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Multi-Agent Optimal Control For Central Chiller Plants Using Reinforcement Learning And Game Theory, Shunian Qiu, Zhenhai Li, Zhihong Pang, Zhengwei Li, Yinying Tao Mar 2023

Multi-Agent Optimal Control For Central Chiller Plants Using Reinforcement Learning And Game Theory, Shunian Qiu, Zhenhai Li, Zhihong Pang, Zhengwei Li, Yinying Tao

Faculty Publications

To conserve building energy, optimal operation of a building’s energy systems, especially heating, ventilation and air-conditioning (HVAC) systems, is important. This study focuses on the optimization of the central chiller plant, which accounts for a large portion of the HVAC system’s energy consumption. Classic optimal control methods for central chiller plants are mostly based on system performance models which takes much effort and cost to establish. In addition, inevitable model error could cause control risk to the applied system. To mitigate the model dependency of HVAC optimal control, reinforcement learning (RL) algorithms have been drawing attention in the HVAC control …

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Short-Term Variation In Leaf-Level Water Use Efficiency In A Tropical Forest, Kenneth J. Davidson, Julien Lamour, Alistair Rogers, Kim S. Ely, Qianyu Li, Nate G. Mcdowell, Alexandria L. Pivovaroff, Brett T. Wolfe, S. Joseph Wright, Alfonso Zambrano, Shawn P. Serbin Mar 2023

Short-Term Variation In Leaf-Level Water Use Efficiency In A Tropical Forest, Kenneth J. Davidson, Julien Lamour, Alistair Rogers, Kim S. Ely, Qianyu Li, Nate G. Mcdowell, Alexandria L. Pivovaroff, Brett T. Wolfe, S. Joseph Wright, Alfonso Zambrano, Shawn P. Serbin

Faculty Publications

The representation of stomatal regulation of transpiration and CO2 assimilation is key to forecasting terrestrial ecosystem responses to global change. Given its importance in determining the relationship between forest productivity and climate, accurate and mechanistic model representation of the relationship between stomatal conductance (gs) and assimilation is crucial. We assess possible physiological and mechanistic controls on the estimation of the g1 (stomatal slope, inversely proportional to water use efficiency) and g0 (stomatal intercept) parameters, using diurnal gas exchange surveys and leaf-level response curves of six tropical broadleaf evergreen tree species. g1 estimated from ex situ response curves averaged 50% less …

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Physical Activity And Weight Loss In A Pragmatic Weight Loss Trial, Peter T. Katzmarzyk, Emily F. Mire, Corby K. Martin, Robert L. Newton, John W. Apolzan, Kara D. Denstel, William D. Johnson, Phillip Brantley, Ronald Horswell, Benjamin F. Springgate, Terry C. Davis, Connie L. Arnold, Eboni Price-Haywood, Carl J. Lavie, Vivian A. Fonseca, Tina K. Thethi, Jonathan Gugel, Kathleen B. Kennedy, Daniel F. Sarpong Mar 2023

Physical Activity And Weight Loss In A Pragmatic Weight Loss Trial, Peter T. Katzmarzyk, Emily F. Mire, Corby K. Martin, Robert L. Newton, John W. Apolzan, Kara D. Denstel, William D. Johnson, Phillip Brantley, Ronald Horswell, Benjamin F. Springgate, Terry C. Davis, Connie L. Arnold, Eboni Price-Haywood, Carl J. Lavie, Vivian A. Fonseca, Tina K. Thethi, Jonathan Gugel, Kathleen B. Kennedy, Daniel F. Sarpong

Clinical Research Faculty Publications

The purpose of this study was to determine the association between changes in physical activity and changes in body weight in a cluster-randomized weight loss trial conducted in an underserved population in Louisiana. This study reports analyses conducted in the intervention group only, which was a 24-month multi-component weight loss program delivered by health coaches embedded in primary care clinics. Physical activity was assessed at baseline and at 6, 12, and 24 months of follow-up and changes in body weight were expressed as percent weight change from baseline. Among the sample of 402 patients, percent changes in body weight (mean …

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Electronic Cigarette Nicotine Flux, Nicotine Yield, And Particulate Matter Emissions: Impact Of Device And Liquid Heterogeneity, Eric K. Soule, Shannon Mayne, William Snipes, Elizabeth K. Do, Travis Theall, Christoph Höchsmann, Soha Talih, Corby K. Martin, Thomas Eissenberg, Bernard F. Fuemmeler Mar 2023

