Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Louisiana State University

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 571 - 600 of 819

Full-Text Articles in Entire DC Network

Functional And Physical Interactions Of The Herpes Simplex Virus Type 1 Ul20 Membrane Protein With Glycoprotein K, Timothy P. Foster, Vladimir N. Chouljenko, K. G. Kousoulas Jul 2008

Functional And Physical Interactions Of The Herpes Simplex Virus Type 1 Ul20 Membrane Protein With Glycoprotein K, Timothy P. Foster, Vladimir N. Chouljenko, K. G. Kousoulas

Faculty Publications

Herpes simplex virus type 1 glycoprotein K (gK) and the UL20 protein (UL20p) are coordinately transported to the trans-Golgi network (TGN) and cell surfaces and are required for cytoplasmic virion envelopment at the TGN. In addition, cell surface expression of gK and UL20p is required for virus-induced cell fusion. Previously, confocal microscopy colocalization and intracellular transport experiments strongly suggested direct protein-protein interactions between gK and UL20p. Direct protein-protein interactions between gK and UL20p were demonstrated through reciprocal coimmunoprecipitation experiments, as well as with glutathione S-transferase (GST) pull-down experiments. A fusion protein consisting of the amino-terminal 66 amino acids of UL20p …

Go to article

Identification Of Rickettsia Felis In The Salivary Glands Of Cat Fleas, Kevin R. Macaluso, Walairat Pornwiroon, Vsevolod L. Popov, Lane D. Foil Jun 2008

Identification Of Rickettsia Felis In The Salivary Glands Of Cat Fleas, Kevin R. Macaluso, Walairat Pornwiroon, Vsevolod L. Popov, Lane D. Foil

Faculty Publications

Rickettsia felis, a flea-associated rickettsial pathogen, has been identified in many tissues, including the digestive and reproductive tissues, within the cat flea, Ctenocephalides felis. We utilized transmission electron microscopy and polymerase chain reaction to identify R. felis in the salivary glands of fed fleas and further define the distribution of R. felis within the arthropod host. We identified Rickettsia-like organisms in salivary glands using electron microscopy. Sequence analysis of portions of the Rickettsia genus-specific 17-kDa antigen gene and R. felis plasmid confirmed the morphological identification of R. felis in cat flea salivary glands. This is the first report of R. …

Go to article

The Innate Immune Database (Iidb), Martin Korb, G. R. Aistair, Vesteinn Thorsson, Christophe Battail, Bin Li, Daehee Hwang, Kathleen A. Kennedy, Jared C. Roach, Carrie M. Rosenberger, Mark Gilchrist, Daniel Zak, Carrie Johnson, Bruz Marzolf, Alan Aderem, Ilya Shmulevich, Hamid Bolouri Mar 2008

The Innate Immune Database (Iidb), Martin Korb, G. R. Aistair, Vesteinn Thorsson, Christophe Battail, Bin Li, Daehee Hwang, Kathleen A. Kennedy, Jared C. Roach, Carrie M. Rosenberger, Mark Gilchrist, Daniel Zak, Carrie Johnson, Bruz Marzolf, Alan Aderem, Ilya Shmulevich, Hamid Bolouri

Faculty Publications

Background: As part of a National Institute of Allergy and Infectious Diseases funded collaborative project, we have performed over 150 microarray experiments measuring the response of C57/BL6 mouse bone marrow macrophages to toll-like receptor stimuli. These microarray expression profiles are available freely from our project web site http://www.innateImmunity-systemsbiology.org. Here, we report the development of a database of computationally predicted transcription factor binding sites and related genomic features for a set of over 2000 murine immune genes of interest. Our database, which includes microarray co-expression clusters and a host of web-based query, analysis and visualization facilities, is available freely via the …

Go to article

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem Feb 2008

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem

Faculty Publications

No abstract provided.

