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A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel Dec 2023

A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel

Faculty Publications

Mosquitoes are a known public nuisance and can vector various diseases. Historically, New Orleans, LA, has long been acquainted with the burden of mosquito-borne diseases, such as malaria and yellow fever in the 20th century and West Nile virus in the 21st century. Government mosquito control awareness campaigns have been around for decades as has the use of organophosphate and pyrethroid insecticides by mosquito abatement districts. However, few data are available on public perception of mosquito control and public usage of insecticides to kill mosquitoes in New Orleans. We conducted a survey from August 2020 to July 2021 to evaluate …

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Taxonomic Profiling Of Nasutitermes Takasagoensis Microbiota To Investigate The Role Of Termites As Vectors Of Bacteria Linked To Ironwood Tree Decline In Guam, Garima Setia, Junyan Chen, Robert Schlub, Claudia Husseneder Dec 2023

Taxonomic Profiling Of Nasutitermes Takasagoensis Microbiota To Investigate The Role Of Termites As Vectors Of Bacteria Linked To Ironwood Tree Decline In Guam, Garima Setia, Junyan Chen, Robert Schlub, Claudia Husseneder

Faculty Publications

The ironwood tree (Casuarina equisetifolia, family Casuarinaceae), an indigenous agroforestry species in Guam, has been threatened by ironwood tree decline (IWTD) since 2002. Formation of bacterial ooze by the wilt pathogen from the Ralstonia solanacearum species complex and wetwood bacteria (primarily Klebsiella species) has been linked to IWTD. In addition, termite infestation of trees was statistically associated with IWTD. Termites are known carriers of a diverse microbiome. Therefore, we hypothesized that termites could be vectors of bacteria linked to IWTD. To investigate the potential role of termites as pathogen vectors, we employed next-generation 16S rRNA gene sequencing to describe the …

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Building Resilience To Extreme Weather And Climate Events In The Rural Water And Wastewater Sectors, Nathan P. Kettle, Sarah F. Trainor, Renee Edwards, Donald Antrobus, Curt Baranowski, Tina Buxbaum, Kevin Berry, Michael Brubaker, Kristine L. De Long, Steve Fries, Davin Holen, Barry Keim, Danielle Meeker, Harry Penn, Cheryl Rosa, Rick Thoman, John Walsh, Jian Zhang Dec 2023

Building Resilience To Extreme Weather And Climate Events In The Rural Water And Wastewater Sectors, Nathan P. Kettle, Sarah F. Trainor, Renee Edwards, Donald Antrobus, Curt Baranowski, Tina Buxbaum, Kevin Berry, Michael Brubaker, Kristine L. De Long, Steve Fries, Davin Holen, Barry Keim, Danielle Meeker, Harry Penn, Cheryl Rosa, Rick Thoman, John Walsh, Jian Zhang

Faculty Publications

Extreme weather and climate events pose significant risks to rural water and wastewater systems. We examine the vulnerability of the water sector to weather and climate extremes in rural, predominantly Indigenous and underserved coastal areas and analyze how networks support resilience. Drawing on the analysis of 39 web-based questionnaire responses and 19 interviews with rural water and wastewater managers and service providers in southern Louisiana and western Alaska, this article reports a range of interrelated historical, environmental, and social factors that influence vulnerability to extreme weather events. Formal and informal social networks serve multiple roles in building resilience. These roles …

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A Trait Dataset For Freshwater Mussels Of The United States Of America, Garrett W. Hopper, Jamie R. Bucholz, Traci P. Dubose, Kaelyn J. Fogelman, Sean M. Keogh, Megan E. Kubala, Matthew B. Lodato, David H. Nichols, Irene Sánchez González, John M. Pfeiffer, James A. Stoeckel, Jeffrey D. Lozier, Carla L. Atkinson Dec 2023

A Trait Dataset For Freshwater Mussels Of The United States Of America, Garrett W. Hopper, Jamie R. Bucholz, Traci P. Dubose, Kaelyn J. Fogelman, Sean M. Keogh, Megan E. Kubala, Matthew B. Lodato, David H. Nichols, Irene Sánchez González, John M. Pfeiffer, James A. Stoeckel, Jeffrey D. Lozier, Carla L. Atkinson