Electronic Cigarette Nicotine Flux, Nicotine Yield, And Particulate Matter Emissions: Impact Of Device And Liquid Heterogeneity, Eric K. Soule, Shannon Mayne, William Snipes, Elizabeth K. Do, Travis Theall, Christoph Höchsmann, Soha Talih, Corby K. Martin, Thomas Eissenberg, Bernard F. Fuemmeler

Clinical Research Faculty Publications

Introduction: Electronic cigarettes (ECIGs) heat a nicotine-containing liquid to produce an inhalable aerosol. ECIG power (wattage) and liquid nicotine concentration are two factors that predict nicotine emission rate ("flux"). These factors can vary greatly across devices and users. Aims and Methods: The purpose of this study was to examine ECIG device and liquid heterogeneity in "real world"settings and the association with predicted nicotine flux, nicotine yield, and total particulate matter (TPM) emissions. Past 30-day ECIG users (n = 84; mean age = 23.8 years [SD = 9.6]) reported device and liquid characteristics. Device power was measured via multimeter, device display …

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A Fracture Multiscale Model For Peridynamic Enrichment Within The Partition Of Unity Method, Matthias Birner, Patrick Diehl, Robert Lipton, Marc Alexander Schweitzer Mar 2023

A Fracture Multiscale Model For Peridynamic Enrichment Within The Partition Of Unity Method, Matthias Birner, Patrick Diehl, Robert Lipton, Marc Alexander Schweitzer

Faculty Publications

Partition of unity methods are of domain decomposition type and provide the opportunity for multiscale and multiphysics numerical modeling. Different physical models can exist within a partition of unity method scheme for handling problems with zones of linear elasticity and zones where fractures occur. Here, the peridynamic model is used in regions of fracture and smooth partition of unity methods is used in the surrounding linear elastic media. Our method is novel in that we evolve the crack path using peridynamics and apply the partition of unity method to compute the elastic fields in the neighborhood of the crack tip. …

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Witnessing Entangled Two-Photon Absorption Via Quantum Interferometry, Áulide Martínez-Tapia, Samuel Corona-Aquino, Freiman Triana-Arango, Chenglong You, Rui Bo Jin, Omar S. Magaña-Loaiza, Shi Hai Dong, Alfred B. U'Ren, Roberto De J. León-Montiel Mar 2023

Witnessing Entangled Two-Photon Absorption Via Quantum Interferometry, Áulide Martínez-Tapia, Samuel Corona-Aquino, Freiman Triana-Arango, Chenglong You, Rui Bo Jin, Omar S. Magaña-Loaiza, Shi Hai Dong, Alfred B. U'Ren, Roberto De J. León-Montiel

Faculty Publications

Recent investigations have suggested that the use of non-classical states of light, such as entangled photon pairs, may open new and exciting avenues in experimental two-photon absorption spectroscopy. Despite several experimental studies of entangled two-photon absorption (eTPA), there is still a heated debate on whether eTPA has truly been observed. This interesting debate has arisen mainly because it has recently been argued that single-photon-loss mechanisms, such as scattering or hot-band absorption, may mimic the expected entangled-photon linear absorption behavior. In this work, we focus on transmission measurements of eTPA and explore three different two-photon quantum interferometers in the context of …

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Unhealthy Herds And The Predator–Spreader: Understanding When Predation Increases Disease Incidence And Prevalence, Robert L. Richards, Bret D. Elderd, Meghan A. Duffy Mar 2023

Unhealthy Herds And The Predator–Spreader: Understanding When Predation Increases Disease Incidence And Prevalence, Robert L. Richards, Bret D. Elderd, Meghan A. Duffy

Faculty Publications

Disease ecologists now recognize the limitation behind examining host–parasite interactions in isolation: community members—especially predators—dramatically affect host–parasite dynamics. Although the initial paradigm was that predation should reduce disease in prey populations (“healthy herds hypothesis”), researchers have realized that predators sometimes increase disease in their prey. These “predator–spreaders” are now recognized as critical to disease dynamics, but empirical research on the topic remains fragmented. In a narrow sense, a “predator–spreader” would be defined as a predator that mechanically spreads parasites via feeding. However, predators affect their prey and, subsequently, disease transmission in many other ways such as altering prey population structure, …

