Digital Commons Network^™

Gna13 Suppresses Proliferation Of Er+ Breast Cancer Cells Via Erα Dependent Upregulation Of The Myc Oncogene, Lalitha Vaishnavi Subramanyan, Suhail Ahmed Kabeer Rasheed, Lijin Wang, Sujoy Ghosh, Michelle Shi Ning Ong, Manikandan Lakshmanan, Mei Wang, Patrick J. Casey

Division of Basic Science Faculty Publications

GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to be essential for embryonic development and vasculogenesis and has been increasingly shown to be involved in mediating several steps of cancer progression. Recent studies found that Gα13 can function as an oncogene and contributes to progression and metastasis of multiple tumor types, including ovarian, head and neck and prostate cancers. In most cases, Gα12 and Gα13, as closely related α-subunits in the subfamily, have similar cellular roles. However, in recent years their differences in …

Information Sources And Vaccination In The Covid-19 Pandemic, Nana Osei Asiamah, Paige B. Miller, Xiaoxu Yang, Wesley Shrum

Faculty Publications

Among the issues that remained contentious throughout the pandemic was vaccination: its efficacy, side effects, and the general reluctance of a substantial segment of the population to get vaccinated. The aim of this paper is to understand the role of health information sources in anti-vaccination sentiment and the decision to vaccinate. Regression models were used to analyze data from an online survey of adults in the United States in late 2021 (n = 10,221). The results of the study showed that: (a) information from local and national health experts had a significant positive association with getting the COVID-19 vaccine and …

Children’S Individual Differences In The Responses To A New Method For Physical Education, Sara Pereira, Carla Santos, José Maia, Olga Vasconcelos, Eduardo Guimarães, Rui Garganta, Cláudio Farias, Tiago V. Barreira, Go Tani, Peter T. Katzmarzyk, Fernando Garbeloto

Population and Public Health Science Faculty Publications

Children’s fundamental movement skills (FMS) require planned and guided interventions to develop appropriately. We investigated the effect of a novel Physical Education (PE) method to develop children’s object control, locomotor skills, and motor competence. Further, we examined children’s trainability, i.e., their differential responses to the new method, and identified low and high responders to the intervention. The study lasted three months and included six to seven-year-old children in two groups: control (the current, official PE program; n = 38) and experimental (the new method; n = 52). Twelve FMS [object control (OC), locomotor (LO)] were reliably assessed using the Meu …

Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Klasson, I. M. Lima, J. L. Purswell, M. Souliman, E. Terrell, B. S. Tubaña, H. L. Waguespack, J. J. Wang, P. M. White

Faculty Publications

Abstract: Sugarcane (Saccharum officinarum) is Louisiana's number one row crop. Growing and processing sugarcane produces significant amounts of byproducts, including bagasse, crop residue, molasses, filter-press mud, and boiler fly ash. These products represent an important opportunity to generate value-added and specialty products and enhance sugarcane's sustainability by facilitating a circular economy, where agricultural by-products are reused instead of disposing them (linear economy), in order to reduce resource use and energy demand. Examples of value-added products range from biochar, construction materials, animal feed, biofuels, nanoparticles, and fertilizer. Paramount to the success of the bio-based circular economy is creating useful products that …

Research Overview On Urban Heat Islands Driven By Computational Intelligence, Chao Liu, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Wenfeng Zheng

Faculty Publications

In recent years, the intensification of the urban heat island (UHI) effect has become a significant concern as urbanization accelerates. This survey comprehensively explores the current status of surface UHI research, emphasizing the role of land use and land cover changes (LULC) in urban environments. We conducted a systematic review of 8260 journal articles from the Web of Science database, employing bibliometric analysis and keyword co-occurrence analysis using CiteSpace to identify research hotspots and trends. Our investigation reveals that vegetation cover and land use types are the two most critical factors influencing UHI intensity. We analyze various computational intelligence techniques, …

