Digital Commons Network^™

Long-Term Outcomes Of Metabolic Surgery Versus Medical/Lifestyle Therapy On Metabolic Dysfunction-Associated Fatty Liver Disease In Adults With Obesity And Type 2 Diabetes, Michelle D. Lundholm, Sarah Kirschling, Bo Hu, Ali Aminian, David E. Arterburn, Anita P. Courcoulas, David E. Cummings, William F. Gourash, Mary Elizabeth Patti, Philip R. Schauer, Donald C. Simonson, Ashley H. Vernon, John P. Kirwan, Sangeeta R. Kashyap

Division of Basic Science Faculty Publications

No abstract provided.

Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Klasson, I. M. Lima, J. L. Purswell, M. Souliman, E. Terrell, B. S. Tubaña, H. L. Waguespack, J. J. Wang, P. M. White

Faculty Publications

Abstract: Sugarcane (Saccharum officinarum) is Louisiana's number one row crop. Growing and processing sugarcane produces significant amounts of byproducts, including bagasse, crop residue, molasses, filter-press mud, and boiler fly ash. These products represent an important opportunity to generate value-added and specialty products and enhance sugarcane's sustainability by facilitating a circular economy, where agricultural by-products are reused instead of disposing them (linear economy), in order to reduce resource use and energy demand. Examples of value-added products range from biochar, construction materials, animal feed, biofuels, nanoparticles, and fertilizer. Paramount to the success of the bio-based circular economy is creating useful products that …

Management Strategies For Preventing And Recovering From Bermudagrass Winterkill, W. J. Hutchens, T. Q. Carr, A. J. Patton, C. A. Bigelow, E. J. Deboer, J. M. Goatley, D. L. Martin, D. S. Mccall, G. L. Miller, J. S. Powlen, M. D. Richardson, M. Xiang

Faculty Publications

Bermudagrass (Cynodon spp. Rich) is a warm-season grass that is widely planted throughout tropical, sub-tropical, and even temperate climates, and it generally requires fewer inputs than most cool-season turfgrasses. In recent years, the area of adaptation for bermudagrass has progressively expanded to cooler climates due to the development of more cold-tolerant cultivars. The expanded area of adaptation as well as the reduced inputs required to maintain healthy turfgrass have made bermudagrass a popular choice in areas of marginal adaptation. In these areas, the greatest threat to bermudagrass health and survivability is winterkill. This management guide seeks to describe winterkill: what …

Metabolic Scaling, Energy Allocation Tradeoffs, And The Evolution Of Humans’ Unique Metabolism, Andrew K. Yegian, Steven B. Heymsfield, Eric R. Castillo, Manfred J. Müller, Leanne M. Redman, Daniel E. Lieberman

Clinical Research Faculty Publications

All organisms use limited energy to grow, survive, and reproduce, necessitating energy allocation tradeoffs, but there is debate over how selection impacted metabolic budgets and tradeoffs in primates, including humans. Here, we develop a method to compare metabolic rates as quotients of observed relative to expected values for mammals corrected for size, body composition, environmental temperature, and phylogenetic relatedness. Contrary to previous analyses, these quotients reveal that nonhuman primates have total metabolic rates expected for similar-sized mammals in similar environments. In addition, data from several small-scale societies show that humans evolved exceptionally high resting, activity, and total metabolic rates apparently …

Pooled Analysis Of Physical Activity, Sedentary Behavior, And Sleep Among Children From 33 Countries, Kar Hau Chong, Thomas Suesse, Penny L. Cross, Sarah T. Ryan, Eivind Aadland, Oluwayomi Aoko, Ankhmaa Byambaa, Valerie Carson, Jean Philippe Chaput, Hayley Christian, Dylan P. Cliff, Marieke De Craemer, Clarice Maria De Lucena Martins, Christine Delisle Nyström, Catherine E. Draper, Asmaa El Hamdouchi, Alex Antonio Florindo, Hongyan Guan, Amy S. Ha, Najmeh Hamzavi Zarghani, Kylie D. Hesketh, Mohammad Sorowar Hossain, Jajat Jajat, Thanh Kim, Denise Koh, Anna V. Kontsevaya, Nicholas Kuzik, Marja H. Leppänen, Marie Löf, Himangi Lubree, Kim Meredith-Jones, Tawonga W. Mwase-Vuma, Johan Y.Y. Ng, Rachel Novotny