Faculty Publications

The United States of America has a diverse collection of freshwater mussels comprising 301 species distributed among 59 genera and two families (Margaritiferidae and Unionidae), each having a unique suite of traits. Mussels are among the most imperilled animals and are critical components of their ecosystems, and successful management, conservation and research requires a cohesive and widely accessible data source. Although trait-based analysis for mussels has increased, only a small proportion of traits reflecting mussel diversity in this region has been collated. Decentralized and non-standardized trait information impedes large-scale analysis. Assembling trait data in a synthetic dataset enables comparison across …

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New Insights In The Mechanisms Of Weight-Loss Maintenance: Summary From A Pennington Symposium, Emily W. Flanagan, Redin Spann, Sarah E. Berry, Hans Rudolf Berthoud, Stephanie Broyles, Gary D. Foster, Jonathan Krakoff, Ruth J.F. Loos, Michael R. Lowe, Danielle M. Ostendorf, Tiffany M. Powell-Wiley, Leanne M. Redman, Michael Rosenbaum, Philip R. Schauer, Randy J. Seeley, Boyd A. Swinburn, Kevin Hall, Eric Ravussin Dec 2023

New Insights In The Mechanisms Of Weight-Loss Maintenance: Summary From A Pennington Symposium, Emily W. Flanagan, Redin Spann, Sarah E. Berry, Hans Rudolf Berthoud, Stephanie Broyles, Gary D. Foster, Jonathan Krakoff, Ruth J.F. Loos, Michael R. Lowe, Danielle M. Ostendorf, Tiffany M. Powell-Wiley, Leanne M. Redman, Michael Rosenbaum, Philip R. Schauer, Randy J. Seeley, Boyd A. Swinburn, Kevin Hall, Eric Ravussin

Division of Basic Science Faculty Publications

Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long-term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose …

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Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky Dec 2023

Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky

Faculty Publications

Introduction: Cigarette smoking remains the leading preventable cause of death and disability in the United States and frequently co-occurs with anxiety and depressive symptoms. A novel and integrative, theory-driven approach to address the heterogeneity of mood-related symptoms associated with cigarette use is to focus on transdiagnostic processes, such as distress tolerance, that underpin both mood-related symptoms and smoking behavior. The current study sought to develop and examine the feasibility, acceptability, and initial efficacy of a digitally delivered integrated personalized feedback intervention (PFI) that addresses smoking-distress tolerance relations. Methods: Participants included 121 adults (71.1 % male; Mage = 29.33 years, SD …

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Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch Dec 2023

Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch

Faculty Publications

Aquatic biomedical model organisms play a substantial role in advancing our understanding of human health, however, comparably little work has been directed towards developing dependable, high-throughput storage programs for valuable genetic resources. The Zebrafish International Resource Center (ZIRC) has developed a standardized cryopreservation pathway and stored thousands of genetic lines in their repository for use by the biomedical research community. This has yet to be replicated in other facilities, and an overall repository-level pathway has never been analyzed for aquatic species. To encourage repository development for other biomedical models and to improve the ZIRC storage process and system, this study …

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Dietary Intake During A Pragmatic Cluster-Randomized Weight Loss Trial In An Underserved Population In Primary Care, John W. Apolzan, Corby K. Martin, Robert L. Newton, Candice A. Myers, Connie L. Arnold, Terry C. Davis, William D. Johnson, Dachuan Zhang, Christoph Höchsmann, Vivian A. Fonseca, Kara D. Denstel, Emily F. Mire, Benjamin F. Springgate, Carl J. Lavie, Peter T. Katzmarzyk, Phillip Brantley, Ronald Horswell, Tina K. Thethi, Jonathan Gugel, Eboni Price-Haywood, Kathleen B. Kennedy, Daniel F. Sarpong Dec 2023

Dietary Intake During A Pragmatic Cluster-Randomized Weight Loss Trial In An Underserved Population In Primary Care, John W. Apolzan, Corby K. Martin, Robert L. Newton, Candice A. Myers, Connie L. Arnold, Terry C. Davis, William D. Johnson, Dachuan Zhang, Christoph Höchsmann, Vivian A. Fonseca, Kara D. Denstel, Emily F. Mire, Benjamin F. Springgate, Carl J. Lavie, Peter T. Katzmarzyk, Phillip Brantley, Ronald Horswell, Tina K. Thethi, Jonathan Gugel, Eboni Price-Haywood, Kathleen B. Kennedy, Daniel F. Sarpong

