Digital Commons Network^™

Method For Assessing Coating Uniformity Of Angioplasty Balloons Coated With Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded With Quercetin, Allison D. Zieschang, Kevin F. Hoffseth, Tammy R. Dugas, Carlos E. Astete, Dorin Boldor

Faculty Publications

In this study, we aim to quantify coating uniformity and correlate fluorescence intensity to drug loading for drug-coated angioplasty balloons (DCB) coated with 5, 10, 15, or 20 layers of poly(lactic-co-glycolic acid) nanoparticles (NPs) entrapped with quercetin. Uniformity was quantified from histograms and horizontal line profiles of microscopic fluorescent images acquired with sample specific parameters, and cracks in the coating were measured and counted. The fluorescence of images acquired with global parameters was correlated with quercetin loading measured via gravimetric/HPLC analysis. More layers on DCBs may be associated with less uniform coatings, as indicated by differences in histogram standard deviations. …

Vehicle Classification Technologies For Toll Collection, Samir Ahmed

Publications

Toll facilities (roads, bridges, and tunnels) are intended for revenue generation to pay off the long-term debt issued to finance construction, capacity expansion, operations, and maintenance of these facilities. Tolls are one form of a broad concept known as road pricing. In addition to revenue generation, road pricing is used for other reasons including transportation demand management to reduce peak hour travel and the recurring traffic congestion on some corridors. The aim of this study is to provide the tolling industry with detailed analysis of the suitability of various non‐ pavement‐intrusive vehicle classification technologies (imaging using radar, Lidar, thermal profiling, …

Framework Of Internal Damage Identification In Inhomogeneous Medium Interweaving Wave Scattering Model And Deep Learning, Suyun Ham, Stefan Romanoschi, Yin Chao Wu, Dafnik Saril Kumar David

Publications

The primary objective of this project is to investigate the framework of internal damage identification in inhomogeneous media (IHM) using deep learning techniques and wave scattering. The study focuses on two main steps: 1) analyzing the wave response pattern in homogeneous media (HM) and 2) characterizing the wave response variation (WRV) in IHM with different aggregate sizes and random distributions. The WRV patterns are then classified and used to predict internal damage using a convolutional neural network (CNN). The accuracy of the finite element (FE) model is verified using laboratory tests with artificial internal crack models of varying depths. The …

Automated Vehicle Impacts On Underserved Populations, Kate Kyung Hyun, Stephen Mattingly, Katie Kam

Publications

This research report describes the scenario framework created to determine the potential role automated vehicles (AVs) have in benefiting and adversely impacting the following underserved populations: people with disabilities and impairments (visually, hearing, physically, intellectually) and with autism spectrum disorder, younger and older populations, immigrants, low income, indigenous, rural, female and LGBTQ+, vulnerable road users (cyclists, pedestrians, low speed riders and drivers), and minority races. After presenting a literature review, three chapters explain the 3 modules of the framework: (1) scenario construction, (2) scenario factors, and (3) GIS methodology for evaluating community level AV impacts. Module 1 describes the use …

Motorcycle Crash Analysis, Hatim Sharif, Samer Dessouky

Publications

The Fatality Analysis Reporting System database shows that, in stark contrast to the 34 percent decline in non-motorcyclist crash–related fatalities, motorcyclist crash–related fatalities were up 86 percent with only three year-to-year declines since 1997, while non-motorcyclist crash–related fatalities had 13 year-to-year declines since 1997. At the national level, the rate of motorcyclist fatalities per vehicle mile traveled is 29 times higher than the rate among passenger car occupants, with overall injury rates approximately five times higher among motorcyclists than passenger car occupants. Given the frequency of motorcycle crashes and their staggering toll in terms of loss of life and economic …

Error In Weighted Analyses And Reported Prevalence Rates, Amanda E. Staiano

Population and Public Health Science Faculty Publications

No abstract provided.