Population and Public Health Science Faculty Publications

Importance: The prevalence estimates of physical activity, sedentary behavior, and sleep (collectively known as movement behaviors) in 3-and 4-year-old children worldwide remains uncertain. Objective: To report the proportion of 3-and 4-year-old children who met the World Health Organization guidelines for physical activity, sedentary behavior, and sleep across 33 countries. Design, Setting, and Participants: Pooled analysis of data from 14 cross-sectional studies (July 2008 to September 2022) identified through systematic reviews and personal networks. Thirty-Three countries of varying income levels across 6 geographical regions. Each study site needed to have at least 40 children aged 3.0 to 4.9 years with valid …

Calculation And Comparison Of Step Guidelines For Preschooler Physical Activity While Indoors, Halle Roman, Leanne M. Redman, Cody D. Neshteruk, Derek Hales, Brian Helsel, Chelsea L. Kracht

Clinical Research Faculty Publications

Objectives: Preschooler physical activity (PA) is vital for growth and development. The World Health Organization PA guidelines state preschoolers should achieve ≥ 180 min/day of Total PA (TPA) of which ≥ 60 min is moderate-to-vigorous PA (MVPA). A step/day recommendation to match these guidelines may be a more practical metric for caregivers to promote PA. The purpose of our investigation is to improve upon existing step recommendations by creating one for indoor-based activities, acknowledging where preschoolers spend most of their time, and various cut-points for PA. Methods: In a laboratory study (Aim 1), a validated direct observation protocol was used …

In Silico And Functional Analysis Identifies Key Gene Networks And Novel Gene Candidates In Obesity-Linked Human Visceral Fat, Lijin Wang, Pratap Veerabrahma Seshachalam, Ruiming Chua, Hongwen Zhou, Sun Lei, Sujoy Ghosh

Division of Basic Science Faculty Publications

Objective: Visceral adiposity is associated with increased proinflammatory activity, insulin resistance, diabetes risk, and mortality rate. Numerous individual genes have been associated with obesity, but studies investigating gene regulatory networks in human visceral obesity have been lacking. Methods: We analyzed gene regulatory networks in human visceral adipose tissue (VAT) from 48 and 11 Chinese patients with and without obesity, respectively, using gene coexpression and gene regulatory network construction from RNA-sequencing data. We also conducted RNA interference-based functional tests on selected genes for effects on adipocyte differentiation. Results: A scale-free gene coexpression network was constructed from 360 differentially expressed genes between …

Healthy Lifestyle And Cardiac Rehabilitation For Weight Loss, Christoph Höchsmann, James L. Dorling, Carl J. Lavie, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Purpose of Review: Considerable current interest is directed at pharmacological agents for producing significant weight loss. However, healthy lifestyle choices can also lead to clinically meaningful weight loss and improvements in cardiovascular disease (CVD) risk factors. Recent Findings: In this review, we summarize the recent research from our PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) randomized controlled trial and review previous data on the potential benefits of cardiac rehabilitation and exercise training (CRET) programs to produce weight loss and improvements in CVD risk factors. Summary: Although obesity medications are becoming extremely attractive for secondary and even primary …

Metabolomic Fingerprints Of Medical Therapy Versus Bariatric Surgery In Patients With Obesity And Type 2 Diabetes: The Stampede Trial, Christopher L. Axelrod, Adithya Hari, Wagner S. Dantas, Sangeeta R. Kashyap, Philip R. Schauer, John P. Kirwan