Clinical Research Faculty Publications

Background: Currently there are limited data as to whether dietary intake can be improved during pragmatic weight loss interventions in primary care in underserved individuals. Methods: Patients with obesity were recruited into the PROPEL trial, which randomized 18 clinics to either an intensive lifestyle intervention (ILI) or usual care (UC). At baseline and months 6, 12, and 24, fruit and vegetable (F/V) intake and fat intake was determined. Outcomes were analyzed by repeated-measures linear mixed-effects multilevel models and regression models, which included random cluster (clinic) effects. Secondary analyses examined the effects of race, sex, age, and food security status. Results: …

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The Personalized Nutrition Study (Points): Evaluation Of A Genetically Informed Weight Loss Approach, A Randomized Clinical Trial, Christoph Höchsmann, Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin Dec 2023

The Personalized Nutrition Study (Points): Evaluation Of A Genetically Informed Weight Loss Approach, A Randomized Clinical Trial, Christoph Höchsmann, Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin

Clinical Research Faculty Publications

Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are generally small; however, individual WL varies within diet groups. Genotype patterns may modify diet effects, with carbohydrate-responsive genotypes losing more weight on high-carbohydrate diets (and vice versa for fat-responsive genotypes). We investigated whether 12-week WL (kg, primary outcome) differs between genotype-concordant and genotype-discordant diets. In this 12-week single-center WL trial, 145 participants with overweight/obesity were identified a priori as fat-responders or carbohydrate-responders based on their combined genotypes at ten genetic variants and randomized to a high-fat (n = 73) or high-carbohydrate diet (n = 72), yielding 4 groups: (1) …

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Effect Of An Acute Long-Duration Exercise Bout On Skeletal Muscle Lipid Droplet Morphology, Glut 4 Protein, And Perilipin Protein Expression, Sudip Bajpeyi, Jehu N. Apaflo, Victoria Rosas, Keisha Sepulveda-Rivera, Armando Varela-Ramirez, Jeffrey D. Covington, Jose E. Galgani, Eric Ravussin Dec 2023

Effect Of An Acute Long-Duration Exercise Bout On Skeletal Muscle Lipid Droplet Morphology, Glut 4 Protein, And Perilipin Protein Expression, Sudip Bajpeyi, Jehu N. Apaflo, Victoria Rosas, Keisha Sepulveda-Rivera, Armando Varela-Ramirez, Jeffrey D. Covington, Jose E. Galgani, Eric Ravussin

Clinical Research Faculty Publications

Purpose: Smaller lipid droplet morphology and GLUT 4 protein expression have been associated with greater muscle oxidative capacity and glucose uptake, respectively. The main purpose of this study was to determine the effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT4, perilipin 3, and perilipin 5 expressions. Methods: Twenty healthy men (age 24.0 ± 1.0 years, BMI 23.6 ± 0.4 kg/m2) were recruited for the study. The participants were subjected to an acute bout of exercise on a cycle ergometer at 50% VO2max until they reached a total energy expenditure of 650 kcal. The study …

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Body Shape Perception In Men And Women Without Obesity During Caloric Restriction: A Secondary Analysis From The Calerie Study, Maci M. Jacobson, Alexis M. Gardner, Camilla E. Handley, Michael W. Smith, William F. Christensen, Chad R. Hancock, Paule V. Joseph, Michael J. Larson, Corby K. Martin, James D. Lecheminant Dec 2023

Body Shape Perception In Men And Women Without Obesity During Caloric Restriction: A Secondary Analysis From The Calerie Study, Maci M. Jacobson, Alexis M. Gardner, Camilla E. Handley, Michael W. Smith, William F. Christensen, Chad R. Hancock, Paule V. Joseph, Michael J. Larson, Corby K. Martin, James D. Lecheminant

Clinical Research Faculty Publications

Objective: To examine body shape perception in 218 adults without obesity or history of eating disorders during caloric restriction (CR). Methods: Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) is a 2-year, randomized clinical trial using a 2:1 assignment (CR, 25% reduction in calories; Control, typical diet). For this secondary analysis, we examined perceived body shape using the Body Shape Questionnaire (BSQ). Analyses of BSQ scores are reported by group, over time, by sex, and by BMI. Data for body fat percentage, symptoms of depression, food cravings, maximal oxygen consumption, and stress were analyzed for their association …