Go to article

Uncovering A Macrophage Transcriptional Program By Integrating Evidence From Motif Scanning And Expression Dynamics, Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich Jan 2008

Uncovering A Macrophage Transcriptional Program By Integrating Evidence From Motif Scanning And Expression Dynamics, Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich

Faculty Publications

Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In response to microbial challenge, the TLR-stimulated macrophage undergoes an activation program controlled by a dynamically inducible transcriptional regulatory network. Mapping a complex mammalian transcriptional network poses significant challenges and requires the integration of multiple experimental data types. In this work, we inferred a transcriptional network underlying TLR-stimulated murine macrophage activation. Microarray-based expression profiling and transcription factor binding site motif scanning were used to infer a network of associations between transcription factor genes and clusters of co-expressed target genes. The time-lagged …

Go to article

Two Post-Harvest Treatments For The Reduction Of Vibrio Vulnificus And Vibrio Parahaemolyticus In Eastern Oysters (Crassostrea Virginica), Kevin Patrick Melody Jan 2008

Two Post-Harvest Treatments For The Reduction Of Vibrio Vulnificus And Vibrio Parahaemolyticus In Eastern Oysters (Crassostrea Virginica), Kevin Patrick Melody

LSU Master's Theses

Vibrio vulnificus and V. parahaemolyticus are naturally occurring estuarine bacteria and the leading causes of seafood-borne illness in the United States. Multiple outbreaks due to raw oyster consumption in the last decade has lead to much research to remediate these bacteria from oysters destined for the half-shell market. The focus of this research was to investigate the efficacy of icing and high salinity exposure as two post-harvest treatments for the reduction in numbers of V. vulnificus and V. parahaemolyticus in commercial quantities of shellstock oysters. The icing experiment was conducted in the summer of 2006, and the high salinity trials …

Go to article

Characterizing The Epidemiology Of Bluetongue Virus Serotype One In South Louisiana, Michael Edward Becker Jan 2008

Characterizing The Epidemiology Of Bluetongue Virus Serotype One In South Louisiana, Michael Edward Becker

LSU Master's Theses

In November 2004, bluetongue virus (BTV) serotype 1 was detected for the first time in the U.S. from a hunter-killed deer in the marsh area of the Atchafalaya Delta in St. Mary Parish, LA. Subsequent serum surveys of three cattle farms further inland from the area where the deer was shot found bluetongue virus serotype 1 positive cattle on two of the three farms. The purpose of this study was to determine potential BTV vectors in the area where BTV-1 positive animals were detected and compare different trapping techniques for capturing specimens of the genus Culicoides. The study was conducted …

Go to article

Medical Geography In Public Health And Tropical Medicine: Case Studies From Brazil, William Brennan Arden Jan 2008

Medical Geography In Public Health And Tropical Medicine: Case Studies From Brazil, William Brennan Arden

LSU Doctoral Dissertations

Within the last few decades, the multitude of infrastructural and environmental changes associated with population growth, human migration, and economic development have catalyzed the emergence and re-emergence of many infectious diseases worldwide. The morbidity and mortality associated with these diseases have in turn led to an increased and renewed impetus to gain a better understanding of the etiology, epidemiology, prevention, and control of these diseases in order to achieve better health and well-being, especially for underprivileged populations. Two traditionally separate fields, medical geography and tropical medicine, have recently seen complex and radical paradigm shifts in response to this global situation: …

Go to article

Neonatal Respiratory Virus Infection Shapes Pulmonary Function In Adult Mice, Dahui You Jan 2008

Neonatal Respiratory Virus Infection Shapes Pulmonary Function In Adult Mice, Dahui You

LSU Doctoral Dissertations

Respiratory syncytial virus (RSV) and influenza are the two most common causes of acute lower respiratory tract infections in infants. Epidemiological data suggest that both severe RSV and influenza infections during infancy are associated with long-term pulmonary function abnormalities. Despite of the severe burdens of RSV and influenza infections in infants, no efficacious vaccines are available for RSV and the current vaccine strategy for influenza is inconvenient due to the fact that vaccines are made annually based on the prediction of circulating strains in the next season. New strategies in vaccine development have been slow to arrive partly due to …

