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A Multi-Proxy Approach To Refining Paleotempestology Records On The Northern Gulf Of Mexico Coast, Marianne Elizabeth Dietz

LSU Doctoral Dissertations

Reconstructing pre-historic hurricane activity is typically accomplished through the analysis of sandy overwash deposits identified in coastal lake settings. This method has been used successfully in many parts of the world and can extend the hurricane record thousands of years into the past. However, this approach also has its limitations. This dissertation addresses some of the limitations associated with geologic proxies used to reconstruct hurricane landfalls in the absence of historic data and tests new proxies for the identification of hurricane-derived overwash deposits. Modern storm deposits from two sites on the northern Gulf of Mexico coast are analyzed in detail …

Atomic Force Microscopy Tip-Enhanced Laser Ablation, Fan Cao

LSU Doctoral Dissertations

In the present work, an apertureless atomic force microscope (AFM) tip-enhanced laser ablation (TELA) system was developed and investigated. An AFM was coupled to an optical parametric oscillator (OPO) wavelength tunable laser for sample ablation with a submicron sampling size. The AFM was used to image the surface and hold the AFM tip 10 nm above the sample surface. The AFM tip is coated with a layer of gold with a thickness of 35 nm. The incident laser wavelength was tuned in the visible and near-infrared (IR) region and focused on the AFM tip. With the tip-enhancement effect, ablation craters …

Etoxpred: A Machine Learning-Based Approach To Estimate The Toxicity Of Drug Candidates 11 Medical And Health Sciences 1115 Pharmacology And Pharmaceutical Sciences 03 Chemical Sciences 0305 Organic Chemistry 03 Chemical Sciences 0304 Medicinal And Biomolecular Chemistry, Limeng Pu, Misagh Naderi, Tairan Liu, Hsiao Chun Wu, Supratik Mukhopadhyay, Michal Brylinski

Faculty Publications

© 2019 The Author(s). Background: The efficiency of drug development defined as a number of successfully launched new pharmaceuticals normalized by financial investments has significantly declined. Nonetheless, recent advances in high-throughput experimental techniques and computational modeling promise reductions in the costs and development times required to bring new drugs to market. The prediction of toxicity of drug candidates is one of the important components of modern drug discovery. Results: In this work, we describe eToxPred, a new approach to reliably estimate the toxicity and synthetic accessibility of small organic compounds. eToxPred employs machine learning algorithms trained on molecular fingerprints to …

Trophodynamics And Mercury Bioaccumulation In Reef And Open-Ocean Fishes From The Bahamas With A Focus On Two Teleost Predators, Oliver N. Shipley, Cheng Shiuan Lee, Nicholas S. Fisher, Georgiana Burruss, Michael G. Frisk, Edward J. Brooks, Zachary C. Zuckerman, Achim D. Herrmann, Daniel J. Madigan

Faculty Publications

© Inter-Research 2019. Identifying prey resource pools supporting fish biomass can elucidate trophic pathways of pollutant bioaccumulation. We used multiple chemical tracers (carbon [δ 13 C] and nitrogen [δ 15 N] stable isotopes and total mercury [THg]) to identify trophic pathways and measure contaminant loading in upper trophic level fishes residing at a reef and open-ocean interface near Eleuthera in the Exuma Sound, The Bahamas. We focused predominantly on the trophic pathways of mercury bioaccumulation in dolphinfish Coryphaena hippurus and wahoo Acanthocybium solandri, 2 commonly consumed pelagic sportfish in the region. Despite residing within close proximity to productive and extensive …

Photo-Induced Remote C-H Functionalization And New Thioglycoside Donor Development For O-Glycosylation, Shaofu Du

LSU Doctoral Dissertations

This dissertation focuses on the method development of C-H functionalization using photo-redox catalysis and the synthesis of new thioglycoside donors towards O-glycosylation. Chapter 1 describes the remote Csp³-H functionalization using photo-redox catalysis. The site-selective and high-yielding conversion of unreactive aliphatic C-H bonds has been a challenge for organic chemists for many years. In this work, inert C-H bonds were successfully converted to more useful C-C, C-N, and C-O bonds via hydrogen atom transfer (HAT), radical translocation and polar crossover. This mechanistic manifold was enacted by visible-light irradiation of o-diazoniaphenyl alkyl sulfones in the presence of Ru(bpy) …