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Protocol To Evaluate The Effectiveness And Cost-Effectiveness Of An Environmental Nutrition And Physical Activity Intervention In Nurseries (Nutrition And Physical Activity Self Assessment For Child Care - Nap Sacc Uk): A Multicentre Cluster Randomised Controlled Trial, Ruth Kipping, Miranda Pallan, Kim Hannam, Kate Willis, Alex Dobell, Chris Metcalfe, Russell Jago, Laura Johnson, Rebecca Langford, Corby K. Martin, William Hollingworth, Madeleine Cochrane, James White, Pete Blair, Zoi Toumpakari, Jodi Taylor, Dianne Ward, Laurence Moore, Tom Reid, Megan Pardoe, Liping Wen, Marie Murphy, Anne Martin, Stephanie Chambers, Sharon Anne Simpson Dec 2023

Protocol To Evaluate The Effectiveness And Cost-Effectiveness Of An Environmental Nutrition And Physical Activity Intervention In Nurseries (Nutrition And Physical Activity Self Assessment For Child Care - Nap Sacc Uk): A Multicentre Cluster Randomised Controlled Trial, Ruth Kipping, Miranda Pallan, Kim Hannam, Kate Willis, Alex Dobell, Chris Metcalfe, Russell Jago, Laura Johnson, Rebecca Langford, Corby K. Martin, William Hollingworth, Madeleine Cochrane, James White, Pete Blair, Zoi Toumpakari, Jodi Taylor, Dianne Ward, Laurence Moore, Tom Reid, Megan Pardoe, Liping Wen, Marie Murphy, Anne Martin, Stephanie Chambers, Sharon Anne Simpson

Clinical Research Faculty Publications

Background: One in seven UK children have obesity when starting school, with higher prevalence associated with deprivation. Most pre-school children do not meet UK recommendations for physical activity and nutrition. Formal childcare settings provide opportunities to deliver interventions to improve nutritional quality and physical activity to the majority of 3–4-year-olds. The nutrition and physical activity self-assessment for childcare (NAP SACC) intervention has demonstrated effectiveness in the USA with high acceptability in the UK. The study aims to evaluate the effectiveness and cost-effectiveness of the NAP SACC UK intervention to increase physical activity, reduce sedentary time and improve nutritional intake. Methods: …

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Physiologic Hormone Administration Improves Hba1c In Native Americans With Type 2 Diabetes: A Retrospective Study And Review Of Insulin Secretion And Action, Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway Dec 2023

Physiologic Hormone Administration Improves Hba1c In Native Americans With Type 2 Diabetes: A Retrospective Study And Review Of Insulin Secretion And Action, Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway

Clinical Research Faculty Publications

Insulin is secreted in pulses from pancreatic beta-cells, and these oscillations maintain fasting plasma glucose levels within a narrow normal range. Within islets, beta-cells exhibit tight synchronization of regular oscillations. This control circuit is disrupted in type 2 diabetes, and irregularities in pulse frequency and amplitude occur. The prevalence of type 2 diabetes is three times higher in American Indian and Native Alaskans compared to Whites, and their genetic ancestry is associated with low beta-cell function. Obesity in this population compounds their vulnerability to adverse outcomes. The purpose of this article is to review insulin secretion and action and its …

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Acute Exercise Increases Nk Cell Mitochondrial Respiration And Cytotoxicity Against Triple-Negative Breast Cancer Cells Under Hypoxic Conditions, Eunhan Cho, James Stampley, Rachel Wall, Rachel Matthews, Elizabeth Zunica, Justin C. Brown, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann Dec 2023

Acute Exercise Increases Nk Cell Mitochondrial Respiration And Cytotoxicity Against Triple-Negative Breast Cancer Cells Under Hypoxic Conditions, Eunhan Cho, James Stampley, Rachel Wall, Rachel Matthews, Elizabeth Zunica, Justin C. Brown, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann

Clinical Research Faculty Publications

Purpose Triple-negative breast cancer (TNBC) is an aggressive, highly metastatic malignancy with high recurrence rates. Hypoxia is a hallmark of the TNBC tumor microenvironment, which promotes tumor growth while impairing natural killer (NK) cell cytotoxic functions. Although acute exercise improves NK cell function under normoxic conditions, the effect of exercise on NK cell cytotoxic functions under hypoxic conditions mimicking O2 tensions observed in solid tumors is unknown. Methods The cytotoxic functions of resting and postexercise NK cells isolated from thirteen young inactive healthy women were assessed against breast cancer cells expressing different levels of hormone receptors (MCF-7 and MDA-MB-231) under …