Go to article

Factors Potentially Influencing The Abundance Of Mosquitoes In Louisiana Rice Fields, Ana Maria Sanchez De Cuadra Jan 2008

Factors Potentially Influencing The Abundance Of Mosquitoes In Louisiana Rice Fields, Ana Maria Sanchez De Cuadra

LSU Master's Theses

The rice stink bug (Oebalus pugnax) is the major pest of late-season rice in Louisiana. Prior studies indicate that large populations of mosquitoes are often present in rice fields during the time that rice fields are infested with rice stink bugs. Lambda-cyhalothrin (Karate®) is widely used to control rice stink bugs. The purpose of this study was to determine if application of the insecticide Karate® at a rate of 0.033 kg/ha, for rice stink bug control had an effect on the population of mosquitoes in rice fields. This effect was assessed by monitoring natural populations of mosquitoes before and after …

Go to article

Randomized Controlled Trial Evaluating Adeno-Momp And Momp Dna Vaccines Against Chlamydophila Psittaci Challenge In Cockatiels (Nymphicus Hollandicus), David Sanchez-Migallon Guzman Jan 2008

Randomized Controlled Trial Evaluating Adeno-Momp And Momp Dna Vaccines Against Chlamydophila Psittaci Challenge In Cockatiels (Nymphicus Hollandicus), David Sanchez-Migallon Guzman

LSU Master's Theses

Chlamydophila psittaci causes severe disease in birds and humans, and important economical losses in the avian companion and poultry industry. Vaccines are the most cost-effective measure to control and help prevent infectious diseases, but to date there is no commercial vaccine available. A randomized clinical trial was conducted to assess the efficacy of two recombinant DNA vaccines against C. psittaci in Cockatiels (Nymphicus hollandicus). The first recombinant DNA vaccine has a gene encoding MOMP and the immunostimulant chitosan (MOMP DNA vaccine). The second recombinant DNA vaccine, contained the gene encoding MOMP that was vectored by a replication defective human adenovirus …

Go to article

Native Spiritualities As Resistance: Disrupting Colonialism In The Americas, Kirstin Lea Squint Jan 2008

Native Spiritualities As Resistance: Disrupting Colonialism In The Americas, Kirstin Lea Squint

LSU Doctoral Dissertations

This project analyzes eight novels which represent revolt or resistance by varied Native peoples against the European and Euro-American colonization of the Americas. I take a comparative approach to literatures of the Americas because of the dearth of research examining the literatures of both continents side by side, particularly literatures by and about Indigenous Americans. Chapter One introduces the theoretical bases for the project, including colonial and postcolonial theories, Native American literary theories, and aesthetic concerns specific to American Indian literatures. The second chapter is a comparative analysis of Miguel Angel Asturias’s Men of Maize and Leslie Marmon Silko’s Almanac …

Go to article

Evidence Of Pulmonary Disease In The Poole-Rose Ossuary Population: An Analysis Of The Ribs, Lisa Elaine Baumer Jan 2008

Evidence Of Pulmonary Disease In The Poole-Rose Ossuary Population: An Analysis Of The Ribs, Lisa Elaine Baumer

LSU Master's Theses

This study reports on the demographics and evidence of pulmonary disease in the Poole-Rose Ossuary which was excavated in 1990 under the direction of Heather McKillop. The bones are being studied at the request of the Alderville First Nation. Radiocarbon dated to A.D. 1550 ± 50 years, the skeletal material is a co-mingled collection that is consistent with a mass secondary burial event known as the Feast of the Dead often associated with the Huron. The ribs were used in this study. The condition of the ribs was highly fragmented. The minimum number of individuals for this study was 49 …

Go to article

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For The Analysis Of Collected Bioaerosols, Alton John Dugas Jan 2008