Toward The Impact Of Particulate Matter On Human Health: Evaluation Of Fluorescent Environmentally Persistent Free Radical (Epfr) Surrogates, Ansonia Badgett

LSU Doctoral Dissertations

Environmentally persistent free radicals (EPFRs)—a newly discovered pollutant associated with particulate matter (PM)—form during combustion and thermal processes, such as the incineration of hazardous waste. Various chlorine- and hydroxy-substituted benzenes chemisorb on the surface of metal oxides (e.g., NiO, CuO, and Fe₂O₃) and then form EPFRs, stabilized radical species, as the result of the transfer of electrons between the adsorbate and the metal ion of the metal oxide. Previous studies have shown direct correlations between ultra-fine (d < 0.1 mm) particulate matter (PM_0.1) exposure and adverse pulmonary health effects. PM_0.1 has the potential …

The Influence Of Selected Factors On The Perceived Work Readiness Of Undergraduate Program Completers At A Research University, Karen Lynne Goodridge

LSU Doctoral Dissertations

The primary purpose of this study was to determine the influence of selected personal, academic, and employment characteristics on the perceived work readiness of undergraduate program completers at a research university located in the Southern Region of the United States. The target population was undergraduate program completers at research universities in the United States. The accessible population was undergraduate program completers at one selected research university (RU/VH) located in the Southern Region of the United States. The sample comprised 100% of the defined accessible population who completed a graduating student survey administered by the Office of Career Services (OCS) at …

Effects Of Shoal Margin Collapses On The Morphodynamics Of A Sandy Estuary, M. R. Hiatt

Faculty Publications

Shoal margin collapses of several million cubic meters have occurred in the Western Scheldt estuary, the Netherlands, on average five times a year over the last decades. While these collapses involve significant volumes of material, their effect on the channel-shoal morphology is unknown. We hypothesize that collapses dynamicize the channel-shoal interactions, which could impact the ecological functioning, flood safety, and navigation in the estuary. The objective is to investigate how locations, probability, type, and volume of shoal margin collapse affect the channel-shoal dynamics. We implemented an empirically validated parameterization for shoal margin collapses and tested its effect on simulated estuary …

Advocating For Science: Amici Curiae Brief Of Wetland And Water Scientists In Support Of The Clean Water Rule, R C. Gardner, E Okuno, S Tai, M S. Fennessy, R C. Gardner, M L. Otte, M Palmer, J E. Perry, C Simenstad, B R. Tanner, D Tufford, R. Eugene Turner, K Work, S C. Yaich, J B. Zedler

Faculty Publications

The Trump administration has proposed replacing the Clean Water Rule, a 2015 regulation that defined the statutory term waters of the United States to clarify the geographic jurisdiction of the Clean Water Act. Since its promulgation, the Clean Water Rule has been subjected to numerous judicial challenges. We submitted an amici curiae brief to the United States Court of Appeals for the Sixth Circuit, explaining why the Clean Water Rule, and its definition of waters of the United States, is scientifically sound. The definition of waters of the United States is a legal determination informed by science. The best available …

A Comprehensive Evaluation Of Predictive Performance Of 33 Species Distribution Models At Species And Community Levels, Anna Norberg, Nerea Abrego, F. Guillaume Blanchet, Frederick R. Adler, Barbara J. Anderson, Jani Anttila, Miguel B. Araújo, Tad Dallas, David Dunson, Jane Elith, Scott D. Foster, Richard Fox, Janet Franklin, William Godsoe, Antoine Guisan, Bob O'Hara, Nicole A. Hill, Robert D. Holt, Francis K.C. Hui, Magne Husby, John Atle Kålås, Aleksi Lehikoinen, Miska Luoto, Heidi K. Mod, Graeme Newell, Ian Renner, Tomas Roslin, Janne Soininen, Wilfried Thuiller, Jarno Vanhatalo, David Warton, Matt White, Niklaus E. Zimmermann