Division of Basic Science Faculty Publications

Objective: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are effective procedures to treat and manage type 2 diabetes (T2D). However, the underlying metabolic adaptations that mediate improvements in glucose homeostasis remain largely elusive. The purpose of this study was to identify metabolic signatures associated with biochemical resolution of T2D after medical therapy (MT) or bariatric surgery. Research Design and Methods: Plasma samples from 90 patients (age 49.9 ± 7.6 years; 57.7% female) randomly assigned to MT (n = 30), RYGB (n = 30), or SG (n = 30) were retrospectively subjected to untargeted metabolomic analysis using ultra performance liquid …

Prediction Of Individual Weight Loss Using Supervised Learning: Findings From The CalerieTm 2 Study, Christina Glasbrenner, Christoph Höchsmann, Carl F. Pieper, Paulina Wasserfurth, James L. Dorling, Corby K. Martin, Leanne M. Redman, Karsten Koehler

Clinical Research Faculty Publications

Background: Predicting individual weight loss (WL) responses to lifestyle interventions is challenging but might help practitioners and clinicians select the most promising approach for each individual. Objective: The primary aim of this study was to develop machine learning (ML) models to predict individual WL responses using only variables known before starting the intervention. In addition, we used ML to identify pre-intervention variables influencing the individual WL response. Methods: We used 12-mo data from the comprehensive assessment of long-term effects of reducing intake of energy (CALERIETM) phase 2 study, which aimed to analyze the long-term effects of caloric restriction on human …

Digital Agriculture Approaches: Uav-Based N Monitoring And Machine Learning For Maize Yield Prediction, And N Response Assessment Across Rice Varieties, Rejina Adhikari

LSU Master's Theses

Sustainable agriculture is essential for addressing global challenges such as food security, environmental degradation, and climate change while ensuring high productivity and resource conservation. Precision agriculture technologies, like UAV-based remote sensing and advanced sensors, offer tools to monitor real-time crop health, soil conditions, and nutrient levels, aiding in informed decision-making and resource optimization. In this research, field trials were conducted in maize and rice to assess the effectiveness of NDRE (Normalized Difference Red Edge) obtained from UAV-based remote sensing for nitrogen management. For maize, the study demonstrated that NDRE accurately assessed nitrogen levels during critical growth stages, with yields ranging …

Improving Rice Yield Using Sensor Based Nitrogen Application And Best Management Practices (Bmps) In Rice-Soybean And Rice-Crawfish Rotational Systems, Charles Darnall

LSU Master's Theses

Sustainable rice farming requires effective nutrient management and conservation practices to maintain high yields and minimize environmental impact. Implementing best management practices (BMPs) promotes lower fertilizer application rates, increased N use efficiency, improves soil health, and water quality. Demonstration fields established in two different rotational cropping systems (rice-soybean and rice-crawfish) in Kaplan, LA in 2023. In each rotation system, the benefits of BMPs (sensor based mid-season N management and cover cropping) compared to farmer’s practice (FP) were evaluated using yield, yield components, soil and water quality as metrics. The rice-soybean fields in 2023 and 2024 were both planted with PVL03 …

The Identity Of A Gymnast: How Health, Wellbeing, And Injury Become Embodied In The Identity Of Collegiate Gymnasts, Skyler M. Yakes

LSU Master's Theses

Gymnastics scholarship has traditionally focused on the physicality of the sport and what the body can and cannot do. This research expands upon gymnastics scholarship by exploring the individual experiences and histories of college gymnasts in the United States through a series of interviews. The goals of this research are to better understand the gymnastics experience and to explore health and wellbeing in gymnastics as it pertains to the formation of a gymnast’s identity. A combined approach using medical anthropology and anthropology of sport serves as a guiding framework for analyzing interview data. Definitions of health and wellbeing change between …

Enhancing Writing By Increasing Metacognitive Skills Through Socratic Seminars In A High Poverty Middle School Social Studies Classroom: An Intrinsic Case Study, Kirsten Hickingbottom