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For The Analysis Of Collected Bioaerosols, Alton John Dugas

LSU Doctoral Dissertations

The goal of this dissertation was to demonstrate collection, detection and identification of microorganisms from bioaerosols using offline matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for the analysis of proteins. MALDI-MS intact bacteria techniques were adapted for use with an orthogonal MALDI quadrupole-time-of-flight mass spectrometer. Results indicate the instrument is capable of analyzing intact whole-cells. The first phase was to evaluate three bioaerosol samplers, an Andersen N6 single-stage impactor (AI), a cyclone impactor, and a vacuum filter system. The samplers collected test bioaerosols using a constructed bioaerosol exposure chamber (BEC). The BEC allowed all three samplers to operate in parallel. Each …

Go to article

Neuropsychological Performance And Dementia Symptoms In A Hiv Positive Population, Kathleen E. Kendra Jan 2008

Neuropsychological Performance And Dementia Symptoms In A Hiv Positive Population, Kathleen E. Kendra

LSU Doctoral Dissertations

Acquired immune deficiency syndrome (AIDS) is an infectious disease caused by human immunodeficiency virus (HIV), which affects millions of individuals worldwide. This syndrome is associated with many medical complications. Fortunately, patients with HIV and AIDS have longer life expectancy than in past decades with HIV and AIDS; however, the risk of cognitive impairment is greater in this population. Identification of dementia due to HIV/AIDS by health care professionals is hampered by the unclear relationship between cognitive functioning and HIV-related health status in the HIV/AIDS research literature. For the current study, individuals with HIV/AIDS who are symptomatic with infection but do …

Go to article

Durable And Reusable Antimicrobial Textiles, Leila Elizabeth Bonin Jan 2008

Durable And Reusable Antimicrobial Textiles, Leila Elizabeth Bonin

LSU Master's Theses

Antimicrobial textiles are a large research focus in the textile industry. There is an apparent need for creating reusable and durable antimicrobial textiles. Most of the textiles with antimicrobial properties effective against Staphylococcus aureus are disposable. To address the issue, two types of biopolymer solutions were created in a USDA lab. Both solutions displayed antimicrobial properties. A medium weight, plain weave cotton sheeting was used as the test fabric. Samples of the sheeting were cut, treated, and tested to determine their efficacy as antimicrobial textiles. The tests performed included tensile deformation, bending, shearing, compression, surface friction, surface roughness, and treatment …

Go to article

An Evaluation Of The Perceived Obstacles For Policy Officials Regulating The Post Harvest Treatment Of Raw Oysters To Control The Human Health Vibrio Vulnificus Problem, Amy Leah Oestringer Jan 2008

An Evaluation Of The Perceived Obstacles For Policy Officials Regulating The Post Harvest Treatment Of Raw Oysters To Control The Human Health Vibrio Vulnificus Problem, Amy Leah Oestringer

LSU Master's Theses

Vibrio vulnificus is the leading pathogen linked to seafood-associated deaths. This naturally occurring marine bacterium presents a human health risk when it is consumed in raw oysters. Hospitalization is necessary in 90 % Vibrio vulnificus illnesses and 40% end in death. (CDC) Several guidelines and regulations have been enacted to combat this human health issue, but have failed to reduce the steadily rising illness rate. Post-harvest processing requirements for raw oysters could be used to reduce illness rates. A survey was conducted to measure the perceived obstacles that regulators and industry representatives of the raw oyster industry face in policymaking …

Go to article

The Herpes Simplex Virus Ul20 Protein Functions In Glycoprotein K (Gk) Intracellular Transport And Virus-Induced Cell Fusion Are Independent Of Ul20 Functions In Cytoplasmic Virion Envelopment, Jeffrey M. Melancon, Preston A. Fulmer, Konstantin G. Kousoulas Dec 2007