Gleaning Rural Journalism: Rural Journalists' Agricultural And Environmental Reporting Utilizing Community Storytelling Networks☆, Jessica Walsh, Mildred F. Perreault, Greg Perreault, Ruth Moon

Faculty Publications

Environmental concerns are growing in parts of the rural United States as drinking water wells become contaminated with agrichemicals, and climate change impacts such as drought and extreme rain events disrupt farming practices. Analyzing in-depth interviews with 29 U.S. rural journalists, we explore the role rural journalists play when reporting on the environment as it relates to agricultural issues. Findings show that reporting about the environment—such as weather, climate change, water shortages, and droughts—appear in rural journalists' stories given those topics' relevance to their rural communities and the social systems forces exerting influence on journalists, yet rural journalists often do …

International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li

Clinical Research Faculty Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy with significant reproductive, metabolic, and psychological complications. Consensus on PCOS clinical research priorities across end-users is fundamental and necessitates a robust co-development of a clinical research roadmap to guide international research efforts. Methods: A multistage process included: i) international surveys of women and healthcare providers to identify research priorities and unmet needs; ii) interrogation of systematic reviews conducted for the International PCOS Guideline to identify research gaps; iii) International PCOS Guideline Network consensus generated clinical research roadmap; and iv) international peer review for external validation. Findings: A codesigned survey engaging 1278 …

Investigating The Role That Calcium And The Membrane Play In 8r-Lipoxygenase Catalysis, Kaelie Bernard

Honors Capstones

No abstract provided.

Cryo-Em Structure Of A Photosystem I Variant Containing An Unusual Plastoquinone Derivative In Its Electron Transfer Chain, Christopher J. Gisriel, Vasily Kurashov, David F. Iwig, Brandon P. Russell, David J. Vinyard, Gary W. Brudvig, John H. Golbeck, K. V. Lakshmi

Faculty Publications

Photosystem I (PS I) is a light-driven oxidoreductase responsible for converting photons into chemical bond energy. Its application for renewable energy was revolutionized by the creation of the MenB deletion (ΔmenB) variant in the cyanobacterium Synechocystis sp. PCC 6803, in which phylloquinone is replaced by plastoquinone-9 with a low binding affinity. This permits its exchange with exogenous quinones covalently coupled to dihydrogen catalysts that bind with high affinity, thereby converting PS I into a stable solar fuel catalyst. Here, we reveal the 2.03-Å-resolution cryo-EM structure of a recent MenB variant of PS I. The quinones and their binding environment are …

Understanding Mechanisms For Coastal Marsh Sustainability In A Changing Climate, Ashley R. Booth

LSU Doctoral Dissertations

In the Chenier Plain of Louisiana and Texas, coastal marshes are subject to high rates of relative sea level rise (RSLR), restricted sedimentation, and declining elevation attributed to subsidence and decades of intensive management. These marshes were created via mineral sedimentation but now largely accrete via organic matter accumulation. This organic matter accumulation (OMA) – or the balance between plant productivity and decomposition – is essential for maintaining elevation and thus long-term sustainability. However, management for elevation is complicated by a poor understanding of how abiotic factors like flooding and salinity impact processes driving OMA and elevation. To better understand …

Forensicllm: A Local Large Language Model For Digital Forensics, Binaya Sharma

LSU Master's Theses

Large Language Models (LLMs) excel in diverse natural language tasks but often lack specialization in fields like digital forensics. Their reliance on cloud-based APIs or high-performance computers restricts their use in resource-limited environments, and response hallucinations could compromise their applicability in forensic contexts. We introduce ForensicLLM, a 4-bit quantized LLaMA-3.1-8B model fine-tuned using Retrieval Augmented Fine-tuning (RAFT) on 6,739 Q&A samples extracted from 1,082 digital forensic research articles and curated digital artifacts. Evaluation on 2,244 Q&A samples showed that ForensicLLM outperformed the base LLaMA-3.1-8B model by 4.06%, 5.43%, and 15.79% on BERTScore F1, BGE-M3 cosine similarity, and G-Eval, respectively. Compared …