LSU Doctoral Dissertations

The purpose of this intrinsic case study was to better understand the role metacognitive skills play within classroom settings to increase students’ writing through Socratic Seminars. A predominant question guided this study: Can improving student metacognition through the repetitive use of questioning techniques in Socratic Seminars lead to improved writing skills? This question, along with four additional research questions guided the research. There is a need for more activities that promote metacognition due to its correlation with academic achievement, critical thinking skills, problem-solving abilities, and perceived self-efficacy (Keus, 2020). The significance of this study was to examine a method of …

Exploring The Interconnectivity Between Soilless Substrate Hydraulic Properties And Plant Root Morphology, Kristopher S. Criscione

LSU Doctoral Dissertations

Horticultural container production heavily relies upon porous soilless substrates to mass produce specialty crops. Soilless substrates are responsible for continuously maintaining optimal water, mineral nutrients, and air balances to promote healthy root growth and support productive shoot yield (foliage or fruit). Increasing evidence of substrate research continues to highlight the strong relationships associated with root development and substrate physiochemical properties. Despite the importance of the root system for overall plant health, most horticultural research to-date has focused on shoot development. Research tends to report total root biomass as the primary root-growth metric; however, this results in several developmental features becoming …

Identification And Characterization Of Resistance To Meloidogyne Enterolobii And M. Incognita In Sweetpotato Genotypes, David M. Galo Espinal

LSU Doctoral Dissertations

Root-knot nematodes (RKN), Meloidogyne spp., are significant agricultural pests that cause severe economic losses on a wide range of agricultural crops worldwide, including sweetpotato. The economic viability of the sweetpotato industry in the United States is threatened by Meloidogyne enterolobii, which reproduces on sweetpotato cultivars resistant to other RKN species. To address this issue, 69 sweetpotato genotypes were evaluated to identify sources of resistance to M. enterolobii (Me) and M. incognita (Mi). Results showed that twenty-six genotypes were highly resistant to Me and eleven were resistant to Mi, with three genotypes showing resistance to …

Coastal Wetlands In The Anthropocene, John Day, Edward Anthony, Robert Costanza, Douglas Edmonds, Joel Gunn, Charles Hopkinson, Michael E. Mann, James Morris, Michael Osland, Tracy Quirk, Andre Rovai, John Rybczyk, Thomas Spencer, Jessica Stephens, Jaia Syvitski, Robert Twilley, Jenneke Visser, John R. White

Faculty Publications

We review the functioning and sustainability of coastal marshes and mangroves. Urbanized humans have a 7,000-year-old enduring relationship to coastal wetlands. Wetlands include marshes, salt flats, and saline and freshwater forests. Coastal wetlands occur in all climate zones but are most abundant in deltas. Mangroves are tropical, whereas marshes occur from tropical to boreal areas. Quantification of coastal wetland areas has advanced in recent years but is still insufficiently accurate. Climate change and sea-level rise are predicted to lead to significant wetland losses and other impacts on coastal wetlands and the humans associated with them. Landward migration and coastal retreat …

Identification Of An Ionic Mechanism For Erα-Mediated Rapid Excitation In Neurons, Meng Yu, Na Yin, Bing Feng, Peiyu Gao, Kaifan Yu, Hesong Liu, Hailan Liu, Yongxiang Li, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Longlong Tu, Jonathan C. Bean, Qingzhuo Liu, Yue Deng, Yuxue Yang, Junying Han, Sanika V. Jossy, Megan L. Burt, Huey Zhong Wong, Yongjie Yang, Benjamin R. Arenkiel, Yang He, Shaodong Guo, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Zhao Wang, Chunmei Wang, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

The major female ovarian hormone, 17β-estradiol (E2), can alter neuronal excitability within milliseconds to regulate a variety of physiological processes. Estrogen receptor-α (ERα), classically known as a nuclear receptor, exists as a membrane-bound receptor to mediate this rapid action of E2, but the ionic mechanisms remain unclear. Here, we show that a membrane channel protein, chloride intracellular channel protein-1 (Clic1), can physically interact with ERα with a preference to the membrane-bound ERα. Clic1-mediated currents can be enhanced by E2 and reduced by its depletion. In addition, Clic1 currents are required to mediate the E2-induced rapid excitations in multiple brain ERα …

