Digital Commons Network^™

Model-Guided Design Of Rna-Based Synthetic Circuits For The Dynamic Regulation Of Gene Expression, Jordan R. Ryan

LSU Master's Theses

A longstanding goal in synthetic biology has been to build synthetic gene circuits with the ability to harness nature’s capability of precise gene expression regulation. Advancements in RNA technology have established RNA-based regulators with distinct advantages over traditional protein-based regulators such as faster signal propagation, versatile programmability, and low cellular burden, which has created an interest in the field to construct innovative synthetic gene circuits using de novo RNA- based regulators. However, our understanding of the behavior and kinetics of RNA-RNA interactions for the construction of gene circuits is incomplete. This thesis proposes a model-guided design framework that integrates mechanistic …

Effects Of Meteorologic Events On Wave Climate And Current Regime In A Shallow, Microtidal Bay, Jay S. Merrill

LSU Master's Theses

Along coastal Louisiana and within the shallow microtidal Barataria Bay estuary, meteorological events can play a primary role in influencing wave climate and circulation patterns. Understanding the effects of hurricanes and smaller tropical storms on hydrodynamic processes is important for constraining and predicting hydrodynamic variation in Barataria Bay, which, largely due to impacts from wave energy, is currently experiencing rapid wetland loss and is a major focus of coastal restoration efforts. Two bottom-mounted upward-facing Acoustic Current Doppler Profilers and wave, temperature, and depth recorders were installed in the lower portions of Barataria Bay to measure the wave climate and three-dimensional …

Trump’S Trade War: An Economic And Diplomatic Analysis From A Louisianan’S Perspective, Logan P. Berthelot

Honors Capstones

No abstract provided.

Opers On The Projective Line, Wronskian Relations, And The Bethe Ansatz, Ty J. Brinson

Honors Capstones

No abstract provided.

Analytical, Numerical, And Computational Simulation Of The Free Convection Cooling Of An Electronics Enclosure For Assistive Painting Device, Jack Clement

Honors Capstones

No abstract provided.

Resistance Allele Frequency To Cry1ab And Vip3aa20 In Helicoverpa Zea (Boddie) (Lepidoptera: Noctuidae) In Louisiana And Three Other Southeastern U.S. States, Shucong Lin, Isaac Oyediran, Ying Niu, Sebe Brown, Don Cook, Xinzhi Ni, Yan Zhang, Francis P.F. Reay-Jones, Jeng Shong Chen, Zhimou Wen, Marcelo Dimase, Fangneng Huang

Faculty Publications

The corn earworm/bollworm, Helicoverpa zea (Boddie), is a pest species that is targeted by both Bacillus thuringiensis (Bt) maize and cotton in the United States. Cry1Ab and Vip3Aa20 are two common Bt toxins that are expressed in transgenic maize. The objective of this study was to determine the resistance allele frequency (RAF) to Cry1Ab and Vip3Aa20 in H. zea populations that were collected during 2018 and 2019 from four southeastern U.S. states: Louisiana, Mississippi, Georgia, and South Carolina. By using a group-mating approach, 104 F2 iso-lines of H. zea were established from field collections with most iso-lines (85) from Louisiana. …

Investigating The Overexpression Of And Molecular Mechanism Utilized By Acetyl-Coa Carboxylase, Blaire Peterson

Honors Capstones

No abstract provided.

Strain Energy-Based Fatigue Failure Analyses Of Lb-Pbf Inconel 718: Effect Of Build Orientation, Arash P. Jirandehi, Behnam Hajshirmohammadi, Patricio Carrion, M. M. Khonsari, Nima Shamsaei, Shuai Shao

Faculty Publications

Additively manufactured Inconel 718 parts fabricated in three build orientations (horizontal, vertical, and angled at 45 degrees) are tested in fully-reversed bending fatigue mode. Damping measurements via the Impulse Excitation technique are used to assess the defects content in the microstructure and fractography analysis is performed to detect the root cause of failure. Two micro- and macro-scale methodologies of fatigue damage estimation based on the dissipated heat per cycle and the statistical estimation of micro-plastic strain energies are used to assess fatigue damage. It is shown that at a given stress level, the vertically built specimens endure the most fatigue …

Collisions On Campus: Species-Specific Susceptibility Of Resident And Migrant Birds To Window Strikes At Louisiana State University, Jordan A. Mouton

Honors Capstones

No abstract provided.

