Digital Commons Network^™

Fgf21 And The Physiological Regulation Of Macronutrient Preference, Cristal M. Hill, Emily Qualls-Creekmore, Hans Rudolf Berthoud, Paul Soto, Sangho Yu, David H. Mcdougal, Heike Münzberg, Christopher D. Morrison

Division of Basic Science Faculty Publications

The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conserve existing nutrient stores and promote the ingestion of the missing nutrient, and that these homeostatic responses are mediated, at least in part, by nutritionally regulated hormones acting within the brain. This review highlights recent research that suggests that the metabolic hormone fibroblast growth factor 21 (FGF21) acts on the brain to homeostatically alter macronutrient preference. …

Body Mass Index And Movement Behaviors Among Schoolchildren From 13 Countries Across A Continuum Of Human Development Indices: A Multinational Cross-Sectional Study, Taru Manyanga, Joel D. Barnes, Jean Philippe Chaput, Michelle Guerrero, Peter T. Katzmarzyk, Emily F. Mire, Antonio Prista, Mark S. Tremblay

Population and Public Health Science Faculty Publications

Objective: This study describes the distributions of body mass index (BMI) and movement behaviors among schoolchildren from 13 countries across a continuum of human development. Methods: Data were from a cross-sectional study of 9-11-year-old children (n = 8055) recruited from 269 urban schools in 13 countries, and an additional 7 rural schools in one of these countries (Mozambique). BMI was derived from objectively measured heights and weights. Moderate- to vigorous-intensity physical activity (MVPA), sedentary time (SED), and sleep duration were assessed by waist-worn Actigraph GT3X+ accelerometers. Linear models were used to describe the distributions of BMI z-scores, MVPA, SED, and …

Spatial And Pregnancy-Related Changes In The Protein, Amino Acid, And Carbohydrate Composition Of Bovine Oviduct Fluid, Beatriz Rodríguez-Alonso, Veronica Maillo, Omar Salvador Acuña, Rebeca López-Úbeda, Alejandro Torrecillas, Constantine A. Simintiras, Roger Sturmey, Manuel Avilés, Patrick Lonergan, Dimitrios Rizos

Faculty Publications

Knowledge of how the biochemical composition of the bovine oviduct is altered due to the oviduct anatomy or the presence of an embryo is lacking. Thus, the aim of this study was to assess the effect of (І) oviduct anatomy and (ІІ) embryo presence on oviductal fluid (OF) protein, amino acid, and carbohydrate composition. Cross-bred beef heifers (n = 19) were synchronized and those in standing estrus were randomly allocated to a cyclic (non-bred) or pregnant (artificially inseminated) group. All heifers were slaughtered on Day 3 after estrus. The oviducts ipsilateral to the corpus luteum from each animal were isolated, …

The 21st Century Agriculture: When Rice Research Draws Attention To Climate Variability And How Weedy Rice And Underutilized Grains Come In Handy, Noraikim Mohd Hanafiah, Muhamad Shakirin Mispan, Phaik Eem Lim, Niranjan Baisakh, Acga Cheng

Faculty Publications

Rice, the first crop to be fully sequenced and annotated in the mid-2000s, is an excellent model species for crop research due mainly to its relatively small genome and rich genetic diversity. The 130-million-year-old cereal came into the limelight in the 1960s when the semi-dwarfing gene sd-1, better known as the “green revolution” gene, resulted in the establishment of a high-yielding semi-dwarf variety IR8. Deemed as the miracle rice, IR8 saved millions of lives and revolutionized irrigated rice farming particularly in the tropics. The technology, however, spurred some unintended negative consequences, especially in prompting ubiquitous monoculture systems that increase agricultural …

Implementing Policy, Systems, And Environmental Change Through Community Coalitions And Extension Partnerships To Address Obesity In Rural Louisiana, Denise Holston, Jessica Stroope, Melissa Cater, Michelle Kendall, Stephanie Broyles

Faculty Publications

Community coalitions and agents funded by the Louisiana State University Agricultural Center's Healthy Communities program implemented multilevel obesity prevention interventions in 3 rural parishes (ie, counties) with an obesity prevalence of 40% or higher. The Healthy Communities coalitions appraised local health concerns through needs assessments and community forums. On the basis of local needs and the evidence base, the coalitions identified and implemented policy, systems, and environmental (PSE) strategies and supporting education to promote healthy behavior change among residents, overcoming barriers in the process. Interventions varied by parish but included Complete Streets implementation plans, healthy retail initiatives, play space improvements, …