The Herpes Simplex Virus Ul20 Protein Functions In Glycoprotein K (Gk) Intracellular Transport And Virus-Induced Cell Fusion Are Independent Of Ul20 Functions In Cytoplasmic Virion Envelopment, Jeffrey M. Melancon, Preston A. Fulmer, Konstantin G. Kousoulas

Faculty Publications

The HSV-1 UL20 protein (UL20p) and glycoprotein K (gK) are both important determinants of cytoplasmic virion morphogenesis and virus-induced cell fusion. In this manuscript, we examined the effect of UL20 mutations on the coordinate transport and Trans Golgi Network (TGN) localization of UL20p and gK, virus-induced cell fusion and infectious virus production. Deletion of 18 amino acids from the UL20p carboxyl terminus (UL20 mutant 204t) inhibited intracellular transport and cell-surface expression of both gK and UL20, resulting in accumulation of UL20p and gK in the endoplasmic reticulum (ER) in agreement with the inability of 204t to complement UL20-null virus replication …

Go to article

Conferred Immunity Against The H1n1 Type A Influenza Virus In Madin-Darby Canine Kidney Cells Via Cecropin B Transfection Therapy., Tomasz P. Stryjewski Nov 2007

Conferred Immunity Against The H1n1 Type A Influenza Virus In Madin-Darby Canine Kidney Cells Via Cecropin B Transfection Therapy., Tomasz P. Stryjewski

Honors Capstones

No abstract provided.

Go to article

Epitope Mapping Of Hsv-1 Glycoprotein K (Gk) Reveals A T Cell Epitope Located Within The Signal Domain Of Gk, Yanira Osorio, Kevin R. Mott, Abdul M. Jabbar, Alberto Moreno, Timothy P. Foster, Konstantin G. Kousoulas, Homayon Ghiasi Sep 2007

Epitope Mapping Of Hsv-1 Glycoprotein K (Gk) Reveals A T Cell Epitope Located Within The Signal Domain Of Gk, Yanira Osorio, Kevin R. Mott, Abdul M. Jabbar, Alberto Moreno, Timothy P. Foster, Konstantin G. Kousoulas, Homayon Ghiasi

Faculty Publications

Glycoprotein K (gK) is a virion envelope component of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), which plays an important role in virion morphogenesis and egress. We previously demonstrated that immunization of mice with gK, but not with any of the 10 other HSV-1 glycoproteins, resulted in exacerbation of corneal scarring and herpetic dermatitis following ocular HSV-1 infection. However, little is known about the gK epitope(s) that is (are) involved in T cell activities in vitro or in vivo. Thus, epitope mapping of gK was performed using a panel of 15-mer peptides with five-amino acid overlaps spanning the …

Go to article

Comparative Microbiota Of Rickettsia Felis-Uninfected And -Infected Colonized Cat Fleas, Ctenocephalides Felis, Walairat Pornwiroon, Michael T. Kearney, Claudia Husseneder, Lane D. Foil, Kevin R. Macaluso Sep 2007

Comparative Microbiota Of Rickettsia Felis-Uninfected And -Infected Colonized Cat Fleas, Ctenocephalides Felis, Walairat Pornwiroon, Michael T. Kearney, Claudia Husseneder, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Fleas serve as arthropod vectors for several emerging and re-emerging infectious disease causing agents including, Rickettsia felis. Although the prevalence of R. felis infection in colonies of fleas has been examined, the influence of the R. felis infection on flea microbiota has not been investigated. We identified three colonies of cat fleas, Ctenocephalides felis, with varying prevalence of R. felis infection (Louisiana State University (LSU), 93.8; Professional Laboratory and Research Services Inc. (PLRS), 16.4; Elward II (EL), 0) and subsequently utilized polymerase chain reaction amplification, restriction fragment length polymorphism analysis and sequencing of the 1.4-kb portions of 16S rRNA genes …