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On The Effect Of Environmental Temperature On Fracture Fatigue Entropy, Mohammad A. Amooie, M. M. Khonsari Mar 2023

On The Effect Of Environmental Temperature On Fracture Fatigue Entropy, Mohammad A. Amooie, M. M. Khonsari

Faculty Publications

Fracture behavior of carbon steel 1018 operating in low-temperature environments is investigated. Specifically, fully-reversed bending experimental tests are performed to examine the efficacy of applying the concept of Fracture Fatigue Entropy (FFE) for predicting fatigue life at different environmental temperatures. A large cooling chamber was constructed that houses the entire bending test rig and maintains the environmental temperature at the desired value down to −10 °C. It is shown that under conditions tested, fatigue life improves at lower operating temperatures. Results also reveal that FFE remains nearly constant and can be used for reliable prediction of fatigue life. Illustrative examples …

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A New Generation Of Dense-Graded Asphalt Mixtures With Superior Performance Against Stripping And Moisture Damage, Mostafa Elseifi, Zahid Hossain, Md. T.A. Sarkar, Hossam Abohamer, Mohammad Oyan Mar 2023

A New Generation Of Dense-Graded Asphalt Mixtures With Superior Performance Against Stripping And Moisture Damage, Mostafa Elseifi, Zahid Hossain, Md. T.A. Sarkar, Hossam Abohamer, Mohammad Oyan

Publications

The presence of moisture beneath the pavement surface is a matter of great concerns as it is responsible for significant distresses such as asphalt concrete (AC) stripping, fatigue cracking, rutting, and poor durability of asphalt mixes. The objective of this study was to evaluate and recommend an asphalt mixture design that would provide superior performance against AC stripping and cracking. To achieve this objective, a laboratory test factorial was developed to evaluate the use of nanomaterials, emerging anti-stripping agents, warm-mix asphalt technologies, and adhesion promotors. In the experimental program, the modified Lottman test (AASHTO T 283) and the Indirect Tensile …

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Pricing Multi-Asset Contingent Claims In A Multi-Dimensional Binomial Market, Jarek Kedra, Assaf Libman, Victoria Steblovskaya Feb 2023

Pricing Multi-Asset Contingent Claims In A Multi-Dimensional Binomial Market, Jarek Kedra, Assaf Libman, Victoria Steblovskaya

Journal of Stochastic Analysis

No abstract provided.

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Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon Feb 2023

Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon

Faculty Publications

While nature can benefit people both mentally and physically, contemporary society has become increasingly disconnected from nature. To rebuild a stronger connection with nature in our everyday life, we introduce FloraWear, a do-it-yourself, wearable living interface, that enables people to easily and closely connect with plants. This pictorial introduces how knowledge is built and shared with others using hybrid craft and fabrication, illustrates the material experiments and design development for FloraWear, and discusses how it affects wearers. Then we summarize how FloraWear can help catalyze a shift in people's perspectives towards nature. By developing emotional ties to their wearable plants, …

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Hybrid Modeling For Electrochemical Systems, Luis Alejandro Briceno-Mena Feb 2023

Hybrid Modeling For Electrochemical Systems, Luis Alejandro Briceno-Mena

LSU Doctoral Dissertations

The discovery of new materials like catalysts, polymeric films, and biomolecules, is driven by industrial needs such as improving reaction or separation selectivity, enhancing therapeutic effects on medical treatments, or reducing costs of replacement. However, deployment of these advances in industrial applications is often hindered by the lack of models needed for design and optimization. Due to the novelty of materials and devices, experimental data and first principles' knowledge are scarce, making it hard to build models either via data-driven or knowledge based approaches. In this context, a way to efficiently combine domain knowledge with data could provide a pathway …

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Analysis And Technical Optimization Of Processing Condition For Better Quality Of Robusta Coffee Production, Usman Ahmad, Khalimatus Sa’Diyah, Sathivel Subramaniam Feb 2023

Analysis And Technical Optimization Of Processing Condition For Better Quality Of Robusta Coffee Production, Usman Ahmad, Khalimatus Sa’Diyah, Sathivel Subramaniam

Faculty Publications

The wet processing of robusta coffee starts with harvesting coffee cherries, followed by sorting the cherries, pulping, fermentation, washing, drying, hard skin hulling, bean sorting, and packaging. Soaking fruit before pulping is an alternative for coffee farmers to delay the pulping process if time does not al-low it. The fermentation process aims to remove mucus that is firmly attached to the hard skin. The addition of L. casei bacteria can accelerate the process but affect the final taste. This study aimed to optimize the duration of soaking and fermentation processes for obtaining coffee beans with a minimum number of unpeeled …

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The Malliavin-Stein Method For Normal Random Walks With Dependent Increments, Ian Flint, Nicolas Privault, Giovanni Luca Torrisi Feb 2023

The Malliavin-Stein Method For Normal Random Walks With Dependent Increments, Ian Flint, Nicolas Privault, Giovanni Luca Torrisi

Journal of Stochastic Analysis

No abstract provided.