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Seasonal Changes In Physiological And Psychological Parameters Of Stress In Collegiate Swimmers, Haoyan Wang, Bailey M. Theall, Kate S. Early, Cullen Vincellette, Lyle Robelot, Rick L. Sharp, Jack Marucci, Shelly Mullenix, Derek Calvert, Nathan P. Lemoine, Brain A. Irving, Guillaume Spielmann, Neil M. Johannsen Dec 2023

Seasonal Changes In Physiological And Psychological Parameters Of Stress In Collegiate Swimmers, Haoyan Wang, Bailey M. Theall, Kate S. Early, Cullen Vincellette, Lyle Robelot, Rick L. Sharp, Jack Marucci, Shelly Mullenix, Derek Calvert, Nathan P. Lemoine, Brain A. Irving, Guillaume Spielmann, Neil M. Johannsen

Clinical Research Faculty Publications

To investigate the seasonal changes in physiological and psychological parameters of stress in collegiate swimmers. Fifteen NCAA Division I swimmers (8 men) participated in a tethered anaerobic swim test to determine physiological responses in an ecologically-relevant, graded exercise test. Wisconsin Upper Respiratory Symptom Survey (WURSS-21), Activation-Deactivation Adjective Check List (AD-ACL), Daily Analysis of Life Demands of Athletes (DALDA), and Pittsburgh Sleep Quality Index were assessed at post-season in April (V1), the end of off-season in June (V2), and pre-season in October (V3). The percent change was determined from V2–V1 (off-season phase), V3–V2 (pre-season phase), V1–V3 (in-season phase). Spearman’s rho correlation …

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An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina Dec 2023

An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina

Clinical Research Faculty Publications

Background: Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics. Methods: The Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention …

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An Examination Of The Relationships Between The Neighborhood Social Environment, Adiposity, And Cardiometabolic Disease Risk In Adolescence: A Cross-Sectional Study, Kara D. Denstel, Robbie A. Beyl, Denise M. Danos, Maura M. Kepper, Amanda E. Staiano, Katherine T. Theall, Tung Sung Tseng, Stephanie T. Broyles Dec 2023

An Examination Of The Relationships Between The Neighborhood Social Environment, Adiposity, And Cardiometabolic Disease Risk In Adolescence: A Cross-Sectional Study, Kara D. Denstel, Robbie A. Beyl, Denise M. Danos, Maura M. Kepper, Amanda E. Staiano, Katherine T. Theall, Tung Sung Tseng, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

Background: Disadvantaged neighborhood environments are a source of chronic stress which undermines optimal adolescent health. This study investigated relationships between the neighborhood social environment, specifically, chronic stress exposures, adiposity, and cardiometabolic disease risk factors among 288 Louisiana adolescents aged 10 to 16 years. Methods: This cross-sectional study utilized baseline data from the Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) study. Adolescent data were obtained using self-reported questionnaires (demographics and perceived neighborhood disorder), anthropometry, body imaging, and a blood draw while objective neighborhood data for the concentrated disadvantage index were acquired from the 2016 American Community Survey …

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Adolescent Diet Quality, Cardiometabolic Risk, And Adiposity: A Prospective Cohort, Kathy Hu, Alyssa M. Button, Claire M. Tate, Chelsea L. Kracht, Catherine M. Champagne, Amanda E. Staiano Dec 2023

Adolescent Diet Quality, Cardiometabolic Risk, And Adiposity: A Prospective Cohort, Kathy Hu, Alyssa M. Button, Claire M. Tate, Chelsea L. Kracht, Catherine M. Champagne, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Objective: Examine the prospective association among diet with adolescent cardiometabolic risk (CMR) and anthropometrics. Methods: Secondary analysis of an observational study of adolescents aged 10–16 years. Twenty-four-hour food recalls were used to calculate Healthy Eating Index-2015 (HEI-2015) scores. Anthropometrics were assessed using magnetic resonance imaging, dual-energy x-ray absorptiometry, and height/weight measurements. CMR included mean arterial pressure, homeostatic model assessment for insulin resistance, high-density lipoprotein cholesterol, and triglycerides. Associations between HEI-2015 score at baseline with follow-up adiposity and CMR were examined using regression models. Results: A total of 192 adolescents were included. Baseline HEI-2015 scores were inversely associated with follow-up total …

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Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel Dec 2023

Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel

Population and Public Health Science Faculty Publications

No abstract provided.