A 30-Year Dataset Of Co2 In Flowing Freshwaters In The United States, Timothy R. Toavs, Caleb T. Hasler, Cory D. Suski, Stephen R. Midway

Faculty Publications

Increasing atmospheric carbon dioxide (CO2) concentrations have been linked to effects in a wide range of ecosystems and organisms, with negative effects of elevated CO2 documented for marine organisms. Less is known about the dynamics of CO2 in freshwaters, but the potential exists for freshwater organisms to be challenged by elevated CO2. In flowing freshwaters CO2 exhibits more variability than in lakes or the ocean, yet spatiotemporally extensive direct measures of CO2 in freshwater are rare. However, CO2 can be estimated from pH, temperature, and alkalinity—commonly collected water quality metrics. We used data from the National Water Quality Monitoring Council …

A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel

Faculty Publications

Mosquitoes are a known public nuisance and can vector various diseases. Historically, New Orleans, LA, has long been acquainted with the burden of mosquito-borne diseases, such as malaria and yellow fever in the 20th century and West Nile virus in the 21st century. Government mosquito control awareness campaigns have been around for decades as has the use of organophosphate and pyrethroid insecticides by mosquito abatement districts. However, few data are available on public perception of mosquito control and public usage of insecticides to kill mosquitoes in New Orleans. We conducted a survey from August 2020 to July 2021 to evaluate …

Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan

Faculty Publications

In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the “more is better” paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. To accommodate this paradigm shifting, we propose a dose-ranging approach to optimizing dose (DROID) for oncology trials with targeted drugs. DROID leverages the well-established dose-ranging study framework, which has been routinely used to develop non-oncology drugs for decades, and bridges it with established oncology dose-finding designs to …

Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky

Faculty Publications

Introduction: Cigarette smoking remains the leading preventable cause of death and disability in the United States and frequently co-occurs with anxiety and depressive symptoms. A novel and integrative, theory-driven approach to address the heterogeneity of mood-related symptoms associated with cigarette use is to focus on transdiagnostic processes, such as distress tolerance, that underpin both mood-related symptoms and smoking behavior. The current study sought to develop and examine the feasibility, acceptability, and initial efficacy of a digitally delivered integrated personalized feedback intervention (PFI) that addresses smoking-distress tolerance relations. Methods: Participants included 121 adults (71.1 % male; Mage = 29.33 years, SD …

Effect Of An Acute Long-Duration Exercise Bout On Skeletal Muscle Lipid Droplet Morphology, Glut 4 Protein, And Perilipin Protein Expression, Sudip Bajpeyi, Jehu N. Apaflo, Victoria Rosas, Keisha Sepulveda-Rivera, Armando Varela-Ramirez, Jeffrey D. Covington, Jose E. Galgani, Eric Ravussin

Clinical Research Faculty Publications

Purpose: Smaller lipid droplet morphology and GLUT 4 protein expression have been associated with greater muscle oxidative capacity and glucose uptake, respectively. The main purpose of this study was to determine the effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT4, perilipin 3, and perilipin 5 expressions. Methods: Twenty healthy men (age 24.0 ± 1.0 years, BMI 23.6 ± 0.4 kg/m2) were recruited for the study. The participants were subjected to an acute bout of exercise on a cycle ergometer at 50% VO2max until they reached a total energy expenditure of 650 kcal. The study …

Body Shape Perception In Men And Women Without Obesity During Caloric Restriction: A Secondary Analysis From The Calerie Study, Maci M. Jacobson, Alexis M. Gardner, Camilla E. Handley, Michael W. Smith, William F. Christensen, Chad R. Hancock, Paule V. Joseph, Michael J. Larson, Corby K. Martin, James D. Lecheminant

Clinical Research Faculty Publications

Objective: To examine body shape perception in 218 adults without obesity or history of eating disorders during caloric restriction (CR). Methods: Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) is a 2-year, randomized clinical trial using a 2:1 assignment (CR, 25% reduction in calories; Control, typical diet). For this secondary analysis, we examined perceived body shape using the Body Shape Questionnaire (BSQ). Analyses of BSQ scores are reported by group, over time, by sex, and by BMI. Data for body fat percentage, symptoms of depression, food cravings, maximal oxygen consumption, and stress were analyzed for their association …