Role Of Coastal Environmental Conditions During Austral Winter On Plankton Community Dynamics And The Occurrence Of Pseudo-Nitzschia Spp. And Domoic Acid In Inhambane Province, Mozambique, Holly Kelchner

LSU Master's Theses

Harmful algal blooms (HABs) are increasing globally in frequency, persistence, and geographic extent. HABs pose a threat to economic stability, and ecosystem and human health. To date no incidences of marine toxins produced by phytoplankton have been recorded in Mozambique, which may be due to the absence of a monitoring program and general awareness of the potential threat. This study is the first documentation of the occurrence of a neurotoxin, domoic acid (DA), produced by the diatom genus Pseudo-nitzschia spp. along the east coast of Africa. The coast of Inhambane Province is a biodiversity hotspot where year-round Rhincodon typus (whale …

A Randomized Controlled Trial To Reduce Sedentary Time In Rheumatoid Arthritis: Protocol And Rationale Of The Take A Stand For Health Study, Ana Jessica Pinto, Tiago Peçanha, Kamila Meireles, Fabiana Braga Benatti, Karina Bonfiglioli, Ana Lúcia De Sá Pinto, Fernanda Rodrigues Lima, Rosa Maria Rodrigues Pereira, Maria Claudia Costa Irigoyen, James Edward Turner, John P. Kirwan, Neville Owen, David W. Dunstan, Hamilton Roschel, Bruno Gualano

Division of Basic Science Faculty Publications

Background: Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods: The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive …

Mitochondrial Pyruvate Carriers Are Not Required For Adipogenesis But Are Regulated By High-Fat Feeding In Brown Adipose Tissue, Jasmine A. Burrell, Allison J. Richard, William T. King, Jacqueline M. Stephens

Faculty Publications

© 2020 The Obesity Society. Objective: The objectives of this study were to assess the role of mitochondrial pyruvate carriers (MPCs) in adipocyte development in vitro and determine whether MPCs are regulated in vivo by high-fat feeding in male and female C57BL/6J mice. Methods: This study utilized small interfering RNA-mediated knockdown to assess the requirement of MPC1 for adipogenesis in the 3T3-L1 model system. Treatment with UK-5099, a potent pharmacological MPC inhibitor, was also used to assess the loss of MPC activity. Western blot analysis was performed on adipose tissue samples from mice on a low-fat diet or a high-fat …

Review: Enhancing Intramuscular Fat Development Via Targeting Fibro-Adipogenic Progenitor Cells In Meat Animals, X. Li, X. Fu, G. Yang, M. Du

Faculty Publications

© 2019 The Animal Consortium. In the livestock industry, subcutaneous and visceral fat pads are considered as wastes, while intramuscular fat or marbling fat is essential for improving flavor and palatability of meat. Thus, strategies for optimizing fat deposition are needed. Intramuscular adipocytes provide sites for lipid deposition and marbling formation. In the present article, we addressed the origin and markers of intramuscular adipocyte progenitors-fibro-adipogenic progenitors (FAPs), as well as the latest progresses in mechanisms regulating the proliferation and differentiation of intramuscular FAPs. Finally, by targeting intramuscular FAPs, possible nutritional manipulations to improve marbling fat deposition are discussed. Despite recent …

Perinatal Maternal Antibiotic Exposure Augments Lung Injury In Offspring In Experimental Bronchopulmonary Dysplasia, Kent A. Willis, David T. Siefker, Michael M. Aziz, Catrina T. White, Naiha Mussarat, Charles K. Gomes, Amandeep Bajwa, Joseph F. Pierre, Stephania A. Cormier, Ajay J. Talati

Faculty Publications

Copyright © 2020 the American Physiological Society. During the newborn period, intestinal commensal bacteria influence pulmonary mucosal immunology via the gut-lung axis. Epidemiological studies have linked perinatal antibiotic exposure in human newborns to an increased risk for bronchopulmonary dysplasia, but whether this effect is mediated by the gut-lung axis is unknown. To explore antibiotic disruption of the newborn gut-lung axis, we studied how perinatal maternal antibiotic exposure influenced lung injury in a hyperoxia-based mouse model of bronchopulmonary dysplasia. We report that disruption of intestinal commensal colonization during the perinatal period promotes a more severe bronchopulmonary dysplasia phenotype characterized by increased …

Maternal Mtnr1b Genotype, Maternal Gestational Weight Gain, And Childhood Obesity, Zhaoxia Liang, Huikun Liu, Leishen Wang, Yuhang Chen, Tao Zhou, Yoriko Heianza, Weiqin Li, Junhong Leng, Jing Wang, Ru Gao, Gang Hu, Lu Qi