Mathematica Assessment Of Spatial Reasoning Development After Virtual Reality Collaboration, Arthur Odenheimer

Honors Capstones

No abstract provided.

Observing Reactive Events At The Aqueous Graphene Oxide Interface Using Deep Neural Network Potentials, Lukas Kim

Honors Capstones

No abstract provided.

Observing And Exploring Intrinsic Characteristics Of Type Ia Supernova, Connor Langevin

Honors Capstones

No abstract provided.

Expression And Purification Of Tag-Free Chlamydia Trachomatis Scc4 For Improved Nmr Structural Studies, Peter Howard

Honors Capstones

No abstract provided.

Generative Adversarial Networks Take On Hand Drawn Sketches: An Application To Louisiana Culture And Mardi Gras Fashion, Stephanie Hines

Honors Capstones

No abstract provided.

Gl(1|1) Graph Connections, Andrea Bourque

Honors Capstones

No abstract provided.

Trophic Relationships Between Tadpoles And Other Aquatic Organisms In Sub-Tropical Ponds, Kira Cates

Honors Capstones

No abstract provided.

The Effect Of Channel Stability On Fish Condition And Diet In Thompson Creek, La, Alexia Lagrone

Honors Capstones

No abstract provided.

The Effects Of Poverty On The Quality Of Education Received By Louisiana Students, Madison Brzezinski

Honors Capstones

No abstract provided.

Early Foundational Cultures Of Modern Spain, Emily Webre

Honors Capstones

No abstract provided.

Democracy’S Effect On Attributes Of Transnational Terrorism, Alice Epley

Honors Capstones

No abstract provided.

Are Long-Period Exoplants Around Cool Stars More Common Than We Thought?, Emily Jane Safron

LSU Doctoral Dissertations

The Kepler mission has been the catalyst for discovery of nearly 5,000 confirmed and candidate exoplanets. The majority of these candidates orbit Sun-like stars, and have orbital periods comparable to or shorter than that of the Earth, due to the selection bias inherent in the transit method and the limitations of automated transit search algorithms. We aim to develop a richer understanding of the population of exoplanets around the lowest-mass stars, the M spectral type. We are particularly interested in exoplanets with long orbital periods, which are difficult or impossible to find using standard transit search algorithms. In our study, …

Performance Analysis And Improvement For Scalable And Distributed Applications Based On Asynchronous Many-Task Systems, Nanmiao Wu

LSU Doctoral Dissertations

As the complexity of recent and future large-scale data and exascale systems architectures grows, so do productivity, portability, software scalability, and efficient utilization of system resources challenges presented to both industry and the research community. Software solutions and applications are expected to scale in performance on such complex systems. Asynchronous many-task (AMT) systems, taking advantage of multi-core architectures with light-weight threads, asynchronous executions, and smart scheduling, are showing promise in addressing these challenges.

In this research, we implement several scalable and distributed applications based on HPX, an exemplar AMT runtime system. First, a distributed HPX implementation for a parameterized benchmark …

Synthesis Of Thiol-Acrylate Hydrogels For 3d Cell Culture And Microfluidic Applications, Anowar Hossain Khan

LSU Doctoral Dissertations

Globally cell culture is an $18.98 billion industry as of 2020, with an 11.6 percent annual growth rate. Drug discovery has an estimated worth of $69.8 billion in 2020 and is predicted to grow to $110.4 billion by 2025. Three-dimensional (3D) cell culture of cancer cells is one of the rapidly growing felids since it better recapitulates in vivo conditions compared to two-dimensional (2D) models. However, it is challenging to grow 3D tumor spheroids outside the body, and some of the existing technology can generate these spheroids outside the human body but poorly mimic in vivo tumor models. Therefore, there …

The Spectra Of Hydrogen-Deficient Carbon Stars: The Effects Of Evolution And Nucleosynthesis, Courtney Lauren Crawford