Go to article

Erratum: Avian Influenza (H5n1) And The Evolutionary And Social Ecology Of Infectious Disease Emergence (Ecohealth (September 2006) 3:3 (187-194) Doi: 10.1007/S10393-006-0044-6), Durrell D. Kapan, Shannon N. Bennett, Brett R. Ellis, Jefferson Fox, Nancy D. Lewis, James H. Spencer, Sumeet Saksena, Bruce A. Wilcox Jun 2007

Erratum: Avian Influenza (H5n1) And The Evolutionary And Social Ecology Of Infectious Disease Emergence (Ecohealth (September 2006) 3:3 (187-194) Doi: 10.1007/S10393-006-0044-6), Durrell D. Kapan, Shannon N. Bennett, Brett R. Ellis, Jefferson Fox, Nancy D. Lewis, James H. Spencer, Sumeet Saksena, Bruce A. Wilcox

Faculty Publications

No abstract provided.

Go to article

Induction Of Host Chemotactic Response By Encephalitozoon Spp., Jeffrey Fischer, Jeffrey West, Nnenaya Agochukwu, Colby Suire, Hollie Hale-Donze Apr 2007

Induction Of Host Chemotactic Response By Encephalitozoon Spp., Jeffrey Fischer, Jeffrey West, Nnenaya Agochukwu, Colby Suire, Hollie Hale-Donze

Faculty Publications

Microsporidians are a group of emerging pathogens typically associated with chronic diarrhea in immunocompromised individuals. The number of reports of infections with these organisms and the disseminated pathology is growing as diagnostic tools become more readily available. However, little is known about the innate immune response induced by and generated against these parasites. Using a coculture chemotaxis system, primary human macrophages were infected with Encephalitozoon cuniculi or Encephalitozoon intestinalis, and the recruitment of naïve monocytes was monitored. Encephalitozoon spp. induced an average threefold increase in migration of naïve cells 48 h postinfection, which corresponded to optimal infection of monocyte-derived- macrophages. …

Go to article

Mobile Element-Based Forensic Genomics, David A. Ray, Jerilyn A. Walker, Mark A. Batzer Mar 2007

Mobile Element-Based Forensic Genomics, David A. Ray, Jerilyn A. Walker, Mark A. Batzer

Faculty Publications

Mobile elements are commonly referred to as selfish repetitive DNA sequences. However, mobile elements represent a unique and underutilized group of molecular markers. Several of their characteristics make them ideally suited for use as tools in forensic genomic applications. These include their nature as essentially homoplasy-free characters, they are identical by descent, the ancestral state of any insertion is known to be the absence of the element, and many mobile element insertions are lineage specific. In this review, we provide an overview of mobile element biology and describe the application of certain mobile elements, especially the SINEs and other retrotransposons, …

Go to article

Hurricane Andrew And Pregnancies In Louisiana, Anzhelika Antipova Jan 2007

Hurricane Andrew And Pregnancies In Louisiana, Anzhelika Antipova

LSU Master's Theses

There are anecdotal accounts about the possible impact of a pregnant woman's mental health on her unborn fetus. This thesis investigates the possible association between hurricane-related stress experienced by pregnant women living in the area afflicted by Hurricane Andrew in Louisiana in 1992 and poor pregnancy outcomes such as preterm and Low Birth Weight (LBW) births. This is an important topic of research because by investigating past events one can better understand the pregnancy-related health issues for areas affected by extreme weather events such as Hurricanes Katrina and Rita. This research analyzed birth data from Louisiana both before and after …

Go to article

The Black Death And Its Effect On Fourteenth- And Fifteenth-Century Art, Anna Louise Desormeaux Jan 2007

The Black Death And Its Effect On Fourteenth- And Fifteenth-Century Art, Anna Louise Desormeaux