Population and Public Health Science Faculty Publications

Background: Maternal metabolic abnormalities have been related to offspring obesity especially during childhood. Objectives: We analyzed whether the gestational diabetes mellitus (GDM)-associated melatonin receptor 1B (MTNR1B) genotype of mothers modified the relation between maternal gestational weight gain and childhood obesity. Methods: A total of 1114 Chinese mother-child pairs (mothers with or without prior GDM) were included. Mothers' MTNR1B rs10830962 genotype and gestational weight gain were assessed. Indicators of childhood obesity included BMI-for-age z-score, weight-for-age z-score, waist circumference, and body fat. Childhood overweight and obesity were also analyzed. Results: We found that the maternal MTNR1B genotype significantly interacted with gestational weight …

Hot-Water Baths, Biologicals And Re-Curing Effects On Rhizopus Soft Rot During Sweetpotato Packing, R. R. Sweany, D. H. Picha, C. A. Clark

Faculty Publications

Rhizopus soft rot (RSR) caused by Rhizopus stolonifer is one of the most devastating postharvest diseases of sweetpotato. It causes greatest losses when sweetpotatoes are removed from storage, washed and packed for marketing. The disease has been managed effectively by prophylactic application of synthetic fungicides on the packing line. However, there is increasing demand for alternative management strategies that do not rely on prophylactic use of synthetic fungicides. While curing immediately after harvest is a standard industry practice, re-curing after storage is not widely practised for postharvest disease management. In this study, the use of hot-water baths, biocontrol agents and …

Maize Yield In Smallholder Agriculture System-An Approach Integrating Socioeconomic And Crop Management Factors, Sudarshan Dutta, Somsubhra Chakraborty, Rupak Goswami, Hirak Banerjee, Kaushik Majumdar, Bin Li, M. L. Jat

Faculty Publications

Yield gaps of maize (Zea mays L.) in the smallholder farms of eastern India are outcomes of a complex interplay of climatic variations, soil fertility gradients, socio-economic factors, and differential management intensities. Several machine learning approaches were used in this study to investigate the relative influences of multiple biophysical, socio-economic, and crop management features in determining maize yield variability using several machine learning approaches. Soil fertility status was assessed in 180 farms and paired with the surveyed data on maize yield, socio-economic conditions, and agronomic management. The C&RT relative variable importance plot identified farm size, total labor, soil factors, seed …

Trans-Disciplinary Responses To Climate Change: Lessons From Rice-Based Systems In Asia, Jon Hellin, Jean Balié, Eleanor Fisher, Ajay Kohli, Melanie Connor, Sudhir Yadav, Virender Kumar, Timothy J. Krupnik, Bjoern Ole Sander, Joshua Cobb, Katherine Nelson, Tri Setiyono, Ranjitha Puskur, Pauline Chivenge, Martin Gummert

Faculty Publications

Climate change will continue to have a largely detrimental impact on the agricultural sector worldwide because of predicted rising temperatures, variable rainfall, and an increase in extreme weather events. Reduced crop yields will lead to higher food prices and increased hardship for low income populations, especially in urban areas. Action on climate change is one of the Sustainable Development Goals (SDG 13) and is linked to the Paris Climate Agreement. The research challenge posed by climate change is so complex that a trans-disciplinary response is required, one that brings together researchers, practitioners, and policy-makers in networks where the lines between …

Prevalence And Correlates Of Objectively Measured Weight Status Among Urban And Rural Mozambican Primary Schoolchildren: A Cross-Sectional Study, Taru Manyanga, Joel D. Barnes, Jean Philippe Chaput, Lise Dubois, Peter T. Katzmarzyk, Emily F. Mire, Antonio Prista, Mark S. Tremblay

Population and Public Health Science Faculty Publications

Background The coexistence of undernutrition (thinness) and overnutrition (overweight/obesity) among children and adolescents is a public health concern in low-middle-income countries. Accurate prevalence estimates of thinness and overweight/obesity among children and adolescents are unavailable in many low-middle-income countries due to lack of data. Here we describe the prevalences and examine correlates of objectively measured weight status among urban and rural schoolchildren in Mozambique. Methods A cross-sectional study design was applied to recruit 9-11-year-old schoolchildren (n = 683) from 17 urban and rural primary schools in Mozambique. Body mass index (BMI) was computed from objectively measured height and weight and participants’ …

Body Composition During Pregnancy Differs By Obesity Class, Jasper Most, Abby D. Altazan, Daniel S. Hsia, Robbie A. Beyl, Leanne M. Redman