LSU Doctoral Dissertations

The rare class of stars known as the Hydrogen-deficient Carbon (HdC) stars includes the R Coronae Borealis (RCB) variables and the non-variable Dustless HdC (dLHdC) stars. These stars are believed to be formed via the merger of two white dwarf (WD) stars. They are known to exhibit many spectral peculiarities, such as partial helium burning products, enhancement of s-processed material and severe hydrogen-deficiency. In this work I explore many facets of HdC evolution. I begin by creating 18 HdC models in the stellar evolution code Modules for Experiments in Stellar Astrophysics (MESA) by merging two WD progenitors and evolving the …

The Application Of Physics Informed Neural Networks To Compositional Modeling, Thelma A. Ihunde

LSU Master's Theses

Compositional modeling is essential when simulating processes involving significant changes in reservoir fluid composition. It is computationally expensive because we typically need to predict the states and properties of multicomponent fluid mixtures at several different points in space and time. To speed up this process, several researchers have used machine learning algorithms to train deep learning (DL) models on data from the rigorous phase-equilibrium (flash) calculations. However, one shortcoming of the DL models is that there is no explicit consideration for the governing physics. So, there is no guarantee that the model predictions will honor the thermodynamical constraints of phase …

Maintenance Cost Minimization Models For Offshore Wind Farms: A Systematic And Critical Review, Md Imran Hasan Tusar, Bhaba R. Sarker

Faculty Publications

Feasible and sustainable source of power is a burning question nowadays. The offshore wind farms can be a solution to power generation problem, but it is relatively more expensive. Its installation cost is more than twice of its similar size onshore counterpart. The cost that matters most is the operations and maintenance (O&M) cost. Expensive and sophisticated transfer vehicles as well as highly skilled technicians are needed to conduct O&M activities, which results in a remarkably higher O&M cost for an offshore wind farm project. Few researchers proposed some strategies that could resolve the problem nicely, although there is no …

Tutorial: Thermomechanical Constitutive Modeling Of Shape Memory Polymers, Cheng Yan, Guoqiang Li

Faculty Publications

Shape memory polymers (SMPs) are one of the intriguing functional materials and have been widely and intensively studied. In order to apply these new polymers to load bearing engineering structures and devices, developing physics-based thermomechanical constitutive models is mandatory. The aim of this Tutorial is to demonstrate how to establish a thermomechanical constitutive model for SMPs. It begins with classifications of SMPs, followed by a discussion on the underlying physics for different SMPs. After that, three classical SMP thermomechanical modeling frameworks are introduced, which include the visco-elasto-plastic based rheological framework, the storage strain-based phase transition framework, and the representative unit …

Tuning Electrochemical Interactions And Polymer Electrolyte Interfaces For Enhanced Organic Acid Separations Using Electrodeionization, Matthew Leo Jordan

LSU Doctoral Dissertations

Chemical separations are critical processes for chemical and industrial plants to purify and isolate products however current separation technologies, such as distillation, rely on energy intensive processes. Electrochemical separation processes, such as electrodialysis and electrodeionization, are an energy efficient alternative that are emerging as an alternative for thermal-based separations. Organic acids are weakly ionizable species and susceptible for purification from process streams using electrochemical processes. Recently the fermentation route has garnered greater attention as a means for producing value-added chemicals, such as organic acids, from a renewable feedstock and aiding the circular economy. Some of the challenges electrodialysis faces for …

Connectivity And Directionality In Estuarine Channel Networks, Matthew Hiatt, Elisabeth A. Addink, Maarten G. Kleinhans

Faculty Publications

No abstract provided.

Computational Study Of The Reactions Of Heteroatomic Compounds On Ceo2, Suman Bhasker Ranganath

LSU Doctoral Dissertations

The mechanisms of ambient-temperature reactions of heteroatomic compounds catalyzed by ceria (CeO₂), an archetypical reducible oxide, for enzyme mimetics, environmental protection, and chemical synthesis are investigated in this dissertation using theoretical methods. CeO₂ is modeled with thermodynamically stable low-index surfaces exposed by commonly studied ceria thin films and nano particles. To understand phosphatase-like dephosphorylation activity, stable adsorption states and surface reactions of model phosphates are examined. Binding of the central P-atom to surface lattice oxygen (O_latt) supplemented by phosphoryl O-Ce interaction is the only stable adsorption state for the un-dissociated molecule. Deprotonation of phosphate monoesters, …