Evaluating Growth Of Coastal Grass In Recycled Glass Sand: Evidence For Safe Application In Coastal Restoration, Allison B. Huddleston

Honors Capstones

Louisiana’s coastal land loss results from complex interactions of anthropogenic and naturally occurring processes that impact sediment supply in the Mississippi river delta. Given the coastline's vital role in the state’s economy, Louisiana has made significant investments in coastal restoration projects, including planting native vegetation and adding borrowed sediments. The amount of sediment needed to maintain Louisiana’s existing coastline exceeds the available amount that could be extracted, and state officials have since identified this lack of sustainable sediment resources as a critical limitation for future restoration projects. One proposed solution to address this shortage is using recycled crushed glass cullet …

De La Saleté A La Poésie : Portrait De La France Périphérique Dans L’Été Des Charognes De Simon Johannin, Julie Catel

Tête à Tête: Journal of Francophone Studies

Simon Johannin's debut novel, "L'Été des charognes," published in 2017, offers a vivid portrayal of life in La Fourrière, an isolated village located in the Vosges. This area falls within what the French sociologist Christophe Guilluy terms 'France périphérique,' which refers to rural regions plagued by poverty and a sense of neglect. Through the perspective of an adolescent narrator, Johannin depicts the village's harsh daily reality, emphasizing its pervasive violence and the filth that characterizes its landscape. The narrative is saturated with descriptions of unpleasant odors, particularly from the decomposing carcasses of farm animals awaiting disposal, which permeate the village …

Pooled Analysis Of Physical Activity, Sedentary Behavior, And Sleep Among Children From 33 Countries, Kar Hau Chong, Thomas Suesse, Penny L. Cross, Sarah T. Ryan, Eivind Aadland, Oluwayomi Aoko, Ankhmaa Byambaa, Valerie Carson, Jean Philippe Chaput, Hayley Christian, Dylan P. Cliff, Marieke De Craemer, Clarice Maria De Lucena Martins, Christine Delisle Nyström, Catherine E. Draper, Asmaa El Hamdouchi, Alex Antonio Florindo, Hongyan Guan, Amy S. Ha, Najmeh Hamzavi Zarghani, Kylie D. Hesketh, Mohammad Sorowar Hossain, Jajat Jajat, Thanh Kim, Denise Koh, Anna V. Kontsevaya, Nicholas Kuzik, Marja H. Leppänen, Marie Löf, Himangi Lubree, Kim Meredith-Jones, Tawonga W. Mwase-Vuma, Johan Y.Y. Ng, Rachel Novotny

Population and Public Health Science Faculty Publications

Importance: The prevalence estimates of physical activity, sedentary behavior, and sleep (collectively known as movement behaviors) in 3-and 4-year-old children worldwide remains uncertain. Objective: To report the proportion of 3-and 4-year-old children who met the World Health Organization guidelines for physical activity, sedentary behavior, and sleep across 33 countries. Design, Setting, and Participants: Pooled analysis of data from 14 cross-sectional studies (July 2008 to September 2022) identified through systematic reviews and personal networks. Thirty-Three countries of varying income levels across 6 geographical regions. Each study site needed to have at least 40 children aged 3.0 to 4.9 years with valid …

Euphemism In Ai Discourse As Colonial Harm & Effect: Learnings From Subaltern Puerto Rico, Jacqueline Oquendo

LSU Doctoral Dissertations

Through three integrated studies, this dissertation explores complex human-AI interactions by comparing the perceptions of two groups of U.S. citizens: subaltern Puerto Ricans and stateside Americans’ interactions with ChatGPT. This corpus-assisted Critical Discourse Analysis or CLCDA, triangulated with 1:1 semi-structured interviews, validates scholars’ concerns about the biases inherent in generative AI. Contributing to those concerns, this dissertation reveals that ChatGPT deploys discourse strategies that, when executed, facilitate digital colonialism. Euphemistic language is prominent among its discourse strategies, replacing controversial words, phrases, and topics with more palatable ones. When prompted on events of historical significance, I find that ChatGPT’s discourse obscures …