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Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang Feb 2023

Enhanced Phase Sensitivity In A Mach-Zehnder Interferometer Via Photon Recycling, Dong Li, Chun Hua Yuan, Xiaoping Ma, Qingle Wang, Hwang Lee, Yao Yao, Weiping Zhang

Faculty Publications

We propose an alternative scheme for phase estimation in a Mach-Zehnder interferometer (MZI) with photon recycling. It is demonstrated that with the same coherent-state input and homodyne detection, our proposal possesses a phase sensitivity beyond the traditional MZI. For instance, it can achieve an enhancement factor of ∼9.32 in the phase sensitivity compared with the conventional scheme even with a photon loss of 10% on the photon-recycled arm. From another point of view, the quantum Cramér-Rao bound (QCRB) is also investigated. It is found that our scheme is able to achieve a lower QCRB than the traditional one. Intriguingly, the …

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Atomistic Simulation Studies Of Thin Film Growth And Plastic Deformation In Metals And Metal/Ceramic Nanostructures, Reza Namakian Feb 2023

Atomistic Simulation Studies Of Thin Film Growth And Plastic Deformation In Metals And Metal/Ceramic Nanostructures, Reza Namakian

LSU Doctoral Dissertations

Despite the significant improvements in manufacturing and synthesis processes of metals and ceramics in the past decades, there are still areas in which the procedure is still frequently more of an art or skill rather than a science. Therefore, systematic and combined experimental and computational studies are required to facilitate the development of techniques that offer thorough understanding of the events taking place during manufacturing and synthesis processes. With regard to these issues, it is paramount to address microscale characterizations and atomic scale understanding of the events during fabrication processes. One of the focuses of this study is unraveling fundamental …

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Well Placement Optimization Through The Triple-Completion Gas And Downhole Water Sink-Assisted Gravity Drainage (Tc-Gdws-Agd) Eor Process, Watheq J. Al-Mudhafar, David A. Wood, Dahlia A. Al-Obaidi, Andrew K. Wojtanowicz Feb 2023

Well Placement Optimization Through The Triple-Completion Gas And Downhole Water Sink-Assisted Gravity Drainage (Tc-Gdws-Agd) Eor Process, Watheq J. Al-Mudhafar, David A. Wood, Dahlia A. Al-Obaidi, Andrew K. Wojtanowicz

Faculty Publications

Gas and downhole water sink-assisted gravity drainage (GDWS-AGD) is a new process of enhanced oil recovery (EOR) in oil reservoirs underlain by large bottom aquifers. The process is capital intensive as it requires the construction of dual-completed wells for oil production and water drainage and additional multiple vertical gas-injection wells. The costs could be substantially reduced by eliminating the gas-injection wells and using triple-completed multi-functional wells. These wells are dubbed triple-completion-GDWS-AGD (TC-GDWS-AGD). In this work, we design and optimize the TC-GDWS-AGD oil recovery process in a fictitious oil reservoir (Punq-S3) that emulates a real North Sea oil field. The design …

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Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith Feb 2023

Glucagon-Like Peptide-1/Glucagon Receptor Agonism Associates With Reduced Metabolic Adaptation And Higher Fat Oxidation: A Randomized Trial, Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre Philippe Luyet, Britta Göbel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith

Clinical Research Faculty Publications

Objective: This study tested the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation). Methods: This Phase 1b, double-blind, randomized, placebo-controlled study was conducted at two centers in inpatient metabolic wards. Thirty-five healthy males and females with overweight and obesity (age = 36.5 ± 7.1 years) were randomized to a calorie-reduced diet (−1000 kcal/d) and escalating doses (0.06-0.2 mg/d) of SAR425899 (n = 17) or placebo (n = 18) for 19 days. SMR was measured …

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Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson Feb 2023