Acute Exercise Increases Nk Cell Mitochondrial Respiration And Cytotoxicity Against Triple-Negative Breast Cancer Cells Under Hypoxic Conditions, Eunhan Cho, James Stampley, Rachel Wall, Rachel Matthews, Elizabeth Zunica, Justin C. Brown, Neil M. Johannsen, Brian A. Irving, Guillaume Spielmann

Clinical Research Faculty Publications

Purpose Triple-negative breast cancer (TNBC) is an aggressive, highly metastatic malignancy with high recurrence rates. Hypoxia is a hallmark of the TNBC tumor microenvironment, which promotes tumor growth while impairing natural killer (NK) cell cytotoxic functions. Although acute exercise improves NK cell function under normoxic conditions, the effect of exercise on NK cell cytotoxic functions under hypoxic conditions mimicking O2 tensions observed in solid tumors is unknown. Methods The cytotoxic functions of resting and postexercise NK cells isolated from thirteen young inactive healthy women were assessed against breast cancer cells expressing different levels of hormone receptors (MCF-7 and MDA-MB-231) under …

An Aerobic Exercise Intervention To Improve Metabolic Health Among People Living With Hiv With At-Risk Alcohol Use: The Alive-Ex Research Study Protocol, Liz Simon, Stefany D. Primeaux, Danielle E. Levitt, Brianna Bourgeois, Neil M. Johannsen, Adrianna Peters, Jameel Ahmed, Richard H. Marshall, Alexandra H. Fairchild, Tekeda F. Ferguson, Patricia E. Molina

Clinical Research Faculty Publications

Background: Effective antiretroviral therapy (ART) in people living with HIV (PLWH) has improved life expectancy and increased risk of age-associated cardiometabolic comorbidities. At-risk alcohol use is more frequent among PLWH and increases the risk of health challenges. PLWH with at-risk alcohol use are more likely to meet criteria for prediabetes/diabetes and this is associated with impaired whole-body glucose-insulin dynamics. Methods: The Alcohol & Metabolic Comorbidities in PLWH: Evidence Driven Interventions Study (ALIVE-Ex Study, NCT03299205) is a longitudinal, prospective, interventional study to determine the effects of an aerobic exercise protocol on improving dysglycemia among PLWH with at-risk alcohol use. The intervention …

An Examination Of The Relationships Between The Neighborhood Social Environment, Adiposity, And Cardiometabolic Disease Risk In Adolescence: A Cross-Sectional Study, Kara D. Denstel, Robbie A. Beyl, Denise M. Danos, Maura M. Kepper, Amanda E. Staiano, Katherine T. Theall, Tung Sung Tseng, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

Background: Disadvantaged neighborhood environments are a source of chronic stress which undermines optimal adolescent health. This study investigated relationships between the neighborhood social environment, specifically, chronic stress exposures, adiposity, and cardiometabolic disease risk factors among 288 Louisiana adolescents aged 10 to 16 years. Methods: This cross-sectional study utilized baseline data from the Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) study. Adolescent data were obtained using self-reported questionnaires (demographics and perceived neighborhood disorder), anthropometry, body imaging, and a blood draw while objective neighborhood data for the concentrated disadvantage index were acquired from the 2016 American Community Survey …

Adolescent Diet Quality, Cardiometabolic Risk, And Adiposity: A Prospective Cohort, Kathy Hu, Alyssa M. Button, Claire M. Tate, Chelsea L. Kracht, Catherine M. Champagne, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Objective: Examine the prospective association among diet with adolescent cardiometabolic risk (CMR) and anthropometrics. Methods: Secondary analysis of an observational study of adolescents aged 10–16 years. Twenty-four-hour food recalls were used to calculate Healthy Eating Index-2015 (HEI-2015) scores. Anthropometrics were assessed using magnetic resonance imaging, dual-energy x-ray absorptiometry, and height/weight measurements. CMR included mean arterial pressure, homeostatic model assessment for insulin resistance, high-density lipoprotein cholesterol, and triglycerides. Associations between HEI-2015 score at baseline with follow-up adiposity and CMR were examined using regression models. Results: A total of 192 adolescents were included. Baseline HEI-2015 scores were inversely associated with follow-up total …

Amplifying Support For Physical Activity: The National Strategy On Hunger, Nutrition, And Health, Peter T. Katzmarzyk, John M. Jakicic, Russell R. Pate, Katrina L. Piercy, Laurie P. Whitsel

Population and Public Health Science Faculty Publications

No abstract provided.

Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo

Faculty Publications

Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased …

The Longitudinal Associations Of Body Dissatisfaction With Health And Wellness Behaviors In Midlife And Older Women, Lisa Smith Kilpela, Savannah C. Hooper, Casey L. Straud, Victoria B. Marshall, Christina L. Verzijl, Tiffany M. Stewart, Taylur T. Loera, Carolyn Black Becker

Population and Public Health Science Faculty Publications

Emerging research suggests that body dissatisfaction (BD) is prevalent among midlife and older women (i.e., upwards of 70%). Cross-sectionally, BD is associated with myriad poor health and wellness outcomes (e.g., depression, disordered eating, bad nutrition) in midlife/older women. However, relatively few studies have examined the longitudinal relations between BD and health outcomes in this population. This preliminary study investigated the longitudinal associations of BD with wellbeing and health-related quality of life (QOL) among midlife/older adult women over one year. Participants (n = 86, women aged 40–72 years, M = 51.49, SD = 7.34, 86% white) completed self-report measures of BD, …

Digital Archives: How Western Newspapers Frame Our Remembrance Of The Gezi Park Protest, Nihar Sreepada, Ahmet Aksoy

Faculty Publications

We analyze the coverage of the Gezi Park protests by two major Western newspapers - The New York Times and The Guardian - through the lens of media framing, rhetoric, and collective memory. We argue that these digital archives frame Turkey's Gezi Park protests as a challenge to an authoritarian government by promoting the themes of unrest as a conflict of ideologies, oppression of citizens, and the park as a site of memory. In a concluding section, we focus on the significance of digital archives as repositories of collective memory and the role of media framing in shaping these reconstructions …

Examining Consumers’ Perceptions Of And Attitudes Toward Digital Fashion In General And Purchase Intention Of Luxury Brands’ Digital Fashion Specifically, Yanbo Zhang, Chuanlan Liu, Yanru Lyu

Faculty Publications

Digital fashion may instill transformative power into the fashion industry as it can simultaneously deliver fashionability and sustainability. Renowned for their innovativeness and creativity, luxury brands embrace digital fashion and achieve market success, indicating the future of digital fashion. This research aims to empirically investigate consumers’ general perceptions and evaluations of digital fashion and to specifically examine consumers’ purchase intention of luxury brands’ digital fashion. A total of 214 responses were collected from a U.S.-based research company’s consumer panel. Data were analyzed by using structural equation modeling (SEM). The results revealed that the general attitude toward digital fashion is influenced …

Sediment Delivery To Sustain The Ganges-Brahmaputra Delta Under Climate Change And Anthropogenic Impacts, Jessica L. Raff, Steven L. Goodbred, Jennifer L. Pickering, Ryan S. Sincavage, John C. Ayers, Md Saddam Hossain, Carol A. Wilson, Chris Paola, Michael S. Steckler, Dhiman R. Mondal, Jean Louis Grimaud, Celine Jo Grall, Kimberly G. Rogers, Kazi Matin Ahmed, Syed Humayun Akhter, Brandee N. Carlson, Elizabeth L. Chamberlain, Meagan Dejter, Jonathan M. Gilligan, Richard P. Hale, Mahfuzur R. Khan, Md Golam Muktadir, Md Munsur Rahman, Lauren A. Williams

Faculty Publications

The principal nature-based solution for offsetting relative sea-level rise in the Ganges-Brahmaputra delta is the unabated delivery, dispersal, and deposition of the rivers’ ~1 billion-tonne annual sediment load. Recent hydrological transport modeling suggests that strengthening monsoon precipitation in the 21st century could increase this sediment delivery 34-60%; yet other studies demonstrate that sediment could decline 15-80% if planned dams and river diversions are fully implemented. We validate these modeled ranges by developing a comprehensive field-based sediment budget that quantifies the supply of Ganges-Brahmaputra river sediment under varying Holocene climate conditions. Our data reveal natural responses in sediment supply comparable to …

Give Me A Break, Oil Companies Don’T Need Them: A Case Study Of Drilling Incentives In Louisiana Oil & Gas, Samuel Camacho

Honors Capstones

No abstract provided.