Faculty Publications

© 2019 The Authors. Ecological Monographs published by Wiley Periodicals, Inc. on behalf of Ecological Society of America A large array of species distribution model (SDM) approaches has been developed for explaining and predicting the occurrences of individual species or species assemblages. Given the wealth of existing models, it is unclear which models perform best for interpolation or extrapolation of existing data sets, particularly when one is concerned with species assemblages. We compared the predictive performance of 33 variants of 15 widely applied and recently emerged SDMs in the context of multispecies data, including both joint SDMs that model multiple …

Fluorescence-Based Ratiometric Nanosensor For Selective Imaging Of Cancer Cells, Isiah M. Warner, Kelsey E. Mcneel, Noureen Siraj, Nimisha Bhattarai

Faculty Publications

Herein, we report the synthesis and characterization of a nanosensor developed from a group of uniform materials based on organic salts (GUMBOS). This sensor is composed of three ionic species, namely, fluorescein, rhodamine B, and tetradecyltrihexyl phosphonium (P-66614) ions. Nanoparticles prepared from this three-component GUMBOS, termed nanoGUMBOS, exhibited increased fluorescence at two wavelengths with increases in pH values. The ratio of fluorescence emission corresponding to FL and RhB components of these nanoGUMBOS also changed with pH, allowing ratiometric analysis of pH through fluorescence measurements. Peak ratios were significantly different at pH 5 and pH 7, indicating potential applications of this …

Synthesis And Investigation Of Phthalocyanine-Biotin Conjugates, M. Graca H. Vicente, Elizabeth A. Okoth, Zehua Zhou, Benson Ongarora

Faculty Publications

An isothiocyanato-functionalized phthalocyanine (Pc) was synthesized in good yield from the corresponding amine-substituted Pc. This Pc reacted with ethanolamine, biotin hydrazine, and biotin diethylamine under mild conditions (room temperature in DMF or DMSO in the presence of TEA) to produce the corresponding thiourea products in 60-75% yields. All Pcs showed intense Q absorptions in DMF around 677 nm, emissions centered at 683 nm, and fluorescence quantum yields in the range 0.18-0.27. The Pcs were phototoxic to human carcinoma HEp2 cells (IC50 similar to 7 at 1.5 J/cm(2)) and localized in multiple organelles, including the lysosomes, Golgi and ER. One biotin-Pc …

Multidimensional Poverty Of The Ethnic Tibetan Farm And Herder Households In Gansu Province, China, Fan Yang, Krishna Paudel, Tianhui Zhuang, Yao Jiang

Faculty Publications

© 2019, Universidade Federal de Santa Maria. All rights reserved. Ethnic Tibetan farm and herder households (FHH) in Gansu Province, China are stricken with poverty. Solving the poverty problem in this or other poverty pockets across China has special importance for the country’s political stability, ethnic unity, social well-being, and ecological security. This paper calculates the multidimensional poverty situation of ethnic Tibetan farm and herder households of Gansu Province, China by using the Alkire-Foster method. Twelve indicators are included in the multidimensional poverty indicator system. Results showed that 1) in the single indicator measure, the adult family members received at …

Union Bound For Quantum Information Processing, Samad Khabbazi Oskouei, Stefano Mancini, Mark M. Wilde

Faculty Publications

In this paper, we prove a quantum union bound that is relevant when performing a sequence of binary-outcome quantum measurements on a quantum state. The quantum union bound proved here involves a tunable parameter that can be optimized, and this tunable parameter plays a similar role to a parameter involved in the Hayashi–Nagaoka inequality (Hayashi & Nagaoka 2003 IEEE Trans. Inf. Theory 49, 1753–1768. (doi:10.1109/TIT.2003.813556)), used often in quantum information theory when analysing the error probability of a square-root measurement. An advantage of the proof delivered here is that it is elementary, relying only on basic properties of projectors, Pythagoras’ …

