are critical to ensuring the immediate and long-term safety and well-being of children in Louisiana. Each year, LCTF selects high-quality proposals and funds a range of prevention efforts to protect children, strengthen family well-being, and educate the public about children’s safety. Local, national, …

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Spatial And Temporal Changes Of Sand Mining In The Yangtze River Basin Since The Establishment Of The Three Gorges Dam, Yugai Ma, Yingying Chai, Y. Jun Xu, Zijun Li, Shuwei Zheng Dec 2022

Spatial And Temporal Changes Of Sand Mining In The Yangtze River Basin Since The Establishment Of The Three Gorges Dam, Yugai Ma, Yingying Chai, Y. Jun Xu, Zijun Li, Shuwei Zheng

Faculty Publications

The global demand for sand and gravel is at 50 billion tons per year, far exceeding global resource capacities. It reached 7.6 billion tons in 2021 in the Yangtze River Basin (YRB), China. However, production is severely limited in the YRB. Therefore, the incongruity between the supply and demand of river sand is prominent. Wise management of decreasing sand resources in the YRB has become critical since the Three Gorges Dam became operational in 2003. This study synthesized spatial and temporal changes in sand mining activities and quantities along the Yangtze River and its major tributaries from 2004 to 2020. …

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Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd Dec 2022

Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Background: Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared to 90% for well-differentiated liposarcoma (WDLPS). This discrepancy may be connected to their potential to form adipocytes, where WDLPS is adipogenic but DDLPS is adipogenic-impaired. Normal adipogenesis requires Zinc Finger Protein 423 (ZFP423), a transcriptional coregulator of Perixosome Proliferator Activated Receptor gamma (PPARG2) mRNA expression that defines committed preadipocytes. Expression of ZFP423 in preadipocytes is promoted by Seven-In-Absentia Homolog …

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Sk3 In Pomc Neurons Plays A Sexually Dimorphic Role In Energy And Glucose Homeostasis, Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang Dec 2022

Sk3 In Pomc Neurons Plays A Sexually Dimorphic Role In Energy And Glucose Homeostasis, Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang

Division of Basic Science Faculty Publications

Background: Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood. Results: We detected small conductance calcium-activated potassium (SK) current in POMC neurons. Secondary analysis of published single-cell RNA-Seq data showed that POMC neurons abundantly express SK3, one SK channel subunit. To test whether SK3 in POMC neurons regulates POMC neuron functions on energy and glucose homeostasis, we used a Cre-loxP strategy to delete SK3 specifically from mature POMC neurons. POMC-specific deletion of SK3 did not affect body weight in either …

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Covid-19 Vaccination Boosts The Potency And Breadth Of The Immune Response Against Sars-Cov-2 Among Recovered Patients In Wuhan, Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qiu, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xinguo Li, Zejun Wang, Yong Zhang, Hang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang Dec 2022

Covid-19 Vaccination Boosts The Potency And Breadth Of The Immune Response Against Sars-Cov-2 Among Recovered Patients In Wuhan, Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qiu, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xinguo Li, Zejun Wang, Yong Zhang, Hang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang

Division of Basic Science Faculty Publications

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited …

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Fgf21 Is Required For Protein Restriction To Extend Lifespan And Improve Metabolic Health In Male Mice, Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. Mcdougal, Hans Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison Dec 2022

Fgf21 Is Required For Protein Restriction To Extend Lifespan And Improve Metabolic Health In Male Mice, Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. Mcdougal, Hans Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison

Division of Basic Science Faculty Publications

Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that the hormone FGF21 mediates the metabolic effects of protein restriction in young mice. Here we demonstrate that protein restriction increases lifespan, reduces frailty, lowers body weight and adiposity, improves physical performance, improves glucose tolerance, and alters various metabolic markers within the serum, liver, and adipose tissue of wildtype male mice. Conversely, mice lacking FGF21 fail to exhibit metabolic responses to protein restriction in early life, and in later life exhibit …

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Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin Dec 2022

Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin

Division of Basic Science Faculty Publications

Background: Patient-centred care is an important part of quality healthcare and patient satisfaction has been shown to be associated with improved clinical outcomes. We aim to explore the satisfaction of patients with diabetic kidney disease (DKD) with their visits to the TCM physician and its association with patients' socio-economic characteristics. Methods: A questionnaire survey was conducted among patients aged >21 years with DKD. Participants' demographic, socioeconomic characteristics and satisfaction scores measured with the self-administered Medical Interview Satisfaction Scale (MISS) were collected after they visited the TCM physician. MISS is a 26-item questionnaire consisting of three domains – cognitive, affective and …

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Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple Dec 2022

Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple

Faculty Publications

Geolocators are small devices that record and store time-stamped light levels that researchers typically use to approximate the latitude and longitude of small birds across the annual cycle. However, when geolocators are affixed to leg bands of larger-bodied birds, nest incubation by females interrupts the daily pattern of light and darkness. Thus, geolocators can provide information on nesting propensity, nest success, and renesting intensity; these demographic parameters are both difficult to measure unobtrusively and are critically important in determining population dynamics of birds, especially ducks. Here, we deployed 240 geolocators on mottled ducks Anas fulvigula in Louisiana and Texas in …

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Interindividual Differences In Trainability And Moderators Of Cardiorespiratory Fitness, Waist Circumference, And Body Mass Responses: A Large-Scale Individual Participant Data Meta-Analysis, Jacob T. Bonafiglia, Paul A. Swinton, Robert Ross, Neil M. Johannsen, Corby K. Martin, Timothy S. Church, Cris A. Slentz, Leanna M. Ross, William E. Kraus, Jeremy J. Walsh, Glen P. Kenny, Gary S. Goldfield, Denis Prud’Homme, Ronald J. Sigal, Conrad P. Earnest, Brendon J. Gurd Dec 2022

Interindividual Differences In Trainability And Moderators Of Cardiorespiratory Fitness, Waist Circumference, And Body Mass Responses: A Large-Scale Individual Participant Data Meta-Analysis, Jacob T. Bonafiglia, Paul A. Swinton, Robert Ross, Neil M. Johannsen, Corby K. Martin, Timothy S. Church, Cris A. Slentz, Leanna M. Ross, William E. Kraus, Jeremy J. Walsh, Glen P. Kenny, Gary S. Goldfield, Denis Prud’Homme, Ronald J. Sigal, Conrad P. Earnest, Brendon J. Gurd

Clinical Research Faculty Publications

Although many studies have assumed variability reflects variance caused by exercise training, few studies have examined whether interindividual differences in trainability are present following exercise training. The present individual participant data (IPD) meta-analysis sought to: (1) investigate the presence of interindividual differences in trainability for cardiorespiratory fitness (CRF), waist circumference, and body mass; and (2) examine the influence of exercise training and potential moderators on the probability that an individual will experience clinically important differences. The IPD meta-analysis combined data from 1879 participants from eight previously published randomized controlled trials. We implemented a Bayesian framework to: (1) test the hypothesis …

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Association Between Weight Loss, Change In Physical Activity, And Change In Quality Of Life Following A Corporately Sponsored, Online Weight Loss Program, Christoph Höchsmann, James L. Dorling, Corby K. Martin, Conrad P. Earnest, Timothy S. Church Dec 2022

Association Between Weight Loss, Change In Physical Activity, And Change In Quality Of Life Following A Corporately Sponsored, Online Weight Loss Program, Christoph Höchsmann, James L. Dorling, Corby K. Martin, Conrad P. Earnest, Timothy S. Church

Clinical Research Faculty Publications

Background: The physiological benefits associated with corporately sponsored weight loss programs are increasingly well documented. However, less is known about how these programs affect employees’ quality of life (QoL). The purpose of the present analysis was to examine the association between weight loss, change in physical activity, and change in QoL following a corporately sponsored, online weight loss program. Methods: We examined the relationship between weight loss, self-reported change in physical activity, and change in several QoL indices in 26,658 participants (79% women) after the initial 10 weeks of the online weight loss program. The trend in changes in each …

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Social Inequalities In Climate Change-Attributed Impacts Of Hurricane Harvey, Kevin T. Smiley, Ilan Noy, Michael F. Wehner, Dave Frame, Christopher C. Sampson, Oliver E.J. Wing Dec 2022