The Gender Gap: A Comparative Analysis Of Male And Female Rape Victims, Emma Carlo

Honors Capstones

No abstract provided.

Performative Mixing For Immersive Audio, Brian A. Elizondo

LSU Doctoral Dissertations

Immersive multichannel audio can be produced with specialized setups of loudspeakers, often surrounding the audience. These setups can feature as few as four loudspeakers or more than 300. Performative mixing in these environments requires a bespoke solution offering intuitive gestural control. Beyond the usual faders for gain control, advancements in multichannel sound demand interfaces capable of quickly positioning sounds between channels. The Quad Cartesian Positioner is such a solution in the form of a Eurorack module for surround mixing for use in live or studio performances.

Diffusion/mixing methods for live multichannel immersive music often rely on the repurposing of hardware …

An Intersection Of Science & Art: Vitrification Approaches And Open-Fabricated Tools For The Biomedical Model Sea Hare, Aplysia Californica, Allyssa M. Oune

LSU Master's Theses

The California sea hare (Aplysia californica) is an important biomedical model for molecular neurobiology, electrophysiology, learning, and memory due to their well-mapped and large neurons and well-characterized learning capabilities. The National Resource for Aplysia (NRA, University of Miami) maintains large stocks of live animals and relies on regular shipments of wild-caught individuals to maintain genetic diversity. This is labor and cost-intensive, and environmental changes could alter the availability of wild animals increasing the need to preserve this genetic resource. One solution is vitrification, ultra-fast cooling which produces an amorphous glass that minimizes damage to cells. Aplysia californica presents …

Improving Cellphone-Based Bio-Imaging Technique For Fluorescence Detection, Erteza T. Efaz

LSU Master's Theses

The research presented in this thesis focuses on the design, development, and evaluation of a fluorescence detection system. The system is implemented primarily as an Android application, Auto Camera, which leverages smartphone cameras to capture and analyze fluorescent images. The application provides a user-friendly interface with some configurable features like exposure time, ISO speed, and storage limit; as well as defining detection thresholds and setting acquisition intervals. This study begins with the architectural framework of the Android application, which is written in Java using Android Studio. The API compatibility is set to version 33, and users are prompted to grant …

Microfluidic Isolation Of Tumor Cells Or Other Rare Cells From Whole Blood Or Other Liquids, Steven A. Soper, Michael C. Murphy, Juan Feng, Robin L. Mccarley, Andre A. Adams

College of Science Patents

No abstract provided.

A Study Of Tissue-Specific Rho Signaling Activation During Tubular Organ Formation In Drosophila, Charlotte Jean-Louise Adams

LSU Master's Theses

Several organs within the human body are tubular in structure. In the event of a malfunction in the development of these tubular structures, maladies like spina bifida, anencephaly, and several other defects can arise. To understand the mechanisms of tubular organ formation, we use the Drosophila embryonic salivary gland (SG) as a model. During embryogenesis, SG cells undergo a series of cell shape changes, like apical constriction, to accommodate the developing gland. Apical constriction is regulated in part by the signal of the secreted ligand Folded gastrulation (Fog) and its G protein-coupled receptor (GPCR) at the cell membrane, which leads …

Mirna As Systemic Mediators For Environmentally Persistent Free Radical-Induced Cardiovascular Dysfunction, Ankit Aryal

LSU Doctoral Dissertations

Air pollution is consistently linked with elevations in cardiovascular disease (CVD) and its mortality. Particulate matter (PM) is a pivotal factor in air pollution-associated CVD. PM containing environmentally persistent free radicals (EPFR) forms from the incomplete combustion of organic wastes. These products adhere to particulate matter carrying redox-active transition metals on its surface. To enable systematic research of the health impacts of EPFR, our colleagues developed a combustion method to produce EPFR-containing PM that closely resemble urban PM and validated their use for typical laboratory settings. We exposed mice to laboratory generated EPFR through whole-body inhalation and investigated their dose-dependent …