Clinical Research Faculty Publications

Objective: The aim of this study is to characterize changes in body composition during pregnancy in women with obesity. Methods: Fifty-four healthy women with obesity (class 1, 30-34.9 kg/m2: n = 25; class 2, 35-39.9 kg/m2: n = 21; class 3, ≥ 40.0 kg/m2: n = 8) expecting a singleton pregnancy were studied. Body composition was measured in early pregnancy (13-16 weeks), midpregnancy (24-27 weeks), and late pregnancy (35-37 weeks) using air displacement plethysmography, stable isotopes, and skinfold thickness measurements. Fasting glucose, insulin, and leptin were measured. Results: The gain in fat-free mass was lower in the second trimester compared …

Evaluation Of Ultraviolet (Uv-C) Light Treatment For Microbial Inactivation In Agricultural Waters With Different Levels Of Turbidity, Achyut Adhikari, Katheryn J. Parraga Estrada, Vijay S. Chhetri, Marlene Janes, Kathryn Fontenot, John C. Beaulieu

Faculty Publications

Produce growers using surface or well water to irrigate their crops may require an appropriate water treatment system in place to meet the water quality standard imposed by FSMA Produce Safety Rule. This study evaluated the potential of using ultraviolet (UV-C) treatment in reducing the microbial population in agricultural water. Waters with turbidity levels ranging from 10.93 to 23.32 Nephelometric Turbidity Units (NTU) were prepared by mixing pond water and well water. The waters were inoculated with a cocktail of generic Escherichia coli (ATCC 23716, 25922, and 11775) and then treated with UV-C light (20–60 mJ/cm2). All tested doses of …

Plumage Patterns: Ecological Functions, Evolutionary Origins, And Advances In Quantification, Nicholas A. Mason, Rauri C.K. Bowie

Faculty Publications

Birds exhibit remarkable variation in plumage patterns, both within individual feathers and among plumage patches. Differences in the size, shape, and location of pigments and structural colors comprise important visual signals involved in mate choice, social signaling, camouflage, and many other functions. While ornithologists have studied plumage patterns for centuries, recent technological advances in digital image acquisition and processing have transformed pattern quantification methods, enabling comprehensive, detailed datasets of pattern phenotypes that were heretofore inaccessible. In this review, we synthesize recent and classic studies of plumage patterns at different evolutionary and organismal scales and discuss the various roles that plumage …

Synthesis And Preliminary Ex Vivo Testing Of Sirna Targeting Tcrb: A Proposed Therapy For The Treatment Of Autoimmunity, Nicholas J. Magazine

LSU Doctoral Dissertations

Abstract

Background:

As of 2018, the United States National Institutes of Health estimate that over half a billion people worldwide are affected by autoimmune disorders. Though these conditions are prevalent, treatment options remain relatively poor, relying primarily on various forms of immunosuppression which carry potentially severe side effects and often lose effectiveness overtime. Given this, new forms of therapy are needed. We propose small-interfering RNA (siRNA) for hypervariable regions of the T-cell receptor β-chain gene (TCRb) as a highly targeted, novel means of therapy for the treatment of autoimmune disorders.

Objectives:

To develop methods to produce siRNA targeting …

Soil Health On A Small-Scale Sustainable Vegetable Farm In South Louisiana, Allison Guidroz

LSU Master's Theses

One of the biggest challenges facing the world today is the need to provide nutritious food to an ever-growing population in a way that does not compromise the ecosystem services of the soil that are necessary for life. The evidence for widespread degradation of the soil has been a major contributor in the increased interest in soil health. Most of the research in soil health has focused on field crops, which has led to a gap in the research of soil health on vegetable cropping systems. This objective of this study was to analyze the health of the soil on …

Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan

LSU Doctoral Dissertations

Substantial evidence shows that cellular heterogeneity commonly exists within an isogenic or clonal population. Whether in isolation or caused through a combination of the above events, cellular heterogeneity can dramatically influence cellular decision making and cell fate, however, this can be masked by the average response from a population. One approach to solve this issue is to analyze a population at the individual cell level. The goal of this work is to develop high-throughput experimental and computational platforms to screen and quantify single cancer cells for specific intracellular enzyme activities. An interdisciplinary approach was taken to 1) better understand the …

Sodium Propionate And Sodium Butyrate Promote Fatty Acid Oxidation In Hepg2 Cells Under Oxidative Stress, Kristina Jazmin Cook

LSU Doctoral Dissertations

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disturbances that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and liver cancer. NAFLD affects individuals that consume the typical Western diet consisting of high levels of fats and carbohydrates. The increase in circulating free fatty acids, palmitate and oleate, or lipopolysaccharides (LPS), induce oxidative stress and pro-inflammatory cytokine production in the liver, which all contribute to NAFLD progression. In this study, we are evaluating the mRNA expression of genes associated with fatty acid oxidation (FAO) and the protein expression of pro-inflammatory cytokines related to NAFLD using the HepG2 human liver …