Mapping Gender And Territory: The Continent Allegories On European World Maps From The Late Middle Ages To The Renaissance Until The Early Enlightenment, Katharina Eva Oehmichen

Comparative Woman

The four-part set of female continent allegories, which originated in the early Renaissance, was born out of a European need for a new vehicle of thought that served the functions of representing imperial expansion and the superiority of Western science and civilization, while gratifying the curiosity of the readers about newly discovered lands at the same time. The shift from the Christian symbolic tradition of the representation of the continents on world maps mirrored the shift in Western perception and knowledge of the world and Europe’s position in it. Apart from geo-political and imperial agendas that might have favored a …

Living Losses, Courtney A. Brown Phd

Comparative Woman

Contextually, I am from a line of strong black women. I am from a community of strivers and survivors who’ve accomplished great things through the blanket of patriarchy and civil injustices. I stand on the shoulders of many who took literal and figurative hits so that I could have opportunities they only dreamed of. I have followed in this legacy shattering glass ceilings into unrecognizable pieces for those who will come next.

However, breaking through has not come without cuts, bruises, scrapes and wounds. The celebration of smashing stereotypes should at least be balanced with the acknowledgement of the formidable …

In Silico And Functional Analysis Identifies Key Gene Networks And Novel Gene Candidates In Obesity-Linked Human Visceral Fat, Lijin Wang, Pratap Veerabrahma Seshachalam, Ruiming Chua, Hongwen Zhou, Sun Lei, Sujoy Ghosh

Division of Basic Science Faculty Publications

Objective: Visceral adiposity is associated with increased proinflammatory activity, insulin resistance, diabetes risk, and mortality rate. Numerous individual genes have been associated with obesity, but studies investigating gene regulatory networks in human visceral obesity have been lacking. Methods: We analyzed gene regulatory networks in human visceral adipose tissue (VAT) from 48 and 11 Chinese patients with and without obesity, respectively, using gene coexpression and gene regulatory network construction from RNA-sequencing data. We also conducted RNA interference-based functional tests on selected genes for effects on adipocyte differentiation. Results: A scale-free gene coexpression network was constructed from 360 differentially expressed genes between …

Healthy Lifestyle And Cardiac Rehabilitation For Weight Loss, Christoph Höchsmann, James L. Dorling, Carl J. Lavie, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Purpose of Review: Considerable current interest is directed at pharmacological agents for producing significant weight loss. However, healthy lifestyle choices can also lead to clinically meaningful weight loss and improvements in cardiovascular disease (CVD) risk factors. Recent Findings: In this review, we summarize the recent research from our PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) randomized controlled trial and review previous data on the potential benefits of cardiac rehabilitation and exercise training (CRET) programs to produce weight loss and improvements in CVD risk factors. Summary: Although obesity medications are becoming extremely attractive for secondary and even primary …

Genomic Analysis Of Intracranial And Subcortical Brain Volumes Yields Polygenic Scores Accounting For Variation Across Ancestries, Luis M. García-Marín, Adrian I. Campos, Santiago Diaz-Torres, Jill A. Rabinowitz, Zuriel Ceja, Brittany L. Mitchell, Katrina L. Grasby, Jackson G. Thorp, Ingrid Agartz, Saud Alhusaini, David Ames, Philippe Amouyel, Ole A. Andreassen, Konstantinos Arfanakis, Alejandro Arias-Vasquez, Nicola J. Armstrong, Lavinia Athanasiu, Mark E. Bastin, Alexa S. Beiser, David A. Bennett, Joshua C. Bis, Marco P.M. Boks, Dorret I. Boomsma, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Ralph Burkhardt, Wiepke Cahn, Vince D. Calhoun, Owen T. Carmichael, Mallar Chakravarty, Qiang Chen, Christopher R.K. Ching, Sven Cichon