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Adherence To Recess Guidelines In The United States Using Nationally Representative Data: Implications For Future Surveillance Efforts, Kimberly A. Clevenger, Genevieve F. Dunton, Peter T. Katzmarzyk, Karin A. Pfeiffer, David Berrigan Dec 2023

Adherence To Recess Guidelines In The United States Using Nationally Representative Data: Implications For Future Surveillance Efforts, Kimberly A. Clevenger, Genevieve F. Dunton, Peter T. Katzmarzyk, Karin A. Pfeiffer, David Berrigan

Population and Public Health Science Faculty Publications

BACKGROUND: National adherence to the recess recommendations of the Centers for Disease Control and Prevention (CDC) has not been comprehensively studied in the United States. METHODS: Data from 6 nationally representative data sets over the last decade (Classification of Laws Associated with School Students, Early Childhood Longitudinal Study, National Health and Nutrition Examination Survey, National Youth Fitness Survey, School Health Policies and Practices Survey, and the School Nutrition and Meal Cost Study) provided estimates for adherence to CDC recess guidelines. RESULTS: While approximately 65-80% of elementary school-children receive the recommended 20+ minutes of daily recess according to parent-, principal-, and …

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Ketogenic Propensity Is Differentially Related To Lipid-Induced Hepatic And Peripheral Insulin Resistance, J. T. Mey, B. Vandagmansar, W. S. Dantas, K. P. Belmont, C. L. Axelrod, J. P. Kirwan Dec 2023

Ketogenic Propensity Is Differentially Related To Lipid-Induced Hepatic And Peripheral Insulin Resistance, J. T. Mey, B. Vandagmansar, W. S. Dantas, K. P. Belmont, C. L. Axelrod, J. P. Kirwan

Division of Basic Science Faculty Publications

Aim: Determine the ketogenic response (β-hydroxybutyrate, a surrogate of hepatic ketogenesis) to a controlled lipid overload in humans. Methods: In total, nineteen young, healthy adults (age: 28.4 ± 1.7 years; BMI: 22.7 ± 0.3 kg/m2) received either a 12 h overnight lipid infusion or saline in a randomized, crossover design. Plasma ketones and inflammatory markers were quantified by colorimetric and multiplex assays. Hepatic and peripheral insulin sensitivity was assessed by the hyperinsulinemic–euglycemic clamp. Skeletal muscle biopsies were obtained to quantify gene expression related to ketone body metabolism and inflammation. Results: By design, the lipid overload-induced hepatic (50%, p < 0.001) and peripheral insulin resistance (73%, p < 0.01) in healthy adults. Ketones increased with hyperlipidemia and were subsequently reduced with hyperinsulinemia during the clamp procedure (Saline: Basal = 0.22 mM, Insulin = 0.07 mM; Lipid: Basal = 0.78 mM, Insulin = 0.51 mM; 2-way ANOVA: Lipid p < 0.001, Insulin p < 0.001, Interaction p = 0.07). In the saline control condition, ketones did not correlate with hepatic or peripheral insulin sensitivity. Conversely, in the lipid condition, ketones were positively correlated with hepatic insulin sensitivity (r = 0.59, p < 0.01), but inversely related to peripheral insulin sensitivity (r = −0.64, p < 0.01). Hyperlipidemia increased plasma inflammatory markers, but did not impact skeletal muscle inflammatory gene expression. Gene expression related to ketone and fatty acid metabolism in skeletal muscle increased in response to hyperlipidemia. Conclusion: This work provides important insight into the role of ketones in human health and suggests that ketone body metabolism is altered at the onset of lipid-induced insulin resistance.

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Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel Dec 2023

Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Background: Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology. Methods: Systematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual data were extracted and duplicates were removed. Outcomes were analysed for each gene and intervention, and in aggregate for partial, generalised and all lipodystrophy. Results: 10 non-randomised experimental studies, 8 case series, and 23 case reports meet inclusion criteria, all rated as having …

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Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds Dec 2023

Participant Characteristics In The Prevention Of Gestational Diabetes As Evidence For Precision Medicine: A Systematic Review And Meta-Analysis, Siew Lim, Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. This study aimed to systematically evaluate the participant characteristics associated with responses to interventions in gestational diabetes mellitus (GDM) prevention. Methods: We searched MEDLINE, EMBASE, and Pubmed to identify lifestyle (diet, physical activity, or both), metformin, myoinositol/inositol and probiotics interventions of GDM prevention published up to May 24, 2022. Results: From 10347 studies, 116 studies (n = 40940 women) are included. Physical activity results in greater GDM reduction in participants with a normal body mass index (BMI) at baseline compared to …