A Role For Oncostatin M In The Impairment Of Glucose Homeostasis In Obesity, Irene Piquer-Garcia, Laura Campderros, Siri D. Taxerås, Aleix Gavaldà-Navarro, Rosario Pardo, María Vila, Silvia Pellitero, Eva Martínez, Jordi Tarascó, Pau Moreno, Joan Villarroya, Rubén Cereijo, Lorena González, Marjorie Reyes, Silvia Rodriguez-Fernández, Marta Vives-Pi, Carles Lerin, Carrie M. Elks, Jacqueline M. Stephens, Manel Puig-Domingo, Francesc Villarroya, Josep A. Villena, David Sánchez-Infantes

Faculty Publications

© 2019 Endocrine Society 2019. Context: Oncostatin M (OSM) plays a key role in inflammation, but its regulation and function during obesity is not fully understood. Objective: The aim of this study was to evaluate the relationship of OSM with the inflammatory state that leads to impaired glucose homeostasis in obesity. We also assessed whether OSM immunoneutralization could revert metabolic disturbances caused by a high-fat diet (HFD) in mice. Design: 28 patients with severe obesity were included and stratified into two groups: (1) glucose levels /dL and (2) glucose levels >100 mg/dL. White adipose tissue was obtained to examine OSM …

Soil Shear Strength Losses In Two Fresh Marshes With Variable Increases In N And P Loading, R. Eugene Turner, Christopher Swarzenski, James E. Bodker

Faculty Publications

We measured soil shear strength (SSS) from 2009 to 2018 in two hydrologically distinct freshwater marshes dominated by Panicum hemitomon after nitrogen (N) and phosphorous (P) were applied to the surface in spring. The SSS averaged over 100-cm depth in the floating and anchored marshes declined up to 30% throughout the profiles and with no apparent differences in the effects of the low, medium, and high N + P dosing. Plots with only N or P additions exhibited significant changes in SSS at individual depths below 40 cm for the anchored marsh, but not the floating marsh. The average SSS …

Improving Natural Product Research Translation: From Source To Clinical Trial, Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. Macmillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D.R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli

Faculty Publications

© 2019 Federation of American Societies for Experimental Biology While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety and efficacy, CTs, especially phase III CTs, are costly and require rigorous planning to optimize the value of the information obtained. More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop. Participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, …

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

Tropism, Pathology, And Transmission Of Equine Parvovirus-Hepatitis, Joy Ellen Tomlinson, Mason Jager, Alyssa Struzyna, Melissa Laverack, Lisa Ann Fortier, Edward Dubovi, Lane D. Foil, Peter D. Burbelo, Thomas J. Divers, Gerlinde R. Van De Walle

Faculty Publications

© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotropism by PCR on tissues from acutely infected horses. We then experimentally inoculated horses with EqPV-H and 8 of 10 horses developed hepatitis. One horse showed clinical signs of liver failure. The onset of hepatitis was temporally associated with seroconversion and …

Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland

Faculty Publications

© Lippincott Williams & Wilkins. Purpose Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways. Methods Lean, healthy male C57BL/6J mice were fed a low-fat control diet (15.9% kcal protein, 11.9% kcal fat, 72.2% kcal …

Safety And Pharmacokinetics Of Naringenin: A Randomized, Controlled, Single-Ascending-Dose Clinical Trial, Candida J. Rebello, Robbie A. Beyl, Juan J.L. Lertora, Frank L. Greenway, Eric Ravussin, David M. Ribnicky, Alexander Poulev, Brandon J. Kennedy, Hector F. Castro, Shawn R. Campagna, Ann A. Coulter, Leanne M. Redman

Clinical Research Faculty Publications

Aims: To evaluate the safety and pharmacokinetics of naringenin in healthy adults consuming whole-orange (Citrus sinensis) extract. Methods and methods: In a single-ascending-dose randomized crossover trial, 18 adults ingested doses of 150 mg (NAR150), 300 mg (NAR300), 600 mg (NAR600) and 900 mg (NAR900) naringenin or placebo. Each dose or placebo was followed by a wash-out period of at least 1 week. Blood safety markers were evaluated pre-dose and 24 hours post-dose. Adverse events (AEs) were recorded. Serum naringenin concentrations were measured before and over 24 hours following ingestion of placebo, NAR150 and NAR600. Four- and 24-hour serum measurements were …