Clinical Research Faculty Publications

Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse …

The Roles Of Vicarious Trauma Exposure And Perceived Social Support In Codeine Syrup Misuse Among Black Men Living In Prisons, Jardin Dogan-Dixon, Shawndaya S. Thrasher, Shemeka Thorpe, Paris Wheeler, Danelle Stevens-Watkins

Faculty Publications

Using General Strain Theory, this study investigates the effects of vicarious trauma exposure and perceived social support on nonmedical codeine syrup misuse among Black incarcerated men nearing community re-entry. Data were drawn from the Helping Incarcerated Men project, a study examining mental health, substance misuse, and human immunodeficiency virus (HIV) risk behaviors among Black men living in prisons who were within 180 days of release. A total of 200 Black men self-reported demographics (i.e., age and length of incarceration after age 18), vicarious trauma exposure (e.g., ever witnessing an assault with a weapon and a sudden accidental death), perceived social …

Precision Synthesis Of Conjugated Polymer Films By Surface-Confined Stepwise Sonogashira Cross-Coupling, Sang Gil Youm, Mitchell T. Howell, Chien Hung Chiang, Lu Lu, Neepa M.K. Kuruppu Arachchige, John F. Ankner, Joseph Strzalka, Yaroslav Losovyj, Jayne C. Garno, Evgueni E. Nesterov

Faculty Publications

Thin films of poly(arylene ethynylene)-conjugated polymers, including low-energy-gap donor–acceptor polymers, can be prepared via stepwise polymerization utilizing surface-confined Sonogashira cross-coupling. This robust and efficient polymerization protocol yields conjugated polymers with a precise molecular structure and with nanometer-level control of the organization and the uniform alignment of the macromolecular chains in the densely packed film. In addition to high stability and predictable and well-defined molecular organization and morphology, the surface-confined conjugated polymer chains experience significant interchain electronic interactions, resulting in dominating intermolecular π-electron delocalization which is primarily responsible for the electronic and spectroscopic properties of polymer films. The fluorescent films demonstrate …

The Sec Spanish Consortium: Foundations For Linguistic Gratuity And Language Documentation Among Latinx Populations In New Destination Communities Of The U.S. South, Stephen Fafulas, Chad Howe, Rafael Orozco, Alicia Cipria, Erin O’Rourke, Nina Moreno, Matthew J. Van Hoose

Faculty Publications

Latinx populations in the USA have grown steadily in recent decades, with significant increases taking place in “new destination communities” of the U.S. South. The focus of our paper is to highlight opportunities for working with these populations, including traditional sociolinguistic ethnographies and community-engaged research. We highlight an initiative named “The SEC Spanish Consortium” which is an interinstitutional collaboration centered on scholarship and service involving Latinx populations in new destination communities of the U.S. South. We show that ongoing and future scholarly work in the U.S. South can act as a mechanism for documenting these emerging Latinx communities while simultaneously …

Editorial Introduction: Policy Actors, Dynamics, And Developments—New Insights From Process Theories And Methodological Applications, Geoboo Song, Gwen Arnold, Melissa K. Merry, Davor Mondom, Ben Galloway, Briana Huett, Camille Gilmore, Saba Siddiki, Holly L. Peterson, Creed Tumlison, Heasun Choi, Meerim Seiitova

Faculty Publications

No abstract provided.