Early Time-Restricted Eating Affects Weight, Metabolic Health, Mood, And Sleep In Adherent Completers: A Secondary Analysis, Felicia L. Steger, Humaira Jamshed, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah Jeanne Salvy, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Data are mixed on whether intermittent fasting improves weight loss and cardiometabolic health. Here, the effects of time-restricted eating (TRE) in participants who consistently adhered ≥5 d/wk every week were analyzed. Methods: Ninety patients aged 25 to 75 years old with obesity were randomized to early TRE (eTRE; 8-hour eating window from 07:00 to 15:00) or a control schedule (≥12-hour window) for 14 weeks. A per-protocol analysis of weight loss, body composition, cardiometabolic health, and other end points was performed. Results: Participants who adhered to eTRE ≥5 d/wk every week had greater improvements in body weight (−3.7 ± 1.2 …

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Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson Feb 2023

Impact Of Early Time-Restricted Eating On Diet Quality, Meal Frequency, Appetite, And Eating Behaviors: A Randomized Trial, Felicia L. Steger, Humaira Jamshed, Corby K. Martin, Joshua S. Richman, David R. Bryan, Cody J. Hanick, Sarah Jeanne Salvy, Amy H. Warriner, Courtney M. Peterson

Clinical Research Faculty Publications

Objective: Time-restricted eating (TRE) can reduce body weight, but it is unclear how it influences dietary patterns and behavior. Therefore, this study assessed the effects of TRE on diet quality, appetite, and several eating behaviors. Methods: Adults with obesity were randomized to early TRE plus energy restriction (eTRE + ER; 8-hour eating window from 7:00 a.m. to 3:00 p.m.) or a control eating schedule plus energy restriction (CON + ER; ≥12-hour window) for 14 weeks. Food intake was assessed via the Remote Food Photography Method, while eating patterns, appetite, and eating behaviors were assessed via questionnaires. Results: A total of …

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Effects Of Covid-19 On Sensory And Cognitive Perception Of Mild And Severe Diagnosed And Recovered Patients Versus Healthy Consumers, Adan Cabal-Prieto, Lucía Sánchez-Arellano, José Andrés Herrera-Corredor, Jesús Rodríguez-Miranda, Witoon Prinyawiwatkul, Lorena Guadalupe Ramón-Canul, Filiberto Toledano-Toledano, Ingrid Mayanin Rodríguez-Buenfil, Manuel Octavio Ramírez-Sucre, Gregorio Hernández-Salinas, Emmanuel De Jesús De Ramírez-Rivera Feb 2023

Effects Of Covid-19 On Sensory And Cognitive Perception Of Mild And Severe Diagnosed And Recovered Patients Versus Healthy Consumers, Adan Cabal-Prieto, Lucía Sánchez-Arellano, José Andrés Herrera-Corredor, Jesús Rodríguez-Miranda, Witoon Prinyawiwatkul, Lorena Guadalupe Ramón-Canul, Filiberto Toledano-Toledano, Ingrid Mayanin Rodríguez-Buenfil, Manuel Octavio Ramírez-Sucre, Gregorio Hernández-Salinas, Emmanuel De Jesús De Ramírez-Rivera

Faculty Publications

The objective of this research was to analyze the effects of the SARS-CoV-2 virus on the sensory and cognitive perception of mild and severe COVID-19 diagnosed and recovered consumers versus healthy consumers. Three groups of 50 consumers each (healthy vs. mild and severe COVID-19 diagnosed with 30 days after recovery) were used for the evaluation of instant coffee stimuli in concentrations: 4.40, 2.93, 2.20, 1.76, and 1.47% weight (w)/volume (v) and determine their discriminating power, emotions, and memories. Sensory tests were performed remotely. Results indicated that healthy consumers perceived higher intensities in most of the sensory attributes (with the exception …

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Correction To: Parametrized Topological Complexity Of Collision-Free Motion Planning In The Plane (Annals Of Mathematics And Artificial Intelligence, (2022), 90, 10, (999-1015), 10.1007/S10472-022-09801-6), Daniel C. Cohen, Michael Farber, Shmuel Weinberger Feb 2023

Correction To: Parametrized Topological Complexity Of Collision-Free Motion Planning In The Plane (Annals Of Mathematics And Artificial Intelligence, (2022), 90, 10, (999-1015), 10.1007/S10472-022-09801-6), Daniel C. Cohen, Michael Farber, Shmuel Weinberger