LSU Master's Theses

In early October of 1347, ships from Caffa docked at the port of Messina in Sicily. The traders brought with them a fierce plague that swept through Europe from 1348 to 1352. This pandemic, which killed approximately half of Europe's population, came to be known as the Black Death. The fear propagated by the spread of the plague and its cyclical recurrence greatly affected the art created in Europe over the next 150 years. Accounts of victims of the plague and other contemporary documents, such as medical treatises, give modern readers a glimpse into the psyche of medieval people. These …

Go to article

Reevaluating Age In Subadult Remains In Response To Secular Changes In Skeletal Growth, Katherine Ann Blackwelder Jan 2007

Reevaluating Age In Subadult Remains In Response To Secular Changes In Skeletal Growth, Katherine Ann Blackwelder

LSU Master's Theses

The goal of forensic anthropology is the analysis and identification of human skeletal remains in a medicolegal context (Byers 2005:1-2). A forensic anthropologist can determine the age of subadult remains by various means, including dentition, centers of ossification, cranial suture closure, and epiphyseal union. Epiphyseal union is when all bones have completed their growth and fused, which happens for all bones by early adulthood. In this way, a forensic anthropologist can analyze the extent of epiphyseal union to determine the age of a deceased individual. This is done by comparing the skeletal remains to age-specific x-ray images of bones featured …

Go to article

Depletion Of 32-Kbp Circular Plasmids From Borrelia Burgdorferi, Amanda Paige Derouen Polito Jan 2007

Depletion Of 32-Kbp Circular Plasmids From Borrelia Burgdorferi, Amanda Paige Derouen Polito

LSU Master's Theses

The Lyme disease spirochete Borrelia burgdorferi has a very unusual genome composed of one linear chromosome and up to 21 linear and circular plasmids. Several plasmids are known to be important either for mammalian infection or tick colonization. A single spirochete harbors up to 7 different cp32 plasmids; however, nothing is known about their role in mammalian infection. The plasmids in this family are well maintained during in vitro cultivation, making it difficult to study their functions. To effectively deplete the plasmids, an 8kbp fragment containing essential elements for replication and partitioning in B. burgdorferi was amplified from one of …

Go to article

Detection Of Vibrio Vulnificus By Direct Colony Immunoblot, Reshani Nisansala Senevirathne Jan 2007

Detection Of Vibrio Vulnificus By Direct Colony Immunoblot, Reshani Nisansala Senevirathne

LSU Master's Theses

Vibrio vulnificus (Vv) is a natural occurring bacterium of world wide estuarine environments, which concentrate on filter feeding shellfish. Under cooked seafood contaminated with this pathogen is a leading cause of 95% of seafood-related, foodborne deaths. The development of a rapid, reliable and user-friendly method for Vv enumeration would help to reduce mortality rate. A direct colony immunoblot (DCI) method was developed and used as a rapid enumeration with high sensitivity and the specificity. This method was optimized using Vv agar plates incubated for 16 h at 35 °C. Colonies were transferred from incubated plates to polyvinylidene fluoride (PVDF) membranes …

Go to article

Spatial And Temporal Structure Of Typhoid Fever In Washington, D.C., 1895-1909: A Geographic Information Systems Exploration Of Urban Health Concerns, Sarah Elizabeth Hinman Jan 2007

Spatial And Temporal Structure Of Typhoid Fever In Washington, D.C., 1895-1909: A Geographic Information Systems Exploration Of Urban Health Concerns, Sarah Elizabeth Hinman

LSU Doctoral Dissertations

The period between 1880 and 1920 was one of the most dynamic in the history of medicine. Morbidity and mortality rates for infectious diseases dropped quickly. Concurrently, miasmatic theory gave way to germ theory. Many of these dynamic changes occurred in the urban centers of North America, which were also entering into a period of dramatic growth and change. Following the 1905 completion of infrastructure improvements intended to improve public health in Washington, D.C., typhoid fever rates unexpectedly increased. Previously, for mitigation purposes, Dr. George Kober investigated a typhoid epidemic in 1895, and as a result of the 1906 increase …

Go to article

First Prev Next Last