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Precision Subclassification Of Type 2 Diabetes: A Systematic Review, Shivani Misra, Shivani Misra, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Liana K. Billings, Robert H. Eckel, Wayne Huey Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, Paul W. Franks, Stephen S. Rich, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting Dec 2023

Precision Subclassification Of Type 2 Diabetes: A Systematic Review, Shivani Misra, Shivani Misra, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Liana K. Billings, Robert H. Eckel, Wayne Huey Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, Paul W. Franks, Stephen S. Rich, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting

Clinical Research Faculty Publications

Background: Heterogeneity in type 2 diabetes presentation and progression suggests that precision medicine interventions could improve clinical outcomes. We undertook a systematic review to determine whether strategies to subclassify type 2 diabetes were associated with high quality evidence, reproducible results and improved outcomes for patients. Methods: We searched PubMed and Embase for publications that used ‘simple subclassification’ approaches using simple categorisation of clinical characteristics, or ‘complex subclassification’ approaches which used machine learning or ‘omics approaches in people with established type 2 diabetes. We excluded other diabetes subtypes and those predicting incident type 2 diabetes. We assessed quality, reproducibility and clinical …

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Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs Dec 2023

Precision Gestational Diabetes Treatment: A Systematic Review And Meta-Analyses, Jamie L. Benham, Véronique Gingras, Niamh Maire Mclennan, Jasper Most, Jennifer M. Yamamoto, Catherine E. Aiken, Susan E. Ozanne, Susan E. Ozanne, Rebecca M. Reynolds, Rebecca M. Reynolds, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition has wide-ranging beneficial effects. However, despite the known heterogeneity in GDM, treatment guidelines and approaches are generally standardized. We hypothesized that a precision medicine approach could be a tool for risk-stratification of women to streamline successful GDM management. With the relatively short timeframe available to treat GDM, commencing effective therapy earlier, with more rapid normalization of hyperglycaemia, could have benefits for both mother and fetus. Methods: We …

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Impact Of Individual And Environmental Factors On Dietary Or Lifestyle Interventions To Prevent Type 2 Diabetes Development: A Systematic Review, Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy Dec 2023

Impact Of Individual And Environmental Factors On Dietary Or Lifestyle Interventions To Prevent Type 2 Diabetes Development: A Systematic Review, Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy

Clinical Research Faculty Publications

Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect …

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The Use Of Precision Diagnostics For Monogenic Diabetes: A Systematic Review And Expert Opinion, Rinki Murphy, Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Viswanathan Mohan, Shivani Misra, James B. Meigs Dec 2023

The Use Of Precision Diagnostics For Monogenic Diabetes: A Systematic Review And Expert Opinion, Rinki Murphy, Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summarized resources for (3) considering a gene or (4) variant as causal for monogenic diabetes, provided expert recommendations for (5) reporting of results; and reviewed (6) next steps after monogenic diabetes diagnosis and (7) challenges in precision medicine field. Methods: Pubmed and Embase databases were searched (1990-2022) using inclusion/exclusion criteria for studies that sequenced one or more monogenic diabetes genes in at least 100 probands (Question 1), evaluated a non-obsolete …

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Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng Dec 2023

Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng

Clinical Research Faculty Publications

Background: A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy. Methods: We performed a pre-registered systematic review of meta-analysis studies, randomized control trials, and observational studies evaluating clinical and biological features associated with heterogenous treatment effects for SGLT2-inhibitor and GLP1-receptor agonist therapies, considering glycaemic, cardiovascular, and renal outcomes. After screening 5,686 studies, we included 101 studies of SGLT2-inhibitors and 75 studies …

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Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman Dec 2023

Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman

Clinical Research Faculty Publications

Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a …

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The Partner-An Underutilized Facilitator To Support Healthy Gestational Weight Gain, Joshua R. Sparks, Suzanne Phelan, Kimberly L. Drews, Leanne M. Redman Dec 2023

The Partner-An Underutilized Facilitator To Support Healthy Gestational Weight Gain, Joshua R. Sparks, Suzanne Phelan, Kimberly L. Drews, Leanne M. Redman

Clinical Research Faculty Publications

No abstract provided.

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