Faculty Publications

The article “Parametrized topological complexity of collision-free motion planning in the plane”, written by Daniel C. Cohen, was originally published electronically on the publisher’s internet portal on 07 October 2022 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 30 May 2022 to © The Author(s) 2022 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a …

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Non-Quasiconvex Subgroups Of Hyperbolic Groups Via Stallings-Like Techniques, Pallavi Dani, Ivan Levcovitz Feb 2023

Non-Quasiconvex Subgroups Of Hyperbolic Groups Via Stallings-Like Techniques, Pallavi Dani, Ivan Levcovitz

Faculty Publications

We provide a new method of constructing non-quasiconvex subgroups of hyperbolic groups by utilizing techniques inspired by Stallings’ foldings. The hyperbolic groups constructed are in the natural class of right-angled Coxeter groups (RACGs for short) and can be chosen to be 2-dimensional. More specifically, given a non-quasiconvex subgroup of a (possibly non-hyperbolic) RACG, our construction gives a corresponding non-quasiconvex subgroup of a hyperbolic RACG. We use this to construct explicit examples of non-quasiconvex subgroups of hyperbolic RACGs including subgroups whose generators are as short as possible (length two words), finitely generated free subgroups, non-finitely presentable subgroups, and subgroups of fundamental …

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Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa Feb 2023

Envirome-Wide Associations Enhance Multi-Year Genome-Based Prediction Of Historical Wheat Breeding Data, Germano Costa-Neto, Leonardo Crespo-Herrera, Nick Fradgley, Keith Gardner, Alison R. Bentley, Susanne Dreisigacker, Roberto Fritsche-Neto, Osval A. Montesinos-López, Jose Crossa

Faculty Publications

Linking high-throughput environmental data (enviromics) to genomic prediction (GP) is a cost-effective strategy for increasing selection intensity under genotype-by-environment interactions (G × E). This study developed a data-driven approach based on Environment–Phenotype Association (EPA) aimed at recycling important G × E information from historical breeding data. EPA was developed in two applications: (1) scanning a secondary source of genetic variation, weighted from the shared reaction-norms of past-evaluated genotypes and (2) pinpointing weights of the similarity among trial-sites (locations), given the historical impact of each envirotyping data variable for a given site. These results were then used as a dimensionality reduction …

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A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe Feb 2023

A Simple Micromilled Microfluidic Impedance Cytometer With Vertical Parallel Electrodes For Cell Viability Analysis, Jason Eades, Julianne F. Audiffred, Micah Fincher, Jin Woo Choi, Steven A. Soper, William Todd Monroe

Faculty Publications

Microfluidic impedance cytometry has been demonstrated as an effective platform for single cell analysis, taking advantage of microfabricated features and dielectric cell sensing methods. In this study, we present a simple microfluidic device to improve the sensitivity, accuracy, and throughput of single suspension cell viability analysis using vertical sidewall electrodes fabricated by a widely accessible negative manufacturing method. A microchannel milled through a 75 µm platinum wire, which was embedded into poly-methyl-methacrylate (PMMA), created a pair of parallel vertical sidewall platinum electrodes. Jurkat cells were interrogated in a custom low-conductivity buffer (1.2 ± 0.04 mS/cm) to reduce current leakage and …

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Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran Jan 2023

Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran

LSU Doctoral Dissertations

This dissertation explores the mechanisms driving sediment transport and deposition on the continental shelf and within the bays of the northern Gulf of Mexico via a suite of geophysical methods and sediment cores on a variety of timescales. This dissertation is comprised of three main chapters, each focusing on a different location, environment, and process but tied together using geophysical survey, a thematic focus on geomorphic change and sediment transport within the deltaic cycle and deltaic plain environments, and the implications this change poses for both past and future sediment transport and environmental change in response to sea level change. …

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Publisher Correction: A Very Luminous Jet From The Disruption Of A Star By A Massive Black Hole (Nature, (2022), 612, 7940, (430-434), 10.1038/S41586-022-05465-8), Igor Andreoni, Michael W. Coughlin, Daniel A. Perley, Yuhan Yao, Wenbin Lu, S. Bradley Cenko, Harsh Kumar, Shreya Anand, Anna Y.Q. Ho, Mansi M. Kasliwal, Antonio De Ugarte Postigo, Ana Sagués-Carracedo, Steve Schulze, D. Alexander Kann, S. R. Kulkarni, Jesper Sollerman, Nial Tanvir, Armin Rest, Luca Izzo, Jean J. Somalwar, David L. Kaplan, Tomás Ahumada, G. C. Anupama, Katie Auchettl, Sudhanshu Barway, Eric C. Bellm, Varun Bhalerao, Joshua S. Bloom, Michael Bremer, Mattia Bulla, Eric Burns, Sergio Campana, Poonam Chandra Jan 2023