Social Inequalities In Climate Change-Attributed Impacts Of Hurricane Harvey, Kevin T. Smiley, Ilan Noy, Michael F. Wehner, Dave Frame, Christopher C. Sampson, Oliver E.J. Wing

Faculty Publications

Climate change is already increasing the severity of extreme weather events such as with rainfall during hurricanes. But little research to date investigates if, and to what extent, there are social inequalities in climate change-attributed extreme weather event impacts. Here, we use climate change attribution science paired with hydrological flood models to estimate climate change-attributed flood depths and damages during Hurricane Harvey in Harris County, Texas. Using detailed land-parcel and census tract socio-economic data, we then describe the socio-spatial characteristics associated with these climate change-induced impacts. We show that 30 to 50% of the flooded properties would not have flooded …

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Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni Dec 2022

Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni

Clinical Research Faculty Publications

Background: To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline. Methods: This is …

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Salivary Immunity Of Elite Collegiate American Football Players Infected With Sars-Cov-2 Normalizes Following Isolation, Joshua Granger, Eunhan Cho, Kevin Lindsey, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O’Neal, Brian A. Irving, Neil Johannsen, Guillaume Spielmann Dec 2022

Salivary Immunity Of Elite Collegiate American Football Players Infected With Sars-Cov-2 Normalizes Following Isolation, Joshua Granger, Eunhan Cho, Kevin Lindsey, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O’Neal, Brian A. Irving, Neil Johannsen, Guillaume Spielmann

Clinical Research Faculty Publications

The impact of COVID-19 on systemic immunity in the general population has been well characterized, however the short-term effects of COVID-19 infection on innate salivary immunity in elite-level athletes are unknown. Therefore, this study aimed to determine whether elite college football athletes had altered salivary immunity following the CDC-recommended isolation post-SARS-CoV-2 infection. Salivary samples were obtained from fourteen elite football players who tested positive for SARS-CoV-2 (n = 14), immediately after CDC-recommended isolation (average days = 14 ± 2 days) and fifteen controls who remained uninfected with SARS-CoV-2. Biomarkers of innate salivary immunity (sIgA and alpha-amylase), antimicrobial proteins (AMPs, i.e., …

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The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith Dec 2022

The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith

Population and Public Health Science Faculty Publications

Background: The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that aligns with the recommendations – assessed via the 2018 WCRF/AICR Score – was associated with lower risk of type 2 diabetes in high-risk adults participating in the Diabetes Prevention Program Outcomes Study (DPPOS). Methods: The Diabetes Prevention Program (DPP) randomized adults at high risk for diabetes to receive a lifestyle intervention (ILS), metformin (MET) or a placebo (PLB) (mean: 3.2 years), with …

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Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia Dec 2022

Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia

Population and Public Health Science Faculty Publications

Purpose This study aimed to describe longitudinal trends in children's moderate-to-vigorous physical activity (MVPA) and to investigate associations with individual, familial, and school characteristics. Methods A sample of 341 Portuguese children age 5-10 yr (173 girls) from six age cohorts was followed over 3 yr using a mixed-longitudinal design. Physical activity, body mass index (BMI), gross motor coordination, and musculoskeletal fitness were assessed annually. Information on socioeconomic status and school characteristics was collected and analyzed with mixed models. Results MVPA shows a similar declining trend in both sexes, but on average, boys exceeded the World Health Organization recommendations of 60 …

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A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis Dec 2022

A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis

Population and Public Health Science Faculty Publications

Abstract: Background: In 2018, the Australian Government updated the Australian Physical Activity and Sedentary Behaviour Guidelines for Children and Young People. A requirement of this update was the incorporation of a 24-hour approach to movement, recognising the importance of adequate sleep. The purpose of this paper was to describe how the updated Australian 24-Hour Movement Guidelines for Children and Young People (5 to 17 years): an integration of physical activity, sedentary behaviour and sleep were developed and the outcomes from this process. Methods: The GRADE-ADOLOPMENT approach was used to develop the guidelines. A Leadership Group was formed, who identified existing …

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Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas Dec 2022

Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas

Clinical Research Faculty Publications

Background: When a lifestyle intervention combines caloric restriction and increased physical activity energy expenditure (PAEE), there are two components of energy balance, energy intake (EI) and physical activity energy expenditure (PAEE), that are routinely misreported and expensive to measure. Energy balance models have successfully predicted EI if PAEE is known. Estimating EI from an energy balance model when PAEE is not known remains an open question. Objective: The objective was to evaluate the performance of an energy balance differential equation model to predict EI in an intervention that includes both calorie restriction and increases in PAEE. Design: The Antonetti energy …

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Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier Dec 2022

Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the …

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The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward Dec 2022

The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and …

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Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2022

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …

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Characterization Of A Stress-Enhanced Promoter From The Grass Halophyte, Spartina Alterniflora L., Sonali Sengupta, Necla Pehlivan, Venkata Mangu, Kanniah Rajasekaran, Niranjan Baisakh Dec 2022

Characterization Of A Stress-Enhanced Promoter From The Grass Halophyte, Spartina Alterniflora L., Sonali Sengupta, Necla Pehlivan, Venkata Mangu, Kanniah Rajasekaran, Niranjan Baisakh

Faculty Publications

Stress-inducible promoters are vital for the desirable expression of genes, especially transcription factors, which could otherwise compromise growth and development when constitutively overexpressed in plants. Here, we report on the characterization of the promoter region of a stress-responsive gene SaAsr1 from monocot halophyte cordgrass (Spartina alterniflora). Several cis-acting elements, such as ABRE (ABA-responsive element), DRE-CRT (dehydration responsive-element/C-Repeat), LTRE (low temperature-responsive element), ERE (ethylene-responsive element), LRE (light-responsive element), etc. contributed at varying degrees to salt-, drought- and ABA-enhanced expression of gusA reporter gene in Arabidopsis thaliana under the full-length promoter, pAsr11875 and its deletion derivatives with an assortment of cis-regulatory motifs. …

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Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle Dec 2022

Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle

Faculty Publications

Improving Customer Satisfaction (CS) is a key strategical goal for companies, especially for Small and Medium-Sized Enterprises (SMEs). The objective of this research is to find and rank the major factors supporting CS. We focus on SMEs in two emerging markets located in two countries with different geographical and supply chain environments. We test a conceptual framework that includes several factors supporting CS. The data were collected from Hungarian and Indonesian SMEs by online questionnaire. We used statistical analysis such as Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Model (SEM) to test our model and hypothesis. …

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Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel Dec 2022

Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel

Faculty Publications

No abstract provided.

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Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson Dec 2022

Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson

Faculty Publications

No abstract provided.

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Greater Evolutionary Divergence Of Thermal Limits Within Marine Than Terrestrial Species, Matthew Sasaki, Jordanna M. Barley, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Morgan W. Kelly, Alysha B. Putnam, Seema N. Sheth, Andrew R. Villeneuve, Brian S. Cheng Dec 2022

Greater Evolutionary Divergence Of Thermal Limits Within Marine Than Terrestrial Species, Matthew Sasaki, Jordanna M. Barley, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Morgan W. Kelly, Alysha B. Putnam, Seema N. Sheth, Andrew R. Villeneuve, Brian S. Cheng

Faculty Publications

There is considerable uncertainty regarding which ecosystems are most vulnerable to warming. Current understanding of organismal sensitivity is largely centred on species-level assessments that do not consider variation across populations. Here we used meta-analysis to quantify upper thermal tolerance variation across 305 populations from 61 terrestrial, freshwater, marine and intertidal taxa. We found strong differentiation in heat tolerance across populations in marine and intertidal taxa but not terrestrial or freshwater taxa. This is counter to the expectation that increased connectivity in the ocean should reduce intraspecific variation. Such adaptive differentiation in the ocean suggests there may be standing genetic variation …

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Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana Dec 2022

Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana

Faculty Publications

Probiotics are commonly added to yogurt to provide many health benefits for the consumer. A description is provided for some commonly used probiotics in yogurt. A GRAS (generally recognized as safe) list of probiotic bacteria that can be added to yogurt or similar types of products is provided. Additionally, prebiotics, synbiotics (combination of prebiotics and probiotics), postbiotics, paraprobiotics, and psychobiotics can be added to yogurt. Probiotic yogurt can come in various forms in addition to spoonable yogurt, and yogurt can be used as an ingredient in other food products. Many useful functional ingredients can be applied to probiotic yogurt. The …

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