Normal Tissue Damage: Its Importance, History And Challenges For The Future, Jacqueline P. Williams, Wayne Newhauser

Faculty Publications

Sir Oliver Scott, a philanthropist and radiation biologist and, therefore, the epitome of a gentleman and a scholar, was an early Director of the BECC Radiobiology Research Unit at Mount Vernon. His tenure preceded that of Jack Fowler, with both contributing to basic, translational and clinical thought and application in radiation across the globe. With respect to this review, Fowler's name in particular has remained synonymous with the use of models, both animal and mathematical, that assess and quantify the biological mechanisms that underlie radiation-associated normal tissue toxicities. An understanding of these effects is critical to the optimal use of …

Kojima-1lb Is A Mildly Cold Neptune Around The Brightest Microlensing Host Star, A. Fukui, D. Suzuki, N. Koshimoto, E. Bachelet, T. Vanmunster, D. Storey, H. Maehara, K. Yanagisawa, T. Yamada, A. Yonehara, T. Hirano, D. P. Bennett, V. Bozza, D. Mawet, M. T. Penny, S. Awiphan, A. Oksanen, T. M. Heintz, T. E. Oberst, V. J.S. Béjar, N. Casasayas-Barris, G. Chen, N. Crouzet, D. Hidalgo, P. Klagyivik, F. Murgas, N. Narita, E. Palle, H. Parviainen, N. Watanabe, N. Kusakabe, M. Mori, Y. Terada

Faculty Publications

We report the analysis of additional multiband photometry and spectroscopy and new adaptive optics (AO) imaging of the nearby planetary microlensing event TCPJ05074264+2447555 (Kojima-1), which was discovered toward the Galactic anticenter in 2017 (Nucita et al.). We confirm the planetary nature of the light-curve anomaly around the peak while finding no additional planetary feature in this event. We also confirm the presence of apparent blending flux and the absence of significant parallax signal reported in the literature. The AO image reveals no contaminating sources, making it most likely that the blending flux comes from the lens star. The measured multiband …

A Fast Approximate Approach To Microlensing Survey Analysis, Somayeh Khakpash, Matthew Penny, Joshua Pepper

Faculty Publications

Microlensing can be used to discover exoplanets of a wide range of masses with orbits beyond ∼1 au, and even free-floating planets. The Wide Field Infrared Survey Telescope (WFIRST) mission will use microlensing to discover approximately 1600 planets by monitoring ∼100 million stars to find ∼50,000 microlensing events. Modeling each microlensing event, especially the ones involving two or more lenses, is typically complicated and time consuming, and analyzing thousands of WFIRST microlensing events is possibly infeasible using current methods. Here, we present an algorithm that is able to rapidly evaluate thousands of simulated WFIRST binary-lens microlensing light curves, returning an …

The Equivalence Principle At Work In Radiation From Unaccelerated Atoms And Mirrors, S. A. Fulling, J. H. Wilson

Faculty Publications

The equivalence principle is a perennial subject of controversy, especially in connection with radiation by a uniformly accelerated classical charge, or a freely falling charge observed by a supported detector. Recently, related issues have been raised in connection with the Unruh radiation associated with accelerated detectors (including two-level atoms and resonant cavities). A third type of system, very easy to analyze because of conformal invariance, is a two-dimensional scalar field interacting with perfectly reflecting boundaries (mirrors). After reviewing the issues for atoms and cavities, we investigate a stationary mirror from the point of view of an accelerated detector in 'Rindler …

Spatiotemporal Coupling Of Attosecond Pulses, Hampus Wikmark, Chen Guo, Jan Vogelsang, Peter W. Smorenburg, Hélène Coudert-Alteirac, Jan Lahl, Jasper Peschel, Piotr Rudawski, Hugo Dacasa, Stefanos Carlström, Sylvain Maclot, Mette B. Gaarde, Per Johnsson, Cord L. Arnold, Anne L'Huillier