Addressing Knowledge Gaps In Disease Epidemiology And Detection Of Fungicide Resistance In Cercospora Leaf Blight Of Soybean, Stephanie Karen Ramos

LSU Master's Theses

Cercospora leaf blight (CLB) has been the primary foliar disease impacting the soybean crop in the mid-South for over a decade. A poor understanding of disease epidemiology and the prevalence of fungicide resistance have added complexity to management efforts. Recent findings suggest that airborne conidia play a significant role in the outbreak of CLB. We investigated the relationship between weather variables and conidial release using multi-site, multi-year spore trapping data. The findings confirm that C. cf. flagellaris is the dominant CLB pathogen, contributing significantly more conidia than C. cf. sigesbeckiae and C. kikuchii in soybean fields across Arkansas, Mississippi, …

Do #Blm At The Plantation: A Study Of Plantation Tourism After The Racial Reckoning Of 2020, Denetria N. Lee

LSU Master's Theses

Following the murder of George Floyd at the hands of Minneapolis police officer Derek Chauvin, the widespread public protest of racial injustice created a groundswell that prompted corporate and media responses, so much so that by the end of the summer of 2020, it seemed as if "Black Lives Mattered" everywhere and to everyone. Public response incentivized subsequent corporate response in financial pledges and other commitments to racial justice initiatives until 2020, which became known as the year that America confronted racism or the racial reckoning of 2020. While the public demanded acknowledgment of the many forms of contemporary racial …

Effects Of Retinal Gonadotropin-Releasing Hormone On Reproductive Behavior And Retinal Activity In The Cichlid Fish, Astatotilapia Burtoni, Chase Anselmo

LSU Master's Theses

Many animals use visual signals to evade predators, forage for food, and communicate with conspecifics. Some animals that shift into and out of breeding stages, such as fish, can modulate their visual sensitivity to better adapt to changing internal and external conditions. Previous work in our lab demonstrated that females of the cichlid fish Astatotilapia burtoni have improved visual sensitivity when they enter reproductive readiness. However, little is known about how fish and vertebrates more broadly modulate visual sensitivity across their reproductive cycle. We hypothesized that the hormone and neuromodulator gonadotropin-releasing hormone (GnRH) could modulate visual sensitivity because GnRH is …

Evaluating Viability, Developmental Competence, And Chromatin Configurations Of Cryopreserved Equine Oocytes, Tricia Adams

LSU Doctoral Dissertations

Assisted reproduction technology and the use of specialized laboratories have increased in the horse breeding industry over the last decade. This expansion has highlighted the inability to routinely cryopreserve oocytes and preserve female genetics. Oocyte vitrification, a cryopreservation process, continues to be characterized as an experimental procedure in horses. The goal of this dissertation was to evaluate the viability, developmental competence, and nuclear structures of cryopreserved equine oocytes to illuminate potential areas of improvement in the vitrification process. Oocytes were collected from abattoir derived ovaries and exposed to either varying lengths of in vitro maturation (IVM) or pretreated with a …

Intensification Strategies Of Southern Arizona Bilinguals, Sadie E. Seilhan

LSU Master's Theses

The present thesis explores the intensification strategies employed by bilingual Spanish-English speakers in Southern Arizona, focusing on six distinct devices: lexical, phrasal, repetition, reformulation, hyperbole, and code-switching. While previous research has largely centered on adverbial and lexical intensifiers in monolingual contexts, this study broadens the scope by examining how bilingual speakers leverage their unique linguistic repertoire to amplify their speech. Using a sociopragmatic framework, the analysis reveals a marked preference for lexical intensification, which accounts for more than half of the recorded instances, with phrasal intensification and repetition following closely. Despite its lower frequency, code-switching stands out as a particularly …

Healthcare-Seeking Behavior In A Toxic Landscape: Investigating Cancer Care Awareness In Louisiana's Cancer Alley, Moumita Roy

LSU Master's Theses

The fossil fuel and petrochemical sector in the Louisiana region, known as "Cancer Alley," has a devastating impact not only on the environment but also on the health and lives of the local population. Extreme pollution from the petrochemical industry not only elevated cancer rates in this region but also maternal, reproductive, and newborn health harms, respiratory diseases, and other complex health issues. This study examined the healthcare-seeking behavior of some residents and their awareness of cancer facilities within a 100-mile radius of their homes and identified key challenges, such as proximity of cancer care and accessibility, financial constraints, and …