On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup

Clinical Research Faculty Publications

Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate–insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a …

Four-Year Follow-Up Of Weight Loss Maintenance Using Electronic Medical Record Data: The Propel Trial, Peter T. Katzmarzyk, Emily F. Mire, Ronald Horswell, San T. Chu, Dachuan Zhang, Corby K. Martin, Robert L. Newton, John W. Apolzan, Eboni G. Price-Haywood, Dan Fort, Thomas W. Carton, Kara D. Denstel

Clinical Research Faculty Publications

Rationale: Short-term weight loss is possible in a variety of settings. However, long-term, free-living weight loss maintenance following structured weight loss interventions remains elusive. Objective: The purpose was to study body weight trajectories over 2 years of intensive lifestyle intervention (ILI) and up to 4 years of follow-up versus usual care (UC). Methods: Data were obtained from electronic medical records (EMRs) from participating clinics. Baseline (Day 0) was established as the EMR data point closest but prior to the baseline date of the trial. The sample included 111 ILI and 196 UC patients. The primary statistical analysis focused on differentiating …

Precision Interventions Targeting The Maternal Metabolic Milieu For Healthy Pregnancies In Obesity, Alexandra M. Niclou, Hannah E. Cabre, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight. Recent Findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies …

Exercise In The Management Of Polycystic Ovary Syndrome: A Position Statement From Exercise And Sports Science Australia, Angelo Sabag, Rhiannon K. Patten, Alba Moreno-Asso, Giorgia E. Colombo, Xela Dafauce Bouzo, Lisa J. Moran, Cheryce Harrison, Maryam Kazemi, Aya Mousa, Chau Tien Tay, Angelica Lindén Hirschberg, Leanne M. Redman, Helena J. Teede

Clinical Research Faculty Publications

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition amongst females of reproductive age, leading to lifelong cardiometabolic, reproductive, psychological, and dermatologic symptoms as well as a reduced quality of life. Lifestyle interventions, which can include structured exercise programmes delivered by appropriately trained exercise professionals such as clinical exercise physiologists, are considered first-line strategies in PCOS management due to their therapeutic effects on various health outcomes and quality of life. This position statement builds on the 2023 International Evidence-based Guideline for the Assessment and Management of PCOS and describes the role of the exercise professional in the context of …

From Pre-Clinical Efficacy To Promising Clinical Trials That Delay Type 1 Diabetes, J. Jason Collier, Daniel S. Hsia, Susan J. Burke

Division of Basic Science Faculty Publications

Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic modulation of the immune system. In this Perspective, we discuss the pharmaceutical strides achieved, traversing from pre-clinical validation to the execution of impactful clinical trials. We begin with the initial investigations involving cyclosporine and glucocorticoids in rodent models, such as the non-obese diabetic (NOD) mouse, which guided early clinical trials. We then discuss the pre-clinical studies using suitable mouse models that eventually led to contemporary clinical trials targeting immune cell functionality and cytokine signaling pathways. Collectively, these discoveries …

Health Literacy Directed Weight Loss Intervention In Primary Care Clinics, Terry Davis, Connie Arnold, Dachuan Zhang, Corby K. Martin, Robert L. Newton, Candice Myers, Kara D. Denstel, Emily F. Mire, Christoph Höchsmann, John Apolzan, Peter T. Katzmarzyk

Clinical Research Faculty Publications

BACKGROUND: Low income and low health literacy are associated with poorer health knowledge, health behaviors and poor health outcomes. The effectiveness of health literacy-directed weight loss treatment interventions in primary care clinics is lacking. OBJECTIVE: The aim of this study was to conduct a pragmatic cluster-randomized trial (PROmoting Successful Weight Loss in Primary CarE in Louisiana ([PROPEL]) to test the effectiveness of a 24-month, patient-centered, literacy-directed obesity treatment program delivered within primary care in an underserved population. This study reports the association between health literacy and program effectiveness, examining potential correlates of weight loss related to patient adherence to the …

Louisiana Agriculture Magazine, Fall 2024

Louisiana Agriculture

Questions drive the science behind the LSU AgCenter. Researcher Erin Oberhaus wanted to find data to help educate Louisiana horse owners about the use of an important medication, and a water quality specialist wondered if noneconomic bodies of water, which include agricultural ponds, might help people generate electricity. The research projects that grew from their questions are detailed in this issue of Louisiana Agriculture.