Faculty Publications

The shortest light pulses produced to date are of the order of a few tens of attoseconds, with central frequencies in the extreme UV range and bandwidths exceeding tens of electronvolts. They are often produced as a train of pulses separated by half the driving laser period, leading in the frequency domain to a spectrum of high, odd-order harmonics. As light pulses become shorter and more spectrally wide, the widely used approximation consisting of writing the optical waveform as a product of temporal and spatial amplitudes does not apply anymore. Here, we investigate the interplay of temporal and spatial properties …

Ecogeographical Rules And The Macroecology Of Food Webs, Benjamin Baiser, Dominique Gravel, Alyssa R. Cirtwill, Jennifer A. Dunne, Ashkaan K. Fahimipour, Luis J. Gilarranz, Joshua A. Grochow, Daijiang Li, Neo D. Martinez, Alicia Mcgrew, Timothée Poisot, Tamara N. Romanuk, Daniel B. Stouffer, Lauren B. Trotta, Fernanda S. Valdovinos, Richard J. Williams, Spencer A. Wood, Justin D. Yeakel

Faculty Publications

© 2019 John Wiley & Sons Ltd Aim: How do factors such as space, time, climate and other ecological drivers influence food web structure and dynamics? Collections of well-studied food webs and replicate food webs from the same system that span biogeographical and ecological gradients now enable detailed, quantitative investigation of such questions and help integrate food web ecology and macroecology. Here, we integrate macroecology and food web ecology by focusing on how ecogeographical rules [the latitudinal diversity gradient (LDG), Bergmann's rule, the island rule and Rapoport's rule] are associated with the architecture of food webs. Location: Global. Time period: …

Research At Cct (2019), Lsu Center For Computation And Technology

Components

No abstract provided.

Lsu General Catalog 2019-2020, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

Examining The Interaction Of State And Trait Anxiety On Working Memory Performance, Carly C. Moore

Honors Capstones

No abstract provided.

Using A Neonatal Model Of Recombinant Inbred Mice To Identify Quantitative Trait Loci Underlying Variation In Host Permissiveness To Hrsv Load, Scotty Alexander

Honors Capstones

No abstract provided.

Random Matrices, Continuous Circular Systems And The Triangular Operator, Romuald Lenczewski

Communications on Stochastic Analysis

No abstract provided.

Exponential Inequalities For Exit Times For Stochastic Navier-Stokes Equations And A Class Of Evolutions, Po-Han Hsu, Padamanbhan Sundar

Communications on Stochastic Analysis

No abstract provided.

Global Strong Solutions Of The Stochastic Three Dimensional Inviscid Simplified Bardina Turbulence Model, Manil T. Mohan

Communications on Stochastic Analysis

No abstract provided.

Normally Ordered Disentanglement Of Multi-Dimensional Schrödinger Algebra Exponentials, Luigi Accardi, Andreas Boukas

Communications on Stochastic Analysis

No abstract provided.

Bibliometrics For Faculty Evaluation: A Statistical Comparison Of H-Indexes Generated Using Google Scholar And Web Of Science Data, David J. Dunaway

Faculty Publications

The growing need for quantification of research performance for promotion and tenure

and grant funding decisions has lead many to rely on citation metrics. There are many metrics to choose from but one of the most common is the h-index. While the h-index has been criticized by many, the metric itself is not the only concern. The source of the citation information used to calculate the h-index is also important. In this case study the h-index was calculated using citation data from Clarivate’s Web of Science (WoS) and Google Scholar (GS) for a selection of faculty working at a large …

Quantifying Amphibian Range Fragmentation In The Southeastern United States, Catherine E. Newman, Christopher C. Austin

Faculty Publications

© the authors. An often overlooked component of research on factors that drive amphibian geographic distributions is description of species range shape. Broad-scale range disjunction has implications for phylogeography, ecology, and conservation, but descriptions of fragmentation are usually based on subjective visual assessment of range maps. Here, we describe a method for objectively quantifying range fragmentation and use this method to describe the patterns of amphibian species range shapes in the southeastern United States, home to the highest amphibian species richness in North America. Species ranges varied widely in degree of fragmentation, from completely contiguous to highly fragmented, and degree …