Publisher Correction: A Very Luminous Jet From The Disruption Of A Star By A Massive Black Hole (Nature, (2022), 612, 7940, (430-434), 10.1038/S41586-022-05465-8), Igor Andreoni, Michael W. Coughlin, Daniel A. Perley, Yuhan Yao, Wenbin Lu, S. Bradley Cenko, Harsh Kumar, Shreya Anand, Anna Y.Q. Ho, Mansi M. Kasliwal, Antonio De Ugarte Postigo, Ana Sagués-Carracedo, Steve Schulze, D. Alexander Kann, S. R. Kulkarni, Jesper Sollerman, Nial Tanvir, Armin Rest, Luca Izzo, Jean J. Somalwar, David L. Kaplan, Tomás Ahumada, G. C. Anupama, Katie Auchettl, Sudhanshu Barway, Eric C. Bellm, Varun Bhalerao, Joshua S. Bloom, Michael Bremer, Mattia Bulla, Eric Burns, Sergio Campana, Poonam Chandra

Faculty Publications

In the version of this article initially published, there was in an error in the third-to-last sentence of the abstract, now reading, in part, “we calculate a rate of 0.02–0.01 +0.04 Gpc–3 yr–1”, where Gpc was spelled out as gigapascals, not gigaparsecs. Also, the scale label (2″) was missing in the lower-left corner of Fig. 1b. The errors have been corrected in the HTML and PDF versions of the article.

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First-Principles Molecular Dynamics Study Of Liquid Iron-Rich Alloys Under Conditions Of The Earth’S Core, Dipendra Banjara Jan 2023

First-Principles Molecular Dynamics Study Of Liquid Iron-Rich Alloys Under Conditions Of The Earth’S Core, Dipendra Banjara

LSU Doctoral Dissertations

In this dissertation, we report the results of the first-principles molecular dynamics (FPMD) simulations and data analysis on the thermodynamic, structural, and transport properties of iron-rich metallic liquids considering several light and heavy elements under wide ranges of pressure and temperature that are relevant to the earth’s core. Our simulations of pure liquid iron cover the pressure range from 0 GPa at 2000 K to 380 GPa at 7000 K perhaps representing the most extensive computational study to date. We studied four molten iron-rich alloys corresponding to 2.67 atom% of Ni, Co, Mo, and W at pressures up to 380 …

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Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond Jan 2023

Controls Of Physical Drivers On The Formation And Toxicity Of Harmful Cyanobacteria Blooms (Cyanohabs), Courtney N. Hammond

LSU Master's Theses

Estuaries within the Gulf of Mexico are exhibiting profound alterations due to climatic changes and the implementation of coastal restoration activities. These changes are attributed to the increasing frequency of harmful cyanobacteria blooms (cyanoHABs) within Lake Pontchartrain, an estuary located in southeastern Louisiana, USA. There is a better understanding into how the opening of the Bonnet Carré Spillway (BCS) impacts cyanoHAB formations compared to the effect of other physical drivers when the spillway doesn’t dominate the system. The goal of this study is to provide a greater understanding of the baseline conditions when the BCS is closed and determine what …

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Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel Jan 2023

Development Of A Peptide-Based Protac Incorporating A Β-Hairpin Sequence, Hannah Catherine Hymel

LSU Doctoral Dissertations

The ubiquitin-proteasome system (UPS) is a biochemical pathway primarily responsible for the degradation of damaged proteins. The UPS is regulated by E3 ubiquitin ligases, which recognize specific degradation sequences, or degrons, on a protein leading to protein ubiquitination and subsequent degradation by the proteasome. Proteolysis targeting chimeras (PROTACs) have emerged as a novel therapeutic agent to selectively degrade ‘undruggable’ targets; however, many peptide-based PROTACs suffer low cell permeability and high protease susceptibility. The goal of this work is to utilize degron-based substrates that function as cell penetrating peptides (CPPs) in a PROTAC to selectively degrade a target. The first part …

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