Also in this issue, scientists share the results from important soybean studies, and the AgCenter farm to school team shares success stories from school gardens across the state.

Research is at the core of the LSU …

The Past And Future Of The Fisheries And Marine Ecosystem Model Intercomparison Project, Camilla Novaglio, Andrea Bryndum-Buchholz, Derek P. Tittensor, Tyler D. Eddy, Heike K. Lotze, Cheryl S. Harrison, Ryan F. Heneghan, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Kelsey E. Roberts, Julia L. Blanchard

Faculty Publications

Climate change is increasingly affecting the world's ocean ecosystems, necessitating urgent guidance on adaptation strategies to limit or prevent catastrophic impacts. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) is a network and framework that provides standardised ensemble projections of the impacts of climate change and fisheries on ocean life and the benefits that it provides to people. Since its official launch in 2013 as a small, self-organized project within the larger Inter-Sectoral Impact Model Intercomparison Project, the FishMIP community has grown substantially and contributed to key international policy processes, such as the Intergovernmental Panel on Climate Change Assessment …

Closing The Gap Between Evidence And Practice For Childhood Obesity Treatment, Alyssa M. Button, Amanda E. Staiano, Hilary K. Seligman

Population and Public Health Science Faculty Publications

No abstract provided.

Energetics Of A World-Tour Female Road Cyclist During A Multistage Race (Tour De France Femmes), Jose L. Areta, Emily Meehan, Georgie Howe, Leanne M. Redman

Clinical Research Faculty Publications

Despite the increased popularity of female elite road cycling, research to inform the fueling requirements of these endurance athletes is lacking. In this case study, we report for the first time the energetics of a female world-tour cyclist competing in the 2023 Tour de France Femmes, an 8-day race of the Union Cycliste Internationale. The 29-year-old athlete presented with oligomenorrhea and low T3 before the race. Total daily energy expenditure assessed with the doubly labeled water technique was 7,572 kcal/day (∼4.3 physical activity levels), among the highest reported in the literature to date for a female. Crank-based mean maximal power …

Determining Diabetic Kidney Disease Severity Using Traditional Chinese Medicine Syndrome Classification, Amanda Yun Rui Lam, Huang Fang Zheng, Kok Keong Teo, Xiao Hui Xin, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Hong Chang Tan

Division of Basic Science Faculty Publications

No abstract provided.

Autonomic And Enteric Profiling May Help Predict Response To Diverse Obesity Therapies, Michael Eiswerth, Prateek Mathur, Hani Rashed, Frank Greenway, Eric Ravussin, William Johnson, Pichamol Jirapinyo, Christopher C. Thompson, Farid Kehdy, Shabnam Sarker, Le Yu Naing, Michael W. Daniels, Thomas Abell

Clinical Research Faculty Publications

Purpose: Changes in autonomic (ANS) and enteric nervous systems (ENS) may be involved in pathogenesis of obesity. We hypothesized that baseline autonomic and enteric parameters may predict outcomes of diverse obesity therapies. Material and Methods: We studied ANS and ENS physiology in 37 patients (8 male, 29 female, age 45 years, weight 129.7 kg) at 4 centers in patients undergoing medical (9: low-calorie diet) versus invasive (22: 16 sleeve, 6 bypass) and semi-invasive (6: 2 band, 2 high energy stimulation, 2 aspiration) weight loss therapies. Weight loss was reported as percent weight loss from baseline to latest values at 1 …